Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
CHEMBL1627325 215590 0 None -1 8 Human 10.3 pEC50 = 10.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)(C)C)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O 10.1021/jm900604g
2098 10466 36 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
36511 10466 36 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
3805 10466 36 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
3835 10466 36 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
CHEMBL235363 10466 36 None -1 11 Human 10.2 pEC50 = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilizationAntagonist activity at human recombinant NK1 receptor expressed in CHO cells assessed as inhibition of NPS-induced intracellular calcium mobilization
ChEMBL None None None None 10.1021/jm900604g
CHEMBL384518 219107 12 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(N)=O 10.1021/jm000093v
2098 10466 36 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
36511 10466 36 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
3805 10466 36 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
3835 10466 36 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
CHEMBL235363 10466 36 None -1 11 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 minsAgonist activity at wild type human NK1 receptor expressed in HEK293 cells assessed as increase in [3H]IP accumulation after 20 mins
ChEMBL None None None None 10.1021/jm2017072
2098 10466 36 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
36511 10466 36 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
3805 10466 36 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
3835 10466 36 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
CHEMBL235363 10466 36 None -1 11 Human 9.0 pEC50 = 9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None None 10.1021/jm000093v
2098 10466 36 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
36511 10466 36 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3805 10466 36 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3835 10466 36 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
CHEMBL235363 10466 36 None -2 11 Guinea pig 9.0 pEC50 = 9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
73356363 96279 0 None 9 2 Guinea pig 8.9 pEC50 = 8.9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL2372949 96279 0 None 9 2 Guinea pig 8.9 pEC50 = 8.9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44355648 103899 0 None -22 3 Guinea pig 6.0 pEC50 = 6.0 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 994 29 10 13 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL267712 103899 0 None -22 3 Guinea pig 6.0 pEC50 = 6.0 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 994 29 10 13 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O 10.1021/jm00100a027
44355117 28560 0 None -19 3 Guinea pig 6.0 pEC50 = 6.0 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 946 28 10 13 -2.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL131923 28560 0 None -19 3 Guinea pig 6.0 pEC50 = 6.0 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 946 28 10 13 -2.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O 10.1021/jm00100a027
44297675 107396 0 None -47 2 Guinea pig 6.9 pEC50 = 6.9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL291903 107396 0 None -47 2 Guinea pig 6.9 pEC50 = 6.9 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 711 22 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
10259515 163916 0 None 954 2 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL407511 163916 0 None 954 2 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL263185 217340 5 None 2 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm000093v
2089 9542 28 None -6 8 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
3795 9542 28 None -6 8 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
5311311 9542 28 None -6 8 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL217406 9542 28 None -6 8 Guinea pig 7.9 pEC50 = 7.9 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL415159 219954 5 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at bfSPR to produce increase in intracellular [Ca2+]Agonist activity at bfSPR to produce increase in intracellular [Ca2+]
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O 10.1021/jm000093v
44297866 108821 0 None -38 2 Guinea pig 7.8 pEC50 = 7.8 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL301841 108821 0 None -38 2 Guinea pig 7.8 pEC50 = 7.8 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL441061 220658 19 None 2 2 Guinea pig 8.7 pEC50 = 8.7 Functional
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
73348740 96281 0 None 51 2 Guinea pig 8.4 pEC50 = 8.4 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL2372953 96281 0 None 51 2 Guinea pig 8.4 pEC50 = 8.4 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44355678 30261 0 None 4 2 Guinea pig 6.5 pEC50 = 6.5 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 777 21 5 8 2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL133362 30261 0 None 4 2 Guinea pig 6.5 pEC50 = 6.5 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 777 21 5 8 2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
10350201 123939 0 None -6 2 Guinea pig 5.4 pEC50 = 5.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL339391 123939 0 None -6 2 Guinea pig 5.4 pEC50 = 5.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
10327810 123514 0 None -31 2 Guinea pig 4.4 pEC50 = 4.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL337465 123514 0 None -31 2 Guinea pig 4.4 pEC50 = 4.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
10055612 103200 0 None 31 3 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 711 23 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL262049 103200 0 None 31 3 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 711 23 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
14860666 112196 0 None -3 2 Guinea pig 7.4 pEC50 = 7.4 Functional
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL 710 21 6 8 1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)COC[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
CHEMBL311917 112196 0 None -3 2 Guinea pig 7.4 pEC50 = 7.4 Functional
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL 710 21 6 8 1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)COC[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
2098 10466 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
36511 10466 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3805 10466 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
3835 10466 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
CHEMBL235363 10466 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
Agonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at neurokinin-1 (NK-1) receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL None None None None 10.1021/jm00169a003
15931130 108758 0 None -1000 2 Guinea pig 6.4 pEC50 = 6.4 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL301477 108758 0 None -1000 2 Guinea pig 6.4 pEC50 = 6.4 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 737 21 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
5311135 28495 12 None -1148 3 Guinea pig 5.4 pEC50 = 5.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 920 29 11 13 -2.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL131872 28495 12 None -1148 3 Guinea pig 5.4 pEC50 = 5.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 920 29 11 13 -2.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
44355179 31120 0 None -33 2 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 962 30 11 13 -2.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134091 31120 0 None -33 2 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 962 30 11 13 -2.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134481 215508 0 None -1 3 Guinea pig 7.4 pEC50 = 7.4 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(N)=O 10.1021/jm00100a027
2098 10466 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
36511 10466 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
3805 10466 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
3835 10466 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL235363 10466 36 None -2 11 Guinea pig 8.3 pEC50 = 8.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
10395375 123435 0 None -2 2 Guinea pig 5.3 pEC50 = 5.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL337037 123435 0 None -2 2 Guinea pig 5.3 pEC50 = 5.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
10462850 31035 0 None -36 2 Guinea pig 6.3 pEC50 = 6.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134012 31035 0 None -36 2 Guinea pig 6.3 pEC50 = 6.3 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
15931129 201757 0 None 1 2 Guinea pig 8.2 pEC50 = 8.2 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 697 22 7 8 0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL54622 201757 0 None 1 2 Guinea pig 8.2 pEC50 = 8.2 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 697 22 7 8 0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL81919 222665 0 None -676 2 Guinea pig 6.2 pEC50 = 6.2 Functional
Effective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropineEffective dose was measured on NK1 receptors of guinea pig ileum for maximal contraction in the presence of 3*10e-7 M atropine
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1021/jm00112a018
CHEMBL335054 218259 0 None -20 3 Guinea pig 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
44297852 105783 0 None -7 2 Guinea pig 7.2 pEC50 = 7.2 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 763 20 5 8 1.9 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL280020 105783 0 None -7 2 Guinea pig 7.2 pEC50 = 7.2 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 763 20 5 8 1.9 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
2090 9543 25 None -6 9 Guinea pig 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
5311312 9543 25 None -6 9 Guinea pig 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL437797 9543 25 None -6 9 Guinea pig 7.2 pEC50 = 7.2 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL None None None None 10.1021/jm00100a027
11765601 103199 0 None -9 2 Guinea pig 6.1 pEC50 = 6.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL262048 103199 0 None -9 2 Guinea pig 6.1 pEC50 = 6.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
44355368 32413 0 None -1 3 Guinea pig 7.1 pEC50 = 7.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 737 22 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL135186 32413 0 None -1 3 Guinea pig 7.1 pEC50 = 7.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 737 22 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
10009596 122287 0 None 1 2 Guinea pig 7.1 pEC50 = 7.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 663 22 7 8 0.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
CHEMBL335248 122287 0 None 1 2 Guinea pig 7.1 pEC50 = 7.1 Functional
In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.
ChEMBL 663 22 7 8 0.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
73356365 96282 0 None - 1 Guinea pig 6.1 pEC50 = 6.1 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 752 21 8 7 1.5 CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00169a003
CHEMBL2372954 96282 0 None - 1 Guinea pig 6.1 pEC50 = 6.1 Functional
Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleAgonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscle
ChEMBL 752 21 8 7 1.5 CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00169a003
108167 9631 8 None 58 2 Guinea pig 10.7 pIC50 = 10.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 10.1016/s0960-894x(98)00260-1
2107 9631 8 None 58 2 Guinea pig 10.7 pIC50 = 10.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 10.1016/s0960-894x(98)00260-1
CHEMBL1178725 9631 8 None 58 2 Guinea pig 10.7 pIC50 = 10.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 10.1016/s0960-894x(98)00260-1
135434109 11054 0 None - 1 Rat 10.1 pIC50 = 10.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL100636 11054 0 None - 1 Rat 10.1 pIC50 = 10.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
9967131 214284 1 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 326 6 2 4 3.3 COc1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/s0960-894x(98)00012-2
CHEMBL94461 214284 1 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 326 6 2 4 3.3 COc1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/s0960-894x(98)00012-2
10363809 118907 20 None - 1 Human 10.0 pIC50 = 10.0 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 403 7 2 5 2.7 COc1ccc(N(C)S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL329007 118907 20 None - 1 Human 10.0 pIC50 = 10.0 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 403 7 2 5 2.7 COc1ccc(N(C)S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
44328454 175517 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 330 5 2 3 3.9 COc1ccc(Cl)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL437075 175517 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 330 5 2 3 3.9 COc1ccc(Cl)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10111225 214256 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 394 7 2 4 4.6 CCOc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL94328 214256 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 394 7 2 4 4.6 CCOc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10477054 11265 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL102032 11265 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
10458573 11137 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 498 6 1 4 6.3 C[C@@H](O[C@H]1CCCN(Cc2nc[nH]n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL101148 11137 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 498 6 1 4 6.3 C[C@@H](O[C@H]1CCCN(Cc2nc[nH]n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
135488049 214994 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 514 6 2 5 6.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL98524 214994 0 None - 1 Rat 9.8 pIC50 = 9.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 514 6 2 5 6.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
2102 7972 21 None 6 2 Human 9.8 pIC50 = 9.8 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1016285
5311057 7972 21 None 6 2 Human 9.8 pIC50 = 9.8 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1016285
CHEMBL441225 7972 21 None 6 2 Human 9.8 pIC50 = 9.8 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1016285
10480465 215194 0 None 1 2 Rat 9.7 pIC50 = 9.7 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL99792 215194 0 None 1 2 Rat 9.7 pIC50 = 9.7 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
10272852 114670 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 408 7 2 4 5.0 CC(C)Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL319301 114670 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 408 7 2 4 5.0 CC(C)Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
9821217 114507 21 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL319118 114507 21 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL3215877 114507 21 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
9871754 12181 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
CHEMBL107172 12181 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
2098 10466 36 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
36511 10466 36 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
3805 10466 36 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
3835 10466 36 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
CHEMBL235363 10466 36 None -1 11 Human 9.6 pIC50 = 9.6 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL None None None None 10.1016/S0960-894X(97)10097-X
44433394 153436 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
CHEMBL392368 153436 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
44433394 153436 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
CHEMBL392368 153436 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
9960689 18777 1 None - 1 Guinea pig 9.5 pIC50 = 9.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183286 18777 1 None - 1 Guinea pig 9.5 pIC50 = 9.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288600 18777 1 None - 1 Guinea pig 9.5 pIC50 = 9.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 619 9 0 2 8.2 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
9871754 12181 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
CHEMBL107172 12181 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
9945487 214530 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 332 6 2 3 3.9 FC(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL95852 214530 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 332 6 2 3 3.9 FC(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10268178 214438 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 324 6 2 3 4.1 CC(C)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL95315 214438 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 324 6 2 3 4.1 CC(C)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
2102 7972 21 None 6 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
5311057 7972 21 None 6 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL441225 7972 21 None 6 2 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
104943 62160 39 None 4 4 Guinea pig 9.3 pIC50 = 9.3 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10097-X
CHEMBL16192 62160 39 None 4 4 Guinea pig 9.3 pIC50 = 9.3 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10097-X
22879211 214922 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 339 6 2 4 3.3 COc1ccc(N(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL98125 214922 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 339 6 2 4 3.3 COc1ccc(N(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
44433393 174426 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
CHEMBL430170 174426 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at neurokinin 1 receptorAntagonist activity at neurokinin 1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.09.053
44433393 174426 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
CHEMBL430170 174426 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at neurokinin K1 receptorAntagonist activity at neurokinin K1 receptor
ChEMBL 352 5 2 3 4.6 COc1ccc(C(C)(C)C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm1013693
2098 10466 36 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
36511 10466 36 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
3805 10466 36 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
3835 10466 36 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
CHEMBL235363 10466 36 None -1 11 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL None None None None 10.1016/s0960-894x(98)00012-2
132846 104223 23 None 1 4 Rat 9.1 pIC50 = 9.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL1256740 104223 23 None 1 4 Rat 9.1 pIC50 = 9.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL27006 104223 23 None 1 4 Rat 9.1 pIC50 = 9.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
9968267 115333 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 350 5 2 3 4.2 FC(F)(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL320220 115333 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 350 5 2 3 4.2 FC(F)(F)Oc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
10089212 11278 0 None - 1 Rat 9.0 pIC50 = 9.0 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL102157 11278 0 None - 1 Rat 9.0 pIC50 = 9.0 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
10047566 172020 3 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm00008a003
CHEMBL422931 172020 3 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm00008a003
10650495 114196 0 None - 1 Guinea pig 9.0 pIC50 = 9 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N 10.1021/jm970499g
CHEMBL318085 114196 0 None - 1 Guinea pig 9.0 pIC50 = 9 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N 10.1021/jm970499g
11801327 16128 0 None - 1 Guinea pig 8.9 pIC50 = 8.9 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 578 10 2 4 5.4 COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL111295 16128 0 None - 1 Guinea pig 8.9 pIC50 = 8.9 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 578 10 2 4 5.4 COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
9871754 12181 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
CHEMBL107172 12181 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1016/j.bmc.2008.09.037
135413536 7236 85 None 3 3 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
230 7236 85 None 3 3 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
3490 7236 85 None 3 3 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
6918365 7236 85 None 3 3 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
CHEMBL1471 7236 85 None 3 3 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
DB00673 7236 85 None 3 3 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00793
9832207 18771 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183274 18771 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288123 18771 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10817013 16028 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O 10.1021/jm970499g
CHEMBL110770 16028 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O 10.1021/jm970499g
44327794 118199 2 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 366 5 3 4 3.9 Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL327357 118199 2 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsAntagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cells
ChEMBL 366 5 3 4 3.9 Oc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(98)00012-2
CHEMBL2369600 216413 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Compound was tested for delta antagonist activity against Tachykinin receptor 1Compound was tested for delta antagonist activity against Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm990461z
44286165 165174 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 646 8 0 4 8.3 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3C4CCC3CC3(C4)OCc4ccccc43)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1794935 165174 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 646 8 0 4 8.3 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3C4CCC3CC3(C4)OCc4ccccc43)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL40900 165174 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 646 8 0 4 8.3 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3C4CCC3CC3(C4)OCc4ccccc43)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL5074991 221128 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL None None None C[C@@H](O[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
10039383 92252 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm00008a003
CHEMBL22680 92252 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm00008a003
15542673 214343 0 None 1 2 Guinea pig 6.9 pIC50 = 6.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL94834 214343 0 None 1 2 Guinea pig 6.9 pIC50 = 6.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
44327909 119135 0 None 37 2 Guinea pig 7.9 pIC50 = 7.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 706 14 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL329450 119135 0 None 37 2 Guinea pig 7.9 pIC50 = 7.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 706 14 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL2304126 216259 0 None - 1 Rat 4.9 pIC50 = 4.9 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
9832306 119501 0 None -2 2 Guinea pig 5.9 pIC50 = 5.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10097-X
CHEMBL330367 119501 0 None -2 2 Guinea pig 5.9 pIC50 = 5.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10097-X
CHEMBL330462 119501 0 None -2 2 Guinea pig 5.9 pIC50 = 5.9 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10097-X
10123138 115303 0 None 1 2 Guinea pig 6.8 pIC50 = 6.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL317524 115303 0 None 1 2 Guinea pig 6.8 pIC50 = 6.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL320002 115303 0 None 1 2 Guinea pig 6.8 pIC50 = 6.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10190842 114001 0 None 63 2 Guinea pig 7.8 pIC50 = 7.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 788 16 0 11 7.1 COC(=O)c1ccccc1OCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
CHEMBL316705 114001 0 None 63 2 Guinea pig 7.8 pIC50 = 7.8 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 788 16 0 11 7.1 COC(=O)c1ccccc1OCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
44286051 18778 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 724 10 1 3 9.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(Cc4ccccc4)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183288 18778 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 724 10 1 3 9.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(Cc4ccccc4)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288840 18778 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 724 10 1 3 9.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(Cc4ccccc4)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44285793 107066 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 620 8 0 4 7.8 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)OCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1201933 107066 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 620 8 0 4 7.8 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)OCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL289091 107066 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 620 8 0 4 7.8 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)OCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44331794 10971 0 None - 1 Rat 6.8 pIC50 = 6.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 267 4 1 2 3.7 c1ccc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc1 10.1016/S0960-894X(97)10118-4
CHEMBL100178 10971 0 None - 1 Rat 6.8 pIC50 = 6.8 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 267 4 1 2 3.7 c1ccc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc1 10.1016/S0960-894X(97)10118-4
CHEMBL2369697 216429 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Compound was tested for delta antagonist activity against tachykinin NK-1.Tachykinin receptor 1Compound was tested for delta antagonist activity against tachykinin NK-1.Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm990461z
10769060 12806 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 10.1021/jm970499g
CHEMBL108040 12806 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 10.1021/jm970499g
44285794 148579 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 652 8 0 4 7.5 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL38624 148579 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 652 8 0 4 7.5 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44213067 18783 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 648 8 1 3 7.6 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183307 18783 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 648 8 1 3 7.6 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL289727 18783 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 648 8 1 3 7.6 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10626666 115972 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 10.1021/jm970499g
CHEMBL321554 115972 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 10.1021/jm970499g
10602943 114195 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 10.1021/jm970499g
CHEMBL318084 114195 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 10.1021/jm970499g
10168749 214400 0 None 3 2 Guinea pig 7.7 pIC50 = 7.7 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL95127 214400 0 None 3 2 Guinea pig 7.7 pIC50 = 7.7 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10745241 117308 0 None -1 2 Guinea pig 4.7 pIC50 = 4.7 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 549 8 3 4 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N 10.1021/jm970499g
CHEMBL325116 117308 0 None -1 2 Guinea pig 4.7 pIC50 = 4.7 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 549 8 3 4 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N 10.1021/jm970499g
CHEMBL2369696 216428 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Compound was tested for delta antagonist activity against Tachykinin receptor 1Compound was tested for delta antagonist activity against Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm990461z
10234086 118411 0 None 6 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL328511 118411 0 None 6 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10097-X
10258866 23374 6 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 5 4 6 3.1 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1CC1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
CHEMBL124066 23374 6 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 5 4 6 3.1 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1CC1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
136035319 170077 0 None - 1 Rat 7.6 pIC50 = 7.6 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL418800 170077 0 None - 1 Rat 7.6 pIC50 = 7.6 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 446 6 2 5 5.3 C[C@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
10027061 21724 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 456 4 1 3 5.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL120844 21724 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at NK1 receptorAntagonist activity at NK1 receptor
ChEMBL 456 4 1 3 5.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL2304029 216255 0 None - 1 Rat 4.6 pIC50 = 4.6 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@@H](CC(C)C)SCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10122529 116333 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
CHEMBL322194 116333 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10097-X
44349304 23750 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL125385 23750 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
10212645 20061 0 None 346 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 774 16 1 10 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL1191766 20061 0 None 346 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 774 16 1 10 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL542908 20061 0 None 346 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 774 16 1 10 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
15542881 119368 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330172 119368 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10233656 214630 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL96442 214630 0 None 3 2 Guinea pig 7.6 pIC50 = 7.6 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10283825 103468 0 None 1 2 Guinea pig 6.5 pIC50 = 6.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL264007 103468 0 None 1 2 Guinea pig 6.5 pIC50 = 6.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
153996 119445 2 None 1 6 Human 8.5 pIC50 = 8.5 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330366 119445 2 None 1 6 Human 8.5 pIC50 = 8.5 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL539021 119445 2 None 1 6 Human 8.5 pIC50 = 8.5 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10507650 170109 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 591 9 3 4 4.6 CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL419004 170109 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 591 9 3 4 4.6 CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
14986134 170612 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
CHEMBL4206396 170612 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
9918576 214116 0 None 2 3 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
CHEMBL93556 214116 0 None 2 3 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
44286200 148631 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 633 8 1 4 7.4 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL38652 148631 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 633 8 1 4 7.4 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NCCc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10147107 214399 0 None 3 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL431850 214399 0 None 3 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL95125 214399 0 None 3 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL2304032 216256 0 None - 1 Rat 4.5 pIC50 = 4.5 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)SCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10212223 214919 0 None 2 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL431458 214919 0 None 2 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL98079 214919 0 None 2 2 Guinea pig 7.5 pIC50 = 7.5 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
9832207 18771 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1183274 18771 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL288123 18771 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 8 1 3 7.1 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL5083565 221650 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL None None None C[C@@H](O[C@H]1O[C@@H]2CC[C@@H](c3ccccc3)O[C@@H]2[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
10121390 119516 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330499 119516 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
10123040 167874 0 None 7 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL411691 167874 0 None 7 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL537027 167874 0 None 7 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
15542879 119601 0 None 2 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330719 119601 0 None 2 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
44349364 123609 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL337987 123609 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 468 5 3 5 2.9 COc1ccc(N)cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
10578261 15955 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 535 8 2 4 4.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 10.1021/jm970499g
CHEMBL110301 15955 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 535 8 2 4 4.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 10.1021/jm970499g
10360490 95514 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.8 Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
CHEMBL23617 95514 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.8 Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
44286038 17982 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 9 1 3 7.9 CC[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3cccc(OC(C)C)c3)C2)CCC2(CC1)NCCc1ccccc12 10.1016/s0960-894x(98)00260-1
CHEMBL1178749 17982 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 9 1 3 7.9 CC[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3cccc(OC(C)C)c3)C2)CCC2(CC1)NCCc1ccccc12 10.1016/s0960-894x(98)00260-1
CHEMBL39595 17982 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 662 9 1 3 7.9 CC[N+]1(CCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)Cc3cccc(OC(C)C)c3)C2)CCC2(CC1)NCCc1ccccc12 10.1016/s0960-894x(98)00260-1
CHEMBL2304118 216258 0 None - 1 Rat 5.4 pIC50 = 5.4 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)O 10.1021/jm00157a009
10190413 214108 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL410270 214108 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL93519 214108 0 None 3 2 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10097-X
10417124 125258 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 678 5 4 6 3.4 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
CHEMBL341365 125258 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 678 5 4 6 3.4 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
44349370 124050 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
CHEMBL339488 124050 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@H]21 10.1016/0960-894X(95)00039-V
15542871 214634 0 None 1 2 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 726 9 0 7 8.0 O=C(c1nc2ccccc2n1Cc1ccc(F)cc1)C1CCN(CCC2(c3ccc4c(c3)OCO4)CCN(C(=O)c3ccc(Cl)cc3Cl)C2)CC1 10.1016/S0960-894X(97)10098-1
CHEMBL96466 214634 0 None 1 2 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 726 9 0 7 8.0 O=C(c1nc2ccccc2n1Cc1ccc(F)cc1)C1CCN(CCC2(c3ccc4c(c3)OCO4)CCN(C(=O)c3ccc(Cl)cc3Cl)C2)CC1 10.1016/S0960-894X(97)10098-1
10530375 12401 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 534 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 10.1021/jm970499g
CHEMBL107763 12401 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 534 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 10.1021/jm970499g
10917690 214384 1 None 3 4 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL95051 214384 1 None 3 4 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
44328187 214918 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 456 7 0 5 5.6 COc1ccc(CCN2CCC(=Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL98076 214918 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 456 7 0 5 5.6 COc1ccc(CCN2CCC(=Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10098-1
135556923 114177 0 None - 1 Rat 8.2 pIC50 = 8.2 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 378 6 2 5 4.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
CHEMBL317979 114177 0 None - 1 Rat 8.2 pIC50 = 8.2 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 378 6 2 5 4.0 C[C@@H](O[C@H]1CCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
9832306 119501 0 None -2 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10098-1
CHEMBL330367 119501 0 None -2 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10098-1
CHEMBL330462 119501 0 None -2 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 806 17 0 10 8.2 CCOc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(OC)c(OC)c3)C2)cc(OCC)c1OCC 10.1016/S0960-894X(97)10098-1
CHEMBL2304130 216261 0 None - 1 Rat 6.3 pIC50 = 6.3 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)C(=O)O 10.1021/jm00157a009
10917690 214384 1 None -999 4 Human 5.3 pIC50 = 5.3 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL95051 214384 1 None -999 4 Human 5.3 pIC50 = 5.3 Functional
Compound was evaluated for the antagonistic activity against NK1 receptorCompound was evaluated for the antagonistic activity against NK1 receptor
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10097-X
44285795 103275 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 647 8 1 4 6.9 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL262540 103275 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 647 8 1 4 6.9 CC(C)Oc1cccc(CC(=O)N2CCCC(CCN3CCC4(CC3)NC(=O)Cc3ccccc34)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
44349303 123997 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL339444 123997 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL2304129 216260 0 None - 1 Rat 4.3 pIC50 = 4.3 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10620143 106038 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
CHEMBL281828 106038 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
10327313 23649 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 692 5 4 6 3.7 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3cccc(C)c34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
CHEMBL124979 23649 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 692 5 4 6 3.7 Cc1cccc2c1C1(C34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3cccc(C)c34)C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@H]1N2 10.1016/0960-894X(95)00039-V
15831290 153384 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 535 7 1 3 6.4 CN(CC(CCN1CCC2(CC1)NCCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
CHEMBL39232 153384 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 535 7 1 3 6.4 CN(CC(CCN1CCC2(CC1)NCCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
10603544 117341 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 592 9 2 5 5.0 COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL325312 117341 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 592 9 2 5 5.0 COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
10190056 118215 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL327497 118215 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
44285857 17970 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 667 8 0 3 7.7 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL1178703 17970 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 667 8 0 3 7.7 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
CHEMBL38030 17970 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 667 8 0 3 7.7 CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]3(C)CCC4(CC3)c3ccccc3C[S+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(98)00260-1
10190638 214321 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94726 214321 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c(OC)c1OC 10.1016/S0960-894X(97)10098-1
10283825 103468 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL264007 103468 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 740 12 0 8 7.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(F)cc3F)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10283765 114864 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 12 0 8 7.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c1 10.1016/S0960-894X(97)10098-1
CHEMBL319535 114864 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 12 0 8 7.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)c1 10.1016/S0960-894X(97)10098-1
15542874 118946 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 786 12 0 8 8.7 COc1cc(C(=O)N2CCCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL329055 118946 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 786 12 0 8 8.7 COc1cc(C(=O)N2CCCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10769059 115394 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 10.1021/jm970499g
CHEMBL320581 115394 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Tachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileumTachykinin receptor 1 agonistic activity as inhibition of contractions evoked by 4 nM [Sar9,Met(O2)11]-SP in guinea pig ileum
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 10.1021/jm970499g
10123138 115303 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL317524 115303 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL320002 115303 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 748 12 0 10 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc4c(c3)OCO4)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
15542673 214343 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94834 214343 0 None 1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(C(F)(F)F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
18333379 214354 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 686 15 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(F)cc4)CCN(Cc4cc(OC)c(OC)c(OC)c4)C3=O)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL94906 214354 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 686 15 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(F)cc4)CCN(Cc4cc(OC)c(OC)c(OC)c4)C3=O)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10305069 214629 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 656 12 1 9 5.4 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL96441 214629 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 656 12 1 9 5.4 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL2304115 216257 0 None - 1 Rat 6.2 pIC50 = 6.2 Functional
Histamine releasing activity of Substance P from isolated rat peritoneal mast cellsHistamine releasing activity of Substance P from isolated rat peritoneal mast cells
ChEMBL None None None COC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1 10.1021/jm00157a009
10190056 118215 0 None -1 2 Guinea pig 6.2 pIC50 = 6.2 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
CHEMBL327497 118215 0 None -1 2 Guinea pig 6.2 pIC50 = 6.2 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 674 11 0 7 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3ccccc3)C2)cc1OC 10.1016/S0960-894X(97)10097-X
10212725 104945 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 790 15 1 11 6.6 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL273915 104945 0 None -1 2 Guinea pig 8.2 pIC50 = 8.2 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 790 15 1 11 6.6 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
15542679 115304 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 10 1 7 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL320003 115304 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 664 10 1 7 6.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
9918576 214116 0 None 2 3 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
CHEMBL93556 214116 0 None 2 3 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10098-1
10190413 214108 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL410270 214108 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL93519 214108 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 717 13 0 10 6.3 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1 10.1016/S0960-894X(97)10098-1
44328188 118303 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 728 16 0 11 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(OC)c(OC)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL327888 118303 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 728 16 0 11 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(OC)c(OC)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
15542879 119601 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330719 119601 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccncc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10121390 119516 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330499 119516 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 596 10 1 7 5.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5[nH]4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10123040 167874 0 None 7 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL411691 167874 0 None 7 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL537027 167874 0 None 7 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 730 13 1 9 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(C(=O)O)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10190770 214794 0 None 1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330430 214794 0 None 1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL97357 214794 0 None 1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10212223 214919 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL431458 214919 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL98079 214919 0 None 2 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 704 12 0 8 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10147107 214399 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL431850 214399 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL95125 214399 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 755 12 0 9 7.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
18333241 214572 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 736 14 0 9 7.2 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL96141 214572 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 736 14 0 9 7.2 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10233656 214630 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL96442 214630 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10147218 114243 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 778 15 0 10 7.5 CCOC(=O)CCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL318369 114243 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 778 15 0 10 7.5 CCOC(=O)CCCn1c(C(=O)C2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
15542881 119368 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL330172 119368 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 687 12 0 9 6.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4cccnc4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
44328321 174567 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 788 17 1 10 7.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL430471 174567 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 788 17 1 10 7.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCCOc4ccccc4C(=O)O)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10122529 116333 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL322194 116333 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 668 14 0 9 5.9 CCOCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10169609 214424 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 804 15 0 12 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccc(OC)c(OC)c5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL95243 214424 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 804 15 0 12 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccc(OC)c(OC)c5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
10234086 118411 0 None 6 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
CHEMBL328511 118411 0 None 6 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 744 13 0 10 6.7 COC(=O)c1ccc(Cn2c(C(=O)C3CCN(CCC4(c5ccccc5)CCN(C(=O)c5cc(OC)c(OC)c(OC)c5)C4)CC3)nc3ccccc32)cc1 10.1016/S0960-894X(97)10098-1
15542880 214285 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 705 12 0 9 6.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94480 214285 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 705 12 0 9 6.4 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccccn4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10168749 214400 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL95127 214400 0 None 3 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 676 12 0 9 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
10305888 214334 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 750 14 1 9 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCC(=O)O)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL94788 214334 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 750 14 1 9 7.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCCC(=O)O)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
44328320 214380 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 802 17 0 11 7.5 COC(=O)c1ccccc1OCCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
CHEMBL95029 214380 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 802 17 0 11 7.5 COC(=O)c1ccccc1OCCCCn1c(C(=O)C2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21 10.1016/S0960-894X(97)10098-1
10284042 214765 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 777 13 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCN4CCOCC4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL97240 214765 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 777 13 0 10 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCN4CCOCC4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
15542869 214388 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 720 15 0 10 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOCc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
CHEMBL95076 214388 0 None -1 2 Guinea pig 8.1 pIC50 = 8.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 720 15 0 10 6.6 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4CCOCc4ccco4)CC3)(c3ccccc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10098-1
9892984 151043 1 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 522 7 0 3 6.8 CN(CC(CCN1CCC2(CC1)OCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
CHEMBL39049 151043 1 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Neurokinin (NK1) receptor antagonistic activity was evaluated.Neurokinin (NK1) receptor antagonistic activity was evaluated.
ChEMBL 522 7 0 3 6.8 CN(CC(CCN1CCC2(CC1)OCc1ccccc12)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00260-1
11801586 12238 0 None 1 2 Guinea pig 5.1 pIC50 = 5.1 Functional
Tested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileumTested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileum
ChEMBL 591 9 3 4 5.2 CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL107502 12238 0 None 1 2 Guinea pig 5.1 pIC50 = 5.1 Functional
Tested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileumTested for Tachykinin receptor 1 agonistic activity by measuring its ability to inhibit contractions evoked by [Sar9,Met(O2)11]-SP (4 nM) in guinea pig ileum
ChEMBL 591 9 3 4 5.2 CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
14986135 170180 0 None -10 3 Human 4.1 pIC50 = 4.1 Functional
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
CHEMBL419500 170180 0 None -10 3 Human 4.1 pIC50 = 4.1 Functional
Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assayAntagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulation preincubated for 10 mins followed by substance-P addition measured after 30 mins by HTRF-FRET assay
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.ejmech.2017.06.056
CHEMBL5078626 221351 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assayAntagonist activity at NK1R (unknown origin) in presence of endogenous SP ligand preincubated for 10 mins followed by 30 min incubation with antagonist and SP by HTRF-FRET assay
ChEMBL None None None C[C@@H](O[C@H]1OC[C@H](O)[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
44331786 114594 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
CHEMBL319212 114594 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 349 4 1 2 5.6 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(97)10118-4
44331715 11506 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 281 4 1 2 4.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
CHEMBL103657 11506 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 281 4 1 2 4.3 C[C@@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)10118-4
44331792 113960 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
CHEMBL316486 113960 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonism of NK1 receptor in rat liver microsomes.Antagonism of NK1 receptor in rat liver microsomes.
ChEMBL 417 4 1 2 6.3 C[C@H](O[C@H]1CCCN[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)10118-4
44349375 121836 0 None - 1 Human 4.1 pIC50 = 4.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
CHEMBL334304 121836 0 None - 1 Human 4.1 pIC50 = 4.1 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 498 6 2 6 3.2 COc1ccc([N+](=O)[O-])cc1C[C@@]12C[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N3[C@@H]1Nc1ccccc12 10.1016/0960-894X(95)00039-V
10063954 105508 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
CHEMBL277918 105508 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonistic activity against human Tachykinin receptor 1Antagonistic activity against human Tachykinin receptor 1
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm00008a003
10190770 214794 0 None 1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330430 214794 0 None 1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL97357 214794 0 None 1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Antagonism of the guinea pig tachykinin NK1 receptorAntagonism of the guinea pig tachykinin NK1 receptor
ChEMBL 772 12 0 8 8.3 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
44349369 23671 0 None - 1 Human 4.0 pIC50 = 4.0 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@@H]21 10.1016/0960-894X(95)00039-V
CHEMBL125093 23671 0 None - 1 Human 4.0 pIC50 = 4.0 Functional
Antagonistic activity against Tachykinin receptor 1Antagonistic activity against Tachykinin receptor 1
ChEMBL 484 5 3 6 2.9 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@@]1(Cc3cc([N+](=O)[O-])ccc3O)c3ccccc3N[C@@H]21 10.1016/0960-894X(95)00039-V
44407908 147335 0 None - 0 Human 10.0 pKd = 10 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 687 9 1 7 4.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 10.1016/j.bmcl.2005.10.077
CHEMBL381155 147335 0 None - 0 Human 10.0 pKd = 10 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 687 9 1 7 4.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 10.1016/j.bmcl.2005.10.077
44408039 82277 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 569 8 2 5 4.9 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN 10.1016/j.bmcl.2005.10.077
CHEMBL204297 82277 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 569 8 2 5 4.9 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN 10.1016/j.bmcl.2005.10.077
44408088 146603 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 9 1 6 5.3 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL379898 146603 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 9 1 6 5.3 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44408089 146964 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL380449 146964 0 None - 0 Human 9.8 pKd = 9.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44408045 82381 0 None - 0 Human 9.5 pKd = 9.5 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 583 9 2 5 5.2 CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL204691 82381 0 None - 0 Human 9.5 pKd = 9.5 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 583 9 2 5 5.2 CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
104943 62160 39 None -4 4 Human 9.5 pKd = 9.5 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 62160 39 None -4 4 Human 9.5 pKd = 9.5 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
3086681 9052 17 None - 1 Human 9.4 pKd = 9.4 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
3510 9052 17 None - 1 Human 9.4 pKd = 9.4 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
CHEMBL42407 9052 17 None - 1 Human 9.4 pKd = 9.4 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
44370529 55833 0 None - 0 Guinea pig 9.3 pKd = 9.3 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 643 10 3 7 3.0 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O 10.1021/jm960213s
CHEMBL156128 55833 0 None - 0 Guinea pig 9.3 pKd = 9.3 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 643 10 3 7 3.0 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O 10.1021/jm960213s
44408040 81194 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 637 7 1 6 5.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL202627 81194 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 637 7 1 6 5.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44407998 82273 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 10 1 6 5.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL204262 82273 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 639 10 1 6 5.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44407971 147532 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 625 9 1 6 4.9 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL381822 147532 0 None - 0 Human 9.2 pKd = 9.2 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 625 9 1 6 4.9 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44370713 57806 0 None - 0 Guinea pig 9.1 pKd = 9.1 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 653 13 4 7 3.2 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O 10.1021/jm960213s
CHEMBL157858 57806 0 None - 0 Guinea pig 9.1 pKd = 9.1 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 653 13 4 7 3.2 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O 10.1021/jm960213s
44305816 169798 0 None - 0 Human 9.1 pKd = 9.1 Functional
Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 589 8 2 4 3.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21 10.1016/S0960-894X(96)00604-X
CHEMBL417572 169798 0 None - 0 Human 9.1 pKd = 9.1 Functional
Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 589 8 2 4 3.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21 10.1016/S0960-894X(96)00604-X
44408051 148005 0 None - 0 Human 9.1 pKd = 9.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 635 7 1 6 5.6 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL382871 148005 0 None - 0 Human 9.1 pKd = 9.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 635 7 1 6 5.6 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
21041073 145627 0 None - 0 Human 9.0 pKd = 9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL378156 145627 0 None - 0 Human 9.0 pKd = 9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
9829083 126917 0 None - 1 Human 9.0 pKd = 9 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351274 126917 0 None - 1 Human 9.0 pKd = 9 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
2102 7972 21 None 6 2 Human 8.9 pKd = 8.9 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(96)00604-X
5311057 7972 21 None 6 2 Human 8.9 pKd = 8.9 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(96)00604-X
CHEMBL441225 7972 21 None 6 2 Human 8.9 pKd = 8.9 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(96)00604-X
44407906 81483 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL203064 81483 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
9874480 81548 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 661 9 3 4 6.1 COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL203113 81548 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 661 9 3 4 6.1 COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44407907 82472 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL204764 82472 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44408025 82690 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL204979 82690 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44407917 103333 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 617 8 1 5 6.6 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 10.1016/j.bmcl.2005.10.077
CHEMBL262989 103333 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 617 8 1 5 6.6 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 10.1016/j.bmcl.2005.10.077
44407903 147500 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 655 9 1 6 6.0 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381778 147500 0 None - 0 Human 8.9 pKd = 8.9 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 655 9 1 6 6.0 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 10.1016/j.bmcl.2005.10.077
44407902 82199 0 None - 0 Human 8.8 pKd = 8.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 652 9 1 6 5.2 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 10.1016/j.bmcl.2005.10.077
CHEMBL204114 82199 0 None - 0 Human 8.8 pKd = 8.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 652 9 1 6 5.2 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 10.1016/j.bmcl.2005.10.077
44408046 147522 0 None - 0 Human 8.8 pKd = 8.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381814 147522 0 None - 0 Human 8.8 pKd = 8.8 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
104943 62160 39 None -4 4 Human 8.7 pKd = 8.7 Functional
Antagonist activity against Tachykinin receptor 1 in dog isolated carotid arteryAntagonist activity against Tachykinin receptor 1 in dog isolated carotid artery
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL16192 62160 39 None -4 4 Human 8.7 pKd = 8.7 Functional
Antagonist activity against Tachykinin receptor 1 in dog isolated carotid arteryAntagonist activity against Tachykinin receptor 1 in dog isolated carotid artery
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
44407972 147534 0 None - 0 Human 8.7 pKd = 8.7 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 9 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381825 147534 0 None - 0 Human 8.7 pKd = 8.7 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 653 9 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
44370530 55897 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 639 13 4 7 2.6 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm960213s
CHEMBL156186 55897 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
Antagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparationAntagonistic activity against Tachykinin receptor 1 was determined in the guinea pig ileum (GPI) longitudinal smooth muscle preparation
ChEMBL 639 13 4 7 2.6 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm960213s
44307819 109373 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL304106 109373 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307677 176043 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL441252 176043 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307678 205454 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL57993 205454 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44307757 210315 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66441 210315 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874206 210550 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 210550 0 None - 0 Guinea pig 8.0 pKd = 8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
57394644 75140 0 None - 0 Human 7.0 pKd = 7 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 721 10 4 6 4.3 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916633 75140 0 None - 0 Human 7.0 pKd = 7 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 721 10 4 6 4.3 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
10032981 113529 0 None - 0 Human 7.0 pKd = 7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 746 12 3 8 3.3 COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144347 113529 0 None - 0 Human 7.0 pKd = 7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 746 12 3 8 3.3 COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
10055415 113533 0 None -2 4 Human 7.0 pKd = 7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 113533 0 None -2 4 Human 7.0 pKd = 7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
118718516 122139 0 None - 0 Guinea pig 7.0 pKd = 7 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 1599 27 12 16 2.8 CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O 10.1021/jm00053a001
CHEMBL3349687 122139 0 None - 0 Guinea pig 7.0 pKd = 7 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 1599 27 12 16 2.8 CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O 10.1021/jm00053a001
9939040 11782 7 None - 2 Guinea pig 7.9 pKd = 7.9 Functional
In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL105060 11782 7 None - 2 Guinea pig 7.9 pKd = 7.9 Functional
In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1In vitro relative antagonist potency towards guinea pig Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
44307679 210296 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL66332 210296 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44307820 210414 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67171 210414 0 None - 0 Guinea pig 7.9 pKd = 7.9 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
57391132 75141 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 599 10 3 6 2.6 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916634 75141 0 None - 0 Human 6.9 pKd = 6.9 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 599 10 3 6 2.6 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
10395494 113531 0 None - 0 Human 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 12 3 8 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144349 113531 0 None - 0 Human 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 12 3 8 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
9832198 113532 0 None 1 4 Human 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 113532 0 None 1 4 Human 6.9 pKd = 6.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44384380 66598 0 None - 0 Guinea pig 6.9 pKd = 6.9 Functional
The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL172794 66598 0 None - 0 Guinea pig 6.9 pKd = 6.9 Functional
The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
44383617 162481 0 None - 0 Guinea pig 5.9 pKd = 5.9 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 961 22 8 9 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)c1cnc(C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL405167 162481 0 None - 0 Guinea pig 5.9 pKd = 5.9 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 961 22 8 9 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)c1cnc(C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
10395612 113524 0 None - 0 Human 4.9 pKd = 4.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 814 18 3 7 5.7 CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144339 113524 0 None - 0 Human 4.9 pKd = 4.9 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 814 18 3 7 5.7 CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
9801487 213777 0 None - 1 Guinea pig 6.9 pKd = 6.9 Functional
inhibiting substance P-induced contraction of the isolated guinea pig ileuminhibiting substance P-induced contraction of the isolated guinea pig ileum
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL91418 213777 0 None - 1 Guinea pig 6.9 pKd = 6.9 Functional
inhibiting substance P-induced contraction of the isolated guinea pig ileuminhibiting substance P-induced contraction of the isolated guinea pig ileum
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
52937467 69297 0 None - 1 Human 7.8 pKd = 7.8 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782141 69297 0 None - 1 Human 7.8 pKd = 7.8 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
44307898 208252 0 None - 0 Guinea pig 7.8 pKd = 7.8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL60504 208252 0 None - 0 Guinea pig 7.8 pKd = 7.8 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10418001 113530 0 None - 0 Human 6.8 pKd = 6.8 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 822 14 3 8 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144348 113530 0 None - 0 Human 6.8 pKd = 6.8 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 822 14 3 8 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL439284 220610 22 None - 0 Human 6.8 pKd = 6.8 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00063a015
44307758 210335 0 None - 0 Guinea pig 7.7 pKd = 7.7 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66635 210335 0 None - 0 Guinea pig 7.7 pKd = 7.7 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
57391133 75142 0 None - 0 Human 6.7 pKd = 6.7 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916635 75142 0 None - 0 Human 6.7 pKd = 6.7 Functional
Antagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK1 receptor expressed in CHO cells assessed as inhibition of SP-induced intracellular Ca2+ increase by Fura-2 assay
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
10350454 113508 0 None 2 4 Human 6.7 pKd = 6.7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 113508 0 None 2 4 Human 6.7 pKd = 6.7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10439730 113534 0 None -1 4 Human 6.7 pKd = 6.7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 113534 0 None -1 4 Human 6.7 pKd = 6.7 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44383164 172489 0 None - 0 Guinea pig 6.7 pKd = 6.7 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 916 21 9 7 5.3 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1c[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)n1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL424567 172489 0 None - 0 Guinea pig 6.7 pKd = 6.7 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 916 21 9 7 5.3 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1c[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)n1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL3349620 218225 11 None - 0 Guinea pig 5.7 pKd = 5.7 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin (mean +/-, n=4)Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin (mean +/-, n=4)
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00053a001
118718517 122140 0 None - 0 Guinea pig 6.6 pKd = 6.6 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 800 12 6 8 1.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349688 122140 0 None - 0 Guinea pig 6.6 pKd = 6.6 Functional
Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinTested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin
ChEMBL 800 12 6 8 1.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
44407901 147222 0 None - 0 Human 8.5 pKd = 8.5 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 701 10 1 6 6.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL380928 147222 0 None - 0 Human 8.5 pKd = 8.5 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 701 10 1 6 6.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
52937271 69295 0 None - 0 Human 8.4 pKd = 8.4 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782139 69295 0 None - 0 Human 8.4 pKd = 8.4 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
132837 9018 55 None 77 4 Human 8.4 pKd = 8.4 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
9461 9018 55 None 77 4 Human 8.4 pKd = 8.4 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
CHEMBL22870 9018 55 None 77 4 Human 8.4 pKd = 8.4 Functional
Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
52937273 69293 0 None - 0 Human 7.5 pKd = 7.5 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 458 3 0 2 4.7 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL1782137 69293 0 None - 0 Human 7.5 pKd = 7.5 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 458 3 0 2 4.7 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
10145229 15945 0 None - 0 Guinea pig 6.5 pKd = 6.5 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110219 15945 0 None - 0 Guinea pig 6.5 pKd = 6.5 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
10349900 113526 0 None -3 4 Human 6.5 pKd = 6.5 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 113526 0 None -3 4 Human 6.5 pKd = 6.5 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10350528 113510 0 None 1 4 Human 7.4 pKd = 7.4 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 113510 0 None 1 4 Human 7.4 pKd = 7.4 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44384379 136425 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL367312 136425 0 None - 0 Guinea pig 7.4 pKd = 7.4 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 933 21 8 8 6.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)s1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL170299 215622 0 None - 0 Guinea pig 6.4 pKd = 6.4 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
44408048 147336 0 None - 0 Human 8.3 pKd = 8.3 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 9 1 6 6.1 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381157 147336 0 None - 0 Human 8.3 pKd = 8.3 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 667 9 1 6 6.1 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
10259370 113525 0 None - 0 Human 7.3 pKd = 7.3 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 730 12 3 7 3.4 CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144340 113525 0 None - 0 Human 7.3 pKd = 7.3 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 730 12 3 7 3.4 CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
10506928 126996 0 None - 1 Human 6.3 pKd = 6.3 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL352102 126996 0 None - 1 Human 6.3 pKd = 6.3 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44383616 175342 0 None - 0 Guinea pig 6.3 pKd = 6.3 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 917 21 8 8 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)o1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
CHEMBL435717 175342 0 None - 0 Guinea pig 6.3 pKd = 6.3 Functional
The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle strips.
ChEMBL 917 21 8 8 5.6 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)c1cnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)o1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80692-7
10325464 126912 0 None - 1 Human 5.3 pKd = 5.3 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351236 126912 0 None - 1 Human 5.3 pKd = 5.3 Functional
Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
44307821 108891 0 None - 0 Guinea pig 8.2 pKd = 8.2 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL302329 108891 0 None - 0 Guinea pig 8.2 pKd = 8.2 Functional
In vitro functional NK1 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK1 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44337201 115389 0 None - 0 Guinea pig 8.2 pKd = 8.2 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320548 115389 0 None - 0 Guinea pig 8.2 pKd = 8.2 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
107686 10152 41 None -3 5 Guinea pig 7.2 pKd = 7.2 Functional
Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
3522 10152 41 None -3 5 Guinea pig 7.2 pKd = 7.2 Functional
Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
CHEMBL131171 10152 41 None -3 5 Guinea pig 7.2 pKd = 7.2 Functional
Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
52937270 69294 0 None - 0 Human 6.2 pKd = 6.2 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 501 5 2 3 3.4 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782138 69294 0 None - 0 Human 6.2 pKd = 6.2 Functional
Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescenceAntagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine luminescence
ChEMBL 501 5 2 3 3.4 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
44408033 81547 0 None - 0 Human 8.1 pKd = 8.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 540 6 1 4 5.6 CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL203111 81547 0 None - 0 Human 8.1 pKd = 8.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 540 6 1 4 5.6 CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44408047 103543 0 None - 0 Human 8.1 pKd = 8.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 597 9 1 5 5.5 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C 10.1016/j.bmcl.2005.10.077
CHEMBL264660 103543 0 None - 0 Human 8.1 pKd = 8.1 Functional
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cellsEffect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
ChEMBL 597 9 1 5 5.5 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C 10.1016/j.bmcl.2005.10.077
15887537 115823 0 None - 0 Guinea pig 7.1 pKd = 7.1 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL321270 115823 0 None - 0 Guinea pig 7.1 pKd = 7.1 Functional
Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.Inhibition of the SP-induced NK1-mediated enhancement of the EFS-induced sympathetic neurogenic contractions of gpvd, used as a measure of antagonist activity.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
21121353 108250 0 None 16 4 Human 7.1 pKd = 7.1 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 108250 0 None 16 4 Human 7.1 pKd = 7.1 Functional
Tested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonistTested for antagonist activity against NK1 receptor in rabbit vena cava by using substance P (SP) as agonist
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
57392804 74759 0 None - 0 Human 10.3 pKi = 10.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911965 74759 0 None - 0 Human 10.3 pKi = 10.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911967 74759 0 None - 0 Human 10.3 pKi = 10.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57403249 78284 0 None - 0 Human 10.2 pKi = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 625 6 1 4 6.3 Cc1cc(F)ccc1-c1cc(C2CN(C)C(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911968 78284 0 None - 0 Human 10.2 pKi = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 625 6 1 4 6.3 Cc1cc(F)ccc1-c1cc(C2CN(C)C(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1962728 78284 0 None - 0 Human 10.2 pKi = 10.2 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 625 6 1 4 6.3 Cc1cc(F)ccc1-c1cc(C2CN(C)C(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 74758 0 None - 0 Human 10.1 pKi = 10.1 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 74758 0 None - 0 Human 10.1 pKi = 10.1 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
52933155 74762 0 None - 0 Human 10.0 pKi = 10 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 641 7 3 5 5.5 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2(CO)CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911970 74762 0 None - 0 Human 10.0 pKi = 10 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 641 7 3 5 5.5 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2(CO)CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57392804 74759 0 None - 0 Human 9.8 pKi = 9.8 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911965 74759 0 None - 0 Human 9.8 pKi = 9.8 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911967 74759 0 None - 0 Human 9.8 pKi = 9.8 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 74758 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 74758 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57392804 74759 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911965 74759 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911967 74759 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.0 Cc1cc(F)ccc1-c1cc(C2CNC(=O)C2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57398076 74761 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.1 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911969 74761 0 None - 0 Human 9.6 pKi = 9.6 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.1 Cc1cc(F)ccc1-c1cc(C2CC(=O)NC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 74758 0 None - 0 Human 9.5 pKi = 9.5 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 74758 0 None - 0 Human 9.5 pKi = 9.5 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
57396275 74758 0 None - 0 Human 9.3 pKi = 9.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
CHEMBL1911964 74758 0 None - 0 Human 9.3 pKi = 9.3 Functional
Antagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assayAntagonist activity at human recombinant NK1 receptor expressed in human U20S cells assessed as effect on substance P-induced intracellular calcium level by FLIPR assay
ChEMBL 611 6 2 4 6.3 Cc1cc(F)ccc1-c1cc(C2NC(=O)CC2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2011.07.116
2096 10416 0 None 25 2 Guinea pig 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
2096 10416 0 None 25 2 Guinea pig 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
25078100 10416 0 None 25 2 Guinea pig 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
25078100 10416 0 None 25 2 Guinea pig 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
16131028 10417 0 None 112 2 Guinea pig 7.6 pA2 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
16131028 10417 0 None 112 2 Guinea pig 7.6 pA2 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
2097 10417 0 None 112 2 Guinea pig 7.6 pA2 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1693780
2097 10417 0 None 112 2 Guinea pig 7.6 pA2 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
16131028 10417 0 None -112 2 Rat 5.5 pEC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
2097 10417 0 None -112 2 Rat 5.5 pEC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
2096 10416 0 None -25 2 Rat 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
25078100 10416 0 None -25 2 Rat 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1702895
135413536 7236 85 None -3 3 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
230 7236 85 None -3 3 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
3490 7236 85 None -3 3 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
6918365 7236 85 None -3 3 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
CHEMBL1471 7236 85 None -3 3 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
DB00673 7236 85 None -3 3 Mongolian jird 8.0 pIC50 = 8 Functional
NoneNone
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
30699 224483 0 None -1 14 Human 8.3 pIC50 = 8.3 Functional
NoneNone
Drug Central 423 7 2 8 0.5 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSC1=CC=NC=C1)C2=O)C(O)=O None
10328936 8328 30 None 2 2 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
2086 8328 30 None 2 2 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
2955 8328 30 None 2 2 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
CHEMBL373569 8328 30 None 2 2 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
135413538 8460 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
4470 8460 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
7623 8460 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
CHEMBL1199324 8460 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
DB06717 8460 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
2096 10416 0 None -25 2 Rat 5.7 pIC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 6208451
25078100 10416 0 None -25 2 Rat 5.7 pIC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 6208451
2088 8958 0 None 1 2 Human 6.9 pIC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
45749 8958 0 None 1 2 Human 6.9 pIC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2101 10469 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
155817436 9569 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2092 9569 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
107686 10152 41 None -3 5 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 1281470
3522 10152 41 None -3 5 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 1281470
CHEMBL131171 10152 41 None -3 5 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 1281470
10328936 8328 30 None 2 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2086 8328 30 None 2 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2955 8328 30 None 2 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
CHEMBL373569 8328 30 None 2 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
3849 9968 0 None - 1 Rat 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9243521
135413538 8460 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
4470 8460 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
7623 8460 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
CHEMBL1199324 8460 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
DB06717 8460 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 7 3 7 4.4 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1nc(=O)n([nH]1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
108167 9631 8 None -58 2 Human 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 8702757
2107 9631 8 None -58 2 Human 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 8702757
CHEMBL1178725 9631 8 None -58 2 Human 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 619 9 0 2 8.2 CC(Oc1cccc(c1)CC(=O)N1CCC[C@](C1)(CC[N+]12CCC(CC1)(CC2)c1ccccc1)c1ccc(c(c1)Cl)Cl)C 8702757
17268 9891 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2094 9891 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
10349 9031 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 575 8 1 6 5.7 CN(Cc1n[nH]nc1CN1CCO[C@@H]([C@@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 11708932
9809077 9031 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 575 8 1 6 5.7 CN(Cc1n[nH]nc1CN1CCO[C@@H]([C@@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 11708932
CHEMBL4303434 9031 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 575 8 1 6 5.7 CN(Cc1n[nH]nc1CN1CCO[C@@H]([C@@H]1c1ccc(cc1)F)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 11708932
3850 10259 0 None - 1 Human 9.8 pIC50 = 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
3086681 9052 17 None - 1 Human 9.8 pIC50 = 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 20533894
3510 9052 17 None - 1 Human 9.8 pIC50 = 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 20533894
CHEMBL42407 9052 17 None - 1 Human 9.8 pIC50 = 9.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 20533894
2110 9743 38 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
219077 9743 38 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
3480 9743 38 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
CHEMBL346178 9743 38 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
DB04872 9743 38 None -2041 3 Human 5.6 pIC50 None 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 9042606
2100 10468 0 None - 1 Human 6.4 pIC50 None 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2091 9571 0 None -223 2 Human 6.5 pIC50 None 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2099 10467 0 None - 1 Human 7.9 pIC50 None 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2103 8424 0 None - 1 Human 7.9 pIC50 None 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1378096
6437864 8424 0 None - 1 Human 7.9 pIC50 None 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1378096
132629 9017 15 None - 1 Human 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 8702757
2104 9017 15 None - 1 Human 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 8702757
CHEMBL24999 9017 15 None - 1 Human 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 8702757
168489 9890 0 None - 1 Human 8.4 pIC50 None 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2093 9890 0 None - 1 Human 8.4 pIC50 None 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8702757
2109 10909 4 None - 1 Human 9.9 pIC50 None 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 11408556
9852253 10909 4 None - 1 Human 9.9 pIC50 None 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 11408556
CHEMBL129683 10909 4 None - 1 Human 9.9 pIC50 None 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 11408556
132837 9018 55 None -83 4 Rat 6.3 pIC50 ~ 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
9461 9018 55 None -83 4 Rat 6.3 pIC50 ~ 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
CHEMBL22870 9018 55 None -83 4 Rat 6.3 pIC50 ~ 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
392622 63086 95 None - 4 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
CHEMBL163 63086 95 None - 4 Human 5.9 pAC50 = 5.9 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 10.1038/s41467-023-40064-9
3793 209988 77 None - 1 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 704 11 0 12 5.6 CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O 10.1038/s41467-023-40064-9
45039617 209988 77 None - 1 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 704 11 0 12 5.6 CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O 10.1038/s41467-023-40064-9
CHEMBL64391 209988 77 None - 1 Human 5.8 pAC50 = 5.8 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 704 11 0 12 5.6 CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O 10.1038/s41467-023-40064-9
3883 190314 112 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 369 5 1 4 3.5 Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1 10.1038/s41467-023-40064-9
CHEMBL480 190314 112 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 369 5 1 4 3.5 Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1 10.1038/s41467-023-40064-9
43815 193699 64 None - 25 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1038/s41467-023-40064-9
CHEMBL1708 193699 64 None - 25 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1038/s41467-023-40064-9
CHEMBL490 193699 64 None - 25 Human 6.7 pAC50 = 6.7 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1038/s41467-023-40064-9
1890 9535 49 None - 16 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
4449 9535 49 None - 16 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
7247 9535 49 None - 16 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
CHEMBL623 9535 49 None - 16 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
DB01149 9535 49 None - 16 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 469 10 0 7 3.6 CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl 10.1038/s41467-023-40064-9
191 7191 98 None - 29 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
201 7191 98 None - 29 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
2170 7191 98 None - 29 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
CHEMBL1113 7191 98 None - 29 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
DB00543 7191 98 None - 29 Human 5.6 pAC50 = 5.6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1 10.1038/s41467-023-40064-9
212 10578 47 None - 25 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
2639 10578 47 None - 25 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
941651 10578 47 None - 25 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
CHEMBL1201 10578 47 None - 25 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
DB01623 10578 47 None - 25 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 443 5 0 5 3.5 CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C 10.1038/s41467-023-40064-9
2247 7293 81 None -117 42 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
249 7293 81 None -117 42 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
2603 7293 81 None -117 42 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
CHEMBL296419 7293 81 None -117 42 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
DB00637 7293 81 None -117 42 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 10.1038/s41467-023-40064-9
2585 7590 103 None - 22 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
522 7590 103 None - 22 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
551 7590 103 None - 22 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
CHEMBL723 7590 103 None - 22 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
DB01136 7590 103 None - 22 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
11434515 7049 6 None - 5 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
11519741 7049 6 None - 5 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
4484 7049 6 None - 5 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
7449 7049 6 None - 5 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
CHEMBL1194325 7049 6 None - 5 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
DB08897 7049 6 None - 5 Human 6.3 pAC50 = 6.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 484 9 1 6 4.7 O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2 10.1038/s41467-023-40064-9
213 10625 55 None - 43 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
2717 10625 55 None - 43 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
5533 10625 55 None - 43 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
CHEMBL621 10625 55 None - 43 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
DB00656 10625 55 None - 43 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2 10.1038/s41467-023-40064-9
10034073 23933 29 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 1056 13 7 18 6.2 CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL1255800 23933 29 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 1056 13 7 18 6.2 CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C 10.1038/s41467-023-40064-9
2600 10551 74 None - 13 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
2608 10551 74 None - 13 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
5405 10551 74 None - 13 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
CHEMBL17157 10551 74 None - 13 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
DB00342 10551 74 None - 13 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
644241 101961 121 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 529 6 2 7 6.4 Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 10.1038/s41467-023-40064-9
CHEMBL255863 101961 121 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 529 6 2 7 6.4 Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 10.1038/s41467-023-40064-9
5360696 8188 30 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 271 1 0 2 3.4 COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C 10.1038/s41467-023-40064-9
6953 8188 30 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 271 1 0 2 3.4 COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C 10.1038/s41467-023-40064-9
842 8188 30 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 271 1 0 2 3.4 COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C 10.1038/s41467-023-40064-9
CHEMBL52440 8188 30 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 271 1 0 2 3.4 COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C 10.1038/s41467-023-40064-9
DB00514 8188 30 None - 3 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 271 1 0 2 3.4 COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C 10.1038/s41467-023-40064-9
5328940 106992 107 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 529 9 1 8 5.2 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl 10.1038/s41467-023-40064-9
CHEMBL288441 106992 107 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 529 9 1 8 5.2 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl 10.1038/s41467-023-40064-9
3157 8252 71 None - 12 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
7170 8252 71 None - 12 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
954 8252 71 None - 12 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
CHEMBL707 8252 71 None - 12 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
DB00590 8252 71 None - 12 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2 10.1038/s41467-023-40064-9
1353 8692 93 None - 85 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
3559 8692 93 None - 85 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
86 8692 93 None - 85 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
CHEMBL54 8692 93 None - 85 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
DB00502 8692 93 None - 85 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl 10.1038/s41467-023-40064-9
242 7258 124 None - 51 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
34 7258 124 None - 51 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
60795 7258 124 None - 51 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
CHEMBL1112 7258 124 None - 51 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
DB01238 7258 124 None - 51 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL 447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl 10.1038/s41467-023-40064-9
1024 8072 71 None - 1 Human 6.0 pAC50 = 6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
162639143 8072 71 None - 1 Human 6.0 pAC50 = 6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
5284373 8072 71 None - 1 Human 6.0 pAC50 = 6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
760 8072 71 None - 1 Human 6.0 pAC50 = 6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
CHEMBL160 8072 71 None - 1 Human 6.0 pAC50 = 6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
DB00091 8072 71 None - 1 Human 6.0 pAC50 = 6 Binding
Binding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR1 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
2098 10466 36 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
36511 10466 36 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
3805 10466 36 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
3835 10466 36 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
CHEMBL235363 10466 36 None 1 6 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None None 10.1021/jm000093v
CHEMBL384518 219107 12 None - 0 Human 9.2 pEC50 = 9.2 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(N)=O 10.1021/jm000093v
CHEMBL428532 220234 6 None - 0 Guinea pig 8.8 pEC50 = 8.8 Binding
Compound was evaluated for effective dose against Muscular receptor in guinea pig ileumCompound was evaluated for effective dose against Muscular receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
44337561 103513 0 None - 0 Guinea pig 8.0 pEC50 = 8.0 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL264395 103513 0 None - 0 Guinea pig 8.0 pEC50 = 8.0 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44308430 109040 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL303222 109040 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 921 19 9 10 -0.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL2371799 216906 0 None - 0 Guinea pig 5.9 pEC50 = 5.9 Binding
Compound was evaluated for effective dose against neuronal receptor in guinea pig ileumCompound was evaluated for effective dose against neuronal receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
CHEMBL263185 217340 5 None - 0 Human 7.9 pEC50 = 7.9 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm000093v
CHEMBL415159 219954 5 None - 0 Human 7.9 pEC50 = 7.9 Binding
SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O 10.1021/jm000093v
44337560 116527 0 None - 0 Guinea pig 6.8 pEC50 = 6.8 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 950 19 9 10 0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL323028 116527 0 None - 0 Guinea pig 6.8 pEC50 = 6.8 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 950 19 9 10 0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44337787 15939 0 None - 0 Guinea pig 6.8 pEC50 = 6.8 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL110177 15939 0 None - 0 Guinea pig 6.8 pEC50 = 6.8 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44308431 171301 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL421485 171301 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 907 19 9 10 -0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL2371799 216906 0 None - 0 Guinea pig 8.7 pEC50 = 8.7 Binding
Compound was evaluated for effective dose against muscular receptor in guinea pig ileumCompound was evaluated for effective dose against muscular receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
132629 9017 15 None - 0 Human 7.6 pEC50 = 7.6 Binding
Displacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/np058114h
2104 9017 15 None - 0 Human 7.6 pEC50 = 7.6 Binding
Displacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/np058114h
CHEMBL24999 9017 15 None - 0 Human 7.6 pEC50 = 7.6 Binding
Displacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SR140333 from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/np058114h
CHEMBL422779 220092 0 None - 0 Guinea pig 8.5 pEC50 = 8.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(N)=O 10.1021/jm960154i
CHEMBL106184 215249 0 None - 0 Guinea pig 6.5 pEC50 = 6.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN(CCCN)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(N)=O 10.1021/jm960154i
108147 10355 36 None - 3 Guinea pig 4.5 pEC50 = 4.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None None 10.1021/jm960154i
2127 10355 36 None - 3 Guinea pig 4.5 pEC50 = 4.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None None 10.1021/jm960154i
CHEMBL106124 10355 36 None - 3 Guinea pig 4.5 pEC50 = 4.5 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL None None None None 10.1021/jm960154i
CHEMBL428532 220234 6 None - 0 Guinea pig 8.4 pEC50 = 8.4 Binding
Compound was evaluated for effective dose against Neuronal receptor in guinea pig ileumCompound was evaluated for effective dose against Neuronal receptor in guinea pig ileum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(N)=O 10.1021/jm00157a029
10843656 103597 0 None - 0 Guinea pig 6.4 pEC50 = 6.4 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 1009 34 10 11 -0.1 CNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCNC(C)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm960154i
CHEMBL265115 103597 0 None - 0 Guinea pig 6.4 pEC50 = 6.4 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 1009 34 10 11 -0.1 CNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCNC(C)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm960154i
44337775 170186 0 None - 0 Guinea pig 5.4 pEC50 = 5.4 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 893 19 9 10 -1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL419558 170186 0 None - 0 Guinea pig 5.4 pEC50 = 5.4 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 893 19 9 10 -1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44337797 115791 0 None - 0 Guinea pig 8.3 pEC50 = 8.3 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL321228 115791 0 None - 0 Guinea pig 8.3 pEC50 = 8.3 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
44308550 108895 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
CHEMBL302349 108895 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Tested for the biological activity and selectivity against NK-1 receptorTested for the biological activity and selectivity against NK-1 receptor
ChEMBL 936 19 9 10 0.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm00040a005
162673403 189828 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 3435 125 39 39 2.9 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
CHEMBL4794099 189828 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 3435 125 39 39 2.9 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
44337530 174676 0 None - 0 Guinea pig 7.2 pEC50 = 7.2 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 964 19 9 10 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
CHEMBL431243 174676 0 None - 0 Guinea pig 7.2 pEC50 = 7.2 Binding
Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)Effective concentration to activate Tachykinin receptor 1 in guinea pig ileum(GPI)
ChEMBL 964 19 9 10 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CN1CCCCCCNC(=O)CCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O)C(N)=O 10.1021/jm960154i
162651127 187060 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 2299 83 25 24 7.8 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
CHEMBL4750714 187060 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Binding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assayBinding affinity to NK1R (unknown origin) expressed in HEK293 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
ChEMBL 2299 83 25 24 7.8 CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC 10.1016/j.bmcl.2020.127353
11238415 106030 0 None - 0 Human 11.0 pIC50 = 11 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 566 5 1 2 7.8 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CBr)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL281797 106030 0 None - 0 Human 11.0 pIC50 = 11 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 566 5 1 2 7.8 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CBr)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
11352855 103891 0 None - 0 Human 11.0 pIC50 = 11.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 517 6 2 3 6.6 CNCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL26761 103891 0 None - 0 Human 11.0 pIC50 = 11.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 517 6 2 3 6.6 CNCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
9821217 114507 21 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL319118 114507 21 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL3215877 114507 21 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
49863731 22102 0 None - 3 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214024 22102 0 None - 3 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
25129133 195666 0 None - 4 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL507340 195666 0 None - 4 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
25129133 195666 0 None - 4 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL507340 195666 0 None - 4 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
25129133 195666 0 None - 4 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL507340 195666 0 None - 4 Human 10.9 pIC50 = 10.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
46884430 15092 0 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1092755 15092 0 None - 0 Human 10.9 pIC50 = 10.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
11852872 75402 0 None - 0 Human 10.8 pIC50 = 10.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917864 75402 0 None - 0 Human 10.8 pIC50 = 10.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
25027805 77797 0 None - 0 Human 10.8 pIC50 = 10.8 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951813 77797 0 None - 0 Human 10.8 pIC50 = 10.8 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
44178113 68038 0 None - 3 Human 10.7 pIC50 = 10.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766208 68038 0 None - 3 Human 10.7 pIC50 = 10.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
57391771 77795 0 None - 0 Human 10.7 pIC50 = 10.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951810 77795 0 None - 0 Human 10.7 pIC50 = 10.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
57395695 78397 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 559 10 2 8 3.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917866 78397 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 559 10 2 8 3.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963416 78397 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 559 10 2 8 3.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
87318292 133230 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 616 4 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651897 133230 0 None - 0 Human 10.6 pIC50 = 10.6 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 616 4 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
67232184 133224 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 548 4 0 3 4.9 CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3651891 133224 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 548 4 0 3 4.9 CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
73265457 133229 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 653 4 0 4 4.5 CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651896 133229 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 653 4 0 4 4.5 CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
11248796 168428 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 0 2 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL413027 168428 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 0 2 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 10.1021/jm034219a
122182823 128839 0 None - 0 Mongolian jird 10.5 pIC50 = 10.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 433 6 1 7 3.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596448 128839 0 None - 0 Mongolian jird 10.5 pIC50 = 10.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 433 6 1 7 3.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
44433804 153573 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392466 153573 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
73265450 133220 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 680 4 0 3 7.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3651887 133220 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 680 4 0 3 7.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
73265453 133225 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 617 4 0 4 5.0 CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651892 133225 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 617 4 0 4 5.0 CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
57402264 77735 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951626 77735 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C)C2)CC1 10.1016/j.bmc.2011.11.048
57403992 77742 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 519 4 1 2 5.3 Cc1cc(F)ccc1[C@H]1CN(C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951633 77742 0 None - 0 Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 519 4 1 2 5.3 Cc1cc(F)ccc1[C@H]1CN(C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
73265456 133228 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 590 4 1 3 5.7 CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651895 133228 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 590 4 1 3 5.7 CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
9828716 78408 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 7 2 7 3.4 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917853 78408 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 7 2 7 3.4 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963487 78408 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 7 2 7 3.4 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
127944 127703 3 None - 1 Human 10.4 pIC50 = 10.4 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL356062 127703 3 None - 1 Human 10.4 pIC50 = 10.4 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL555572 127703 3 None - 1 Human 10.4 pIC50 = 10.4 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
46881682 14869 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 14869 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46883879 14542 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089271 14542 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
57398784 77740 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 575 6 1 3 4.9 CC(=O)NCC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951631 77740 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 575 6 1 3 4.9 CC(=O)NCC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
57400919 78394 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 529 8 2 7 3.9 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC2CC2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917856 78394 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 529 8 2 7 3.9 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC2CC2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963413 78394 0 None - 0 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 529 8 2 7 3.9 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC2CC2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
57397000 77796 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 563 4 2 4 4.3 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(=O)NO)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951811 77796 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 563 4 2 4 4.3 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(=O)NO)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
11621512 77739 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 629 5 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951630 77739 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 629 5 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmc.2011.11.048
57397022 77741 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 533 4 1 2 5.6 CNC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951632 77741 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 533 4 1 2 5.6 CNC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
73265454 133226 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 646 5 1 4 6.3 COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3651893 133226 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 646 5 1 4 6.3 COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
57400917 78422 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 474 6 1 7 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917852 78422 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 474 6 1 7 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963577 78422 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 474 6 1 7 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
135539114 215081 3 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9506534
CHEMBL99055 215081 3 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9506534
135539114 215081 3 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/acs.jmedchem.1c00790
CHEMBL99055 215081 3 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/acs.jmedchem.1c00790
122182821 128837 0 None - 0 Mongolian jird 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 365 6 1 7 2.7 COc1ccc(-n2cnnn2)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596446 128837 0 None - 0 Mongolian jird 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 365 6 1 7 2.7 COc1ccc(-n2cnnn2)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
122182822 128838 0 None - 0 Mongolian jird 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 379 6 1 7 3.0 COc1ccc(-n2nnnc2C)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596447 128838 0 None - 0 Mongolian jird 10.3 pIC50 = 10.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 379 6 1 7 3.0 COc1ccc(-n2nnnc2C)cc1CO[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2015.04.098
44433798 152464 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391615 152464 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
44433797 152914 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391964 152914 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
24752718 13315 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 13315 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
135539114 215081 3 None - 0 Human 10.3 pIC50 = 10.3 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm0311487
CHEMBL99055 215081 3 None - 0 Human 10.3 pIC50 = 10.3 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm0311487
57398783 77738 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 615 5 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951629 77738 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 615 5 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
57391771 77795 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951810 77795 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 547 4 1 3 4.2 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
57395688 75400 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 490 6 1 8 3.4 COC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917851 75400 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 490 6 1 8 3.4 COC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
57390405 78396 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 9 2 8 2.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917865 78396 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 9 2 8 2.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963415 78396 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 9 2 8 2.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CCNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57397483 78395 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 7 2 7 3.5 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC2CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917859 78395 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 7 2 7 3.5 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC2CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963414 78395 0 None - 0 Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 7 2 7 3.5 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC2CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57400921 78383 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 2 7 3.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NCC(F)(F)F)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917860 78383 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 2 7 3.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NCC(F)(F)F)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963300 78383 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 2 7 3.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NCC(F)(F)F)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57395693 78384 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CN(C(C)=O)C2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917862 78384 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CN(C(C)=O)C2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963301 78384 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 557 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CN(C(C)=O)C2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44456802 104226 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 476 4 1 2 5.5 C[C@@H](O[C@H]1CN2C(=O)NC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL270090 104226 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 476 4 1 2 5.5 C[C@@H](O[C@H]1CN2C(=O)NC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
16663280 104737 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL272649 104737 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
23653789 10359 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
9280 10359 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
CHEMBL447955 10359 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
DB12973 10359 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
46881727 12366 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077241 12366 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881779 15222 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 15222 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752568 15684 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752568 15684 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1097693 15684 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 15684 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52949827 24114 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257357 24114 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
25028925 98140 4 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
CHEMBL2402572 98140 4 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
16663280 104737 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
16663280 104737 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL272649 104737 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL272649 104737 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
23653789 10359 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
9280 10359 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
CHEMBL447955 10359 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
DB12973 10359 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
44444666 161163 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 506 5 1 2 6.5 CC(C)NC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL398720 161163 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 506 5 1 2 6.5 CC(C)NC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
127944 127703 3 None - 1 Human 10.2 pIC50 = 10.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
CHEMBL356062 127703 3 None - 1 Human 10.2 pIC50 = 10.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
CHEMBL555572 127703 3 None - 1 Human 10.2 pIC50 = 10.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
46947062 24232 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 24232 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
57391807 77736 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 625 6 0 3 6.1 CCc1ccccc1[C@H]1CN(C(=O)C2CCN(C(C)=O)CC2)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951627 77736 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 625 6 0 3 6.1 CCc1ccccc1[C@H]1CN(C(=O)C2CCN(C(C)=O)CC2)CC[C@@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
24889113 14720 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 14720 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 14720 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52943848 24192 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257588 24192 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
135406581 38701 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1016/j.bmcl.2018.09.016
CHEMBL140745 38701 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1016/j.bmcl.2018.09.016
73265455 133227 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 660 5 1 4 5.4 CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651894 133227 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 660 5 1 4 5.4 CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
2098 10466 36 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
36511 10466 36 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3805 10466 36 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3835 10466 36 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL235363 10466 36 None -2 6 Guinea pig 10.2 pIC50 = 10.2 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
135406581 38701 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm980299k
CHEMBL140745 38701 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm980299k
44433800 153567 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392463 153567 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 10.1016/j.bmcl.2007.08.028
44433803 153572 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392465 153572 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 10.1016/j.bmcl.2007.08.028
24752718 13315 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 13315 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881820 14333 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1087695 14333 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881729 14711 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090421 14711 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881779 15222 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 15222 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44444634 100876 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 463 4 0 2 6.0 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL249145 100876 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 463 4 0 2 6.0 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
24180495 161461 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 483 5 0 3 6.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL399668 161461 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 483 5 0 3 6.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444643 161680 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 574 5 0 3 6.2 CC(=O)N1CCC(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
CHEMBL400848 161680 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 574 5 0 3 6.2 CC(=O)N1CCC(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
135406581 38701 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm800219f
CHEMBL140745 38701 0 None - 0 Human 10.2 pIC50 = 10.2 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 520 6 2 5 4.4 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccc(F)cc2)[nH]1 10.1021/jm800219f
73265452 133223 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 609 4 0 4 5.8 CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651890 133223 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 609 4 0 4 5.8 CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
11852872 75402 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917864 75402 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57402266 77743 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 549 5 1 3 5.5 CONC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951634 77743 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 549 5 1 3 5.5 CONC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
73265451 133222 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 666 4 0 3 6.8 CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651889 133222 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 666 4 0 3 6.8 CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
11409185 106199 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL282853 106199 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
57402690 75399 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 510 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917850 75399 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 510 7 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
9917079 67939 39 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
CHEMBL1765508 67939 39 None - 0 Human 10.1 pIC50 = 10.1 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
5752 10777 24 None - 1 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
6918331 10777 24 None - 1 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
CHEMBL522302 10777 24 None - 1 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
DB12436 10777 24 None - 1 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm980299k
71456209 85432 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 457 4 1 7 4.0 COc1ccc(-n2nnnc2C(F)(F)F)cc1C1=CC2(CCCN[C@H]2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
CHEMBL2112366 85432 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 457 4 1 7 4.0 COc1ccc(-n2nnnc2C(F)(F)F)cc1C1=CC2(CCCN[C@H]2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
46881729 14711 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090421 14711 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750734 14785 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 14785 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750888 15223 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093751 15223 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752434 15905 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 15905 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
52941351 24150 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257466 24150 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
57395691 78423 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 7 2 7 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917858 78423 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 7 2 7 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963578 78423 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 7 2 7 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)NC(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57400923 78398 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 8 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CN(C)C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917867 78398 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 8 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CN(C)C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963417 78398 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 545 8 1 8 2.6 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)CN(C)C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
10407571 174736 10 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL431690 174736 10 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
57397481 78429 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 8 2 7 3.8 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OCC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917855 78429 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 8 2 7 3.8 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OCC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963613 78429 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 517 8 2 7 3.8 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OCC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
135413536 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
230 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
3490 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
6918365 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
CHEMBL1471 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
DB00673 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmc.2013.09.001
11983278 172879 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmc.2013.09.001
CHEMBL425956 172879 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmc.2013.09.001
135413536 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2018.09.016
230 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2018.09.016
3490 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2018.09.016
6918365 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2018.09.016
CHEMBL1471 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2018.09.016
DB00673 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayAntagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assay
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2018.09.016
11983278 172879 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.02.080
CHEMBL425956 172879 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1NC(=O)CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.02.080
135413536 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00790
230 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00790
3490 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00790
6918365 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00790
CHEMBL1471 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00790
DB00673 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/acs.jmedchem.1c00790
135449286 199968 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/acs.jmedchem.1c00790
CHEMBL52330 199968 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/acs.jmedchem.1c00790
135449286 199968 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm950654w
CHEMBL52330 199968 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm950654w
135413536 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
230 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
3490 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
6918365 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
CHEMBL1471 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
DB00673 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm980299k
135485796 42024 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 6 5.2 C[C@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL143587 42024 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 6 5.2 C[C@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
135449286 199968 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm980299k
CHEMBL52330 199968 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm980299k
44407331 147991 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 557 10 3 6 3.9 CS(=O)(=O)NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL382848 147991 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 557 10 3 6 3.9 CS(=O)(=O)NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
135413536 7236 85 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
230 7236 85 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
3490 7236 85 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
6918365 7236 85 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
CHEMBL1471 7236 85 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
DB00673 7236 85 None - 2 Mongolian jird 10.1 pIC50 = 10.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2015.04.098
135413536 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
230 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
3490 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
6918365 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
CHEMBL1471 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
DB00673 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2007.08.028
44433799 95443 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 5.8 Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
CHEMBL235882 95443 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 5.8 Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
135413536 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
135413536 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
230 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
230 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
3490 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
3490 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
6918365 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
6918365 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
CHEMBL1471 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
CHEMBL1471 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
DB00673 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.035
DB00673 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2006.06.044
135449286 199968 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1016/j.bmcl.2006.06.035
CHEMBL52330 199968 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1016/j.bmcl.2006.06.035
24888943 14719 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090438 14719 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24750734 14785 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750734 14785 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1090742 14785 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 14785 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46881682 14869 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 14869 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
52947645 24015 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 24015 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52948590 24079 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257235 24079 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24993313 193810 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 532 4 1 2 6.8 CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL490869 193810 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 532 4 1 2 6.8 CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
44444631 100875 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 445 4 0 2 5.8 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL249144 100875 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 445 4 0 2 5.8 CC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmcl.2007.06.085
44444637 101276 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 477 5 0 2 6.3 CCC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL251577 101276 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 477 5 0 2 6.3 CCC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
44444685 161551 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
CHEMBL400148 161551 0 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
135413536 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
230 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
3490 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
6918365 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
CHEMBL1471 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
DB00673 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm0109558
135413536 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
230 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
3490 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
6918365 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
CHEMBL1471 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
DB00673 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm800219f
135547943 41201 26 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800219f
CHEMBL142819 41201 26 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800219f
135449286 199968 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm800219f
CHEMBL52330 199968 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Inhibition of NK1 receptorInhibition of NK1 receptor
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm800219f
135413536 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
230 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
3490 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
6918365 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
CHEMBL1471 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
DB00673 7236 85 None 50 2 Human 10.1 pIC50 = 10.1 Binding
compounds were evaluated for inhibitory activity against human Tachykinin receptor 1compounds were evaluated for inhibitory activity against human Tachykinin receptor 1
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm990617v
42611207 131564 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 651 4 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642163 131564 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 651 4 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
57399171 75401 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 6 2 7 3.3 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)cc3c2OCC3)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917857 75401 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 515 6 2 7 3.3 CCNC(=O)N1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)cc3c2OCC3)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
57398782 77730 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 597 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951621 77730 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 597 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
135413536 7236 85 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
230 7236 85 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
3490 7236 85 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
6918365 7236 85 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
CHEMBL1471 7236 85 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
DB00673 7236 85 None 50 2 Human 10.0 pIC50 = 10 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/s0960-894x(02)00563-2
135539114 215081 3 None - 0 Human 10.0 pIC50 = 10 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9700171
CHEMBL99055 215081 3 None - 0 Human 10.0 pIC50 = 10 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 500 6 2 4 5.1 O=c1[nH]nc(CN2CCC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm9700171
CHEMBL5290533 201279 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 479 4 1 8 3.4 COc1cccc(-n2nnnc2C(F)(F)F)c1[C@H]1CO[C@@]2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1021/acs.jmedchem.1c00790
135419433 38570 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 466 6 2 6 4.3 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(F)cc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL140626 38570 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 466 6 2 6 4.3 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cc(F)cc(C(F)(F)F)c1 10.1021/jm980299k
44407427 147958 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 432 7 2 4 5.0 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 10.1016/j.bmcl.2005.11.026
CHEMBL382803 147958 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 432 7 2 4 5.0 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 10.1016/j.bmcl.2005.11.026
44318589 170122 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 493 4 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL419119 170122 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 493 4 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
136094861 212588 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 590 6 2 11 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL83250 212588 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 590 6 2 11 3.2 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
136094863 113912 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 556 6 2 10 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3n[nH]c(O)n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL316141 113912 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 556 6 2 10 3.8 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3n[nH]c(O)n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
57393955 78372 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 585 7 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917863 78372 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 585 7 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963216 78372 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 585 7 1 8 3.4 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)C2CCN(C(C)=O)CC2)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
46830287 14762 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090648 14762 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24993314 177818 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
CHEMBL445686 177818 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
44444664 101253 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 5 1 2 6.1 CCNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL251387 101253 0 None - 0 Human 10.0 pIC50 = 10 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 5 1 2 6.1 CCNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
73265449 131190 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 630 4 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3639507 131190 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 630 4 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
10051762 89004 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 0 4 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21709 89004 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 0 4 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44407513 81072 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 462 8 3 5 4.2 OCC1CC2(c3ccccc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL202417 81072 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 462 8 3 5 4.2 OCC1CC2(c3ccccc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
10004377 118185 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 459 4 1 7 4.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCNC2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL327250 118185 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 459 4 1 7 4.1 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCNC2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
44325058 119229 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 539 6 1 8 4.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3c[nH]cn3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL329828 119229 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 539 6 1 8 4.7 COc1ccc(-n2nnnc2C(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3c[nH]cn3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL1651026 215605 24 None - 1 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from NK1 receptor in human U373MG cellsDisplacement of [125I]BH-SP from NK1 receptor in human U373MG cells
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2016.03.006
CHEMBL1651026 215605 24 None - 1 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from NK1 receptor in human U373MG cells measured after 30 mins by scintillation counting methodDisplacement of [125I]BH-SP from NK1 receptor in human U373MG cells measured after 30 mins by scintillation counting method
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2016.11.014
57398785 77744 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.5 CNC(=O)C(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951635 77744 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.5 CNC(=O)C(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1016/j.bmc.2011.11.048
24889113 14720 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 14720 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 14720 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46884518 14750 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 554 5 0 4 6.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090547 14750 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 554 5 0 4 6.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46884467 14763 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090649 14763 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24750734 14785 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 14785 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46884519 14865 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 7.4 Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 10.1016/j.bmcl.2010.01.120
CHEMBL1091342 14865 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 582 5 0 4 7.4 Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 10.1016/j.bmcl.2010.01.120
52943994 24604 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258967 24604 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24993955 191084 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 517 4 0 2 7.0 CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL484134 191084 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 517 4 0 2 7.0 CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
44444681 101148 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 501 5 0 3 6.7 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL250798 101148 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 501 5 0 3 6.7 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444688 161783 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(=O)C=C1N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL401415 161783 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(=O)C=C1N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
44444658 173843 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 478 4 1 2 5.7 CNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL428933 173843 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 478 4 1 2 5.7 CNC(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
45271306 202451 0 None 14 4 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL556537 202451 0 None 14 4 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
2098 10466 36 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
36511 10466 36 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
3805 10466 36 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
3835 10466 36 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
CHEMBL235363 10466 36 None 1 6 Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL None None None None 10.1021/jm034219a
2098 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
36511 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
3805 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
3835 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
CHEMBL235363 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL None None None None 10.1021/jm00109a034
2098 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
36511 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3805 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3835 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL235363 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
44274207 85348 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 1 4 5.7 Cc1ccc(-c2c(CCC(=O)N3CCC(O)(Cc4ccccc4)CC3)c3cc(Cl)ccc3n2C)cn1 10.1016/s0960-894x(01)00183-4
CHEMBL21122 85348 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 501 6 1 4 5.7 Cc1ccc(-c2c(CCC(=O)N3CCC(O)(Cc4ccccc4)CC3)c3cc(Cl)ccc3n2C)cn1 10.1016/s0960-894x(01)00183-4
10053419 89395 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 555 6 1 4 6.4 Cn1c(-c2ccc(C(F)(F)F)cn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL21792 89395 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 555 6 1 4 6.4 Cn1c(-c2ccc(C(F)(F)F)cn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
44412226 175616 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCC(=O)N(C)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL437878 175616 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCC(=O)N(C)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44433789 152912 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391963 152912 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
44444646 100796 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 546 5 0 3 5.6 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2CCC(=O)N2C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL248748 100796 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 546 5 0 3 5.6 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2CCC(=O)N2C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444693 101272 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 5 0 3 5.8 C[C@@H](O[C@@H]1CN(C2=CC(=O)N(C)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL251557 101272 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 5 0 3 5.8 C[C@@H](O[C@@H]1CN(C2=CC(=O)N(C)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444650 161681 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 5 0 4 6.3 Cc1cnc(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)cn1 10.1016/j.bmcl.2007.06.085
CHEMBL400849 161681 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 5 0 4 6.3 Cc1cnc(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)cn1 10.1016/j.bmcl.2007.06.085
2098 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
36511 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
3805 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
3835 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
CHEMBL235363 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL None None None None 10.1021/jm00085a015
2098 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
36511 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
3805 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
3835 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
CHEMBL235363 10466 36 None -1 6 Rat 9.9 pIC50 = 9.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL None None None None 10.1021/jm00080a025
CHEMBL389652 219209 0 None 2 4 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
44334114 11318 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 562 7 0 4 5.9 CN(C(=O)CN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1)c1ccccc1 10.1016/s0960-894x(01)00616-3
CHEMBL102382 11318 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 562 7 0 4 5.9 CN(C(=O)CN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1)c1ccccc1 10.1016/s0960-894x(01)00616-3
44295002 162741 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 486 6 0 6 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN(Cn3cncn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL406136 162741 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 486 6 0 6 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN(Cn3cncn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44407325 80139 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 406 6 2 4 4.5 COc1ccc(OC(F)(F)F)cc1CNC1CCC2CCC1(c1ccccc1)N2 10.1016/j.bmcl.2005.11.026
CHEMBL201362 80139 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 406 6 2 4 4.5 COc1ccc(OC(F)(F)F)cc1CNC1CCC2CCC1(c1ccccc1)N2 10.1016/j.bmcl.2005.11.026
57390403 78430 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 6 1 7 3.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)N(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917861 78430 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 6 1 7 3.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)N(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963614 78430 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 503 6 1 7 3.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCN(C(=O)N(C)C)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
46881728 12367 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077242 12367 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46881821 12372 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077281 12372 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
46884516 14598 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 567 5 0 4 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089533 14598 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 567 5 0 4 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
42639650 194974 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL499004 194974 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 569 5 0 3 8.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44444684 101059 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 7.0 CC1=C(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CCC1=O 10.1016/j.bmcl.2007.06.085
CHEMBL250390 101059 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 7.0 CC1=C(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CCC1=O 10.1016/j.bmcl.2007.06.085
44444695 101312 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC(C)(C)C2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL251768 101312 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC(C)(C)C2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44274251 89937 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 535 6 0 4 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21831 89937 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 535 6 0 4 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
10053174 106284 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 545 6 0 4 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL283318 106284 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 545 6 0 4 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44412207 147110 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCC(=O)NC[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL380680 147110 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCC(=O)NC[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
9821217 114507 21 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
CHEMBL319118 114507 21 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
CHEMBL3215877 114507 21 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
9821217 114507 21 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2005.11.026
CHEMBL319118 114507 21 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2005.11.026
CHEMBL3215877 114507 21 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2005.11.026
57403991 77734 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3cccc(C)c3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951625 77734 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3cccc(C)c3)C2)CC1 10.1016/j.bmc.2011.11.048
44456522 165663 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL409520 165663 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
22885694 148225 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL384177 148225 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24888772 14788 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090752 14788 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24752434 15905 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 15905 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
52947646 24017 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256588 24017 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52942803 24018 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256589 24018 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
44444669 161194 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 520 4 1 2 6.9 C[C@@H](O[C@@H]1CN(C(=O)NC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL398919 161194 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 520 4 1 2 6.9 C[C@@H](O[C@@H]1CN(C(=O)NC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
10186401 105703 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)cnc21 10.1016/s0960-894x(01)00182-2
CHEMBL279442 105703 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)cnc21 10.1016/s0960-894x(01)00182-2
24889114 14523 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 5 6.5 Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1089081 14523 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 5 6.5 Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
46884515 14597 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 553 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089532 14597 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 553 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46884472 14767 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090653 14767 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24993312 186132 11 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 475 4 1 2 6.7 C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL473680 186132 11 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 475 4 1 2 6.7 C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44444638 162437 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 491 5 0 2 6.6 CC(C)C(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
CHEMBL404855 162437 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 491 5 0 2 6.6 CC(C)C(=O)N1C[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccc(F)cc2)C1 10.1016/j.bmcl.2007.06.085
3086681 9052 17 None 89125 3 Human 9.8 pIC50 = 9.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
3510 9052 17 None 89125 3 Human 9.8 pIC50 = 9.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
CHEMBL42407 9052 17 None 89125 3 Human 9.8 pIC50 = 9.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
44333730 114449 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 561 7 0 3 7.5 CCC(=O)N(c1ccccc1)C1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL319046 114449 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 561 7 0 3 7.5 CCC(=O)N(c1ccccc1)C1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
10098209 105865 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL280662 105865 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00182-2
57400915 78393 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 422 6 1 4 4.1 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917844 78393 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 422 6 1 4 4.1 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963412 78393 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 422 6 1 4 4.1 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(C(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44416078 146916 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 544 8 1 4 6.9 CCN(Cc1nc[nH]n1)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL380210 146916 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 544 8 1 4 6.9 CCN(Cc1nc[nH]n1)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
16006943 148222 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 530 7 1 4 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2nc[nH]n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL384171 148222 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 530 7 1 4 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2nc[nH]n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46884473 14561 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.6 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089397 14561 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.6 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46883823 15204 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093596 15204 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52948931 24021 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256592 24021 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
44444660 161425 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 0 3 5.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCOCC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL399466 161425 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 0 3 5.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCOCC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444685 161551 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
CHEMBL400148 161551 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 515 5 0 3 6.9 CC1CC(N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)=CC1=O 10.1016/j.bmcl.2007.06.085
44444692 162253 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 503 5 0 4 5.9 C[C@@H](O[C@@H]1CN(C2=CC(=O)OC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL404001 162253 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 503 5 0 4 5.9 C[C@@H](O[C@@H]1CN(C2=CC(=O)OC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44593632 185548 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 420 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)OC2 10.1016/j.bmc.2008.06.047
CHEMBL468830 185548 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 420 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)OC2 10.1016/j.bmc.2008.06.047
44177570 68034 0 None 15 4 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766204 68034 0 None 15 4 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
10460917 170528 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL420543 170528 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
2102 7972 21 None -2 2 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9700171
5311057 7972 21 None -2 2 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9700171
CHEMBL441225 7972 21 None -2 2 Human 9.8 pIC50 = 9.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9700171
73352606 99748 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 323 5 0 3 4.0 COc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL2441368 99748 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 323 5 0 3 4.0 COc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/j.bmc.2013.09.001
10460917 170528 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL420543 170528 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
57402689 75397 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 2 4 4.3 CCNC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917845 75397 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 2 4 4.3 CCNC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
23146876 77732 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 595 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CCC(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=C(c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951623 77732 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 595 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CCC(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=C(c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
44433802 153569 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392464 153569 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
44433804 153573 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392466 153573 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
22885615 86955 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 550 10 1 4 5.7 COCCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL213538 86955 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 550 10 1 4 5.7 COCCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
52947645 24015 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 24015 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52947647 24019 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256590 24019 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
44233185 201601 0 None 47 4 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL539193 201601 0 None 47 4 Human 9.8 pIC50 = 9.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
57397021 77733 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(C)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951624 77733 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 611 5 0 3 5.9 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(C)cc3)C2)CC1 10.1016/j.bmc.2011.11.048
46884471 14521 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089062 14521 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24768572 14541 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089270 14541 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24888942 14718 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 3 7.0 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090437 14718 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 569 5 0 3 7.0 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46883824 15205 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 1 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093597 15205 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 1 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44444640 100755 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.8 C[C@@H](O[C@@H]1CN(C(=O)C(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL248545 100755 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 487 4 0 2 6.8 C[C@@H](O[C@@H]1CN(C(=O)C(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444694 161604 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(C)(C)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL400393 161604 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 525 5 0 3 7.5 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(C)(C)CC2)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
9850771 126656 3 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL348976 126656 3 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
15253734 172128 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 563 10 2 4 4.8 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 10.1021/jm950616c
CHEMBL423623 172128 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 563 10 2 4 4.8 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 10.1021/jm950616c
46227362 209363 0 None 12 4 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL611926 209363 0 None 12 4 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44274166 87026 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 528 7 1 4 6.2 CC(=O)c1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
CHEMBL21385 87026 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 528 7 1 4 6.2 CC(=O)c1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
44412236 84914 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCc2nnc(O)n2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL210365 84914 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCc2nnc(O)n2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
22885699 87795 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 506 7 1 3 5.7 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL215373 87795 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 506 7 1 3 5.7 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
22885703 148204 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 7 1 3 5.9 CNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL384112 148204 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 7 1 3 5.9 CNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44357006 20497 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 575 8 1 6 5.7 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN(C)C)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL1195055 20497 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 575 8 1 6 5.7 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN(C)C)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL553778 20497 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 575 8 1 6 5.7 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN(C)C)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
44356378 32514 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 587 8 1 6 5.9 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN2CCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL135263 32514 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 587 8 1 6 5.9 C[C@@H](OC1OCCN(Cc2n[nH]nc2CN2CCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
10480465 215194 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL99792 215194 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
9892852 91155 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL22194 91155 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
24785717 128883 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596492 128883 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
18669097 106178 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 495 7 1 3 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL282725 106178 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 495 7 1 3 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
57402692 78385 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917869 78385 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963302 78385 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 531 8 2 8 2.3 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@@H]1CCN(C(=O)CNC(C)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
57402221 77798 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
CHEMBL1951814 77798 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 561 4 1 3 4.8 Cc1cc(F)ccc1[C@H]1CN(C(=O)C(N)=O)CC[C@@H]1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.11.048
22885697 148450 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL385463 148450 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
44433394 153436 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL392368 153436 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 406 6 2 3 5.1 COc1ccc(C(C)(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
2102 7972 21 None -2 2 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00016a014
5311057 7972 21 None -2 2 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00016a014
CHEMBL441225 7972 21 None -2 2 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00016a014
9892852 91155 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL22194 91155 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
10553959 194649 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL49638 194649 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
104943 62160 39 None 1862 3 Human 9.7 pIC50 = 9.7 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00066a015
CHEMBL16192 62160 39 None 1862 3 Human 9.7 pIC50 = 9.7 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00066a015
9796216 109020 15 None - 0 Human 9.7 pIC50 = 9.7 Binding
Tested for inhibitory activity against substance P receptor.Tested for inhibitory activity against substance P receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@@H]1CCCN[C@@H]1c1ccccc1 10.1016/S0960-894X(01)81021-0
CHEMBL303118 109020 15 None - 0 Human 9.7 pIC50 = 9.7 Binding
Tested for inhibitory activity against substance P receptor.Tested for inhibitory activity against substance P receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@@H]1CCCN[C@@H]1c1ccccc1 10.1016/S0960-894X(01)81021-0
44294293 195232 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Tested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsTested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 429 4 0 2 6.1 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL50270 195232 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Tested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsTested for inhibitory concentration expressed as displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 429 4 0 2 6.1 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
10098209 105865 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL280662 105865 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 520 6 1 3 6.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
57402265 77737 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 639 6 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C(C)C)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951628 77737 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 639 6 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccccc3C(C)C)C2)CC1 10.1016/j.bmc.2011.11.048
44433797 152914 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391964 152914 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 615 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
52948868 24020 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256591 24020 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 5 1 3 6.5 CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
46883879 14542 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089271 14542 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 626 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44593636 188399 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
CHEMBL477365 188399 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
11814040 85584 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 601 8 1 6 6.3 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN2CCCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL2112743 85584 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 601 8 1 6 6.3 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN2CCCC2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
9871891 12231 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
CHEMBL107482 12231 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
9871891 12231 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm0311487
CHEMBL107482 12231 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 537 4 0 4 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm0311487
11318556 100710 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL24829 100710 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
9871414 105773 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ncc21 10.1016/s0960-894x(01)00182-2
CHEMBL279977 105773 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ncc21 10.1016/s0960-894x(01)00182-2
44274253 179056 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 564 6 1 3 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Br)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL447473 179056 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 564 6 1 3 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Br)ccc21 10.1016/s0960-894x(01)00182-2
10099787 110289 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.4 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCCO3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085129 110289 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.4 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCCO3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
10480465 215194 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL99792 215194 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 1 4 5.8 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nc[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44412245 84732 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCn2c(O)nnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL209657 84732 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 503 4 1 5 6.0 C[C@@H](O[C@H]1CCn2c(O)nnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44444689 101000 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249938 101000 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
24755076 98358 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 408 6 2 5 3.4 COc1ccc(OC(F)(F)F)cc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2COC[C@@H]12 10.1016/j.bmcl.2007.10.010
CHEMBL240706 98358 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 408 6 2 5 3.4 COc1ccc(OC(F)(F)F)cc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2COC[C@@H]12 10.1016/j.bmcl.2007.10.010
44412445 84694 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.2 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CNC1=O 10.1016/j.bmcl.2006.02.080
CHEMBL209456 84694 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.2 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CNC1=O 10.1016/j.bmcl.2006.02.080
135405092 146061 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 2 5 6.2 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2n[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL379137 146061 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 2 5 6.2 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2n[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
3086681 9052 17 None 89125 3 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1016/s0960-894x(01)00250-5
3510 9052 17 None 89125 3 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1016/s0960-894x(01)00250-5
CHEMBL42407 9052 17 None 89125 3 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1016/s0960-894x(01)00250-5
10257218 31611 3 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL134500 31611 3 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
10460917 170528 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL420543 170528 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9871754 12181 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 12181 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
10101238 41616 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 528 7 0 3 5.9 O=C(CN1CCCC1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL143156 41616 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 528 7 0 3 5.9 O=C(CN1CCCC1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL1651026 215605 24 None - 1 Human 9.6 pIC50 = 9.6 Binding
Binding affinity to human NK1 receptor by radioligand displacement assayBinding affinity to human NK1 receptor by radioligand displacement assay
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2013.03.016
44407370 81226 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 619 11 3 6 5.4 O=S(=O)(NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1)c1ccccc1 10.1016/j.bmcl.2005.11.026
CHEMBL202775 81226 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 619 11 3 6 5.4 O=S(=O)(NCC1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1)c1ccccc1 10.1016/j.bmcl.2005.11.026
22885698 146123 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 8 1 3 6.1 CCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL379289 146123 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 520 8 1 3 6.1 CCN(CC(N)=O)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44444629 100874 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 449 5 0 2 5.6 C[C@@H](O[C@@H]1CN(C=O)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249143 100874 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 449 5 0 2 5.6 C[C@@H](O[C@@H]1CN(C=O)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
9871754 12181 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 12181 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
5757 10758 12 None - 1 Human 9.6 pIC50 = 9.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
9832383 10758 12 None - 1 Human 9.6 pIC50 = 9.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
CHEMBL522987 10758 12 None - 1 Human 9.6 pIC50 = 9.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
DB11949 10758 12 None - 1 Human 9.6 pIC50 = 9.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmc.2013.09.001
58993578 128884 0 None - 0 Mongolian jird 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 478 7 0 3 6.8 CCN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596493 128884 0 None - 0 Mongolian jird 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 478 7 0 3 6.8 CCN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
9891865 86832 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 493 8 1 3 6.5 COCCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL212991 86832 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 493 8 1 3 6.5 COCCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
22885692 86953 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 449 5 1 2 6.5 CN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL213515 86953 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 449 5 1 2 6.5 CN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44415869 87468 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL215147 87468 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 546 7 1 3 6.5 C[C@@H](O[C@H]1CC[C@@H](N(C)C[C@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
22885691 88091 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 6 1 2 6.9 CCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL215889 88091 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 6 1 2 6.9 CCN[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
10951720 85582 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 547 7 2 6 5.1 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
CHEMBL2112741 85582 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 547 7 2 6 5.1 C[C@@H](O[C@H]1OCCN(Cc2nn[nH]c2CN)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0109558
10369373 168739 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 519 4 0 4 5.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
CHEMBL415705 168739 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 519 4 0 4 5.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
24992986 191083 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 489 4 0 2 7.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL484133 191083 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 489 4 0 2 7.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44294659 110291 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 624 6 1 3 8.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCC(C3CCOC3(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085131 110291 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 624 6 1 3 8.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCC(C3CCOC3(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
9869697 71415 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 478 8 1 5 4.3 COc1ccc(NS(C)(=O)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817895 71415 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 478 8 1 5 4.3 COc1ccc(NS(C)(=O)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
10341570 127852 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL357012 127852 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
2098 10466 36 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
36511 10466 36 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
3805 10466 36 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
3835 10466 36 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
CHEMBL235363 10466 36 None 1 6 Human 9.6 pIC50 = 9.6 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
44274153 84655 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 512 7 1 3 6.7 C=Cc1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
CHEMBL20937 84655 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 512 7 1 3 6.7 C=Cc1ccc2c(c1)c(CCC(=O)N1CCC(O)(Cc3ccccc3)CC1)c(-c1ccc(Cl)cc1)n2C 10.1016/s0960-894x(01)00182-2
135529973 128288 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 448 6 2 6 4.2 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cccc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL358343 128288 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 448 6 2 6 4.2 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(O)n2)[C@H]1c1ccccc1)c1cccc(C(F)(F)F)c1 10.1021/jm980299k
44407459 147889 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 633 10 3 7 4.9 O=C(NS(=O)(=O)c1ccccc1)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL382720 147889 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 633 10 3 7 4.9 O=C(NS(=O)(=O)c1ccccc1)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
44456524 104714 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL272569 104714 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@H]1CN2C(=O)OC[C@@H]2[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44416008 87277 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 557 7 1 3 6.7 C[C@@H](O[C@H]1CC[C@@H](N(C)C(=O)Cc2c[nH]cn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214748 87277 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 557 7 1 3 6.7 C[C@@H](O[C@H]1CC[C@@H](N(C)C(=O)Cc2c[nH]cn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46884470 14766 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090652 14766 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 580 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24752568 15684 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 15684 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
18407037 169038 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL416372 169038 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
18407037 169038 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL416372 169038 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 0 4 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
44412173 85016 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCc2nccn2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL210630 85016 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCc2nccn2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44456700 102684 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL259251 102684 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44415789 148443 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 9 1 4 5.6 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)CCO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL385414 148443 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 9 1 4 5.6 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)CCO)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
10144275 25665 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.7 Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL128369 25665 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.7 Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
22293490 108087 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(NC(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL296583 108087 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(NC(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
24785717 128883 0 None - 0 Mongolian jird 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596492 128883 0 None - 0 Mongolian jird 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 0 3 6.4 CN1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
44356404 29980 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 561 8 2 6 5.4 CNCc1n[nH]nc1CN1CCOC(O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1 10.1021/jm0109558
CHEMBL133140 29980 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 561 8 2 6 5.4 CNCc1n[nH]nc1CN1CCOC(O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1 10.1021/jm0109558
18669091 11457 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 0 3 6.4 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL103367 11457 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 0 3 6.4 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10008129 67852 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 11 2 3 6.3 O=C(CCCN1CCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL176500 67852 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 11 2 3 6.3 O=C(CCCN1CCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9938284 108192 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 584 5 1 4 6.6 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CC2)OCCO3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL297344 108192 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 584 5 1 4 6.6 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CC2)OCCO3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
11755227 209855 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 488 6 0 3 5.5 CN(C)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63793 209855 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 488 6 0 3 5.5 CN(C)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
71450870 85434 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 407 4 1 4 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN[C@H]2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL2112368 85434 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 407 4 1 4 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN[C@H]2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
22885695 145902 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 10 1 4 6.0 COCCNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL378689 145902 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 564 10 1 4 6.0 COCCNC(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
46881600 13878 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 493 5 1 3 5.3 CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO 10.1016/j.bmcl.2010.01.065
CHEMBL1085196 13878 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 493 5 1 3 5.3 CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO 10.1016/j.bmcl.2010.01.065
44444689 101000 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249938 101000 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 517 5 1 4 5.6 C[C@@H](O[C@@H]1CN(C2=CC(=O)C(O)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44444671 161535 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 575 4 0 3 5.7 CC(=O)N1CCN(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
CHEMBL400060 161535 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 575 4 0 3 5.7 CC(=O)N1CCN(C(=O)N2C[C@@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 10.1016/j.bmcl.2007.06.085
57402688 78381 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 438 6 1 5 4.3 COC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917843 78381 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 438 6 1 5 4.3 COC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963298 78381 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 438 6 1 5 4.3 COC(=O)N1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
52941489 24503 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258623 24503 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10768417 172381 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 525 7 0 4 5.7 O=C(Cn1ccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL424291 172381 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 525 7 0 4 5.7 O=C(Cn1ccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL1651026 215605 24 None - 1 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to human NK1 receptor by radioligand displacement assayBinding affinity to human NK1 receptor by radioligand displacement assay
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.ejmech.2013.01.044
58993533 128876 0 None - 0 Mongolian jird 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1c(F)cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596485 128876 0 None - 0 Mongolian jird 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1c(F)cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
19797422 103438 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 523 6 0 2 6.4 Cc1cc(I)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL263795 103438 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 523 6 0 2 6.4 Cc1cc(I)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
104943 62160 39 None 1862 3 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00148-5
CHEMBL16192 62160 39 None 1862 3 Human 9.5 pIC50 = 9.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00148-5
10346229 89797 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 509 7 0 4 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21813 89797 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 509 7 0 4 6.6 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)C)cc3)n(C)c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
21955317 110290 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 632 7 2 3 7.9 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(O)(Cc3ccccc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085130 110290 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 632 7 2 3 7.9 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(O)(Cc3ccccc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
44412374 84569 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@H]1[C@H](c2ccc(F)cc2)[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCC(=O)N1C 10.1016/j.bmcl.2006.02.080
CHEMBL209240 84569 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@H]1[C@H](c2ccc(F)cc2)[C@@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCC(=O)N1C 10.1016/j.bmcl.2006.02.080
11678857 146085 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.6 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL379224 146085 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.6 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
44456865 104679 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL272469 104679 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
14986135 170180 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm058225d
CHEMBL419500 170180 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm058225d
44334275 11844 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 485 7 0 3 6.3 CC(C)CCN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL105420 11844 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 485 7 0 3 6.3 CC(C)CCN1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
9871754 12181 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 12181 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
10415870 110287 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085127 110287 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
10483816 197977 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
CHEMBL51893 197977 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
10483816 86405 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115007 86405 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
10415870 147387 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
CHEMBL381390 147387 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 582 5 1 3 7.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
53379508 73235 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 469 7 0 4 5.8 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817891 73235 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 469 7 0 4 5.8 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852123 73235 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 469 7 0 4 5.8 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
22885696 145706 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 532 7 2 3 6.1 C[C@@H](O[C@H]1CC[C@@H](NC[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL378416 145706 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 532 7 2 3 6.1 C[C@@H](O[C@H]1CC[C@@H](NC[C@@H]2CCC(=O)N2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
44444654 100832 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 5 1 4 5.0 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2COC(=O)N2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL248943 100832 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 534 5 1 4 5.0 C[C@@H](O[C@@H]1CN(C(=O)[C@@H]2COC(=O)N2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
15516313 185496 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 434 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@@](C)(C(F)(F)F)OCC2 10.1016/j.bmc.2008.06.047
CHEMBL468350 185496 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 434 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@@](C)(C(F)(F)F)OCC2 10.1016/j.bmc.2008.06.047
44593636 188399 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
CHEMBL477365 188399 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 432 5 2 3 5.4 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C)(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
9871754 12181 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
CHEMBL107172 12181 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
10698096 62647 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL162337 62647 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
9871754 12181 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 12181 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
44334149 11371 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 497 5 0 3 6.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(C3CCCCC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102730 11371 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 497 5 0 3 6.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(C3CCCCC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10393962 110292 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 5 1 3 8.2 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CC2)CCC(C)(C)O3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085132 110292 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 5 1 3 8.2 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC3(CC2)CCC(C)(C)O3)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
22293475 193907 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL49176 193907 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
18782542 118242 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 4 4.9 COc1ccc(OC(F)(F)F)cc1C1=CC2(CCCNC2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
CHEMBL327606 118242 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 4 4.9 COc1ccc(OC(F)(F)F)cc1C1=CC2(CCCNC2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
11146618 85583 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 631 10 1 6 7.3 CC(C)N(Cc1[nH]nnc1CN1CCO[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1)C(C)C 10.1021/jm0109558
CHEMBL2112742 85583 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1In vitro inhibition of binding of [125I]-substance P to tachykinin receptor 1
ChEMBL 631 10 1 6 7.3 CC(C)N(Cc1[nH]nnc1CN1CCO[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccc(F)cc1)C(C)C 10.1021/jm0109558
104943 62160 39 None 1862 3 Human 9.5 pIC50 = 9.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 62160 39 None 1862 3 Human 9.5 pIC50 = 9.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
44346234 21419 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 4 0 3 3.7 COc1ccccc1CN1CCN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
CHEMBL120523 21419 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 4 0 3 3.7 COc1ccccc1CN1CCN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
10415534 172985 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 3 3 6.2 O=C(CCC1CCNCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL426577 172985 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 3 3 6.2 O=C(CCC1CCNCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
2098 10466 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
36511 10466 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
3805 10466 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
3835 10466 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
CHEMBL235363 10466 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
22885704 88300 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 576 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCOCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL216018 88300 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 576 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCOCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24752568 15684 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1097693 15684 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24752568 15684 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 15684 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44444659 100947 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 4 0 2 6.1 C[C@@H](O[C@@H]1CN(C(=O)N(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL249568 100947 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 492 4 0 2 6.1 C[C@@H](O[C@@H]1CN(C(=O)N(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
9855000 27393 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL130834 27393 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
18669080 11780 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 519 6 0 3 6.0 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)C(=O)C2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL105047 11780 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 519 6 0 3 6.0 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(Cc3ccccc3)C(=O)C2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10210026 108137 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 569 6 1 3 6.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(C(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL296979 108137 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 569 6 1 3 6.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(C(C)C)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
58993465 128885 0 None - 0 Mongolian jird 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 492 7 0 3 7.2 CC(C)N1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596494 128885 0 None - 0 Mongolian jird 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 492 7 0 3 7.2 CC(C)N1CCC(COCc2cc(-c3ccc(C#N)cc3)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2015.04.098
22885702 87282 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 7 0 3 6.3 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214761 87282 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 534 7 0 3 6.3 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N(C)C)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46884434 14697 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 593 6 1 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090288 14697 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 593 6 1 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44346438 121528 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 564 8 0 3 7.1 CN(Cc1ccccc1)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
CHEMBL333882 121528 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 564 8 0 3 7.1 CN(Cc1ccccc1)C(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
10098987 66755 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173396 66755 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 62160 39 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00035a006
CHEMBL16192 62160 39 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00035a006
104943 62160 39 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950654w
CHEMBL16192 62160 39 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950654w
44410317 83925 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 543 5 1 6 5.6 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2(F)c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL207794 83925 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 543 5 1 6 5.6 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2(F)c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44415921 148525 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 492 7 2 3 5.3 C[C@@H](O[C@H]1CC[C@@H](NCC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL385925 148525 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 492 7 2 3 5.3 C[C@@H](O[C@H]1CC[C@@H](NCC(N)=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24889458 15202 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 6 0 5 6.7 CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1093594 15202 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 583 6 0 5 6.7 CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
46947062 24232 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 24232 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rat serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46947062 24232 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 24232 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% rhesus monkey serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
9821217 114507 21 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL319118 114507 21 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL3215877 114507 21 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 380 6 2 4 4.2 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
44593633 189221 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
CHEMBL478620 189221 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
44577989 196209 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 392 6 2 3 4.9 COc1ccc(C(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL513351 196209 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 392 6 2 3 4.9 COc1ccc(C(C)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
9984665 12114 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 536 4 0 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL106864 12114 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 536 4 0 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
104943 62160 39 None - 3 Guinea pig 9.4 pIC50 = 9.4 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 62160 39 None - 3 Guinea pig 9.4 pIC50 = 9.4 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
2098 10466 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
36511 10466 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
3805 10466 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
3835 10466 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
CHEMBL235363 10466 36 None -1 6 Rat 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm070577s
44412493 84669 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CC(=O)N1 10.1016/j.bmcl.2006.02.080
CHEMBL209407 84669 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 2 6.4 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CC(=O)N1 10.1016/j.bmcl.2006.02.080
44415909 86661 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 545 7 2 4 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2c[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL212349 86661 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 545 7 2 4 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)Cc2c[nH]c(O)n2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
49863732 22103 0 None 24 4 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214025 22103 0 None 24 4 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
135430679 52819 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 408 8 2 5 4.5 Cc1cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)cc(C(C)(C)C)c1 10.1016/s0960-894x(97)10163-9
CHEMBL153310 52819 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 408 8 2 5 4.5 Cc1cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)cc(C(C)(C)C)c1 10.1016/s0960-894x(97)10163-9
44294660 110293 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 6 1 4 7.1 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCOC3=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085133 110293 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 6 1 4 7.1 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCOC3=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
53379509 73230 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 427 7 0 3 6.0 COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817892 73230 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 427 7 0 3 6.0 COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852099 73230 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 427 7 0 3 6.0 COc1ccc(C(C)C)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
44433789 152912 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391963 152912 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
24750888 15223 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093751 15223 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 504 4 1 3 5.4 C[C@@H](O[C@H]1CN2C(=O)CC(C)(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
135430775 52119 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 474 8 2 5 4.9 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL152685 52119 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 474 8 2 5 4.9 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
44412235 146953 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCn2ccnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL380388 146953 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 486 4 0 3 6.9 C[C@@H](O[C@H]1CCn2ccnc2C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
44415808 88236 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL215975 88236 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 560 7 0 3 6.8 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCCC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
11756257 174562 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL43044 174562 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
18669059 105546 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 1 3 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL278149 105546 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 521 6 1 3 6.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(F)(F)F)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44412373 145878 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.6 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CN(C)C1=O 10.1016/j.bmcl.2006.02.080
CHEMBL378663 145878 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.6 C[C@@H]1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)CN(C)C1=O 10.1016/j.bmcl.2006.02.080
21955285 195773 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)C(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL50867 195773 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 636 7 2 3 7.8 O=C(N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)C(CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
104943 62160 39 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
CHEMBL16192 62160 39 None 1862 3 Human 9.4 pIC50 = 9.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
24785978 128874 0 None - 0 Mongolian jird 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596483 128874 0 None - 0 Mongolian jird 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
9329 10513 5 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1016/j.bmc.2011.07.014
9894349 10513 5 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1016/j.bmc.2011.07.014
CHEMBL339486 10513 5 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1016/j.bmc.2011.07.014
9329 10513 5 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
9894349 10513 5 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
CHEMBL339486 10513 5 None - 0 Human 9.4 pIC50 = 9.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
10392469 201634 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL539928 201634 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
44177669 68035 0 None 2 4 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766205 68035 0 None 2 4 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
10325507 67216 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 561 10 2 3 6.5 O=C(CCc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL175224 67216 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 561 10 2 3 6.5 O=C(CCc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
44444674 101100 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 639 4 0 5 6.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCn3c(nnc3C(F)(F)F)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL250596 101100 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 639 4 0 5 6.7 C[C@@H](O[C@@H]1CN(C(=O)N2CCn3c(nnc3C(F)(F)F)C2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44408291 147658 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 677 5 0 3 8.1 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4Cl)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL381984 147658 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 677 5 0 3 8.1 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4Cl)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
44408177 147753 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 4 7.1 COC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL382331 147753 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 624 5 0 4 7.1 COC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
44408290 148027 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.4 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
CHEMBL383048 148027 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.4 CC1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN([C@]2(c3ccccc3)CC[C@@H](N3CCN(c4ccccc4)C(=O)C3)CC2)C1=O 10.1016/j.bmcl.2005.11.111
10007758 185760 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 551 12 2 6 4.5 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL47070 185760 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 551 12 2 6 4.5 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
104943 62160 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL16192 62160 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
46227363 206444 0 None 28 4 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL592969 206444 0 None 28 4 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44412453 168468 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@@H](O[C@H]1C[C@@H](C)N(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL413279 168468 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 491 4 0 2 6.7 C[C@@H](O[C@H]1C[C@@H](C)N(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
21955222 108560 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL300014 108560 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
10392469 201634 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
CHEMBL539928 201634 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
2102 7972 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00006a012
5311057 7972 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00006a012
CHEMBL441225 7972 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00006a012
10098987 66755 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173396 66755 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 62160 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
CHEMBL16192 62160 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
10720240 41870 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 502 7 0 3 5.4 CN(C)CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL143375 41870 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 502 7 0 3 5.4 CN(C)CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
2102 7972 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
5311057 7972 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL441225 7972 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
104943 62160 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80534-5
CHEMBL16192 62160 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80534-5
2102 7972 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9506534
5311057 7972 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9506534
CHEMBL441225 7972 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm9506534
2102 7972 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm950654w
5311057 7972 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm950654w
CHEMBL441225 7972 21 None -2 2 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm950654w
105083 32223 3 None - 1 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
CHEMBL135022 32223 3 None - 1 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 10.1021/jm980299k
44410278 147642 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL381965 147642 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnn(C)n1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44408176 81098 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 594 4 0 3 7.4 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
CHEMBL202439 81098 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 594 4 0 3 7.4 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
104943 62160 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80349-2
CHEMBL16192 62160 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80349-2
44593634 189568 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 418 5 2 3 5.3 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
CHEMBL479049 189568 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 418 5 2 3 5.3 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CCC2 10.1016/j.bmc.2008.06.047
10099939 11759 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL104954 11759 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
9830304 114124 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 608 7 2 4 5.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12 10.1016/s0960-894x(01)00631-x
CHEMBL317632 114124 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 608 7 2 4 5.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12 10.1016/s0960-894x(01)00631-x
10099939 11759 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL104954 11759 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
104943 62160 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80747-2
CHEMBL16192 62160 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80747-2
104943 62160 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00080-D
CHEMBL16192 62160 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00080-D
10814682 214493 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL95626 214493 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44433798 152464 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391615 152464 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 643 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
46884468 14764 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 3 7.5 Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL1090650 14764 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 3 7.5 Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
104943 62160 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL16192 62160 39 None 1862 3 Human 9.3 pIC50 = 9.3 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
44415896 145692 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 507 8 0 3 6.8 COCCN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL378331 145692 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 507 8 0 3 6.8 COCCN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
44299271 202827 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL56038 202827 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
42639649 177524 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 553 5 0 4 7.4 C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL445239 177524 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin
ChEMBL 553 5 0 4 7.4 C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44334107 11177 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 532 6 0 3 7.2 CC(=O)C1(c2ccccc2)CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL101421 11177 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 532 6 0 3 7.2 CC(=O)C1(c2ccccc2)CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
44299271 202827 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL56038 202827 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
10814682 214493 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL95626 214493 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ncc[nH]3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44412159 147699 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCN(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL382255 147699 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 477 4 0 2 6.3 C[C@@H](O[C@H]1CCN(C)C(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
46884430 15092 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1092755 15092 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 487 4 0 2 6.3 C[C@@H](O[C@H]1CN2C(=O)C=CCC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
22901329 105855 1 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
CHEMBL28055 105855 1 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
9805809 109864 8 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm00022a010
CHEMBL307488 109864 8 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm00022a010
44334127 11406 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 522 6 0 2 7.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(F)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102937 11406 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 522 6 0 2 7.7 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(F)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
44415554 145827 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 515 7 2 3 6.8 C[C@@H](O[C@H]1CC[C@@H](NCc2ncc[nH]2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL378609 145827 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 515 7 2 3 6.8 C[C@@H](O[C@H]1CC[C@@H](NCc2ncc[nH]2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
136094860 212890 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 454 5 2 7 3.2 COc1ccccc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL85792 212890 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 454 5 2 7 3.2 COc1ccccc1[C@H]1COCC2(C1)OCCN(Cc1n[nH]c(O)n1)[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44433796 96967 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 5.3 Cc1cnc(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
CHEMBL238220 96967 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 5.3 Cc1cnc(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
44444677 161762 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 545 6 2 4 5.4 C[C@@H](O[C@@H]1CN(C(=O)NCc2cn[nH]n2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL401281 161762 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 545 6 2 4 5.4 C[C@@H](O[C@@H]1CN(C(=O)NCc2cn[nH]n2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
44312057 211231 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 690 7 2 5 7.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL72234 211231 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 690 7 2 5 7.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
24785978 128874 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596483 128874 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 450 6 1 3 6.1 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
10392925 21211 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL120081 21211 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
10076669 66992 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 2 3 6.3 O=C(CCN1CCCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL174016 66992 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 567 10 2 3 6.3 O=C(CCN1CCCCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
11800025 128058 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 516 8 0 3 5.8 CN(C)CCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL357887 128058 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 516 8 0 3 5.8 CN(C)CCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
18669082 172495 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL424586 172495 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
18669082 172495 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL424586 172495 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 3 6.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL2115376 216046 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
2102 7972 21 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
5311057 7972 21 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL441225 7972 21 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
44410191 147470 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 583 6 1 4 7.1 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2S(=O)(=O)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL381555 147470 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 583 6 1 4 7.1 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2S(=O)(=O)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44415947 87078 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2cccnc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214118 87078 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2cccnc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24750734 14785 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1090742 14785 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24750734 14785 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 14785 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
2102 7972 21 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
5311057 7972 21 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
CHEMBL441225 7972 21 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm0311487
44305288 209658 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 530 4 1 3 6.8 CN(O)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL62649 209658 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 530 4 1 3 6.8 CN(O)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
10392925 21211 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL120081 21211 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 555 12 2 3 6.2 CN(C)CCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
18686789 99749 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCCC1C2c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL2441369 99749 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCCC1C2c1ccccc1 10.1016/j.bmc.2013.09.001
136094778 146039 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 515 8 4 6 3.8 O=c1nc(C2CC3(c4ccccc4)NC2CCC3NCc2cc(OC(F)(F)F)ccc2OC2CC2)[nH][nH]1 10.1016/j.bmcl.2005.11.026
CHEMBL379010 146039 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 515 8 4 6 3.8 O=c1nc(C2CC3(c4ccccc4)NC2CCC3NCc2cc(OC(F)(F)F)ccc2OC2CC2)[nH][nH]1 10.1016/j.bmcl.2005.11.026
10357939 124857 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
CHEMBL340559 124857 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 308 4 0 3 3.7 COc1ccccc1CN1CN2CCC[C@H]1[C@@H]2c1ccccc1 10.1021/jm9700171
44294291 107967 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL295685 107967 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 634 6 1 2 9.0 CC(C)(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44408158 146957 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 617 6 1 3 7.1 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(c3ccccc3)C(=O)C2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
CHEMBL380408 146957 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 617 6 1 3 7.1 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCN(c3ccccc3)C(=O)C2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
56662745 71417 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817889 71417 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817897 71417 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
10258336 108059 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL296397 108059 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
44307416 209787 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 6 1 3 5.2 CNC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63240 209787 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 6 1 3 5.2 CNC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
10258336 108059 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL296397 108059 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44456703 165133 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL408960 165133 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
2102 7972 21 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.10.010
5311057 7972 21 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.10.010
CHEMBL441225 7972 21 None -2 2 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmcl.2007.10.010
2098 10466 36 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
36511 10466 36 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
3805 10466 36 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
3835 10466 36 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
CHEMBL235363 10466 36 None -1 6 Rat 9.2 pIC50 = 9.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None None 10.1021/jm00037a009
44412225 146487 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCNC(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL379816 146487 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I] labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 463 4 1 2 6.0 C[C@@H](O[C@H]1CCNC(=O)C[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.02.080
CHEMBL5269970 200392 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomesInhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomes
ChEMBL 1252 41 16 16 -2.3 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)O 10.1021/acs.jmedchem.6b01029
44407431 80004 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 500 8 3 7 3.9 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3NC2(c2ccccc2)CC3c2nnn[nH]2)c1 10.1016/j.bmcl.2005.11.026
CHEMBL201192 80004 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 500 8 3 7 3.9 FC(F)(F)Oc1ccc(OC2CC2)c(CNC2CCC3NC2(c2ccccc2)CC3c2nnn[nH]2)c1 10.1016/j.bmcl.2005.11.026
10076383 108003 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 555 11 2 5 5.2 CC(=O)N(Cc1ccccc1Cl)C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1 10.1016/s0960-894x(01)00250-5
CHEMBL296013 108003 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 555 11 2 5 5.2 CC(=O)N(Cc1ccccc1Cl)C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-n2ccnc2)cc1 10.1016/s0960-894x(01)00250-5
104943 62160 39 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2013.09.001
CHEMBL16192 62160 39 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2013.09.001
44408313 81277 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 610 4 1 4 6.5 O=C1N([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)CCC1(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
CHEMBL202884 81277 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 610 4 1 4 6.5 O=C1N([C@]2(c3ccccc3)CC[C@@H](N3CCC4(CCOC4)CC3)CC2)CCC1(O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.111
52941550 24576 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258852 24576 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
104943 62160 39 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL16192 62160 39 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44433784 96965 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 540 5 0 2 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL238210 96965 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 540 5 0 2 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
44416136 86582 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 578 10 0 4 6.3 COCCN(C)C(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
CHEMBL212025 86582 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 578 10 0 4 6.3 COCCN(C)C(=O)CN(C)[C@@H]1CC[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccc(F)cc1 10.1016/j.bmcl.2006.06.044
9855000 27393 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL130834 27393 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
10347274 135451 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 541 11 2 3 5.8 CN(C)CCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL366818 135451 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 541 11 2 3 5.8 CN(C)CCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 62160 39 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80280-8
CHEMBL16192 62160 39 None 1862 3 Human 9.2 pIC50 = 9.2 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80280-8
21955298 86404 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115006 86404 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL396426 219275 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
44415967 145479 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2ccncc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL377917 145479 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 526 7 1 3 7.4 C[C@@H](O[C@H]1CC[C@@H](NCc2ccncc2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
46947062 24232 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 24232 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10502796 39088 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL141034 39088 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
44578024 185473 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 396 6 2 3 4.9 COc1ccc(C(F)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL468163 185473 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 396 6 2 3 4.9 COc1ccc(C(F)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
10372941 126286 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 757 14 1 5 8.2 COc1ccccc1CN(C)CCNC(=O)[C@@H]1C[C@@H](C(=O)N(Cc2ccccc2)Cc2ccccc2)CCN1C(=O)N(c1ccccc1)c1cccc(Cl)c1 10.1016/0960-894X(95)00080-D
CHEMBL345520 126286 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 757 14 1 5 8.2 COc1ccccc1CN(C)CCNC(=O)[C@@H]1C[C@@H](C(=O)N(Cc2ccccc2)Cc2ccccc2)CCN1C(=O)N(c1ccccc1)c1cccc(Cl)c1 10.1016/0960-894X(95)00080-D
10885893 109689 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 525 10 3 5 5.6 COC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL306089 109689 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 525 10 3 5 5.6 COC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
10553959 194649 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL49638 194649 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
44305221 107805 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 551 8 3 6 4.7 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL294545 107805 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 551 8 3 6 4.7 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
10553959 194649 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL49638 194649 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44313273 211748 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 481 8 3 4 5.6 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL76501 211748 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 481 8 3 4 5.6 C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
44433793 155163 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cnccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL393746 155163 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cnccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL396426 219275 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
22293505 196308 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 623 8 1 3 8.7 OCC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL51417 196308 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 623 8 1 3 8.7 OCC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
25028925 98140 4 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
CHEMBL2402572 98140 4 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
44358731 37113 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 1 3 7.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139167 37113 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 1 3 7.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10077113 128321 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL35857 128321 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
104943 62160 39 None 1862 3 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL16192 62160 39 None 1862 3 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
22293475 193907 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL49176 193907 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44415444 86997 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 418 5 1 2 5.8 OC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213726 86997 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 418 5 1 2 5.8 OC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
52949827 24114 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257357 24114 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24750734 14785 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 14785 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL229280 216237 0 None 23 3 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC[S+](C)[O-])NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
44333607 11747 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 469 6 0 3 5.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL104883 11747 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 469 6 0 3 5.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10142159 88319 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 4 5.8 O=C(CCc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12)N1CCC(O)(Cc2ccccc2)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21607 88319 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 4 5.8 O=C(CCc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12)N1CCC(O)(Cc2ccccc2)CC1 10.1016/s0960-894x(01)00182-2
44274180 169970 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 552 7 1 4 7.3 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccco3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL418186 169970 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 552 7 1 4 7.3 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccco3)ccc21 10.1016/s0960-894x(01)00182-2
44433787 95307 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 1 2 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)NC2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL235219 95307 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 555 5 1 2 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)NC2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
11800024 215036 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL98811 215036 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
136180340 126387 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 488 9 2 5 5.3 CCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL346447 126387 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 488 9 2 5 5.3 CCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10053205 123363 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL336589 123363 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
11800024 215036 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL98811 215036 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 6.1 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3n[nH]c(S)n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44408123 147365 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.8 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
CHEMBL381362 147365 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 608 4 0 3 7.8 O=C1C(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCN1[C@]1(c2ccccc2)CC[C@@H](N2CCC3(CCOC3)CC2)CC1 10.1016/j.bmcl.2005.11.111
46881682 14869 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 14869 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
104943 62160 39 None 1862 3 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL16192 62160 39 None 1862 3 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
10578351 127006 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 539 12 2 5 3.7 COc1ccccc1CN(C=O)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL352176 127006 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 539 12 2 5 3.7 COc1ccccc1CN(C=O)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
71449072 85353 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 645 5 2 3 7.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00382-7
CHEMBL2112212 85353 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 645 5 2 3 7.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00382-7
56668401 73217 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 505 7 0 4 6.1 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817890 73217 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 505 7 0 4 6.1 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852009 73217 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 505 7 0 4 6.1 COc1ccc(OC(F)(F)F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
44415404 86816 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 514 7 1 3 5.8 CN(C[C@@H]1CCC(=O)N1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212931 86816 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 514 7 1 3 5.8 CN(C[C@@H]1CCC(=O)N1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
10721713 126815 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.5 CCC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL350381 126815 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.5 CCC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
18709649 171785 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42259 171785 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 3 5 3.8 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(CO)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
44415550 172915 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL426145 172915 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46881820 14333 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1087695 14333 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(n3cnnc3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44433792 155161 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ncccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL393745 155161 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ncccn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
22901329 105855 1 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL28055 105855 1 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
22901329 105855 1 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL28055 105855 1 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 510 10 2 3 5.5 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44294689 108390 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 542 5 2 3 6.2 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL298858 108390 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 542 5 2 3 6.2 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
11016806 211736 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 523 10 3 4 6.8 CCC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL76455 211736 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 523 10 3 4 6.8 CCC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
9829083 126917 0 None - 1 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351274 126917 0 None - 1 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
10816374 25667 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 545 3 0 4 6.5 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL128384 25667 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 545 3 0 4 6.5 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
132846 104223 23 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
CHEMBL1256740 104223 23 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
CHEMBL27006 104223 23 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
132846 104223 23 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00790
CHEMBL1256740 104223 23 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00790
CHEMBL27006 104223 23 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00790
132846 104223 23 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL1256740 104223 23 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL27006 104223 23 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
135547943 41201 26 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
CHEMBL142819 41201 26 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 516 6 2 5 4.8 C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm980299k
44456828 104356 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 490 4 0 2 5.8 C[C@@H](O[C@H]1CN2C(=O)N(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL270751 104356 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 490 4 0 2 5.8 C[C@@H](O[C@H]1CN2C(=O)N(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44358610 36256 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 619 7 1 3 6.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138463 36256 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 619 7 1 3 6.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10531050 127130 0 None - 0 Guinea pig 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL353093 127130 0 None - 0 Guinea pig 9.1 pIC50 = 9.1 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
18669087 105506 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL277880 105506 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
18669087 105506 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL277880 105506 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
44325035 118930 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 488 6 1 6 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3nc[nH]n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL329018 118930 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 488 6 1 6 5.0 COc1ccc(OC(F)(F)F)cc1[C@H]1COC2(CCCN(Cc3nc[nH]n3)C2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
44415400 86868 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 461 5 1 3 5.9 COC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213134 86868 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 461 5 1 3 5.9 COC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
9938657 66996 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
CHEMBL174038 66996 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
10502796 39088 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL141034 39088 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 431 5 0 2 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
11799022 11239 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL101763 11239 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
46881727 12366 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077241 12366 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)C(NCc3ccn[nH]3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
15549737 185595 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 378 6 2 3 4.4 COc1ccc(CC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL469176 185595 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 378 6 2 3 4.4 COc1ccc(CC(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
44593633 189221 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
CHEMBL478620 189221 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 404 5 2 3 4.9 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)C(C(F)(F)F)CC2 10.1016/j.bmc.2008.06.047
44578056 196536 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 422 7 2 4 4.7 COc1ccc(C(C)(OC)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
CHEMBL515935 196536 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 422 7 2 4 4.7 COc1ccc(C(C)(OC)C(F)(F)F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/j.bmc.2008.06.047
19797472 125540 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 469 7 0 2 6.4 Cc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc([Si](C)(C)C)c1 10.1021/jm00024a007
CHEMBL341863 125540 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 469 7 0 2 6.4 Cc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc([Si](C)(C)C)c1 10.1021/jm00024a007
10341570 127852 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL357012 127852 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
2098 10466 36 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
36511 10466 36 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3805 10466 36 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3835 10466 36 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 10466 36 None 1 6 Human 9.1 pIC50 = 9.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
58993655 128877 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1cc(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596486 128877 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 486 6 1 3 6.4 N#Cc1cc(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
24752434 15905 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 15905 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL2370435 216628 0 None 48 2 Human 9.0 pIC50 = 9.0 Binding
Displacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptorDisplacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1021/jm8007618
15639110 174921 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 438 7 1 3 5.6 COc1ccccc1CN[C@H]1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL433020 174921 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 438 7 1 3 5.6 COc1ccccc1CN[C@H]1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44274544 88301 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 4 5.4 Cn1c(-c2cccnc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL21602 88301 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 4 5.4 Cn1c(-c2cccnc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
44328469 119017 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 438 7 1 3 5.6 COc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL329090 119017 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 438 7 1 3 5.6 COc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
24782914 128873 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 455 7 1 3 6.2 COc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596482 128873 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 455 7 1 3 6.2 COc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
46884431 14827 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 563 5 0 2 7.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1091043 14827 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 563 5 0 2 7.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10578269 41920 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccncc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL143464 41920 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccncc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
4898 9541 86 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
5742 9541 86 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
6451149 9541 86 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
CHEMBL206253 9541 86 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
DB09048 9541 86 None - 1 Human 9.0 pIC50 = 9.0 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmc.2013.09.001
10047566 172020 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL422931 172020 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
10047566 172020 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL422931 172020 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44415840 86741 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 589 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCN(C)CC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL212663 86741 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 589 7 0 4 6.0 C[C@@H](O[C@H]1CC[C@@H](N(C)CC(=O)N2CCN(C)CC2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
10049890 86787 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212839 86787 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
10047566 172020 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL422931 172020 3 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL389652 219209 0 None 2 4 Human 9.0 pIC50 = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
11813209 211878 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 509 9 3 4 6.4 CC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL77684 211878 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 509 9 3 4 6.4 CC[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
18669072 90092 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 551 8 1 5 5.9 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CCO)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21909 90092 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 551 8 1 5 5.9 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CCO)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
10576865 214906 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL98022 214906 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
44433810 96654 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL237796 96654 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmcl.2007.08.028
9959724 171634 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 569 12 2 7 4.9 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-c2csnn2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42191 171634 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 569 12 2 7 4.9 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(-c2csnn2)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
10531050 127130 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL353093 127130 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
489662 89802 2 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL21815 89802 2 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00616-3
132846 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(98)00320-5
CHEMBL1256740 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(98)00320-5
CHEMBL27006 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(98)00320-5
44297605 201466 0 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL53312 201466 0 None - 0 Human 9.0 pIC50 = 9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
132846 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL1256740 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL27006 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
9805809 109864 8 None - 0 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
CHEMBL307488 109864 8 None - 0 Human 9.0 pIC50 = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm501535r
44338517 13107 0 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL108200 13107 0 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
9938657 66996 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
CHEMBL174038 66996 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
132846 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL1256740 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL27006 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm980376b
44346206 120438 3 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL332284 120438 3 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm980376b
132846 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
CHEMBL1256740 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
CHEMBL27006 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
10047567 213998 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
CHEMBL92701 213998 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
9890435 104219 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL27003 104219 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
132846 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
CHEMBL1256740 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
CHEMBL27006 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
2102 7972 21 None -2 2 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80534-5
5311057 7972 21 None -2 2 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80534-5
CHEMBL441225 7972 21 None -2 2 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80534-5
44458328 106291 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL283356 106291 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
11799022 11239 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL101763 11239 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 1 3 6.4 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3c[nH]cn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
132846 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL1256740 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL27006 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44458328 106291 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL283356 106291 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
44346206 120438 3 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL332284 120438 3 None - 1 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1021/jm9700171
10576865 214906 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL98022 214906 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 485 6 0 5 6.0 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nnco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
10648551 215206 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL99873 215206 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
132846 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL1256740 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL27006 104223 23 None - 0 Human 9.0 pIC50 = 9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
489662 89802 2 None - 0 Human 9.0 pIC50 = 9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21815 89802 2 None - 0 Human 9.0 pIC50 = 9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00182-2
489662 89802 2 None - 0 Human 9.0 pIC50 = 9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21815 89802 2 None - 0 Human 9.0 pIC50 = 9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Br)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
10648551 215206 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL99873 215206 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 484 6 0 4 6.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3cocn3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
24799545 94196 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 439 7 0 4 4.9 CCN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333621 94196 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 439 7 0 4 4.9 CCN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
44407321 81182 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 494 8 3 5 4.5 O=C(O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL202568 81182 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 494 8 3 5 4.5 O=C(O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
44410193 147112 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 511 5 1 6 5.0 Cn1nnc(C2CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
CHEMBL380684 147112 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 511 5 1 6 5.0 Cn1nnc(C2CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
44297605 201466 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00319-9
CHEMBL53312 201466 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00319-9
44456580 162065 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL402895 162065 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 477 4 0 3 5.9 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
24889111 14696 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 656 7 1 4 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090287 14696 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 656 7 1 4 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947645 24015 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 24015 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52948590 24079 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257235 24079 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52943994 24604 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258967 24604 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](N)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10047566 172020 3 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL422931 172020 3 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
44458328 106291 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
CHEMBL283356 106291 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
46227361 209362 0 None 14 4 Human 9.0 pIC50 = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611925 209362 0 None 14 4 Human 9.0 pIC50 = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL389652 219209 0 None -2 4 Rat 9.0 pIC50 = 9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
44335318 11877 0 None - 0 Human 9.0 pIC50 = 9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 603 8 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL105600 11877 0 None - 0 Human 9.0 pIC50 = 9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 603 8 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
44312285 109734 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 703 7 2 4 7.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL306400 109734 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 703 7 2 4 7.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10047566 172020 3 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm0311487
CHEMBL422931 172020 3 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm0311487
71450941 86294 0 None - 0 Human 9.0 pIC50 = 9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 595 5 2 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2113739 86294 0 None - 0 Human 9.0 pIC50 = 9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 595 5 2 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
44305248 209666 0 None - 0 Human 9.0 pIC50 = 9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 585 8 1 3 7.0 CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL62679 209666 0 None - 0 Human 9.0 pIC50 = 9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 585 8 1 3 7.0 CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
9805809 109864 8 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL307488 109864 8 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
2098 10466 36 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
36511 10466 36 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
3805 10466 36 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
3835 10466 36 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
CHEMBL235363 10466 36 None -1 6 Rat 9.0 pIC50 = 9.0 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL None None None None 10.1021/acsmedchemlett.6b00381
CHEMBL5284869 201047 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 533 6 1 6 4.9 CN(C)Cc1[nH]nnc1CN1CCO[C@@]2(CC[C@@H](c3ccccc3C(F)(F)F)CO2)[C@@H]1c1ccc(F)cc1 10.1021/acs.jmedchem.1c00790
10837742 192644 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 462 6 1 4 4.1 NC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
CHEMBL48680 192644 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 462 6 1 4 4.1 NC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
44318685 212781 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 533 6 1 6 4.9 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3C(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL84881 212781 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 533 6 1 6 4.9 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3C(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44408124 82175 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 629 5 0 3 7.2 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
CHEMBL203961 82175 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 629 5 0 3 7.2 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
58993471 128875 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 468 6 1 3 6.2 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596484 128875 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 468 6 1 3 6.2 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1F 10.1016/j.bmcl.2015.04.098
58993453 128879 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 484 6 1 3 6.7 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1Cl 10.1016/j.bmcl.2015.04.098
CHEMBL3596488 128879 0 None - 0 Mongolian jird 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 484 6 1 3 6.7 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1Cl 10.1016/j.bmcl.2015.04.098
56662745 71417 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817889 71417 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817897 71417 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
44415415 85752 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 498 7 1 4 5.8 CN(Cc1nc[nH]n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL211304 85752 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 498 7 1 4 5.8 CN(Cc1nc[nH]n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884469 14765 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 594 6 0 4 7.2 COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL1090651 14765 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 594 6 0 4 7.2 COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
46881779 15222 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 15222 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44306210 109164 0 None - 0 Guinea pig 9.0 pIC50 = 9.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 596 8 2 7 2.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)OCCO2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303896 109164 0 None - 0 Guinea pig 9.0 pIC50 = 9.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 596 8 2 7 2.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)OCCO2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44335372 11546 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 605 7 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
CHEMBL103979 11546 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 605 7 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
10414428 11625 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 523 4 1 4 5.7 Cn1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccc(F)cc2)c2cccnc2c1=O 10.1021/jm00016a014
CHEMBL104301 11625 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 523 4 1 4 5.7 Cn1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccc(F)cc2)c2cccnc2c1=O 10.1021/jm00016a014
44358603 125823 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 633 7 0 3 7.2 CN(CC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL342662 125823 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 633 7 0 3 7.2 CN(CC(c1ccccc1Br)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
9959330 202336 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL554713 202336 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
2098 10466 36 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
36511 10466 36 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3805 10466 36 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
3835 10466 36 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 10466 36 None 1 6 Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None None 10.1021/jm000316h
10578969 64000 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 570 11 1 6 4.8 COc1ccccc1CN(CC(Cc1csc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL165007 64000 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 570 11 1 6 4.8 COc1ccccc1CN(CC(Cc1csc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
10626048 125348 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 530 9 0 3 6.1 CN(C)CCCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL341599 125348 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 530 9 0 3 6.1 CN(C)CCCC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
490428 126354 6 None - 0 Guinea pig 8.9 pIC50 = 8.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346154 126354 6 None - 0 Guinea pig 8.9 pIC50 = 8.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44294535 110288 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 2 7.5 CC1CCN([C@H]2CC[C@](NC(=O)C(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
CHEMBL3085128 110288 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 2 7.5 CC1CCN([C@H]2CC[C@](NC(=O)C(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00250-0
24801458 94199 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 433 6 0 4 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCCC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333624 94199 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 433 6 0 4 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCCC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
44407422 148142 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 571 9 3 7 3.5 CS(=O)(=O)NC(=O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
CHEMBL383743 148142 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 571 9 3 7 3.5 CS(=O)(=O)NC(=O)C1CC2(c3ccc(F)cc3)NC1CCC2NCc1cc(OC(F)(F)F)ccc1OC1CC1 10.1016/j.bmcl.2005.11.026
44410281 82343 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnnn1C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL204573 82343 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 525 5 1 6 5.5 C[C@@H](OC1CCC2NC1(c1ccccc1)CC2c1nnnn1C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
58993670 128880 0 None - 0 Mongolian jird 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 1 3 6.4 Cc1cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)ccc1C#N 10.1016/j.bmcl.2015.04.098
CHEMBL3596489 128880 0 None - 0 Mongolian jird 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 464 6 1 3 6.4 Cc1cc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)ccc1C#N 10.1016/j.bmcl.2015.04.098
57399170 78428 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 458 7 1 5 3.5 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1917842 78428 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 458 7 1 5 3.5 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963612 78428 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 458 7 1 5 3.5 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCN(S(C)(=O)=O)C[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44456650 162273 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL404089 162273 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@@H]1[C@@H](c2ccc(F)cc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
52941570 24016 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256587 24016 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52943848 24192 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257588 24192 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10052312 114167 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 0 3 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL317896 114167 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 0 3 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44338545 16107 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 500 6 1 3 4.2 Brc1cc(I)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL111176 16107 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 500 6 1 3 4.2 Brc1cc(I)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
9916428 119623 2 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 10.1021/jm9700171
CHEMBL330888 119623 2 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 10.1021/jm9700171
10793838 126864 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 611 13 2 7 3.6 COC(=O)CC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL350846 126864 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 611 13 2 7 3.6 COC(=O)CC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
9892852 91155 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL22194 91155 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
9890435 104219 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
CHEMBL27003 104219 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9700171
44333692 11329 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 1 3 7.2 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Nc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102434 11329 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 505 6 1 3 7.2 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Nc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
44270505 19138 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 470 9 2 3 4.1 COc1ccccc1CN[C@H]1C2CC[N+](CC(N)=O)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1185492 19138 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 470 9 2 3 4.1 COc1ccccc1CN[C@H]1C2CC[N+](CC(N)=O)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL417263 19138 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 470 9 2 3 4.1 COc1ccccc1CN[C@H]1C2CC[N+](CC(N)=O)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
9890435 104219 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9506534
CHEMBL27003 104219 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm9506534
9890435 104219 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL27003 104219 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 460 6 1 3 4.9 NC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
44318605 212645 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 425 3 1 4 4.5 COc1ccc(C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL83772 212645 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 425 3 1 4 4.5 COc1ccc(C(F)(F)F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44456894 167317 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL411242 167317 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
10049890 86787 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212839 86787 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
22885690 148561 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 435 4 1 2 6.2 C[C@@H](O[C@H]1CC[C@@H](N)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL386151 148561 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 435 4 1 2 6.2 C[C@@H](O[C@H]1CC[C@@H](N)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
52942803 24018 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256589 24018 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
11756839 11970 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 4 0 3 6.8 Cc1ccccc1-c1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
CHEMBL106087 11970 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 4 0 3 6.8 Cc1ccccc1-c1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
9892852 91155 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm0311487
CHEMBL22194 91155 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm0311487
44358676 36784 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL138890 36784 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
9850771 126656 3 None - 0 Mouse 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL348976 126656 3 None - 0 Mouse 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
9892852 91155 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL22194 91155 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
44368171 52173 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 458 8 1 4 5.2 CN(Cc1nc[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL152742 52173 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 458 8 1 4 5.2 CN(Cc1nc[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10460917 170528 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL420543 170528 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 583 11 2 4 5.5 O=C(CCCN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9871754 12181 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 12181 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
11568372 212804 5 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL85047 212804 5 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL5285318 201071 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 549 7 1 7 4.8 CN(C)Cc1[nH]nnc1CN1CCO[C@@]2(CC[C@@H](c3ccccc3OC(F)(F)F)CO2)[C@@H]1c1ccc(F)cc1 10.1021/acs.jmedchem.1c00790
44318672 212869 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 549 7 1 7 4.8 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3OC(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL85626 212869 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 549 7 1 7 4.8 CN(C)Cc1n[nH]nc1CN1CCOC2(CCC(c3ccccc3OC(F)(F)F)CO2)C1c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
57390401 78382 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 2.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963299 78382 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 2.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL3216988 78382 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 2.9 COc1ccc(-n2nnnc2C(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
44415986 87159 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 527 6 0 4 7.2 C[C@@H](O[C@H]1CC[C@@H](N(C)c2cnccn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
CHEMBL214472 87159 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 527 6 0 4 7.2 C[C@@H](O[C@H]1CC[C@@H](N(C)c2cnccn2)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.044
24889113 14720 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 14720 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 14720 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46881728 12367 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077242 12367 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 628 9 2 6 5.0 C[C@@H](O[C@H]1CN2C(=O)C(NCc3nn[nH]c3CN(C)C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44335319 114287 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 626 8 2 4 5.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
CHEMBL318606 114287 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 626 8 2 4 5.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
44370448 126537 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 717 18 1 5 8.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL347891 126537 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 717 18 1 5 8.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44358604 35294 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 559 7 0 5 5.2 CC(C)N1CCN(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 10.1021/jm000986n
CHEMBL137609 35294 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 559 7 0 5 5.2 CC(C)N1CCN(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 10.1021/jm000986n
44358732 38025 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 587 7 0 3 6.9 Cc1c(F)cccc1C(CN(C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL140124 38025 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 587 7 0 3 6.9 Cc1c(F)cccc1C(CN(C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358428 125787 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 641 7 0 3 7.6 CN(CC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL342607 125787 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 641 7 0 3 7.6 CN(CC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
9871754 12181 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 12181 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
2098 10466 36 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
36511 10466 36 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
3805 10466 36 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
3835 10466 36 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 10466 36 None 1 6 Human 8.9 pIC50 = 8.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None None 10.1021/jm000316h
132837 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
9461 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
CHEMBL22870 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
132837 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
9461 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
CHEMBL22870 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
132837 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
9461 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
CHEMBL22870 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
132837 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
9461 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
CHEMBL22870 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
2098 10466 36 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
36511 10466 36 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
3805 10466 36 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
3835 10466 36 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
CHEMBL235363 10466 36 None -1 6 Rat 8.8 pIC50 = 8.8 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL None None None None 10.1021/jm990197+
136180339 127882 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 406 8 2 5 4.2 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL357303 127882 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 406 8 2 5 4.2 CN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10027219 106358 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 459 6 1 2 6.1 NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL283872 106358 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 459 6 1 2 6.1 NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
44274412 82813 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1ccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)cc1 10.1016/s0960-894x(01)00183-4
CHEMBL20572 82813 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1ccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)cc1 10.1016/s0960-894x(01)00183-4
44410283 145080 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 529 5 1 6 5.0 Cn1nnc(C2(F)CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
CHEMBL377091 145080 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 529 5 1 6 5.0 Cn1nnc(C2(F)CC3(c4ccccc4)NC2CCC3OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2005.12.069
22293475 193907 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL49176 193907 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 620 6 1 2 8.8 CC(NC(=O)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44408295 147103 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.6 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
CHEMBL380651 147103 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 643 5 0 3 7.6 O=C1CN([C@H]2CC[C@](c3ccccc3)(N3CCCC(c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C3=O)CC2)CCN1c1ccccc1 10.1016/j.bmcl.2005.11.111
2098 10466 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
36511 10466 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
3805 10466 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
3835 10466 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
CHEMBL235363 10466 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL None None None None 10.1016/j.bmc.2011.02.031
56662745 71417 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817889 71417 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817897 71417 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 499 6 0 3 6.0 COc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
2098 10466 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
36511 10466 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
3805 10466 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
3835 10466 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
CHEMBL235363 10466 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2008.05.067
44456625 175713 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL438759 175713 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 459 4 0 3 5.8 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN2C(=O)OC[C@H]12)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44415403 145473 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 500 7 2 3 5.4 O=C1CC[C@@H](CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)N1 10.1016/j.bmcl.2006.06.035
CHEMBL377881 145473 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 500 7 2 3 5.4 O=C1CC[C@@H](CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)N1 10.1016/j.bmcl.2006.06.035
52941489 24503 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258623 24503 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52941506 24539 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258732 24539 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46947062 24232 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 24232 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% dog serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
71699792 131563 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 636 5 0 3 7.5 CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3642162 131563 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 636 5 0 3 7.5 CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
19797432 44529 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145800 44529 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10438671 34121 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL136764 34121 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44358707 38231 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL140299 38231 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
9850771 126656 3 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL348976 126656 3 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
10076881 169695 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 577 5 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1 10.1016/s0960-894x(02)00382-7
CHEMBL417407 169695 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 577 5 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1 10.1016/s0960-894x(02)00382-7
10627355 126788 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
CHEMBL350151 126788 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
44338518 14494 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL108889 14494 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
44338359 170208 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL419742 170208 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
132837 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
9461 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
CHEMBL22870 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
132837 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
9461 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
CHEMBL22870 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
132629 9017 15 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/jm034219a
2104 9017 15 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/jm034219a
CHEMBL24999 9017 15 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 508 6 1 2 5.7 Ic1ccccc1CN[C@@H]1C2CCN([C@@H]1C(c1ccccc1)c1ccccc1)CC2 10.1021/jm034219a
132837 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00035a006
9461 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00035a006
CHEMBL22870 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00035a006
21050485 174744 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 3 6.4 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL431732 174744 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 540 5 1 3 6.4 CC(C(=O)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(=O)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
24799366 94193 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 453 8 0 4 5.3 CCN(CC)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333618 94193 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 453 8 0 4 5.3 CCN(CC)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
10648288 108677 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 477 6 0 5 4.8 COC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
CHEMBL300856 108677 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 477 6 0 5 4.8 COC(=O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
24785977 128847 0 None - 0 Mongolian jird 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 426 6 1 3 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccncc2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596456 128847 0 None - 0 Mongolian jird 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 426 6 1 3 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccncc2)c1 10.1016/j.bmcl.2015.04.098
132837 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cellsInhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01029
9461 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cellsInhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01029
CHEMBL22870 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cellsInhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/acs.jmedchem.6b01029
10414293 44227 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145535 44227 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
132837 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/s0960-894x(98)00395-3
9461 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/s0960-894x(98)00395-3
CHEMBL22870 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/s0960-894x(98)00395-3
44396853 74047 9 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0311487
CHEMBL188166 74047 9 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm0311487
21994307 33587 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136305 33587 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358471 36940 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139015 36940 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 585 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2c1OCO2)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
132837 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00066a015
9461 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00066a015
CHEMBL22870 9018 55 None 18 5 Human 8.8 pIC50 = 8.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00066a015
10394703 201746 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 669 9 1 5 6.3 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54540 201746 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 669 9 1 5 6.3 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
135480369 40485 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 514 7 2 5 5.3 Oc1n[nH]c(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)n1 10.1021/jm980376b
CHEMBL142216 40485 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 514 7 2 5 5.3 Oc1n[nH]c(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)n1 10.1021/jm980376b
44274269 83806 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccccn3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL20717 83806 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccccn3)ccc21 10.1016/s0960-894x(01)00182-2
22293476 86403 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 592 7 1 2 8.7 Fc1ccc(C2CCN([C@H]3CC[C@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2115005 86403 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 592 7 1 2 8.7 Fc1ccc(C2CCN([C@H]3CC[C@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
24889283 15203 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 597 6 0 5 7.3 CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1093595 15203 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 597 6 0 5 7.3 CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
52948931 24021 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256592 24021 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 559 5 1 3 6.5 CC[C@@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
52941351 24150 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257466 24150 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 531 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@H](O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
44306310 109097 0 None - 0 Guinea pig 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 588 8 2 5 4.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303548 109097 0 None - 0 Guinea pig 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 588 8 2 5 4.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44306023 109163 0 None - 0 Guinea pig 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 577 8 3 5 3.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303890 109163 0 None - 0 Guinea pig 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 577 8 3 5 3.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
10100236 35587 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL137887 35587 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 607 7 0 3 7.2 CN(CC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44358470 36701 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 593 7 1 3 6.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138825 36701 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 593 7 1 3 6.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)cc1Cl)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358561 37249 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 627 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139286 37249 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 627 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(C(F)(F)F)c1F)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
2098 10466 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
36511 10466 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
3805 10466 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
3835 10466 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
CHEMBL235363 10466 36 None 1 6 Human 8.8 pIC50 = 8.8 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None None 10.1021/jm000316h
10075595 67121 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 527 10 2 3 5.4 CN(C)CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL174526 67121 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 527 10 2 3 5.4 CN(C)CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
10554361 37634 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1cccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL139719 37634 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1cccnc1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
10529338 38191 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 498 7 1 4 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3nc[nH]n3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL140263 38191 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 498 7 1 4 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3nc[nH]n3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
10840066 123498 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccccn1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL337358 123498 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 536 7 0 3 6.4 O=C(Cc1ccccn1)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
71541574 94186 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 394 7 0 3 5.2 CN1CCC(COCc2cc(C3CC3)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333611 94186 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 394 7 0 3 5.2 CN1CCC(COCc2cc(C3CC3)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
44307181 210497 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.3 NC(=O)CCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL67667 210497 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.3 NC(=O)CCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
58993542 128886 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 490 7 0 3 7.0 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(C4CC4)CC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596495 128886 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 490 7 0 3 7.0 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(C4CC4)CC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
46884432 14694 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 588 5 0 3 7.7 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090285 14694 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 588 5 0 3 7.7 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947647 24019 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256590 24019 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@H](NCc4ccccc4)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24752718 13315 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 13315 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24750734 14785 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090742 14785 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)CC(N)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
44306218 169353 0 None - 0 Guinea pig 8.7 pIC50 = 8.7 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 554 8 3 6 2.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL416864 169353 0 None - 0 Guinea pig 8.7 pIC50 = 8.7 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 554 8 3 6 2.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44370973 53539 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 726 20 2 6 6.3 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL153976 53539 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 726 20 2 6 6.3 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44370354 127994 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 774 19 2 6 7.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)C(=O)OCc2ccccc2)C1 10.1016/0960-894X(95)00080-D
CHEMBL357757 127994 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 774 19 2 6 7.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)C(=O)OCc2ccccc2)C1 10.1016/0960-894X(95)00080-D
10462250 128171 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 683 18 1 5 7.5 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL358173 128171 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 683 18 1 5 7.5 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44358720 35273 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 0 3 6.8 CN(CC(c1ccc(F)c(F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL137580 35273 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 0 3 6.8 CN(CC(c1ccc(F)c(F)c1F)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44358657 37177 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL139226 37177 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
10816935 124885 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.2 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL340732 124885 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.2 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
46881821 12372 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1077281 12372 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 570 7 2 4 5.6 C[C@@H](O[C@H]1CN2C(=O)CC(NCc3ccn[nH]3)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
71541373 94200 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 463 6 0 4 5.0 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC4CC43)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333625 94200 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 463 6 0 4 5.0 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC4CC43)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
24800231 94212 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.3 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333637 94212 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.3 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
24785712 128882 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 451 6 1 4 5.5 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2015.04.098
CHEMBL3596491 128882 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 451 6 1 4 5.5 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2015.04.098
57393953 78390 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 460 7 1 7 3.7 CCN1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917849 78390 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 460 7 1 7 3.7 CCN1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963369 78390 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 460 7 1 7 3.7 CCN1CC[C@H](NCc2cc(-n3nnnc3C(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
44415443 84710 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 431 6 1 2 6.0 CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL209531 84710 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 431 6 1 2 6.0 CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415485 86685 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 8 2 3 4.9 NC(=O)CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212439 86685 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 8 2 3 4.9 NC(=O)CNC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415502 86812 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 488 8 1 3 5.2 CN(CC(N)=O)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212919 86812 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 488 8 1 3 5.2 CN(CC(N)=O)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884517 14864 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 643 7 0 4 8.0 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1091341 14864 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 643 7 0 4 8.0 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
24768572 14541 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089270 14541 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 624 5 0 3 8.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCN(C(C)(C)C)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947645 24015 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256586 24015 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 596 5 0 4 6.1 C[C@@H](O[C@H]1CN2C(=O)C3CN(C4=CC(=O)CC4)CC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
46947062 24232 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1257706 24232 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% mongolian gerbil serum
ChEMBL 545 4 1 3 6.1 C[C@@H](O[C@H]1CN2C(=O)[C@H]3C[C@@](C)(O)C[C@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
24752718 13315 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1082896 13315 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 542 5 0 5 5.5 C[C@@H](O[C@H]1CN2C(=O)C(n3cnnc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
19797432 44529 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145800 44529 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 427 7 0 3 5.8 COc1cc(C)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10650469 64213 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 557 10 2 4 4.7 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165498 64213 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 557 10 2 4 4.7 CC(=O)N(Cc1ccccc1Cl)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44328374 214766 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 5.9 COc1ccccc1CNC1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL97241 214766 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 5.9 COc1ccccc1CNC1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
11755361 123346 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)cc1F)c1ccccc1 10.1021/jm00022a010
CHEMBL336439 123346 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)cc1F)c1ccccc1 10.1021/jm00022a010
15639149 119686 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 452 7 1 3 5.9 COc1ccccc1CN[C@H]1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL331059 119686 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 452 7 1 3 5.9 COc1ccccc1CN[C@H]1C2CC3CCCC2CN3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
10413173 36431 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 487 8 3 3 5.7 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c(F)c1 10.1021/jm00022a010
CHEMBL138620 36431 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 487 8 3 3 5.7 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c(F)c1 10.1021/jm00022a010
44346149 22289 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 518 6 1 2 7.1 FC(F)(F)c1cc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL121742 22289 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 518 6 1 2 7.1 FC(F)(F)c1cc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44346551 22354 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 481 8 0 2 7.0 CN(C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL122119 22354 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 481 8 0 2 7.0 CN(C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
10359664 120779 0 None - 1 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 336 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 10.1021/jm9700171
CHEMBL332644 120779 0 None - 1 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 336 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 10.1021/jm9700171
54581461 68037 0 None -6 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
CHEMBL1766207 68037 0 None -6 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
10254526 107272 0 None - 0 Human 8.0 pIC50 = 8 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 7 0 1 6.9 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL291025 107272 0 None - 0 Human 8.0 pIC50 = 8 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 7 0 1 6.9 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44368083 51733 0 None - 0 Human 8.0 pIC50 = 8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 6 4.3 Cn1nnnc1CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL152339 51733 0 None - 0 Human 8.0 pIC50 = 8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 6 4.3 Cn1nnnc1CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
10457416 21658 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL120781 21658 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
10098987 66755 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173396 66755 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 547 9 2 3 6.1 O=C(Cc1ccncc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
14986135 170180 0 None - 0 Guinea pig 8.0 pIC50 = 8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL419500 170180 0 None - 0 Guinea pig 8.0 pIC50 = 8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44402934 77847 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity towards tachykinin receptor 1Binding affinity towards tachykinin receptor 1
ChEMBL 589 9 1 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1 10.1021/jm058225d
CHEMBL195222 77847 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity towards tachykinin receptor 1Binding affinity towards tachykinin receptor 1
ChEMBL 589 9 1 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1 10.1021/jm058225d
44359091 38022 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 505 8 3 3 6.4 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc2ccccc2c1)c1ccccc1 10.1021/jm00022a010
CHEMBL140123 38022 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 505 8 3 3 6.4 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc2ccccc2c1)c1ccccc1 10.1021/jm00022a010
44346420 21077 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Compound was evaluated for its affinity to rat Tachykinin receptor 1Compound was evaluated for its affinity to rat Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
CHEMBL119990 21077 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Compound was evaluated for its affinity to rat Tachykinin receptor 1Compound was evaluated for its affinity to rat Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
44318657 212698 0 None - 0 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 375 3 1 4 3.6 COc1ccc(F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL84090 212698 0 None - 0 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 375 3 1 4 3.6 COc1ccc(F)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL2371978 216951 0 None 30 3 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
104943 62160 39 None 1862 3 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL16192 62160 39 None 1862 3 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00287-9
18391045 107172 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 487 6 2 3 4.0 NC(=O)CN[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL290043 107172 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 487 6 2 3 4.0 NC(=O)CN[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
44288896 175766 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL43912 175766 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
19098237 43895 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145265 43895 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
44312056 211502 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 595 7 2 4 6.2 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL74237 211502 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 595 7 2 4 6.2 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
44358585 38040 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 615 9 0 5 6.4 COc1cccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC 10.1021/jm000986n
CHEMBL140134 38040 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 615 9 0 5 6.4 COc1cccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC 10.1021/jm000986n
18709652 175065 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 2 5 4.3 COc1ccc(OCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
CHEMBL434012 175065 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 2 5 4.3 COc1ccc(OCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
44306230 107532 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 594 8 2 6 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1csc2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL292799 107532 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 594 8 2 6 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1csc2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44319057 212623 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL83585 212623 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
19049350 106056 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL281940 106056 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
19049350 106056 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL281940 106056 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
19049350 106056 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
CHEMBL281940 106056 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 453 7 1 2 6.4 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
44346694 121588 1 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 453 7 1 2 6.4 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL334072 121588 1 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 453 7 1 2 6.4 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44289443 175851 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 502 11 2 5 4.4 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CSc1ccccn1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL43970 175851 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 502 11 2 5 4.4 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CSc1ccccn1)C(C)=O 10.1016/s0960-894x(01)00250-5
44297749 201241 0 None - 0 Human 7.0 pIC50 = 7 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL52892 201241 0 None - 0 Human 7.0 pIC50 = 7 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44333579 11154 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 506 7 2 4 5.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(N)=O)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL101288 11154 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 506 7 2 4 5.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(N)=O)cc2)c1 10.1016/S0960-894X(96)00563-X
44338510 15405 0 None - 1 Human 7.0 pIC50 = 7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 450 6 1 3 5.0 Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00563-2
CHEMBL109514 15405 0 None - 1 Human 7.0 pIC50 = 7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 450 6 1 3 5.0 Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00563-2
44338531 16130 0 None - 1 Human 7.0 pIC50 = 7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 408 6 1 3 5.4 CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 10.1016/s0960-894x(02)00563-2
CHEMBL111304 16130 0 None - 1 Human 7.0 pIC50 = 7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 408 6 1 3 5.4 CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 10.1016/s0960-894x(02)00563-2
44322648 213097 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 386 6 1 3 4.1 Cc1cc(C)cc(OCC(=O)N(Cc2cccc(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL87194 213097 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 386 6 1 3 4.1 Cc1cc(C)cc(OCC(=O)N(Cc2cccc(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
44322525 213352 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 492 6 1 2 6.1 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL88810 213352 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 492 6 1 2 6.1 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 10.1016/s0960-894x(01)00727-2
10095174 213442 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 446 5 1 3 5.5 O=C(COc1cc(Cl)cc(Cl)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89385 213442 0 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 446 5 1 3 5.5 O=C(COc1cc(Cl)cc(Cl)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44415470 172623 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL424883 172623 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884433 14695 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 581 5 0 2 7.9 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090286 14695 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 581 5 0 2 7.9 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44294395 193974 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(CCO)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
74972677 193974 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(CCO)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL49233 193974 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(CCO)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
15755315 169960 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 731 16 4 9 4.0 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccc(Cl)cc1 10.1021/jm00089a011
CHEMBL418124 169960 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 731 16 4 9 4.0 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccc(Cl)cc1 10.1021/jm00089a011
15755303 207127 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 596 15 4 7 3.1 CC(C)C[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL59768 207127 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 596 15 4 7 3.1 CC(C)C[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
15755300 209756 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 630 15 4 7 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL63059 209756 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 630 15 4 7 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44337428 14007 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Br 10.1021/jm970499g
CHEMBL108575 14007 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Br 10.1021/jm970499g
10793341 115617 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc([N+](=O)[O-])cc1 10.1021/jm970499g
CHEMBL320989 115617 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc([N+](=O)[O-])cc1 10.1021/jm970499g
44411742 85078 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of human NK1 receptor expressed in U373MG cellsInhibition of human NK1 receptor expressed in U373MG cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1 10.1016/j.bmcl.2006.02.027
CHEMBL210811 85078 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of human NK1 receptor expressed in U373MG cellsInhibition of human NK1 receptor expressed in U373MG cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1 10.1016/j.bmcl.2006.02.027
44344435 19858 0 None - 0 Human 6.0 pIC50 = 6 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 473 5 1 3 6.1 Cc1cc(C)cc(C(=O)N2C3C=C(c4ccccc4)C2CC(NCc2ccnc4ccccc24)C3)c1 10.1016/S0960-894X(96)00623-3
CHEMBL119025 19858 0 None - 0 Human 6.0 pIC50 = 6 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 473 5 1 3 6.1 Cc1cc(C)cc(C(=O)N2C3C=C(c4ccccc4)C2CC(NCc2ccnc4ccccc24)C3)c1 10.1016/S0960-894X(96)00623-3
2125 9804 2 None - 1 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
5311350 9804 2 None - 1 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
CHEMBL444832 9804 2 None - 1 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
44291515 107915 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 580 17 4 5 4.6 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O 10.1016/S0960-894X(00)80360-1
CHEMBL295301 107915 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 580 17 4 5 4.6 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O 10.1016/S0960-894X(00)80360-1
44291788 108189 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO 10.1016/S0960-894X(00)80360-1
CHEMBL297327 108189 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligandBinding affinity for NK1 receptor binding sites in human lymphoma IM9 cells by using [125I]-Bolton-Hunter substance P as radioligand
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO 10.1016/S0960-894X(00)80360-1
44346650 121216 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)N1 10.1021/jm9700171
CHEMBL333308 121216 0 None - 0 Human 5.0 pIC50 = 5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 322 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)N1 10.1021/jm9700171
15755305 107762 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 663 16 4 9 3.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL294288 107762 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 663 16 4 9 3.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)OCc1ccccc1 10.1021/jm00089a011
15755312 107837 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 621 14 4 9 1.8 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C 10.1021/jm00089a011
CHEMBL294737 107837 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 621 14 4 9 1.8 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C 10.1021/jm00089a011
15755330 209596 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
CHEMBL62349 209596 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
15755295 210046 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 595 15 4 8 1.0 NC(=O)CC[C@H](NC(=O)[C@H]1CCCN1C(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64631 210046 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 595 15 4 8 1.0 NC(=O)CC[C@H](NC(=O)[C@H]1CCCN1C(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL1190873 215372 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00089a011
CHEMBL541800 215372 0 None - 0 Guinea pig 5.0 pIC50 = 5 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00089a011
10840399 16147 0 None - 0 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 549 9 2 4 4.4 CN(Cc1ccncc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL111384 16147 0 None - 0 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 549 9 2 4 4.4 CN(Cc1ccncc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
15755333 107353 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 593 16 7 7 -0.0 NC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00089a011
CHEMBL291602 107353 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 593 16 7 7 -0.0 NC(=O)CC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/jm00089a011
15755331 107625 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
CHEMBL293445 107625 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 761 16 5 6 6.7 O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)OCc1ccccc1 10.1021/jm00089a011
15755294 210093 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 561 13 4 8 0.6 CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64829 210093 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 561 13 4 8 0.6 CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64601 222634 0 None - 0 Guinea pig 4.0 pIC50 = 4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00089a011
10744888 115444 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.0 CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)c1ccccc1 10.1021/jm970499g
CHEMBL320762 115444 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.0 CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)c1ccccc1 10.1021/jm970499g
44337578 174866 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 545 9 2 5 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL432620 174866 0 None - 0 Human 4.0 pIC50 = 4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 545 9 2 5 4.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] 10.1021/jm970499g
15485361 104005 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 576 9 0 3 7.5 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
CHEMBL26860 104005 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 576 9 0 3 7.5 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
10362340 97045 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23851 97045 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44274545 89286 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 561 8 0 4 7.3 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CC3CC3)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21775 89286 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 561 8 0 4 7.3 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(CC3CC3)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
44362598 43598 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(COC2C3CCN(CC3)C2Cc2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145022 43598 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(COC2C3CCN(CC3)C2Cc2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
10362340 97045 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1016/s0960-894x(98)00395-3
CHEMBL23851 97045 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 379 6 3 3 3.4 CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1016/s0960-894x(98)00395-3
44312026 109628 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 439 7 2 2 4.8 Cc1cc(C)cc(CN(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL305608 109628 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 439 7 2 2 4.8 Cc1cc(C)cc(CN(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
44289232 176651 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1ccccc1Cl)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL444043 176651 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1ccccc1Cl)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10349900 113526 0 None - 3 Rat 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 113526 0 None - 3 Rat 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL2369600 216413 0 None - 1 Human 6.0 pIC50 = 6.0 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
10477952 105764 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(Cl)c1)c1ccccc1 10.1021/jm00035a006
CHEMBL279916 105764 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(Cl)c1)c1ccccc1 10.1021/jm00035a006
19797474 44245 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 419 6 0 2 5.8 Fc1ccc(F)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145552 44245 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 419 6 0 2 5.8 Fc1ccc(F)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44384902 66721 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL173245 66721 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
44362586 44525 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(COC2C3CCN(CC3)C2Cc2ccccc2)c1 10.1021/jm00024a007
CHEMBL145799 44525 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(COC2C3CCN(CC3)C2Cc2ccccc2)c1 10.1021/jm00024a007
44276673 104132 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 604 7 1 4 6.6 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL26951 104132 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 604 7 1 4 6.6 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
44324705 119134 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 804 16 0 4 9.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/S0960-894X(01)80747-2
CHEMBL329445 119134 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 804 16 0 4 9.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/S0960-894X(01)80747-2
44359056 126228 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 513 9 3 5 5.1 COC(=O)c1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
CHEMBL345069 126228 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 513 9 3 5 5.1 COC(=O)c1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
10039383 92252 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm9700171
CHEMBL22680 92252 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm9700171
44297603 169907 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL417760 169907 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
11683136 112580 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126963 112580 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
44333708 170155 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 6.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(F)(F)F)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL419352 170155 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 6.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C(F)(F)F)cc2)c1 10.1016/S0960-894X(96)00563-X
11489471 101655 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 532 6 0 3 7.4 COCc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL25398 101655 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 532 6 0 3 7.4 COCc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
10389968 66667 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 470 4 1 3 5.7 CC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
CHEMBL173014 66667 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 470 4 1 3 5.7 CC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
21753663 203434 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 4.8 Cc1cc(C)cc(COCC(NC=O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL56442 203434 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 4.8 Cc1cc(C)cc(COCC(NC=O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
71541576 94188 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 6 0 3 5.8 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333613 94188 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 6 0 3 5.8 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2012.11.094
24800927 94214 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 384 5 1 3 4.6 FC(F)(F)c1cc(Cl)nc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333639 94214 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 384 5 1 3 4.6 FC(F)(F)c1cc(Cl)nc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
44433783 96964 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 0 3 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL238209 96964 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 0 3 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)OC(C)(C)C)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
46883823 15204 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093596 15204 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 586 5 1 4 6.0 C[C@@H](O[C@H]1CN2C(=O)C=C(N3CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
11705241 95010 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 459 6 0 2 6.7 CCN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347857 95010 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 459 6 0 2 6.7 CCN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
24993314 177818 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
CHEMBL445686 177818 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 569 5 0 3 8.1 CC1=C(N2C[C@H]3CC[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3C2)CCC1=O 10.1021/jm8016514
44306115 210268 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 498 10 4 4 2.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CO)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL66151 210268 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 498 10 4 4 2.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CO)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44324814 213984 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 606 16 1 4 6.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC)CC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL92621 213984 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 606 16 1 4 6.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(CC)CC)C1 10.1016/S0960-894X(01)80747-2
44288901 170061 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 559 8 1 4 5.6 CN(C)CCCOC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL418697 170061 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 559 8 1 4 5.6 CN(C)CCCOC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
11318556 100710 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding componentInhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding component
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL24829 100710 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding componentInhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding component
ChEMBL 531 6 1 3 6.9 CN(C)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
10840688 126979 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 564 11 1 5 4.7 COc1ccccc1CN(CC(Cc1ccc2ccccc2c1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351940 126979 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 564 11 1 5 4.7 COc1ccccc1CN(CC(Cc1ccc2ccccc2c1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44299464 206544 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 385 7 1 2 5.7 NC(COCc1cc(Cl)cc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL59380 206544 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 385 7 1 2 5.7 NC(COCc1cc(Cl)cc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44306211 109113 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 592 8 2 5 4.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)CCCC2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL303680 109113 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 592 8 2 5 4.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2c(c1)CCCC2)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
46884467 14763 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090649 14763 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccnc(F)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10202046 127839 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL356912 127839 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
10407571 174736 10 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80246-2
CHEMBL431690 174736 10 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80246-2
44307162 210139 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 493 6 0 2 7.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccccc3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
CHEMBL65153 210139 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 493 6 0 2 7.6 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccccc3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00009-I
71583096 94995 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmc.2013.02.010
CHEMBL2347694 94995 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmc.2013.02.010
15755296 109060 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 670 14 4 9 3.5 C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL303337 109060 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 670 14 4 9 3.5 C[C@@H](O)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
15755297 109436 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 656 14 4 9 3.1 CC(C)(C)OC(=O)N[C@@H](CO)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL304472 109436 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 656 14 4 9 3.1 CC(C)(C)OC(=O)N[C@@H](CO)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
10256518 104170 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 5 0 3 6.4 CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00016a014
CHEMBL269781 104170 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 5 0 3 6.4 CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00016a014
10363425 171387 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 397 4 1 3 4.9 CN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL421591 171387 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 397 4 1 3 4.9 CN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44288846 175115 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 485 6 1 3 6.4 O=C(c1cccc2ccccc12)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL43432 175115 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 485 6 1 3 6.4 O=C(c1cccc2ccccc12)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10317821 43563 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 383 6 0 2 5.5 c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL144996 43563 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 383 6 0 2 5.5 c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44358472 123573 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 601 9 1 5 6.1 COc1ccc(OC)c(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL337803 123573 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 601 9 1 5 6.1 COc1ccc(OC)c(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
44294321 18822 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
54093758 18822 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
CHEMBL1183502 18822 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
CHEMBL301168 18822 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 492 4 0 4 6.5 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3cc(Cl)c(Cl)cc3nc21 10.1021/jm00109a034
15037921 126403 0 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 444 8 1 2 6.2 Clc1ccccc1CCCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346626 126403 0 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 444 8 1 2 6.2 Clc1ccccc1CCCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
68928842 131576 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 1 5 4.1 CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642175 131576 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 1 5 4.1 CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
44312218 210919 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 542 8 1 4 5.5 CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL70461 210919 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 542 8 1 4 5.5 CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10506929 63353 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 10.1021/jm950616c
CHEMBL164175 63353 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 10.1021/jm950616c
44328416 214720 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 476 6 1 2 6.6 FC(F)(F)c1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL96956 214720 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 476 6 1 2 6.6 FC(F)(F)c1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
10039383 92252 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm980376b
CHEMBL22680 92252 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 281 5 1 2 3.5 c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm980376b
19797452 128307 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 413 7 0 3 5.5 COc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL358529 128307 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 413 7 0 3 5.5 COc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44287503 106982 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 7 1 1 6.6 O=C(CC(c1ccccc1)c1ccccc1)NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL288340 106982 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 7 1 1 6.6 O=C(CC(c1ccccc1)c1ccccc1)NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
44299829 205855 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 403 4 1 2 5.4 FC(F)(F)c1cc(CC[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
CHEMBL58774 205855 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 403 4 1 2 5.4 FC(F)(F)c1cc(CC[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
44287541 166436 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.6 CN(CC(c1ccccc1)c1ccccc1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL41038 166436 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.6 CN(CC(c1ccccc1)c1ccccc1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL449091 220739 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
10692651 107866 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL294960 107866 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
19003165 108951 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COCC(N)Cc2cccc3ccccc23)c1 10.1016/S0960-894X(00)80063-3
CHEMBL302719 108951 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COCC(N)Cc2cccc3ccccc23)c1 10.1016/S0960-894X(00)80063-3
3198 212292 76 None -37 34 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 212292 76 None -37 34 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 212292 76 None -37 34 Human 4.9 pIC50 = 4.9 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
44297683 174969 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL433285 174969 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
9869033 107200 5 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL290364 107200 5 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00563-X
71541468 94208 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 424 6 0 3 5.5 CC(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333633 94208 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 424 6 0 3 5.5 CC(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
24801626 94215 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 398 5 0 3 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333640 94215 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 398 5 0 3 4.9 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
57403990 77729 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 543 6 1 3 4.5 CC(=O)NCC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951620 77729 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 543 6 1 3 4.5 CC(=O)NCC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
44335410 11772 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 574 7 1 2 7.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL105009 11772 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 574 7 1 2 7.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
44288885 107060 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 500 8 1 4 4.9 COc1cc(CC(=O)N[C@H]2CCN(C(=O)c3cc(C)cc(C)c3)[C@H](Cc3ccccc3)C2)cc(OC)c1 10.1016/0960-894X(96)00287-9
CHEMBL289026 107060 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 500 8 1 4 4.9 COc1cc(CC(=O)N[C@H]2CCN(C(=O)c3cc(C)cc(C)c3)[C@H](Cc3ccccc3)C2)cc(OC)c1 10.1016/0960-894X(96)00287-9
44396809 173146 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 462 6 1 2 6.5 Cc1cc(C)cc(C(=O)N2CCC(NCc3cccc4ccccc34)CC2Cc2ccccc2)c1 10.1021/jm0311487
CHEMBL427514 173146 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 462 6 1 2 6.5 Cc1cc(C)cc(C(=O)N2CCC(NCc3cccc4ccccc34)CC2Cc2ccccc2)c1 10.1021/jm0311487
44358709 36563 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 645 10 0 6 6.4 COc1ccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC 10.1021/jm000986n
CHEMBL138715 36563 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 645 10 0 6 6.4 COc1ccc(C(CN(C)C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC 10.1021/jm000986n
44358679 36629 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 611 6 0 4 7.4 COc1ccccc1C(C1CCCCN1C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138770 36629 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 611 6 0 4 7.4 COc1ccccc1C(C1CCCCN1C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358680 123382 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 608 8 1 3 6.8 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(Cc1c[nH]c2ccccc12)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL336715 123382 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 608 8 1 3 6.8 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(Cc1c[nH]c2ccccc12)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
44358683 126148 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 497 7 0 5 4.8 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Cl 10.1021/jm000986n
CHEMBL344434 126148 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 497 7 0 5 4.8 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Cl 10.1021/jm000986n
9869033 107200 5 None - 0 Human 7.9 pIC50 = 7.9 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL290364 107200 5 None - 0 Human 7.9 pIC50 = 7.9 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
9869033 107200 5 None - 0 Human 7.9 pIC50 = 7.9 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00623-3
CHEMBL290364 107200 5 None - 0 Human 7.9 pIC50 = 7.9 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00623-3
9910357 18751 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 427 7 1 2 5.2 COc1ccccc1CN[C@H]1C2CC[N+](C)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1183052 18751 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 427 7 1 2 5.2 COc1ccccc1CN[C@H]1C2CC[N+](C)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL277524 18751 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 427 7 1 2 5.2 COc1ccccc1CN[C@H]1C2CC[N+](C)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
44338638 12496 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL107829 12496 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44338546 115385 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 382 6 1 3 4.0 Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL320535 115385 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 382 6 1 3 4.0 Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
9917079 67939 39 None - 0 Mongolian jird 7.9 pIC50 = 7.9 Binding
Binding affinity to gerbil NK1 receptorBinding affinity to gerbil NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
CHEMBL1765508 67939 39 None - 0 Mongolian jird 7.9 pIC50 = 7.9 Binding
Binding affinity to gerbil NK1 receptorBinding affinity to gerbil NK1 receptor
ChEMBL 619 5 1 3 7.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccc(Cl)cc2)C1)c1ccnc2ccccc12 10.1016/j.bmc.2011.02.031
44346334 22017 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.0 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL121094 22017 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.0 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
10837362 37523 1 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 416 5 2 2 5.1 FC(F)(F)c1cc(CNCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL139558 37523 1 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 416 5 2 2 5.1 FC(F)(F)c1cc(CNCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
44299969 203975 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 5.6 CCNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL56814 203975 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 9 1 2 5.6 CCNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44359117 126111 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 525 9 3 5 6.0 COc1cccc2cc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)oc12 10.1021/jm00022a010
CHEMBL344217 126111 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 525 9 3 5 6.0 COc1cccc2cc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)oc12 10.1021/jm00022a010
44297491 202129 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 578 10 1 7 3.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc([N+](=O)[O-])c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL55180 202129 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 578 10 1 7 3.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc([N+](=O)[O-])c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
76325557 112576 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 514 6 0 3 6.4 CN1CCN(C2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126959 112576 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 514 6 0 3 6.4 CN1CCN(C2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)CC1 10.1016/j.bmcl.2014.01.036
76325558 112585 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 485 6 0 2 7.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126968 112585 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 485 6 0 2 7.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
490428 126354 6 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346154 126354 6 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
22293473 86407 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.8 O=C(OC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL2115009 86407 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.8 O=C(OC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
24783682 128850 0 None - 0 Mongolian jird 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 475 6 1 2 7.4 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3ccccc3c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596459 128850 0 None - 0 Mongolian jird 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 475 6 1 2 7.4 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3ccccc3c2)c1 10.1016/j.bmcl.2015.04.098
11724403 175324 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1021/jm00024a007
CHEMBL435564 175324 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1021/jm00024a007
9852911 106159 0 None 8 6 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against Tachykinin receptor 1Tested for binding affinity against Tachykinin receptor 1
ChEMBL 678 20 2 7 7.4 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm000316h
CHEMBL282618 106159 0 None 8 6 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against Tachykinin receptor 1Tested for binding affinity against Tachykinin receptor 1
ChEMBL 678 20 2 7 7.4 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm000316h
CHEMBL2372525 217049 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
CHEMBL5268296 200337 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomesInhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomes
ChEMBL 1264 38 15 16 -2.1 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)O 10.1021/acs.jmedchem.6b01029
15118534 112967 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 467 0 1 5 4.6 C#C[C@]1(O)CC[C@H]2[C@@H]3CC[C@H]4Cc5nc6nc7ccccc7c(=O)n6cc5C[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm00080a025
CHEMBL3138259 112967 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 467 0 1 5 4.6 C#C[C@]1(O)CC[C@H]2[C@@H]3CC[C@H]4Cc5nc6nc7ccccc7c(=O)n6cc5C[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm00080a025
11445389 195170 15 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibition of substance P receptorInhibition of substance P receptor
ChEMBL 692 5 2 6 3.7 CN1C(=O)[C@@H]2C[C@@]3([C@@]45C[C@H]6C(=O)N(C)[C@@H](Cc7ccccc7)C(=O)N6[C@@H]4Nc4ccccc45)c4ccccc4N[C@H]3N2C(=O)[C@@H]1Cc1ccccc1 10.1021/np50111a008
CHEMBL501675 195170 15 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibition of substance P receptorInhibition of substance P receptor
ChEMBL 692 5 2 6 3.7 CN1C(=O)[C@@H]2C[C@@]3([C@@]45C[C@H]6C(=O)N(C)[C@@H](Cc7ccccc7)C(=O)N6[C@@H]4Nc4ccccc45)c4ccccc4N[C@H]3N2C(=O)[C@@H]1Cc1ccccc1 10.1021/np50111a008
44287211 167314 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.9 CN(C(=O)CC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL41124 167314 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.9 CN(C(=O)CC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
16755229 180706 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 513 4 1 3 7.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2ccnc12 10.1016/j.bmc.2008.05.067
CHEMBL454087 180706 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 513 4 1 3 7.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2ccnc12 10.1016/j.bmc.2008.05.067
10435750 106032 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 365 6 1 2 4.1 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 10.1021/jm00035a006
CHEMBL281804 106032 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 365 6 1 2 4.1 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 10.1021/jm00035a006
10506124 108037 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL296228 108037 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
10435750 106032 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 365 6 1 2 4.1 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 10.1021/jm00066a015
CHEMBL281804 106032 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 365 6 1 2 4.1 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)[N+](C)(C)C)c1 10.1021/jm00066a015
44312952 112172 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 668 16 6 6 2.4 CC(=O)NC(C(=O)NCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
CHEMBL311688 112172 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 668 16 6 6 2.4 CC(=O)NC(C(=O)NCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
44322649 170150 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 494 6 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL419312 170150 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 494 6 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1Cl)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44322524 213381 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 462 7 1 2 6.1 Fc1ccc(CN(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 10.1016/s0960-894x(01)00727-2
CHEMBL88998 213381 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 462 7 1 2 6.1 Fc1ccc(CN(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 10.1016/s0960-894x(01)00727-2
44322704 213501 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 426 6 1 3 4.8 O=C(COc1cc(Cl)cc(Cl)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89847 213501 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 426 6 1 3 4.8 O=C(COc1cc(Cl)cc(Cl)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44346399 168448 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 536 9 3 3 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL413108 168448 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 536 9 3 3 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
44322678 213340 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 414 5 1 3 4.4 O=C(COc1cc(F)cc(F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL88731 213340 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 414 5 1 3 4.4 O=C(COc1cc(F)cc(F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44346333 19828 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 10 3 3 6.5 CN(Cc1ccccc1)C[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL1190061 19828 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 10 3 3 6.5 CN(Cc1ccccc1)C[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL540060 19828 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 10 3 3 6.5 CN(Cc1ccccc1)C[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
10530444 126978 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 537 11 2 4 4.1 CC(=O)N(CCc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL351922 126978 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 537 11 2 4 4.1 CC(=O)N(CCc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44212284 66762 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c(OC)c1 10.1016/0960-894X(96)00148-5
CHEMBL173420 66762 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c(OC)c1 10.1016/0960-894X(96)00148-5
19797443 172390 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL424307 172390 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10439730 113534 0 None 39 3 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 113534 0 None 39 3 Human 6.9 pIC50 = 6.9 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44346302 119878 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(CO[C@@H]2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1021/jm9700171
CHEMBL331392 119878 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(CO[C@@H]2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1021/jm9700171
11724403 175324 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL435564 175324 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
44333821 11548 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 457 5 0 3 5.6 CC(C)N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
CHEMBL103984 11548 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 457 5 0 3 5.6 CC(C)N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00616-3
44297293 177607 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 617 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CSCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL445357 177607 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 617 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CSCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44368118 126262 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 473 8 0 6 4.6 CN(Cc1nnnn1C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL345315 126262 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 473 8 0 6 4.6 CN(Cc1nnnn1C)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
22859115 214010 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 363 5 1 2 4.9 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL92818 214010 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 363 5 1 2 4.9 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
44334143 11346 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 497 6 1 3 6.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL102569 11346 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 497 6 1 3 6.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2)c1 10.1016/S0960-894X(96)00563-X
22859115 214010 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 363 5 1 2 4.9 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL92818 214010 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 363 5 1 2 4.9 N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
2090 9543 25 None - 4 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
5311312 9543 25 None - 4 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL437797 9543 25 None - 4 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
24801795 94204 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 490 6 0 5 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333629 94204 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 490 6 0 5 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
44318405 112358 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 357 3 1 4 3.4 COc1ccccc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL312202 112358 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 357 3 1 4 3.4 COc1ccccc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
24784192 128862 0 None - 0 Mongolian jird 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 441 6 2 3 5.9 Oc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596471 128862 0 None - 0 Mongolian jird 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 441 6 2 3 5.9 Oc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44297912 201467 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 527 10 1 5 5.0 COc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL53314 201467 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 527 10 1 5 5.0 COc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
44433786 153688 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 4 0 2 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)N2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL392567 153688 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 4 0 2 6.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)N2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
46883824 15205 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 5 1 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1093597 15205 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 5 1 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCC(O)CC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52941570 24016 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256587 24016 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52941550 24576 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258852 24576 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
10251123 11610 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 6 1 4 5.1 COc1ccccc1CNCc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104225 11610 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 6 1 4 5.1 COc1ccccc1CNCc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
44370893 126621 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 606 17 3 5 4.4 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCC(N)=O)C1 10.1016/0960-894X(95)00080-D
CHEMBL348594 126621 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 606 17 3 5 4.4 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCC(N)=O)C1 10.1016/0960-894X(95)00080-D
9869033 107200 5 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL290364 107200 5 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
71449177 86437 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 682 17 6 6 2.8 CC(=O)N[C@H](C(=O)NCCCC[C@H](NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
CHEMBL2115161 86437 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 682 17 6 6 2.8 CC(=O)N[C@H](C(=O)NCCCC[C@H](NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
71456198 85350 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 565 8 2 6 4.7 COc1cc(C(=O)N(C)c2cc(C(=O)N[C@@H]3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL2112209 85350 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 565 8 2 6 4.7 COc1cc(C(=O)N(C)c2cc(C(=O)N[C@@H]3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
44299583 108447 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 473 7 1 2 5.9 NC(COCc1cc(Br)cc(Br)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL299275 108447 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 473 7 1 2 5.9 NC(COCc1cc(Br)cc(Br)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
19968650 176144 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 363 5 1 2 4.9 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1021/jm980376b
CHEMBL442028 176144 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 363 5 1 2 4.9 NC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1021/jm980376b
44319222 112920 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 657 10 1 6 5.9 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL313546 112920 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 657 10 1 6 5.9 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44326280 104854 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 297 5 1 2 4.5 Cc1cc(COC[C@@H](N)c2ccccc2)cc(C(C)(C)C)c1 10.1016/0960-894X(95)00476-A
CHEMBL273302 104854 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 297 5 1 2 4.5 Cc1cc(COC[C@@H](N)c2ccccc2)cc(C(C)(C)C)c1 10.1016/0960-894X(95)00476-A
49799942 17318 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 411 4 0 4 4.7 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL1169534 17318 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 411 4 0 4 4.7 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
44294194 183609 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 430 4 2 2 4.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1(c2ccccc2)CCNCC1 10.1016/s0960-894x(02)00249-4
CHEMBL46103 183609 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 430 4 2 2 4.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1(c2ccccc2)CCNCC1 10.1016/s0960-894x(02)00249-4
24783421 128854 0 None - 0 Mongolian jird 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596463 128854 0 None - 0 Mongolian jird 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
22850669 209765 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)80747-2
CHEMBL63109 209765 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)80747-2
22850669 209765 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
CHEMBL63109 209765 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
44289169 108265 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL297883 108265 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44358649 35562 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 631 9 1 3 7.5 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(C(c1ccccc1)c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL137868 35562 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 631 9 1 3 7.5 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(C(c1ccccc1)c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358611 35883 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 580 8 2 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(O)(c2ccccc2)CC1 10.1021/jm000986n
CHEMBL138130 35883 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 580 8 2 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(O)(c2ccccc2)CC1 10.1021/jm000986n
44358673 38237 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 493 10 1 5 4.8 COc1ccccc1C(CNC(=O)Cc1cccc(OC(C)C)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL140303 38237 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 493 10 1 5 4.8 COc1ccccc1C(CNC(=O)Cc1cccc(OC(C)C)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
44289169 108265 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL297883 108265 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
44297728 107540 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 751 8 1 5 6.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL292874 107540 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 751 8 1 5 6.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44294416 190746 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 481 7 0 5 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCN(C)C)c2nc3ccccc3nc21 10.1021/jm00109a034
74972686 190746 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 481 7 0 5 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCN(C)C)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL48173 190746 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 481 7 0 5 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCN(C)C)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL406442 219387 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
44458825 18762 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.8 CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
54428149 18762 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.8 CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
CHEMBL1183194 18762 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.8 CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
CHEMBL283990 18762 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.8 CCN1/C(=C\C=C2/CCC[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
132961 148880 15 None - 0 Human 4.9 pIC50 = 4.9 Binding
Compound was tested for its affinity towards human Tachykinin receptor 1 in [3H]-substance P(SP) binding assay on human IM9 lymphoblast cultured cell lineCompound was tested for its affinity towards human Tachykinin receptor 1 in [3H]-substance P(SP) binding assay on human IM9 lymphoblast cultured cell line
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80178-5
CHEMBL38824 148880 15 None - 0 Human 4.9 pIC50 = 4.9 Binding
Compound was tested for its affinity towards human Tachykinin receptor 1 in [3H]-substance P(SP) binding assay on human IM9 lymphoblast cultured cell lineCompound was tested for its affinity towards human Tachykinin receptor 1 in [3H]-substance P(SP) binding assay on human IM9 lymphoblast cultured cell line
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80178-5
10364942 100129 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 422 6 2 4 5.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 10.1021/jm00035a006
CHEMBL24549 100129 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 422 6 2 4 5.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 10.1021/jm00035a006
71456210 85433 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 293 2 1 2 4.1 c1ccc([C@H]2COC3(CCCN[C@H]3c3ccccc3)C2)cc1 10.1016/s0960-894x(02)00509-7
CHEMBL2112367 85433 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 293 2 1 2 4.1 c1ccc([C@H]2COC3(CCCN[C@H]3c3ccccc3)C2)cc1 10.1016/s0960-894x(02)00509-7
10364942 100129 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 422 6 2 4 5.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 10.1021/jm00066a015
CHEMBL24549 100129 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 422 6 2 4 5.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)c1 10.1021/jm00066a015
49863733 22104 0 None 2 4 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214026 22104 0 None 2 4 Human 6.9 pIC50 = 6.9 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
44326290 214182 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 271 6 1 3 3.2 COc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
CHEMBL93909 214182 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 271 6 1 3 3.2 COc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
44288789 108153 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL297134 108153 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44386105 138708 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 621 10 1 4 6.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL369498 138708 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 621 10 1 4 6.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
10429546 105833 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 375 6 1 3 4.2 CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL280422 105833 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 375 6 1 3 4.2 CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
46227361 209362 0 None -85 4 Rat 6.9 pIC50 = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611925 209362 0 None -85 4 Rat 6.9 pIC50 = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44289257 107126 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 435 6 1 3 5.2 O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL289573 107126 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 435 6 1 3 5.2 O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44289257 107126 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 435 6 1 3 5.2 O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1021/jm9700171
CHEMBL289573 107126 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 435 6 1 3 5.2 O=C(c1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1021/jm9700171
44288789 108153 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 469 6 1 3 5.9 O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1021/jm9700171
CHEMBL297134 108153 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 469 6 1 3 5.9 O=C(c1ccc(Cl)cc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1021/jm9700171
CHEMBL2369603 216415 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
44306341 210524 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 499 9 2 4 2.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)Cc1ccccc1 10.1021/jm00039a022
CHEMBL67843 210524 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 499 9 2 4 2.6 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)Cc1ccccc1 10.1021/jm00039a022
10389745 107279 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.6 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL291074 107279 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.6 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
76318227 112581 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 459 7 1 2 6.7 CCNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126964 112581 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 459 7 1 2 6.7 CCNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
11612528 112592 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 471 6 0 2 6.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126974 112592 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 471 6 0 2 6.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
44334112 11812 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 513 6 1 3 7.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc3ccccc3c2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL105201 11812 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 513 6 1 3 7.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc3ccccc3c2)c1 10.1016/S0960-894X(96)00563-X
44333950 115018 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 493 7 1 4 5.9 COc1ccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)cc1 10.1016/S0960-894X(96)00563-X
CHEMBL319700 115018 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 493 7 1 4 5.9 COc1ccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)cc1 10.1016/S0960-894X(96)00563-X
44276728 174821 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 417 4 0 2 6.1 CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL432279 174821 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 417 4 0 2 6.1 CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
44299875 201567 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
CHEMBL53846 201567 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
44274167 90225 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 541 6 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3c(Cl)cc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21991 90225 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 541 6 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3c(Cl)cc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
44276728 174821 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 417 4 0 2 6.1 CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL432279 174821 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 417 4 0 2 6.1 CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
56678621 73219 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 467 6 0 2 6.9 O=C1CCN(Cc2ccccc2-c2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817883 73219 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 467 6 0 2 6.9 O=C1CCN(Cc2ccccc2-c2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852017 73219 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 467 6 0 2 6.9 O=C1CCN(Cc2ccccc2-c2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
44306004 20106 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 539 13 4 4 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL1192152 20106 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 539 13 4 4 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL543338 20106 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 539 13 4 4 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44306694 107581 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1F)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL293164 107581 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1F)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44306354 209788 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 513 10 2 4 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCc1ccccc1 10.1021/jm00039a022
CHEMBL63249 209788 0 None - 0 Guinea pig 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 513 10 2 4 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCc1ccccc1 10.1021/jm00039a022
44312257 109687 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL306065 109687 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
44358602 34082 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 8 0 3 6.9 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136734 34082 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 8 0 3 6.9 CN(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358596 36039 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 591 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138269 36039 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 591 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
22293565 86479 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115449 86479 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
44303850 107846 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL294798 107846 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44303793 206900 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 709 13 3 9 3.6 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1Cc2ccccc2CC1C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL59615 206900 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 709 13 3 9 3.6 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1Cc2ccccc2CC1C(=O)OCc1ccccc1 10.1021/jm00089a011
68932793 131574 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 599 5 1 4 4.7 CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642173 131574 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 599 5 1 4 4.7 CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
44337795 115352 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 593 9 1 5 5.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL320308 115352 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 593 9 1 5 5.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
9978999 12256 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 411 4 2 3 5.1 Cc1cc2c(-c3ccccc3)c(NC(=O)NCc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL107618 12256 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 411 4 2 3 5.1 Cc1cc2c(-c3ccccc3)c(NC(=O)NCc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44324710 119126 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 592 14 2 4 5.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNC(C)=O)C1 10.1016/S0960-894X(01)80747-2
CHEMBL329416 119126 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 592 14 2 4 5.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNC(C)=O)C1 10.1016/S0960-894X(01)80747-2
44358435 35491 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL137792 35491 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 1 5 5.8 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44381056 64384 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 322 5 1 3 3.6 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/S0960-894X(01)80859-3
CHEMBL166816 64384 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 322 5 1 3 3.6 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/S0960-894X(01)80859-3
44294376 18824 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 482 7 1 5 5.1 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 10.1021/jm00109a034
53927094 18824 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 482 7 1 5 5.1 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183513 18824 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 482 7 1 5 5.1 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL301946 18824 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 482 7 1 5 5.1 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCC(=O)O)c2nc3ccccc3nc21 10.1021/jm00109a034
44294476 192987 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Compound was tested for binding affinity against human NK1 receptorCompound was tested for binding affinity against human NK1 receptor
ChEMBL 497 9 3 3 6.5 CC(NC(=O)[C@@](C)(Cc1cc2ccccc2[nH]1)NC(=O)OC(c1ccccc1)C(C)C)c1ccccc1 10.1016/0960-894X(95)00313-I
CHEMBL48731 192987 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Compound was tested for binding affinity against human NK1 receptorCompound was tested for binding affinity against human NK1 receptor
ChEMBL 497 9 3 3 6.5 CC(NC(=O)[C@@](C)(Cc1cc2ccccc2[nH]1)NC(=O)OC(c1ccccc1)C(C)C)c1ccccc1 10.1016/0960-894X(95)00313-I
132961 148880 15 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL38824 148880 15 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 561 7 1 4 6.6 COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)[C@](O)(c1ccccc1OC)CCC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL264353 217397 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
44346199 21019 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
CHEMBL119947 21019 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
CHEMBL2369630 216424 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44358834 37355 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 525 9 3 5 6.0 COc1ccc2oc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)cc2c1 10.1021/jm00022a010
CHEMBL139375 37355 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 525 9 3 5 6.0 COc1ccc2oc(COC(=O)N[C@](C)(Cc3c[nH]c4ccccc34)C(=O)N[C@@H](C)c3ccccc3)cc2c1 10.1021/jm00022a010
44346199 21019 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1021/jm9700171
CHEMBL119947 21019 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1021/jm9700171
44433782 152245 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 6.0 CC(C)(C)OC(=O)N1C[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2007.08.028
CHEMBL391441 152245 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 516 4 1 3 6.0 CC(C)(C)OC(=O)N1C[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2007.08.028
9832198 113532 0 None - 3 Rat 4.8 pIC50 = 4.8 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 113532 0 None - 3 Rat 4.8 pIC50 = 4.8 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
16214865 180051 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 513 4 1 3 7.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cncc12 10.1016/j.bmc.2008.05.067
CHEMBL452531 180051 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 513 4 1 3 7.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cncc12 10.1016/j.bmc.2008.05.067
44346259 120894 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 425 7 3 2 4.4 Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL332796 120894 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 425 7 3 2 4.4 Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
44346259 120894 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 425 7 3 2 4.4 Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm9700171
CHEMBL332796 120894 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 425 7 3 2 4.4 Cc1cc(C)cc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm9700171
10767359 63276 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 489 11 2 4 3.7 CCCCN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL163481 63276 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 489 11 2 4 3.7 CCCCN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44368082 51707 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 6 4.3 Cn1nnc(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 10.1016/s0960-894x(97)10163-9
CHEMBL152316 51707 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 6 4.3 Cn1nnc(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 10.1016/s0960-894x(97)10163-9
44287609 107137 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 503 6 0 5 5.4 COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL289666 107137 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 503 6 0 5 5.4 COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
44274316 172194 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 579 8 0 6 6.1 COC(=O)Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(c3ccccc3OC)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL423836 172194 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 579 8 0 6 6.1 COC(=O)Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(c3ccccc3OC)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
56666212 71416 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 442 7 1 4 4.9 COc1ccc(NC(C)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817896 71416 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 442 7 1 4 4.9 COc1ccc(NC(C)=O)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
52941489 24503 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258623 24503 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL2112243 216009 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
21994365 32231 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 463 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL135028 32231 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 463 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
44358708 36562 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 665 8 0 3 8.6 CC(C)C1CCN(C2CCN(C(CN(C)C(=O)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1021/jm000986n
CHEMBL138714 36562 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 665 8 0 3 8.6 CC(C)C1CCN(C2CCN(C(CN(C)C(=O)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1021/jm000986n
44345148 17257 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 477 5 1 3 5.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL116535 17257 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 477 5 1 3 5.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
44458598 105624 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 489 6 1 4 5.7 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL278849 105624 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 489 6 1 4 5.7 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
9954221 22305 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 426 7 1 2 5.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCCc3ccccc3)C[C@H]2Cc2ccccc2)c1 10.1021/jm9700171
CHEMBL121852 22305 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 426 7 1 2 5.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCCc3ccccc3)C[C@H]2Cc2ccccc2)c1 10.1021/jm9700171
44359025 35909 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 485 9 3 4 5.3 COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
CHEMBL138150 35909 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 485 9 3 4 5.3 COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
44306435 103564 0 None - 0 Guinea pig 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 566 9 2 5 4.2 CC(C)n1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
CHEMBL264821 103564 0 None - 0 Guinea pig 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 566 9 2 5 4.2 CC(C)n1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
44368326 179405 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 413 7 0 3 5.5 COc1ccccc1CO[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL449347 179405 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 413 7 0 3 5.5 COc1ccccc1CO[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44299750 202448 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 345 7 1 2 5.0 Cc1ccc(C)c(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL55651 202448 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 345 7 1 2 5.0 Cc1ccc(C)c(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
10483816 197977 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL51893 197977 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
10407571 174736 10 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
CHEMBL431690 174736 10 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
19797480 128324 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL358589 128324 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
10409595 11561 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 415 4 1 3 5.0 CN(Cc1ccccc1)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104075 11561 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 415 4 1 3 5.0 CN(Cc1ccccc1)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44358473 38238 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 0 3 7.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(CN1CCC(N2CCCCC2)CC1)c1ccccc1 10.1021/jm000986n
CHEMBL140304 38238 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 609 7 0 3 7.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(CN1CCC(N2CCCCC2)CC1)c1ccccc1 10.1021/jm000986n
44358801 125747 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 495 7 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1CCc2ccccc2C1)c1ccccc1 10.1021/jm00022a010
CHEMBL342386 125747 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 495 7 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1CCc2ccccc2C1)c1ccccc1 10.1021/jm00022a010
14986146 51360 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1Cc1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL152011 51360 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1Cc1ccccc1 10.1016/S0960-894X(01)81197-5
44297488 201887 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 558 9 1 6 3.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(C#N)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54996 201887 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 558 9 1 6 3.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(C#N)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44297487 202057 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL55129 202057 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10073370 66693 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 1 2 5.2 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 10.1021/jm00006a011
CHEMBL173120 66693 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 1 2 5.2 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 10.1021/jm00006a011
10045010 96966 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 375 6 1 3 4.2 CC(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23822 96966 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 375 6 1 3 4.2 CC(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44299854 107440 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 403 4 1 2 5.4 FC(F)(F)c1cc(CC[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
CHEMBL292237 107440 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 403 4 1 2 5.4 FC(F)(F)c1cc(CC[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
10041814 105651 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm00035a006
CHEMBL279050 105651 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm00035a006
10064734 129741 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm0311487
CHEMBL360815 129741 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm0311487
10041814 105651 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm00066a015
CHEMBL279050 105651 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 322 5 2 3 3.4 Cc1cc(C)cc(COC(=O)[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm00066a015
1016 10519 78 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2561 10519 78 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2733526 10519 78 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5384 10519 78 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL83 10519 78 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
DB00675 10519 78 None -39 35 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
44297424 197766 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 551 9 1 5 3.8 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL51863 197766 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 551 9 1 5 3.8 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
2247 7293 81 None -117 42 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
249 7293 81 None -117 42 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2603 7293 81 None -117 42 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
CHEMBL296419 7293 81 None -117 42 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
DB00637 7293 81 None -117 42 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
44358981 168451 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 546 10 4 4 5.5 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NC(=O)CCl)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL413122 168451 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 546 10 4 4 5.5 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NC(=O)CCl)c1)c1ccccc1 10.1021/jm00022a010
44346319 120233 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 597 9 3 6 5.9 O=C(NC1(C(=O)N[C@@H](Cc2ccc3ccccc3c2)c2nnnn2Cc2ccccc2)CCCCC1)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL331925 120233 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 597 9 3 6 5.9 O=C(NC1(C(=O)N[C@@H](Cc2ccc3ccccc3c2)c2nnnn2Cc2ccccc2)CCCCC1)c1c[nH]c2ccccc12 10.1021/jm9700171
12096357 62975 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 563 10 2 4 4.8 CC(=O)N(Cc1ccccc1Cl)C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 10.1021/jm950616c
CHEMBL162636 62975 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 563 10 2 4 4.8 CC(=O)N(Cc1ccccc1Cl)C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1 10.1021/jm950616c
44368158 128545 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 473 8 0 6 4.6 CN(Cc1nnn(C)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL358932 128545 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 473 8 0 6 4.6 CN(Cc1nnn(C)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
11518191 112590 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 457 7 1 2 6.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126972 112590 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 457 7 1 2 6.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
76314660 112595 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 445 6 1 2 6.3 CNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126977 112595 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 445 6 1 2 6.3 CNC1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
11489240 102065 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 518 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL25639 102065 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 518 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
10407571 174736 10 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
CHEMBL431690 174736 10 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
44321456 213471 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 426 8 1 3 5.5 CCOc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL89652 213471 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 426 8 1 3 5.5 CCOc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
104943 62160 39 None 1862 3 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrain; NT means not testedCompound was tested for inhibition of NK1 receptor from gerbil midbrain; NT means not tested
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL16192 62160 39 None 1862 3 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrain; NT means not testedCompound was tested for inhibition of NK1 receptor from gerbil midbrain; NT means not tested
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/0960-894X(96)00287-9
71541469 94209 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 7 0 3 5.6 CC(C)Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333634 94209 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 7 0 3 5.6 CC(C)Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
44318658 111560 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 387 4 1 5 3.4 COc1ccc(OC)c([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 10.1016/s0960-894x(02)00506-1
CHEMBL310896 111560 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 387 4 1 5 3.4 COc1ccc(OC)c([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 10.1016/s0960-894x(02)00506-1
44415540 148582 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 488 5 0 2 6.2 CN(C)C(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL386258 148582 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 488 5 0 2 6.2 CN(C)C(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
71583094 94993 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347692 94993 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
71452663 85317 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2112070 85317 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
11743207 11586 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 426 5 0 4 4.8 COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104165 11586 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 426 5 0 4 4.8 COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
10342371 11716 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 425 4 1 3 5.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL104737 11716 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 425 4 1 3 5.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44358710 36987 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 493 8 0 6 4.1 COc1ccccc1CC(=O)N(C)CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139057 36987 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 493 8 0 6 4.1 COc1ccccc1CC(=O)N(C)CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10531050 127130 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL353093 127130 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 567 12 2 5 4.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(Cc2ccccc2)CC1)C(C)=O 10.1021/jm950616c
118722856 122968 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 323 6 2 4 2.1 N#CNC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358420 122968 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 323 6 2 4 2.1 N#CNC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
44321408 113799 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 410 7 1 2 5.6 CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL315435 113799 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 410 7 1 2 5.6 CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44321408 113799 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 410 7 1 2 5.6 CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL315435 113799 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 410 7 1 2 5.6 CCc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
15037920 52503 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 430 7 1 2 5.8 Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL153042 52503 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 430 7 1 2 5.8 Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
10531291 13345 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL108304 13345 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
44380707 127350 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
CHEMBL354564 127350 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 352 6 1 4 3.6 COc1cccc([C@H]2[C@@H](NCc3ccccc3OC)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
136056467 195980 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 366 4 0 5 3.4 CCn1c(/C=C/C=C2\SCCN2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
49824386 195980 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 366 4 0 5 3.4 CCn1c(/C=C/C=C2\SCCN2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL51135 195980 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 366 4 0 5 3.4 CCn1c(/C=C/C=C2\SCCN2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
44348660 124824 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 389 0 1 4 4.1 C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nccn6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL340394 124824 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 389 0 1 4 4.1 C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nccn6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
2812 11551 101 None -43 34 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 11551 101 None -43 34 Human 4.8 pIC50 = 4.8 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
44404006 139534 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1021/jm058225d
CHEMBL370013 139534 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1021/jm058225d
10439730 113534 0 None - 3 Rat 4.8 pIC50 = 4.8 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 113534 0 None - 3 Rat 4.8 pIC50 = 4.8 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44297705 197662 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1ccccc1CNC(COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 10.1016/s0960-894x(98)00320-5
CHEMBL51849 197662 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1ccccc1CNC(COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 10.1016/s0960-894x(98)00320-5
71450949 86324 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL2114103 86324 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10055415 113533 0 None 15 3 Human 6.8 pIC50 = 6.8 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 113533 0 None 15 3 Human 6.8 pIC50 = 6.8 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10344874 126928 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
CHEMBL351387 126928 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
44386231 68154 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 607 8 1 4 6.3 COc1c(C)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1C 10.1016/0960-894X(96)00148-5
CHEMBL176951 68154 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 607 8 1 4 6.3 COc1c(C)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1C 10.1016/0960-894X(96)00148-5
15639102 121306 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 422 6 1 2 6.0 c1ccc(CN[C@H]2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL333566 121306 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 422 6 1 2 6.0 c1ccc(CN[C@H]2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
11433531 97903 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 618 7 1 3 9.4 CC(C)(C)[Si](C)(C)OCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL23982 97903 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 618 7 1 3 9.4 CC(C)(C)[Si](C)(C)OCc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
9933653 105784 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 454 7 1 2 6.4 OC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL28003 105784 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 454 7 1 2 6.4 OC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00220-N
44299444 203968 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 346 7 1 2 5.0 Cc1cc(C)cc(COCC(O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL56811 203968 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 346 7 1 2 5.0 Cc1cc(C)cc(COCC(O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
58993503 128866 0 None - 0 Mongolian jird 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 483 7 1 4 6.0 COC(=O)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596475 128866 0 None - 0 Mongolian jird 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 483 7 1 4 6.0 COC(=O)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
44297858 162544 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 589 11 2 5 5.4 CS(=O)(=O)Nc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL405820 162544 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 589 11 2 5 5.4 CS(=O)(=O)Nc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
24992986 191083 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 489 4 0 2 7.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL484133 191083 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 489 4 0 2 7.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
18654565 174708 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 698 17 0 5 7.3 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL431459 174708 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 698 17 0 5 7.3 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
10370818 169430 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 571 6 1 3 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL416983 169430 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 571 6 1 3 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44297708 201749 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 587 10 1 5 5.5 CS(=O)(=O)N1CC2(CCN(C[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54578 201749 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 587 10 1 5 5.5 CS(=O)(=O)N1CC2(CCN(C[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10834930 128279 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 365 6 1 3 4.4 FC(F)(F)Oc1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL358305 128279 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 365 6 1 3 4.4 FC(F)(F)Oc1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
44213477 212523 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 309 2 1 3 3.6 c1ccc(C2CCC3(OCCNC3c3ccccc3)OC2)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL82692 212523 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 309 2 1 3 3.6 c1ccc(C2CCC3(OCCNC3c3ccccc3)OC2)cc1 10.1016/s0960-894x(02)00506-1
10369316 94999 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 517 5 0 3 7.2 CC(C)(C)OC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347702 94999 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 517 5 0 3 7.2 CC(C)(C)OC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
44328401 119444 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 422 6 1 2 6.0 c1ccc(CNC2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
CHEMBL330362 119444 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 422 6 1 2 6.0 c1ccc(CNC2C3CC4CCCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
10835447 31507 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 411 4 0 4 4.7 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL134415 31507 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 411 4 0 4 4.7 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3ccccc3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
71583093 95004 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 1 7.1 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347851 95004 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 1 7.1 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
15755313 108976 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 649 15 4 9 2.5 CC(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C 10.1021/jm00089a011
CHEMBL302844 108976 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 649 15 4 9 2.5 CC(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C 10.1021/jm00089a011
19797425 44191 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1C 10.1021/jm00024a007
CHEMBL145500 44191 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1C 10.1021/jm00024a007
CHEMBL64037 222631 0 None - 0 Guinea pig 4.8 pIC50 = 4.8 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a011
46227360 209361 0 None -151 4 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611924 209361 0 None -151 4 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44297680 107420 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL292156 107420 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL265155 217417 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm00037a009
122182824 128869 0 None - 0 Mongolian jird 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 468 7 1 3 6.3 CN(C)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596478 128869 0 None - 0 Mongolian jird 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 468 7 1 3 6.3 CN(C)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
56681948 73244 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 436 6 0 4 5.1 O=C1CCN(Cc2ccccc2[N+](=O)[O-])CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817882 73244 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 436 6 0 4 5.1 O=C1CCN(Cc2ccccc2[N+](=O)[O-])CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852159 73244 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 436 6 0 4 5.1 O=C1CCN(Cc2ccccc2[N+](=O)[O-])CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
44335466 11826 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 720 8 2 5 6.0 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
CHEMBL105295 11826 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 720 8 2 5 6.0 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
44358783 37442 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 483 8 3 3 5.9 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1C 10.1021/jm00022a010
CHEMBL139471 37442 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 483 8 3 3 5.9 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1C 10.1021/jm00022a010
11192771 101111 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 607 8 1 3 8.5 CN(Cc1ccccc1)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL25065 101111 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 607 8 1 3 8.5 CN(Cc1ccccc1)Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
9985523 105937 0 None - 5 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1Binding affinity towards Tachykinin receptor 1
ChEMBL 572 17 2 6 6.2 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)C[C@@H]1OCc1ccccc1 10.1021/jm960281e
CHEMBL281200 105937 0 None - 5 Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards Tachykinin receptor 1Binding affinity towards Tachykinin receptor 1
ChEMBL 572 17 2 6 6.2 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)C[C@@H]1OCc1ccccc1 10.1021/jm960281e
24799546 94197 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 509 10 0 4 6.5 CC(C)CN(CC(C)C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333622 94197 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 509 10 0 4 6.5 CC(C)CN(CC(C)C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
58993452 128841 0 None - 0 Mongolian jird 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.8 Cc1nnnn1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596450 128841 0 None - 0 Mongolian jird 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.8 Cc1nnnn1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
44458786 17925 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.9 CCN1/C(=C\C=C2CC(C)[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
CHEMBL1178356 17925 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.9 CCN1/C(=C\C=C2CC(C)[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
CHEMBL23096 17925 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 3 0 3 6.9 CCN1/C(=C\C=C2CC(C)[n+]3c2n(CC)c2cc4ccccc4cc23)Sc2ccccc21 10.1021/jm00085a015
44349033 23561 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 453 0 1 4 5.6 CC#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL124532 23561 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 453 0 1 4 5.6 CC#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
22869971 172047 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 430 3 1 2 4.9 N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL42306 172047 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 430 3 1 2 4.9 N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
9981979 105934 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1C(F)(F)F)c1ccccc1 10.1021/jm00035a006
CHEMBL281194 105934 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1C(F)(F)F)c1ccccc1 10.1021/jm00035a006
44318349 212844 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 357 3 1 4 3.4 COc1cccc([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 10.1016/s0960-894x(02)00506-1
CHEMBL85414 212844 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 357 3 1 4 3.4 COc1cccc([C@H]2COCC3(C2)OCCN[C@H]3c2ccc(F)cc2)c1 10.1016/s0960-894x(02)00506-1
44277742 107551 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80349-2
CHEMBL29293 107551 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1ccccc1CO[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80349-2
44321457 174973 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
CHEMBL433336 174973 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
11633082 112579 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126962 112579 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
10650263 32859 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL135572 32859 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
10501444 108654 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL300722 108654 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
135890952 212876 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 406 4 2 6 3.4 Oc1n[nH]c(CN2CCOC3(CCC(c4ccccc4)CO3)C2c2ccccc2)n1 10.1016/s0960-894x(02)00506-1
CHEMBL85674 212876 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 406 4 2 6 3.4 Oc1n[nH]c(CN2CCOC3(CCC(c4ccccc4)CO3)C2c2ccccc2)n1 10.1016/s0960-894x(02)00506-1
11225834 105985 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 502 4 0 2 7.5 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL281491 105985 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 502 4 0 2 7.5 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
10364638 21430 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL120546 21430 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
10094248 11558 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 430 4 0 3 5.4 Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2Cl)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
CHEMBL104060 11558 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 430 4 0 3 5.4 Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2Cl)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
10006814 12014 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 0 3 6.5 CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00016a014
CHEMBL106326 12014 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 0 3 6.5 CN(Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00016a014
44288548 108035 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cc4ccccc4cn3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL296213 108035 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cc4ccccc4cn3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44288790 177133 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 472 4 1 2 5.1 CC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL44474 177133 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 472 4 1 2 5.1 CC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
21994270 33867 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 501 7 1 3 6.0 Cc1cc(C)cc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL136544 33867 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 501 7 1 3 6.0 Cc1cc(C)cc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
44312953 211337 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 682 17 6 6 2.8 CC(=O)NC(C(=O)NCCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
CHEMBL72951 211337 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 682 17 6 6 2.8 CC(=O)NC(C(=O)NCCCCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
44359088 125562 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 455 8 3 3 5.3 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)c1ccccc1 10.1021/jm00022a010
CHEMBL342044 125562 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 455 8 3 3 5.3 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)c1ccccc1 10.1021/jm00022a010
178025 125931 6 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 469 8 3 3 5.6 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
CHEMBL342924 125931 6 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 469 8 3 3 5.6 Cc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1 10.1021/jm00022a010
44305927 107388 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 541 8 2 5 3.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cc2ccccc2s1 10.1021/jm00039a022
CHEMBL291868 107388 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 541 8 2 5 3.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cc2ccccc2s1 10.1021/jm00039a022
44359111 125669 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 470 8 4 4 4.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(N)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL342260 125669 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 470 8 4 4 4.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(N)c1)c1ccccc1 10.1021/jm00022a010
10364638 21430 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL120546 21430 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 417 5 1 2 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNC2)cc(C(F)(F)F)c1 10.1021/jm9700171
44346320 120234 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.1 CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 10.1021/jm9700171
CHEMBL331926 120234 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.1 CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)C1(NC(=O)c2c[nH]c3ccccc23)CCCCC1 10.1021/jm9700171
44321442 213032 1 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL86806 213032 1 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
44334098 11888 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 477 7 1 3 6.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CCc2ccccc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL105631 11888 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 477 7 1 3 6.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CCc2ccccc2)c1 10.1016/S0960-894X(96)00563-X
44321457 174973 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 416 6 1 2 5.7 Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL433336 174973 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 416 6 1 2 5.7 Clc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
9892852 91155 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL22194 91155 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44458328 106291 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL283356 106291 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00205-8
44458983 106381 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 473 6 2 4 4.4 CC(=O)N[C@@H](Cc1n[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00035a006
CHEMBL283989 106381 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 473 6 2 4 4.4 CC(=O)N[C@@H](Cc1n[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00035a006
44458351 106166 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL282657 106166 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
44277478 174186 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1C 10.1016/S0960-894X(00)80349-2
CHEMBL429610 174186 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1C 10.1016/S0960-894X(00)80349-2
19797429 177230 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 428 7 0 4 5.4 O=[N+]([O-])c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL444872 177230 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 428 7 0 4 5.4 O=[N+]([O-])c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10745241 117308 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 549 8 3 4 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N 10.1021/jm970499g
CHEMBL325116 117308 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 549 8 3 4 4.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1N 10.1021/jm970499g
CHEMBL2369606 216418 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC2CCCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
44338530 16129 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 332 6 1 3 3.1 Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL111303 16129 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 332 6 1 3 3.1 Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44322429 213043 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 480 5 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL86890 213043 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 480 5 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44322610 213424 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 462 5 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89245 213424 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 462 5 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44346330 21339 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 522 9 4 3 4.5 O=C(N[C@H]1CCCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccccc1)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL120441 21339 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 522 9 4 3 4.5 O=C(N[C@H]1CCCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccccc1)c1c[nH]c2ccccc12 10.1021/jm9700171
18669055 11382 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 485 5 0 3 6.3 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(C)(C)C)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL102811 11382 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 485 5 0 3 6.3 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(C)(C)C)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
136180338 171965 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 502 10 2 5 5.7 CCCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL422862 171965 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 502 10 2 5 5.7 CCCN(Cc1n[nH]c(O)n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
11757401 66720 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173231 66720 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
9892852 91155 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL22194 91155 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
44458328 106291 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL283356 106291 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL281971 217626 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm9800346
44287803 106986 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 456 5 1 4 5.0 COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL288371 106986 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 456 5 1 4 5.0 COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
25176461 94178 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 404 6 0 3 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333604 94178 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 404 6 0 3 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
25176462 94179 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 390 6 1 3 4.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(C2CC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333605 94179 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 390 6 1 3 4.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(C2CC2)c1 10.1016/j.bmcl.2012.11.094
58993541 128887 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 540 8 0 3 8.0 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(Cc4ccccc4)CC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596496 128887 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 540 8 0 3 8.0 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCN(Cc4ccccc4)CC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
136043848 84726 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 528 8 2 5 5.8 CN(Cc1n[nH]c(O)n1)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL209627 84726 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 528 8 2 5 5.8 CN(Cc1n[nH]c(O)n1)C[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884433 14695 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 581 5 0 2 7.9 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090286 14695 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 581 5 0 2 7.9 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(F)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
57565074 94997 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 1 2 6.3 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNCCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347696 94997 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 1 2 6.3 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCNCCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2112240 216006 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
44358495 122926 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 7 0 3 6.4 CN(CC(c1ccccc1)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL335788 122926 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 7 0 3 6.4 CN(CC(c1ccccc1)N1CCN(C2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
10722491 126813 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 615 12 2 5 5.4 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)c1ccccc1 10.1021/jm950616c
CHEMBL350366 126813 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 615 12 2 5 5.4 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)c1ccccc1 10.1021/jm950616c
104943 62160 39 None 1862 3 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80859-3
CHEMBL16192 62160 39 None 1862 3 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80859-3
CHEMBL439019 220597 0 None 3 3 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
44294519 110286 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 6 1 4 7.2 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCC(=O)O3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085126 110286 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 610 6 1 4 7.2 CC(C(=O)NC1(c2ccccc2)CCC(N2CCC(C3CCC(=O)O3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
44407467 80738 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 410 5 2 3 5.1 FC(F)(F)Oc1ccc(Cl)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 10.1016/j.bmcl.2005.11.026
CHEMBL202141 80738 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 410 5 2 3 5.1 FC(F)(F)Oc1ccc(Cl)c(CNC2CCC3CCC2(c2ccccc2)N3)c1 10.1016/j.bmcl.2005.11.026
44415471 146338 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.0 CN(CC(N)=O)[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL379707 146338 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.0 CN(CC(N)=O)[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46830287 14762 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090648 14762 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[n+]([O-])cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
46881729 14711 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090421 14711 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
24752568 15684 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1097693 15684 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 490 4 1 3 5.0 C[C@@H](O[C@H]1CN2C(=O)C(N)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1651026 215605 24 None - 1 Human 8.7 pIC50 = 8.7 Binding
Inhibition of human tachykinin NK1 receptorInhibition of human tachykinin NK1 receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.bmc.2010.07.034
44358727 33610 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 7 0 3 6.4 CN(CC(c1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL136323 33610 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 7 0 3 6.4 CN(CC(c1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44359071 172451 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc(F)ccc1F)c1ccccc1 10.1021/jm00022a010
CHEMBL424480 172451 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc(F)ccc1F)c1ccccc1 10.1021/jm00022a010
44177670 68036 0 None -1 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766206 68036 0 None -1 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
44334108 11421 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 504 6 0 2 7.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL103085 11421 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 504 6 0 2 7.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
135767968 52144 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 386 8 2 5 3.9 Cc1cc(Cl)cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)c1 10.1016/s0960-894x(97)10163-9
CHEMBL152716 52144 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 386 8 2 5 3.9 Cc1cc(Cl)cc(COC[C@H](c2ccccc2)N(C)Cc2n[nH]c(O)n2)c1 10.1016/s0960-894x(97)10163-9
10457416 21658 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL120781 21658 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
490428 126354 6 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL346154 126354 6 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
44299273 201593 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 402 10 2 3 4.1 Cc1cc(C)cc(COCC(NCC(N)=O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL53901 201593 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 402 10 2 3 4.1 Cc1cc(C)cc(COCC(NCC(N)=O)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
24782911 128867 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596476 128867 0 None - 0 Mongolian jird 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
16663280 104737 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL272649 104737 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
16663280 104737 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL272649 104737 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 475 4 0 2 6.1 C[C@@H](O[C@H]1CN2C(=O)CC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
10744602 63155 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 523 10 2 4 4.1 CC(=O)N(Cc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL163133 63155 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 523 10 2 4 4.1 CC(=O)N(Cc1ccccc1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44274277 87850 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 551 7 1 4 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-n3cccc3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL21548 87850 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 551 7 1 4 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-n3cccc3)ccc21 10.1016/s0960-894x(01)00182-2
56681950 73239 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(OC)c1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817887 73239 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(OC)c1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852130 73239 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(OC)c1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
44415484 175717 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL438789 175717 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46884472 14767 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090653 14767 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 0 3 6.4 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc[n+]([O-])c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52947646 24017 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1256588 24017 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 620 7 1 3 7.5 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@@H](NCc4ccccc4)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
52948868 24020 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 559 5 1 3 6.5 CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
CHEMBL1256591 24020 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 559 5 1 3 6.5 CC[C@]1(O)C[C@@H]2C(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)[C@@H]3[C@@H]2C1 10.1016/j.bmcl.2010.07.058
21994340 34794 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 623 7 0 3 7.7 CN(CC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL137255 34794 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 623 7 0 3 7.7 CN(CC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
11800372 125044 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 531 3 0 4 6.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL340931 125044 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 531 3 0 4 6.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL2370874 216718 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/S0960-894X(01)80229-8
44359094 40372 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 511 8 3 4 6.5 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2s1)c1ccccc1 10.1021/jm00022a010
CHEMBL142121 40372 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 511 8 3 4 6.5 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2s1)c1ccccc1 10.1021/jm00022a010
9927183 202384 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1021/jm9700171
CHEMBL55591 202384 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1021/jm9700171
136180337 128297 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 460 8 3 5 4.6 Oc1n[nH]c(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 10.1016/s0960-894x(97)10163-9
CHEMBL358437 128297 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 460 8 3 5 4.6 Oc1n[nH]c(CN[C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)n1 10.1016/s0960-894x(97)10163-9
10834119 42405 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 351 5 1 2 5.1 Cc1cc(COCC2(c3ccccc3)CCNCC2)cc(C(C)(C)C)c1 10.1021/jm980376b
CHEMBL143974 42405 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 351 5 1 2 5.1 Cc1cc(COCC2(c3ccccc3)CCNCC2)cc(C(C)(C)C)c1 10.1021/jm980376b
CHEMBL405422 219340 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)SC)C(N)=O 10.1021/jm00037a009
44294224 110284 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 526 5 1 2 7.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCCCC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085124 110284 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 526 5 1 2 7.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N2CCCCC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
9887525 196604 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL51648 196604 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44415392 148200 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 513 7 2 4 6.1 CN(Cc1c[nH]c(O)n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL384102 148200 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 513 7 2 4 6.1 CN(Cc1c[nH]c(O)n1)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
24889113 14720 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090450 14720 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1204418 14720 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 4 6.2 C[C@@H](O[C@H]1CN2C(=O)C=C(C3COC(=O)C3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44358467 175020 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL433683 175020 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44328394 214479 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 438 7 1 3 5.3 COc1ccccc1CNC1C2C3CCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL95561 214479 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 438 7 1 3 5.3 COc1ccccc1CNC1C2C3CCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44319084 20469 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194867 20469 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553451 20469 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44319321 20476 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194933 20476 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553554 20476 0 None - 0 Guinea pig 8.6 pIC50 = 8.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
132837 9018 55 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a011
9461 9018 55 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a011
CHEMBL22870 9018 55 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a011
CHEMBL405209 219328 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
22293565 86402 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115004 86402 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 6 0 3 8.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
46881682 14869 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1091469 14869 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)C(C)(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
11654898 95005 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347852 95005 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
10369341 12526 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 1 3 6.5 Cc1ccccc1-c1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
CHEMBL107848 12526 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 4 1 3 6.5 Cc1ccccc1-c1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
9980171 16008 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 431 5 0 5 4.0 COc1ccccc1CN(C)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
CHEMBL110679 16008 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 431 5 0 5 4.0 COc1ccccc1CN(C)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
10506929 63353 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 10.1021/jm950616c
CHEMBL164175 63353 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)cc1 10.1021/jm950616c
18407045 88892 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2nc(Cl)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL21662 88892 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 521 6 1 4 6.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2nc(Cl)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL263852 217372 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)C)C(N)=O 10.1021/jm00037a009
23025481 71414 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 430 7 0 5 4.8 COc1ccc([N+](=O)[O-])cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817893 71414 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 430 7 0 5 4.8 COc1ccc([N+](=O)[O-])cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
57400460 77726 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
CHEMBL1951616 77726 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
57398780 77727 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 486 4 0 2 5.3 CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951618 77727 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 486 4 0 2 5.3 CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
46881779 15222 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1093750 15222 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 505 4 1 3 5.5 C[C@@H](O[C@H]1CN2C(=O)CC(C)(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
11561036 95006 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347853 95006 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
11539564 95007 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347854 95007 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL389651 219208 0 None 6 3 Human 8.6 pIC50 = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
10369844 106114 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 534 7 2 3 6.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1021/jm00035a006
CHEMBL282290 106114 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 534 7 2 3 6.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1021/jm00035a006
24800578 94198 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 419 6 1 4 4.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(N2CCCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333623 94198 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 419 6 1 4 4.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)nc(N2CCCC2)c1 10.1016/j.bmcl.2012.11.094
44307417 209852 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 488 8 1 3 5.7 NC(=O)CCCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63762 209852 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 488 8 1 3 5.7 NC(=O)CCCN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
57397020 77731 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 583 5 1 3 5.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
CHEMBL1951622 77731 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 583 5 1 3 5.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmc.2011.11.048
44456847 104228 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 566 6 0 2 7.4 C[C@@H](O[C@H]1CN2C(=O)N(Cc3ccccc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL270114 104228 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 566 6 0 2 7.4 C[C@@H](O[C@H]1CN2C(=O)N(Cc3ccccc3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
44415436 86734 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 NC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212644 86734 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 NC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415530 86906 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 5 2 2 5.5 CNC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213316 86906 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 5 2 2 5.5 CNC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415448 148218 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.0 CN(CC(N)=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL384157 148218 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 7 1 3 5.0 CN(CC(N)=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
46881729 14711 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1090421 14711 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)CC(O)[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
10414293 44227 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145535 44227 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
71449143 86295 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 611 5 2 3 6.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2113740 86295 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 611 5 2 3 6.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
10603019 12016 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 564 11 1 5 4.7 COc1ccccc1CN(CC(Cc1cccc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL106334 12016 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 564 11 1 5 4.7 COc1ccccc1CN(CC(Cc1cccc2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
10369653 103575 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 528 7 0 4 7.2 Cc1nc(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)cs1 10.1021/jm980376b
CHEMBL264997 103575 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 528 7 0 4 7.2 Cc1nc(CN2CCC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccccc3)CC2)cs1 10.1021/jm980376b
10624372 210487 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 475 6 0 4 5.6 COC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL67612 210487 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 475 6 0 4 5.6 COC(=O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
44318640 212635 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 399 4 1 4 4.6 COc1ccc(C(C)C)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL83716 212635 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 399 4 1 4 4.6 COc1ccc(C(C)C)cc1[C@H]1COCC2(C1)OCCN[C@H]2c1ccc(F)cc1 10.1016/s0960-894x(02)00506-1
44410155 146067 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 569 6 1 4 6.5 O=S(=O)(c1ccccc1)C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL379152 146067 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 569 6 1 4 6.5 O=S(=O)(c1ccccc1)C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
24782912 128865 0 None - 0 Mongolian jird 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 459 6 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596474 128865 0 None - 0 Mongolian jird 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 459 6 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2015.04.098
44433800 153567 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392463 153567 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)C2)CC1 10.1016/j.bmcl.2007.08.028
21994327 33702 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 591 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136411 33702 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 591 7 1 3 7.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc2ccccc12)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
10815815 126839 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 519 11 2 5 3.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N(C)C)CC1)C(C)=O 10.1021/jm950616c
CHEMBL350582 126839 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 519 11 2 5 3.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N(C)C)CC1)C(C)=O 10.1021/jm950616c
CHEMBL387670 219190 0 None 109 3 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061369n
44333964 11914 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 511 6 0 3 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CCCCC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL105763 11914 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 511 6 0 3 6.8 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC3CCCCC3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
10837611 39015 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 459 6 0 2 6.7 CC(C)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL140982 39015 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 459 6 0 2 6.7 CC(C)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
10669293 40218 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 373 5 1 2 4.6 Cc1cc(Br)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL141994 40218 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 373 5 1 2 4.6 Cc1cc(Br)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
44274362 175970 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 4 5.4 Cn1c(-c2ccccn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL440649 175970 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 487 6 1 4 5.4 Cn1c(-c2ccccn2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00183-4
CHEMBL2372518 217046 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
2102 7972 21 None 2 2 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(01)00044-0
5311057 7972 21 None 2 2 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(01)00044-0
CHEMBL441225 7972 21 None 2 2 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/s0960-894x(01)00044-0
44358767 33883 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 593 7 1 3 6.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136559 33883 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 593 7 1 3 6.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(Cl)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358741 37855 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 491 7 0 5 4.7 Cc1cc(C)cc(CC(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL139967 37855 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 491 7 0 5 4.7 Cc1cc(C)cc(CC(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL2371977 216950 0 None 17 3 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
11705830 112591 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 489 9 0 3 6.3 COCCN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126973 112591 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 489 9 0 3 6.3 COCCN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
10318976 214070 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 5 1 2 5.5 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
CHEMBL93216 214070 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for human NK1 receptor expressed in CHO cellsBinding affinity for human NK1 receptor expressed in CHO cells
ChEMBL 403 5 1 2 5.5 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80585-0
44326306 119113 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 319 5 1 2 4.0 Cc1cc(Br)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
CHEMBL329325 119113 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 319 5 1 2 4.0 Cc1cc(Br)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
44321442 213032 1 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00092a009
CHEMBL86806 213032 1 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00092a009
24800743 94192 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 411 6 1 4 4.1 CN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCNCC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333617 94192 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 411 6 1 4 4.1 CN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCNCC2)n1 10.1016/j.bmcl.2012.11.094
44433802 153569 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392464 153569 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@@H](c3nc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)no3)[C@H](c3ccc(F)cc3C)C2)CC1 10.1016/j.bmcl.2007.08.028
44335376 11317 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 717 7 2 4 6.3 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
CHEMBL102376 11317 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 717 7 2 4 6.3 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
44370369 55678 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 541 12 1 3 7.0 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
CHEMBL155976 55678 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 541 12 1 3 7.0 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
44288951 107258 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 515 5 2 2 5.6 CC(C)NC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL290926 107258 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 515 5 2 2 5.6 CC(C)NC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
19797419 172039 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL423019 172039 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44380708 64348 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 356 5 1 3 4.3 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 10.1016/S0960-894X(01)80859-3
CHEMBL166610 64348 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 356 5 1 3 4.3 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 10.1016/S0960-894X(01)80859-3
9329 10513 5 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
9894349 10513 5 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
CHEMBL339486 10513 5 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10.1021/jm990220r
44277726 105886 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 397 6 0 2 5.8 Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL280849 105886 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 397 6 0 2 5.8 Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL413827 219867 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
44177145 202507 0 None -6 3 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1191 27 10 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL557188 202507 0 None -6 3 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1191 27 10 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
44410321 148022 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 443 4 1 2 6.6 C[C@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL382988 148022 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 443 4 1 2 6.6 C[C@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
58993596 128843 0 None - 0 Mongolian jird 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 417 6 2 5 3.7 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nnn[nH]2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596452 128843 0 None - 0 Mongolian jird 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 417 6 2 5 3.7 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nnn[nH]2)c1 10.1016/j.bmcl.2015.04.098
44324706 214045 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 696 16 0 4 7.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C)cc(C)c2)C1 10.1016/S0960-894X(01)80747-2
CHEMBL93038 214045 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 696 16 0 4 7.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2cc(C)cc(C)c2)C1 10.1016/S0960-894X(01)80747-2
44348756 22340 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 429 0 1 4 5.6 C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@]2(C)O)nc1ccccc14 10.1021/jm00080a025
CHEMBL122020 22340 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 429 0 1 4 5.6 C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@]2(C)O)nc1ccccc14 10.1021/jm00080a025
10627355 126788 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
CHEMBL350151 126788 0 None - 0 Mouse 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
44297520 202862 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 443 6 1 5 1.9 CS(=O)(=O)N1CC2(CCN(C(=O)C(N)COCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL56069 202862 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 443 6 1 5 1.9 CS(=O)(=O)N1CC2(CCN(C(=O)C(N)COCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44294355 18014 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 453 5 1 5 3.7 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
49824390 18014 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 453 5 1 5 3.7 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1178897 18014 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 453 5 1 5 3.7 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL48454 18014 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 453 5 1 5 3.7 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CC(N)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
12225557 127955 1 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(01)81197-5
CHEMBL357717 127955 1 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(01)81197-5
156500036 193223 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of NK1 (unknown origin)Inhibition of NK1 (unknown origin)
ChEMBL 428 5 3 4 3.9 Cc1c(C2(c3ccc(C(F)(F)F)c(C#N)c3)CC2)c[nH]c1C(=O)NC(C)c1nc[nH]n1 10.1021/acs.jmedchem.1c00173
CHEMBL4876457 193223 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of NK1 (unknown origin)Inhibition of NK1 (unknown origin)
ChEMBL 428 5 3 4 3.9 Cc1c(C2(c3ccc(C(F)(F)F)c(C#N)c3)CC2)c[nH]c1C(=O)NC(C)c1nc[nH]n1 10.1021/acs.jmedchem.1c00173
136046099 17926 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 430 4 0 2 6.0 CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
49824391 17926 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 430 4 0 2 6.0 CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL1178358 17926 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 430 4 0 2 6.0 CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL23181 17926 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 430 4 0 2 6.0 CCn1c(/C=C/C=c2/c3cccc4cccc(c43)n2C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
10456618 139013 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 454 4 1 2 5.3 O=C1CC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL369692 139013 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 454 4 1 2 5.3 O=C1CC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
10698161 11967 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 10 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL106083 11967 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 10 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
11363490 100831 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 474 4 1 2 6.9 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
CHEMBL24894 100831 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 474 4 1 2 6.9 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
44359054 38600 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 555 8 3 3 7.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1c2ccccc2cc2ccccc12)c1ccccc1 10.1021/jm00022a010
CHEMBL140659 38600 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 555 8 3 3 7.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1c2ccccc2cc2ccccc12)c1ccccc1 10.1021/jm00022a010
10556941 105990 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL 738 21 2 7 7.7 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccc(F)cc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm9800346
CHEMBL281530 105990 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL 738 21 2 7 7.7 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccc(F)cc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm9800346
44333561 11442 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 488 6 1 4 5.7 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C#N)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL103221 11442 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 488 6 1 4 5.7 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(C#N)cc2)c1 10.1016/S0960-894X(96)00563-X
21753665 206457 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 387 8 1 2 5.2 CC(=O)NC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL59310 206457 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 387 8 1 2 5.2 CC(=O)NC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
10811257 108604 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL300303 108604 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
16755279 181872 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 547 4 0 5 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL456875 181872 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 547 4 0 5 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL413827 219867 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
44277726 105886 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
CHEMBL280849 105886 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
10350454 113508 0 None 10 3 Human 7.7 pIC50 = 7.7 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 113508 0 None 10 3 Human 7.7 pIC50 = 7.7 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44312951 109979 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 668 16 6 6 2.4 CC(=O)NC(C(=O)NCCCC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
CHEMBL308363 109979 0 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 668 16 6 6 2.4 CC(=O)NC(C(=O)NCCCC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)[C@@H](C)O 10.1021/jm00068a003
9831641 86472 5 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL2115415 86472 5 None - 0 Guinea pig 7.7 pIC50 = 7.7 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
10071124 105569 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm9700171
CHEMBL278351 105569 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm9700171
10506376 62631 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 529 10 2 4 4.4 CC(=O)N(CC1CCCCC1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL162330 62631 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 529 10 2 4 4.4 CC(=O)N(CC1CCCCC1)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44304144 20208 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 597 15 4 8 1.8 NC(=O)CC[C@H](N)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL1192961 20208 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 597 15 4 8 1.8 NC(=O)CC[C@H](N)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL544284 20208 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 597 15 4 8 1.8 NC(=O)CC[C@H](N)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44288772 162384 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 413 6 1 3 4.7 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccncc3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL40455 162384 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 413 6 1 3 4.7 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccncc3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44358416 34083 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 631 10 1 6 6.1 COc1ccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC 10.1021/jm000986n
CHEMBL136735 34083 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 631 10 1 6 6.1 COc1ccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c(OC)c1OC 10.1021/jm000986n
44383969 135824 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL367034 135824 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
10412224 93497 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(C(F)(F)F)cc1)c1ccccc1 10.1021/jm00035a006
CHEMBL23184 93497 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(C(F)(F)F)cc1)c1ccccc1 10.1021/jm00035a006
44324845 176072 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 634 16 1 4 7.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C(C)C)C(C)C)C1 10.1016/S0960-894X(01)80747-2
CHEMBL441458 176072 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 634 16 1 4 7.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C(C)C)C(C)C)C1 10.1016/S0960-894X(01)80747-2
104943 62160 39 None 1862 3 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
CHEMBL16192 62160 39 None 1862 3 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00006a012
10071124 105569 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL278351 105569 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00006a012
10004190 136865 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 456 4 1 3 5.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL367711 136865 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 456 4 1 3 5.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
10071124 105569 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
CHEMBL278351 105569 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
44294481 110285 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 486 5 1 2 6.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N(C)C)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
CHEMBL3085125 110285 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cells
ChEMBL 486 5 1 2 6.3 CC(C(=O)N[C@]1(c2ccccc2)CC[C@H](N(C)C)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00250-0
24799711 94207 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 412 6 0 4 4.4 COc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333632 94207 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 412 6 0 4 4.4 COc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
42639650 194974 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 569 5 0 3 8.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL499004 194974 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 569 5 0 3 8.1 C[C@@H](O[C@H]1CC[C@@H]2CN(C3=CC(=O)CCC3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44358552 125963 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 539 8 0 5 5.7 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm000986n
CHEMBL343150 125963 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 539 8 0 5 5.7 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm000986n
44270411 18755 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 453 9 1 2 5.8 C=CC[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1183074 18755 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 453 9 1 2 5.8 C=CC[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL278487 18755 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 453 9 1 2 5.8 C=CC[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
44359096 35904 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 469 8 3 3 5.6 Cc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/jm00022a010
CHEMBL138146 35904 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 469 8 3 3 5.6 Cc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/jm00022a010
46227363 206444 0 None -28 4 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL592969 206444 0 None -28 4 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44212281 137394 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1cccc(OC)c1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL368159 137394 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1cccc(OC)c1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
44346420 21077 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1021/jm9700171
CHEMBL119990 21077 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1021/jm9700171
10393324 127587 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 574 5 2 3 6.8 O=C1C(Cc2c[nH]c3ccccc23)N(C(=O)Nc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL355643 127587 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 574 5 2 3 6.8 O=C1C(Cc2c[nH]c3ccccc23)N(C(=O)Nc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
56675185 73221 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccc(C(F)(F)F)cc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817834 73221 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccc(C(F)(F)F)cc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852026 73221 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccc(C(F)(F)F)cc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
68870199 131572 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 535 5 0 3 5.8 CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642171 131572 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 535 5 0 3 5.8 CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
44348605 119874 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 415 0 1 4 5.2 C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@@H]2O)nc1ccccc14 10.1021/jm00080a025
CHEMBL331346 119874 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 415 0 1 4 5.2 C[C@]12Cc3cn4c(nc3CC1CCC1C2CC[C@@]2(C)C1CC[C@@H]2O)nc1ccccc14 10.1021/jm00080a025
44288892 108282 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 412 6 1 2 5.3 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccccc3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL297970 108282 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 412 6 1 2 5.3 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccccc3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44289168 175860 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL43977 175860 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL2112246 216012 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
71461705 86393 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL2114963 86393 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
9914897 185837 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter as radioligandCompound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter as radioligand
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
CHEMBL47146 185837 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter as radioligandCompound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter as radioligand
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
21994362 36500 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 465 9 1 5 4.1 COc1ccc(CC(=O)NCC(c2ccccc2OC)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm000986n
CHEMBL138666 36500 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 465 9 1 5 4.1 COc1ccc(CC(=O)NCC(c2ccccc2OC)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm000986n
9914897 185837 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
CHEMBL47146 185837 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
44212688 161825 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 375 8 1 3 4.5 COc1cc(CNC(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 10.1016/S0960-894X(96)00280-6
CHEMBL40164 161825 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 375 8 1 3 4.5 COc1cc(CNC(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 10.1016/S0960-894X(96)00280-6
44212684 169758 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 389 8 0 3 4.9 COc1cc(CN(C)C(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 10.1016/S0960-894X(96)00280-6
CHEMBL417519 169758 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 389 8 0 3 4.9 COc1cc(CN(C)C(=O)CC(c2ccccc2)c2ccccc2)cc(OC)c1 10.1016/S0960-894X(96)00280-6
44287557 175475 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 383 6 1 1 5.8 O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(96)00280-6
CHEMBL436698 175475 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 383 6 1 1 5.8 O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(Cl)cc(Cl)c1 10.1016/S0960-894X(96)00280-6
15037919 126405 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 396 6 1 2 5.4 Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346633 126405 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 396 6 1 2 5.4 Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44307409 109034 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 353 7 2 4 2.5 COc1ccccc1CN[C@H]1CCCN(CC(N)=O)[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL303181 109034 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 353 7 2 4 2.5 COc1ccccc1CN[C@H]1CCCN(CC(N)=O)[C@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
10458783 105392 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 504 5 2 3 6.4 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
CHEMBL277004 105392 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 504 5 2 3 6.4 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
44312219 109158 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 506 6 3 2 5.1 O=C(NCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL303868 109158 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 506 6 3 2 5.1 O=C(NCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
15639130 120292 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 422 6 1 2 5.7 c1ccc(CN[C@H]2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL332106 120292 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 422 6 1 2 5.7 c1ccc(CN[C@H]2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
44346524 120298 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 360 4 1 2 4.9 Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 10.1021/jm9700171
CHEMBL332140 120298 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 360 4 1 2 4.9 Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 10.1021/jm9700171
10484232 202208 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL55229 202208 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
22859118 174992 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 445 8 2 5 4.3 FC(F)(F)c1cc(COC[C@@H](NCc2nn[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(97)10163-9
CHEMBL433539 174992 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 445 8 2 5 4.3 FC(F)(F)c1cc(COC[C@@H](NCc2nn[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(97)10163-9
44346420 21077 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Compound was evaluated for binding affinity against human Tachykinin receptor 1Compound was evaluated for binding affinity against human Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
CHEMBL119990 21077 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Compound was evaluated for binding affinity against human Tachykinin receptor 1Compound was evaluated for binding affinity against human Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
58993475 128853 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596462 128853 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
46884434 14697 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 593 6 1 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090288 14697 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 593 6 1 3 7.3 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(CO)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44306252 108986 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 602 8 2 5 4.6 Cc1ccc2cc(C[C@@H](NC(=O)C3C[C@@H](O)CN3C(=O)c3cn(C)c4ccccc34)C(=O)N(C)Cc3ccccc3)ccc2c1 10.1021/jm00039a022
CHEMBL302892 108986 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 602 8 2 5 4.6 Cc1ccc2cc(C[C@@H](NC(=O)C3C[C@@H](O)CN3C(=O)c3cn(C)c4ccccc34)C(=O)N(C)Cc3ccccc3)ccc2c1 10.1021/jm00039a022
44306226 109019 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 496 9 3 3 4.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(C)(C)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL303116 109019 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 496 9 3 3 4.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(C)(C)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
10005824 12675 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 491 5 0 3 7.0 Cn1c(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)c2ccccc2c1=O 10.1021/jm00016a014
CHEMBL107959 12675 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 491 5 0 3 7.0 Cn1c(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)c2ccccc2c1=O 10.1021/jm00016a014
9868622 12969 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 455 5 1 4 5.5 COc1ccccc1CN(C)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
CHEMBL108126 12969 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 455 5 1 4 5.5 COc1ccccc1CN(C)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
9888665 128759 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL359206 128759 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44312256 211359 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 554 7 2 5 5.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL73097 211359 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 554 7 2 5 5.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
44312888 103511 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 626 14 6 6 1.4 C[C@@H](O)C(NC(=O)CC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O 10.1021/jm00068a003
CHEMBL264384 103511 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 626 14 6 6 1.4 C[C@@H](O)C(NC(=O)CC(NC(=O)c1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O 10.1021/jm00068a003
44319340 212692 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 707 10 0 6 7.2 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL84055 212692 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 707 10 0 6 7.2 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44319250 113784 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 589 10 1 6 4.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315322 113784 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 589 10 1 6 4.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
158365 195502 6 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of substance P receptorInhibition of substance P receptor
ChEMBL 664 5 4 6 3.1 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1([C@]34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 10.1021/np50111a008
CHEMBL504788 195502 6 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of substance P receptorInhibition of substance P receptor
ChEMBL 664 5 4 6 3.1 O=C1N[C@@H](Cc2ccccc2)C(=O)N2[C@H]1C[C@]1([C@]34C[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)N5[C@H]3Nc3ccccc34)c3ccccc3N[C@H]21 10.1021/np50111a008
44346524 120298 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 360 4 1 2 4.9 Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
CHEMBL332140 120298 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 360 4 1 2 4.9 Clc1cccc([C@H]2[C@@H](NCc3ccccc3Cl)C3CCN2CC3)c1 10.1016/S0960-894X(01)80859-3
44328407 114084 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 422 6 1 2 5.7 c1ccc(CNC2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
CHEMBL317289 114084 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 422 6 1 2 5.7 c1ccc(CNC2C3C4CCCC3CN(C4)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
CHEMBL406812 219400 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(N)=O 10.1021/jm00037a009
44344209 121327 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@@H](C)c2ccccc2)c1 10.1016/S0960-894X(96)00623-3
CHEMBL333726 121327 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@@H](C)c2ccccc2)c1 10.1016/S0960-894X(96)00623-3
44375297 63566 0 None - 0 Guinea pig 5.6 pIC50 = 5.6 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
CHEMBL164361 63566 0 None - 0 Guinea pig 5.6 pIC50 = 5.6 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
19003143 210637 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COCC(N)Cc2ccc3ccccc3c2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL68670 210637 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COCC(N)Cc2ccc3ccccc3c2)c1 10.1016/S0960-894X(00)80063-3
10448006 210676 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 308 6 2 2 3.9 Cc1cc(C)cc(COCC(N)Cc2c[nH]c3ccccc23)c1 10.1016/S0960-894X(00)80063-3
CHEMBL68934 210676 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 308 6 2 2 3.9 Cc1cc(C)cc(COCC(N)Cc2c[nH]c3ccccc23)c1 10.1016/S0960-894X(00)80063-3
44321047 212960 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 10.1021/jm9700171
CHEMBL86378 212960 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 10.1021/jm9700171
44346550 21460 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COC[C@@H](N)Cc2ccc3ccccc3c2)c1 10.1021/jm9700171
CHEMBL120589 21460 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 319 6 1 2 4.5 Cc1cc(C)cc(COC[C@@H](N)Cc2ccc3ccccc3c2)c1 10.1021/jm9700171
44346476 120903 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 308 6 2 2 3.9 Cc1cc(C)cc(COC[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm9700171
CHEMBL332843 120903 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 308 6 2 2 3.9 Cc1cc(C)cc(COC[C@@H](N)Cc2c[nH]c3ccccc23)c1 10.1021/jm9700171
44287210 107144 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.6 O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL289728 107144 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.6 O=C(CC(c1ccccc1)c1ccccc1)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
54582278 67927 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 472 5 1 2 6.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)ccnc1CCl 10.1016/j.bmc.2011.02.031
CHEMBL1765497 67927 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 472 5 1 2 6.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)ccnc1CCl 10.1016/j.bmc.2011.02.031
16755278 196765 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 533 4 1 5 6.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL517102 196765 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 533 4 1 5 6.1 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccc(F)cc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL302668 217692 0 None - 0 Guinea pig 4.6 pIC50 = 4.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O)OCc1ccccc1 10.1021/jm00089a011
44297648 199358 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 600 9 2 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(CNCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL52139 199358 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 600 9 2 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(CNCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL5286807 201136 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 381 2 1 3 4.4 Fc1ccc([C@@H]2NCCO[C@@]23C[C@@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1021/acs.jmedchem.1c00790
44318406 176484 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2C(F)(F)F)C3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL443799 176484 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2C(F)(F)F)C3)cc1 10.1016/s0960-894x(02)00506-1
24782915 128857 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596466 128857 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44433795 95546 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cncnc2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL236304 95546 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2cncnc2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
18709628 173587 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 2 5 4.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccccc1OC)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42845 173587 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 515 12 2 5 4.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccccc1OC)C(C)=O 10.1016/s0960-894x(01)00250-5
9873546 84812 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 566 8 1 2 7.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1 10.1021/jm060439n
CHEMBL209899 84812 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 566 8 1 2 7.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1 10.1021/jm060439n
44348667 121105 1 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL124542 121105 1 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL333069 121105 1 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44288926 108260 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 591 6 1 3 6.8 O=C(c1cc(Br)cc(Br)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL297833 108260 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 591 6 1 3 6.8 O=C(c1cc(Br)cc(Br)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
104943 62160 39 None - 3 Mouse 7.6 pIC50 = 7.6 Binding
Inhibitory activity against NK-1 receptors in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against NK-1 receptors in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 62160 39 None - 3 Mouse 7.6 pIC50 = 7.6 Binding
Inhibitory activity against NK-1 receptors in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against NK-1 receptors in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
25129133 195666 0 None -10 4 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL507340 195666 0 None -10 4 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44303794 107607 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 711 16 3 9 3.7 CN(C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL293355 107607 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 711 16 3 9 3.7 CN(C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
71699790 131561 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642160 131561 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
44381059 64608 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 356 5 1 3 4.3 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 10.1016/S0960-894X(01)80859-3
CHEMBL167066 64608 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 356 5 1 3 4.3 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1cccc(Cl)c1 10.1016/S0960-894X(01)80859-3
CHEMBL2112246 216012 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
CHEMBL2372444 217024 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
10478708 214352 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 445 8 1 1 6.1 O=C(NCCc1ccccc1)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 10.1016/S0960-894X(01)80821-0
CHEMBL94883 214352 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 445 8 1 1 6.1 O=C(NCCc1ccccc1)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 10.1016/S0960-894X(01)80821-0
CHEMBL5273060 200525 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomesInhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomes
ChEMBL 1264 38 15 16 -2.1 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)O 10.1021/acs.jmedchem.6b01029
21994346 36998 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 435 8 1 4 4.0 COc1ccccc1C(CNC(=O)Cc1ccccc1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139071 36998 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 435 8 1 4 4.0 COc1ccccc1C(CNC(=O)Cc1ccccc1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
44312324 211463 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 534 7 2 2 5.8 CCN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73896 211463 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 534 7 2 2 5.8 CCN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
15295988 67847 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 455 4 2 2 4.7 O=C1CNC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL176471 67847 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 455 4 2 2 4.7 O=C1CNC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
10477953 105711 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(Cl)cc1)c1ccccc1 10.1021/jm00035a006
CHEMBL279500 105711 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccc(Cl)cc1)c1ccccc1 10.1021/jm00035a006
19797451 43581 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL145008 43581 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 397 6 0 2 5.8 Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44307118 209789 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 4 1 3 4.5 NC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63257 209789 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 474 4 1 3 4.5 NC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
24782656 128860 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 440 6 2 3 5.8 Nc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596469 128860 0 None - 0 Mongolian jird 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 440 6 2 3 5.8 Nc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44338639 12498 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL107831 12498 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COC[C@@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44338532 14402 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 324 6 1 3 3.5 Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL108822 14402 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 324 6 1 3 3.5 Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44322735 112754 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 472 6 1 2 5.7 Cc1cccc(CN(C(=O)CCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL313070 112754 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 472 6 1 2 5.7 Cc1cccc(CN(C(=O)CCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
44322728 213448 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 494 6 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89425 213448 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 494 6 1 3 5.5 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cccc(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
9801487 213777 0 None 5 2 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL91418 213777 0 None 5 2 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
25129133 195666 0 None -10 4 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL507340 195666 0 None -10 4 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
44306034 109504 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 631 10 3 7 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(NS(C)(=O)=O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL304897 109504 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 631 10 3 7 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(NS(C)(=O)=O)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL2369763 216460 9 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/0960-894X(94)85022-4
10027061 21724 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 456 4 1 3 5.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL120844 21724 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 456 4 1 3 5.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
44346175 19163 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 494 5 1 2 6.3 Cc1cc(C)cc(C(=O)N[C@H]2CCN(C(=O)c3cc(Cl)cc(Cl)c3)[C@H](Cc3ccccc3)C2)c1 10.1021/jm9700171
CHEMBL118565 19163 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 494 5 1 2 6.3 Cc1cc(C)cc(C(=O)N[C@H]2CCN(C(=O)c3cc(Cl)cc(Cl)c3)[C@H](Cc3ccccc3)C2)c1 10.1021/jm9700171
22293526 86482 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.4 O=C(NC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL2115452 86482 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.4 O=C(NC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
68932391 131566 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1 nan
CHEMBL3642165 131566 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1 nan
10459262 11654 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 5 1 3 7.2 Cc1cc2c(-c3ccccc3)c(CNCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL104435 11654 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 518 5 1 3 7.2 Cc1cc2c(-c3ccccc3)c(CNCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44370954 175111 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 558 10 1 6 4.5 COC(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL434272 175111 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 558 10 1 6 4.5 COC(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
1122655 129876 24 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 421 6 1 6 4.7 O=C(CSc1nnc(-c2ccncc2)n1-c1ccccc1)Nc1cccc(Cl)c1 10.1021/jm0311487
CHEMBL361031 129876 24 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 421 6 1 6 4.7 O=C(CSc1nnc(-c2ccncc2)n1-c1ccccc1)Nc1cccc(Cl)c1 10.1021/jm0311487
21994363 126135 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 488 7 1 3 5.6 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1 10.1021/jm000986n
CHEMBL344370 126135 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 488 7 1 3 5.6 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1 10.1021/jm000986n
CHEMBL2112245 216011 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
44308931 211117 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@H](N)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL71553 211117 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@H](N)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL2372517 217045 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
44298065 202480 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 553 9 1 5 3.9 CS(=O)(=O)N1CCC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)C1 10.1016/s0960-894x(98)00319-9
CHEMBL55691 202480 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 553 9 1 5 3.9 CS(=O)(=O)N1CCC2(CCN(C(=O)[C@H](COCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)C1 10.1016/s0960-894x(98)00319-9
CHEMBL62581 222624 0 None - 0 Guinea pig 5.6 pIC50 = 5.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/jm00089a011
10769264 15988 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 10 2 3 5.0 CN(CCc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL110508 15988 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 10 2 3 5.0 CN(CCc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
25129135 179376 0 None -1584 4 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
CHEMBL448998 179376 0 None -1584 4 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
44384678 68145 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 697 11 1 8 6.2 CCOC(=O)Oc1c(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1OC 10.1016/0960-894X(96)00148-5
CHEMBL176860 68145 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 697 11 1 8 6.2 CCOC(=O)Oc1c(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1OC 10.1016/0960-894X(96)00148-5
19797431 44209 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL145514 44209 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44299814 174741 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 415 3 1 2 5.0 O=C1CO[C@@H](/C=C/c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccccc2)N1 10.1016/S0960-894X(01)80534-5
CHEMBL431725 174741 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 415 3 1 2 5.0 O=C1CO[C@@H](/C=C/c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccccc2)N1 10.1016/S0960-894X(01)80534-5
11409185 106199 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL282853 106199 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
11329897 98673 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 522 5 1 2 7.6 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CCl)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL24136 98673 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 522 5 1 2 7.6 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(CCl)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
10004190 136865 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 456 4 1 3 5.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL367711 136865 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 456 4 1 3 5.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
44287443 107048 1 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 528 9 0 5 4.9 CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL288942 107048 1 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 528 9 0 5 4.9 CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
16755255 195910 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 529 4 0 5 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL510547 195910 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 529 4 0 5 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
11642147 94991 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 521 7 0 2 7.9 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347690 94991 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 521 7 0 2 7.9 FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
44288927 175557 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 503 6 1 3 6.5 O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL43744 175557 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 503 6 1 3 6.5 O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44359109 38744 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)cc1)c1ccccc1 10.1021/jm00022a010
CHEMBL140768 38744 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)cc1)c1ccccc1 10.1021/jm00022a010
44297563 201736 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 615 8 1 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54435 201736 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 615 8 1 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44415393 87153 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 500 7 2 3 5.4 O=C1CC[C@@H](CN[C@H]2CC[C@@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)N1 10.1016/j.bmcl.2006.06.035
CHEMBL214435 87153 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 500 7 2 3 5.4 O=C1CC[C@@H](CN[C@H]2CC[C@@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)N1 10.1016/j.bmcl.2006.06.035
15755298 205495 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 732 15 4 9 5.0 CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL58245 205495 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 732 15 4 9 5.0 CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
71699789 131560 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 529 4 0 3 5.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642159 131560 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 529 4 0 3 5.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL2112245 216011 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against human wild type NK1 receptor expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
44294394 18024 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 495 6 0 5 4.7 CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
53838756 18024 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 495 6 0 5 4.7 CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1178980 18024 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 495 6 0 5 4.7 CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL52448 18024 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 495 6 0 5 4.7 CCn1c(/C=C/C=C2/N(CC(=O)N(C)C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
44297753 169458 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 526 10 1 4 6.1 COc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL417026 169458 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 526 10 1 4 6.1 COc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
10318912 104267 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 402 4 0 1 7.0 FC(F)(F)c1cc(CO[C@H]2CCCC[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
CHEMBL27026 104267 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 402 4 0 1 7.0 FC(F)(F)c1cc(CO[C@H]2CCCC[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
10249652 136511 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 388 4 1 3 4.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL367423 136511 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 388 4 1 3 4.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 10.1021/jm00006a011
15295989 66454 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 441 4 2 1 5.3 O=C1NC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL172238 66454 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 441 4 2 1 5.3 O=C1NC(Cc2c[nH]c3ccccc23)CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
44324746 214077 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 565 14 1 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCOC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL93251 214077 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 565 14 1 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCOC)C1 10.1016/S0960-894X(01)80747-2
44334185 11340 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 449 5 1 3 6.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL102525 11340 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 449 5 1 3 6.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 10.1016/S0960-894X(96)00563-X
44346664 23325 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 388 4 1 3 4.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL123764 23325 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 388 4 1 3 4.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1cccc(C(F)(F)F)c1 10.1021/jm9700171
44334185 11340 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 449 5 1 3 6.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 10.1021/jm9700171
CHEMBL102525 11340 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 449 5 1 3 6.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2c2ccccc2)c1 10.1021/jm9700171
44297466 108683 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL300896 108683 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccc(Cl)cc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44333727 115995 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 493 7 1 4 5.9 COc1cccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL321710 115995 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 493 7 1 4 5.9 COc1cccc(C[C@@H]2C[C@@H](NCc3ccnc4ccccc34)CCN2C(=O)c2cc(C)cc(C)c2)c1 10.1016/S0960-894X(96)00563-X
10627789 107354 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL 630 18 3 7 5.3 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O 10.1021/jm9800346
CHEMBL29161 107354 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL 630 18 3 7 5.3 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O 10.1021/jm9800346
24889458 15202 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 6 0 5 6.7 CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1093594 15202 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 6 0 5 6.7 CCc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
10790827 126689 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 478 10 2 5 2.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCOCC1)C(C)=O 10.1021/jm950616c
CHEMBL349273 126689 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 478 10 2 5 2.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCOCC1)C(C)=O 10.1021/jm950616c
44306309 107771 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 622 8 2 5 4.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2cc(Cl)ccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL294342 107771 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 622 8 2 5 4.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2cc(Cl)ccc2c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
10840510 172069 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 555 11 2 6 4.0 COc1ccccc1CN(CC(CC1CNc2ccccc21)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL423254 172069 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 555 11 2 6 4.0 COc1ccccc1CN(CC(CC1CNc2ccccc21)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
54581251 67925 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 472 4 1 2 6.7 Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765495 67925 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 472 4 1 2 6.7 Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
56681832 73252 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2cccc(C(F)(F)F)c2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817833 73252 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2cccc(C(F)(F)F)c2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852229 73252 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2cccc(C(F)(F)F)c2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
21994308 37217 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 503 8 1 4 5.1 COc1ccccc1C(CNC(=O)Cc1ccccc1C(F)(F)F)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139256 37217 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 503 8 1 4 5.1 COc1ccccc1C(CNC(=O)Cc1ccccc1C(F)(F)F)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
10506124 108037 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL296228 108037 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
44344995 103231 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2\CC[C@@H](NC(=O)c3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL262301 103231 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2\CC[C@@H](NC(=O)c3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
44290659 108310 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL298247 108310 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL264341 217393 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C(=C/c1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
CHEMBL269584 217578 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm00037a009
44337703 117464 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 603 9 2 6 4.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(=N/c1ccccc1[N+](=O)[O-])NC#N 10.1021/jm970499g
CHEMBL326001 117464 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 603 9 2 6 4.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(=N/c1ccccc1[N+](=O)[O-])NC#N 10.1021/jm970499g
CHEMBL2369630 216424 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44212285 130596 1 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1016/0960-894X(96)00148-5
CHEMBL362394 130596 1 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1016/0960-894X(96)00148-5
44276738 103965 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 560 6 0 2 7.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL26831 103965 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 560 6 0 2 7.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
10045837 68151 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 388 4 1 3 4.6 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(Cl)cc(Cl)c1 10.1021/jm00006a011
CHEMBL176919 68151 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 388 4 1 3 4.6 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(Cl)cc(Cl)c1 10.1021/jm00006a011
CHEMBL2369605 216417 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None CC(C)C[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm960281e
16755280 183577 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 409 5 1 6 3.9 COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL460683 183577 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 409 5 1 6 3.9 COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
54584234 67935 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 479 4 1 5 5.1 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 10.1016/j.bmc.2011.02.031
CHEMBL1765503 67935 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 479 4 1 5 5.1 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 10.1016/j.bmc.2011.02.031
CHEMBL2114443 216034 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
CHEMBL5291459 201311 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCO[C@@]23CC[C@@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1021/acs.jmedchem.1c00790
9851741 86968 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 604 7 1 2 8.0 C[C@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(F)cc2)CC[C@@]12C=Cc1ccccc12 10.1021/jm060439n
CHEMBL213601 86968 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 604 7 1 2 8.0 C[C@H]1CN(CC[C@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc(F)cc2)CC[C@@]12C=Cc1ccccc12 10.1021/jm060439n
CHEMBL2112242 216008 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
10456592 12071 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 453 4 1 3 6.1 Cc1cc(C)cc(CN(C)C(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 10.1021/jm00016a014
CHEMBL106609 12071 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 453 4 1 3 6.1 Cc1cc(C)cc(CN(C)C(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 10.1021/jm00016a014
56657842 70016 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Tested for binding affinity against Tachykinin receptor 1Tested for binding affinity against Tachykinin receptor 1
ChEMBL 839 7 6 7 4.2 C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)C2C(=O)[C@@H](Cc3c2[nH]c2ccccc32)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCC2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm000316h
CHEMBL1790897 70016 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Tested for binding affinity against Tachykinin receptor 1Tested for binding affinity against Tachykinin receptor 1
ChEMBL 839 7 6 7 4.2 C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccc(F)cc2)C2C(=O)[C@@H](Cc3c2[nH]c2ccccc32)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCC2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm000316h
44359260 122263 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 523 8 3 3 6.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)c(Cl)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL335106 122263 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 523 8 3 3 6.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(Cl)c(Cl)c1)c1ccccc1 10.1021/jm00022a010
10407571 174736 10 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL431690 174736 10 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
10047989 99272 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 424 7 2 5 4.4 COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00035a006
CHEMBL24314 99272 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 424 7 2 5 4.4 COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00035a006
56671766 73218 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 407 5 1 3 4.9 O=C1CCN(Cc2ccccc2O)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817828 73218 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 407 5 1 3 4.9 O=C1CCN(Cc2ccccc2O)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852010 73218 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 407 5 1 3 4.9 O=C1CCN(Cc2ccccc2O)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
44303835 108543 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 494 11 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 10.1016/S0960-894X(01)80747-2
CHEMBL299887 108543 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 494 11 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 10.1016/S0960-894X(01)80747-2
21256636 37000 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 503 8 1 4 5.4 COc1ccccc1C(CNC(=O)Cc1ccc(Cl)c(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139072 37000 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 503 8 1 4 5.4 COc1ccccc1C(CNC(=O)Cc1ccc(Cl)c(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
10047989 99272 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 424 7 2 5 4.4 COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00066a015
CHEMBL24314 99272 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 424 7 2 5 4.4 COc1ccccc1COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00066a015
CHEMBL216813 216120 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(N)=O 10.1021/jm00037a009
44321430 113763 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00092a009
CHEMBL315176 113763 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1cccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00092a009
10811257 108604 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL300303 108604 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44277705 108744 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 397 6 0 2 5.8 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL30139 108744 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 397 6 0 2 5.8 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
44306217 209821 0 None - 0 Guinea pig 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 538 8 3 4 3.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCC(O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL63471 209821 0 None - 0 Guinea pig 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 538 8 3 4 3.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCC(O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44334111 116584 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 513 6 1 3 7.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cccc3ccccc23)c1 10.1016/S0960-894X(96)00563-X
CHEMBL323317 116584 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 513 6 1 3 7.0 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cccc3ccccc23)c1 10.1016/S0960-894X(96)00563-X
CHEMBL2372521 217048 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1CCc2ccccc21)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
24801797 94202 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 476 6 0 5 4.8 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)C3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333627 94202 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 476 6 0 5 4.8 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)C3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
71541470 94210 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.5 C/C=C/c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333635 94210 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.5 C/C=C/c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
24801101 94217 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 402 5 1 3 4.7 Fc1ccc(C2(COCc3cc(C(F)(F)F)cc(Cl)n3)CCNCC2)cc1 10.1016/j.bmcl.2012.11.094
CHEMBL2333642 94217 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 402 5 1 3 4.7 Fc1ccc(C2(COCc3cc(C(F)(F)F)cc(Cl)n3)CCNCC2)cc1 10.1016/j.bmcl.2012.11.094
CHEMBL306072 217756 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
67233125 133221 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 564 4 1 3 5.8 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)Nc3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3651888 133221 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 564 4 1 3 5.8 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)Nc3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
71541575 94187 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 379 6 0 4 4.2 CN1CCC(COCc2cc(C#N)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333612 94187 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 379 6 0 4 4.2 CN1CCC(COCc2cc(C#N)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
44277705 108744 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
CHEMBL30139 108744 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 397 6 0 2 5.8 Cc1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
10649948 13460 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 532 9 2 3 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F 10.1021/jm970499g
CHEMBL108349 13460 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 532 9 2 3 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F 10.1021/jm970499g
18654560 119087 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 668 16 0 4 7.3 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2)C1 10.1016/S0960-894X(01)80747-2
CHEMBL329168 119087 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 668 16 0 4 7.3 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)Cc2ccccc2)C1 10.1016/S0960-894X(01)80747-2
44349003 24762 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 443 1 1 4 6.0 CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL126221 24762 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 443 1 1 4 6.0 CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
10350454 113508 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 113508 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44458353 106380 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL283979 106380 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(95)00205-8
10520658 105423 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1021/jm00024a007
CHEMBL277260 105423 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1021/jm00024a007
44337500 113966 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 604 9 2 4 6.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1cc2ccccc2s1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL316515 113966 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 604 9 2 4 6.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1cc2ccccc2s1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
44458328 106291 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL283356 106291 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 411 6 0 2 6.1 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
44286798 174211 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.6 CN(CC(c1ccccc1)c1ccccc1)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL42972 174211 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.6 CN(CC(c1ccccc1)c1ccccc1)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
10075002 11533 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 508 7 1 5 5.8 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc([N+](=O)[O-])cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL103851 11533 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 508 7 1 5 5.8 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc([N+](=O)[O-])cc2)c1 10.1016/S0960-894X(96)00563-X
10027219 106358 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 459 6 1 2 6.1 NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL283872 106358 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 459 6 1 2 6.1 NC(=O)C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
24799364 94195 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 467 9 1 4 6.0 CCC(CC)Nc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333620 94195 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 467 9 1 4 6.0 CCC(CC)Nc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
9910432 140301 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 428 4 2 2 5.6 FC(F)(F)c1cc(CNC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.026
CHEMBL370816 140301 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 428 4 2 2 5.6 FC(F)(F)c1cc(CNC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.026
22724580 146946 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 429 4 1 2 6.1 FC(F)(F)c1cc(COC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL380351 146946 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 429 4 1 2 6.1 FC(F)(F)c1cc(COC2CCC3CCC2(c2ccccc2)N3)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL5268460 200344 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomesInhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomes
ChEMBL 1278 40 16 16 -1.8 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)[C@H]1CCc2ccccc21)C(=O)N[C@@H](CCSC)C(=O)O 10.1021/acs.jmedchem.6b01029
CHEMBL5282996 200958 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomesInhibition of [125I]BHSP binding to neurokinin receptor 1 in rat brain synaptosomes
ChEMBL 1326 40 16 16 -0.7 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C1c2ccccc2-c2ccccc21)C(=O)N[C@@H](CCSC)C(=O)O 10.1021/acs.jmedchem.6b01029
44358719 36622 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 573 7 1 3 6.5 Cc1c(F)cccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138764 36622 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 573 7 1 3 6.5 Cc1c(F)cccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44358742 37737 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 657 7 0 3 8.4 CN(CC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL139854 37737 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 657 7 0 3 8.4 CN(CC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
10603097 63266 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 11 2 6 4.0 CC(=O)N(Cc1ccccc1[N+](=O)[O-])CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL163310 63266 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 11 2 6 4.0 CC(=O)N(Cc1ccccc1[N+](=O)[O-])CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
10674548 64217 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 11 3 5 3.9 CNC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165510 64217 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 11 3 5 3.9 CNC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44305544 209853 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 582 5 1 2 8.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL63785 209853 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 582 5 1 2 8.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
10457416 21658 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL120781 21658 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm9700171
10457416 21658 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL120781 21658 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 470 7 2 2 5.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
11225834 105985 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 502 4 0 2 7.5 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL281491 105985 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 502 4 0 2 7.5 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
10696382 128761 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 489 7 0 4 5.4 COC(=O)CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL359214 128761 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 489 7 0 4 5.4 COC(=O)CN1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL2115375 216045 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
56668399 73241 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(OC)c(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
CHEMBL1817886 73241 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(OC)c(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
CHEMBL1852139 73241 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(OC)c(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
10530699 126916 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 550 11 2 4 5.0 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CC=C(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351253 126916 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 550 11 2 4 5.0 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CC=C(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
9831309 142042 1 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1021/jm058225d
CHEMBL372587 142042 1 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against tachykinin receptor 1Inhibitory concentration against tachykinin receptor 1
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1021/jm058225d
153996 119445 2 None 3 3 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL330366 119445 2 None 3 3 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL539021 119445 2 None 3 3 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
153996 119445 2 None - 3 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL330366 119445 2 None - 3 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL539021 119445 2 None - 3 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44338583 12568 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 468 6 1 3 5.2 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F 10.1016/s0960-894x(02)00563-2
CHEMBL107875 12568 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 468 6 1 3 5.2 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F 10.1016/s0960-894x(02)00563-2
44338346 12643 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL107941 12643 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44338587 14211 3 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL108667 14211 3 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COC[C@H](c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
44359083 36172 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 473 8 3 3 5.4 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1F)c1ccccc1 10.1021/jm00022a010
CHEMBL138390 36172 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 473 8 3 3 5.4 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1F)c1ccccc1 10.1021/jm00022a010
57398781 77728 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 486 4 0 2 5.3 CC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
CHEMBL1951619 77728 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 486 4 0 2 5.3 CC(=O)N1CC[C@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.11.048
24888943 14719 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090438 14719 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 571 5 0 3 7.1 C[C@@H](O[C@H]1CN2C(=O)C=C(C3CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
52941489 24503 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258623 24503 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 516 4 1 3 5.2 C[C@@H](O[C@H]1CN2C(=O)C3CNCC3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
18709650 172026 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 501 11 3 5 4.0 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(O)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42295 172026 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 501 11 3 5 4.0 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(O)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
9888665 128759 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL359206 128759 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10721128 63060 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 537 10 2 4 4.4 CC(=O)N(Cc1ccccc1C)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL162977 63060 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 537 10 2 4 4.4 CC(=O)N(Cc1ccccc1C)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
10769745 64269 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 591 10 2 4 5.1 CC(=O)N(Cc1ccccc1C(F)(F)F)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165949 64269 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 591 10 2 4 5.1 CC(=O)N(Cc1ccccc1C(F)(F)F)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
132837 9018 55 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm9700171
9461 9018 55 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm9700171
CHEMBL22870 9018 55 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm9700171
44297434 201753 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 599 9 1 4 5.8 CS(=O)(=O)N1CC2(CCN(C(=O)C(CCCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54602 201753 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 599 9 1 4 5.8 CS(=O)(=O)N1CC2(CCN(C(=O)C(CCCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
132837 9018 55 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
9461 9018 55 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
CHEMBL22870 9018 55 None 18 5 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
44273822 82279 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 569 7 1 4 7.0 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCCCC3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL20430 82279 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 569 7 1 4 7.0 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCCCC3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL2372516 217044 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
44289862 107127 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 541 13 2 5 4.9 COc1ccc(C(=O)CCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
CHEMBL289600 107127 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 541 13 2 5 4.9 COc1ccc(C(=O)CCC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
21994258 126181 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 577 7 1 3 6.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL344646 126181 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 577 7 1 3 6.4 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(F)c(F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44328423 114148 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 5.7 COc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL317761 114148 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 5.7 COc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL426363 220124 0 None 26 3 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
104943 62160 39 None 1862 3 Human 8.5 pIC50 = 8.5 Binding
Binding potency against SP receptor (from ref. 1)Binding potency against SP receptor (from ref. 1)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
CHEMBL16192 62160 39 None 1862 3 Human 8.5 pIC50 = 8.5 Binding
Binding potency against SP receptor (from ref. 1)Binding potency against SP receptor (from ref. 1)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
58993517 128871 0 None - 0 Mongolian jird 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 469 8 1 3 6.6 CCOc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596480 128871 0 None - 0 Mongolian jird 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 469 8 1 3 6.6 CCOc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
44433794 174231 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ccncn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL429798 174231 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 536 5 0 4 5.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)c2ccncn2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
9927183 202384 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1016/j.bmcl.2007.10.010
CHEMBL55591 202384 0 None - 1 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cellsDisplacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1016/j.bmcl.2007.10.010
15214194 11887 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 552 4 0 3 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL105629 11887 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 552 4 0 3 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1C 10.1021/jm00016a014
10096063 115201 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 465 4 0 4 5.5 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(Cl)cc(Cl)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
CHEMBL319874 115201 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 465 4 0 4 5.5 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(Cl)cc(Cl)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
11757401 66720 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173231 66720 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
2089 9542 28 None - 5 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3795 9542 28 None - 5 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
5311311 9542 28 None - 5 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL217406 9542 28 None - 5 Guinea pig 8.5 pIC50 = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
44415513 172547 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 2 5.2 NC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL424709 172547 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 2 5.2 NC(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44306327 19806 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 595 11 2 6 3.2 CN(C)CCn1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
CHEMBL1189912 19806 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 595 11 2 6 3.2 CN(C)CCn1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
CHEMBL539762 19806 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 595 11 2 6 3.2 CN(C)CCn1cc(C(=O)N2C[C@H](O)CC2C(=O)N[C@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00039a022
44306196 107511 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 605 9 2 7 3.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL292715 107511 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 605 9 2 7 3.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44306107 109612 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 606 8 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(C(F)(F)F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL305547 109612 0 None - 0 Guinea pig 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 606 8 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(C(F)(F)F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
18709663 172881 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 527 12 2 5 4.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(C(C)=O)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL42597 172881 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 527 12 2 5 4.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)COc1ccc(C(C)=O)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
44370340 126325 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 640 17 3 5 5.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCNCC(N)=O)C1 10.1016/0960-894X(95)00080-D
CHEMBL345866 126325 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 640 17 3 5 5.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCNCC(N)=O)C1 10.1016/0960-894X(95)00080-D
19797460 127790 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.8 Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL356518 127790 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.8 Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44305467 109589 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 430 5 1 2 5.8 CN(C(=O)c1ccccc1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL305375 109589 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 430 5 1 2 5.8 CN(C(=O)c1ccccc1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
71720664 94213 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 383 5 1 2 5.2 FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333638 94213 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 383 5 1 2 5.2 FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
24784193 128872 0 None - 0 Mongolian jird 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 441 6 2 3 5.9 Oc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596481 128872 0 None - 0 Mongolian jird 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 441 6 2 3 5.9 Oc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
44456651 102225 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL257112 102225 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@@H]1[C@@H](c2ccccc2)CN(C(=O)OC(C)(C)C)[C@H]1CO)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
73348949 97597 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 minsDisplacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 mins
ChEMBL 494 5 1 2 6.0 Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2013.01.025
CHEMBL2392023 97597 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 minsDisplacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 mins
ChEMBL 494 5 1 2 6.0 Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2013.01.025
44335354 11706 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 629 7 2 4 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Cl)c(Cl)s1 10.1016/s0960-894x(01)00631-x
CHEMBL104708 11706 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 629 7 2 4 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Cl)c(Cl)s1 10.1016/s0960-894x(01)00631-x
71458131 86459 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2115343 86459 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
44276882 103000 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 550 8 1 3 7.3 O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1cccnc1 10.1016/0960-894X(95)00220-N
CHEMBL26086 103000 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 550 8 1 3 7.3 O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1cccnc1 10.1016/0960-894X(95)00220-N
71541687 94190 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.3 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(F)c2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333615 94190 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.3 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(F)c2)CC1 10.1016/j.bmcl.2012.11.094
57395687 75398 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 2 4 4.3 CCNC(=O)N1CC[C@@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917846 75398 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 2 4 4.3 CCNC(=O)N1CC[C@@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
44433790 96219 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL237100 96219 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)CC1 10.1016/j.bmcl.2007.08.028
11114226 211329 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 537 10 3 4 7.0 CC(C)C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
CHEMBL72895 211329 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of specific binding at tachykinin receptor 1Inhibition of specific binding at tachykinin receptor 1
ChEMBL 537 10 3 4 7.0 CC(C)C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OCc1cc2ccccc2o1)C(=O)N[C@@H](C)c1ccccc1 10.1021/jm010825z
10075851 66796 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 536 9 3 3 5.4 O=C(Cc1c[nH]cn1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173564 66796 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 536 9 3 3 5.4 O=C(Cc1c[nH]cn1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
104943 62160 39 None 1862 3 Human 8.4 pIC50 = 8.4 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
CHEMBL16192 62160 39 None 1862 3 Human 8.4 pIC50 = 8.4 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
58993461 128870 0 None - 0 Mongolian jird 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596479 128870 0 None - 0 Mongolian jird 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
44370449 126675 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 760 20 2 6 7.0 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL349113 126675 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 760 20 2 6 7.0 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCN(CC(N)=O)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
46884470 14766 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090652 14766 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 580 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cc[nH]c(=O)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
19098237 43895 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145265 43895 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
44319086 20484 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194977 20484 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553617 20484 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
25129135 179376 0 None -7 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
CHEMBL448998 179376 0 None -7 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
44334113 12038 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 548 7 1 4 5.9 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(=O)Nc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL106440 12038 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 548 7 1 4 5.9 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCN(CC(=O)Nc3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
44326281 213967 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.1 CC(N)(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL92524 213967 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.1 CC(N)(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
44459032 97662 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 393 6 1 3 4.4 CC(=O)N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23926 97662 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 393 6 1 3 4.4 CC(=O)N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44318413 212462 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2cccc(C(F)(F)F)c2)C3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL82220 212462 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2cccc(C(F)(F)F)c2)C3)cc1 10.1016/s0960-894x(02)00506-1
24783424 128864 0 None - 0 Mongolian jird 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 493 6 1 2 7.2 FC(F)(F)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596473 128864 0 None - 0 Mongolian jird 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 493 6 1 2 7.2 FC(F)(F)c1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
10476776 115337 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 5 0 4 4.5 COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL320231 115337 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 5 0 4 4.5 COc1ccccc1CN(C)C(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44288758 107888 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL295122 107888 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
107686 10152 41 None - 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
3522 10152 41 None - 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL131171 10152 41 None - 2 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
44344231 120293 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@H](C)c2ccccc2)c1 10.1016/S0960-894X(96)00623-3
CHEMBL332111 120293 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CCC(NCc3ccnc4ccccc34)CC2[C@H](C)c2ccccc2)c1 10.1016/S0960-894X(96)00623-3
44346159 21294 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2[C@H](C)c2ccccc2)c1 10.1021/jm9700171
CHEMBL120190 21294 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 477 6 1 3 6.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2[C@H](C)c2ccccc2)c1 10.1021/jm9700171
44177669 68035 0 None -52 4 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766205 68035 0 None -52 4 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
44319571 113817 1 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL315532 113817 1 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
44415437 86752 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 537 7 1 3 7.5 O=C(N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)OCc1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL212697 86752 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 537 7 1 3 7.5 O=C(N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)OCc1ccccc1 10.1016/j.bmcl.2006.06.035
19797420 43634 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145051 43634 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10553958 108146 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL297068 108146 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
9915428 180412 3 None - 0 Human 5.5 pIC50 = 5.5 Binding
Compound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter substrate P as radioligandCompound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter substrate P as radioligand
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
CHEMBL45340 180412 3 None - 0 Human 5.5 pIC50 = 5.5 Binding
Compound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter substrate P as radioligandCompound was tested for binding affinity towards NK1 binding sites in human lymphoma IM9 cells using [125I]Bolton-Hunter substrate P as radioligand
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
44287895 107984 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 579 7 1 5 6.5 COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL295845 107984 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 579 7 1 5 6.5 COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
44304123 207356 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 10.1016/S0960-894X(01)80747-2
CHEMBL59913 207356 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 10.1016/S0960-894X(01)80747-2
10405990 214903 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 356 5 0 2 4.9 COC(=O)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 10.1016/S0960-894X(01)80821-0
CHEMBL98011 214903 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 356 5 0 2 4.9 COC(=O)C1(Cc2ccccc2)CCc2ccc(Cc3ccccc3)cc21 10.1016/S0960-894X(01)80821-0
9915428 180412 3 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
CHEMBL45340 180412 3 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
44287409 165828 1 None - 0 Human 5.5 pIC50 = 5.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.9 O=C(CC(c1ccccc1)c1ccccc1)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL40969 165828 1 None - 0 Human 5.5 pIC50 = 5.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.9 O=C(CC(c1ccccc1)c1ccccc1)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
44287368 162000 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 4 0 1 6.5 CN(C(=O)C(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL40262 162000 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 4 0 1 6.5 CN(C(=O)C(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
44287461 169473 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 493 8 0 1 7.3 CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL41705 169473 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 493 8 0 1 7.3 CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44357469 168534 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL 1329 41 13 19 -1.6 CSCC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)Cc1noc([C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCN=C(N)N)n1 10.1021/jm990197+
CHEMBL413904 168534 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.Affinity for rat Tachykinin receptor 1 determined in displacement screening by using radioligand 3,4-[3H]-(L-Pro e2) SP.
ChEMBL 1329 41 13 19 -1.6 CSCC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)Cc1noc([C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCN=C(N)N)n1 10.1021/jm990197+
10367419 11176 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 469 6 1 3 6.6 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 10.1021/jm9700171
CHEMBL101420 11176 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SPBinding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
ChEMBL 469 6 1 3 6.6 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 10.1021/jm9700171
11661655 112578 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126961 112578 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@@H]1CC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
10480944 66666 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 496 6 1 3 6.2 C=CCC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
CHEMBL173013 66666 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 496 6 1 3 6.2 C=CCC1(Cc2c[nH]c3ccccc23)OC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
2089 9542 28 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
3795 9542 28 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
5311311 9542 28 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL217406 9542 28 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
44274341 88324 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 473 6 1 3 5.8 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccccc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21611 88324 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 473 6 1 3 5.8 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccccc23)CC1 10.1016/s0960-894x(01)00182-2
56681830 73236 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
CHEMBL1817830 73236 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
CHEMBL1852124 73236 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1 10.1016/j.bmc.2011.07.014
10841047 64244 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 583 13 2 7 3.7 COC(=O)CN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165727 64244 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 583 13 2 7 3.7 COC(=O)CN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
9918576 214116 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against neurokinin NK1 receptorInhibitory concentration against neurokinin NK1 receptor
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1021/jm058225d
CHEMBL93556 214116 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against neurokinin NK1 receptorInhibitory concentration against neurokinin NK1 receptor
ChEMBL 764 14 0 10 7.0 COc1ccc(C2(CCN3CCC(C(=O)c4nc5ccccc5n4Cc4ccc(F)cc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1021/jm058225d
CHEMBL2370873 216717 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCC(=O)N1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCSC)C(N)=O 10.1016/S0960-894X(01)80229-8
44322406 171913 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 514 5 1 3 6.2 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL422773 171913 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 514 5 1 3 6.2 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(Cl)c(Cl)c1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44322515 213495 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 476 6 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL89818 213495 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 476 6 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
10367419 11176 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 469 6 1 3 6.6 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL101420 11176 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 469 6 1 3 6.6 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2CC2CCCCC2)c1 10.1016/S0960-894X(96)00563-X
10460069 173117 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 545 6 1 2 6.8 O=C1C(Cc2c[nH]c3ccccc23)N(Cc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL427295 173117 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 545 6 1 2 6.8 O=C1C(Cc2c[nH]c3ccccc23)N(Cc2ccccc2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
44383815 67075 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 462 7 1 3 5.7 COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/S0960-894X(00)80693-9
CHEMBL174365 67075 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 462 7 1 3 5.7 COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/S0960-894X(00)80693-9
12736776 17928 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 410 5 0 3 5.9 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 10.1021/jm00085a015
53641783 17928 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 410 5 0 3 5.9 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 10.1021/jm00085a015
CHEMBL1178362 17928 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 410 5 0 3 5.9 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 10.1021/jm00085a015
CHEMBL23360 17928 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 410 5 0 3 5.9 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Oc2ccccc21 10.1021/jm00085a015
44459024 17933 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 484 2 0 2 7.9 CCn1c2[n+](c3cc4ccccc4cc31)C(C)CC2=C/C=C1\N(C)c2ccc3ccccc3c2C1(C)C 10.1021/jm00085a015
CHEMBL1178380 17933 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 484 2 0 2 7.9 CCn1c2[n+](c3cc4ccccc4cc31)C(C)CC2=C/C=C1\N(C)c2ccc3ccccc3c2C1(C)C 10.1021/jm00085a015
CHEMBL24818 17933 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 484 2 0 2 7.9 CCn1c2[n+](c3cc4ccccc4cc31)C(C)CC2=C/C=C1\N(C)c2ccc3ccccc3c2C1(C)C 10.1021/jm00085a015
16755254 192953 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 515 4 1 5 5.9 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
CHEMBL487259 192953 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 515 4 1 5 5.9 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2nnnc12 10.1016/j.bmc.2008.05.067
44386230 68137 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 735 8 1 4 7.2 COc1c(Br)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1Br 10.1016/0960-894X(96)00148-5
CHEMBL176811 68137 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 735 8 1 4 7.2 COc1c(Br)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1Br 10.1016/0960-894X(96)00148-5
10350528 113510 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 113510 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for binding affinity against rat NK-1 receptorTested for binding affinity against rat NK-1 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44322511 113877 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 464 5 1 3 5.0 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
CHEMBL315937 113877 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 464 5 1 3 5.0 O=C(COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1016/s0960-894x(01)00727-2
44346557 120297 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 9 4 3 5.7 O=C(Cc1ccccc1)N[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL332139 120297 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 572 9 4 3 5.7 O=C(Cc1ccccc1)N[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
15295990 138885 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 455 4 2 2 4.9 O=C1NC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL369580 138885 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 455 4 2 2 4.9 O=C1NC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a011
54587143 67924 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 468 4 0 2 5.6 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] 10.1016/j.bmc.2011.02.031
CHEMBL1765494 67924 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 468 4 0 2 5.6 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] 10.1016/j.bmc.2011.02.031
11547090 95009 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 459 6 0 2 6.7 CCN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347856 95009 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 459 6 0 2 6.7 CCN1CCC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
44306398 210327 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 527 11 2 4 3.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCCc1ccccc1 10.1021/jm00039a022
CHEMBL66592 210327 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 527 11 2 4 3.4 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)CCCc1ccccc1 10.1021/jm00039a022
10432488 11668 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 424 4 0 3 5.4 Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccccc3C)c3ccccc3c(=O)n2C)c1 10.1021/jm00016a014
CHEMBL104513 11668 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 424 4 0 3 5.4 Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccccc3C)c3ccccc3c(=O)n2C)c1 10.1021/jm00016a014
10026002 116461 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 435 4 0 4 4.7 CN(Cc1ccccc1Cl)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
CHEMBL322714 116461 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 435 4 0 4 4.7 CN(Cc1ccccc1Cl)C(=O)c1c(-c2ccc(F)cc2)c2cccnc2c(=O)n1C 10.1021/jm00016a014
44358442 36579 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 569 8 0 3 6.3 CN(CC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL138727 36579 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 569 8 0 3 6.3 CN(CC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
107686 10152 41 None -15 2 Guinea pig 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
3522 10152 41 None -15 2 Guinea pig 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL131171 10152 41 None -15 2 Guinea pig 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in guinea pig brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
104943 62160 39 None - 3 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 62160 39 None - 3 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
2089 9542 28 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
3795 9542 28 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
5311311 9542 28 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
CHEMBL217406 9542 28 None - 5 Rat 7.5 pIC50 = 7.5 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
CHEMBL263185 217340 5 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O 10.1021/jm070577s
44270482 18754 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 499 10 1 4 5.2 CCOC(=O)C[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1183073 18754 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 499 10 1 4 5.2 CCOC(=O)C[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL278455 18754 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 499 10 1 4 5.2 CCOC(=O)C[N+]12CCC(CC1)[C@H](NCc1ccccc1OC)[C@@H]2C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
12736777 17927 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 426 5 0 3 6.6 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 10.1021/jm00085a015
54433543 17927 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 426 5 0 3 6.6 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 10.1021/jm00085a015
CHEMBL1178360 17927 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 426 5 0 3 6.6 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 10.1021/jm00085a015
CHEMBL23287 17927 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 426 5 0 3 6.6 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)Sc2ccccc21 10.1021/jm00085a015
44348666 120269 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 453 1 1 4 5.6 C#CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL331978 120269 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 453 1 1 4 5.6 C#CC[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44348801 120245 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 489 0 1 4 6.4 C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nc7cc8ccccc8cc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL331934 120245 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 489 0 1 4 6.4 C#C[C@]1(O)CCC2C3CC[C@H]4Cc5nc6nc7cc8ccccc8cc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44337421 115305 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Cl 10.1021/jm970499g
CHEMBL320029 115305 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1Cl 10.1021/jm970499g
44287388 162786 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 7 0 1 6.9 CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL40620 162786 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 7 0 1 6.9 CN(CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44297492 200471 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 576 10 1 6 3.8 CN(C)c1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 10.1016/s0960-894x(98)00320-5
CHEMBL52717 200471 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 576 10 1 6 3.8 CN(C)c1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 10.1016/s0960-894x(98)00320-5
131871 126306 6 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL345711 126306 6 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44306416 107358 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 468 9 3 3 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL291634 107358 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 468 9 3 3 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44370769 56791 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 507 12 1 3 6.3 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
CHEMBL156933 56791 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 507 12 1 3 6.3 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/0960-894X(95)00080-D
19797413 43632 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 419 6 0 2 5.8 Fc1cc(F)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145050 43632 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 419 6 0 2 5.8 Fc1cc(F)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10552574 126757 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 476 10 2 4 3.7 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCCCC1)C(C)=O 10.1021/jm950616c
CHEMBL349882 126757 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 476 10 2 4 3.7 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCCCC1)C(C)=O 10.1021/jm950616c
44359259 31892 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1Cl)c1ccccc1 10.1021/jm00022a010
CHEMBL134737 31892 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1Cl)c1ccccc1 10.1021/jm00022a010
44275987 106120 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL282331 106120 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
9892852 91155 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL22194 91155 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
44297939 108453 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 510 9 1 3 6.4 Cc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL299312 108453 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 510 9 1 3 6.4 Cc1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
71699788 131559 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1 nan
CHEMBL3642158 131559 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1 nan
44289256 107307 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 449 7 1 3 5.2 O=C(Cc1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL291298 107307 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 449 7 1 3 5.2 O=C(Cc1ccccc1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
44270549 17911 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 503 9 1 2 6.8 COc1ccccc1CN[C@H]1C2CC[N+](Cc3ccccc3)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL1178214 17911 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 503 9 1 2 6.8 COc1ccccc1CN[C@H]1C2CC[N+](Cc3ccccc3)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
CHEMBL15970 17911 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cellsCompound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
ChEMBL 503 9 1 2 6.8 COc1ccccc1CN[C@H]1C2CC[N+](Cc3ccccc3)(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80246-8
44312145 211495 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 7 3 2 5.1 O=C(NCCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL74176 211495 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 7 3 2 5.1 O=C(NCCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
10793140 64189 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 10 1 5 5.0 COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(C)=O 10.1021/jm950616c
CHEMBL165308 64189 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 568 10 1 5 5.0 COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(C)=O 10.1021/jm950616c
44297604 108413 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL299016 108413 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 635 9 1 5 5.7 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44276732 106781 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 565 8 2 3 7.1 O=C(NCc1cccnc1)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL286747 106781 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 565 8 2 3 7.1 O=C(NCc1cccnc1)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
24801102 94222 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 350 5 1 3 4.2 Clc1cc(COCC2(c3ccccc3)CCNCC2)cc(Cl)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333647 94222 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 350 5 1 3 4.2 Clc1cc(COCC2(c3ccccc3)CCNCC2)cc(Cl)n1 10.1016/j.bmcl.2012.11.094
46884468 14764 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 578 5 0 3 7.5 Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL1090650 14764 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 578 5 0 3 7.5 Cc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
44289441 107885 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 511 12 2 4 4.9 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccccc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL295107 107885 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 511 12 2 4 4.9 COc1ccccc1CN(C[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccccc1)C(C)=O 10.1016/s0960-894x(01)00250-5
10453364 12172 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 396 4 0 3 4.8 Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
CHEMBL107145 12172 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 396 4 0 3 4.8 Cc1ccccc1-c1c(C(=O)N(C)Cc2ccccc2)n(C)c(=O)c2ccccc12 10.1021/jm00016a014
10433381 12356 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 440 6 0 4 5.2 CCN(Cc1ccccc1OC)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL107689 12356 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 440 6 0 4 5.2 CCN(Cc1ccccc1OC)C(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
10350528 113510 0 None 251 3 Human 7.5 pIC50 = 7.5 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 113510 0 None 251 3 Human 7.5 pIC50 = 7.5 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44305511 209745 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 566 5 1 2 7.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL63014 209745 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 566 5 1 2 7.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
9823811 66689 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 426 7 1 3 5.5 COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
CHEMBL173110 66689 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 426 7 1 3 5.5 COc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
44358814 37866 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(Cl)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL139977 37866 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 489 8 3 3 5.9 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(Cl)c1)c1ccccc1 10.1021/jm00022a010
44352062 25706 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL128586 25706 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
131954513 168857 38 None - 1 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting methodDisplacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting method
ChEMBL 357 2 0 4 4.3 COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F 10.1021/acsmedchemlett.7b00317
CHEMBL4160748 168857 38 None - 1 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting methodDisplacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting method
ChEMBL 357 2 0 4 4.3 COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F 10.1021/acsmedchemlett.7b00317
21121353 108250 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for the binding affinity against rat neurokinin-1 (NK-1) receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for the binding affinity against rat neurokinin-1 (NK-1) receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 108250 0 None - 3 Rat 5.5 pIC50 = 5.5 Binding
Tested for the binding affinity against rat neurokinin-1 (NK-1) receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for the binding affinity against rat neurokinin-1 (NK-1) receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
54587142 67923 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 454 4 1 2 5.3 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] 10.1016/j.bmc.2011.02.031
CHEMBL1765493 67923 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 454 4 1 2 5.3 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc[n+]1[O-] 10.1016/j.bmc.2011.02.031
44321519 213507 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
CHEMBL89897 213507 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00092a009
44321519 213507 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL89897 213507 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 412 7 1 3 5.1 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
44307089 209792 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 445 4 0 2 6.0 CC(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL63278 209792 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 445 4 0 2 6.0 CC(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL2112244 216010 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cn2ccc3ccccc32)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
76318226 112575 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 501 6 0 3 6.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126958 112575 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 501 6 0 3 6.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
44294338 18821 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 10.1021/jm00109a034
54307293 18821 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183499 18821 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL300854 18821 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 454 6 1 5 4.6 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCO)c2nc3ccccc3nc21 10.1021/jm00109a034
11568372 212804 5 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL85047 212804 5 None - 0 Human 6.5 pIC50 = 6.5 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 403 4 1 2 5.7 FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
44380745 127076 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
CHEMBL352697 127076 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
10245452 107965 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL 320 4 1 2 3.1 O=C1C(Cc2c[nH]c3ccccc23)OCCN1Cc1ccccc1 10.1016/0960-894X(95)00582-E
CHEMBL295680 107965 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL 320 4 1 2 3.1 O=C1C(Cc2c[nH]c3ccccc23)OCCN1Cc1ccccc1 10.1016/0960-894X(95)00582-E
9888665 128759 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL359206 128759 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 425 7 0 2 6.3 Cc1cc(C)cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
10506928 126996 0 None 39 2 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL352102 126996 0 None 39 2 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44297498 108779 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL301630 108779 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccccc3Cl)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10552836 10959 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 0 3 7.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL100141 10959 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 483 6 0 3 7.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
58993657 128845 0 None - 0 Mongolian jird 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.7 Cn1nnc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2015.04.098
CHEMBL3596454 128845 0 None - 0 Mongolian jird 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.7 Cn1nnc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)n1 10.1016/j.bmcl.2015.04.098
16755228 180483 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 526 4 0 2 8.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cccc12 10.1016/j.bmc.2008.05.067
CHEMBL453581 180483 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 526 4 0 2 8.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cccc12 10.1016/j.bmc.2008.05.067
19797456 41243 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1ccc(C)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL142855 41243 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 411 6 0 2 6.1 Cc1ccc(C)c(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44319249 212851 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 631 12 1 8 4.4 COc1ccc(C2(CCN3CCC(C(N)=O)(c4ccccc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10013-0
CHEMBL85499 212851 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 631 12 1 8 4.4 COc1ccc(C2(CCN3CCC(C(N)=O)(c4ccccc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10013-0
44304176 209598 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL62357 209598 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
15154442 20938 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 436 5 0 2 6.8 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00085a015
53703341 20938 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 436 5 0 2 6.8 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00085a015
CHEMBL1198573 20938 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 436 5 0 2 6.8 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00085a015
CHEMBL23147 20938 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 436 5 0 2 6.8 CCN1/C(=C\C=C\c2n(CC)c3cc4ccccc4cc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00085a015
10071902 116179 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 439 5 1 3 5.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)CCc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL321979 116179 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 439 5 1 3 5.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)CCc3ccccc3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL2369630 216424 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligandTested for binding affinity against Q165A mutant NK1 receptor expressed in CHO cells, using [125]SP as radioligand
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44346480 121640 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 317 7 1 2 4.4 N[C@H](COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL334189 121640 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 317 7 1 2 4.4 N[C@H](COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL2369767 216463 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/0960-894X(94)85022-4
44299298 203028 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 317 7 1 2 4.4 NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL56176 203028 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 317 7 1 2 4.4 NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
15037918 51628 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 400 6 1 2 5.2 Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL152239 51628 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 400 6 1 2 5.2 Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
19797436 43611 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 461 6 0 2 6.3 Brc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL145030 43611 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 461 6 0 2 6.3 Brc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
19797448 44016 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL145360 44016 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44358500 38286 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 539 9 0 8 4.2 COc1cc(C(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)cc(OC)c1OC 10.1021/jm000986n
CHEMBL140360 38286 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 539 9 0 8 4.2 COc1cc(C(=O)N(C)CC(c2cccc3c2OCO3)N2CCC(N3CCCCC3)CC2)cc(OC)c1OC 10.1021/jm000986n
44287861 168518 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 472 5 1 4 4.4 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL41375 168518 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 472 5 1 4 4.4 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
19797446 41319 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL142919 41319 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
10793492 118079 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 587 10 4 3 4.7 O=C(NCCc1c[nH]c2ccccc12)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL326649 118079 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 587 10 4 3 4.7 O=C(NCCc1c[nH]c2ccccc12)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
44358426 37658 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 595 6 0 3 7.3 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139753 37658 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 595 6 0 3 7.3 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCCCC1C(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10336036 119123 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 318 4 1 1 3.8 O=C(Cc1c[nH]c2ccccc12)N1CCC(Cc2ccccc2)C1 10.1016/S0960-894X(96)00570-7
CHEMBL32940 119123 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 318 4 1 1 3.8 O=C(Cc1c[nH]c2ccccc12)N1CCC(Cc2ccccc2)C1 10.1016/S0960-894X(96)00570-7
44359055 39106 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 584 10 4 5 6.3 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(CNC(=O)OC(C)(C)C)cc1)c1ccccc1 10.1021/jm00022a010
CHEMBL141050 39106 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 584 10 4 5 6.3 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(CNC(=O)OC(C)(C)C)cc1)c1ccccc1 10.1021/jm00022a010
10501444 108654 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL300722 108654 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44287555 165579 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL40944 165579 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
23294214 175939 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 590 7 1 4 6.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL440465 175939 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 590 7 1 4 6.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
76332769 112584 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 487 8 0 2 7.5 CCN(CC)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126967 112584 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 487 8 0 2 7.5 CCN(CC)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
10646925 37756 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 407 5 1 2 4.1 Ic1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL139868 37756 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 407 5 1 2 4.1 Ic1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
44287895 107984 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 579 7 1 5 6.5 COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL295845 107984 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 579 7 1 5 6.5 COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)[C@@](O)(c1ccccc1OC)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
16755230 179754 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 527 4 0 3 7.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2ccnc12 10.1016/j.bmc.2008.05.067
CHEMBL451773 179754 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 527 4 0 3 7.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2ccnc12 10.1016/j.bmc.2008.05.067
24801459 94206 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 389 5 0 4 4.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C#N)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333631 94206 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 389 5 0 4 4.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C#N)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
15755301 107847 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 630 15 4 7 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL294814 107847 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 630 15 4 7 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44345010 21252 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2/CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL120126 21252 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2/CC[C@H](NC(=O)c3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
10041813 103729 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 322 7 2 3 3.4 CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00035a006
CHEMBL26623 103729 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 322 7 2 3 3.4 CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00035a006
10041813 103729 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 322 7 2 3 3.4 CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00066a015
CHEMBL26623 103729 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 322 7 2 3 3.4 CCN[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00066a015
44297822 201803 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 12 2 5 4.8 CS(=O)(=O)NCC1(c2ccccc2)CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL54931 201803 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 12 2 5 4.8 CS(=O)(=O)NCC1(c2ccccc2)CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
44321099 213004 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 426 7 0 3 5.4 COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL86659 213004 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 426 7 0 3 5.4 COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
15755334 103337 0 None - 0 Guinea pig 4.4 pIC50 = 4.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 578 13 6 6 1.6 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a011
CHEMBL263013 103337 0 None - 0 Guinea pig 4.4 pIC50 = 4.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 578 13 6 6 1.6 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a011
44177670 68036 0 None -190 4 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766206 68036 0 None -190 4 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
71541471 94211 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 436 6 0 3 5.8 CC(C)=Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333636 94211 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 436 6 0 3 5.8 CC(C)=Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
71452815 86487 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
CHEMBL2115528 86487 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
44328405 112975 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 456 6 1 2 6.4 Clc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL313863 112975 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 456 6 1 2 6.4 Clc1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44338646 15927 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 474 7 1 3 6.0 CC(C)c1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL110086 15927 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 474 7 1 3 6.0 CC(C)c1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
10552836 10959 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 0 3 7.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL100141 10959 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 483 6 0 3 7.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3ccco3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
10576866 118268 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 485 6 1 5 5.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL327736 118268 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 485 6 1 5 5.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44294398 18015 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 438 5 0 4 5.6 CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00109a034
54220048 18015 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 438 5 0 4 5.6 CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00109a034
CHEMBL1178902 18015 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 438 5 0 4 5.6 CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00109a034
CHEMBL48734 18015 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 438 5 0 4 5.6 CCN1/C(=C/C=C/c2n(CC)c3nc4ccccc4nc3[n+]2CC)C(C)(C)c2ccccc21 10.1021/jm00109a034
16755206 193418 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 512 4 1 2 7.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cccc12 10.1016/j.bmc.2008.05.067
CHEMBL488045 193418 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 512 4 1 2 7.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cccc12 10.1016/j.bmc.2008.05.067
44303938 209927 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 713 16 5 10 3.0 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL64166 209927 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 713 16 5 10 3.0 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
15154438 17932 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 422 4 0 2 6.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
53968534 17932 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 422 4 0 2 6.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL1178371 17932 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 422 4 0 2 6.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL23682 17932 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 422 4 0 2 6.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2cc3ccccc3cc21 10.1021/jm00085a015
44288936 164947 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 517 6 0 3 6.9 CN(Cc1ccnc2ccccc12)[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL40875 164947 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 517 6 0 3 6.9 CN(Cc1ccnc2ccccc12)[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
11409185 106199 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding componentInhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding component
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
CHEMBL282853 106199 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding componentInhibition of labeled SP total binding against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells by the second binding component
ChEMBL 488 4 1 2 7.2 Cc1nc2ccccc2c(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm034219a
44287390 162552 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.3 O=C(NCC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL40587 162552 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.3 O=C(NCC(c1ccccc1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
44338557 16120 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 330 6 1 3 3.5 Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
CHEMBL111244 16120 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 330 6 1 3 3.5 Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00563-2
132837 9018 55 None 18 5 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
9461 9018 55 None 18 5 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
CHEMBL22870 9018 55 None 18 5 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
132837 9018 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
9461 9018 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
CHEMBL22870 9018 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
132837 9018 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
9461 9018 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
CHEMBL22870 9018 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
132837 9018 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
9461 9018 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
CHEMBL22870 9018 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
132837 9018 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
9461 9018 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
CHEMBL22870 9018 55 None -18 5 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
11757401 66720 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL173231 66720 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 555 9 2 4 4.8 O=C(CN1CCOCC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
56671913 73242 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 439 6 0 3 5.3 COc1ccc(F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817888 73242 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 439 6 0 3 5.3 COc1ccc(F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852140 73242 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 439 6 0 3 5.3 COc1ccc(F)cc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
46884473 14561 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 565 5 0 4 6.6 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089397 14561 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 565 5 0 4 6.6 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cncnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10817203 64304 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 589 12 2 6 3.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)S(C)(=O)=O 10.1021/jm950616c
CHEMBL166240 64304 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 589 12 2 6 3.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)S(C)(=O)=O 10.1021/jm950616c
44305271 109021 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 528 4 0 2 7.0 CN(C)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL303119 109021 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 528 4 0 2 7.0 CN(C)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
44319323 20519 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1195230 20519 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL554092 20519 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL394671 219257 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
CHEMBL394671 219257 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O 10.1021/jm070577s
44433788 95308 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 5 1 3 4.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCNCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL235220 95308 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 541 5 1 3 4.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(C(=O)C2CCNCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
44328425 176250 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 6.0 COc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL442962 176250 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 452 7 1 3 6.0 COc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44233184 201547 0 None 12 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL538131 201547 0 None 12 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
9871754 12181 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL107172 12181 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
104943 62160 39 None 1862 3 Human 8.4 pIC50 = 8.4 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
CHEMBL16192 62160 39 None 1862 3 Human 8.4 pIC50 = 8.4 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
44410162 83904 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 443 4 1 2 6.6 C[C@@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL207698 83904 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 443 4 1 2 6.6 C[C@@H](OC1CCC2CCC1(c1ccccc1)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
44294261 86408 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 593 7 0 2 9.1 Fc1ccc(C2CCN([C@H]3CC[C@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2115010 86408 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 593 7 0 2 9.1 Fc1ccc(C2CCN([C@H]3CC[C@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
10086982 122970 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 314 6 3 4 2.0 O=C(N[C@@H](Cc1ccccc1)C(=O)NO)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358422 122970 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 314 6 3 4 2.0 O=C(N[C@@H](Cc1ccccc1)C(=O)NO)OCc1ccccc1 10.1021/ml5002954
10072926 116463 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 459 4 1 3 6.1 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3Cl)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL322718 116463 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 459 4 1 3 6.1 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3ccccc3Cl)n(C)c(=O)c2cc1C 10.1021/jm00016a014
9871754 12181 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
CHEMBL107172 12181 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm990220r
134138503 161219 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL 694 13 6 7 2.8 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N/N=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acsmedchemlett.6b00381
CHEMBL3932836 161219 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL 694 13 6 7 2.8 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N/N=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acsmedchemlett.6b00381
CHEMBL3990081 161219 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysisDisplacement of [Leu-3,4,5-3H(N)]-Substance P from NK1 receptor in rat brain homogenate measured after 60 mins by microbeta scintillation counting analysis
ChEMBL 694 13 6 7 2.8 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N/N=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acsmedchemlett.6b00381
49863734 22105 0 None 13 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214027 22105 0 None 13 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
44326362 214076 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.5 CC(OCC(N)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00476-A
CHEMBL93243 214076 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.5 CC(OCC(N)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00476-A
16755231 195771 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 527 4 0 3 7.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cncc12 10.1016/j.bmc.2008.05.067
CHEMBL508659 195771 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 527 4 0 3 7.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cncc12 10.1016/j.bmc.2008.05.067
44306219 109506 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL304901 109506 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44358703 122842 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 625 7 0 4 7.3 COc1ccccc1C(C1CCCCN1C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL335624 122842 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 625 7 0 4 7.3 COc1ccccc1C(C1CCCCN1C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
9853506 19861 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1190281 19861 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL540553 19861 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
9799676 202598 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COCC(C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
CHEMBL55823 202598 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COCC(C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
44456748 175959 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL440587 175959 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 551 5 1 4 6.7 C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
10071073 12123 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 425 4 0 4 4.8 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C)cc(C)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
CHEMBL106904 12123 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 425 4 0 4 4.8 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C)cc(C)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
44233410 202373 0 None 38 3 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 28 14 16 1.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL555504 202373 0 None 38 3 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 28 14 16 1.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
44433789 152912 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL391963 152912 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 583 5 0 3 5.2 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccccc3)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2007.08.028
10792813 64290 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 552 11 2 4 5.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL166144 64290 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 552 11 2 4 5.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44319224 113853 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315814 113853 0 None - 0 Guinea pig 8.4 pIC50 = 8.4 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
10360490 95514 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.8 Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL23617 95514 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.8 Clc1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL238168 217170 7 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)C(N)=O 10.1021/jm070577s
10007035 86300 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 524 8 3 4 3.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@H](O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL2114031 86300 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 524 8 3 4 3.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@H](O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
10460415 123317 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 559 7 1 3 6.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL336261 123317 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 559 7 1 3 6.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cccc(F)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
10745307 172185 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1cccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)c1 10.1021/jm950616c
CHEMBL423824 172185 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 553 11 2 5 4.1 COc1cccc(CN(CC(Cc2c[nH]c3ccccc23)NC(=O)CN2CCN(c3ccccc3)CC2)C(C)=O)c1 10.1021/jm950616c
CHEMBL238168 217170 7 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Displacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [125I]Lys3-substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)C(N)=O 10.1021/jm070577s
11547594 112593 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 485 6 0 2 7.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126975 112593 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 485 6 0 2 7.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
136043853 145693 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 528 8 2 5 5.8 CN(Cc1n[nH]c(O)n1)C[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL378340 145693 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 528 8 2 5 5.8 CN(Cc1n[nH]c(O)n1)C[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
58993634 128878 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 522 6 1 3 6.6 N#Cc1c(F)c(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c(F)c1F 10.1016/j.bmcl.2015.04.098
CHEMBL3596487 128878 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 522 6 1 3 6.6 N#Cc1c(F)c(F)c(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c(F)c1F 10.1016/j.bmcl.2015.04.098
10438407 107430 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 590 11 2 6 4.4 CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL292190 107430 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 590 11 2 6 4.4 CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
57395686 78392 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 408 7 1 4 4.6 CCN1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1917841 78392 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 408 7 1 4 4.6 CCN1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
CHEMBL1963411 78392 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 408 7 1 4 4.6 CCN1CC[C@H](NCc2cc(OC(F)(F)F)ccc2OC)[C@H](c2ccccc2)C1 10.1016/j.bmc.2011.08.070
53249015 67932 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 550 5 0 4 6.1 Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765500 67932 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 550 5 0 4 6.1 Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
9939040 11782 7 None 2 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
CHEMBL105060 11782 7 None 2 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
44358864 37119 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1ccc2c(c1)OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL139176 37119 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 599 7 0 5 6.1 CN(CC(c1ccc2c(c1)OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
44319306 113874 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315923 113874 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44274183 89239 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)ccc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21760 89239 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)ccc23)CC1 10.1016/s0960-894x(01)00182-2
56661423 73228 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccccc2C(F)(F)F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817832 73228 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccccc2C(F)(F)F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852069 73228 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 459 5 0 2 6.2 O=C1CCN(Cc2ccccc2C(F)(F)F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
136043849 145478 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 542 9 2 5 6.1 CN(CC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)Cc1n[nH]c(O)n1 10.1016/j.bmcl.2006.06.035
CHEMBL377916 145478 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 542 9 2 5 6.1 CN(CC[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)Cc1n[nH]c(O)n1 10.1016/j.bmcl.2006.06.035
44306108 109613 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 606 8 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL305548 109613 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 606 8 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
22293578 193906 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 591 7 0 1 9.9 Fc1ccc(C2CCN(C3CCC(CCCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL49175 193906 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 591 7 0 1 9.9 Fc1ccc(C2CCN(C3CCC(CCCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
44415424 148233 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 537 7 1 3 7.5 O=C(N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)OCc1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL384244 148233 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 537 7 1 3 7.5 O=C(N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1)OCc1ccccc1 10.1016/j.bmcl.2006.06.035
11498370 107953 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL295615 107953 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 1 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
15295987 138130 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 2 2 4.3 O=C1NC(Cc2c[nH]c3ccccc23)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
CHEMBL368804 138130 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 2 2 4.3 O=C1NC(Cc2c[nH]c3ccccc23)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm00006a011
CHEMBL5283681 201003 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsDisplacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cells
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCO[C@]23CC[C@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1021/acs.jmedchem.1c00790
15755316 209672 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 703 16 4 9 3.7 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC1CCCCC1 10.1021/jm00089a011
CHEMBL62711 209672 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 703 16 4 9 3.7 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCC1CCCCC1 10.1021/jm00089a011
44299298 203028 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 317 7 1 2 4.4 NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
CHEMBL56176 203028 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 317 7 1 2 4.4 NC(COCc1ccccc1)C(c1ccccc1)c1ccccc1 10.1021/jm0311487
16755256 179878 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 529 4 1 5 6.2 Cc1ccc(-c2c(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 10.1016/j.bmc.2008.05.067
CHEMBL452027 179878 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 529 4 1 5 6.2 Cc1ccc(-c2c(C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 10.1016/j.bmc.2008.05.067
CHEMBL2369599 216412 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC1=O 10.1021/jm960281e
14986135 170180 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL419500 170180 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
44287606 107287 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 470 5 0 4 4.6 CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL291146 107287 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 470 5 0 4 4.6 CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
10228092 84080 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 487 6 1 4 5.4 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cnccc21 10.1016/s0960-894x(01)00182-2
CHEMBL20826 84080 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 487 6 1 4 5.4 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cnccc21 10.1016/s0960-894x(01)00182-2
58993510 128832 0 None - 0 Mongolian jird 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 426 6 1 3 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccn2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596200 128832 0 None - 0 Mongolian jird 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 426 6 1 3 5.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccn2)c1 10.1016/j.bmcl.2015.04.098
54580277 67934 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 466 4 0 2 6.7 Cc1cc(-c2ccccc2)c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 10.1016/j.bmc.2011.02.031
CHEMBL1765502 67934 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 466 4 0 2 6.7 Cc1cc(-c2ccccc2)c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 10.1016/j.bmc.2011.02.031
9830535 213595 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 620 17 1 4 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL90416 213595 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 620 17 1 4 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/S0960-894X(01)80747-2
9830535 213595 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 620 17 1 4 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
CHEMBL90416 213595 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 620 17 1 4 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
44294324 19134 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 496 7 0 6 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
54414362 19134 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 496 7 0 6 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1185473 19134 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 496 7 0 6 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL416468 19134 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 496 7 0 6 5.2 CCn1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)[n+](CCCOC(C)=O)c2nc3ccccc3nc21 10.1021/jm00109a034
71583095 94994 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347693 94994 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 6.0 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCCNC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
71699791 131562 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 591 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642161 131562 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 591 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
44337667 115634 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 568 9 3 5 4.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL321021 115634 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 568 9 3 5 4.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
10744740 116440 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 528 9 2 3 4.6 Cc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL322508 116440 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 528 9 2 3 4.6 Cc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
15154446 17924 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 480 6 0 4 6.0 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 10.1021/jm00085a015
53746881 17924 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 480 6 0 4 6.0 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL1178355 17924 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 480 6 0 4 6.0 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL23073 17924 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 480 6 0 4 6.0 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCOC(C)=O)c2cc3ccccc3cc21 10.1021/jm00085a015
10318477 174089 40 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 394 6 2 4 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00035a006
CHEMBL429395 174089 40 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 394 6 2 4 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00035a006
10318477 174089 40 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 394 6 2 4 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00066a015
CHEMBL429395 174089 40 None - 0 Human 6.4 pIC50 = 6.4 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 394 6 2 4 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm00066a015
107686 10152 41 None 15 2 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm00024a007
3522 10152 41 None 15 2 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL131171 10152 41 None 15 2 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm00024a007
19797466 41372 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL142961 41372 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44297701 108468 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL299388 108468 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NCc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
11489240 102065 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 518 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
CHEMBL25639 102065 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 518 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CO)nc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
44274520 89358 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells at 100 nMTested for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells at 100 nM
ChEMBL 479 5 0 5 4.9 COc1ccccc1N1CCN(C(=O)CCc2c3n(c4ccc(C)cc24)C(=O)c2ccccc2-3)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21788 89358 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells at 100 nMTested for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells at 100 nM
ChEMBL 479 5 0 5 4.9 COc1ccccc1N1CCN(C(=O)CCc2c3n(c4ccc(C)cc24)C(=O)c2ccccc2-3)CC1 10.1016/s0960-894x(01)00183-4
44358861 125415 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)c(F)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL341681 125415 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 491 8 3 3 5.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1ccc(F)c(F)c1)c1ccccc1 10.1021/jm00022a010
15755299 107665 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 626 13 3 8 3.7 CC(C)(C)OC(=O)NCC(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL293726 107665 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 626 13 3 8 3.7 CC(C)(C)OC(=O)NCC(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
10325464 126912 0 None -25 3 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351236 126912 0 None -25 3 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
44458828 17931 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 408 3 0 3 5.6 CCN1/C(=C\C=C2CC[n+]3c2n(CC)c2cc4ccccc4cc23)Oc2ccccc21 10.1021/jm00085a015
CHEMBL1178368 17931 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 408 3 0 3 5.6 CCN1/C(=C\C=C2CC[n+]3c2n(CC)c2cc4ccccc4cc23)Oc2ccccc21 10.1021/jm00085a015
CHEMBL23533 17931 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 408 3 0 3 5.6 CCN1/C(=C\C=C2CC[n+]3c2n(CC)c2cc4ccccc4cc23)Oc2ccccc21 10.1021/jm00085a015
44281769 116437 7 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cellsInhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/0960-894X(95)00582-E
CHEMBL32248 116437 7 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cellsInhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/0960-894X(95)00582-E
19098237 43895 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL145265 43895 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 533 7 0 2 7.7 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(Cc2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm00024a007
10428330 177001 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 356 4 1 3 3.5 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(F)cc(F)c1 10.1021/jm00006a011
CHEMBL444552 177001 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 356 4 1 3 3.5 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1cc(F)cc(F)c1 10.1021/jm00006a011
44297562 201816 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 629 9 1 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)Cc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54940 201816 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 629 9 1 5 4.6 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NC(=O)Cc3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10576866 118268 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 485 6 1 5 5.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
CHEMBL327736 118268 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 485 6 1 5 5.2 FC(F)(F)c1cc(CO[C@H]2CCCN(Cc3nn[nH]n3)[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9506534
46881600 13878 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 493 5 1 3 5.3 CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO 10.1016/j.bmcl.2010.01.065
CHEMBL1085196 13878 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 493 5 1 3 5.3 CC(=O)N1C[C@H](O[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2)[C@@H]1CO 10.1016/j.bmcl.2010.01.065
44302017 206110 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Concentration required for binding affinity to neurokinin (NK1) receptor in human IM9 cellsConcentration required for binding affinity to neurokinin (NK1) receptor in human IM9 cells
ChEMBL 446 9 4 3 4.3 CC(C)COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL59060 206110 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Concentration required for binding affinity to neurokinin (NK1) receptor in human IM9 cellsConcentration required for binding affinity to neurokinin (NK1) receptor in human IM9 cells
ChEMBL 446 9 4 3 4.3 CC(C)COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
71541370 94216 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 432 5 0 3 5.6 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333641 94216 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 432 5 0 3 5.6 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2012.11.094
10404051 92822 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 325 6 1 3 3.1 CC(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23077 92822 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 325 6 1 3 3.1 CC(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
10027661 66473 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 2 2 4.3 O=C1CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C(Cc2c[nH]c3ccccc23)N1 10.1021/jm00006a011
CHEMBL172308 66473 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 469 4 2 2 4.3 O=C1CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C(Cc2c[nH]c3ccccc23)N1 10.1021/jm00006a011
54585203 67933 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 452 4 1 2 6.3 Cc1cc(-c2ccccc2)c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 10.1016/j.bmc.2011.02.031
CHEMBL1765501 67933 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 452 4 1 2 6.3 Cc1cc(-c2ccccc2)c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)n1 10.1016/j.bmc.2011.02.031
10053205 123363 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL336589 123363 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
46884469 14765 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 594 6 0 4 7.2 COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL1090651 14765 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 594 6 0 4 7.2 COc1cc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)ccn1 10.1016/j.bmcl.2010.01.120
CHEMBL2369630 216424 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 1 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44344195 170139 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 475 5 1 3 6.2 Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 10.1016/S0960-894X(96)00623-3
CHEMBL419232 170139 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 475 5 1 3 6.2 Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 10.1016/S0960-894X(96)00623-3
CHEMBL307433 217759 0 None - 0 Guinea pig 7.4 pIC50 = 7.4 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
44328357 118314 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 490 6 1 2 7.0 FC(F)(F)c1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL327943 118314 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 490 6 1 2 7.0 FC(F)(F)c1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44287556 106988 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 397 6 0 1 6.2 CN(Cc1cc(Cl)cc(Cl)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL288382 106988 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 397 6 0 1 6.2 CN(Cc1cc(Cl)cc(Cl)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
11641636 112594 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 487 6 0 3 6.1 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126976 112594 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 487 6 0 3 6.1 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCOCC3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
24801457 94218 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 3 5.1 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333643 94218 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 3 5.1 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
44415472 146379 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL379744 146379 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@H]1CC[C@@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44433781 96702 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 6.4 CC(C)(C)OC(=O)N1CC[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2007.08.028
CHEMBL237992 96702 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 530 4 1 3 6.4 CC(C)(C)OC(=O)N1CC[C@H](c2ccccc2)[C@@H](C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1 10.1016/j.bmcl.2007.08.028
44303900 169683 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 751 15 3 10 3.9 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1C(C(=O)c2ccccc2)CC[C@H]1C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL417390 169683 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 751 15 3 10 3.9 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N1C(C(=O)c2ccccc2)CC[C@H]1C(=O)OCc1ccccc1 10.1021/jm00089a011
15154449 18752 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 5 1 3 5.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 10.1021/jm00085a015
54080603 18752 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 5 1 3 5.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL1183064 18752 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 5 1 3 5.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 10.1021/jm00085a015
CHEMBL278135 18752 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 438 5 1 3 5.4 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CCO)c2cc3ccccc3cc21 10.1021/jm00085a015
44297724 108700 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 585 8 1 4 5.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(CCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL301008 108700 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 585 8 1 4 5.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(CCc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44286772 174618 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.2 O=C(NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL43085 174618 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 6 1 1 6.2 O=C(NCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
56668295 73247 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 409 5 0 2 5.3 O=C1CCN(Cc2ccccc2F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817836 73247 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 409 5 0 2 5.3 O=C1CCN(Cc2ccccc2F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852171 73247 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 409 5 0 2 5.3 O=C1CCN(Cc2ccccc2F)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
10393390 105053 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 576 8 0 3 7.6 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
CHEMBL27463 105053 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 576 8 0 3 7.6 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
10317867 11636 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 384 6 1 4 4.5 COc1ccccc1CNCc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104345 11636 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 384 6 1 4 4.5 COc1ccccc1CNCc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44287511 151516 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL39089 151516 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 451 5 0 1 6.5 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
24785190 128848 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 415 6 1 3 5.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccco2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596457 128848 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 415 6 1 3 5.8 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccco2)c1 10.1016/j.bmcl.2015.04.098
52941506 24539 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
CHEMBL1258732 24539 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 530 4 1 3 5.7 C[C@@H](O[C@H]1CN2C(=O)[C@@H]3C[C@H](N)C[C@@H]3[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.07.058
76314659 112589 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 501 8 0 2 7.9 CC(C)N(C(C)C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126971 112589 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 501 8 0 2 7.9 CC(C)N(C(C)C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
44287819 108173 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 486 5 0 4 3.6 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)C(=O)C[S+]([O-])C2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL297244 108173 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 486 5 0 4 3.6 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)C(=O)C[S+]([O-])C2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
10386984 12185 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 5 1 4 4.5 COc1ccccc1CNC(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL107220 12185 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 412 5 1 4 4.5 COc1ccccc1CNC(=O)c1c(-c2ccccc2C)c2ccccc2c(=O)n1C 10.1021/jm00016a014
10625208 62635 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 500 10 1 5 3.7 COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccccc1)C(C)=O 10.1021/jm950616c
CHEMBL162332 62635 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 500 10 1 5 3.7 COc1ccccc1CN(CC(NC(=O)CN1CCN(c2ccccc2)CC1)c1ccccc1)C(C)=O 10.1021/jm950616c
76332768 112583 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 459 6 0 2 6.7 CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
CHEMBL3126966 112583 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 459 6 0 2 6.7 CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2014.01.036
44288896 175766 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL43912 175766 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL2372519 217047 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1CCc2cc3ccccc3cc21)C(N)=O 10.1021/jm00037a009
44277452 107859 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1ccc(C)c(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
CHEMBL29487 107859 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 411 6 0 2 6.1 Cc1ccc(C)c(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80349-2
44348667 121105 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL124542 121105 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL333069 121105 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44212283 66633 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 593 9 1 4 5.6 COc1ccccc1CC(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL172915 66633 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 593 9 1 4 5.6 COc1ccccc1CC(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
71541371 94221 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 374 5 0 3 4.0 CN1CCC(COCc2cncc(Br)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333646 94221 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 374 5 0 3 4.0 CN1CCC(COCc2cncc(Br)c2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
10253192 11695 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 449 4 1 3 5.7 CN(Cc1ccccc1Cl)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104654 11695 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 449 4 1 3 5.7 CN(Cc1ccccc1Cl)C(=O)Nc1c(-c2ccc(F)cc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44312028 109629 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 558 9 1 5 5.1 CSN1CC2(CCN(C(=O)N[C@@H](COCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL305609 109629 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 558 9 1 5 5.1 CSN1CC2(CCN(C(=O)N[C@@H](COCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10627355 126788 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
CHEMBL350151 126788 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 596 13 2 6 3.6 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CN(C)C 10.1021/jm950616c
44328395 114289 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 490 6 1 2 6.7 FC(F)(F)c1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL318629 114289 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 490 6 1 2 6.7 FC(F)(F)c1ccccc1CNC1C2C3CCCC2CN(C3)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
19003169 109565 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 269 6 1 2 3.4 Cc1cc(C)cc(COCC(N)Cc2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL305274 109565 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 269 6 1 2 3.4 Cc1cc(C)cc(COCC(N)Cc2ccccc2)c1 10.1016/S0960-894X(00)80063-3
44321047 212960 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 10.1021/jm00092a009
CHEMBL86378 212960 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 336 6 1 3 3.5 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1Cc1ccccc1 10.1021/jm00092a009
44326328 213884 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 295 5 1 2 4.2 N[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL92032 213884 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 295 5 1 2 4.2 N[C@H](COCc1cc(Cl)cc(Cl)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
44346420 21077 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was evaluated for its affinity, measured in [3H]SP binding assay on human IM9 lymphoblast cultured cell lineCompound was evaluated for its affinity, measured in [3H]SP binding assay on human IM9 lymphoblast cultured cell line
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
CHEMBL119990 21077 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was evaluated for its affinity, measured in [3H]SP binding assay on human IM9 lymphoblast cultured cell lineCompound was evaluated for its affinity, measured in [3H]SP binding assay on human IM9 lymphoblast cultured cell line
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
107686 10152 41 None - 2 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
3522 10152 41 None - 2 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL131171 10152 41 None - 2 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
18782568 214061 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 321 3 1 3 4.0 COc1ccccc1C1=CC2(CCCNC2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
CHEMBL93184 214061 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 321 3 1 3 4.0 COc1ccccc1C1=CC2(CCCNC2c2ccccc2)OC1 10.1016/s0960-894x(02)00509-7
24784955 128858 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 450 6 1 3 6.1 N#Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596467 128858 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 450 6 1 3 6.1 N#Cc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL311405 217878 16 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O 10.1016/0960-894X(94)85022-4
44305865 107460 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 582 10 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(CC(=O)O)c2ccccc12 10.1021/jm00039a022
CHEMBL292346 107460 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 582 10 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(CC(=O)O)c2ccccc12 10.1021/jm00039a022
CHEMBL2092883 215981 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
10258592 105983 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 639 7 0 4 6.8 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
CHEMBL281481 105983 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 639 7 0 4 6.8 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
44368172 128293 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 444 8 2 4 4.9 FC(F)(F)c1cc(COC[C@@H](NCc2nc[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(97)10163-9
CHEMBL358409 128293 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 444 8 2 4 4.9 FC(F)(F)c1cc(COC[C@@H](NCc2nc[nH]n2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/s0960-894x(97)10163-9
10097954 138899 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 513 9 2 3 5.0 CN(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
CHEMBL369601 138899 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 513 9 2 3 5.0 CN(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00006a012
44287609 107137 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 503 6 0 5 5.4 COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL289666 107137 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 503 6 0 5 5.4 COc1ccccc1[C@H](SC)C(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
24783681 128859 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596468 128859 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 443 6 1 2 6.4 Fc1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44415458 87124 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 7.3 FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCCCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.035
CHEMBL214317 87124 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 7.3 FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCCCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.035
44415539 145757 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 5 1 2 5.8 CN(C)C(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL378537 145757 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 474 5 1 2 5.8 CN(C)C(=O)N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44305864 210276 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 525 8 3 5 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1[nH]nc2ccccc12 10.1021/jm00039a022
CHEMBL66193 210276 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 525 8 3 5 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1[nH]nc2ccccc12 10.1021/jm00039a022
44358519 37531 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 531 9 1 4 6.1 CC(C)Oc1cccc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
CHEMBL139569 37531 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 531 9 1 4 6.1 CC(C)Oc1cccc(CC(=O)NCC(c2ccc(Cl)c(Cl)c2)N2CCC(N3CCCCC3)CC2)c1 10.1021/jm000986n
44338584 14929 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 500 6 1 3 6.2 FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL109183 14929 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 500 6 1 3 6.2 FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
22353151 15903 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
CHEMBL109937 15903 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00563-2
44338618 116103 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 450 6 1 3 5.0 Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
CHEMBL321892 116103 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 450 6 1 3 5.0 Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
44346558 22160 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.0 CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
CHEMBL121459 22160 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 586 9 3 3 6.0 CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)c1c[nH]c2ccccc12 10.1021/jm9700171
24889114 14523 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 569 5 0 5 6.5 Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1089081 14523 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 569 5 0 5 6.5 Cc1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
11743365 114165 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 429 4 0 4 4.6 Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccc(F)cc3)c3cccnc3c(=O)n2C)c1 10.1021/jm00016a014
CHEMBL317870 114165 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 429 4 0 4 4.6 Cc1cc(C)cc(CN(C)C(=O)c2c(-c3ccc(F)cc3)c3cccnc3c(=O)n2C)c1 10.1021/jm00016a014
44178113 68038 0 None -12 3 Rat 8.3 pIC50 = 8.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766208 68038 0 None -12 3 Rat 8.3 pIC50 = 8.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
44274530 105709 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 549 7 0 4 7.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C(C)C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL279488 105709 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 549 7 0 4 7.5 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(C(C)C)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
24782655 128861 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596470 128861 0 None - 0 Mongolian jird 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1cccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)c1 10.1016/j.bmcl.2015.04.098
44415486 87689 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 499 7 3 4 5.8 Oc1nc(CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)c[nH]1 10.1016/j.bmcl.2006.06.035
CHEMBL215315 87689 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 499 7 3 4 5.8 Oc1nc(CN[C@@H]2CC[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H]2c2ccccc2)c[nH]1 10.1016/j.bmcl.2006.06.035
44358469 37917 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 629 11 3 5 5.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N(CCO)CCO)CC1 10.1021/jm000986n
CHEMBL140023 37917 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 629 11 3 5 5.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccc(Cl)c(Cl)c1)N1CCC(N(CCO)CCO)CC1 10.1021/jm000986n
10623791 37678 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 459 5 0 2 5.8 CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL139784 37678 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 459 5 0 2 5.8 CC(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
71541572 94182 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 440 6 0 3 5.4 CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333608 94182 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 440 6 0 3 5.4 CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
71541573 94183 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333609 94183 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 422 6 0 3 5.2 CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
22293463 108093 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 7 0 2 9.7 CC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL296629 108093 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 607 7 0 2 9.7 CC(OC[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
44415412 85501 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 461 5 1 3 5.9 COC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL211257 85501 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 461 5 1 3 5.9 COC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
10553136 172103 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 491 10 2 5 2.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C)CC1)C(C)=O 10.1021/jm950616c
CHEMBL423464 172103 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 491 10 2 5 2.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C)CC1)C(C)=O 10.1021/jm950616c
46884516 14598 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 567 5 0 4 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089533 14598 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 567 5 0 4 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(C)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44306036 20540 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 553 8 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(N)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL1195366 20540 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 553 8 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(N)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL554413 20540 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 553 8 3 6 2.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(N)cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44306318 210564 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 508 8 2 3 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL68225 210564 0 None - 0 Guinea pig 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 508 8 2 3 4.2 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCCN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44358545 34212 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 7 1 3 6.1 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL136832 34212 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 7 1 3 6.1 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
9976640 203407 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1021/jm9700171
CHEMBL56427 203407 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1021/jm9700171
9976640 203407 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
CHEMBL56427 203407 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 373 8 0 2 5.6 Cc1cc(C)cc(COC[C@H](C(c2ccccc2)c2ccccc2)N(C)C)c1 10.1016/S0960-894X(01)80531-X
44274170 83847 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccncc3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL20736 83847 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3ccncc3)ccc21 10.1016/s0960-894x(01)00182-2
44274199 105534 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3cccnc3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL278088 105534 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 563 7 1 4 7.1 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(-c3cccnc3)ccc21 10.1016/s0960-894x(01)00182-2
10392469 201634 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro affinity for specific binding at Gerbil tachykinin receptor 1In vitro affinity for specific binding at Gerbil tachykinin receptor 1
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL539928 201634 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro affinity for specific binding at Gerbil tachykinin receptor 1In vitro affinity for specific binding at Gerbil tachykinin receptor 1
ChEMBL 538 10 3 5 5.6 C[C@H](NC(=O)[C@](Cc1c[nH]c2ccccc12)(CN(C)C)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
44370928 54530 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 619 18 1 4 7.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
CHEMBL154803 54530 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 619 18 1 4 7.1 CCCCCN(CCCCC)C(=O)[C@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
10603392 64227 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 583 12 2 6 4.7 CCOC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL165566 64227 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 583 12 2 6 4.7 CCOC(=O)N(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
44274118 105730 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 473 6 1 3 5.8 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL279674 105730 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 473 6 1 3 5.8 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00182-2
57397019 78309 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
CHEMBL1951617 78309 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
CHEMBL1962935 78309 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from tachykinin NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 444 4 1 2 5.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.11.048
46884519 14865 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 4 7.4 Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 10.1016/j.bmcl.2010.01.120
CHEMBL1091342 14865 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 4 7.4 Cc1noc(C)c1C1=CC(=O)N2C[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2C1 10.1016/j.bmcl.2010.01.120
24752434 15905 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
CHEMBL1099372 15905 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in the presence of 50 percent human serum
ChEMBL 491 4 1 3 5.1 C[C@@H](O[C@H]1CN2C(=O)C(O)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.065
10743826 125364 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 495 6 0 3 5.2 CS(=O)(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
CHEMBL341656 125364 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 495 6 0 3 5.2 CS(=O)(=O)N1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1021/jm980376b
44415484 175717 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL438789 175717 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44326361 118270 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 434 8 1 3 4.4 CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL327765 118270 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 434 8 1 3 4.4 CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
44326361 118270 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 434 8 1 3 4.4 CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL327765 118270 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 434 8 1 3 4.4 CN(CC(N)=O)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
9874168 212483 4 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL82386 212483 4 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
23025461 73226 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 400 6 1 4 4.5 COc1ccc(N)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852063 73226 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 400 6 1 4 4.5 COc1ccc(N)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL3216952 73226 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 400 6 1 4 4.5 COc1ccc(N)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1 10.1016/j.bmc.2011.07.014
9805809 109864 8 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro affinity for specific binding at Gerbil tachykinin receptor 1In vitro affinity for specific binding at Gerbil tachykinin receptor 1
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
CHEMBL307488 109864 8 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro affinity for specific binding at Gerbil tachykinin receptor 1In vitro affinity for specific binding at Gerbil tachykinin receptor 1
ChEMBL 495 8 3 4 6.0 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cc2ccccc2o1)c1ccccc1 10.1021/jm010825z
11844212 105425 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 590 7 1 2 7.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC2(C=Cc3ccccc32)CC1)c1ccc(F)cc1 10.1021/jm060439n
CHEMBL277279 105425 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of NK1Inhibition of NK1
ChEMBL 590 7 1 2 7.7 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC2(C=Cc3ccccc32)CC1)c1ccc(F)cc1 10.1021/jm060439n
44348667 121105 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL124542 121105 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL333069 121105 1 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 439 0 1 4 5.2 C#C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
44338652 115387 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00563-2
CHEMBL320544 115387 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00563-2
44322736 213780 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 448 6 1 2 6.1 Fc1ccc(N(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 10.1016/s0960-894x(01)00727-2
CHEMBL91436 213780 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 448 6 1 2 6.1 Fc1ccc(N(CCCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)cc1 10.1016/s0960-894x(01)00727-2
44233185 201601 0 None -181 4 Rat 7.3 pIC50 = 7.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL539193 201601 0 None -181 4 Rat 7.3 pIC50 = 7.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL5083565 221650 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]SP from human NK1R expressed in U373 MG cells incubated for 30 mins by radioligand binding assayDisplacement of [125I]SP from human NK1R expressed in U373 MG cells incubated for 30 mins by radioligand binding assay
ChEMBL None None None C[C@@H](O[C@H]1O[C@@H]2CC[C@@H](c3ccccc3)O[C@@H]2[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
44458789 148591 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 1668 41 14 16 4.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O 10.1021/jm00109a034
CHEMBL386306 148591 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 1668 41 14 16 4.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O 10.1021/jm00109a034
44458351 106166 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL282657 106166 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 443 5 0 2 5.9 FC(F)(F)c1cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00205-8
CHEMBL410808 219622 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
15755314 108975 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 711 17 4 9 3.4 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCCc1ccccc1 10.1021/jm00089a011
CHEMBL302843 108975 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 711 17 4 9 3.4 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCCc1ccccc1 10.1021/jm00089a011
44458789 148591 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 1668 41 14 16 4.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O 10.1021/jm00085a015
CHEMBL386306 148591 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 1668 41 14 16 4.5 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C(Cl)C(Cl)CN1C(=O)[C@H](C)NC(=O)[C@@H]1C(c2cccnc2)CCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)O 10.1021/jm00085a015
18655106 207248 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 464 10 0 2 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 10.1016/S0960-894X(01)80747-2
CHEMBL59854 207248 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 464 10 0 2 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 10.1016/S0960-894X(01)80747-2
44287443 107048 1 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 528 9 0 5 4.9 CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL288942 107048 1 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 528 9 0 5 4.9 CN(C)CCCOc1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
10697072 62587 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 511 11 3 5 3.8 COc1ccccc1CNCC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL162288 62587 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 511 11 3 5 3.8 COc1ccccc1CNCC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
22901331 18753 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 18753 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 18753 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 18753 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 18753 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
22901331 18753 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
54435601 18753 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
59922977 18753 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
CHEMBL1183068 18753 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
CHEMBL278294 18753 0 None - 1 Rat 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00085a015
44318310 212437 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.8 Fc1ccc(C2NCCOC23CCC(c2cccc(C(F)(F)F)c2)CO3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL81986 212437 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 395 2 1 3 4.8 Fc1ccc(C2NCCOC23CCC(c2cccc(C(F)(F)F)c2)CO3)cc1 10.1016/s0960-894x(02)00506-1
44333682 11394 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 619 6 1 3 7.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cc(Br)cc(Br)c2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL102887 11394 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 619 6 1 3 7.4 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2cc(Br)cc(Br)c2)c1 10.1016/S0960-894X(96)00563-X
11490127 98859 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 580 5 0 2 8.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CBr)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL24194 98859 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 580 5 0 2 8.1 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CBr)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
12225557 127955 1 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(01)81197-5
CHEMBL357717 127955 1 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 382 6 1 2 5.1 c1ccc(CN[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(01)81197-5
24801792 94219 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 3 5.1 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2F)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333644 94219 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 416 5 0 3 5.1 CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2F)CC1 10.1016/j.bmcl.2012.11.094
54582296 67928 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 486 5 0 2 6.8 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)ccnc1CCl 10.1016/j.bmc.2011.02.031
CHEMBL1765498 67928 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 486 5 0 2 6.8 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)ccnc1CCl 10.1016/j.bmc.2011.02.031
10473960 93057 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm9700171
CHEMBL23129 93057 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm9700171
44177570 68034 0 None -169 4 Rat 7.3 pIC50 = 7.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766204 68034 0 None -169 4 Rat 7.3 pIC50 = 7.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
68932301 131570 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 594 4 0 4 4.9 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642169 131570 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 594 4 0 4 4.9 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
44288795 175051 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 467 6 3 5 4.7 O=C(c1cc(O)cc(O)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL43394 175051 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 467 6 3 5 4.7 O=C(c1cc(O)cc(O)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10917690 214384 1 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory concentration against neurokinin NK1 receptorInhibitory concentration against neurokinin NK1 receptor
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1021/jm058225d
CHEMBL95051 214384 1 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory concentration against neurokinin NK1 receptorInhibitory concentration against neurokinin NK1 receptor
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1021/jm058225d
44286718 174506 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL43027 174506 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 437 5 1 1 6.2 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44383969 135824 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL367034 135824 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
44383969 135824 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
CHEMBL367034 135824 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1cccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00006a012
54585202 67929 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 536 5 1 4 5.8 Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765499 67929 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 536 5 1 4 5.8 Cc1nc(N2CCN(C)CC2)cc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
54585205 67938 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 492 4 0 4 6.0 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 10.1016/j.bmc.2011.02.031
CHEMBL1765506 67938 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 492 4 0 4 6.0 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 10.1016/j.bmc.2011.02.031
46884432 14694 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 588 5 0 3 7.7 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090285 14694 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 588 5 0 3 7.7 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(C#N)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44297602 202021 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 614 9 1 5 4.9 CN(Cc1ccc(Cl)c(Cl)c1)CC(NCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 10.1016/s0960-894x(98)00320-5
CHEMBL55098 202021 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 614 9 1 5 4.9 CN(Cc1ccc(Cl)c(Cl)c1)CC(NCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12 10.1016/s0960-894x(98)00320-5
CHEMBL2114442 216033 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
24783683 128856 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 455 7 1 3 6.2 COc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596465 128856 0 None - 0 Mongolian jird 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 455 7 1 3 6.2 COc1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
24889111 14696 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 656 7 1 4 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090287 14696 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 656 7 1 4 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccc(NS(C)(=O)=O)cc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10370593 13035 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 561 4 1 3 7.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL108164 13035 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 561 4 1 3 7.5 Cc1cc2c(-c3ccccc3)c(NC(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44288976 170010 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1cccc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL418438 170010 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 469 6 1 3 5.9 O=C(c1cccc(Cl)c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10349900 113526 0 None 39 3 Human 7.3 pIC50 = 7.3 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 113526 0 None 39 3 Human 7.3 pIC50 = 7.3 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44312887 109714 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 626 14 6 6 1.4 C[C@@H](O)C(NC(=O)CC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O 10.1021/jm00068a003
CHEMBL306267 109714 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Tested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranesTested for inhibition against [3H]-SP (substance P) (1 nM) binding to NK1 receptor in guinea pig lung membranes
ChEMBL 626 14 6 6 1.4 C[C@@H](O)C(NC(=O)CC(NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(N)=O 10.1021/jm00068a003
24782658 128851 0 None - 0 Mongolian jird 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 475 6 1 2 7.4 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2cccc3ccccc23)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596460 128851 0 None - 0 Mongolian jird 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 475 6 1 2 7.4 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2cccc3ccccc23)c1 10.1016/j.bmcl.2015.04.098
22851562 173232 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL42778 173232 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
44297451 107436 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL292211 107436 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
16755232 180367 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 514 4 1 4 6.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cnnc12 10.1016/j.bmc.2008.05.067
CHEMBL453314 180367 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 514 4 1 4 6.5 O=C(NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1c(-c2ccccc2)c2ccccc2n2cnnc12 10.1016/j.bmc.2008.05.067
21308488 108280 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 12 1 5 5.4 CS(=O)(=O)N(CC1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)c1ccccc1 10.1016/s0960-894x(98)00319-9
CHEMBL297957 108280 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 12 1 5 5.4 CS(=O)(=O)N(CC1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)c1ccccc1 10.1016/s0960-894x(98)00319-9
CHEMBL2369601 216414 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm960281e
10043484 96240 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm9700171
CHEMBL23715 96240 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm9700171
44334006 114393 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 520 6 1 3 6.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(CO)(c3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
CHEMBL318989 114393 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.
ChEMBL 520 6 1 3 6.6 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(CO)(c3ccccc3)CC2)c2cc(Cl)ccc21 10.1016/s0960-894x(01)00616-3
44297513 108382 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 547 9 1 5 4.0 Cc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 10.1016/s0960-894x(98)00320-5
CHEMBL298772 108382 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 547 9 1 5 4.0 Cc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 10.1016/s0960-894x(98)00320-5
10499624 123412 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 337 5 1 2 4.8 CC(C)(C)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL336931 123412 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 337 5 1 2 4.8 CC(C)(C)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
44308930 211106 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL71498 211106 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
44308930 211106 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
CHEMBL71498 211106 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 255 5 1 2 3.5 Cc1cc(C)cc(COC[C@@H](N)c2ccccc2)c1 10.1016/0960-894X(95)00476-A
44299916 202581 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 387 9 1 2 6.0 Cc1cc(C)cc(COCC(NC(C)C)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL55796 202581 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 387 9 1 2 6.0 Cc1cc(C)cc(COCC(NC(C)C)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
9869033 107200 5 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL290364 107200 5 None - 0 Human 7.3 pIC50 = 7.3 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
56675290 73223 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1OC 10.1016/j.bmc.2011.07.014
CHEMBL1817884 73223 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1OC 10.1016/j.bmc.2011.07.014
CHEMBL1852032 73223 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1cccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c1OC 10.1016/j.bmc.2011.07.014
16755257 180165 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 543 4 0 5 6.6 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 10.1016/j.bmc.2008.05.067
CHEMBL452794 180165 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 543 4 0 5 6.6 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3nnnn3c3ccccc23)cc1 10.1016/j.bmc.2008.05.067
44324532 213622 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 578 14 1 4 5.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)C)C1 10.1016/S0960-894X(01)80747-2
CHEMBL90547 213622 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 578 14 1 4 5.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)C)C1 10.1016/S0960-894X(01)80747-2
15755319 107457 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 669 15 5 7 3.8 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL292320 107457 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 669 15 5 7 3.8 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
10410206 86359 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
CHEMBL2114308 86359 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 426 7 2 3 4.9 Cc1cc(C)cc(COC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
10410322 106179 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 428 8 2 4 4.3 COc1ccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)cc1 10.1021/jm00035a006
CHEMBL282728 106179 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 428 8 2 4 4.3 COc1ccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)cc1 10.1021/jm00035a006
10043484 96240 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm00035a006
CHEMBL23715 96240 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm00035a006
10043484 96240 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm00066a015
CHEMBL23715 96240 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 350 6 1 3 4.0 Cc1cc(C)cc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C)c1 10.1021/jm00066a015
44297931 199493 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 511 9 1 4 5.3 Cc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL52198 199493 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 511 9 1 4 5.3 Cc1ccccc1N1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1 10.1016/s0960-894x(98)00319-9
44287191 164460 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL40817 164460 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 6 0 1 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)CC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
44275987 106120 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
CHEMBL282331 106120 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding potency against SP receptor in bovine caudate using [3H]- as radioligandBinding potency against SP receptor in bovine caudate using [3H]- as radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
19797477 45438 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 413 7 0 3 5.5 COc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL146552 45438 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 413 7 0 3 5.5 COc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
9984184 211428 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 6 2 2 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73618 211428 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 6 2 2 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
44383681 173048 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 430 6 1 2 6.1 Clc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
CHEMBL426939 173048 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 430 6 1 2 6.1 Clc1ccccc1CN[C@H]1C2CCCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80693-9
10411026 68130 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 441 4 2 2 5.2 FC(F)(F)c1cc(CN2CCNC(Cc3c[nH]c4ccccc34)C2)cc(C(F)(F)F)c1 10.1021/jm00006a011
CHEMBL176772 68130 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 441 4 2 2 5.2 FC(F)(F)c1cc(CN2CCNC(Cc3c[nH]c4ccccc34)C2)cc(C(F)(F)F)c1 10.1021/jm00006a011
44319341 212669 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 572 10 1 7 3.8 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccnc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL83885 212669 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 572 10 1 7 3.8 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccnc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44297493 169928 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 10.1016/s0960-894x(98)00320-5
CHEMBL417914 169928 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1ccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)cc1 10.1016/s0960-894x(98)00320-5
10620143 106038 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL281828 106038 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
54582297 67936 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 493 4 0 5 5.4 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 10.1016/j.bmc.2011.02.031
CHEMBL1765504 67936 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 493 4 0 5 5.4 Cc1c(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nnnn12 10.1016/j.bmc.2011.02.031
71583092 95000 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 5.1 O=C1CC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CCN1 10.1016/j.bmc.2013.02.010
CHEMBL2347703 95000 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 431 5 1 2 5.1 O=C1CC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CCN1 10.1016/j.bmc.2013.02.010
44324527 113315 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 550 13 2 4 4.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN)C1 10.1016/S0960-894X(01)80747-2
CHEMBL314084 113315 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 550 13 2 4 4.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN)C1 10.1016/S0960-894X(01)80747-2
10620143 106038 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm9700171
CHEMBL281828 106038 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1cccc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm9700171
44274242 105927 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 541 6 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)cc(Cl)c23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL281149 105927 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 541 6 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cc(Cl)cc(Cl)c23)CC1 10.1016/s0960-894x(01)00182-2
10553958 108146 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL297068 108146 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO CellsTested for binding affinity by measuring displacement of [125I]SP from human NK-1 receptor in CHO Cells
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(00)80046-3
CHEMBL5076397 221214 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of tachykinin NK1 receptor (unknown origin)Inhibition of tachykinin NK1 receptor (unknown origin)
ChEMBL None None None O[C@H]1COC[C@H]1N1CC[C@@H](c2cc3nc(Nc4cnn([C@@H]5CC5(F)F)c4Cl)ncc3cc2Cl)[C@H](F)C1 10.1021/acs.jmedchem.1c01968
10553958 108146 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
CHEMBL297068 108146 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 519 6 0 2 7.5 FC(F)(F)c1cc(CO[C@@H]2C3CCN(CC3)[C@@H]2C(c2ccccc2)c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm9700171
44297469 108558 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL300005 108558 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44328545 214431 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 456 6 1 2 6.6 Clc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL95270 214431 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 456 6 1 2 6.6 Clc1ccccc1CNC1C2CC3CCCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL1196922 215375 0 None - 0 Guinea pig 4.2 pIC50 = 4.2 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00089a011
CHEMBL558620 215375 0 None - 0 Guinea pig 4.2 pIC50 = 4.2 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00089a011
10692651 107866 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
CHEMBL294960 107866 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 405 4 1 3 4.9 FC(F)(F)c1cc(CO[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1021/jm950654w
44294261 86483 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 593 7 0 2 9.1 Fc1ccc(C2CCN([C@H]3CC[C@@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2115454 86483 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 593 7 0 2 9.1 Fc1ccc(C2CCN([C@H]3CC[C@@](COCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2112241 216007 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None COc1ccc(C[C@@H]2NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H]([C@@H](C)O)NC2=O)cc1 10.1021/jm960281e
44375315 63281 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assayIn vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL163510 63281 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assayIn vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
10530317 12000 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 532 9 2 3 4.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL106239 12000 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 532 9 2 3 4.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl 10.1021/jm970499g
44286754 169923 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 7 1 1 6.6 O=C(NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL417881 169923 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 465 7 1 1 6.6 O=C(NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
104974 10248 31 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
2111 10248 31 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
3481 10248 31 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
CHEMBL308148 10248 31 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
DB06660 10248 31 None -1202 7 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
CHEMBL2369604 216416 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
44324531 213534 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 565 13 2 4 4.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCC(=O)O)C1 10.1016/S0960-894X(01)80747-2
CHEMBL90035 213534 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 565 13 2 4 4.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCC(=O)O)C1 10.1016/S0960-894X(01)80747-2
44433803 153572 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 10.1016/j.bmcl.2007.08.028
CHEMBL392465 153572 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 654 5 0 5 6.8 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](c3noc(C(C)(C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)C2)CC1 10.1016/j.bmcl.2007.08.028
44289934 108036 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 529 12 2 4 5.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccc(F)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL296216 108036 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 529 12 2 4 5.1 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)c1ccc(F)cc1)C(C)=O 10.1016/s0960-894x(01)00250-5
44358672 126136 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 7 0 5 4.9 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Br 10.1021/jm000986n
CHEMBL344378 126136 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 541 7 0 5 4.9 CN(CC(c1cccc2c1OCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1ccccc1Br 10.1021/jm000986n
21121353 108250 0 None 19 3 Human 8.2 pIC50 = 8.2 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 108250 0 None 19 3 Human 8.2 pIC50 = 8.2 Binding
Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
71452678 85352 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 591 5 2 3 6.4 Cc1ccc(-c2ccc(C(=O)N[C@@H]3CCCCNC3=O)cc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2112211 85352 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 591 5 2 3 6.4 Cc1ccc(-c2ccc(C(=O)N[C@@H]3CCCCNC3=O)cc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1016/s0960-894x(02)00382-7
9868530 84107 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 453 6 1 3 5.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL20837 84107 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 453 6 1 3 5.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
24800398 94185 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 450 6 0 3 6.1 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CCCC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333610 94185 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 450 6 0 3 6.1 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CCCC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
56678486 73243 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 416 5 0 3 5.1 N#Cc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817837 73243 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 416 5 0 3 5.1 N#Cc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852157 73243 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 416 5 0 3 5.1 N#Cc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
9874168 212483 4 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL82386 212483 4 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
44408144 82042 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 498 4 0 2 6.4 CN(C)[C@H]1CC[C@](c2ccccc2)(N2CCC(c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2=O)CC1 10.1016/j.bmcl.2005.11.111
CHEMBL203700 82042 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human NK1 receptor expressed in CHO cells
ChEMBL 498 4 0 2 6.4 CN(C)[C@H]1CC[C@](c2ccccc2)(N2CCC(c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2=O)CC1 10.1016/j.bmcl.2005.11.111
44415411 145563 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 475 5 0 3 6.3 COC(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL378076 145563 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 475 5 0 3 6.3 COC(=O)N(C)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
2755911 82214 52 None 1 2 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL2042018 82214 52 None 1 2 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
44274104 87335 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 571 7 1 5 5.9 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCOCC3)ccc21 10.1016/s0960-894x(01)00182-2
CHEMBL21489 87335 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 571 7 1 5 5.9 Cn1c(-c2ccc(Cl)cc2)c(CCC(=O)N2CCC(O)(Cc3ccccc3)CC2)c2cc(N3CCOCC3)ccc21 10.1016/s0960-894x(01)00182-2
18669089 105715 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 509 6 1 3 6.7 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)(C)C)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL279523 105715 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 509 6 1 3 6.7 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(C(C)(C)C)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
24799187 94201 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 449 6 0 4 4.8 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CC=CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333626 94201 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 449 6 0 4 4.8 CN1CCC(COCc2cc(C(F)(F)F)cc(N3CC=CC3)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
22293526 86406 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.4 O=C(NC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
CHEMBL2115008 86406 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.4 O=C(NC[C@]1(c2ccccc2)CC[C@H](N2CCC(c3ccc(F)cc3)CC2)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00249-4
24785443 128846 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 425 6 1 2 6.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596455 128846 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 425 6 1 2 6.2 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2)c1 10.1016/j.bmcl.2015.04.098
44338586 13657 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
CHEMBL108422 13657 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 462 7 1 4 4.9 COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
71541577 94189 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 6 0 3 5.8 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333614 94189 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 438 6 0 3 5.8 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(Cl)c2)CC1 10.1016/j.bmcl.2012.11.094
46884518 14750 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 554 5 0 4 6.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090547 14750 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 554 5 0 4 6.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ncco3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44306436 107779 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 538 8 2 5 3.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL294370 107779 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 538 8 2 5 3.1 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
44335360 11637 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 608 8 2 4 5.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
CHEMBL104348 11637 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligandIn vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]Sar9-substance P as radioligand
ChEMBL 608 8 2 4 5.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
44358427 37787 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 643 7 1 3 8.0 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139903 37787 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 643 7 1 3 8.0 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(c1cc(Cl)cc(Cl)c1Cl)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44325096 118309 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 323 3 1 3 4.1 COc1ccccc1[C@H]1COC2(CCCNC2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
CHEMBL327928 118309 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from the cloned human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 323 3 1 3 4.1 COc1ccccc1[C@H]1COC2(CCCNC2c2ccccc2)C1 10.1016/s0960-894x(02)00509-7
58993609 128855 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596464 128855 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 470 7 1 4 6.1 O=[N+]([O-])c1ccccc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
40727876 122971 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 417 7 3 4 3.0 O=C(N[C@@H](Cc1ccccc1)C(=O)NNC(=O)c1ccccc1)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358423 122971 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 417 7 3 4 3.0 O=C(N[C@@H](Cc1ccccc1)C(=O)NNC(=O)c1ccccc1)OCc1ccccc1 10.1021/ml5002954
44297642 202229 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL55240 202229 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3ccc(Cl)cc3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
53379507 73227 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1817829 73227 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
CHEMBL1852067 73227 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccccc1CN1CCC(=O)C(C(c2ccc(F)cc2)c2ccc(F)cc2)C1 10.1016/j.bmc.2011.07.014
10390130 106017 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 474 6 2 2 5.9 NC(=O)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
CHEMBL281717 106017 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 474 6 2 2 5.9 NC(=O)NC[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00220-N
11619202 94998 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 1 2 6.3 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347697 94998 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 1 2 6.3 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
107686 10152 41 None 15 2 Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
3522 10152 41 None 15 2 Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL131171 10152 41 None 15 2 Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in rat brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
44299943 202341 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 359 8 1 2 5.2 CNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL55476 202341 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 359 8 1 2 5.2 CNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
10602065 42171 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 521 8 0 2 7.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(CCc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL143775 42171 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 521 8 0 2 7.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(CCc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
44358670 36745 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 545 7 1 5 4.9 CC(C)N1CCN(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 10.1021/jm000986n
CHEMBL138853 36745 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 545 7 1 5 4.9 CC(C)N1CCN(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cccc3c2OCO3)CC1 10.1021/jm000986n
44297463 169898 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 611 9 1 5 4.5 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Br)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL417731 169898 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 611 9 1 5 4.5 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cccc(Br)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10327540 170284 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1Binding affinity towards Tachykinin receptor 1
ChEMBL 720 21 2 7 7.5 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm960281e
CHEMBL420221 170284 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1Binding affinity towards Tachykinin receptor 1
ChEMBL 720 21 2 7 7.5 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm960281e
44289219 169082 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 480 6 1 2 5.6 O=C(Cc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL416436 169082 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 480 6 1 2 5.6 O=C(Cc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
118722857 122969 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 376 7 2 5 1.6 CS(=O)(=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358421 122969 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 376 7 2 5 1.6 CS(=O)(=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
44333606 11921 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 7.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2Cl)c1 10.1016/S0960-894X(96)00563-X
CHEMBL105800 11921 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 7.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)cc2Cl)c1 10.1016/S0960-894X(96)00563-X
10342797 97664 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1Cl)c1ccccc1 10.1021/jm00035a006
CHEMBL23927 97664 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 432 7 2 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1Cl)c1ccccc1 10.1021/jm00035a006
24800925 94220 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 360 5 1 3 3.7 Brc1cncc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL2333645 94220 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 360 5 1 3 3.7 Brc1cncc(COCC2(c3ccccc3)CCNCC2)c1 10.1016/j.bmcl.2012.11.094
CHEMBL405795 219360 7 None - 0 Guinea pig 6.2 pIC50 = 6.2 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL None None None NC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a011
10458786 12195 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 504 5 0 3 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL107283 12195 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 504 5 0 3 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
44288934 161870 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 599 6 0 3 7.3 O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](N(Cc2ccnc3ccccc23)C(=O)C(F)(F)F)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL40189 161870 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 599 6 0 3 7.3 O=C(c1cc(Cl)cc(Cl)c1)N1CC[C@H](N(Cc2ccnc3ccccc23)C(=O)C(F)(F)F)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10087358 67114 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 320 4 1 3 3.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 10.1021/jm00006a011
CHEMBL174465 67114 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 320 4 1 3 3.3 O=C1OC(Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 10.1021/jm00006a011
21308490 108424 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 522 8 1 3 6.2 O=C([C@H](COCc1ccc(Cl)c(Cl)c1)NCc1ccccc1)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00319-9
CHEMBL299089 108424 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 522 8 1 3 6.2 O=C([C@H](COCc1ccc(Cl)c(Cl)c1)NCc1ccccc1)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00319-9
44346675 121032 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 320 4 1 3 3.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 10.1021/jm9700171
CHEMBL333039 121032 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 320 4 1 3 3.3 O=C1O[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1Cc1ccccc1 10.1021/jm9700171
44337704 174913 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 9 3 5 4.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=N)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL432979 174913 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 9 3 5 4.9 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=N)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
44297859 108494 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 11 1 5 5.5 CN(c1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)S(C)(=O)=O 10.1016/s0960-894x(98)00319-9
CHEMBL299528 108494 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsDisplacement of [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 603 11 1 5 5.5 CN(c1ccccc1C1CCN(C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)CC1)S(C)(=O)=O 10.1016/s0960-894x(98)00319-9
21994329 35694 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 463 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL137972 35694 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 463 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1cc(C)cc(C)c1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL2112246 216012 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
11724403 175324 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL435564 175324 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C\c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
10389807 103385 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(C(F)(F)F)c1)c1ccccc1 10.1021/jm00035a006
CHEMBL26336 103385 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 466 7 2 3 5.3 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cccc(C(F)(F)F)c1)c1ccccc1 10.1021/jm00035a006
CHEMBL411230 219653 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
44433785 153687 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 526 6 0 2 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(CC2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
CHEMBL392566 153687 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells
ChEMBL 526 6 0 2 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H]1CN(CC2CCCCC2)C[C@@H]1c1ccccc1 10.1016/j.bmcl.2007.08.028
68870858 131569 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 555 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642168 131569 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 555 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
18391053 173358 1 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 487 5 2 3 4.0 NCC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL42800 173358 1 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 487 5 2 3 4.0 NCC(=O)N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
19797458 40999 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL142638 40999 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1cccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
19797415 45015 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 475 8 0 3 7.3 c1ccc(Oc2cccc(COC3C4CCN(CC4)C3C(c3ccccc3)c3ccccc3)c2)cc1 10.1021/jm00024a007
CHEMBL146223 45015 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 475 8 0 3 7.3 c1ccc(Oc2cccc(COC3C4CCN(CC4)C3C(c3ccccc3)c3ccccc3)c2)cc1 10.1021/jm00024a007
44287481 169761 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 8 1 1 7.0 O=C(CC(c1ccccc1)c1ccccc1)NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
CHEMBL417522 169761 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 479 8 1 1 7.0 O=C(CC(c1ccccc1)c1ccccc1)NCCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(96)00280-6
10650263 32859 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
CHEMBL135572 32859 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).Binding affinity at Tachykinin receptor 1 by measuring its ability to inhibit [125I]BH-SP binding in human IM-9 cells (Lymphoblast cells).
ChEMBL 547 4 0 4 6.8 Cc1ccc(-c2c(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm980042m
44345147 118076 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2\CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL326613 118076 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2\CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
44297649 195491 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 649 9 1 6 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL50455 195491 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 649 9 1 6 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](CS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
10052114 172862 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 512 4 2 3 4.9 CNC(=O)N1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 10.1021/jm00006a011
CHEMBL425848 172862 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 512 4 2 3 4.9 CNC(=O)N1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)C1Cc1c[nH]c2ccccc12 10.1021/jm00006a011
10837320 42221 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 415 5 1 1 6.4 FC(F)(F)c1cc(CCCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL143813 42221 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 415 5 1 1 6.4 FC(F)(F)c1cc(CCCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL265573 217433 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C(=C\c1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
44384901 176683 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1 10.1016/0960-894X(96)00148-5
CHEMBL444086 176683 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1 10.1016/0960-894X(96)00148-5
44384986 136552 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 623 9 1 5 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1C 10.1016/0960-894X(96)00148-5
CHEMBL367528 136552 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 623 9 1 5 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1C 10.1016/0960-894X(96)00148-5
44411637 146058 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of human NK1 receptor expressed in U373MG cellsInhibition of human NK1 receptor expressed in U373MG cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccccc1F 10.1016/j.bmcl.2006.02.027
CHEMBL379097 146058 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of human NK1 receptor expressed in U373MG cellsInhibition of human NK1 receptor expressed in U373MG cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccccc1F 10.1016/j.bmcl.2006.02.027
44344195 170139 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 475 5 1 3 6.2 Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 10.1016/S0960-894X(96)00623-3
CHEMBL419232 170139 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the inhibitory potency against Neurokinin 1 NK1 receptorTested for the inhibitory potency against Neurokinin 1 NK1 receptor
ChEMBL 475 5 1 3 6.2 Cc1cc(C)cc(C(=O)N2C3CC(NCc4ccnc5ccccc45)CC2C(c2ccccc2)C3)c1 10.1016/S0960-894X(96)00623-3
10055415 113533 0 None - 3 Rat 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 113533 0 None - 3 Rat 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandTested for binding affinity against rat NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL418757 220018 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured for Tachykinin receptor 1Binding affinity was measured for Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@H]1NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm9800346
58993550 128844 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.7 Cn1nnnc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596453 128844 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 431 6 1 6 3.7 Cn1nnnc1-c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
44384677 138236 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 667 11 1 6 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC(C)C 10.1016/0960-894X(96)00148-5
CHEMBL369174 138236 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 667 11 1 6 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC(C)C 10.1016/0960-894X(96)00148-5
44413144 145997 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 465 8 2 3 4.4 CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(F)cc1 10.1016/j.bmcl.2006.04.045
CHEMBL378784 145997 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 465 8 2 3 4.4 CN(C)CCN[C@H](C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc(F)cc1 10.1016/j.bmcl.2006.04.045
54582277 67921 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 438 4 1 2 6.0 Cc1nccc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765491 67921 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 438 4 1 2 6.0 Cc1nccc(-c2ccccc2)c1C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
28558057 169828 2 None - 0 Human 5.2 pIC50 = 5.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 423 4 1 1 6.5 O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
CHEMBL41762 169828 2 None - 0 Human 5.2 pIC50 = 5.2 Binding
Affinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cellsAffinity for human NK1 receptor determined by displacement of [125I]- Substance P from human NK1 receptor in CHO cells
ChEMBL 423 4 1 1 6.5 O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(96)00280-6
24801627 94191 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 398 5 0 3 4.9 CN1CCC(COCc2cc(Cl)cc(C(F)(F)F)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333616 94191 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 398 5 0 3 4.9 CN1CCC(COCc2cc(Cl)cc(C(F)(F)F)n2)(c2ccccc2)CC1 10.1016/j.bmcl.2012.11.094
10695397 196384 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 463 6 1 4 4.7 O=C(O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
CHEMBL51477 196384 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled SP from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 463 6 1 4 4.7 O=C(O)CN1CCO[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1021/jm950654w
46884517 14864 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 643 7 0 4 8.0 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1091341 14864 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 643 7 0 4 8.0 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cnn(Cc4ccccc4)c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
10026200 11620 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 439 5 1 3 5.9 CCN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
CHEMBL104277 11620 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 439 5 1 3 5.9 CCN(Cc1ccccc1)C(=O)Nc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
44385575 66570 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 653 11 1 6 5.6 COc1cc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL172676 66570 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 653 11 1 6 5.6 COc1cc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
71583203 94996 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmc.2013.02.010
CHEMBL2347695 94996 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmc.2013.02.010
10473960 93057 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00006a012
CHEMBL23129 93057 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00006a012
10473960 93057 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23129 93057 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44415423 146032 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 432 5 1 2 5.9 O=C(O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL378984 146032 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 432 5 1 2 5.9 O=C(O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
71699787 131558 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 593 4 0 3 5.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642157 131558 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 593 4 0 3 5.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
19797468 44530 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL145801 44530 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.5 FC(F)(F)c1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
19003156 73915 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 3 3.6 CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm0311487
CHEMBL187554 73915 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 364 6 2 3 3.6 CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm0311487
10473960 93057 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00066a015
CHEMBL23129 93057 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cellsTested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
ChEMBL 364 6 2 3 3.6 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00066a015
15639109 170813 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 408 6 1 2 5.6 c1ccc(CN[C@H]2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL420876 170813 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [125I]Bolton-Hunter SP.
ChEMBL 408 6 1 2 5.6 c1ccc(CN[C@H]2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
44321046 213000 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 411 7 2 3 5.1 CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL86643 213000 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 411 7 2 3 5.1 CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44321046 213000 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 411 7 2 3 5.1 CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
CHEMBL86643 213000 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 411 7 2 3 5.1 CNc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00092a009
44321493 213018 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 480 7 1 3 6.4 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1021/jm00092a009
CHEMBL86746 213018 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandBinding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
ChEMBL 480 7 1 3 6.4 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1021/jm00092a009
10451098 18578 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 359 4 2 1 4.5 O=C(NCc1c[nH]c2ccccc12)N1C2CCC(C2)C1Cc1ccccc1 10.1016/S0960-894X(96)00570-7
CHEMBL118194 18578 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 359 4 2 1 4.5 O=C(NCc1c[nH]c2ccccc12)N1C2CCC(C2)C1Cc1ccccc1 10.1016/S0960-894X(96)00570-7
44307137 108888 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 489 4 0 4 5.1 COC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL302315 108888 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 489 4 0 4 5.1 COC(=O)C(=O)N1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
24783930 128852 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 459 6 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2Cl)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596461 128852 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 459 6 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccccc2Cl)c1 10.1016/j.bmcl.2015.04.098
10030004 118122 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 5 0 3 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL326889 118122 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 532 5 0 3 6.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)Cc1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
15391369 109605 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 518 6 2 2 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(C=Cc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL305509 109605 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 518 6 2 2 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(C=Cc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
44328389 114014 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 408 6 1 2 5.6 c1ccc(CNC2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
CHEMBL316842 114014 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 408 6 1 2 5.6 c1ccc(CNC2C3CC4CCC(C3)N4[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00044a002
4189 213701 96 None -27 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 213701 96 None -27 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 213701 96 None -27 34 Human 5.2 pIC50 = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
10405461 67113 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 348 4 1 3 3.9 Cc1cc(C)cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)c1 10.1021/jm00006a011
CHEMBL174464 67113 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 348 4 1 3 3.9 Cc1cc(C)cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)c1 10.1021/jm00006a011
2090 9543 25 None - 4 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
5311312 9543 25 None - 4 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
CHEMBL437797 9543 25 None - 4 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)81197-5
44384987 68128 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1cc(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL176769 68128 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 609 9 1 5 5.7 COc1cc(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
44289169 108265 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL297883 108265 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@@H](NCc3ccnc4ccccc34)C[C@@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
54585204 67937 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 478 4 1 4 5.7 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 10.1016/j.bmc.2011.02.031
CHEMBL1765505 67937 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 478 4 1 4 5.7 Cc1c(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(-c2ccccc2)cc2nncn12 10.1016/j.bmc.2011.02.031
10031310 11482 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 589 6 1 3 6.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(I)cc2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL103510 11482 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 589 6 1 3 6.5 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(I)cc2)c1 10.1016/S0960-894X(96)00563-X
10339539 116545 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.3 CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL323128 116545 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.3 CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 10.1016/0960-894X(95)00476-A
44276788 103271 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 550 8 1 3 7.3 O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1ccncc1 10.1016/0960-894X(95)00220-N
CHEMBL26251 103271 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 550 8 1 3 7.3 O=C(C[C@H]1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1)NCc1ccncc1 10.1016/0960-894X(95)00220-N
44319329 212749 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 389 4 1 2 5.3 FC(F)(F)c1cc(CO[C@H]2CCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
CHEMBL84588 212749 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Compound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cellsCompound was tested for the displacement of [ 1251] Substance P from hNK1 receptor in CHO cells
ChEMBL 389 4 1 2 5.3 FC(F)(F)c1cc(CO[C@H]2CCN[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80280-8
44306045 107443 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 583 9 2 7 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL292256 107443 0 None - 0 Guinea pig 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 583 9 2 7 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
9871754 12181 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
CHEMBL107172 12181 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 533 4 0 4 6.2 Cc1ccc(-c2c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c3ncccc23)cc1 10.1021/jm00016a014
21994328 37982 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL140086 37982 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 571 8 1 4 6.1 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
24784190 128863 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 469 6 1 4 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3c(c2)OCO3)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596472 128863 0 None - 0 Mongolian jird 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 469 6 1 4 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2ccc3c(c2)OCO3)c1 10.1016/j.bmcl.2015.04.098
9855000 27393 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL130834 27393 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.8 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CCCCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
44328400 114888 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 442 6 1 2 6.3 Clc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL319559 114888 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 442 6 1 2 6.3 Clc1ccccc1CNC1C2CC3CCC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
44415435 86916 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 5.3 NC(=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213359 86916 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 5.3 NC(=O)[C@@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44415469 174209 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL429715 174209 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.8 CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
11546759 95008 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
CHEMBL2347855 95008 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 445 5 0 2 6.3 CN1CCC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)CC1 10.1016/j.bmc.2013.02.010
21994352 126059 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 605 8 1 4 5.9 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2Cc3ccccc3C2)CC1 10.1021/jm000986n
CHEMBL343797 126059 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 605 8 1 4 5.9 COc1ccccc1C(CNC(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C2Cc3ccccc3C2)CC1 10.1021/jm000986n
10626865 64297 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 569 11 2 5 4.8 CSc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL166178 64297 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 569 11 2 5 4.8 CSc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
44328424 114085 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 454 7 1 4 5.2 COc1ccccc1CNC1C2CC3CCOC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
CHEMBL317297 114085 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandTested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
ChEMBL 454 7 1 4 5.2 COc1ccccc1CNC1C2CC3CCOC(C2)N3[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00044a002
46227360 209361 0 None 1 4 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611924 209361 0 None 1 4 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
10839068 125502 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 499 7 0 5 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3ncon3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
CHEMBL341745 125502 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 499 7 0 5 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCN(Cc3ncon3)CC2)cc(C(F)(F)F)c1 10.1021/jm980376b
24993312 186132 11 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 475 4 1 2 6.7 C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL473680 186132 11 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 475 4 1 2 6.7 C[C@@H](O[C@H]1CC[C@@H]2CNC[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
10436850 86421 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 524 8 3 4 3.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL2115107 86421 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 524 8 3 4 3.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
11546190 112577 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126960 112577 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 417 5 1 2 5.7 N[C@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
19098236 40807 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 525 6 0 2 8.1 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)C2CCCCC2)cc(C(F)(F)F)c1 10.1021/jm00024a007
CHEMBL142477 40807 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 525 6 0 2 8.1 FC(F)(F)c1cc(COC2C3CCN(CC3)C2C(c2ccccc2)C2CCCCC2)cc(C(F)(F)F)c1 10.1021/jm00024a007
44319082 174806 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 752 13 1 8 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL432183 174806 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 752 13 1 8 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
18669085 90151 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 529 7 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(-c4ccccc4)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21939 90151 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 529 7 1 3 7.1 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(-c4ccccc4)cc3)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
44306693 109125 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 568 9 2 6 3.1 COc1ccc(C[C@@H](NC(=O)C2C[C@@H](O)CN2C(=O)c2cn(C)c3ccccc23)C(=O)N(C)Cc2ccccc2)cc1 10.1021/jm00039a022
CHEMBL303750 109125 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 568 9 2 6 3.1 COc1ccc(C[C@@H](NC(=O)C2C[C@@H](O)CN2C(=O)c2cn(C)c3ccccc23)C(=O)N(C)Cc2ccccc2)cc1 10.1021/jm00039a022
44358476 37136 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 601 9 1 5 6.1 COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC 10.1021/jm000986n
CHEMBL139190 37136 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 601 9 1 5 6.1 COc1cccc(C(CNC(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCC(N3CCCCC3)CC2)c1OC 10.1021/jm000986n
44297629 197289 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL51794 197289 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 567 9 1 5 4.4 CS(=O)(=O)N1CC2(CCN(C(=O)[C@H](COCc3cccc(Cl)c3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
46884515 14597 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 553 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089532 14597 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 553 5 1 3 6.5 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cn[nH]c3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44456866 164749 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
CHEMBL408484 164749 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]L-703606 from human NK1 expressed in CHO cellsDisplacement of [125I]L-703606 from human NK1 expressed in CHO cells
ChEMBL 533 5 1 4 6.6 C[C@@H](O[C@@H]1[C@H](CO)N(C(=O)OC(C)(C)C)C[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2007.11.081
24993955 191084 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 517 4 0 2 7.0 CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL484134 191084 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 517 4 0 2 7.0 CC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL276294 217607 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)S(C)(=O)=O)C(N)=O 10.1021/jm00037a009
44415447 148330 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL384796 148330 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 403 4 1 2 5.5 N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44338640 174868 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 482 7 1 4 4.4 COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
CHEMBL432627 174868 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligandBinding affinity against human Tachykinin receptor 1 expressed in CHO cells using [3H]-substance P as the radioligand
ChEMBL 482 7 1 4 4.4 COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 10.1016/s0960-894x(02)00563-2
44321099 213004 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 426 7 0 3 5.4 COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL86659 213004 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 426 7 0 3 5.4 COc1ccccc1CN(C)[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm9700171
44368159 54968 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 5 4.6 CN(Cc1nn[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL155218 54968 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 459 8 1 5 4.6 CN(Cc1nn[nH]n1)[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
44346420 21077 0 None - 0 Guinea pig 7.2 pIC50 = 7.2 Binding
Compound was evaluated for its affinity to guinea pig Tachykinin receptor 1Compound was evaluated for its affinity to guinea pig Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
CHEMBL119990 21077 0 None - 0 Guinea pig 7.2 pIC50 = 7.2 Binding
Compound was evaluated for its affinity to guinea pig Tachykinin receptor 1Compound was evaluated for its affinity to guinea pig Tachykinin receptor 1
ChEMBL 473 5 0 3 4.8 COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(c1ccccc1)(c1ccccc1)CC[S+]2[O-] 10.1016/S0960-894X(01)80177-3
44288758 107888 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL295122 107888 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Compound was tested for inhibition of NK1 receptor from gerbil midbrainCompound was tested for inhibition of NK1 receptor from gerbil midbrain
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3cnc4ccccc4c3)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
24785191 128849 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 432 6 1 4 5.7 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nccs2)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596458 128849 0 None - 0 Mongolian jird 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 432 6 1 4 5.7 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-c2nccs2)c1 10.1016/j.bmcl.2015.04.098
44294423 18811 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 414 4 0 5 5.0 CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
53817703 18811 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 414 4 0 5 5.0 CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183414 18811 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 414 4 0 5 5.0 CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL295686 18811 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 414 4 0 5 5.0 CCn1c(/C=C/C=C2\Sc3ccccc3N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
15037919 126405 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 396 6 1 2 5.4 Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL346633 126405 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 396 6 1 2 5.4 Cc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
71541376 94205 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 382 5 0 3 4.4 CN1CCC(COCc2cc(C(F)(F)F)ccn2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333630 94205 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 382 5 0 3 4.4 CN1CCC(COCc2cc(C(F)(F)F)ccn2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
24785445 128842 0 None - 0 Mongolian jird 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 485 6 1 6 4.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-n2nnnc2C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
CHEMBL3596451 128842 0 None - 0 Mongolian jird 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 485 6 1 6 4.5 FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(-n2nnnc2C(F)(F)F)c1 10.1016/j.bmcl.2015.04.098
10668476 106224 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 396 7 1 2 5.1 c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
CHEMBL282996 106224 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO CellsDisplacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells
ChEMBL 396 7 1 2 5.1 c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1016/S0960-894X(00)80349-2
9957036 170937 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 485 6 1 3 6.4 O=C(c1ccc2ccccc2c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
CHEMBL42103 170937 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 485 6 1 3 6.4 O=C(c1ccc2ccccc2c1)N1CC[C@H](NCc2ccnc3ccccc23)C[C@H]1Cc1ccccc1 10.1016/0960-894X(96)00287-9
10668476 106224 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 396 7 1 2 5.1 c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL282996 106224 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 396 7 1 2 5.1 c1ccc(CCN[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
44380709 127172 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 322 5 1 3 3.6 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/S0960-894X(01)80859-3
CHEMBL353416 127172 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 322 5 1 3 3.6 COc1ccccc1CN[C@@H]1C2CCN(CC2)[C@H]1c1ccccc1 10.1016/S0960-894X(01)80859-3
44297359 199126 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 10.1016/s0960-894x(98)00320-5
CHEMBL52070 199126 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 563 10 1 6 3.7 COc1cccc(CNC(COCc2ccccc2)C(=O)N2CCC3(CC2)CN(S(C)(=O)=O)c2ccccc23)c1 10.1016/s0960-894x(98)00320-5
44345156 120884 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2/CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
CHEMBL332759 120884 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Tested for the binding affinity against neurokinin NK1 receptorTested for the binding affinity against neurokinin NK1 receptor
ChEMBL 478 5 1 2 7.4 Cc1cc(C)cc(/C(F)=C2/CCC(NC(=O)c3ccnc4ccccc34)CC2Cc2ccccc2)c1 10.1016/S0960-894X(96)00624-5
10674743 116995 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL323762 116995 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
100951644 176413 16 None - 0 Human 4.2 pIC50 = 4.2 Binding
Inhibition of NK1R (unknown origin)Inhibition of NK1R (unknown origin)
ChEMBL 411 7 2 9 2.3 CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(c3cccnn3)C2)s1)c1ccccc1 10.1021/acs.jmedchem.9b00260
CHEMBL4437106 176413 16 None - 0 Human 4.2 pIC50 = 4.2 Binding
Inhibition of NK1R (unknown origin)Inhibition of NK1R (unknown origin)
ChEMBL 411 7 2 9 2.3 CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(c3cccnn3)C2)s1)c1ccccc1 10.1021/acs.jmedchem.9b00260
24889283 15203 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 597 6 0 5 7.3 CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
CHEMBL1093595 15203 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 597 6 0 5 7.3 CC(C)c1noc(C2=CC(=O)N3C[C@H](O[C@H](C)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H](c4ccc(F)cc4)C3C2)n1 10.1016/j.bmcl.2010.01.120
44289218 170488 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 481 5 2 2 6.0 O=C(Nc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
CHEMBL42050 170488 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 481 5 2 2 6.0 O=C(Nc1ccccc1)N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1 10.1016/0960-894X(96)00287-9
44233184 201547 0 None -12 4 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL538131 201547 0 None -12 4 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
15037920 52503 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 430 7 1 2 5.8 Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL153042 52503 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 430 7 1 2 5.8 Clc1ccccc1CCN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44363017 44077 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 409 4 0 5 5.7 CCN1/C(=C/C=C/c2nc3nc4ccccc4nc3n2CC)C(C)(C)c2ccccc21 10.1021/jm00024a007
CHEMBL145407 44077 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]SP binding in rat brain membranesInhibition of [3H]SP binding in rat brain membranes
ChEMBL 409 4 0 5 5.7 CCN1/C(=C/C=C/c2nc3nc4ccccc4nc3n2CC)C(C)(C)c2ccccc21 10.1021/jm00024a007
44358982 37438 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 548 10 4 5 4.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NS(C)(=O)=O)c1)c1ccccc1 10.1021/jm00022a010
CHEMBL139464 37438 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 548 10 4 5 4.6 C[C@H](NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OCc1cccc(NS(C)(=O)=O)c1)c1ccccc1 10.1021/jm00022a010
42639649 177524 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 553 5 0 4 7.4 C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
CHEMBL445239 177524 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 553 5 0 4 7.4 C[C@@H](O[C@H]1CC[C@@H]2CN(c3cnccn3)C[C@H]2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm8016514
44370352 58268 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 683 18 1 5 7.5 CCCCCN(CCCCC)C(=O)[C@@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
CHEMBL158255 58268 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 683 18 1 5 7.5 CCCCCN(CCCCC)C(=O)[C@@H]1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/0960-894X(95)00080-D
44212282 68061 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1ccccc1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL176682 68061 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPBinding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
ChEMBL 579 8 1 4 5.7 COc1ccccc1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
19960248 176863 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm980376b
CHEMBL444339 176863 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1ccc(COCC2(c3ccccc3)CCNCC2)cc1 10.1021/jm980376b
10452352 135303 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 380 6 1 5 3.3 COc1cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)cc(OC)c1 10.1021/jm00006a011
CHEMBL366753 135303 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.
ChEMBL 380 6 1 5 3.3 COc1cc(CN2C(=O)OC(Cc3c[nH]c4ccccc34)C2=O)cc(OC)c1 10.1021/jm00006a011
76336391 112582 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 471 7 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126965 112582 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 471 7 1 2 6.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(NC3CC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
71541372 94223 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 384 5 1 3 4.6 FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333648 94223 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 384 5 1 3 4.6 FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)n1 10.1016/j.bmcl.2012.11.094
11634999 94992 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 521 7 0 2 7.9 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
CHEMBL2347691 94992 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 521 7 0 2 7.9 FC(F)(F)c1cc(COC[C@@]2(c3ccccc3)CCCN(Cc3ccccc3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.02.010
131871 126306 6 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL345711 126306 6 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 450 6 1 2 6.1 FC(F)(F)c1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44359010 36772 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 512 9 4 4 5.2 CC(=O)Nc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/jm00022a010
CHEMBL138883 36772 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 512 9 4 4 5.2 CC(=O)Nc1cccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)c1 10.1021/jm00022a010
23294208 103923 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 590 8 1 4 6.8 O=C1CCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
CHEMBL26790 103923 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 590 8 1 4 6.8 O=C1CCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
44299310 103510 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 351 7 1 2 5.0 NC(COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL264376 103510 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 351 7 1 2 5.0 NC(COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL436706 220465 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(C)C)C(N)=O 10.1016/S0960-894X(01)80229-8
44346497 21315 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 351 7 1 2 5.0 N[C@H](COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
CHEMBL120286 21315 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 351 7 1 2 5.0 N[C@H](COCc1cccc(Cl)c1)C(c1ccccc1)c1ccccc1 10.1021/jm9700171
10407632 108601 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 383 6 0 2 5.5 c1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
CHEMBL30029 108601 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 383 6 0 2 5.5 c1ccc(CO[C@H]2C3CCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9700171
10736544 109532 2 None - 0 Human 6.1 pIC50 = 6.1 Binding
Concentration required for 50% inhibition of neurokinin-1 receptorConcentration required for 50% inhibition of neurokinin-1 receptor
ChEMBL 349 6 2 2 2.9 CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 10.1016/S0960-894X(97)00353-3
CHEMBL305094 109532 2 None - 0 Human 6.1 pIC50 = 6.1 Binding
Concentration required for 50% inhibition of neurokinin-1 receptorConcentration required for 50% inhibition of neurokinin-1 receptor
ChEMBL 349 6 2 2 2.9 CC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 10.1016/S0960-894X(97)00353-3
10520658 105423 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL277260 105423 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
10025594 97665 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 428 8 2 4 4.3 COc1cccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
CHEMBL23928 97665 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 428 8 2 4 4.3 COc1cccc(COC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccc2)c1 10.1021/jm00035a006
24799365 94194 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 425 7 1 4 4.9 CCNc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333619 94194 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 425 7 1 4 4.9 CCNc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
9852376 105878 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 639 8 0 4 6.6 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
CHEMBL280789 105878 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 639 8 0 4 6.6 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
44385121 67942 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 350 7 2 2 4.0 CC(=O)N[C@H](COCc1cc(C)cc(C)c1)Cc1c[nH]c2ccccc12 10.1021/jm00006a012
CHEMBL176557 67942 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 350 7 2 2 4.0 CC(=O)N[C@H](COCc1cc(C)cc(C)c1)Cc1c[nH]c2ccccc12 10.1021/jm00006a012
44299753 202421 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 443 7 1 2 5.0 NC(COCc1cccc(I)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
CHEMBL55635 202421 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 443 7 1 2 5.0 NC(COCc1cccc(I)c1)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80531-X
44287861 168518 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 472 5 1 4 4.4 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL41375 168518 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 472 5 1 4 4.4 CN(C)c1ccccc1CC(=O)N1C[C@@H]2[C@H](C1)[C@@H](O)CSC2(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL415600 219973 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Concentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomesConcentration required to inhibit the specific binding of [125I]BH-SP to Neurokinin-1 (NK-1) receptor in rat brain synaptosomes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
56661421 73222 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817831 73222 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852028 73222 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 421 6 0 3 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)cc1 10.1016/j.bmc.2011.07.014
44312000 211458 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 8 3 3 4.6 CC(=O)NC1(c2ccccc2)CCN(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N(C)Cc2ccccc2)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73839 211458 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 8 3 3 4.6 CC(=O)NC1(c2ccccc2)CCN(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N(C)Cc2ccccc2)CC1 10.1016/s0960-894x(98)00395-3
14999557 109402 0 None - 0 Guinea pig 6.1 pIC50 = 6.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL304246 109402 0 None - 0 Guinea pig 6.1 pIC50 = 6.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
68870105 131565 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642164 131565 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
16755281 183578 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 439 6 1 7 3.9 COc1cc(CNC(=O)c2c(-c3ccccc3)c3ccccc3n3nnnc23)cc(OC)c1 10.1016/j.bmc.2008.05.067
CHEMBL460684 183578 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 439 6 1 7 3.9 COc1cc(CNC(=O)c2c(-c3ccccc3)c3ccccc3n3nnnc23)cc(OC)c1 10.1016/j.bmc.2008.05.067
44297698 201769 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cc(Cl)cc(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL54717 201769 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3cc(Cl)cc(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
68932311 131571 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 565 5 1 4 4.3 CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642170 131571 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 565 5 1 4 4.3 CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
44322724 213076 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 474 6 1 3 5.2 Cc1cccc(CN(C(=O)COc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
CHEMBL87066 213076 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [3H]-substance P displacement.
ChEMBL 474 6 1 3 5.2 Cc1cccc(CN(C(=O)COc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2CCNCC2)c1 10.1016/s0960-894x(01)00727-2
24800577 94203 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 448 6 1 5 3.7 CN1CCN(c2cc(C(F)(F)F)cc(COCC3(c4ccccc4)CCNCC3)n2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333628 94203 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 448 6 1 5 3.7 CN1CCN(c2cc(C(F)(F)F)cc(COCC3(c4ccccc4)CCNCC3)n2)CC1 10.1016/j.bmcl.2012.11.094
15755302 109096 0 None - 0 Guinea pig 6.1 pIC50 = 6.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 614 16 4 8 2.9 CSCC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL303543 109096 0 None - 0 Guinea pig 6.1 pIC50 = 6.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 614 16 4 8 2.9 CSCC[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
44458869 18758 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 420 2 0 2 6.2 CCn1c2[n+](c3cc4ccccc4cc31)CCC2=C/C=C1\N(C)c2ccccc2C1(C)C 10.1021/jm00085a015
CHEMBL1183106 18758 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 420 2 0 2 6.2 CCn1c2[n+](c3cc4ccccc4cc31)CCC2=C/C=C1\N(C)c2ccccc2C1(C)C 10.1021/jm00085a015
CHEMBL280339 18758 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of Tachykinin receptor 1 of rat forebrain tissueInhibition of Tachykinin receptor 1 of rat forebrain tissue
ChEMBL 420 2 0 2 6.2 CCn1c2[n+](c3cc4ccccc4cc31)CCC2=C/C=C1\N(C)c2ccccc2C1(C)C 10.1021/jm00085a015
44375286 126888 0 None - 0 Guinea pig 5.1 pIC50 = 5.1 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL351059 126888 0 None - 0 Guinea pig 5.1 pIC50 = 5.1 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
9827668 119049 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 420 8 2 3 4.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
CHEMBL329105 119049 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Affinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cellsAffinity towards hNK1 receptor by displacement of [125I]- Substance P from hNK1 receptor expressed in CHO cells
ChEMBL 420 8 2 3 4.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/s0960-894x(97)10163-9
11647974 112588 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 445 6 0 2 6.3 CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
CHEMBL3126970 112588 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 445 6 0 2 6.3 CN(C)C1CCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2014.01.036
9938657 66996 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
CHEMBL174038 66996 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 565 8 2 3 5.9 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CCN(CC1)CC2 10.1021/jm00006a012
9827668 119049 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 420 8 2 3 4.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL329105 119049 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 420 8 2 3 4.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/0960-894X(95)00476-A
44458598 105624 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 489 6 1 4 5.7 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00035a006
CHEMBL278849 105624 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 489 6 1 4 5.7 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm00035a006
107686 10152 41 None 15 2 Rat 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
3522 10152 41 None 15 2 Rat 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
CHEMBL131171 10152 41 None 15 2 Rat 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on rat brain membranes.
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00277-Z
44274331 89235 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1cccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)c1 10.1016/s0960-894x(01)00183-4
CHEMBL21759 89235 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1cccc(-c2[nH]c3ccc(C)cc3c2CCC(=O)N2CCN(c3ccccc3OC)CC2)c1 10.1016/s0960-894x(01)00183-4
44433799 95443 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 4 5.8 Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
CHEMBL235882 95443 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]SP from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 582 5 0 4 5.8 Cc1cnc(C(=O)N2C[C@H](c3ccc(F)cc3C)[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)cn1 10.1016/j.bmcl.2007.08.028
44306000 107660 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 494 8 2 3 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL293675 107660 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 494 8 2 3 3.8 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1CCN1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44370925 126391 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 654 17 1 4 7.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
CHEMBL346485 126391 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cellsInhibition of [125I]-substance P binding to human neurokinin-1 (hNK-1) receptor in CHO cells
ChEMBL 654 17 1 4 7.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)NCCCN(CC)CC)C1 10.1016/0960-894X(95)00080-D
132837 9018 55 None 18 5 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
9461 9018 55 None 18 5 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
CHEMBL22870 9018 55 None 18 5 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm00006a012
58993629 128881 0 None - 0 Mongolian jird 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 451 6 1 4 5.5 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)nc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596490 128881 0 None - 0 Mongolian jird 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 451 6 1 4 5.5 N#Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)nc1 10.1016/j.bmcl.2015.04.098
24888772 14788 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090752 14788 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccncc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44319307 113324 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL314119 113324 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44415399 86829 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 487 6 0 3 6.1 FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCOCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.035
CHEMBL212978 86829 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 487 6 0 3 6.1 FC(F)(F)c1cc(CO[C@H]2CC[C@@H](CN3CCOCC3)[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.06.035
44415449 87040 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL213908 87040 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 460 7 2 3 4.6 NC(=O)CN[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
44290030 180317 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 527 10 2 5 4.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)Cc1ccc2c(c1)OCCO2)C(C)=O 10.1016/s0960-894x(01)00250-5
CHEMBL45316 180317 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 527 10 2 5 4.3 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)Cc1ccc2c(c1)OCCO2)C(C)=O 10.1016/s0960-894x(01)00250-5
19797439 43660 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 8 0 4 5.5 COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 10.1021/jm00024a007
CHEMBL145077 43660 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 8 0 4 5.5 COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 10.1021/jm00024a007
10577745 63918 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 514 11 1 5 3.6 COc1ccccc1CN(CC(Cc1ccccc1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL164563 63918 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 514 11 1 5 3.6 COc1ccccc1CN(CC(Cc1ccccc1)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
24782913 128868 0 None - 0 Mongolian jird 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
CHEMBL3596477 128868 0 None - 0 Mongolian jird 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 439 6 1 2 6.5 Cc1ccc(-c2cc(COCC3(c4ccccc4)CCNCC3)cc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2015.04.098
57402686 78380 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 3.8 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL1963297 78380 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 3.8 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
CHEMBL3217199 78380 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 380 6 2 4 3.8 COc1ccc(OC(F)(F)F)cc1CN[C@H]1CCNC[C@H]1c1ccccc1 10.1016/j.bmc.2011.08.070
10053175 11641 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 546 4 0 3 7.1 Cc1cc2c(-c3ccccc3)c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
CHEMBL104370 11641 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 546 4 0 3 7.1 Cc1cc2c(-c3ccccc3)c(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)n(C)c(=O)c2cc1C 10.1021/jm00016a014
44319223 113882 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 669 11 1 7 5.7 COc1cccc(C2(C(N)=O)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)c1 10.1016/S0960-894X(97)10013-0
CHEMBL315982 113882 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 669 11 1 7 5.7 COc1cccc(C2(C(N)=O)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)c1 10.1016/S0960-894X(97)10013-0
10202046 127839 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL356912 127839 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandBinding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligand
ChEMBL 416 6 1 2 5.7 Clc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
46884471 14521 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1089062 14521 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 564 5 0 3 7.2 C[C@@H](O[C@H]1CN2C(=O)C=C(c3cccnc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44352062 25706 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL128586 25706 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 573 3 0 4 7.1 Cc1ccc(-c2c3n(c(=O)c4ncccc24)CC[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
44319355 112299 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL312173 112299 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
71541473 94181 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 450 6 0 3 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3(C)C)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
CHEMBL2333607 94181 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 450 6 0 3 5.9 CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3(C)C)n2)(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.11.094
107686 10152 41 None - 2 Mouse 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
3522 10152 41 None - 2 Mouse 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL131171 10152 41 None - 2 Mouse 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1021/jm950616c
44319308 113155 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL313931 113155 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44274181 85013 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 557 7 1 4 6.7 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(OC(F)(F)F)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21062 85013 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 557 7 1 4 6.7 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3ccc(OC(F)(F)F)cc23)CC1 10.1016/s0960-894x(01)00182-2
44358475 37134 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 613 7 0 5 6.2 CN(CC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
CHEMBL139189 37134 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 613 7 0 5 6.2 CN(CC(c1ccc2c(c1)OCCO2)N1CCC(N2CCCCC2)CC1)C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm000986n
10063954 105508 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm9700171
CHEMBL277918 105508 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm9700171
44297484 202782 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 533 9 1 5 3.7 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL56003 202782 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 533 9 1 5 3.7 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
18986937 174936 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 369 5 1 2 5.5 Cc1cc(C)cc(COCC(N)C2c3ccccc3C=Cc3ccccc32)c1 10.1016/S0960-894X(00)80063-3
CHEMBL433107 174936 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 369 5 1 2 5.5 Cc1cc(C)cc(COCC(N)C2c3ccccc3C=Cc3ccccc32)c1 10.1016/S0960-894X(00)80063-3
68930433 131567 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 583 4 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642166 131567 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 583 4 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
19797417 44090 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL145414 44090 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 417 6 0 2 6.2 Clc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
10099318 63961 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL164912 63961 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(C2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
14986135 170180 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL419500 170180 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
44337620 116516 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 595 9 2 5 5.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL322976 116516 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 595 9 2 5 5.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CCCN1/C(S)=N/c1ccccc1[N+](=O)[O-] 10.1021/jm970499g
9979913 115248 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 426 6 0 4 5.5 COc1ccccc1CN(C)Cc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
CHEMBL319932 115248 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 426 6 0 4 5.5 COc1ccccc1CN(C)Cc1c(-c2ccccc2)c2cc(C)c(C)cc2c(=O)n1C 10.1021/jm00016a014
104974 10248 31 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
2111 10248 31 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
3481 10248 31 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
CHEMBL308148 10248 31 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
DB06660 10248 31 None -1202 7 Human 6.1 pIC50 = 6.1 Binding
Inhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK1 (Neurokinin 1) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
CHEMBL334721 218178 1 None - 3 Human 6.1 pIC50 = 6.1 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/S0960-894X(96)00570-7
44358520 37144 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 8 1 3 5.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
CHEMBL139198 37144 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 555 8 1 3 5.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)NCC(Cc1ccccc1)N1CCC(N2CCCCC2)CC1 10.1021/jm000986n
44346693 22175 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 421 9 1 2 7.1 Cc1cc(C)cc(COC[C@@H](Nc2ccccc2)C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
CHEMBL121480 22175 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 421 9 1 2 7.1 Cc1cc(C)cc(COC[C@@H](Nc2ccccc2)C(c2ccccc2)c2ccccc2)c1 10.1021/jm9700171
44366601 49200 11 None - 0 Guinea pig 5.1 pIC50 = 5.1 Binding
Binding affinity towards NK-1 receptor in guinea pig cerebral cortex using [125I]-Bolton-Hunter substance P as radioligand; Value ranges from 7.3-8.8 uMBinding affinity towards NK-1 receptor in guinea pig cerebral cortex using [125I]-Bolton-Hunter substance P as radioligand; Value ranges from 7.3-8.8 uM
ChEMBL 323 4 0 3 3.5 O=C1CCN(C(=O)OCc2ccccc2)CC1Cc1ccccc1 10.1016/0960-894X(94)80030-8
CHEMBL149905 49200 11 None - 0 Guinea pig 5.1 pIC50 = 5.1 Binding
Binding affinity towards NK-1 receptor in guinea pig cerebral cortex using [125I]-Bolton-Hunter substance P as radioligand; Value ranges from 7.3-8.8 uMBinding affinity towards NK-1 receptor in guinea pig cerebral cortex using [125I]-Bolton-Hunter substance P as radioligand; Value ranges from 7.3-8.8 uM
ChEMBL 323 4 0 3 3.5 O=C1CCN(C(=O)OCc2ccccc2)CC1Cc1ccccc1 10.1016/0960-894X(94)80030-8
104943 62160 39 None 1862 3 Human 4.1 pIC50 = 4.1 Binding
Binding potency against SP receptor (from ref. 1)Binding potency against SP receptor (from ref. 1)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
CHEMBL16192 62160 39 None 1862 3 Human 4.1 pIC50 = 4.1 Binding
Binding potency against SP receptor (from ref. 1)Binding potency against SP receptor (from ref. 1)
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80246-2
44346200 21185 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(CO[C@@H]2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1021/jm9700171
CHEMBL120038 21185 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(CO[C@@H]2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1021/jm9700171
44299876 169956 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 435 10 1 2 6.8 Cc1cc(C)cc(COCC(NCc2ccccc2)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL418114 169956 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 435 10 1 2 6.8 Cc1cc(C)cc(COCC(NCc2ccccc2)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
44274392 84866 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1ccccc1-c1[nH]c2ccc(C)cc2c1CCC(=O)N1CCN(c2ccccc2OC)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21018 84866 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 483 7 1 4 5.4 COc1ccccc1-c1[nH]c2ccc(C)cc2c1CCC(=O)N1CCN(c2ccccc2OC)CC1 10.1016/s0960-894x(01)00183-4
22293476 86480 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 592 7 1 2 8.7 Fc1ccc(C2CCN([C@H]3CC[C@@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
CHEMBL2115450 86480 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 592 7 1 2 8.7 Fc1ccc(C2CCN([C@H]3CC[C@@](CNCc4cc(C(F)(F)F)cc(C(F)(F)F)c4)(c4ccccc4)CC3)CC2)cc1 10.1016/s0960-894x(02)00249-4
44337569 15992 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 597 9 2 5 5.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL110558 15992 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 597 9 2 5 5.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
10520658 105423 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL277260 105423 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cellsBinding affinity towards wild type human Wild-type tachykinin receptor 1 expressed in Chinese hamster ovary cells
ChEMBL 333 4 0 2 5.0 Cc1cc(C)cc(COC2/C(=C/c3ccccc3)N3CCC2CC3)c1 10.1016/0960-894X(95)00205-8
CHEMBL2369630 216424 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
9851211 11971 33 None - 0 Human 4.1 pIC50 = 4.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL106092 11971 33 None - 0 Human 4.1 pIC50 = 4.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
44287606 107287 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 470 5 0 4 4.6 CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL291146 107287 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 470 5 0 4 4.6 CN(C)c1ccccc1CC(=O)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
10344874 126928 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assayIn vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
CHEMBL351387 126928 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assayIn vitro binding affinity against Tachykinin receptor 1 in rabbit whole brain membranes using [3H][Sar9Met(O2)]-SP binding assay
ChEMBL 475 7 3 5 4.6 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(01)00044-0
10907460 16600 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against tachykinin receptor 1Binding affinity against tachykinin receptor 1
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL113956 16600 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity against tachykinin receptor 1Binding affinity against tachykinin receptor 1
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
10548166 41874 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1ccccc1COCC1(c2ccccc2)CCNCC1 10.1021/jm980376b
CHEMBL143377 41874 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 349 5 1 2 4.5 FC(F)(F)c1ccccc1COCC1(c2ccccc2)CCNCC1 10.1021/jm980376b
68928720 131575 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 609 5 1 4 4.4 CN(C(=O)c1ccc(Br)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642174 131575 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 609 5 1 4 4.4 CN(C(=O)c1ccc(Br)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
10454303 12257 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 411 3 2 3 5.8 Cc1cccc(NC(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 10.1021/jm00016a014
CHEMBL107619 12257 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 411 3 2 3 5.8 Cc1cccc(NC(=O)Nc2c(-c3ccccc3)c3cc(C)c(C)cc3c(=O)n2C)c1 10.1021/jm00016a014
44458353 106380 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(95)00205-8
CHEMBL283979 106380 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
ChEMBL 335 5 0 2 4.5 Cc1cc(C)cc(CO[C@H]2C3CCN(CC3)[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(95)00205-8
44307090 107486 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 461 6 1 3 5.5 O=C(O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
CHEMBL292496 107486 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cellsDisplacement of [125I]- Substance P from human Neurokinin 1 (hNK1) receptor expressed in CHO cells
ChEMBL 461 6 1 3 5.5 O=C(O)CN1CCC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/0960-894X(95)00009-I
21955298 86481 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2115451 86481 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
ChEMBL 606 6 1 2 8.2 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@]1(c2ccccc2)CC[C@@H](N2CCC(c3ccc(F)cc3)CC2)CC1 10.1016/s0960-894x(02)00249-4
CHEMBL2369607 216419 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
10840161 175048 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 539 12 2 5 4.5 CCN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
CHEMBL433906 175048 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 539 12 2 5 4.5 CCN(Cc1ccccc1OC)CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1 10.1021/jm950616c
9832198 113532 0 None 100 3 Human 7.1 pIC50 = 7.1 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 113532 0 None 100 3 Human 7.1 pIC50 = 7.1 Binding
Tested for binding affinity against human NK-1 receptorTested for binding affinity against human NK-1 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44294408 18022 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 434 4 0 4 5.2 CCn1c(/C=C/C=C2\C3C=CCc4cccc(c43)N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1178974 18022 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 434 4 0 4 5.2 CCn1c(/C=C/C=C2\C3C=CCc4cccc(c43)N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL52114 18022 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 434 4 0 4 5.2 CCn1c(/C=C/C=C2\C3C=CCc4cccc(c43)N2C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
44294305 18812 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 510 8 0 6 5.6 CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 10.1021/jm00109a034
74972643 18812 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 510 8 0 6 5.6 CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183417 18812 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 510 8 0 6 5.6 CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL295781 18812 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligandBinding affinity for tachykinin receptor 1 from rat forebrain tissue, [125I]-BH-SP as radioligand
ChEMBL 510 8 0 6 5.6 CCOC(=O)CCC[n+]1c(/C=C/C=C2/N(C)c3ccccc3C2(C)C)n(CC)c2nc3ccccc3nc21 10.1021/jm00109a034
21994241 36540 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 469 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1ccc(Cl)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
CHEMBL138695 36540 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against Tachykinin receptor 1Inhibitory activity against Tachykinin receptor 1
ChEMBL 469 8 1 4 4.7 COc1ccccc1C(CNC(=O)Cc1ccc(Cl)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm000986n
71458099 86366 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2114398 86366 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesIn vitro inhibition of [3H]Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranes
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
44348676 24721 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 441 1 1 4 5.8 C=C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
CHEMBL126009 24721 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.Inhibition of [125]I-Bolton Hunter Substance P([125]I-BHSP) binding to standard Tachykinin receptor 1 from rat forebrain membranes.
ChEMBL 441 1 1 4 5.8 C=C[C@]1(O)CCC2C3CCC4Cc5nc6nc7ccccc7n6cc5C[C@]4(C)C3CC[C@@]21C 10.1021/jm00080a025
19797445 126216 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL344970 126216 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
44383265 127298 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 456 8 1 4 5.5 COc1ccc(CN[C@H]2C3CCCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c(OC)c1 10.1016/S0960-894X(00)80693-9
CHEMBL354542 127298 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Compound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cellsCompound was evaluated for the inhibition of binding of [3H]SP in human IM-9 cells
ChEMBL 456 8 1 4 5.5 COc1ccc(CN[C@H]2C3CCCN(CC3)[C@H]2C(c2ccccc2)c2ccccc2)c(OC)c1 10.1016/S0960-894X(00)80693-9
10408564 12755 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 398 5 1 4 4.1 COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
CHEMBL108010 12755 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cellsInhibition of [125I]-BH-Substance P binding to tachykinin receptor 1 in human IM-9 cells
ChEMBL 398 5 1 4 4.1 COc1ccccc1CNC(=O)c1c(-c2ccccc2)c2ccccc2c(=O)n1C 10.1021/jm00016a014
10474902 95460 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 380 6 2 4 3.8 COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
CHEMBL23597 95460 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance PBinding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
ChEMBL 380 6 2 4 3.8 COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C)cc(C)c1 10.1021/jm00035a006
44299830 203456 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 417 3 1 3 4.9 FC(F)(F)c1cc(C2OC2[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
CHEMBL56458 203456 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO CellsBinding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
ChEMBL 417 3 1 3 4.9 FC(F)(F)c1cc(C2OC2[C@@H]2OCCN[C@@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/S0960-894X(01)80534-5
44274326 88327 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 457 6 1 3 5.3 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21612 88327 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 457 6 1 3 5.3 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3)[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00182-2
58993640 128840 0 None - 0 Mongolian jird 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 393 7 1 7 2.8 COc1ccc(-n2nnnc2C)cc1COCC1(c2ccccc2)CCNCC1 10.1016/j.bmcl.2015.04.098
CHEMBL3596449 128840 0 None - 0 Mongolian jird 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
ChEMBL 393 7 1 7 2.8 COc1ccc(-n2nnnc2C)cc1COCC1(c2ccccc2)CCNCC1 10.1016/j.bmcl.2015.04.098
2090 9543 25 None - 4 Rat 6.1 pIC50 = 6.1 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
5311312 9543 25 None - 4 Rat 6.1 pIC50 = 6.1 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
CHEMBL437797 9543 25 None - 4 Rat 6.1 pIC50 = 6.1 Binding
Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandTested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligand
ChEMBL None None None None 10.1016/S0960-894X(01)80229-8
44297523 107469 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 651 9 1 6 4.2 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NS(=O)(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL292404 107469 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 651 9 1 6 4.2 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NS(=O)(=O)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44288770 166591 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 557 7 1 3 7.6 FC(F)(F)c1cc(CN2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(96)00287-9
CHEMBL41057 166591 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 557 7 1 3 7.6 FC(F)(F)c1cc(CN2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(96)00287-9
10408912 103184 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 404 4 0 2 6.2 FC(F)(F)c1cc(CO[C@H]2CCCO[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
CHEMBL26193 103184 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cellsBinding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells
ChEMBL 404 4 0 2 6.2 FC(F)(F)c1cc(CO[C@H]2CCCO[C@H]2c2ccccc2)cc(C(F)(F)F)c1 10.1016/0960-894X(95)00220-N
44274534 105735 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3Br)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL279726 105735 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 531 6 1 3 6.2 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccccc3Br)[nH]c3ccc(C)cc23)CC1 10.1016/s0960-894x(01)00183-4
46884431 14827 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 563 5 0 2 7.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1091043 14827 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 563 5 0 2 7.8 C[C@@H](O[C@H]1CN2C(=O)C=C(c3ccccc3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
54581461 68037 0 None -2089 4 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
CHEMBL1766207 68037 0 None -2089 4 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
44276792 105907 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 604 8 1 4 6.5 O=C1CCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
CHEMBL281019 105907 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Compound was evaluated for affinity towards human Neurokinin NK1 receptorCompound was evaluated for affinity towards human Neurokinin NK1 receptor
ChEMBL 604 8 1 4 6.5 O=C1CCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
44297685 107855 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3c(Cl)cccc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
CHEMBL294843 107855 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Ability to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cellsAbility to displace [125I]-substance P from hNK1 receptor in chinese hamster ovarian (CHO) cells
ChEMBL 601 9 1 5 5.0 CS(=O)(=O)N1CC2(CCN(C(=O)C(COCc3ccccc3)NCc3c(Cl)cccc3Cl)CC2)c2ccccc21 10.1016/s0960-894x(98)00320-5
44334072 11867 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 7.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)c(Cl)c2)c1 10.1016/S0960-894X(96)00563-X
CHEMBL105560 11867 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranesBinding affinity against NK1 receptor by displacement of [3H]SP from bovine retina membranes
ChEMBL 531 6 1 3 7.2 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccc(Cl)c(Cl)c2)c1 10.1016/S0960-894X(96)00563-X
11295303 101837 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 517 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CN)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
CHEMBL25521 101837 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandBinding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
ChEMBL 517 5 1 3 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(CN)nc2ccccc2c1-c1ccccc1 10.1021/jm034219a
44305557 209592 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards tachykinin receptor 1Binding affinity towards tachykinin receptor 1
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1021/jm058225d
CHEMBL62341 209592 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards tachykinin receptor 1Binding affinity towards tachykinin receptor 1
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1021/jm058225d
44287803 106986 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 456 5 1 4 5.0 COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
CHEMBL288371 106986 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.Compound was tested for its binding affinity to NK1 receptor in [3H]SP binding assay on human IM9 lymphoblasts cultured cell line.
ChEMBL 456 5 1 4 5.0 COc1ccccc1CC(=N)N1CC2C(=O)CSC(c3ccccc3)(c3ccccc3)C2C1 10.1016/0960-894X(95)00277-Z
44410194 83658 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 511 5 1 6 5.0 Cn1nnnc1C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
CHEMBL206983 83658 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cells
ChEMBL 511 5 1 6 5.0 Cn1nnnc1C1CC2(c3ccccc3)NC1CCC2OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.12.069
16755253 192968 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 528 4 0 4 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cnnc12 10.1016/j.bmc.2008.05.067
CHEMBL487276 192968 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsDisplacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cells
ChEMBL 528 4 0 4 6.9 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1c(-c2ccccc2)c2ccccc2n2cnnc12 10.1016/j.bmc.2008.05.067
118722858 122972 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 399 7 1 5 4.9 O=C(N[C@@H](Cc1ccccc1)c1nnc(-c2ccccc2)o1)OCc1ccccc1 10.1021/ml5002954
CHEMBL3358424 122972 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 399 7 1 5 4.9 O=C(N[C@@H](Cc1ccccc1)c1nnc(-c2ccccc2)o1)OCc1ccccc1 10.1021/ml5002954
44306757 107730 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 511 9 2 4 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)/C=C/c1ccccc1 10.1021/jm00039a022
CHEMBL294114 107730 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 511 9 2 4 3.0 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C1C[C@@H](O)CN1C(=O)/C=C/c1ccccc1 10.1021/jm00039a022
44306092 210203 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 525 11 4 4 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CC(N)=O)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
CHEMBL65703 210203 0 None - 0 Guinea pig 8.1 pIC50 = 8.1 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 525 11 4 4 2.5 CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(=O)C(CC(N)=O)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00039a022
44324793 213781 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 670 17 2 5 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL91438 213781 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 670 17 2 5 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCNCc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
44324775 214093 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 684 17 1 5 7.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
CHEMBL93401 214093 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 684 17 1 5 7.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)NCCN(C)Cc2ccccc2OC)C1 10.1016/S0960-894X(01)80747-2
44289197 107931 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 601 5 2 4 6.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1)c1cc(O)nc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL295425 107931 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 601 5 2 4 6.6 O=C(N[C@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2ccccc2)C1)c1cc(O)nc2ccccc12 10.1016/0960-894X(96)00287-9
104943 62160 39 None 1862 3 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL16192 62160 39 None 1862 3 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
19797460 127790 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.8 Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
CHEMBL356518 127790 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 451 6 0 2 6.8 Clc1cc(Cl)cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)c1 10.1021/jm00024a007
44305557 209592 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL62341 209592 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
inhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesinhibition of [3H]Sar-SP binding to Tachykinin receptor 1 of bovine retina membranes
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
10063954 105508 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
CHEMBL277918 105508 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 309 5 1 2 4.1 Cc1cc(C)cc(COCC2(c3ccccc3)CCNCC2)c1 10.1021/jm980376b
71541472 94180 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 436 6 0 3 5.5 CC1CC1c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
CHEMBL2333606 94180 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysisDisplacement of [125I] Substance P from human NK1 receptor expressed in human U373 cell membranes after 1 hr by scintillation counting analysis
ChEMBL 436 6 0 3 5.5 CC1CC1c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 10.1016/j.bmcl.2012.11.094
44346536 23077 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 10.1021/jm9700171
CHEMBL122580 23077 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.Binding affinity was measured against the Tachykinin receptor 1 in human IM-9 cells using [3H]SP as ligand.
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 10.1021/jm9700171
44306106 109584 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
CHEMBL305368 109584 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
In vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membraneIn vitro binding affinity against substance P receptor using [3H]SP as radioligand in guinea pig lung membrane
ChEMBL 556 8 2 5 3.3 CN(Cc1ccccc1)C(=O)[C@@H](Cc1cccc(F)c1)NC(=O)C1C[C@@H](O)CN1C(=O)c1cn(C)c2ccccc12 10.1021/jm00039a022
10531588 127133 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 597 13 3 6 3.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CC(=O)O 10.1021/jm950616c
CHEMBL353116 127133 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligandInhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
ChEMBL 597 13 3 6 3.5 COc1ccccc1CN(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(=O)CC(=O)O 10.1021/jm950616c
44346536 23077 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
CHEMBL122580 23077 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsInhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cells
ChEMBL 386 6 1 4 4.3 COc1ccc(CN[C@H]2C3CCN(CC3)[C@H]2c2cccc(Cl)c2)c(OC)c1 10.1016/S0960-894X(01)80859-3
19049319 169913 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
CHEMBL417784 169913 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(00)80063-3
19049319 169913 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL417784 169913 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
19797439 43660 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 8 0 4 5.5 COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 10.1021/jm00024a007
CHEMBL145077 43660 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 443 8 0 4 5.5 COc1cc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc(OC)c1 10.1021/jm00024a007
19049319 169913 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1021/jm0311487
CHEMBL417784 169913 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsInhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
ChEMBL 345 7 1 2 5.0 Cc1cc(C)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1021/jm0311487
56658036 73237 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c(OC)c1 10.1016/j.bmc.2011.07.014
CHEMBL1817885 73237 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c(OC)c1 10.1016/j.bmc.2011.07.014
CHEMBL1852128 73237 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 451 7 0 4 5.2 COc1ccc(CN2CCC(=O)C(C(c3ccc(F)cc3)c3ccc(F)cc3)C2)c(OC)c1 10.1016/j.bmc.2011.07.014
23653789 10359 24 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
9280 10359 24 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
CHEMBL447955 10359 24 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
DB12973 10359 24 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
23653789 10359 24 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
9280 10359 24 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
CHEMBL447955 10359 24 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
DB12973 10359 24 None - 2 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
10698085 26177 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.7 Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
CHEMBL129354 26177 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)Tachykinin receptor 1 antagonistic activity as ability to inhibit [125I]BH-SP binding in human IM-9 cells (lymphoblast cells)
ChEMBL 559 3 0 4 6.7 Cc1ccc(-c2c3n(c(=O)c4ncccc24)C[C@H](C)CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)cc1 10.1021/jm990220r
24888942 14718 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 569 5 0 3 7.0 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
CHEMBL1090437 14718 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serumDisplacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of 50% human serum
ChEMBL 569 5 0 3 7.0 C[C@@H](O[C@H]1CN2C(=O)C=C(C3=CCOCC3)CC2[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.01.120
44299463 203323 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 409 7 1 2 5.4 Cc1cc(Br)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL56372 203323 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 409 7 1 2 5.4 Cc1cc(Br)cc(COCC(N)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
44290080 201636 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 499 11 2 4 4.5 COc1ccc(CC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
CHEMBL539937 201636 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineIn vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line
ChEMBL 499 11 2 4 4.5 COc1ccc(CC(=O)NC(Cc2c[nH]c3ccccc23)CN(Cc2ccccc2OC)C(C)=O)cc1 10.1016/s0960-894x(01)00250-5
44319356 111148 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 607 10 1 6 4.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)c(F)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL310173 111148 0 None - 0 Guinea pig 8.0 pIC50 = 8.0 Binding
Binding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SPBinding affinity for NK1 receptor in guinea pig lung was determined by using [125 I]-Bolton Hunter labeled SP
ChEMBL 607 10 1 6 4.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)c(F)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44415529 146805 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 2 5.2 NC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
CHEMBL380017 146805 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]SP from human cloned NK1 receptor expressed in CHO cellsDisplacement of [125I]SP from human cloned NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 2 5.2 NC(=O)N[C@H]1CC[C@H](OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1c1ccccc1 10.1016/j.bmcl.2006.06.035
24993313 193810 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 532 4 1 2 6.8 CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
CHEMBL490869 193810 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminDisplacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin
ChEMBL 532 4 1 2 6.8 CNC(=O)N1C[C@H]2CC[C@H](O[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)[C@@H]2C1 10.1021/jm8016514
10499846 37997 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 341 7 1 4 3.5 COc1cc(COCC2(c3ccccc3)CCNCC2)cc(OC)c1 10.1021/jm980376b
CHEMBL140101 37997 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in CHO cells.
ChEMBL 341 7 1 4 3.5 COc1cc(COCC2(c3ccccc3)CCNCC2)cc(OC)c1 10.1021/jm980376b
130847 207359 18 None - 0 Guinea pig 7.1 pIC50 = 7.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
CHEMBL59915 207359 18 None - 0 Guinea pig 7.1 pIC50 = 7.1 Binding
Displacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal stripsDisplacement of specific binding of [3H]SP to tachykinin receptor 1 from the isolated guinea pig tracheal strips
ChEMBL 697 16 4 9 3.3 CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 10.1021/jm00089a011
43815 193699 64 None - 25 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1016/j.bmc.2013.02.010
CHEMBL1708 193699 64 None - 25 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1016/j.bmc.2013.02.010
CHEMBL490 193699 64 None - 25 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
ChEMBL 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 10.1016/j.bmc.2013.02.010
CHEMBL2112245 216011 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
54581252 67926 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 486 4 0 2 7.0 Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765496 67926 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 486 4 0 2 7.0 Cc1nc(Cl)cc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
11248796 168428 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 488 4 0 2 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
CHEMBL413027 168428 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 488 4 0 2 7.2 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1cnc2ccccc2c1-c1ccccc1 10.1016/j.bmc.2011.02.031
44289102 175288 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 495 8 1 5 5.3 COc1cc(OC)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL435367 175288 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retinaInhibition of [3H]-SP radioligand binding to NK1 receptor from bovine retina
ChEMBL 495 8 1 5 5.3 COc1cc(OC)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
76311027 112586 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 499 6 0 2 7.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
CHEMBL3126969 112586 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Antagonist activity at human NK1 receptorAntagonist activity at human NK1 receptor
ChEMBL 499 6 0 2 7.6 FC(F)(F)c1cc(COCC2(c3ccccc3)CCC(N3CCCCC3)CC2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2014.01.036
18986942 210694 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 371 5 1 2 5.1 Cc1cc(C)cc(COCC(N)C2c3ccccc3CCc3ccccc32)c1 10.1016/S0960-894X(00)80063-3
CHEMBL69051 210694 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsBinding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cells
ChEMBL 371 5 1 2 5.1 Cc1cc(C)cc(COCC(N)C2c3ccccc3CCc3ccccc32)c1 10.1016/S0960-894X(00)80063-3
44299898 169908 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 399 10 1 2 6.0 Cc1cc(C)cc(COCC(NCC2CC2)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
CHEMBL417766 169908 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PBinding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
ChEMBL 399 10 1 2 6.0 Cc1cc(C)cc(COCC(NCC2CC2)C(c2ccccc2)c2ccccc2)c1 10.1016/S0960-894X(01)80531-X
19797414 43953 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
CHEMBL145308 43953 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 401 6 0 2 5.6 Fc1ccccc1COC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1 10.1021/jm00024a007
44324681 119242 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 592 14 0 4 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)C)C1 10.1016/S0960-894X(01)80747-2
CHEMBL329840 119242 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsInhibition of [125I]-Substance P binding to human NK1 receptors in CHO cells
ChEMBL 592 14 0 4 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)N(C)CCN(C)C)C1 10.1016/S0960-894X(01)80747-2
44281769 116437 7 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(01)80821-0
CHEMBL32248 116437 7 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cellsInhibition of [125I]BH-SP binding to tachykinin NK1 receptor in human IM-9 cells
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(01)80821-0
44345938 18775 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 350 7 4 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1016/S0960-894X(96)00570-7
CHEMBL118328 18775 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cellsTested for binding affinity against [125I]BH-SP binding to neurokinin-1 (NK-1) receptor in human IM-9 cells
ChEMBL 350 7 4 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1016/S0960-894X(96)00570-7
10339539 116545 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.3 CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL323128 116545 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 377 5 1 2 5.3 CC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccccc1 10.1016/0960-894X(95)00476-A
CHEMBL2092730 215980 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of Tachykinin receptor 1Inhibition of Tachykinin receptor 1
ChEMBL None None None C[C@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O 10.1021/jm960281e
45271306 202451 0 None -645 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL556537 202451 0 None -645 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
46227362 209363 0 None -301 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL611926 209363 0 None -301 4 Rat 7.0 pIC50 = 7.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44274254 86981 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cccc(Cl)c23)CC1 10.1016/s0960-894x(01)00182-2
CHEMBL21366 86981 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsConcentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells
ChEMBL 507 6 1 3 6.4 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)[nH]c3cccc(Cl)c23)CC1 10.1016/s0960-894x(01)00182-2
11661466 43690 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL145103 43690 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1Inhibition of binding of [125I]SP to the CHO cell line expressing human Tachykinin receptor 1
ChEMBL 408 6 0 3 5.4 N#Cc1ccc(COC2C3CCN(CC3)C2C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00024a007
CHEMBL2112246 216012 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H197A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44274444 89353 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 597 8 0 4 8.0 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(Cc3ccccc3)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
CHEMBL21787 89353 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cells(*).
ChEMBL 597 8 0 4 8.0 COc1ccccc1N1CCN(C(=O)CCc2c(-c3ccc(Cl)cc3)n(Cc3ccccc3)c3ccc(Cl)cc23)CC1 10.1016/s0960-894x(01)00183-4
11801586 12238 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 591 9 3 4 5.2 CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL107502 12238 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 591 9 3 4 5.2 CC(=O)Nc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL2112245 216011 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.Tested for binding affinity against H265A mutant NK1 receptor using [125]SP radioligand in COS cells.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
CHEMBL2369766 216462 0 None - 0 Guinea pig 7.0 pIC50 = 7.0 Binding
Concentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortexConcentration producing half-maximal inhibition of specific binding of. [125I]Bolton-Hunter Substance P to NK-1 receptors in the guinea pig cerebral cortex
ChEMBL None None None CCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/0960-894X(94)85022-4
56671764 73216 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 423 5 0 2 6.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817821 73216 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 423 5 0 2 6.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852008 73216 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 423 5 0 2 6.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1016/j.bmc.2011.07.014
56671762 73234 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 391 5 0 2 5.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1817820 73234 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 391 5 0 2 5.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
CHEMBL1852121 73234 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 391 5 0 2 5.2 O=C1CCN(Cc2ccccc2)CC1C(c1ccc(F)cc1)c1ccc(F)cc1 10.1016/j.bmc.2011.07.014
23025476 73249 13 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 355 5 0 2 4.9 O=C1CCN(Cc2ccccc2)CC1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2011.07.014
CHEMBL1817817 73249 13 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 355 5 0 2 4.9 O=C1CCN(Cc2ccccc2)CC1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2011.07.014
CHEMBL1852184 73249 13 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from human tachykinin NK1 receptor expressed in IM9 cells after 30 mins by scintillation counting
ChEMBL 355 5 0 2 4.9 O=C1CCN(Cc2ccccc2)CC1C(c1ccccc1)c1ccccc1 10.1016/j.bmc.2011.07.014
2090 9543 25 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
5311312 9543 25 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
CHEMBL437797 9543 25 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.Inhibitory activity against binding of [125I]Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.
ChEMBL None None None None 10.1016/0960-894X(95)00582-E
44358847 36943 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 515 10 3 5 5.3 COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1OC 10.1021/jm00022a010
CHEMBL139017 36943 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards tachykinin receptor 1 in human IM9 cells.Binding affinity towards tachykinin receptor 1 in human IM9 cells.
ChEMBL 515 10 3 5 5.3 COc1ccc(COC(=O)N[C@](C)(Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)c2ccccc2)cc1OC 10.1021/jm00022a010
54586136 67922 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 452 4 0 2 6.4 Cc1nccc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
CHEMBL1765492 67922 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 minsDisplacement of [125I]BH-SP from human recombinant NK1 receptor expressed in CHO cells after 90 mins
ChEMBL 452 4 0 2 6.4 Cc1nccc(-c2ccccc2)c1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.02.031
2090 9543 25 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL None None None None 10.1021/jm950892r
5311312 9543 25 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL None None None None 10.1021/jm950892r
CHEMBL437797 9543 25 None -309 4 Human 7.0 pIC50 = 7.0 Binding
Inhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance PInhibitory activity against Tachykinin receptor 1 in human lymphoma IM9 cells labeled with [125 I] Bolton-Hunter substance P
ChEMBL None None None None 10.1021/jm950892r
44375315 63281 0 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL163510 63281 0 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
In vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assayIn vitro binding affinity against Tachykinin receptor 1 in guinea pig ileum using organ bath assay
ChEMBL 628 12 4 8 4.2 CSCCNS(=O)(=O)c1ccc(N/N=C(\S)N2CCC[C@H]2C(=O)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
44318671 112900 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 327 2 1 3 3.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2)C3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL313432 112900 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cellsDisplacement of [125I]-labeled substance P from human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 327 2 1 3 3.4 Fc1ccc([C@@H]2NCCOC23COC[C@H](c2ccccc2)C3)cc1 10.1016/s0960-894x(02)00506-1
15037918 51628 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 400 6 1 2 5.2 Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
CHEMBL152239 51628 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandBinding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand
ChEMBL 400 6 1 2 5.2 Fc1ccccc1CN[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81197-5
5757 10758 12 None - 1 Human 10.5 pKd = 10.5 Binding
Binding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constantBinding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constant
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
9832383 10758 12 None - 1 Human 10.5 pKd = 10.5 Binding
Binding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constantBinding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constant
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
CHEMBL522987 10758 12 None - 1 Human 10.5 pKd = 10.5 Binding
Binding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constantBinding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constant
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
DB11949 10758 12 None - 1 Human 10.5 pKd = 10.5 Binding
Binding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constantBinding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constant
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
10907397 50658 0 None - 1 Human 10.1 pKd = 10.1 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 1 4 4.6 O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151177 50658 0 None - 1 Human 10.1 pKd = 10.1 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 1 4 4.6 O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
44366788 50929 0 None - 1 Human 9.9 pKd = 9.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 493 6 0 4 4.6 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1CCCCC1 10.1021/jm0209331
CHEMBL151585 50929 0 None - 1 Human 9.9 pKd = 9.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 493 6 0 4 4.6 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1CCCCC1 10.1021/jm0209331
22901331 18753 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 18753 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 18753 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 18753 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 18753 0 None - 1 Rat 9.7 pKd = 9.7 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
18964186 211083 0 None 3 3 Human 9.5 pKd = 9.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1021/jm0209331
CHEMBL71397 211083 0 None 3 3 Human 9.5 pKd = 9.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1021/jm0209331
2102 7972 21 None 2 2 Guinea pig 9.5 pKd = 9.5 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
5311057 7972 21 None 2 2 Guinea pig 9.5 pKd = 9.5 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
CHEMBL441225 7972 21 None 2 2 Guinea pig 9.5 pKd = 9.5 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
21836542 49076 0 None - 1 Human 9.4 pKd = 9.4 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 8 1 4 4.1 O=C(O)C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL149794 49076 0 None - 1 Human 9.4 pKd = 9.4 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 8 1 4 4.1 O=C(O)C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11005795 48960 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1ccccc1CN1CC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CCC1=O 10.1021/jm0209331
CHEMBL149690 48960 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1ccccc1CN1CC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CCC1=O 10.1021/jm0209331
21699577 50122 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 536 7 1 3 6.4 O=C1CCC(CCN2CCC(O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150709 50122 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 536 7 1 3 6.4 O=C1CCC(CCN2CCC(O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
10918128 126629 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 501 7 0 4 4.5 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL348653 126629 0 None - 1 Human 9.3 pKd = 9.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 501 7 0 4 4.5 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
10973497 50011 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 533 7 0 4 4.2 O=C1CCC(CCN2CC(N3CC[S+]([O-])CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150619 50011 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 533 7 0 4 4.2 O=C1CCC(CCN2CC(N3CC[S+]([O-])CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
23224631 50691 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 541 7 1 4 5.1 O=C1CCC(CCN2CC(N3C4CCC3CC(O)C4)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151231 50691 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 541 7 1 4 5.1 O=C1CCC(CCN2CC(N3C4CCC3CC(O)C4)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
11071954 172117 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 578 8 0 5 3.7 CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
CHEMBL423584 172117 0 None - 1 Human 9.2 pKd = 9.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 578 8 0 5 3.7 CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
22901331 18753 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 18753 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 18753 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 18753 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 18753 0 None - 1 Rat 9.0 pKd = 9.0 Binding
Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
10864234 50757 0 None - 1 Human 9.0 pKd = 9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 517 7 0 4 5.2 O=C1CCC(CCN2CC(N3CCSCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151317 50757 0 None - 1 Human 9.0 pKd = 9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 517 7 0 4 5.2 O=C1CCC(CCN2CC(N3CCSCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
10929285 73483 0 None 1 2 Human 9.0 pKd = 9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
CHEMBL185572 73483 0 None 1 2 Human 9.0 pKd = 9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
21836537 48138 10 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL148998 48138 10 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
44366712 50277 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 477 7 0 4 4.0 O=C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL150842 50277 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 477 7 0 4 4.0 O=C1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11028028 50445 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 549 7 0 5 3.9 O=C1CCC(CCN2CC(N3CCS(=O)(=O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150997 50445 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 549 7 0 5 3.9 O=C1CCC(CCN2CC(N3CCS(=O)(=O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
11060266 50919 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
CHEMBL151570 50919 0 None - 1 Human 8.9 pKd = 8.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
22901331 18753 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 18753 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 18753 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 18753 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 18753 0 None - 1 Rat 8.8 pKd = 8.8 Binding
Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
10984417 50554 0 None - 1 Human 8.8 pKd = 8.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 542 7 0 4 4.3 CC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
CHEMBL151088 50554 0 None - 1 Human 8.8 pKd = 8.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 542 7 0 4 4.3 CC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
44366743 50739 0 None - 1 Human 8.8 pKd = 8.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 479 7 1 4 3.8 O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
CHEMBL151289 50739 0 None - 1 Human 8.8 pKd = 8.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 479 7 1 4 3.8 O=C1CCC(CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
11813113 49910 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 501 7 1 4 4.2 O=C1CCC(CCN2CC(N3CCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150537 49910 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 501 7 1 4 4.2 O=C1CCC(CCN2CC(N3CCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
11827396 49981 1 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 1 4 4.6 O=C1CCC(CCN2CC(N3CCCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL150585 49981 1 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 1 4 4.6 O=C1CCC(CCN2CC(N3CCCC(O)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
21836550 126261 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL345309 126261 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11071343 128295 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.9 O=C1CCC(CCN2CC(N3CCCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL358418 128295 0 None - 1 Human 8.7 pKd = 8.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.9 O=C1CCC(CCN2CC(N3CCCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
44366283 46314 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL147301 46314 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11103819 126257 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 577 8 0 4 6.2 O=C1CCC(CCN2CC(N3CCOC(c4ccccc4)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL345288 126257 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 577 8 0 4 6.2 O=C1CCC(CCN2CC(N3CCOC(c4ccccc4)C3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
21836558 128063 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 556 9 1 5 3.4 CS(=O)(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL357946 128063 0 None - 1 Human 8.0 pKd = 8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 556 9 1 5 3.4 CS(=O)(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11123982 50959 0 None - 1 Human 7.0 pKd = 7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 502 7 0 5 3.9 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccncc1 10.1021/jm0209331
CHEMBL151621 50959 0 None - 1 Human 7.0 pKd = 7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 502 7 0 5 3.9 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccncc1 10.1021/jm0209331
44300138 107674 0 None - 1 Human 6.0 pKd = 6.0 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 567 9 6 3 5.6 N=C(N)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL293804 107674 0 None - 1 Human 6.0 pKd = 6.0 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 567 9 6 3 5.6 N=C(N)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
21836503 48726 0 None - 1 Human 7.9 pKd = 7.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 464 7 1 4 3.2 O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
CHEMBL149469 48726 0 None - 1 Human 7.9 pKd = 7.9 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 464 7 1 4 3.2 O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
44300056 107613 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 630 17 3 2 9.9 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL293374 107613 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 630 17 3 2 9.9 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL555235 107613 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 630 17 3 2 9.9 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
44300032 205873 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 525 8 4 3 6.0 NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL58873 205873 0 None - 1 Human 5.9 pKd = 5.9 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 525 8 4 3 6.0 NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
52937467 69297 0 None -9 3 Human 7.8 pKd = 7.8 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL1782141 69297 0 None -9 3 Human 7.8 pKd = 7.8 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
21836538 46261 0 None - 1 Human 7.8 pKd = 7.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 520 8 1 4 3.9 CC(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL147241 46261 0 None - 1 Human 7.8 pKd = 7.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 520 8 1 4 3.9 CC(=O)NC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
10864203 50472 0 None - 1 Human 7.8 pKd = 7.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 514 7 0 4 4.4 CN1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
CHEMBL151026 50472 0 None - 1 Human 7.8 pKd = 7.8 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 514 7 0 4 4.4 CN1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)C2)CC1 10.1021/jm0209331
44300037 198711 0 None - 1 Human 5.8 pKd = 5.8 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 681 14 7 5 4.6 NC(N)=NCCC[C@H](N)C(=O)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL52004 198711 0 None - 1 Human 5.8 pKd = 5.8 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 681 14 7 5 4.6 NC(N)=NCCC[C@H](N)C(=O)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
104943 62160 39 None 1862 3 Human 7.8 pKd = 7.8 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
CHEMBL16192 62160 39 None 1862 3 Human 7.8 pKd = 7.8 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
71452185 90310 0 None -2 2 Human 7.8 pKd = 7.8 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203707 90310 0 None -2 2 Human 7.8 pKd = 7.8 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44300106 205058 0 None - 1 Human 5.8 pKd = 5.8 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 623 11 5 3 6.7 CC/N=C(\NCC)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL57584 205058 0 None - 1 Human 5.8 pKd = 5.8 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 623 11 5 3 6.7 CC/N=C(\NCC)NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
11135103 128352 0 None - 1 Human 7.7 pKd = 7.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 519 7 0 4 4.6 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccc(F)cc1 10.1021/jm0209331
CHEMBL358600 128352 0 None - 1 Human 7.7 pKd = 7.7 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 519 7 0 4 4.6 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccc(F)cc1 10.1021/jm0209331
11113999 50641 0 None - 1 Human 8.6 pKd = 8.6 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.0 O=C1CCC(CCN2CC(N3CCOCC3=O)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151155 50641 0 None - 1 Human 8.6 pKd = 8.6 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.0 O=C1CCC(CCN2CC(N3CCOCC3=O)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
11763019 126468 0 None - 1 Human 8.6 pKd = 8.6 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1cccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)c1 10.1021/jm0209331
CHEMBL347284 126468 0 None - 1 Human 8.6 pKd = 8.6 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1cccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)c1 10.1021/jm0209331
44241710 90306 1 None 3 2 Human 7.5 pKd = 7.5 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203703 90306 1 None 3 2 Human 7.5 pKd = 7.5 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44300497 107535 0 None - 1 Human 6.5 pKd = 6.5 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 695 18 3 2 10.3 CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL292816 107535 0 None - 1 Human 6.5 pKd = 6.5 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 695 18 3 2 10.3 CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
22901331 18753 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 18753 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 18753 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 18753 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 18753 0 None - 1 Rat 8.5 pKd = 8.5 Binding
Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
11071001 49745 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 489 9 1 4 4.1 CN(CCO)C1CN(CCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)C1 10.1021/jm0209331
CHEMBL150381 49745 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 489 9 1 4 4.1 CN(CCO)C1CN(CCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)C1 10.1021/jm0209331
44366988 50781 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 596 9 1 4 5.5 CC(=O)NC1(c2ccccc2)CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL151356 50781 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 596 9 1 4 5.5 CC(=O)NC1(c2ccccc2)CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
44366559 126309 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 557 9 1 5 2.4 CNS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL345733 126309 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 557 9 1 5 2.4 CNS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
44366577 127889 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL357357 127889 0 None - 1 Human 8.5 pKd = 8.5 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
52937271 69295 0 None - 1 Human 8.4 pKd = 8.4 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL1782139 69295 0 None - 1 Human 8.4 pKd = 8.4 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
118730933 124935 0 None -389 2 Human 6.4 pKd = 6.4 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408519 124935 0 None -389 2 Human 6.4 pKd = 6.4 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
6604943 108517 1 None - 1 Human 6.4 pKd = 6.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 712 18 3 2 11.5 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N/C(=N\C2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL299701 108517 1 None - 1 Human 6.4 pKd = 6.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 712 18 3 2 11.5 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N/C(=N\C2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL555236 108517 1 None - 1 Human 6.4 pKd = 6.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 712 18 3 2 11.5 CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N/C(=N\C2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
44300034 205284 0 None - 1 Human 5.4 pKd = 5.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 569 9 5 4 5.7 NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)c(C(=O)O)c1 10.1016/S0960-894X(97)00328-4
CHEMBL57778 205284 0 None - 1 Human 5.4 pKd = 5.4 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 569 9 5 4 5.7 NCc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)c(C(=O)O)c1 10.1016/S0960-894X(97)00328-4
71457524 90308 0 None -5 2 Human 7.4 pKd = 7.4 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203705 90308 0 None -5 2 Human 7.4 pKd = 7.4 Binding
Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsPartial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10864032 50475 0 None - 1 Human 8.3 pKd = 8.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 500 7 1 4 4.0 O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
CHEMBL151028 50475 0 None - 1 Human 8.3 pKd = 8.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 500 7 1 4 4.0 O=C1CCC(CCN2CC(N3CCNCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1021/jm0209331
21836496 127670 0 None - 1 Human 8.3 pKd = 8.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 1 4 3.0 NC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL355973 127670 0 None - 1 Human 8.3 pKd = 8.3 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 1 4 3.0 NC(=O)N1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
104943 62160 39 None 1862 3 Human 8.3 pKd = 8.3 Binding
Competitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
CHEMBL16192 62160 39 None 1862 3 Human 8.3 pKd = 8.3 Binding
Competitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
118730934 124936 0 None -363 2 Human 6.3 pKd = 6.3 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 835 15 6 7 4.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408520 124936 0 None -363 2 Human 6.3 pKd = 6.3 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 835 15 6 7 4.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
44300055 107782 0 None - 1 Human 6.3 pKd = 6.3 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 695 18 3 2 10.3 CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL294452 107782 0 None - 1 Human 6.3 pKd = 6.3 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 695 18 3 2 10.3 CCCC[N+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
11813288 50048 0 None - 1 Human 8.2 pKd = 8.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1ccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)cc1 10.1021/jm0209331
CHEMBL150644 50048 0 None - 1 Human 8.2 pKd = 8.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 515 7 0 4 4.8 Cc1ccc(CN2CC(CCN3CC(N4CCOCC4)C3)(c3ccc(Cl)c(Cl)c3)CCC2=O)cc1 10.1021/jm0209331
44366742 50738 0 None - 1 Human 8.2 pKd = 8.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
CHEMBL151288 50738 0 None - 1 Human 8.2 pKd = 8.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1021/jm0209331
11103197 85188 0 None - 1 Human 6.2 pKd = 6.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CC[C@@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
CHEMBL2111193 85188 0 None - 1 Human 6.2 pKd = 6.2 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 507 7 0 4 4.8 O=C1CC[C@@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1021/jm0209331
132927 10856 4 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
138398059 10856 4 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
677 10856 4 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
CHEMBL294453 10856 4 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
CHEMBL551291 10856 4 None -6 2 Human 6.2 pKd = 6.2 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 746 18 3 2 8.5 CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] 10.1016/S0960-894X(97)00328-4
9847362 128467 0 None - 1 Human 8.1 pKd = 8.1 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 465 7 0 4 3.7 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
CHEMBL358694 128467 0 None - 1 Human 8.1 pKd = 8.1 Binding
Functional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assayFunctional potency against Tachykinin receptor 2 (NK2) in rabbit pulmonary artery assay
ChEMBL 465 7 0 4 3.7 O=C1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1021/jm0209331
135413536 7236 85 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
230 7236 85 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
3490 7236 85 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
6918365 7236 85 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
CHEMBL1471 7236 85 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
DB00673 7236 85 None 50 2 Human 8.1 pKd = 8.1 Binding
Competitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 minsCompetitive inhibition of human NK1 F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
44300139 205822 0 None - 1 Human 6.1 pKd = 6.1 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 567 9 6 3 5.6 N=C(N)NCc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
CHEMBL58598 205822 0 None - 1 Human 6.1 pKd = 6.1 Binding
Binding affinity towards Tachykinin receptor 1, activity expressed as KdBinding affinity towards Tachykinin receptor 1, activity expressed as Kd
ChEMBL 567 9 6 3 5.6 N=C(N)NCc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N=C(NC2CCCCC2)NC2CCCCC2)cc1 10.1016/S0960-894X(97)00328-4
118730932 124934 0 None -2951 2 Human 6.0 pKd = 6.0 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 834 15 7 7 3.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408518 124934 0 None -2951 2 Human 6.0 pKd = 6.0 Binding
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptideAntagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
ChEMBL 834 15 7 7 3.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
10288987 24986 0 None - 1 Human 11.0 pKi = 11 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 nan
CHEMBL1270066 24986 0 None - 1 Human 11.0 pKi = 11 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 nan
122187724 129844 0 None 17 4 Human 10.8 pKi = 10.8 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 692 11 5 6 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3609620 129844 0 None 17 4 Human 10.8 pKi = 10.8 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 692 11 5 6 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10216430 86680 0 None 204173 2 Human 10.7 pKi = 10.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 C[C@@H](OCC1(c2ccccc2)CC(N)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL212428 86680 0 None 204173 2 Human 10.7 pKi = 10.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 C[C@@H](OCC1(c2ccccc2)CC(N)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
5752 10777 24 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/j.bmc.2011.08.070
6918331 10777 24 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/j.bmc.2011.08.070
CHEMBL522302 10777 24 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/j.bmc.2011.08.070
DB12436 10777 24 None - 1 Human 10.6 pKi = 10.6 Binding
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation countingDisplacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/j.bmc.2011.08.070
5752 10777 24 None - 1 Human 10.6 pKi = 10.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/0960-894X(96)00163-1
6918331 10777 24 None - 1 Human 10.6 pKi = 10.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/0960-894X(96)00163-1
CHEMBL522302 10777 24 None - 1 Human 10.6 pKi = 10.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/0960-894X(96)00163-1
DB12436 10777 24 None - 1 Human 10.6 pKi = 10.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1016/0960-894X(96)00163-1
CHEMBL3609617 218610 0 None 501 4 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10714695 48810 0 None - 1 Human 10.5 pKi = 10.5 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 4 5.0 COc1ccc(-c2ccsc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL149557 48810 0 None - 1 Human 10.5 pKi = 10.5 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 4 5.0 COc1ccc(-c2ccsc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
9852175 84991 15 None 1 3 Mongolian jird 10.5 pKi = 10.5 Binding
Displacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2105667 84991 15 None 1 3 Mongolian jird 10.5 pKi = 10.5 Binding
Displacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
DB12427 84991 15 None 1 3 Mongolian jird 10.5 pKi = 10.5 Binding
Displacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2419537 217217 0 None 32 4 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
44264764 19959 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 406 8 2 7 3.2 CCCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL1191008 19959 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 406 8 2 7 3.2 CCCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL542044 19959 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 406 8 2 7 3.2 CCCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
22880695 20358 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 410 7 2 8 3.0 COc1ccc(-n2nnnc2SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1194085 20358 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 410 7 2 8 3.0 COc1ccc(-n2nnnc2SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL545594 20358 0 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 410 7 2 8 3.0 COc1ccc(-n2nnnc2SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
127944 127703 3 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL356062 127703 3 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL555572 127703 3 None - 1 Human 10.4 pKi = 10.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL3608939 218607 0 None 1 3 Rat 10.4 pKi = 10.4 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL261390 217297 0 None 34 3 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
44177770 129780 0 None 31 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 939 20 8 9 4.1 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3608937 129780 0 None 31 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 939 20 8 9 4.1 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10500669 45850 0 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 391 6 2 5 4.6 COc1ccc(-c2c(C)noc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL146885 45850 0 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 391 6 2 5 4.6 COc1ccc(-c2c(C)noc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10809458 126165 0 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 5 2 3 4.0 COc1ccc(Br)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL344536 126165 0 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 5 2 3 4.0 COc1ccc(Br)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
127944 127703 3 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL356062 127703 3 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL555572 127703 3 None - 1 Human 10.3 pKi = 10.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2cnnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
5752 10777 24 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm900023b
6918331 10777 24 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm900023b
CHEMBL522302 10777 24 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm900023b
DB12436 10777 24 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 10.1021/jm900023b
44264847 19594 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 378 6 2 7 2.6 COc1ccc(-n2nnnc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1188354 19594 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 378 6 2 7 2.6 COc1ccc(-n2nnnc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL536103 19594 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 378 6 2 7 2.6 COc1ccc(-n2nnnc2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
44264766 20327 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 392 7 2 7 2.8 CCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL1193883 20327 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 392 7 2 7 2.8 CCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL545360 20327 0 None - 1 Human 10.3 pKi = 10.3 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 392 7 2 7 2.8 CCc1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
45271306 202451 0 None 14 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL556537 202451 0 None 14 4 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
11793012 127825 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 362 6 2 4 4.5 COc1ccc(-c2ccoc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL356786 127825 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 362 6 2 4 4.5 COc1ccc(-c2ccoc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10499614 128756 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 373 6 2 4 4.3 COc1ccc(-c2ccncc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL359188 128756 0 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 373 6 2 4 4.3 COc1ccc(-c2ccncc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
9852175 84991 15 None -1 3 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2105667 84991 15 None -1 3 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
DB12427 84991 15 None -1 3 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
22880684 20267 0 None - 1 Human 10.2 pKi = 10.2 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 442 7 2 9 1.7 COc1ccc(-n2nnnc2S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1193478 20267 0 None - 1 Human 10.2 pKi = 10.2 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 442 7 2 9 1.7 COc1ccc(-n2nnnc2S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL544891 20267 0 None - 1 Human 10.2 pKi = 10.2 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 442 7 2 9 1.7 COc1ccc(-n2nnnc2S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
24969015 99752 7 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2441373 99752 7 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2419538 217218 0 None 75 4 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC1(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCC1 10.1016/j.bmcl.2013.06.065
44177570 68034 0 None 15 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766204 68034 0 None 15 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
44233185 201601 0 None 47 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL539193 201601 0 None 47 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
135413536 7236 85 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
230 7236 85 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
3490 7236 85 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
6918365 7236 85 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
CHEMBL1471 7236 85 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
DB00673 7236 85 None 50 2 Human 10.1 pKi = 10.1 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2013.12.033
10641076 175196 0 None - 1 Human 10.1 pKi = 10.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 342 6 2 4 4.0 COc1ccc(SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL434884 175196 0 None - 1 Human 10.1 pKi = 10.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 342 6 2 4 4.0 COc1ccc(SC)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10152974 64642 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 519 4 0 2 6.5 Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672044 64642 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 519 4 0 2 6.5 Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
15463537 20769 0 None - 1 Human 10.1 pKi = 10.1 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 404 7 2 7 3.1 COc1ccc(-n2nnnc2C2CC2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1197007 20769 0 None - 1 Human 10.1 pKi = 10.1 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 404 7 2 7 3.1 COc1ccc(-n2nnnc2C2CC2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL558990 20769 0 None - 1 Human 10.1 pKi = 10.1 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 404 7 2 7 3.1 COc1ccc(-n2nnnc2C2CC2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
51002938 64645 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 531 4 0 2 6.6 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672047 64645 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 531 4 0 2 6.6 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL389652 219209 0 None 2 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL389652 219209 0 None 2 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL2419542 217222 0 None 6 3 Rat 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL2419541 217221 0 None 3 4 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL2419543 217223 0 None 16 4 Human 10.0 pKi = 10.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
9871118 152910 0 None - 1 Human 10.0 pKi = 10 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 514 6 2 5 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](n2cn[nH]c2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3919618 152910 0 None - 1 Human 10.0 pKi = 10 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 514 6 2 5 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](n2cn[nH]c2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
2109 10909 4 None 5 3 Human 10.0 pKi = 10 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
9852253 10909 4 None 5 3 Human 10.0 pKi = 10 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
CHEMBL129683 10909 4 None 5 3 Human 10.0 pKi = 10 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
10173872 146051 0 None 6309 2 Human 10.0 pKi = 10 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 459 6 1 2 6.0 CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
CHEMBL379072 146051 0 None 6309 2 Human 10.0 pKi = 10 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 459 6 1 2 6.0 CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
46227362 209363 0 None 12 4 Human 10.0 pKi = 10 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL611926 209363 0 None 12 4 Human 10.0 pKi = 10 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
51002993 64651 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 602 4 0 3 6.1 CC(=O)N1CCN([C@H]2CCN(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1021/jm1013264
CHEMBL1672053 64651 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 602 4 0 3 6.1 CC(=O)N1CCN([C@H]2CCN(C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1021/jm1013264
CHEMBL3609616 218609 0 None 1 4 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL2419539 217219 0 None 25 4 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
2109 10909 4 None 5 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
9852253 10909 4 None 5 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
CHEMBL129683 10909 4 None 5 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
10546738 172387 0 None - 1 Human 9.9 pKi = 9.9 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2ncnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL424301 172387 0 None - 1 Human 9.9 pKi = 9.9 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 364 6 2 7 2.3 COc1ccc(-n2ncnn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
23725089 7591 13 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
4401 7591 13 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
5758 7591 13 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
9917021 7591 13 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
CHEMBL1672054 7591 13 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
DB06634 7591 13 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
72203985 99750 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2441371 99750 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL1651026 215605 24 None - 1 Human 9.9 pKi = 9.9 Binding
Binding affinity to human NK1 receptor by radioligand displacement assayBinding affinity to human NK1 receptor by radioligand displacement assay
ChEMBL None None None CC(C)C[C@H](NC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1016/j.ejmech.2013.01.044
9961315 124702 0 None 2 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1ccc(C2CCN(CC[C@H](CN(C)C(=O)c3cc(C#N)cc4ccccc34)c3ccc(Cl)c(Cl)c3)CC2)c([S@+](C)[O-])c1 10.1021/jm020094i
CHEMBL340326 124702 0 None 2 3 Human 9.9 pKi = 9.9 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1ccc(C2CCN(CC[C@H](CN(C)C(=O)c3cc(C#N)cc4ccccc34)c3ccc(Cl)c(Cl)c3)CC2)c([S@+](C)[O-])c1 10.1021/jm020094i
51003118 64649 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 4 0 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672051 64649 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 4 0 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL3609616 218609 0 None -1 4 Rat 9.8 pKi = 9.8 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10288987 24986 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270066 24986 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
10495476 46685 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 314 5 2 3 3.4 COc1ccc(F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL147776 46685 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 314 5 2 3 3.4 COc1ccc(F)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10643148 128322 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 6 2 5 3.7 COc1ccc(-c2cncnc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL358575 128322 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 6 2 5 3.7 COc1ccc(-c2cncnc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10784942 128768 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 363 6 2 6 2.9 COc1ccc(-n2cncn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL359255 128768 0 None - 1 Human 9.8 pKi = 9.8 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 363 6 2 6 2.9 COc1ccc(-n2cncn2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
51002996 64655 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 5 1 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672058 64655 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 5 1 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
2102 7972 21 None 2 2 Guinea pig 9.8 pKi = 9.8 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
5311057 7972 21 None 2 2 Guinea pig 9.8 pKi = 9.8 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
CHEMBL441225 7972 21 None 2 2 Guinea pig 9.8 pKi = 9.8 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
105083 32223 3 None - 1 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SPIn vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SP
ChEMBL 296 5 2 3 3.3 COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 10.1021/jm00051a001
CHEMBL135022 32223 3 None - 1 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SPIn vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SP
ChEMBL 296 5 2 3 3.3 COc1ccccc1CNC1CCCN[C@H]1c1ccccc1 10.1021/jm00051a001
2102 7972 21 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
5311057 7972 21 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
CHEMBL441225 7972 21 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
2102 7972 21 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro inhibitory activity against human NK1 receptor was determinedIn vitro inhibitory activity against human NK1 receptor was determined
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
5311057 7972 21 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro inhibitory activity against human NK1 receptor was determinedIn vitro inhibitory activity against human NK1 receptor was determined
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
CHEMBL441225 7972 21 None -2 2 Human 9.8 pKi = 9.8 Binding
In vitro inhibitory activity against human NK1 receptor was determinedIn vitro inhibitory activity against human NK1 receptor was determined
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
9809876 26172 1 None 398 3 Human 9.8 pKi = 9.8 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
CHEMBL129321 26172 1 None 398 3 Human 9.8 pKi = 9.8 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
51003056 64646 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672048 64646 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
49863732 22103 0 None 24 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214025 22103 0 None 24 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
10217362 25066 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270565 25066 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
10547681 127856 0 None - 1 Human 9.7 pKi = 9.7 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 7 2.5 COc1ccc(-c2nnnn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL357029 127856 0 None - 1 Human 9.7 pKi = 9.7 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 7 2.5 COc1ccc(-c2nnnn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
21041073 145627 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL378156 145627 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
51003119 64650 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 4 0 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672052 64650 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 559 4 0 2 7.6 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
53320128 64653 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 505 4 1 2 6.1 CN[C@H]1CCN(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1021/jm1013264
CHEMBL1672056 64653 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 505 4 1 2 6.1 CN[C@H]1CCN(C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1021/jm1013264
10290124 99751 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2441372 99751 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysisDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 40 mins by scintillation counting analysis
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
10289148 153890 0 None - 1 Human 9.7 pKi = 9.7 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 502 5 2 4 5.6 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@]2(CN1)COC(=O)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3927453 153890 0 None - 1 Human 9.7 pKi = 9.7 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 502 5 2 4 5.6 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@]2(CN1)COC(=O)N2)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3609618 218611 0 None 16 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
44560810 180054 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 5.6 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL452534 180054 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 5.6 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
9958115 180278 0 None 6309 2 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL453054 180278 0 None 6309 2 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44560811 195772 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 5.6 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL508661 195772 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 5.6 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
11327981 189057 14 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 434 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@](C)(C(F)(F)F)OCC2 10.1016/j.bmc.2008.06.047
CHEMBL478392 189057 14 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsDisplacement of [3H]spiperone from NK1 receptor in human IM9 cells
ChEMBL 434 5 2 4 4.6 COc1cc2c(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)[C@](C)(C(F)(F)F)OCC2 10.1016/j.bmc.2008.06.047
CHEMBL229280 216237 0 None 23 3 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC[S+](C)[O-])NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
51003053 64656 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 563 7 1 3 6.7 COCCN[C@H]1CCN(C(=O)N(C)[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1021/jm1013264
CHEMBL1672059 64656 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 563 7 1 3 6.7 COCCN[C@H]1CCN(C(=O)N(C)[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](c2ccc(F)cc2C)C1 10.1021/jm1013264
44177669 68035 0 None 2 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766205 68035 0 None 2 4 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
10217361 25065 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270564 25065 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
5757 10758 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm1013264
9832383 10758 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm1013264
CHEMBL522987 10758 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm1013264
DB11949 10758 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm1013264
5757 10758 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
9832383 10758 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
CHEMBL522987 10758 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
DB11949 10758 12 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1021/jm900023b
10289302 25006 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(=O)C2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270175 25006 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(=O)C2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
9872808 64643 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 533 4 0 2 7.1 Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672045 64643 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 533 4 0 2 7.1 Cc1cc(F)ccc1[C@H]1C[C@@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
46227363 206444 0 None 28 4 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL592969 206444 0 None 28 4 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
2102 7972 21 None -2 2 Human 9.6 pKi = 9.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
5311057 7972 21 None -2 2 Human 9.6 pKi = 9.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL441225 7972 21 None -2 2 Human 9.6 pKi = 9.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
5757 10758 12 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmcl.2009.11.078
9832383 10758 12 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmcl.2009.11.078
CHEMBL522987 10758 12 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmcl.2009.11.078
DB11949 10758 12 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 10.1016/j.bmcl.2009.11.078
2102 7972 21 None -2 2 Human 9.6 pKi = 9.6 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
5311057 7972 21 None -2 2 Human 9.6 pKi = 9.6 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
CHEMBL441225 7972 21 None -2 2 Human 9.6 pKi = 9.6 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
10598278 20696 0 None - 1 Human 9.6 pKi = 9.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 421 7 3 8 2.2 COc1ccc(-n2nnnc2NC(C)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1196442 20696 0 None - 1 Human 9.6 pKi = 9.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 421 7 3 8 2.2 COc1ccc(-n2nnnc2NC(C)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL556981 20696 0 None - 1 Human 9.6 pKi = 9.6 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 421 7 3 8 2.2 COc1ccc(-n2nnnc2NC(C)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
52943331 25021 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 6.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCCC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270271 25021 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 6.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCCC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
52947014 25078 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.4 CNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270664 25078 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.4 CNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
2102 7972 21 None 2 2 Guinea pig 9.6 pKi = 9.6 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
5311057 7972 21 None 2 2 Guinea pig 9.6 pKi = 9.6 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
CHEMBL441225 7972 21 None 2 2 Guinea pig 9.6 pKi = 9.6 Binding
Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigEvaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pig
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00073a022
9852904 123815 0 None 34 3 Human 9.6 pKi = 9.6 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 677 10 1 6 5.9 CNC(=O)C1(N2CCCCC2=O)CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(C#N)cc3ccccc23)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm020094i
CHEMBL339051 123815 0 None 34 3 Human 9.6 pKi = 9.6 Binding
Inhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to Tachykinin receptor 1 of human tachykinin receptor expressed in mouse erythroleukemia cells
ChEMBL 677 10 1 6 5.9 CNC(=O)C1(N2CCCCC2=O)CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(C#N)cc3ccccc23)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm020094i
51002992 64648 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.0 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672050 64648 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.0 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCCC2)CCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
122187724 129844 0 None -17 4 Rat 9.6 pKi = 9.6 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 692 11 5 6 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3609620 129844 0 None -17 4 Rat 9.6 pKi = 9.6 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 692 11 5 6 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
52940937 25049 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 515 6 2 5 5.4 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC2=NCCO2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270465 25049 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 515 6 2 5 5.4 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC2=NCCO2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
10152358 25005 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 6.0 CCC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270174 25005 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 6.0 CCC(=O)N[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL389652 219209 0 None 2 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
CHEMBL389652 219209 0 None -2 4 Rat 9.5 pKi = 9.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL2419541 217221 0 None -3 4 Rat 9.5 pKi = 9.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL389652 219209 0 None -2 4 Rat 9.5 pKi = 9.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
153996 119445 2 None 3 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
CHEMBL330366 119445 2 None 3 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
CHEMBL539021 119445 2 None 3 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against human cloned Tachykinin receptor 1 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 1 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
9831546 211954 0 None -1 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 698 12 1 6 5.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78284 211954 0 None -1 3 Human 9.5 pKi = 9.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 698 12 1 6 5.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL2397481 217195 5 None - 1 Rat 9.5 pKi = 9.5 Binding
Binding affinity to substance P receptor (1 to 7 amino acids) binding site in rat spinal cord membranesBinding affinity to substance P receptor (1 to 7 amino acids) binding site in rat spinal cord membranes
ChEMBL None None None N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
11712457 25122 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 6.5 C[C@@H](OC[C@@]1(c2ccccc2)CCCCN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270970 25122 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 6.5 C[C@@H](OC[C@@]1(c2ccccc2)CCCCN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL2397481 217195 5 None - 1 Rat 9.5 pKi = 9.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2018.06.009
10128086 86601 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 6.5 C[C@@H](OC[C@]1(c2ccccc2)C[C@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL212112 86601 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 6.5 C[C@@H](OC[C@]1(c2ccccc2)C[C@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10128366 87039 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 507 8 1 2 7.7 C[C@@H](OCC1(c2ccccc2)CC(NCc2ccccc2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL213906 87039 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 507 8 1 2 7.7 C[C@@H](OCC1(c2ccccc2)CC(NCc2ccccc2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10128322 179751 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.1 CCC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL451765 179751 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.1 CCC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
10311126 179978 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 4.7 CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452270 179978 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 4.7 CC(=O)N[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
44560775 180052 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.1 CCC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452532 180052 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.1 CCC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
104943 62160 39 None 1862 3 Human 9.5 pKi = 9.5 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
CHEMBL16192 62160 39 None 1862 3 Human 9.5 pKi = 9.5 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
44241723 90307 0 None 12 2 Human 9.5 pKi = 9.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 674 6 0 5 6.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203704 90307 0 None 12 2 Human 9.5 pKi = 9.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 674 6 0 5 6.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10603544 117341 0 None - 1 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 592 9 2 5 5.0 COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL325312 117341 0 None - 1 Human 9.5 pKi = 9.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 592 9 2 5 5.0 COC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
51002995 64654 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 5 1 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672057 64654 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 5 1 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@@H](NC2CC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
52945787 25048 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 5 6.4 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](Nc2ncccn2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270464 25048 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 5 6.4 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](Nc2ncccn2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
23725089 7591 13 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
4401 7591 13 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
5758 7591 13 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
9917021 7591 13 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
CHEMBL1672054 7591 13 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
DB06634 7591 13 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 10.1021/jm1013264
122187205 129781 0 None 1 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 981 22 8 9 5.3 CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3608938 129781 0 None 1 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 981 22 8 9 5.3 CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
52942011 25108 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270868 25108 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
52943450 24987 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270067 24987 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.6 CC(=O)N[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
52946917 25093 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.8 CCNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270766 25093 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.8 CCNC(=O)[C@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
10174642 153326 0 None - 1 Human 9.4 pKi = 9.4 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 516 5 2 4 5.9 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCOC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3922759 153326 0 None - 1 Human 9.4 pKi = 9.4 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 516 5 2 4 5.9 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCOC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
2102 7972 21 None -2 2 Human 9.4 pKi = 9.4 Binding
Binding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell lineBinding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell line
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00581-D
5311057 7972 21 None -2 2 Human 9.4 pKi = 9.4 Binding
Binding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell lineBinding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell line
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00581-D
CHEMBL441225 7972 21 None -2 2 Human 9.4 pKi = 9.4 Binding
Binding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell lineBinding affinity was carried out with NK 1 receptors from U-373MG human astrocytoma cell line
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00581-D
2102 7972 21 None -2 2 Human 9.4 pKi = 9.4 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00552-5
5311057 7972 21 None -2 2 Human 9.4 pKi = 9.4 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00552-5
CHEMBL441225 7972 21 None -2 2 Human 9.4 pKi = 9.4 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00552-5
44408025 82690 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL204979 82690 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
10363623 91654 0 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 400 7 2 4 4.5 COc1ccc(C(=O)c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
CHEMBL22360 91654 0 None - 1 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 400 7 2 4 4.5 COc1ccc(C(=O)c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
15463538 20679 0 None - 1 Human 9.4 pKi = 9.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 440 7 2 7 3.9 COc1ccc(-n2nnnc2-c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1196327 20679 0 None - 1 Human 9.4 pKi = 9.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 440 7 2 7 3.9 COc1ccc(-n2nnnc2-c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL556562 20679 0 None - 1 Human 9.4 pKi = 9.4 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 440 7 2 7 3.9 COc1ccc(-n2nnnc2-c2ccccc2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
102023780 127525 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10417302 127525 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380072 127525 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355041 127525 0 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9852630 211632 0 None 1 3 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 655 10 0 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75598 211632 0 None 1 3 Human 9.4 pKi = 9.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 655 10 0 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
22960738 82059 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 533 6 1 3 5.4 CN1CCC(N2CC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccc(F)cc3)NC2=O)CC1 10.1016/j.bmcl.2005.10.072
CHEMBL203716 82059 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 533 6 1 3 5.4 CN1CCC(N2CC(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)(c3ccc(F)cc3)NC2=O)CC1 10.1016/j.bmcl.2005.10.072
10164354 172780 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 507 7 2 3 4.3 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(CC(N)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL425406 172780 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 507 7 2 3 4.3 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(CC(N)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
18403344 147692 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 1 4 7.0 Cc1ccccc1-c1cc(N2CCC(O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL382242 147692 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 1 4 7.0 Cc1ccccc1-c1cc(N2CCC(O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
52942012 25109 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270869 25109 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 7 2 3 6.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@@H](C(=O)NC2CC2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
10173872 146052 0 None 5370 2 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 459 6 1 2 6.0 CC(=O)N[C@H]1C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
CHEMBL379073 146052 0 None 5370 2 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 459 6 1 2 6.0 CC(=O)N[C@H]1C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
10128086 146302 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 6.5 C[C@@H](OC[C@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL379520 146302 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 485 6 0 2 6.5 C[C@@H](OC[C@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
44560832 183592 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 500 6 1 3 5.7 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL460890 183592 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 500 6 1 3 5.7 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](N2CCCC2)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44560834 196776 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 3 4.5 C[C@@H](OC[C@@]1(c2ccccc2)CC(N)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL517121 196776 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 446 5 2 3 4.5 C[C@@H](OC[C@@]1(c2ccccc2)CC(N)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
104943 62160 39 None 1862 3 Human 9.4 pKi = 9.4 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
CHEMBL16192 62160 39 None 1862 3 Human 9.4 pKi = 9.4 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm2017072
11490769 90311 0 None 6 2 Human 9.4 pKi = 9.4 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 660 6 0 5 6.3 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203708 90311 0 None 6 2 Human 9.4 pKi = 9.4 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 660 6 0 5 6.3 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
9874473 48582 0 None 16 3 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 48582 0 None 16 3 Human 9.4 pKi = 9.4 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
44307758 210335 0 None 1 2 Guinea pig 9.4 pKi = 9.4 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66635 210335 0 None 1 2 Guinea pig 9.4 pKi = 9.4 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10311483 151651 0 None - 1 Human 9.4 pKi = 9.4 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 514 5 2 3 6.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCCC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3909899 151651 0 None - 1 Human 9.4 pKi = 9.4 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 514 5 2 3 6.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CCCC(=O)N2)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL2370435 216628 0 None 48 2 Human 9.4 pKi = 9.4 Binding
Displacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptorDisplacement of radiolabeled [Sar9,Met(O2)11]-SP from human NK1 receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1021/jm8007618
44140365 193818 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL490926 193818 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
10173890 85020 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 460 6 2 3 4.7 C[C@@H](OC[C@]1(c2ccccc2)C[C@@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL210641 85020 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 460 6 2 3 4.7 C[C@@H](OC[C@]1(c2ccccc2)C[C@@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
51003178 64652 6 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 CC(=O)N1CCN([C@@H]2CCN(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1021/jm1013264
CHEMBL1672055 64652 6 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 616 4 0 3 6.7 CC(=O)N1CCN([C@@H]2CCN(C(=O)N(C)[C@H](C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3C)C2)CC1 10.1021/jm1013264
9873032 82157 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 0 5 6.2 Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL203867 82157 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 0 5 6.2 Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL3609615 218608 0 None -2 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
2102 7972 21 None -2 2 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
5311057 7972 21 None -2 2 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
CHEMBL441225 7972 21 None -2 2 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00104a018
44380081 64882 0 None 100 2 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 738 13 1 7 6.3 CN(C/C(=N\OCCN1CCNCC1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167546 64882 0 None 100 2 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 738 13 1 7 6.3 CN(C/C(=N\OCCN1CCNCC1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9810434 111160 0 None 1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 1 6 6.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(C)(C)O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL310273 111160 0 None 1 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 1 6 6.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(C)(C)O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44407938 147224 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 446 5 1 2 5.4 C[C@@H](OC[C@@]1(c2ccccc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL380931 147224 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 446 5 1 2 5.4 C[C@@H](OC[C@@]1(c2ccccc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
52937467 69297 0 None -9 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL1782141 69297 0 None -9 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
52937467 69297 0 None -9 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL1782141 69297 0 None -9 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/acsmedchemlett.5b00359
52937467 69297 0 None -9 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782141 69297 0 None -9 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
135416054 86999 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 8 3 5 5.5 C[C@@H](OCC1(c2ccccc2)CC(NCc2n[nH]c(O)n2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL213735 86999 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 8 3 5 5.5 C[C@@H](OCC1(c2ccccc2)CC(NCc2n[nH]c(O)n2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10151946 87095 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.0 CNC(=O)[C@]1(N)C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
CHEMBL214194 87095 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.0 CNC(=O)[C@]1(N)C[C@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
44560809 180279 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL453055 180279 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.2 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](N2CCCC2=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44560833 183631 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 447 5 2 3 4.6 C[C@@H](OC[C@@]1(c2ccccc2)CC(O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL461299 183631 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 447 5 2 3 4.6 C[C@@H](OC[C@@]1(c2ccccc2)CC(O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44241723 90307 0 None 12 2 Human 9.3 pKi = 9.3 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 674 6 0 5 6.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203704 90307 0 None 12 2 Human 9.3 pKi = 9.3 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 674 6 0 5 6.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)[C@@H](C)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10698493 116556 0 None - 1 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 581 9 3 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL323224 116556 0 None - 1 Human 9.3 pKi = 9.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 581 9 3 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl 10.1021/jm970499g
10522676 125939 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 362 6 2 4 4.5 COc1ccc(-c2ccco2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL342966 125939 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 362 6 2 4 4.5 COc1ccc(-c2ccco2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
10761962 126004 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 6 2 5 2.7 COc1ccc(S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL343404 126004 0 None - 1 Human 9.3 pKi = 9.3 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 374 6 2 5 2.7 COc1ccc(S(C)(=O)=O)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
24969353 205926 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)C1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 10.1016/j.bmcl.2009.11.078
CHEMBL589371 205926 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)C1(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 10.1016/j.bmcl.2009.11.078
46224928 206181 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 515 2 1 2 6.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591074 206181 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 515 2 1 2 6.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
46889695 13701 0 None 2 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@@H](O)C[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084436 13701 0 None 2 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@@H](O)C[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
104974 10248 31 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
2111 10248 31 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
3481 10248 31 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
CHEMBL308148 10248 31 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
DB06660 10248 31 None -1 7 Rat 9.3 pKi = 9.3 Binding
Tested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membraneTested in vitro to inhibit the binding of [125I]NKA to its receptor in rat duodenum membrane
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(01)80901-X
46227361 209362 0 None 14 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611925 209362 0 None 14 4 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
11261795 205481 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL492117 205481 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL581391 205481 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
52943348 25079 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.4 CNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270665 25079 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 5.4 CNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
10462 8797 10 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2005.11.047
9808518 8797 10 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2005.11.047
CHEMBL206488 8797 10 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1016/j.bmcl.2005.11.047
122187205 129781 0 None -1 4 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 981 22 8 9 5.3 CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3608938 129781 0 None -1 4 Rat 9.2 pKi = 9.2 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 981 22 8 9 5.3 CCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
10311496 25033 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 515 6 2 3 5.5 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCNC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270370 25033 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 515 6 2 3 5.5 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](N2CCNC2=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
44380448 127058 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 670 12 1 6 6.4 CN(C/C(=N\OCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352588 127058 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 670 12 1 6 6.4 CN(C/C(=N\OCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315483 103374 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 728 13 2 7 5.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN([C@H](CO)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL263243 103374 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 728 13 2 7 5.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN([C@H](CO)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
101195489 162399 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9875056 162399 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL404599 162399 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9853636 212229 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 762 14 1 7 5.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CCNS(C)(=O)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL80355 212229 0 None -1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 762 14 1 7 5.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CCNS(C)(=O)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
10296442 82281 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL204306 82281 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
24768355 175674 0 None 15 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL438389 175674 0 None 15 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10296442 82281 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL204306 82281 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
44560773 179748 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 4.1 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL451763 179748 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 4.1 C[C@@H](OC[C@@]1(c2ccccc2)C[C@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
10194796 198634 0 None 6309 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 5.6 C[C@@H](OC[C@@]1(c2ccccc2)CCC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL519914 198634 0 None 6309 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 431 5 1 2 5.6 C[C@@H](OC[C@@]1(c2ccccc2)CCC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL439019 220597 0 None 3 3 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
52940879 25100 0 None 489 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 563 6 2 3 4.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)NCCO)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL1270786 25100 0 None 489 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 563 6 2 3 4.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)NCCO)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
44307773 109137 0 None 17 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL303803 109137 0 None 17 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307757 210315 0 None 1 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66441 210315 0 None 1 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
46889696 13702 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@H](O)C[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084437 13702 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2C[C@H](O)C[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
24768355 175674 0 None 15 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
CHEMBL438389 175674 0 None 15 5 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
71458106 86374 0 None - 1 Human 9.2 pKi = 9.2 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 348 5 2 3 4.0 COc1ccccc1CN[C@H]1C2CCNC1(c1ccccc1)CC=C2C 10.1016/0960-894X(95)00552-5
CHEMBL2114439 86374 0 None - 1 Human 9.2 pKi = 9.2 Binding
Compound was evaluated for binding affinity towards neurokinin NK1 receptor.Compound was evaluated for binding affinity towards neurokinin NK1 receptor.
ChEMBL 348 5 2 3 4.0 COc1ccccc1CN[C@H]1C2CCNC1(c1ccccc1)CC=C2C 10.1016/0960-894X(95)00552-5
51003117 64647 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672049 64647 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 545 4 0 2 7.2 Cc1cc(F)ccc1[C@H]1C[C@H](N2CCC2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
10311306 10140 52 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
5027 10140 52 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
5749 10140 52 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
CHEMBL3707331 10140 52 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
DB09291 10140 52 None - 1 Human 9.2 pKi = 9.2 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 nan
104943 62160 39 None 1862 3 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
CHEMBL16192 62160 39 None 1862 3 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
10128131 25022 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 489 6 3 3 5.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270272 25022 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 489 6 3 3 5.1 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NC(N)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
44380337 64209 0 None 6 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 735 14 0 8 7.1 CN(C/C(=N\OCCCn1cncn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL165465 64209 0 None 6 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 735 14 0 8 7.1 CN(C/C(=N\OCCCn1cncn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380396 64494 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166921 64494 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380082 64889 0 None 12 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 683 13 1 6 6.7 CN(C/C(=N\OCCCN)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167606 64889 0 None 12 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 683 13 1 6 6.7 CN(C/C(=N\OCCCN)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380091 127499 0 None 2 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 13 1 6 6.8 CN(C/C(=N\OCCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354772 127499 0 None 2 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 13 1 6 6.8 CN(C/C(=N\OCCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380473 127562 0 None 549 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 12 1 6 6.5 CN(C/C(=N\OCC(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355429 127562 0 None 549 2 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 12 1 6 6.5 CN(C/C(=N\OCC(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9896757 211760 0 None 1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 732 12 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76580 211760 0 None 1 3 Human 9.2 pKi = 9.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 732 12 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44241710 90306 1 None 3 2 Human 9.2 pKi = 9.2 Binding
Binding affinity at human NK1 receptorBinding affinity at human NK1 receptor
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203703 90306 1 None 3 2 Human 9.2 pKi = 9.2 Binding
Binding affinity at human NK1 receptorBinding affinity at human NK1 receptor
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44314480 109716 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL306311 109716 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
10127439 179877 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 445 5 1 2 5.9 C[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452022 179877 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 445 5 1 2 5.9 C[C@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
44241710 90306 1 None 3 2 Human 9.2 pKi = 9.2 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203703 90306 1 None 3 2 Human 9.2 pKi = 9.2 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
71452185 90310 0 None -2 2 Human 9.2 pKi = 9.2 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203707 90310 0 None -2 2 Human 9.2 pKi = 9.2 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10817360 11965 0 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL106078 11965 0 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
10769059 115394 0 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 10.1021/jm970499g
CHEMBL320581 115394 0 None - 1 Human 9.2 pKi = 9.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(F)c1 10.1021/jm970499g
44307898 208252 0 None -1 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL60504 208252 0 None -1 2 Guinea pig 9.2 pKi = 9.2 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL387670 219190 0 None 109 3 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CCCC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061369n
132837 9018 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
9461 9018 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
CHEMBL22870 9018 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
132837 9018 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
9461 9018 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
CHEMBL22870 9018 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
132837 9018 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
9461 9018 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
CHEMBL22870 9018 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
132837 9018 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
132837 9018 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
9461 9018 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
9461 9018 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
CHEMBL22870 9018 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
CHEMBL22870 9018 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
132837 9018 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
9461 9018 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
CHEMBL22870 9018 55 None 18 5 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
10128485 155366 11 None - 1 Human 9.1 pKi = 9.1 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 515 5 3 4 4.7 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CN1)NC(=O)NC2=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3939059 155366 11 None - 1 Human 9.1 pKi = 9.1 Binding
Antagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P bindingAntagonist activity at NK1 receptor (unknown origin) assessed as inhibition of substance P binding
ChEMBL 515 5 3 4 4.7 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@]2(CN1)NC(=O)NC2=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
11296094 13203 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 573 7 1 4 6.8 CN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1082415 13203 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 573 7 1 4 6.8 CN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
2102 7972 21 None -2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
5311057 7972 21 None -2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
CHEMBL441225 7972 21 None -2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00481-8
10621261 43304 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 404 6 2 5 4.3 COc1ccc(-c2c(C)nn(C)c2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL144793 43304 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 404 6 2 5 4.3 COc1ccc(-c2c(C)nn(C)c2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
9929728 46536 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 379 6 2 5 4.4 COc1ccc(-c2nccs2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL147619 46536 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 379 6 2 5 4.4 COc1ccc(-c2nccs2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
44408039 82277 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 569 8 2 5 4.9 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN 10.1016/j.bmcl.2005.10.077
CHEMBL204297 82277 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 569 8 2 5 4.9 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN 10.1016/j.bmcl.2005.10.077
44408047 103543 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 597 9 1 5 5.5 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C 10.1016/j.bmcl.2005.10.077
CHEMBL264660 103543 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 597 9 1 5 5.5 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN(C)C 10.1016/j.bmcl.2005.10.077
46224962 206183 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 518 2 2 3 5.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591076 206183 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 518 2 2 3 5.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
10476340 101784 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 404 6 2 5 4.5 COc1ccc(C2(C(F)(F)F)N=N2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
CHEMBL25492 101784 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligandIn vitro binding affinity against human NK1 receptor expressed in CHO cells using [3H]-substance P as radioligand
ChEMBL 404 6 2 5 4.5 COc1ccc(C2(C(F)(F)F)N=N2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(95)00207-A
44380206 64546 0 None 1 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 658 11 0 5 7.3 CN(C/C(=N\OCF)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166961 64546 0 None 1 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 658 11 0 5 7.3 CN(C/C(=N\OCF)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380132 103202 0 None 4 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 730 14 0 6 7.2 CN(C/C(=N\OCCC[S+](C)[O-])C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL262053 103202 0 None 4 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 730 14 0 6 7.2 CN(C/C(=N\OCCC[S+](C)[O-])C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380290 106866 0 None 21 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 736 14 0 9 6.5 CN(C/C(=N\OCCCn1cnnn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL287369 106866 0 None 21 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 736 14 0 9 6.5 CN(C/C(=N\OCCCn1cnnn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9961955 179552 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 726 11 0 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL451235 179552 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 726 11 0 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9810544 211571 0 None -2 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 726 12 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)(C)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL74956 211571 0 None -2 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 726 12 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)(C)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44408107 82069 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 478 6 1 2 5.9 CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)NC1=O 10.1016/j.bmcl.2005.10.072
CHEMBL203740 82069 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 478 6 1 2 5.9 CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)NC1=O 10.1016/j.bmcl.2005.10.072
CHEMBL389651 219208 0 None 6 3 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
135413536 7236 85 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
230 7236 85 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
3490 7236 85 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
6918365 7236 85 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
CHEMBL1471 7236 85 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
DB00673 7236 85 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
10817013 16028 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O 10.1021/jm970499g
CHEMBL110770 16028 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(N)=O 10.1021/jm970499g
44307821 108891 0 None 4 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL302329 108891 0 None 4 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307819 109373 0 None 1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL304106 109373 0 None 1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307677 176043 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL441252 176043 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307820 210414 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67171 210414 0 None -1 2 Guinea pig 9.1 pKi = 9.1 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
11734825 19999 0 None 549 2 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL119126 19999 0 None 549 2 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
122187725 129845 0 None 2 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 691 11 6 5 4.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3609621 129845 0 None 2 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor transfected in CHO cells
ChEMBL 691 11 6 5 4.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
46889690 13723 0 None 9 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 585 5 1 4 7.0 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084522 13723 0 None 9 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 585 5 1 4 7.0 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL2371977 216950 0 None 17 3 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
CHEMBL2419540 217220 0 None 4 4 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
10530375 12401 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 10.1021/jm970499g
CHEMBL107763 12401 0 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 534 8 2 3 5.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1 10.1021/jm970499g
44380131 64387 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 746 14 0 7 6.8 CN(C/C(=N\OCCCS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166828 64387 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 746 14 0 7 6.8 CN(C/C(=N\OCCCS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380415 127093 0 None 2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 683 12 1 6 5.9 CN(C/C(=N\OCC(N)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352813 127093 0 None 2 2 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 683 12 1 6 5.9 CN(C/C(=N\OCC(N)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9831674 111188 0 None 1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 712 12 1 6 5.9 CNC(=O)CN1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
CHEMBL310334 111188 0 None 1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 712 12 1 6 5.9 CNC(=O)CN1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
9917970 211732 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 683 11 0 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76437 211732 0 None -1 3 Human 9.1 pKi = 9.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 683 11 0 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44337201 115389 0 None 7 3 Human 9.1 pKi = 9.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320548 115389 0 None 7 3 Human 9.1 pKi = 9.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44299271 202827 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/s0960-894x(00)00463-7
CHEMBL56038 202827 0 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 510 10 2 3 5.5 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1 10.1016/s0960-894x(00)00463-7
10231172 146043 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 519 6 2 3 5.1 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCNCC1 10.1016/j.bmcl.2005.10.072
CHEMBL379038 146043 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 519 6 2 3 5.1 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCNCC1 10.1016/j.bmcl.2005.10.072
44560755 179979 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 4.7 CC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452271 179979 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 2 3 4.7 CC(=O)N[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
52946919 25099 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 476 4 1 2 5.4 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CNC[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL1270785 25099 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 476 4 1 2 5.4 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CNC[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
46889697 13703 0 None 32 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 643 8 0 5 7.6 COC[C@@H]1C[C@@H](OC)CN1c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1084438 13703 0 None 32 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 643 8 0 5 7.6 COC[C@@H]1C[C@@H](OC)CN1c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
51003055 64644 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 533 4 0 2 7.1 Cc1cc(F)ccc1[C@H]1C[C@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
CHEMBL1672046 64644 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting
ChEMBL 533 4 0 2 7.1 Cc1cc(F)ccc1[C@H]1C[C@H](N(C)C)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1013264
4898 9541 86 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
5742 9541 86 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
6451149 9541 86 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
CHEMBL206253 9541 86 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
DB09048 9541 86 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 10.1016/j.bmcl.2005.11.047
54581461 68037 0 None -6 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
CHEMBL1766207 68037 0 None -6 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
127032533 145565 0 None 10 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1108 22 9 10 4.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCN([C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)CC1 10.1021/acsmedchemlett.5b00359
CHEMBL3780776 145565 0 None 10 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1108 22 9 10 4.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCN([C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)CC1 10.1021/acsmedchemlett.5b00359
71716116 93136 0 None 537 2 Human 9.0 pKi = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 516 7 0 6 5.7 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)OCC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1021/jm301653f
CHEMBL2313630 93136 0 None 537 2 Human 9.0 pKi = 9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 516 7 0 6 5.7 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)OCC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1021/jm301653f
44380062 127542 0 None 1 2 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 740 14 2 6 6.7 CNC(=O)NCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355295 127542 0 None 1 2 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 740 14 2 6 6.7 CNC(=O)NCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
9961936 109866 0 None -1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 723 12 1 8 5.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3nn[nH]n3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307498 109866 0 None -1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 723 12 1 8 5.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3nn[nH]n3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44315370 211618 0 None 1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 789 14 0 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=O)OCc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75479 211618 0 None 1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 789 14 0 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=O)OCc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9831075 211932 0 None -1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 657 10 1 6 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78132 211932 0 None -1 3 Human 9.0 pKi = 9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 657 10 1 6 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
5759 7381 24 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 10.1016/j.bmcl.2005.11.047
6450815 7381 24 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 10.1016/j.bmcl.2005.11.047
CHEMBL204694 7381 24 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 10.1016/j.bmcl.2005.11.047
44338517 13107 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL108200 13107 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44358516 175354 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 1 3 5.2 Cc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
CHEMBL435796 175354 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 1 3 5.2 Cc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
44346206 120438 3 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL332284 120438 3 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 417 5 1 2 5.9 FC(F)(F)c1cc(COCC2(c3ccccc3)CCCCN2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
145948847 174259 0 None -1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1123 22 9 9 5.5 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299423 174259 0 None -1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1123 22 9 9 5.5 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10173890 85004 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 460 6 2 3 4.7 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL210591 85004 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 460 6 2 3 4.7 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(N)=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10151946 87140 0 None 1995 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.0 CNC(=O)[C@]1(N)C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
CHEMBL214388 87140 0 None 1995 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 474 6 2 3 5.0 CNC(=O)[C@]1(N)C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 10.1016/j.bmcl.2006.04.031
46889693 13724 0 None -1 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 6 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084523 13724 0 None -1 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 6 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44177670 68036 0 None -1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766206 68036 0 None -1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL426363 220124 0 None 26 3 Human 9.0 pKi = 9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
11801327 16128 0 None - 1 Human 9.0 pKi = 9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 10 2 4 5.4 COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL111295 16128 0 None - 1 Human 9.0 pKi = 9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 10 2 4 5.4 COCc1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
44307953 175973 0 None 35 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL440679 175973 0 None 35 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL540651 175973 0 None 35 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9875181 178122 0 None 7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL446146 178122 0 None 7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9810835 210354 0 None 7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66763 210354 0 None 7 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874206 210550 0 None 1 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 210550 0 None 1 2 Guinea pig 9.0 pKi = 9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10762277 20253 0 None - 1 Human 9.0 pKi = 9 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 379 6 3 8 1.8 COc1ccc(-n2nnnc2N)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL1193282 20253 0 None - 1 Human 9.0 pKi = 9 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 379 6 3 8 1.8 COc1ccc(-n2nnnc2N)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
CHEMBL544660 20253 0 None - 1 Human 9.0 pKi = 9 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 379 6 3 8 1.8 COc1ccc(-n2nnnc2N)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/0960-894X(96)00163-1
44281977 116171 0 None 1 2 Human 9.0 pKi = 9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 595 10 1 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32197 116171 0 None 1 2 Human 9.0 pKi = 9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 595 10 1 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
52949509 25034 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NS(C)(=O)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
CHEMBL1270371 25034 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 5.0 C[C@@H](OC[C@@]1(c2ccccc2)CC[C@H](NS(C)(=O)=O)CN1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2010.08.059
2098 10466 36 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
36511 10466 36 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
3805 10466 36 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
3835 10466 36 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
CHEMBL235363 10466 36 None -1 6 Rat 9.0 pKi = 9.0 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None None 10.1021/jm00391a046
44315298 109888 0 None 1 3 Human 9.0 pKi = 9.0 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 721 12 0 6 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccoc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307733 109888 0 None 1 3 Human 9.0 pKi = 9.0 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 721 12 0 6 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccoc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL2372071 216957 12 None - 1 Human 9.0 pKi = 9.0 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1016/s0960-894x(98)00219-4
9808347 147540 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 0 5 6.2 Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL381832 147540 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 579 5 0 5 6.2 Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
127030411 145570 0 None 48 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1053 22 9 9 5.2 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N(C)[C@@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C[C@@H]1c1ccccc1 10.1021/acsmedchemlett.5b00359
CHEMBL3780820 145570 0 None 48 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1053 22 9 9 5.2 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N(C)[C@@H]1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C[C@@H]1c1ccccc1 10.1021/acsmedchemlett.5b00359
52946726 24931 0 None 173 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 607 8 2 4 4.5 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N(CCO)CCO)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL1269638 24931 0 None 173 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 607 8 2 4 4.5 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N(CCO)CCO)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL2419537 217217 0 None -32 4 Rat 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
44241710 90306 1 None 3 2 Human 9.0 pKi = 9.0 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203703 90306 1 None 3 2 Human 9.0 pKi = 9.0 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 613 6 2 5 6.1 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
104943 62160 39 None 1862 3 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
CHEMBL16192 62160 39 None 1862 3 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
10650495 114196 0 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N 10.1021/jm970499g
CHEMBL318085 114196 0 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C#N 10.1021/jm970499g
10626666 115972 0 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 10.1021/jm970499g
CHEMBL321554 115972 0 None - 1 Human 9.0 pKi = 9.0 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 10.1021/jm970499g
44307741 210566 0 None 15 2 Guinea pig 9.0 pKi = 9.0 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68234 210566 0 None 15 2 Guinea pig 9.0 pKi = 9.0 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10303099 14049 0 None 9 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 7 2 4 6.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(NCCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1086003 14049 0 None 9 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 559 7 2 4 6.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(NCCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
52940877 25094 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.8 CCNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
CHEMBL1270767 25094 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]SAr-Met from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 502 7 2 3 5.8 CCNC(=O)[C@@H]1CC[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1 10.1016/j.bmcl.2010.08.059
44216236 13279 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 603 9 2 5 6.2 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1082737 13279 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 603 9 2 5 6.2 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44380279 64593 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 761 15 1 7 6.3 CN(C/C(=N\OCCCNS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166975 64593 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 761 15 1 7 6.3 CN(C/C(=N\OCCCNS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380414 64929 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 699 12 2 7 5.9 CN(C/C(=N\OCC(=O)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167994 64929 0 None 3 2 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 699 12 2 7 5.9 CN(C/C(=N\OCC(=O)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315421 112505 0 None 2 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 765 14 1 8 7.4 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL312612 112505 0 None 2 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 765 14 1 8 7.4 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
15508105 211610 0 None -1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 675 10 1 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75422 211610 0 None -1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 675 10 1 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
127033167 145531 0 None 33 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1067 23 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
CHEMBL3780408 145531 0 None 33 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1067 23 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
9874206 210550 0 None 1 2 Guinea pig 8.9 pKi = 8.9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 210550 0 None 1 2 Guinea pig 8.9 pKi = 8.9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874473 48582 0 None 16 3 Human 8.9 pKi = 8.9 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 48582 0 None 16 3 Human 8.9 pKi = 8.9 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
44407998 82273 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 639 10 1 6 5.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL204262 82273 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 639 10 1 6 5.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44408046 147522 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381814 147522 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 11 1 6 6.1 C/C(CCCN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44407971 147532 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 625 9 1 6 4.9 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL381822 147532 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 625 9 1 6 4.9 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C=N\OCCN2CCOCC2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44358335 33636 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 1 4 5.2 C[C@H](OC[C@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL136347 33636 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 1 4 5.2 C[C@H](OC[C@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
10437488 36699 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 548 11 1 5 5.3 C[C@H](OC[C@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL138824 36699 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 548 11 1 5 5.3 C[C@H](OC[C@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
20599018 206182 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 517 2 1 2 6.5 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591075 206182 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 517 2 1 2 6.5 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
9826304 193794 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1C1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL490755 193794 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1C1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
2106 10319 4 None -5 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
9875034 10319 4 None -5 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
CHEMBL77023 10319 4 None -5 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
44315390 211821 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 733 12 1 8 7.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL77042 211821 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 733 12 1 8 7.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44315576 212024 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 12 0 9 7.2 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)OC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78851 212024 0 None 1 3 Human 8.9 pKi = 8.9 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 12 0 9 7.2 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)OC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
10304406 147118 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 613 5 0 5 6.3 Cc1ccccc1-c1cc(N2CCS(=O)(=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL380705 147118 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 613 5 0 5 6.3 Cc1ccccc1-c1cc(N2CCS(=O)(=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
155551678 182211 0 None -4 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranesDisplacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranes
ChEMBL 697 12 1 6 6.9 CNC(=O)C[C@H]1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1021/acs.jmedchem.9b00017
CHEMBL4576324 182211 0 None -4 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranesDisplacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranes
ChEMBL 697 12 1 6 6.9 CNC(=O)C[C@H]1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1021/acs.jmedchem.9b00017
10218122 145161 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 6.2 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL377242 145161 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 528 6 1 3 6.2 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
10239346 145521 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.9 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL378027 145521 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 514 6 1 3 5.9 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N2CCCC2)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
71452185 90310 0 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203707 90310 0 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 690 7 1 6 5.6 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
71453994 90309 0 None 10 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 583 5 1 4 6.7 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203706 90309 0 None 10 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 583 5 1 4 6.7 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44307679 210296 0 None -1 2 Guinea pig 8.9 pKi = 8.9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL66332 210296 0 None -1 2 Guinea pig 8.9 pKi = 8.9 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
46889667 13645 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 617 10 2 5 6.6 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084165 13645 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 617 10 2 5 6.6 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N(CCO)CCCO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
9872249 83325 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 549 5 0 3 6.7 Cc1ccccc1-c1cc(N2CCN(C)CC2)ccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206171 83325 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 549 5 0 3 6.7 Cc1ccccc1-c1cc(N2CCN(C)CC2)ccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
127031644 145612 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1007 16 7 8 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3781336 145612 0 None -1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1007 16 7 8 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
127033173 145622 0 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1062 16 7 9 5.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3781519 145622 0 None -2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1062 16 7 9 5.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O 10.1021/acsmedchemlett.5b00359
145948797 174255 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1105 22 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299390 174255 0 None -1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1105 22 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
24768356 162641 0 None 4 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
CHEMBL406030 162641 0 None 4 3 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
52943089 24932 0 None 263 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 630 4 0 3 5.4 CC(=O)N1CCN(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2010.08.138
CHEMBL1269639 24932 0 None 263 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 630 4 0 3 5.4 CC(=O)N1CCN(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)C(C)(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 10.1016/j.bmcl.2010.08.138
11490769 90311 0 None 6 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 660 6 0 5 6.3 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203708 90311 0 None 6 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 660 6 0 5 6.3 Cc1cc(F)ccc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
71457524 90308 0 None -5 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203705 90308 0 None -5 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
71455736 90312 0 None 6 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 687 5 0 6 6.9 Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203709 90312 0 None 6 2 Human 8.9 pKi = 8.9 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 687 5 0 6 6.9 Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44380526 65102 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 665 11 0 6 6.9 CN(C/C(=N\OCC#N)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168272 65102 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 665 11 0 6 6.9 CN(C/C(=N\OCC#N)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315369 109796 0 None 1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 689 10 0 7 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(C)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306952 109796 0 None 1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 689 10 0 7 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(C)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44305818 21567 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1206764 21567 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL305119 21567 0 None 1 4 Human 8.8 pKi = 8.8 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
85169 13687 10 None 2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
CHEMBL108438 13687 10 None 2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
85169 13687 10 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
CHEMBL108438 13687 10 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
10204249 82339 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 450 5 2 2 5.1 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL204554 82339 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 450 5 2 2 5.1 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
85169 13687 10 None -2 2 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL108438 13687 10 None -2 2 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
85169 13687 10 None -2 2 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2018.06.009
CHEMBL108438 13687 10 None -2 2 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2018.06.009
44233410 202373 0 None 38 3 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 28 14 16 1.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL555504 202373 0 None 38 3 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 28 14 16 1.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
2102 7972 21 None -2 2 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80386-3
5311057 7972 21 None -2 2 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80386-3
CHEMBL441225 7972 21 None -2 2 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1016/S0960-894X(01)80386-3
44307678 205454 0 None 1 2 Guinea pig 8.8 pKi = 8.8 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL57993 205454 0 None 1 2 Guinea pig 8.8 pKi = 8.8 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
46889694 13348 0 None 4 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 6 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1083052 13348 0 None 4 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 6 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCC[C@@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
46889698 13704 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084439 13704 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 615 6 2 5 6.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@H](O)[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44407902 82199 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 652 9 1 6 5.2 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 10.1016/j.bmcl.2005.10.077
CHEMBL204114 82199 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 652 9 1 6 5.2 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCN(C)CC1 10.1016/j.bmcl.2005.10.077
44338518 14494 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL108889 14494 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2ccccc2Cl)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
22353151 15903 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL109937 15903 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44358612 37975 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 0 3 5.2 CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL140080 37975 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 0 3 5.2 CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358249 123328 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 484 8 1 3 6.2 C=Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1C=C 10.1016/s0960-894x(02)00956-3
CHEMBL336305 123328 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 484 8 1 3 6.2 C=Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1C=C 10.1016/s0960-894x(02)00956-3
44338359 170208 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL419742 170208 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 466 6 1 3 5.5 FC(F)(F)c1cc(COCC(c2cccc(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44380338 127254 0 None 4 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354196 127254 0 None 4 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315297 211646 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 833 15 1 8 8.0 CCOC(=O)[C@@H](Cc1ccc(O)cc1)N1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
CHEMBL75698 211646 0 None -1 3 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 833 15 1 8 8.0 CCOC(=O)[C@@H](Cc1ccc(O)cc1)N1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
CHEMBL589979 222580 11 None - 1 Rat 8.8 pKi = 8.8 Binding
Binding affinity to substance P receptor (1 to 7 amino acids) binding site in rat spinal cord membranesBinding affinity to substance P receptor (1 to 7 amino acids) binding site in rat spinal cord membranes
ChEMBL None None None None 10.1021/jm400209h
2098 10466 36 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
36511 10466 36 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
3805 10466 36 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
3835 10466 36 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
CHEMBL235363 10466 36 None 1 6 Human 8.8 pKi = 8.8 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
22960739 82385 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 533 8 1 3 5.4 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1CCN1CCCC1 10.1016/j.bmcl.2005.10.072
CHEMBL204714 82385 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 533 8 1 3 5.4 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1CCN1CCCC1 10.1016/j.bmcl.2005.10.072
44177770 129780 0 None -31 4 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 939 20 8 9 4.1 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3608937 129780 0 None -31 4 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 939 20 8 9 4.1 C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL589979 222580 11 None - 1 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL589979 222580 11 None - 1 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
24768354 104742 0 None 28 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 955 22 8 9 3.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 10.1021/jm070332f
CHEMBL272665 104742 0 None 28 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 955 22 8 9 3.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1ccccc1 10.1021/jm070332f
CHEMBL2419543 217223 0 None -16 4 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
CHEMBL261390 217297 0 None -34 3 Rat 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
71461646 85684 0 None 2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 0 5 7.6 CN(C/C(=N\OC(F)F)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL2112941 85684 0 None 2 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 0 5 7.6 CN(C/C(=N\OC(F)F)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380289 127033 0 None 14 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1cccn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352364 127033 0 None 14 2 Human 8.8 pKi = 8.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1cccn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44407939 82133 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 460 6 1 2 5.7 CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2005.10.072
CHEMBL203753 82133 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 460 6 1 2 5.7 CCN1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2005.10.072
9850565 82969 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 551 5 0 5 5.5 Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL205829 82969 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 551 5 0 5 5.5 Cc1ccccc1-c1nc(N2CCN(C)CC2)ncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44408838 148044 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 Cc1ccccc1-c1cnc(N2CCN(C)CC2)cc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL383125 148044 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 Cc1ccccc1-c1cnc(N2CCN(C)CC2)cc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
71455736 90312 0 None 6 2 Human 8.8 pKi = 8.8 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 687 5 0 6 6.9 Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203709 90312 0 None 6 2 Human 8.8 pKi = 8.8 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 687 5 0 6 6.9 Cc1cc(F)ccc1-c1cc(N2CCC3(CC2)OCCS3(=O)=O)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
10745532 16003 0 None - 1 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 564 9 3 4 4.7 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1CO 10.1021/jm970499g
CHEMBL110656 16003 0 None - 1 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 564 9 3 4 4.7 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1CO 10.1021/jm970499g
10555763 114819 0 None - 1 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 612 9 1 3 6.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL319476 114819 0 None - 1 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 612 9 1 3 6.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
9874473 48582 0 None 16 3 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 48582 0 None 16 3 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
46889668 13347 0 None 8 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 5 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC(O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1083051 13347 0 None 8 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 599 5 1 4 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC(O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44380080 19014 0 None 323 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL1184507 19014 0 None 323 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352842 19014 0 None 323 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10145229 15945 0 None 2 4 Human 8.7 pKi = 8.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110219 15945 0 None 2 4 Human 8.7 pKi = 8.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44337370 114193 0 None 147 2 Human 8.7 pKi = 8.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL318081 114193 0 None 147 2 Human 8.7 pKi = 8.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
101658885 168267 0 None - 1 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 899 27 12 12 -3.5 N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2018.06.009
CHEMBL4127872 168267 0 None - 1 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 899 27 12 12 -3.5 N=C(N)NCCC[C@H](N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2018.06.009
44233184 201547 0 None 12 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL538131 201547 0 None 12 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
44380092 127139 0 None 12 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 1 6 7.2 CN(C/C(=N\OCC(C)(C)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL353162 127139 0 None 12 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 1 6 7.2 CN(C/C(=N\OCC(C)(C)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44315589 211617 0 None 2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75478 211617 0 None 2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
9831707 211806 0 None -3 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 718 11 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(c3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76965 211806 0 None -3 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 718 11 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(c3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
127033168 145552 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1021 17 7 8 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3780686 145552 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1021 17 7 8 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O 10.1021/acsmedchemlett.5b00359
44315589 211617 0 None 2 3 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranesDisplacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranes
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1021/acs.jmedchem.9b00017
CHEMBL75478 211617 0 None 2 3 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranesDisplacement of [3H]Sar SP from human NK1 receptor expressed in CHO cells membranes
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1021/acs.jmedchem.9b00017
49863734 22105 0 None 13 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214027 22105 0 None 13 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
11793946 45002 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 376 6 2 5 3.7 COc1ccc(-c2nccn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL146210 45002 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 376 6 2 5 3.7 COc1ccc(-c2nccn2C)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
44408045 82381 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 583 9 2 5 5.2 CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL204691 82381 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 583 9 2 5 5.2 CNCCO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44358318 37019 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL139088 37019 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
22353158 37656 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 476 8 1 4 4.6 OCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139750 37656 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 476 8 1 4 4.6 OCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358456 125671 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 523 8 0 4 6.2 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3ccccn3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL342266 125671 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 523 8 0 4 6.2 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3ccccn3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
10741553 20268 0 None - 1 Human 8.7 pKi = 8.7 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 435 9 2 8 3.1 CCN(CC)c1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL1193479 20268 0 None - 1 Human 8.7 pKi = 8.7 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 435 9 2 8 3.1 CCN(CC)c1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
CHEMBL544892 20268 0 None - 1 Human 8.7 pKi = 8.7 Binding
Inhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cellsInhibition of [3H]-substance P binding to human NK1 receptor expressed in chinese hamster ovary cells
ChEMBL 435 9 2 8 3.1 CCN(CC)c1nnnn1-c1ccc(OC)c(CN[C@H]2CCCN[C@H]2c2ccccc2)c1 10.1016/0960-894X(96)00163-1
9892922 107680 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity to NK1 receptorBinding affinity to NK1 receptor
ChEMBL 521 3 1 2 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1021/jm1016285
CHEMBL293844 107680 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity to NK1 receptorBinding affinity to NK1 receptor
ChEMBL 521 3 1 2 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1021/jm1016285
44215305 126032 0 None 1 2 Human 8.0 pKi = 8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 695 12 0 5 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL343627 126032 0 None 1 2 Human 8.0 pKi = 8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 695 12 0 5 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44407907 82472 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL204764 82472 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44407917 103333 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 617 8 1 5 6.6 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 10.1016/j.bmcl.2005.10.077
CHEMBL262989 103333 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 617 8 1 5 6.6 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCc1ccccn1 10.1016/j.bmcl.2005.10.077
44408088 146603 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 639 9 1 6 5.3 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL379898 146603 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 639 9 1 6 5.3 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44358568 37468 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 489 8 1 4 4.1 NC(=O)CN1CCN([C@@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139499 37468 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 489 8 1 4 4.1 NC(=O)CN1CCN([C@@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
10302076 37506 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 532 11 1 4 5.9 O=C(O)CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139531 37506 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 532 11 1 4 5.9 O=C(O)CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
9892922 107680 0 None - 1 Human 8.0 pKi = 8 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 521 3 1 2 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1016/S0960-894X(97)00353-3
CHEMBL293844 107680 0 None - 1 Human 8.0 pKi = 8 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 521 3 1 2 6.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1016/S0960-894X(97)00353-3
44281685 106807 0 None -5 2 Human 8.0 pKi = 8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 587 10 1 6 6.6 CO/N=C(\CN(C)C(=O)c1ccc(C)s1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286901 106807 0 None -5 2 Human 8.0 pKi = 8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 587 10 1 6 6.6 CO/N=C(\CN(C)C(=O)c1ccc(C)s1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281538 117090 0 None 1 2 Human 8.0 pKi = 8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 696 11 1 5 8.2 CO/N=C(\COCc1cc(Br)cc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32385 117090 0 None 1 2 Human 8.0 pKi = 8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 696 11 1 5 8.2 CO/N=C(\COCc1cc(Br)cc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
3082491 206096 20 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 277 7 3 3 0.6 CC(C)C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
CHEMBL590518 206096 20 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 277 7 3 3 0.6 CC(C)C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
CHEMBL58178 222558 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None C[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
CHEMBL591489 222581 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1 10.1021/jm901352b
44380277 66019 0 None 2 2 Human 7.0 pKi = 7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 702 13 1 5 9.3 C=CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL170325 66019 0 None 2 2 Human 7.0 pKi = 7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 702 13 1 5 9.3 C=CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
73212439 111384 0 None 10 2 Human 7.0 pKi = 7 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 545 8 2 4 4.3 CC(C)(C(=O)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104782 111384 0 None 10 2 Human 7.0 pKi = 7 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 545 8 2 4 4.3 CC(C)(C(=O)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
44338531 16130 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 408 6 1 3 5.4 CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 10.1016/s0960-894x(02)00956-3
CHEMBL111304 16130 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 408 6 1 3 5.4 CC(C)(C)c1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(C)(C)C)c1 10.1016/s0960-894x(02)00956-3
44358346 33559 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 364 6 1 3 4.2 Clc1ccc(COCC(c2ccccc2)N2CCNCC2)cc1Cl 10.1016/s0960-894x(02)00956-3
CHEMBL136279 33559 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 364 6 1 3 4.2 Clc1ccc(COCC(c2ccccc2)N2CCNCC2)cc1Cl 10.1016/s0960-894x(02)00956-3
46224962 206183 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 518 2 2 3 5.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591076 206183 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 518 2 2 3 5.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCNC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL261608 217298 0 None -3 3 Human 7.0 pKi = 7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm070332f
44281332 119687 0 None -100 2 Human 7.0 pKi = 7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 588 11 1 8 6.4 CO/N=C(\COCc1noc(C(C)(C)C)n1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33106 119687 0 None -100 2 Human 7.0 pKi = 7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 588 11 1 8 6.4 CO/N=C(\COCc1noc(C(C)(C)C)n1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44304397 210065 0 None - 1 Human 6.0 pKi = 6 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 473 2 0 2 5.3 CC1c2ccccc2N(C)C(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
CHEMBL64698 210065 0 None - 1 Human 6.0 pKi = 6 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 473 2 0 2 5.3 CC1c2ccccc2N(C)C(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
44304302 210101 0 None - 1 Human 6.0 pKi = 6 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 385 3 1 2 4.3 CN(Cc1ccccc1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1016/S0960-894X(97)00353-3
CHEMBL64862 210101 0 None - 1 Human 6.0 pKi = 6 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 385 3 1 2 4.3 CN(Cc1ccccc1)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1 10.1016/S0960-894X(97)00353-3
45379600 205956 0 None - 1 Rat 5.0 pKi = 5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 355 8 3 4 1.1 COc1ccc(C[C@H](N)C(=O)N[C@@H](Cc2ccccc2C)C(N)=O)cc1 10.1021/jm901352b
CHEMBL589543 205956 0 None - 1 Rat 5.0 pKi = 5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 355 8 3 4 1.1 COc1ccc(C[C@H](N)C(=O)N[C@@H](Cc2ccccc2C)C(N)=O)cc1 10.1021/jm901352b
57391133 75142 0 None 1 2 Human 4.0 pKi = 4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916635 75142 0 None 1 2 Human 4.0 pKi = 4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
11799987 12090 0 None - 1 Human 6.0 pKi = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 514 9 2 3 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1 10.1021/jm970499g
CHEMBL106754 12090 0 None - 1 Human 6.0 pKi = 6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 514 9 2 3 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1 10.1021/jm970499g
118731115 124949 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 726 16 7 7 2.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2ccccc2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408732 124949 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 726 16 7 7 2.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2ccccc2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
44380107 126878 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 733 14 1 6 8.6 CN(C)CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL350952 126878 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 733 14 1 6 8.6 CN(C)CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
86274487 166868 0 None -933 3 Human 5.0 pKi = 5.0 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)[C@@H]3C)n1 nan
CHEMBL4108583 166868 0 None -933 3 Human 5.0 pKi = 5.0 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)[C@@H]3C)n1 nan
44318455 111454 0 None - 1 Human 7.0 pKi = 7.0 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 510 4 1 4 4.7 N#Cc1cccc(CN2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 10.1016/s0960-894x(02)00488-2
CHEMBL310521 111454 0 None - 1 Human 7.0 pKi = 7.0 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 510 4 1 4 4.7 N#Cc1cccc(CN2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 10.1016/s0960-894x(02)00488-2
44334501 11781 0 None - 1 Human 6.0 pKi = 6.0 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 567 2 0 4 4.4 CC(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL105055 11781 0 None - 1 Human 6.0 pKi = 6.0 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 567 2 0 4 4.4 CC(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
44337207 14602 0 None -10 2 Human 8.0 pKi = 8.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108955 14602 0 None -10 2 Human 8.0 pKi = 8.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44177669 68035 0 None -52 4 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766205 68035 0 None -52 4 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1233 27 9 10 6.3 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
46889691 13699 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 613 6 1 4 7.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084434 13699 0 None -1 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 613 6 1 4 7.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL589082 222577 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None C[C@@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
44611293 97848 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.1 Cc1ccccc1C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397493 97848 0 None - 1 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.1 Cc1ccccc1C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
44337078 113972 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 859 11 0 5 10.5 O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL316552 113972 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 859 11 0 5 10.5 O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL2372070 216956 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None CN(C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1016/s0960-894x(98)00219-4
19610193 114009 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 654 10 1 7 5.3 COc1cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00645-5
CHEMBL316740 114009 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 654 10 1 7 5.3 COc1cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00645-5
44364001 46678 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 717 13 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147767 46678 0 None 1 2 Human 7.0 pKi = 7.0 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 717 13 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314865 211892 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 738 13 0 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77752 211892 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 738 13 0 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281505 123668 0 None -2 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 576 11 1 5 6.9 CO/N=C(\COCc1cc(F)cc(F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33833 123668 0 None -2 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 576 11 1 5 6.9 CO/N=C(\COCc1cc(F)cc(F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281334 126172 0 None -2 2 Human 6.9 pKi = 6.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 541 11 1 6 6.1 CO/N=C(\COCc1ccccn1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL34460 126172 0 None -2 2 Human 6.9 pKi = 6.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 541 11 1 6 6.1 CO/N=C(\COCc1ccccn1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363909 42674 0 None -5 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 739 13 0 7 8.5 CCOC(=O)C1CCCN(C2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
CHEMBL144223 42674 0 None -5 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 739 13 0 7 8.5 CCOC(=O)C1CCCN(C2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
44281587 60332 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 660 11 1 6 7.4 CO/N=C(\CN(C)C(=O)c1ccc(N(C)C)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL160210 60332 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 660 11 1 6 7.4 CO/N=C(\CN(C)C(=O)c1ccc(N(C)C)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
76317390 111386 0 None 5 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 633 6 1 4 7.4 Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104784 111386 0 None 5 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 633 6 1 4 7.4 Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
44408089 146964 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL380449 146964 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 10 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCCN1CCOCC1 10.1016/j.bmcl.2005.10.077
44408051 148005 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 635 7 1 6 5.6 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL382871 148005 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 635 7 1 6 5.6 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(Cc2cc(CN3CCOCC3)on2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44338546 115385 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 382 6 1 3 4.0 Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL320535 115385 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 382 6 1 3 4.0 Fc1cc(COCC(c2ccccc2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
71717930 93137 0 None -39 2 Human 6.9 pKi = 6.9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 448 7 0 6 4.3 CCOC(=O)N(c1ccccc1)C1CCN(CCn2c(=O)n(C3CC3)c3ccccc32)CC1 10.1021/jm301653f
CHEMBL2313631 93137 0 None -39 2 Human 6.9 pKi = 6.9 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 448 7 0 6 4.3 CCOC(=O)N(c1ccccc1)C1CCN(CCn2c(=O)n(C3CC3)c3ccccc32)CC1 10.1021/jm301653f
73350089 96183 0 None 19 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 816 9 8 9 0.5 CCC(C)Cc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
CHEMBL2370510 96183 0 None 19 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 816 9 8 9 0.5 CCC(C)Cc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
73354570 96185 0 None 13 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 814 8 8 9 0.4 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1CC=C(C)C 10.1021/jm00029a007
CHEMBL2370513 96185 0 None 13 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 814 8 8 9 0.4 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1CC=C(C)C 10.1021/jm00029a007
44314866 109682 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 718 13 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)Nc2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306039 109682 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 718 13 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)Nc2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314454 112394 0 None 4 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 758 12 0 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCc3ccccc3C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312295 112394 0 None 4 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 758 12 0 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCc3ccccc3C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
90644614 119486 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288158 119486 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304470 119486 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
90644604 119521 0 None 12 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288153 119521 0 None 12 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305011 119521 0 None 12 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44358589 35792 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 386 9 1 6 2.9 COc1cc(COCC(c2ccccc2)N2CCNCC2)cc(OC)c1OC 10.1016/s0960-894x(02)00956-3
CHEMBL138056 35792 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 386 9 1 6 2.9 COc1cc(COCC(c2ccccc2)N2CCNCC2)cc(OC)c1OC 10.1016/s0960-894x(02)00956-3
9853827 91996 0 None -794 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cellsDisplacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cells
ChEMBL 790 10 6 8 1.5 O=C1C[C@@H](NC(=O)CN2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL225588 91996 0 None -794 3 Human 6.9 pKi = 6.9 Binding
Displacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cellsDisplacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cells
ChEMBL 790 10 6 8 1.5 O=C1C[C@@H](NC(=O)CN2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
9872676 84970 0 None -3162 17 Human 5.9 pKi = 5.9 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 565 11 2 10 4.8 COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 10.1021/jm060012g
CHEMBL210514 84970 0 None -3162 17 Human 5.9 pKi = 5.9 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 565 11 2 10 4.8 COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 10.1021/jm060012g
53472113 125636 0 None -630 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 519 4 0 7 6.3 C[C@@H]1c2nnc(-c3csc(-c4ccc(F)cc4F)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 10.1021/jm5017413
CHEMBL3422009 125636 0 None -630 5 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 519 4 0 7 6.3 C[C@@H]1c2nnc(-c3csc(-c4ccc(F)cc4F)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 10.1021/jm5017413
2132 10516 58 None -1659 6 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
5311424 10516 58 None -1659 6 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
CHEMBL10188 10516 58 None -1659 6 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
71533722 125638 0 None -891 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 10.1021/jm5017413
CHEMBL3422010 125638 0 None -891 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 10.1021/jm5017413
71549769 125646 0 None -3981 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 422 3 0 8 4.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 10.1021/jm5017413
CHEMBL3422018 125646 0 None -3981 5 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 422 3 0 8 4.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 10.1021/jm5017413
10813332 14546 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 447 6 2 2 5.0 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F 10.1021/jm970499g
CHEMBL108933 14546 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 447 6 2 2 5.0 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1F 10.1021/jm970499g
71533722 125638 0 None -891 5 Human 4.9 pKi = 4.9 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 nan
CHEMBL3422010 125638 0 None -891 5 Human 4.9 pKi = 4.9 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 nan
10745123 17315 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 544 10 2 4 4.3 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL1169522 17315 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 544 10 2 4 4.3 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
44337200 16025 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 795 9 2 7 7.2 O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL110766 16025 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 795 9 2 7 7.2 O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
44363984 42442 0 None 4 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 735 14 0 5 9.3 C=CCC1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(00)00702-2
CHEMBL144011 42442 0 None 4 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 735 14 0 5 9.3 C=CCC1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(00)00702-2
44215306 43948 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 725 14 1 6 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CCO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145302 43948 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 725 14 1 6 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CCO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44215303 125740 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 710 12 1 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL342341 125740 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 710 12 1 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363952 127789 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 696 12 1 6 7.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356508 127789 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 696 12 1 6 7.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
118730933 124935 0 None -389 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408519 124935 0 None -389 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
118730933 124935 0 None -389 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3408519 124935 0 None -389 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
56665366 72682 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 792 14 2 5 8.5 O=C(CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
CHEMBL1835843 72682 0 None 10 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 792 14 2 5 8.5 O=C(CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
44177570 68034 0 None -169 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766204 68034 0 None -169 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1219 27 10 10 6.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
44314873 211569 0 None 2 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 12 1 7 6.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL74918 211569 0 None 2 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 12 1 7 6.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10395141 211604 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75367 211604 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44282002 132284 0 None -4 2 Human 7.9 pKi = 7.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 657 13 1 8 6.3 CO/N=C(\CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL36462 132284 0 None -4 2 Human 7.9 pKi = 7.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 657 13 1 8 6.3 CO/N=C(\CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
76317390 111386 0 None 5 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 633 6 1 4 7.4 Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104784 111386 0 None 5 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 633 6 1 4 7.4 Cc1cc(F)ccc1-c1cc(N2CC(F)(F)C[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
10651193 14225 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL108676 14225 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
11273015 65039 0 None -21 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]SP from human cloned NK1 receptorDisplacement of [125I]SP from human cloned NK1 receptor
ChEMBL 563 8 1 3 6.0 CC(=O)NC1(c2ccccc2)CCN(C[C@@H]2C[C@@]2(C(=O)N(C)Cc2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2010.12.135
CHEMBL1682624 65039 0 None -21 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]SP from human cloned NK1 receptorDisplacement of [125I]SP from human cloned NK1 receptor
ChEMBL 563 8 1 3 6.0 CC(=O)NC1(c2ccccc2)CCN(C[C@@H]2C[C@@]2(C(=O)N(C)Cc2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2010.12.135
132837 9018 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
9461 9018 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
CHEMBL22870 9018 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm900473p
132837 9018 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
9461 9018 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
CHEMBL22870 9018 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm800389v
132837 9018 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
132837 9018 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
9461 9018 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
9461 9018 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
CHEMBL22870 9018 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm070332f
CHEMBL22870 9018 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm101023r
2110 9743 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
219077 9743 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
3480 9743 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
CHEMBL346178 9743 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
DB04872 9743 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)Binding Affinity of [3H]- substance P towards Tachykinin receptor 1-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
2110 9743 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
219077 9743 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
3480 9743 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
CHEMBL346178 9743 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
DB04872 9743 38 None -1258 6 Human 5.9 pKi = 5.9 Binding
Binding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 1 (hNK-1) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm980633c
44318665 112927 0 None - 1 Human 6.9 pKi = 6.9 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 531 3 1 4 5.2 CSc1ccc(N2C(=O)NC3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2=O)cc1 10.1016/s0960-894x(02)00488-2
CHEMBL313590 112927 0 None - 1 Human 6.9 pKi = 6.9 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 531 3 1 4 5.2 CSc1ccc(N2C(=O)NC3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2=O)cc1 10.1016/s0960-894x(02)00488-2
132837 9018 55 None 18 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
9461 9018 55 None 18 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
CHEMBL22870 9018 55 None 18 5 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm061369n
132837 9018 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
9461 9018 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
CHEMBL22870 9018 55 None -18 5 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2009.08.035
44337514 12057 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 406 6 1 4 2.8 CN1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL106555 12057 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 406 6 1 4 2.8 CN1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 10.1016/s0960-894x(02)00645-5
15887536 12200 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 646 8 1 4 5.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL107309 12200 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 646 8 1 4 5.9 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccccc2)C1 10.1016/s0960-894x(02)00645-5
54397413 97841 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.0 CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2397486 97841 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.0 CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
44314453 103859 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 758 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CCc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL267333 103859 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 758 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CCc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314732 211873 0 None 3 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 764 12 0 6 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC3CCCCC32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77592 211873 0 None 3 2 Human 6.9 pKi = 6.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 764 12 0 6 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC3CCCCC32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44318694 112803 0 None - 1 Human 6.9 pKi = 6.9 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 575 4 1 3 6.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1cccc(-c3ccccc3)c1)C2=O 10.1016/s0960-894x(02)00488-2
CHEMBL313297 112803 0 None - 1 Human 6.9 pKi = 6.9 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 575 4 1 3 6.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1cccc(-c3ccccc3)c1)C2=O 10.1016/s0960-894x(02)00488-2
44408864 83296 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 451 4 1 1 7.3 CC(C)(C(=O)Nc1ccccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206016 83296 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 451 4 1 1 7.3 CC(C)(C(=O)Nc1ccccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44363990 23084 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 749 14 0 5 9.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC3CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL122643 23084 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 749 14 0 5 9.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC3CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363982 42440 0 None 2 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 683 12 0 6 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144010 42440 0 None 2 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 683 12 0 6 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363442 44714 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 697 12 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145959 44714 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 697 12 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
24768353 104524 0 None -21 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 941 22 9 9 2.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm070332f
CHEMBL271619 104524 0 None -21 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 941 22 9 9 2.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm070332f
44233185 201601 0 None -181 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL539193 201601 0 None -181 4 Rat 7.9 pKi = 7.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1327 29 14 16 1.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
10394952 111526 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 696 12 0 6 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL310703 111526 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 696 12 0 6 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314486 112433 0 None 6 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 739 13 0 7 6.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(N(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312528 112433 0 None 6 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 739 13 0 7 6.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(N(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
9987474 211612 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75436 211612 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44177670 68036 0 None -190 4 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766206 68036 0 None -190 4 Rat 6.9 pKi = 6.9 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1151 27 10 10 5.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cccc(C(F)(F)F)c1 10.1021/jm101023r
44281345 117257 0 None -10 2 Human 6.9 pKi = 6.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1cccc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32477 117257 0 None -10 2 Human 6.9 pKi = 6.9 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1cccc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44337353 12199 0 None -9 2 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL107306 12199 0 None -9 2 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL388265 219194 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O 10.1021/jm901352b
44318677 212473 0 None - 1 Human 5.8 pKi = 5.8 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 531 3 0 3 4.9 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3ccccc3F)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL82278 212473 0 None - 1 Human 5.8 pKi = 5.8 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 531 3 0 3 4.9 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3ccccc3F)CC2)C1=O 10.1016/s0960-894x(02)00488-2
44337080 117375 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 945 11 2 7 8.8 CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccc(Cl)c(Cl)c2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00645-5
CHEMBL325547 117375 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 945 11 2 7 8.8 CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccc(Cl)c(Cl)c2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00645-5
44380313 64865 0 None 15 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 647 10 1 4 8.3 O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167409 64865 0 None 15 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 647 10 1 4 8.3 O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44380095 127634 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 687 11 1 6 8.6 N#CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355868 127634 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 687 11 1 6 8.6 N#CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44337174 14655 0 None -11 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 5.8 CC(=O)Nc1ccc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/s0960-894x(02)00645-5
CHEMBL108997 14655 0 None -11 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 5.8 CC(=O)Nc1ccc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/s0960-894x(02)00645-5
9566253 82285 1 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 414 4 1 5 6.1 Cc1onc(-c2c(Cl)cccc2Cl)c1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL204327 82285 1 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 414 4 1 5 6.1 Cc1onc(-c2c(Cl)cccc2Cl)c1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL3609617 218610 0 None -501 4 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
73212437 111388 0 None 630 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 559 8 1 4 4.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 10.1016/j.bmcl.2013.12.033
CHEMBL3104786 111388 0 None 630 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 559 8 1 4 4.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 10.1016/j.bmcl.2013.12.033
90644632 118723 0 None 7 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 698 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288168 118723 0 None 7 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 698 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
90644628 119511 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.4 CNCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
CHEMBL3288165 119511 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.4 CNCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
CHEMBL3304854 119511 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.4 CNCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
10141196 33573 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 8 1 4 4.7 O=C(O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL136291 33573 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 490 8 1 4 4.7 O=C(O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
135530616 36565 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 529 8 2 6 4.6 Oc1n[nH]c(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)CC2)n1 10.1016/s0960-894x(02)00956-3
CHEMBL138716 36565 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 529 8 2 6 4.6 Oc1n[nH]c(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)CC2)n1 10.1016/s0960-894x(02)00956-3
10230370 37367 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 534 11 1 5 4.7 O=C(O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139382 37367 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 534 11 1 5 4.7 O=C(O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358408 37744 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 9 0 5 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCN3CCOCC3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL139859 37744 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 545 9 0 5 4.9 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCN3CCOCC3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44358597 38234 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1ccc(COCC(c2ccccc2)N2CCNCC2)c(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL140302 38234 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 432 6 1 3 4.9 FC(F)(F)c1ccc(COCC(c2ccccc2)N2CCNCC2)c(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
9852911 106159 0 None 8 6 Human 6.8 pKi = 6.8 Binding
Binding affinity against Tachykinin receptor 1Binding affinity against Tachykinin receptor 1
ChEMBL 678 20 2 7 7.4 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm0205088
CHEMBL282618 106159 0 None 8 6 Human 6.8 pKi = 6.8 Binding
Binding affinity against Tachykinin receptor 1Binding affinity against Tachykinin receptor 1
ChEMBL 678 20 2 7 7.4 NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1OCc1ccccc1 10.1021/jm0205088
10085946 172119 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 296 7 2 3 3.3 CNC(c1ccccc1)C1(NCc2ccccc2OC)CC1 10.1016/s0960-894x(01)00020-8
CHEMBL423597 172119 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 296 7 2 3 3.3 CNC(c1ccccc1)C1(NCc2ccccc2OC)CC1 10.1016/s0960-894x(01)00020-8
25222441 203920 0 None -30 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 589 8 0 3 6.4 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccc(F)c(C(F)(F)F)c2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
CHEMBL567849 203920 0 None -30 4 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 589 8 0 3 6.4 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccc(F)c(C(F)(F)F)c2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
118730936 124938 0 None -16982 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 684 14 7 7 1.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408522 124938 0 None -16982 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 684 14 7 7 1.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
10552479 115780 0 None - 1 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 474 7 2 4 4.8 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL321215 115780 0 None - 1 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 474 7 2 4 4.8 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
44315267 112282 0 None -63 3 Human 6.8 pKi = 6.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 701 11 1 7 8.5 CO/N=C(\CN(C(=O)c1cc(Cl)cc(Cl)c1)C1CC1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL312141 112282 0 None -63 3 Human 6.8 pKi = 6.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 701 11 1 7 8.5 CO/N=C(\CN(C(=O)c1cc(Cl)cc(Cl)c1)C1CC1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44358421 36525 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 422 6 1 4 4.5 FC(F)(F)c1cc(COCC(c2ccco2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL138682 36525 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 422 6 1 4 4.5 FC(F)(F)c1cc(COCC(c2ccco2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44363962 42704 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 753 14 0 7 8.7 CCOC(=O)C1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
CHEMBL144249 42704 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 753 14 0 7 8.7 CCOC(=O)C1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
44363949 127720 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 683 11 0 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356105 127720 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 683 11 0 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314502 211576 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 712 12 1 7 5.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75018 211576 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 712 12 1 7 5.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10531434 14231 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 587 9 3 3 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL108683 14231 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 587 9 3 3 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
51351504 67383 1 None -4 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n(C)n2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760206 67383 1 None -4 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n(C)n2)CC1 10.1016/j.bmcl.2011.02.033
118731119 124953 0 None -162181 2 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 686 17 7 7 1.5 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1ccccc1 10.1016/j.ejmech.2014.12.033
CHEMBL3408736 124953 0 None -162181 2 Human 4.8 pKi = 4.8 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 686 17 7 7 1.5 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1ccccc1 10.1016/j.ejmech.2014.12.033
44351946 124147 1 None -1778 3 Human 5.8 pKi = 5.8 Binding
Inhibition of binding of [3H]SP to human Tachykinin receptor 1 expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to human Tachykinin receptor 1 expressed in mouse erythroleukemia cells
ChEMBL 568 8 0 3 7.3 CCN1C(=O)c2ccccc2[C@H]1[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
CHEMBL339767 124147 1 None -1778 3 Human 5.8 pKi = 5.8 Binding
Inhibition of binding of [3H]SP to human Tachykinin receptor 1 expressed in mouse erythroleukemia cellsInhibition of binding of [3H]SP to human Tachykinin receptor 1 expressed in mouse erythroleukemia cells
ChEMBL 568 8 0 3 7.3 CCN1C(=O)c2ccccc2[C@H]1[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
44281784 120270 0 None -6 2 Human 6.8 pKi = 6.8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 10 1 6 8.3 CO/N=C(\COC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33198 120270 0 None -6 2 Human 6.8 pKi = 6.8 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 10 1 6 8.3 CO/N=C(\COC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44318865 212919 0 None - 1 Human 5.8 pKi = 5.8 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 671 7 0 7 3.8 COc1ccc(N2CN(CC(=O)N3CCC4(CC3)C(=O)N(C)C(=O)N4Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2=O)cc1OC 10.1016/s0960-894x(02)00488-2
CHEMBL86053 212919 0 None - 1 Human 5.8 pKi = 5.8 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 671 7 0 7 3.8 COc1ccc(N2CN(CC(=O)N3CCC4(CC3)C(=O)N(C)C(=O)N4Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2=O)cc1OC 10.1016/s0960-894x(02)00488-2
44380094 65518 0 None 3 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 719 13 2 6 7.6 NC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168584 65518 0 None 3 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 719 13 2 6 7.6 NC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
141952732 127243 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
44380527 127243 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
CHEMBL354091 127243 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
44337467 116992 0 None 17 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 821 13 2 7 7.8 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL323741 116992 0 None 17 2 Human 7.8 pKi = 7.8 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 821 13 2 7 7.8 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
44363936 26807 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 782 14 1 7 9.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL130354 26807 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 782 14 1 7 9.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
9868422 177058 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 451 4 0 1 7.0 Cc1ccccc1-c1ccccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL444624 177058 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 451 4 0 1 7.0 Cc1ccccc1-c1ccccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
10507771 116515 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1cccc2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL322975 116515 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1cccc2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
73353537 97845 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.3 C[C@@H](c1ccccc1)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397490 97845 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.3 C[C@@H](c1ccccc1)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
10790280 115396 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 463 6 2 2 5.1 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL320583 115396 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 463 6 2 2 5.1 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
10649307 117145 0 None - 1 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 507 6 2 2 5.2 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Br 10.1021/jm970499g
CHEMBL324177 117145 0 None - 1 Human 5.8 pKi = 5.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 507 6 2 2 5.2 O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CCCN1C(=S)NCc1ccccc1Br 10.1021/jm970499g
10531273 15971 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 9 3 4 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(=O)O 10.1021/jm970499g
CHEMBL110393 15971 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 578 9 3 4 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(=O)O 10.1021/jm970499g
71549913 125634 0 None -1737 3 Human 4.8 pKi = 4.8 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 415 3 0 6 4.6 Cc1cccc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
CHEMBL3422007 125634 0 None -1737 3 Human 4.8 pKi = 4.8 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 415 3 0 6 4.6 Cc1cccc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
44408725 172847 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 375 4 1 3 6.2 Clc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL425768 172847 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 375 4 1 3 6.2 Clc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
7088456 206306 1 None - 1 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL592133 206306 1 None - 1 Rat 6.8 pKi = 6.8 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 10.1021/jm901352b
44363908 42557 0 None -4 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 11 0 5 8.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144116 42557 0 None -4 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 11 0 5 8.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363756 46611 0 None 8 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 703 12 1 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147715 46611 0 None 8 2 Human 7.8 pKi = 7.8 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 703 12 1 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44138558 199817 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL522292 199817 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 3 1 2 5.4 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
10189341 16891 0 None 10 2 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL115633 16891 0 None 10 2 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
10746177 13795 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 602 8 2 3 6.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(F)(F)F 10.1021/jm970499g
CHEMBL108481 13795 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 602 8 2 3 6.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1C(F)(F)F 10.1021/jm970499g
11100291 184456 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 353 8 3 3 0.9 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
CHEMBL464178 184456 0 None - 1 Rat 7.7 pKi = 7.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 353 8 3 3 0.9 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
10649931 14647 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 531 9 3 3 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL108990 14647 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 531 9 3 3 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=N)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL2371916 216931 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O 10.1021/jm00391a046
20906619 67442 7 None -7 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 396 4 1 4 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760338 67442 7 None -7 4 Human 5.8 pKi = 5.8 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 396 4 1 4 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
73353047 96181 0 None 1 2 Human 4.8 pKi = 4.8 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 746 6 8 9 -1.1 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
CHEMBL2370509 96181 0 None 1 2 Human 4.8 pKi = 4.8 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 746 6 8 9 -1.1 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
44314547 109652 0 None 5 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 661 11 0 5 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL305826 109652 0 None 5 2 Human 6.7 pKi = 6.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 661 11 0 5 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
25221995 203630 0 None -67 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 601 8 0 3 6.5 CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm900948q
CHEMBL565894 203630 0 None -67 4 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 601 8 0 3 6.5 CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm900948q
46228976 205923 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 297 6 3 3 0.9 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)c1ccccc1 10.1021/jm901352b
CHEMBL589329 205923 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 297 6 3 3 0.9 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)c1ccccc1 10.1021/jm901352b
15487997 97837 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 8 3 3 1.0 CN[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397482 97837 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 8 3 3 1.0 CN[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
44363925 46837 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 754 13 1 7 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147924 46837 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 754 13 1 7 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314871 112470 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 712 12 0 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312573 112470 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 712 12 0 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
90644630 118721 0 None 50 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 725 13 2 6 6.2 CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
CHEMBL3288166 118721 0 None 50 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 725 13 2 6 6.2 CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
90644620 119568 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288161 119568 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305870 119568 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44407901 147222 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 701 10 1 6 6.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL380928 147222 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 701 10 1 6 6.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44358409 126120 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 6 1 3 4.7 NC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL344265 126120 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 6 1 3 4.7 NC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
46224928 206181 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 515 2 1 2 6.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591074 206181 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 515 2 1 2 6.2 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCC=CC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
54583959 67443 0 None -3 4 Human 5.7 pKi = 5.7 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 410 5 1 4 3.7 COc1ccccc1CN1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760339 67443 0 None -3 4 Human 5.7 pKi = 5.7 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 410 5 1 4 3.7 COc1ccccc1CN1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
90644606 119567 0 None 6 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288154 119567 0 None 6 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305869 119567 0 None 6 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 2 6 5.3 CN1C(=O)OC2(CCN(CC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44338530 16129 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 332 6 1 3 3.1 Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL111303 16129 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 332 6 1 3 3.1 Fc1cc(F)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
11239751 91946 0 None -1995 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cellsDisplacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cells
ChEMBL 785 10 7 8 -0.5 NS(=O)(=O)N1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL225297 91946 0 None -1995 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cellsDisplacement of [3H][Sar9]SP sulfone from human NK1 receptor expressed in U373MG cells
ChEMBL 785 10 7 8 -0.5 NS(=O)(=O)N1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
44322610 213424 0 None - 1 Human 6.7 pKi = 6.7 Binding
Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1
ChEMBL 462 5 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1021/jm058225d
CHEMBL89245 213424 0 None - 1 Human 6.7 pKi = 6.7 Binding
Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1
ChEMBL 462 5 1 2 5.6 O=C(CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(c1ccc(F)cc1)C1CCNCC1 10.1021/jm058225d
86274490 166665 0 None -1000 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1 nan
CHEMBL4106866 166665 0 None -1000 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1 nan
44315210 109695 0 None 1 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 14 0 8 8.0 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306124 109695 0 None 1 3 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 14 0 8 8.0 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44409023 146996 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL380510 146996 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 578 5 0 4 6.8 Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44560754 179976 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 445 5 1 2 5.9 C[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
CHEMBL452269 179976 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 445 5 1 2 5.9 C[C@@H]1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2008.05.082
10359664 120779 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SPIn vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SP
ChEMBL 336 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 10.1021/jm00051a001
CHEMBL332644 120779 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SPIn vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]BH-SP
ChEMBL 336 3 2 3 4.0 COc1ccccc1[C@@H]1CC[C@@]2(CCCN[C@H]2c2ccccc2)NC1 10.1021/jm00051a001
9896563 110557 0 None 5 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL308891 110557 0 None 5 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
9810288 210470 0 None 8 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67508 210470 0 None 8 2 Guinea pig 8.7 pKi = 8.7 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44281633 106763 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 664 11 1 7 7.7 CO/N=C(\CN(C)C(=O)c1cc(C)nc(-c2cccs2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286646 106763 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 664 11 1 7 7.7 CO/N=C(\CN(C)C(=O)c1cc(C)nc(-c2cccs2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281649 115797 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 625 11 1 7 6.0 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32124 115797 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 625 11 1 7 6.0 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281666 115982 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 635 10 1 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32163 115982 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 635 10 1 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281650 120574 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 651 11 1 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N2CCCC2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33243 120574 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 651 11 1 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N2CCCC2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10394882 120589 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 689 10 2 5 7.9 CO/N=C(\CNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33249 120589 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 689 10 2 5 7.9 CO/N=C(\CNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
52943090 24933 0 None 79 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 666 5 0 4 4.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
CHEMBL1269640 24933 0 None 79 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cellDisplacement of [3H]substance P from human neurokinin NK1 receptor expressed in CHO cell
ChEMBL 666 5 0 4 4.8 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@@H]1c1ccc(F)cc1 10.1016/j.bmcl.2010.08.138
71453994 90309 0 None 10 2 Human 8.7 pKi = 8.7 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 583 5 1 4 6.7 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203706 90309 0 None 10 2 Human 8.7 pKi = 8.7 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 583 5 1 4 6.7 Cc1cc(F)ccc1-c1cc(N2CC[C@H](O)C2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
44380413 103371 0 None 21 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 741 15 1 7 6.2 COCCNC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL263214 103371 0 None 21 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 741 15 1 7 6.2 COCCNC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44380249 127122 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 12 1 6 7.3 CN(C/C(=N\OCc1c[nH]cn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL353027 127122 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 12 1 6 7.3 CN(C/C(=N\OCc1c[nH]cn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
127034831 143291 0 None -2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity at human NK1R assessed as inhibition constantBinding affinity at human NK1R assessed as inhibition constant
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(C)C(=O)NCC(=O)N(C)C(Cc1ccccc1)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c01456
CHEMBL3736287 143291 0 None -2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity at human NK1R assessed as inhibition constantBinding affinity at human NK1R assessed as inhibition constant
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(C)C(=O)NCC(=O)N(C)C(Cc1ccccc1)C(=O)N1CCCC1C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c01456
72734611 97759 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
CHEMBL2396664 97759 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
72734611 97759 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
CHEMBL2396664 97759 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/ml5002954
127032846 145569 0 None 4 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1081 24 9 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
CHEMBL3780818 145569 0 None 4 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting methodDisplacement of [3H]SP from human NK1 receptor transfected in CHO cells by liquid scintillation counting method
ChEMBL 1081 24 9 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
145948744 174254 0 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299371 174254 0 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
72734611 97759 0 None -1 2 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2018.06.009
CHEMBL2396664 97759 0 None -1 2 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1016/j.bmcl.2018.06.009
72734611 97759 0 None -1 2 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2396664 97759 0 None -1 2 Rat 8.7 pKi = 8.7 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@@H]1[C@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
10769060 12806 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 10.1021/jm970499g
CHEMBL108040 12806 0 None - 1 Human 8.7 pKi = 8.7 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccc(F)cc1 10.1021/jm970499g
11353915 13725 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 601 9 1 4 7.6 CCCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1084525 13725 0 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 601 9 1 4 7.6 CCCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
46889692 13700 0 None 12 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 613 6 1 4 7.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084435 13700 0 None 12 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 613 6 1 4 7.7 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CCCC[C@@H]2CO)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44315209 211690 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 728 12 0 8 7.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC#N)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76093 211690 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 728 12 0 8 7.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC#N)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44178113 68038 0 None -12 3 Rat 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
CHEMBL1766208 68038 0 None -12 3 Rat 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1237 27 10 11 5.6 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm101023r
10793340 12497 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc([N+](=O)[O-])c1 10.1021/jm970499g
CHEMBL107830 12497 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 579 9 2 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc([N+](=O)[O-])c1 10.1021/jm970499g
10817098 117305 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL325106 117305 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1Cl 10.1021/jm970499g
44380090 127498 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 13 0 6 7.0 COCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354771 127498 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 684 13 0 6 7.0 COCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44315422 109916 0 None 2 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 13 1 8 7.5 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307877 109916 0 None 2 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 747 13 1 8 7.5 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44315591 211753 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 746 13 1 8 6.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(N)=O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76529 211753 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 746 13 1 8 6.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(N)=O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44315299 211790 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 737 12 0 6 8.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccsc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76823 211790 0 None -1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 737 12 0 6 8.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccsc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9940831 21418 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1205204 21418 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL65468 21418 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.Binding affinity for NK-1 receptor was determined in a radioligand binding assay using IM9 human lymphoblastoma cell line.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
10237920 86617 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 416 5 0 2 6.1 C[C@@H](OCC1(c2ccccc2)CC(=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL212173 86617 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 416 5 0 2 6.1 C[C@@H](OCC1(c2ccccc2)CC(=O)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
9927183 202384 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1016/S0960-894X(01)80386-3
CHEMBL55591 202384 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonistIn vitro binding affinity towards human NK-1 receptor in IM-9 cells using [3H]SP of substance P antagonist
ChEMBL 322 5 2 3 3.7 COc1ccccc1CN[C@@H]1[C@H](c2ccccc2)N[C@H]2CCC[C@H]21 10.1016/S0960-894X(01)80386-3
44315572 109758 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 689 11 1 7 8.3 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306624 109758 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 689 11 1 7 8.3 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
145948965 174267 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1183 22 9 9 6.1 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299476 174267 0 None 1 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1183 22 9 9 6.1 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
11794060 125976 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 7 2.5 COc1ccc(-c2nnn(C)n2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
CHEMBL343219 125976 0 None - 1 Human 8.6 pKi = 8.6 Binding
Binding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cellsBinding affinity to Tachykinin receptor 1 stably expressed in chinese hamster ovary (CHO) cells
ChEMBL 378 6 2 7 2.5 COc1ccc(-c2nnn(C)n2)cc1CN[C@H]1CCCN[C@H]1c1ccccc1 10.1021/jm00026a005
86302473 119525 0 None 3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 11 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288169 119525 0 None 3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 11 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305156 119525 0 None 3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 11 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44408040 81194 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 637 7 1 6 5.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL202627 81194 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 637 7 1 6 5.1 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
9874480 81548 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 661 9 3 4 6.1 COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL203113 81548 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 661 9 3 4 6.1 COc1ccccc1CNCCNC(=O)N1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44407908 147335 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 687 9 1 7 4.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 10.1016/j.bmcl.2005.10.077
CHEMBL381155 147335 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 687 9 1 7 4.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCS(=O)(=O)CC1 10.1016/j.bmcl.2005.10.077
44358317 123315 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 488 9 0 3 6.4 CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL336251 123315 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 488 9 0 3 6.4 CCCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358425 172225 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 548 11 1 5 5.3 C[C@H](OC[C@@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL423913 172225 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 548 11 1 5 5.3 C[C@H](OC[C@@H](c1ccccc1)N1CCN(CCOCC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
145948839 174258 0 None -6 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1137 22 8 9 5.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299415 174258 0 None -6 4 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1137 22 8 9 5.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44560774 179749 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 4.1 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
CHEMBL451764 179749 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 524 7 2 4 4.1 C[C@@H](OC[C@@]1(c2ccccc2)C[C@@H](NS(C)(=O)=O)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2008.05.082
73348949 97597 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 minsDisplacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 mins
ChEMBL 494 5 1 2 6.0 Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2013.01.025
CHEMBL2392023 97597 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 minsDisplacement of [3H]Substance P from human recombinant substance P receptor expressed in CHO cells after 90 mins
ChEMBL 494 5 1 2 6.0 Ic1ccccc1N[C@@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2013.01.025
10816496 11975 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 550 8 3 4 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1O 10.1021/jm970499g
CHEMBL106100 11975 0 None - 1 Human 8.6 pKi = 8.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 550 8 3 4 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1O 10.1021/jm970499g
46889669 13783 0 None 2 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 585 5 1 4 7.0 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@@H](O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
CHEMBL1084771 13783 0 None 2 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 585 5 1 4 7.0 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cnc(N2CC[C@@H](O)C2)cc1-c1ccccc1Cl 10.1016/j.bmcl.2010.04.008
44315231 112176 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 780 13 0 8 8.8 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(Cc3ccccn3)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL311712 112176 0 None 1 3 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 780 13 0 8 8.8 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(Cc3ccccn3)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44408062 147334 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
CHEMBL381151 147334 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
10600310 93134 0 None 13 2 Human 8.6 pKi = 8.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 466 7 0 5 4.9 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cccc(Cl)c3)CC2)c2ccccc21 10.1021/jm301653f
CHEMBL2313628 93134 0 None 13 2 Human 8.6 pKi = 8.6 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 466 7 0 5 4.9 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cccc(Cl)c3)CC2)c2ccccc21 10.1021/jm301653f
44380248 64937 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 13 0 7 7.3 CN(C/C(=N\OCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168144 64937 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 13 0 7 7.3 CN(C/C(=N\OCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
71457524 90308 0 None -5 2 Human 8.6 pKi = 8.6 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL2203705 90308 0 None -5 2 Human 8.6 pKi = 8.6 Binding
Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cellsDisplacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells
ChEMBL 597 6 1 4 7.1 Cc1cc(F)ccc1-c1cc(N2CCC[C@H]2CO)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm2017072
CHEMBL3609619 218612 0 None 34 3 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
145948981 174270 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1139 22 9 9 6.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299483 174270 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1139 22 9 9 6.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
9874473 48582 0 None 16 3 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 48582 0 None 16 3 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
44380732 65766 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 13 2 6 8.1 OCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL169002 65766 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 13 2 6 8.1 OCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44363436 42489 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 12 0 5 9.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144057 42489 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 12 0 5 9.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363979 127761 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 13 1 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356268 127761 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 13 1 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10484667 211334 0 None -2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL72930 211334 0 None -2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL2370435 216628 0 None -48 2 Guinea pig 7.7 pKi = 7.7 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O 10.1021/jm00073a022
44314578 211927 0 None 13 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 14 1 7 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NCC2CCCO2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78091 211927 0 None 13 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 14 1 7 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NCC2CCCO2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL5271987 200483 0 None - 1 Human 6.7 pKi = 6.7 Binding
Inhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cellsInhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cells
ChEMBL 761 12 5 7 6.2 CC(C)C[C@H](NC(=O)CNC(=O)OCc1ccccc1)C(=O)NC1(C(=O)OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CNc2[nH]c3ccccc3c2C1 10.1021/acs.jmedchem.6b01029
13821356 113497 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL 995 25 10 16 0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1ccc(Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)C(N)=O 10.1021/jm00391a046
CHEMBL3144091 113497 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL 995 25 10 16 0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1ccc(Nc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1)C(N)=O 10.1021/jm00391a046
44318578 212471 0 None - 1 Human 5.7 pKi = 5.7 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 521 8 1 3 5.6 CCCCCCCCN1C(=O)NC2(CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL82274 212471 0 None - 1 Human 5.7 pKi = 5.7 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 521 8 1 3 5.6 CCCCCCCCN1C(=O)NC2(CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)C1=O 10.1016/s0960-894x(02)00488-2
2110 9743 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
219077 9743 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
3480 9743 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
CHEMBL346178 9743 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
DB04872 9743 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
2110 9743 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
219077 9743 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
3480 9743 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
CHEMBL346178 9743 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
DB04872 9743 38 None -1258 6 Human 6.7 pKi = 6.7 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm2017072
44337330 12104 0 None -6 2 Human 7.7 pKi = 7.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106816 12104 0 None -6 2 Human 7.7 pKi = 7.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
86275688 155086 0 None -794 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)C3C)n1 nan
CHEMBL3936869 155086 0 None -794 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)C3C)n1 nan
18393120 12032 0 None -10 2 Human 6.7 pKi = 6.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 502 5 2 4 4.0 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCNCC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106404 12032 0 None -10 2 Human 6.7 pKi = 6.7 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 502 5 2 4 4.0 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCNCC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44408736 147664 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 471 4 0 1 7.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL382043 147664 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 471 4 0 1 7.3 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Cl 10.1016/j.bmcl.2005.11.047
44314503 211772 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 698 12 1 7 5.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL76704 211772 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 698 12 1 7 5.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL5083565 221650 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]SP from human NK1R expressed in U373 MG cells assessed as inhibitory constant incubated for 30 mins by radioligand binding assayDisplacement of [125I]SP from human NK1R expressed in U373 MG cells assessed as inhibitory constant incubated for 30 mins by radioligand binding assay
ChEMBL None None None C[C@@H](O[C@H]1O[C@@H]2CC[C@@H](c3ccccc3)O[C@@H]2[C@H](O)[C@H]1OCc1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.1c00793
10839138 93135 0 None -11 2 Human 6.7 pKi = 6.7 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 500 7 0 5 5.5 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cc(Cl)ccc3Cl)CC2)c2ccccc21 10.1021/jm301653f
CHEMBL2313629 93135 0 None -11 2 Human 6.7 pKi = 6.7 Binding
Antagonist activity at NK1 receptor (unknown origin)Antagonist activity at NK1 receptor (unknown origin)
ChEMBL 500 7 0 5 5.5 C=C(C)n1c(=O)n(CCN2CCC(N(C(=O)CC)c3cc(Cl)ccc3Cl)CC2)c2ccccc21 10.1021/jm301653f
51351496 67382 7 None -4 4 Human 5.7 pKi = 5.7 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)nn2C)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760205 67382 7 None -4 4 Human 5.7 pKi = 5.7 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)nn2C)CC1 10.1016/j.bmcl.2011.02.033
86274732 129773 0 None -691 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 388 4 1 8 1.8 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3CCO)n1 nan
CHEMBL3608741 129773 0 None -691 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 388 4 1 8 1.8 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3CCO)n1 nan
86274727 167562 0 None -912 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1 nan
CHEMBL4114280 167562 0 None -912 3 Human 4.7 pKi = 4.7 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1 nan
18546500 83482 1 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 410 5 0 1 7.1 FC(F)(F)c1cc(COCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206490 83482 1 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 410 5 0 1 7.1 FC(F)(F)c1cc(COCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
46228975 208411 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 297 6 3 3 0.9 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)c1ccccc1 10.1021/jm901352b
CHEMBL605906 208411 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 297 6 3 3 0.9 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)c1ccccc1 10.1021/jm901352b
44334665 174776 0 None - 1 Human 5.6 pKi = 5.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 583 6 1 5 4.0 O=C1C2CN(C(=O)COCc3ccccc3)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL432007 174776 0 None - 1 Human 5.6 pKi = 5.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 583 6 1 5 4.0 O=C1C2CN(C(=O)COCc3ccccc3)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
44337308 12218 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 600 7 1 4 5.6 O=C(c1cc(F)cc(F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL107407 12218 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 600 7 1 4 5.6 O=C(c1cc(F)cc(F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL2372065 216954 0 None - 1 Human 7.6 pKi = 7.6 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None CN(C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)N1C2CC3CCC2(CS1(=O)=O)C3(C)C)[C@@H](Cc1ccc(Cc2ccccc2)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1016/s0960-894x(98)00219-4
44233184 201547 0 None -12 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL538131 201547 0 None -12 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1343 32 15 16 1.7 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
44314504 109693 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 682 12 0 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306121 109693 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 682 12 0 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281357 118510 0 None - 1 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 660 10 1 4 9.1 CO/N=C(\CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32872 118510 0 None - 1 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 660 10 1 4 9.1 CO/N=C(\CCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL3609618 218611 0 None -1148 4 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
44334664 11312 0 None - 1 Human 5.6 pKi = 5.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 625 6 0 5 4.3 CC(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)COCc1ccccc1 10.1016/s0960-894x(02)00659-5
CHEMBL102356 11312 0 None - 1 Human 5.6 pKi = 5.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 625 6 0 5 4.3 CC(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)COCc1ccccc1 10.1016/s0960-894x(02)00659-5
86274488 167496 0 None -1584 2 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 372 3 0 7 2.7 CCc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3C)n1 nan
CHEMBL4113741 167496 0 None -1584 2 Human 4.6 pKi = 4.6 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 372 3 0 7 2.7 CCc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3C)n1 nan
44380093 127514 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 733 13 2 6 7.8 CNC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354892 127514 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 733 13 2 6 7.8 CNC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10010039 46679 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 14 2 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC2(CO)CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147769 46679 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 14 2 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC2(CO)CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44305793 107622 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL293432 107622 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314577 166659 0 None 16 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 782 14 0 8 7.1 CCOC(=O)C1CCN(C(=O)CN2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/s0960-894x(00)00464-9
CHEMBL41068 166659 0 None 16 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 782 14 0 8 7.1 CCOC(=O)C1CCN(C(=O)CN2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/s0960-894x(00)00464-9
44314299 211924 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 739 13 1 7 5.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78070 211924 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 739 13 1 7 5.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44318269 212769 0 None - 1 Human 6.6 pKi = 6.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 543 3 1 5 4.2 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1ccc3c(c1)OCO3)C2=O 10.1016/s0960-894x(02)00488-2
CHEMBL84761 212769 0 None - 1 Human 6.6 pKi = 6.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 543 3 1 5 4.2 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(Cc1ccc3c(c1)OCO3)C2=O 10.1016/s0960-894x(02)00488-2
44380474 65557 0 None 13 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 678 12 2 5 8.2 CONC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168769 65557 0 None 13 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 678 12 2 5 8.2 CONC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10417108 106876 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL287454 106876 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44314482 110586 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL309087 110586 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44380795 212911 0 None 7 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 1 7 8.3 COC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL85980 212911 0 None 7 2 Human 7.6 pKi = 7.6 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 734 13 1 7 8.3 COC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44337313 115380 0 None -7 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320487 115380 0 None -7 2 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44314482 110586 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL309087 110586 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363963 128055 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 724 13 1 6 7.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL357853 128055 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 724 13 1 6 7.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10417108 106876 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL287454 106876 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314482 110586 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL309087 110586 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314482 110586 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL309087 110586 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10417108 106876 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity of compound against Tachykinin receptor 1Tested for binding affinity of compound against Tachykinin receptor 1
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL287454 106876 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity of compound against Tachykinin receptor 1Tested for binding affinity of compound against Tachykinin receptor 1
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44338532 14402 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 324 6 1 3 3.5 Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL108822 14402 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 324 6 1 3 3.5 Cc1cc(C)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
9801487 213777 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1021/jm058225d
CHEMBL91418 213777 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1Negative logarithm causing 50% receptor occupancy against tachykinin receptor 1
ChEMBL 406 5 1 3 4.8 Cc1cc(C)cc(OCC(=O)N(c2ccc(Cl)c(Cl)c2)C2CCNCC2)c1 10.1021/jm058225d
10603383 118124 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1c(Cl)cccc1Cl 10.1021/jm970499g
CHEMBL326893 118124 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1c(Cl)cccc1Cl 10.1021/jm970499g
73345476 96186 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 800 9 7 8 1.0 CCC(C)Cc1cc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
CHEMBL2370514 96186 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 800 9 7 8 1.0 CCC(C)Cc1cc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
45379601 207520 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 317 7 3 4 0.8 NC(=O)[C@H](Cc1cccs1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL600224 207520 0 None - 1 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 317 7 3 4 0.8 NC(=O)[C@H](Cc1cccs1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
73212518 111377 0 None 39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 489 8 3 3 4.2 CNCCNC(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2013.12.033
CHEMBL3104774 111377 0 None 39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 489 8 3 3 4.2 CNCCNC(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2013.12.033
73212440 111382 0 None 39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 558 8 2 4 4.2 CN1CCN(CCNC(=O)[C@@H](NC(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/j.bmcl.2013.12.033
CHEMBL3104780 111382 0 None 39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 558 8 2 4 4.2 CN1CCN(CCNC(=O)[C@@H](NC(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/j.bmcl.2013.12.033
90644624 119538 0 None -6 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 3 6 5.3 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288163 119538 0 None -6 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 3 6 5.3 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305323 119538 0 None -6 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 3 6 5.3 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44358385 34236 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 702 13 0 6 8.4 COc1cc(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)C(Cc3ccccc3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00956-3
CHEMBL136850 34236 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 702 13 0 6 8.4 COc1cc(CN2CCN(C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c3ccccc3)C(Cc3ccccc3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00956-3
73212593 111379 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 502 5 1 3 4.7 CC(C)(C(=O)N[C@@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104776 111379 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 502 5 1 3 4.7 CC(C)(C(=O)N[C@@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
73212592 111383 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 545 8 2 4 4.3 CC(C)(C(=O)N[C@@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104781 111383 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 545 8 2 4 4.3 CC(C)(C(=O)N[C@@H](C(=O)NCCN1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
145948981 174270 0 None -9 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1139 22 9 9 6.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299483 174270 0 None -9 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1139 22 9 9 6.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
73353535 97840 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.2 C[C@@](Cc1ccccc1)(NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397485 97840 0 None - 1 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.2 C[C@@](Cc1ccccc1)(NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
44281778 116473 0 None -4 2 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32279 116473 0 None -4 2 Human 7.6 pKi = 7.6 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10794699 16009 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 684 9 2 3 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL110688 16009 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 684 9 2 3 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
10530592 17316 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 544 10 2 4 4.3 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL1169523 17316 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 544 10 2 4 4.3 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
44334591 114198 0 None - 1 Human 6.6 pKi = 6.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 667 4 0 5 4.9 CS(=O)(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)c1ccc2ccccc2c1 10.1016/s0960-894x(02)00659-5
CHEMBL318093 114198 0 None - 1 Human 6.6 pKi = 6.6 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 667 4 0 5 4.9 CS(=O)(=O)N1CCC2(CC1)C1C(=O)N(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)C1CN2C(=O)c1ccc2ccccc2c1 10.1016/s0960-894x(02)00659-5
10627789 107354 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against Tachykinin receptor 1Binding affinity against Tachykinin receptor 1
ChEMBL 630 18 3 7 5.3 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O 10.1021/jm0205088
CHEMBL29161 107354 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity against Tachykinin receptor 1Binding affinity against Tachykinin receptor 1
ChEMBL 630 18 3 7 5.3 CC(=O)NCCCCCOC[C@H]1O[C@@H](OCCc2c[nH]c3ccccc23)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@@H]1O 10.1021/jm0205088
52937271 69295 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL1782139 69295 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
52937271 69295 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782139 69295 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 515 5 1 3 3.8 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
145948797 174255 0 None -26 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1105 22 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299390 174255 0 None -26 4 Rat 7.6 pKi = 7.6 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1105 22 9 9 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10603365 16061 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1C(F)(F)F 10.1021/jm970499g
CHEMBL110913 16061 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 582 9 2 3 5.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1C(F)(F)F 10.1021/jm970499g
CHEMBL261608 217298 0 None -9 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 10.1021/jm070332f
44337023 115451 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 861 11 0 7 8.2 O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320770 115451 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 861 11 0 7 8.2 O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
44462338 212575 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCOC23CC[C@@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL83156 212575 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCOC23CC[C@@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1016/s0960-894x(02)00506-1
145948847 174259 0 None -28 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1123 22 9 9 5.5 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299423 174259 0 None -28 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1123 22 9 9 5.5 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10722607 11977 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 624 10 2 3 6.6 CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)C(c1ccccc1)c1ccccc1 10.1021/jm970499g
CHEMBL106106 11977 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 624 10 2 3 6.6 CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl)C(c1ccccc1)c1ccccc1 10.1021/jm970499g
10698708 116567 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 592 9 2 3 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Br 10.1021/jm970499g
CHEMBL323274 116567 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 592 9 2 3 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Br 10.1021/jm970499g
10697884 171246 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 548 9 2 3 5.0 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL421408 171246 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 548 9 2 3 5.0 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
44408625 175501 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 465 4 0 1 7.4 CN(C(=O)c1ccccc1-c1ccccc1)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL436951 175501 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 465 4 0 1 7.4 CN(C(=O)c1ccccc1-c1ccccc1)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44315590 174587 0 None 1 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 774 14 1 8 7.5 CCNC(=O)Cn1c(=O)n(C2CCN(CC[C@@H](/C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(02)00462-6
CHEMBL430609 174587 0 None 1 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 774 14 1 8 7.5 CCNC(=O)Cn1c(=O)n(C2CCN(CC[C@@H](/C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(02)00462-6
CHEMBL2371978 216951 0 None 30 3 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm061369n
135413536 7236 85 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
230 7236 85 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
3490 7236 85 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
6918365 7236 85 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
CHEMBL1471 7236 85 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
DB00673 7236 85 None 50 2 Human 8.5 pKi = 8.5 Binding
Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cellsDisplacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells
ChEMBL 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10.1021/jm2017072
9918520 109528 0 None 2 2 Guinea pig 8.5 pKi = 8.5 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL305055 109528 0 None 2 2 Guinea pig 8.5 pKi = 8.5 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
46889466 14050 1 None 30 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 573 8 1 4 7.4 COCCNc1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1086004 14050 1 None 30 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 573 8 1 4 7.4 COCCNc1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
104943 62160 39 None 1862 3 Human 8.5 pKi = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00020-8
CHEMBL16192 62160 39 None 1862 3 Human 8.5 pKi = 8.5 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00020-8
44408100 147464 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 474 6 1 2 6.1 CC(C)N1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2005.10.072
CHEMBL381524 147464 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 474 6 1 2 6.1 CC(C)N1C[C@@](CO[C@H](C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)NC1=O 10.1016/j.bmcl.2005.10.072
44407972 147534 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 9 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381825 147534 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 653 9 1 6 5.7 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
44338583 12568 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 468 6 1 3 5.2 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F 10.1016/s0960-894x(02)00956-3
CHEMBL107875 12568 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 468 6 1 3 5.2 Fc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1F 10.1016/s0960-894x(02)00956-3
44358280 33651 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 1 3 5.2 Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL136360 33651 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 446 6 1 3 5.2 Cc1cccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44358334 33812 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL136504 33812 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 364 6 1 3 4.2 Clc1cc(Cl)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44358569 123570 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 533 11 1 5 4.1 NC(=O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL337789 123570 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 533 11 1 5 4.1 NC(=O)COCCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358323 125757 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 1 4 5.2 C[C@H](OC[C@@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL342443 125757 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 1 4 5.2 C[C@H](OC[C@@H](c1ccccc1)N1CCN(CC(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44315573 110573 0 None 1 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 707 12 1 7 8.3 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL308983 110573 0 None 1 3 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 707 12 1 7 8.3 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44337371 12063 0 None 4 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 720 7 1 4 6.8 O=C(c1cc(Br)cc(Br)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL106572 12063 0 None 4 2 Human 8.5 pKi = 8.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 720 7 1 4 6.8 O=C(c1cc(Br)cc(Br)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
25129135 179376 0 None -7 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
CHEMBL448998 179376 0 None -7 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
9918479 64386 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 748 14 1 7 6.7 CN(C/C(=N\OCCCS(=O)(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166827 64386 0 None -1 2 Human 8.5 pKi = 8.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 748 14 1 7 6.7 CN(C/C(=N\OCCCS(=O)(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
22000062 83333 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1cnccc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206268 83333 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1cnccc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
145948809 174257 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1231 22 9 9 5.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299402 174257 0 None 1 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1231 22 9 9 5.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44611294 97849 0 None - 1 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 329 7 3 3 0.9 NC(=O)[C@H](Cc1cccc(F)c1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2397494 97849 0 None - 1 Rat 8.5 pKi = 8.5 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 329 7 3 3 0.9 NC(=O)[C@H](Cc1cccc(F)c1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
10239000 86556 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 1 3 5.3 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N(C)C)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
CHEMBL211888 86556 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 488 6 1 3 5.3 C[C@@H](OC[C@]1(c2ccccc2)C[C@](N)(C(=O)N(C)C)C1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2006.04.031
11467400 13278 0 None 3 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 587 8 1 4 7.2 CCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
CHEMBL1082735 13278 0 None 3 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 587 8 1 4 7.2 CCN(CCO)c1cc(-c2ccccc2Cl)c(N(C)C(=O)C(C)(C)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cn1 10.1016/j.bmcl.2010.04.008
9869764 147320 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1ccncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL381058 147320 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1ccncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
145948955 174266 0 None 7 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299466 174266 0 None 7 4 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44409008 81891 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 551 5 0 5 5.5 Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL203605 81891 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 551 5 0 5 5.5 Cc1ccccc1-c1cnc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
10530741 15965 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1F 10.1021/jm970499g
CHEMBL110355 15965 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 552 8 2 3 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1F 10.1021/jm970499g
10115747 147934 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 464 5 1 2 5.5 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL382771 147934 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 464 5 1 2 5.5 C[C@@H](OC[C@@]1(c2ccc(F)cc2)CN(C)C(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL2419540 217220 0 None -4 4 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
46227360 209361 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611924 209361 0 None 1 4 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44138555 199951 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL523156 199951 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
44408766 103699 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1cccnc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL265986 103699 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1cccnc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
10507650 170109 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 591 9 3 4 4.6 CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL419004 170109 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 591 9 3 4 4.6 CNC(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
90644635 119483 0 None 6 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.9 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288170 119483 0 None 6 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.9 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304460 119483 0 None 6 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.9 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N(C)[C@H](Cc3ccccc3)C(=O)NCCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44408033 81547 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 540 6 1 4 5.6 CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
CHEMBL203111 81547 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 540 6 1 4 5.6 CO/N=C(/C)CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1 10.1016/j.bmcl.2005.10.077
44337414 15987 0 None 5 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 889 13 2 7 9.1 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110507 15987 0 None 5 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 889 13 2 7 9.1 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
46227362 209363 0 None -301 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL611926 209363 0 None -301 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
44314154 211846 0 None 24 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 585 10 1 5 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCNCC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77265 211846 0 None 24 2 Human 7.5 pKi = 7.5 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 585 10 1 5 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCNCC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44334845 115684 0 None - 1 Human 7.5 pKi = 7.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 725 6 0 7 5.2 COc1ccc(OC)c(S(=O)(=O)N2CCC3(CC2)C2C(=O)N(c4ccccc4)C(=O)C2CN3C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00659-5
CHEMBL321098 115684 0 None - 1 Human 7.5 pKi = 7.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 725 6 0 7 5.2 COc1ccc(OC)c(S(=O)(=O)N2CCC3(CC2)C2C(=O)N(c4ccccc4)C(=O)C2CN3C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00659-5
3668 8342 42 None -38 10 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
5311081 8342 42 None -38 10 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL333357 8342 42 None -38 10 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL589982 8342 42 None -38 10 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
44334666 11399 0 None - 1 Human 7.5 pKi = 7.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 736 4 1 7 4.5 O=C1COc2ccc(S(=O)(=O)N3CCC4(CC3)C3C(=O)N(c5ccccc5)C(=O)C3CN4C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)cc2N1 10.1016/s0960-894x(02)00659-5
CHEMBL102917 11399 0 None - 1 Human 7.5 pKi = 7.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 736 4 1 7 4.5 O=C1COc2ccc(S(=O)(=O)N3CCC4(CC3)C3C(=O)N(c5ccccc5)C(=O)C3CN4C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)cc2N1 10.1016/s0960-894x(02)00659-5
90663661 113488 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL 1140 33 10 15 -0.0 CCCN1C(=O)C2NC(c3ccc(OCC(=O)NCCNC(=O)C(N)CC(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](Cc4ccccc4)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)cc3)=NC2N(CCC)C1=O 10.1021/jm00391a046
CHEMBL3143946 113488 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL 1140 33 10 15 -0.0 CCCN1C(=O)C2NC(c3ccc(OCC(=O)NCCNC(=O)C(N)CC(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](Cc4ccccc4)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)cc3)=NC2N(CCC)C1=O 10.1021/jm00391a046
118730935 124937 0 None -10715 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 699 15 6 7 1.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408521 124937 0 None -10715 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 699 15 6 7 1.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
44334708 11405 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 609 2 0 4 5.4 CC(C)(C)C(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL102932 11405 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 609 2 0 4 5.4 CC(C)(C)C(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
118731117 124951 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 740 17 7 7 2.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2ccccc2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408734 124951 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 740 17 7 7 2.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2ccccc2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
56682292 72684 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 808 15 2 6 7.7 O=C(COCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
CHEMBL1835845 72684 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 808 15 2 6 7.7 O=C(COCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
90644631 118722 0 None -12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 684 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288167 118722 0 None -12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 684 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCO)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44358248 33446 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 484 8 1 3 6.2 C=Cc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1C=C 10.1016/s0960-894x(02)00956-3
CHEMBL136187 33446 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 484 8 1 3 6.2 C=Cc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1C=C 10.1016/s0960-894x(02)00956-3
20599018 206182 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 517 2 1 2 6.5 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL591075 206182 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 517 2 1 2 6.5 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
44304398 109463 0 None - 1 Human 7.5 pKi = 7.5 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 459 2 1 2 5.3 CC1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
CHEMBL304638 109463 0 None - 1 Human 7.5 pKi = 7.5 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 459 2 1 2 5.3 CC1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
16655023 114218 2 None -251 7 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]substance P from human cloned NK1 receptorDisplacement of [3H]substance P from human cloned NK1 receptor
ChEMBL 481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 10.1016/j.bmc.2007.03.053
CHEMBL318235 114218 2 None -251 7 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]substance P from human cloned NK1 receptorDisplacement of [3H]substance P from human cloned NK1 receptor
ChEMBL 481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 10.1016/j.bmc.2007.03.053
44408911 147341 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 355 4 1 3 5.8 Cc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL381179 147341 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 355 4 1 3 5.8 Cc1ccccc1-c1ccccc1/C=N/Nc1c(Cl)cncc1Cl 10.1016/j.bmcl.2005.11.047
73212517 111378 0 None 31 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 475 7 3 3 3.9 CC(C)(C(=O)N[C@H](C(=O)NCCN)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104775 111378 0 None 31 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 475 7 3 3 3.9 CC(C)(C(=O)N[C@H](C(=O)NCCN)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
73212516 111380 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 502 5 1 3 4.7 CC(C)(C(=O)N[C@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
CHEMBL3104777 111380 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 502 5 1 3 4.7 CC(C)(C(=O)N[C@H](C(=O)N1CCOCC1)c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.12.033
90644626 119530 0 None 2 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288164 119530 0 None 2 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305163 119530 0 None 2 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44304340 209649 0 None - 1 Human 6.5 pKi = 6.5 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 503 3 1 4 4.4 COC(=O)C1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
CHEMBL62597 209649 0 None - 1 Human 6.5 pKi = 6.5 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 503 3 1 4 4.4 COC(=O)C1c2ccccc2NC(=O)CN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
44337270 115379 0 None -4 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 665 8 3 6 4.5 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccc(O)cc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320486 115379 0 None -4 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 665 8 3 6 4.5 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccc(O)cc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44337007 117185 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 863 9 2 7 8.5 O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL324416 117185 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 863 9 2 7 8.5 O=C(CN(N1CCC(O)(c2ccccc2)CC1)N1CCC(O)(c2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
52937273 69293 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 458 3 0 2 4.7 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
CHEMBL1782137 69293 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 458 3 0 2 4.7 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm1016285
44281572 117169 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 705 10 2 6 8.7 CO/N=C(\COC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32431 117169 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 705 10 2 6 8.7 CO/N=C(\COC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281776 121029 0 None -3 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 568 11 1 5 7.3 CO/N=C(\COCc1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33302 121029 0 None -3 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 568 11 1 5 7.3 CO/N=C(\COCc1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
54581461 68037 0 None -2089 4 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
CHEMBL1766207 68037 0 None -2089 4 Rat 6.5 pKi = 6.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1143 29 10 12 4.0 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccc(OC)c(OC)c1 10.1021/jm101023r
86275687 150419 0 None -776 2 Human 4.5 pKi = 4.5 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 374 2 0 7 3.0 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)cc2)C3C)n1 nan
CHEMBL3899877 150419 0 None -776 2 Human 4.5 pKi = 4.5 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 374 2 0 7 3.0 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)cc2)C3C)n1 nan
10007108 170744 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 527 2 1 3 5.4 Cc1cc(C)c(C(=O)N2CCC3(CC2)NC(=O)N(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c(C)c1 10.1016/s0960-894x(02)00488-2
CHEMBL420787 170744 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 527 2 1 3 5.4 Cc1cc(C)c(C(=O)N2CCC3(CC2)NC(=O)N(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c(C)c1 10.1016/s0960-894x(02)00488-2
44380475 65558 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 675 11 1 4 9.2 CO/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168770 65558 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 675 11 1 4 9.2 CO/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44314476 111859 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL311387 111859 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
24768355 175674 0 None -53 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL438389 175674 0 None -53 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
24768355 175674 0 None -53 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
CHEMBL438389 175674 0 None -53 5 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1077 22 9 9 4.7 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
44281713 106439 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 600 13 1 7 6.7 CO/N=C(\COCc1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284396 106439 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 600 13 1 7 6.7 CO/N=C(\COCc1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281788 106762 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 583 11 2 6 5.9 CO/N=C(\CNC(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286640 106762 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 583 11 2 6 5.9 CO/N=C(\CNC(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
73353536 97842 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 6 3 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1NCC[C@H]1c1ccccc1 10.1021/jm400209h
CHEMBL2397487 97842 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 6 3 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1NCC[C@H]1c1ccccc1 10.1021/jm400209h
2110 9743 38 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
219077 9743 38 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
3480 9743 38 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
CHEMBL346178 9743 38 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
DB04872 9743 38 None -1258 6 Human 6.5 pKi = 6.5 Binding
Binding affinity to human NK1 receptor by radioligand binding assayBinding affinity to human NK1 receptor by radioligand binding assay
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1016/j.bmcl.2011.02.033
10600014 174649 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 459 7 2 3 4.9 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)NC(c1ccccc1)c1ccccc1 10.1021/jm970499g
CHEMBL431070 174649 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranesIn vitro binding affinity towards Tachykinin receptor 1 to displace [3H][Sar9Met(O2)11]-SP (1 nM) binding to rabbit whole brain membranes
ChEMBL 459 7 2 3 4.9 COc1ccccc1C/N=C(\S)N1CCC[C@H]1C(=O)NC(c1ccccc1)c1ccccc1 10.1021/jm970499g
10007326 113643 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 535 2 1 3 5.6 O=C(c1cccc2ccccc12)N1CCC2(CC1)NC(=O)N(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C2=O 10.1016/s0960-894x(02)00488-2
CHEMBL314499 113643 0 None - 1 Human 6.5 pKi = 6.5 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 535 2 1 3 5.6 O=C(c1cccc2ccccc12)N1CCC2(CC1)NC(=O)N(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C2=O 10.1016/s0960-894x(02)00488-2
44314481 211715 0 None 10 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL76334 211715 0 None 10 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
145948839 174258 0 None -85 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1137 22 8 9 5.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299415 174258 0 None -85 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1137 22 8 9 5.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
145948968 174268 0 None -8 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1095 22 9 9 4.8 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299479 174268 0 None -8 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1095 22 9 9 4.8 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
45271306 202451 0 None -645 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL556537 202451 0 None -645 4 Rat 7.5 pKi = 7.5 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1438 33 14 16 3.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]1O[C@H](CC)[C@@H](O)[C@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
118730934 124936 0 None -363 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 835 15 6 7 4.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408520 124936 0 None -363 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 835 15 6 7 4.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
51003494 65096 0 None -44 3 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]SP from human cloned NK1 receptorDisplacement of [125I]SP from human cloned NK1 receptor
ChEMBL 556 8 0 4 3.5 CN(Cc1ccc(F)cc1)C(=O)[C@@]1(c2ccc(Cl)c(Cl)c2)C[C@H]1CN1CCN(S(=O)(=O)N(C)C)CC1 10.1016/j.bmcl.2010.12.135
CHEMBL1682680 65096 0 None -44 3 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]SP from human cloned NK1 receptorDisplacement of [125I]SP from human cloned NK1 receptor
ChEMBL 556 8 0 4 3.5 CN(Cc1ccc(F)cc1)C(=O)[C@@]1(c2ccc(Cl)c(Cl)c2)C[C@H]1CN1CCN(S(=O)(=O)N(C)C)CC1 10.1016/j.bmcl.2010.12.135
44337355 12118 0 None -26 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 581 7 2 4 5.2 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4cc[nH]c4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106877 12118 0 None -26 2 Human 7.5 pKi = 7.5 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 581 7 2 4 5.2 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4cc[nH]c4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
118731114 124948 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 862 16 7 7 4.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408731 124948 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 862 16 7 7 4.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
44363948 43151 0 None 5 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 653 11 0 5 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144668 43151 0 None 5 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 653 11 0 5 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363912 125535 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 12 0 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL341843 125535 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 12 0 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10507772 116530 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccc2ccccc2c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL323044 116530 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 598 9 2 3 6.1 CN(Cc1ccc2ccccc2c1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
44336987 115726 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 791 11 0 5 9.2 O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL321154 115726 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 791 11 0 5 9.2 O=C(CN(N1CCC(Cc2ccccc2)CC1)N1CCC(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
9809308 212503 0 None - 1 Human 5.4 pKi = 5.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 624 6 0 4 5.4 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)CN3CCC(Cc4ccccc4)CC3)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL82552 212503 0 None - 1 Human 5.4 pKi = 5.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 624 6 0 4 5.4 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)CN3CCC(Cc4ccccc4)CC3)CC2)C1=O 10.1016/s0960-894x(02)00488-2
4189 213701 96 None -27 34 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 213701 96 None -27 34 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 213701 96 None -27 34 Human 5.4 pKi = 5.4 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
44408628 147141 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 409 5 1 1 6.7 FC(F)(F)c1cc(CNCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL380827 147141 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 409 5 1 1 6.7 FC(F)(F)c1cc(CNCc2ccccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44380764 127506 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 689 11 1 5 8.6 CN(C)/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354822 127506 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 689 11 1 5 8.6 CN(C)/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44363978 47264 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 697 12 1 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL148282 47264 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 697 12 1 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
11801041 117231 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 9 1 3 5.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL324667 117231 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 562 9 1 3 5.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
44334654 114978 0 None - 1 Human 7.4 pKi = 7.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 653 3 0 5 4.8 CN1C(=O)C2CN(S(=O)(=O)c3ccc4ccccc4c3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O 10.1016/s0960-894x(02)00659-5
CHEMBL319653 114978 0 None - 1 Human 7.4 pKi = 7.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 653 3 0 5 4.8 CN1C(=O)C2CN(S(=O)(=O)c3ccc4ccccc4c3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O 10.1016/s0960-894x(02)00659-5
52937270 69294 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 501 5 2 3 3.4 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
CHEMBL1782138 69294 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]SP from human recombinant NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 501 5 2 3 3.4 CC(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/jm1016285
145948809 174257 0 None -11 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1231 22 9 9 5.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299402 174257 0 None -11 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1231 22 9 9 5.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44314945 211775 0 None 9 2 Human 7.4 pKi = 7.4 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 728 17 1 7 6.9 CCOCCCNC(=O)CN1CCN(CCC(/C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)=N/OC)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(00)00464-9
CHEMBL76727 211775 0 None 9 2 Human 7.4 pKi = 7.4 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 728 17 1 7 6.9 CCOCCCNC(=O)CN1CCN(CCC(/C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)=N/OC)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(00)00464-9
44281392 106734 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 12 1 5 8.8 CO/N=C(\COCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286433 106734 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 12 1 5 8.8 CO/N=C(\COCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44323563 213793 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 322 4 2 3 3.4 COc1ccccc1CN[C@H]1CCCN[C@]12CCc1ccccc12 10.1016/0960-894X(95)00481-8
CHEMBL91475 213793 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranesBinding affinity measured by displacement of tritiated radiolabeled substance P from cloned human NK1 receptor expressed in CHO cell membranes
ChEMBL 322 4 2 3 3.4 COc1ccccc1CN[C@H]1CCCN[C@]12CCc1ccccc12 10.1016/0960-894X(95)00481-8
90644629 118436 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.8 CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
CHEMBL3286415 118436 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 711 12 2 6 5.8 CN(C)CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@](C)(CCN1CCC2(CC1)OC(=O)N(C)c1ccc(F)cc12)c1ccc(Cl)c(Cl)c1 10.1021/ml400528y
10300825 36716 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 0 5 4.8 COC(=O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL138839 36716 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 8 0 5 4.8 COC(=O)CN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44304301 210096 0 None - 1 Human 7.4 pKi = 7.4 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 445 2 1 2 5.8 CC1c2ccccc2NCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
CHEMBL64839 210096 0 None - 1 Human 7.4 pKi = 7.4 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 445 2 1 2 5.8 CC1c2ccccc2NCCN1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/S0960-894X(97)00353-3
CHEMBL5286117 201111 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cellsInhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cells
ChEMBL 484 3 1 3 5.2 CC(=O)N1Cc2[nH]c3ccccc3c2C[C@H]1C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.6b01029
90644616 119513 0 None 25 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288159 119513 0 None 25 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304856 119513 0 None 25 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
90644610 119526 0 None 15 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288156 119526 0 None 15 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305158 119526 0 None 15 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
2110 9743 38 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
219077 9743 38 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
3480 9743 38 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
CHEMBL346178 9743 38 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
DB04872 9743 38 None -1258 6 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm5017413
44338557 16120 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 330 6 1 3 3.5 Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL111244 16120 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 330 6 1 3 3.5 Clc1cccc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44363926 45843 0 None 3 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 669 11 1 6 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL146882 45843 0 None 3 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 669 11 1 6 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314867 164106 0 None 8 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL407749 164106 0 None 8 2 Human 8.4 pKi = 8.4 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44408755 81813 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1cccnc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL203481 81813 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 480 4 0 2 7.0 Cc1ccccc1-c1cccnc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
10032693 116539 0 None 2 2 Human 8.4 pKi = 8.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 703 10 1 5 8.3 CO/N=C(\CN(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32309 116539 0 None 2 2 Human 8.4 pKi = 8.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 703 10 1 5 8.3 CO/N=C(\CN(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
107686 10152 41 None 15 2 Rat 8.4 pKi = 8.4 Binding
Tested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranesTested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
3522 10152 41 None 15 2 Rat 8.4 pKi = 8.4 Binding
Tested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranesTested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
CHEMBL131171 10152 41 None 15 2 Rat 8.4 pKi = 8.4 Binding
Tested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranesTested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranes
ChEMBL 438 5 1 3 5.1 COc1ccccc1CC(=N)N1C[C@H]2[C@@H](C1)C(CCC2=O)(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80650-2
9939040 11782 7 None 2 4 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL105060 11782 7 None 2 4 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL2419544 217224 0 None -14 3 Rat 8.4 pKi = 8.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
10602943 114195 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 10.1021/jm970499g
CHEMBL318084 114195 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 8 2 4 5.1 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C#N)c1 10.1021/jm970499g
9824321 82217 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
CHEMBL204206 82217 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NCC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
9846661 83350 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1cnccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL206294 83350 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1cnccc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
44380457 64890 0 None 3 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 0 7 6.6 COC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167613 64890 0 None 3 2 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 698 12 0 7 6.6 COC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
9939307 210265 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL66106 210265 0 None -2 4 Human 8.3 pKi = 8.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10531666 15963 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 601 9 2 4 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL110340 15963 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 601 9 2 4 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL3609615 218608 0 None -24 4 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL None None None C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
44318312 111643 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCOC23CC[C@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1016/s0960-894x(02)00506-1
CHEMBL311027 111643 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human Tachykinin receptor 1Binding affinity to human Tachykinin receptor 1
ChEMBL 395 2 1 3 4.8 Fc1ccc([C@@H]2NCCOC23CC[C@H](c2ccccc2C(F)(F)F)CO3)cc1 10.1016/s0960-894x(02)00506-1
86275451 166872 0 None -5623 3 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 420 4 0 8 3.8 CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
CHEMBL4108623 166872 0 None -5623 3 Human 4.4 pKi = 4.4 Binding
Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 420 4 0 8 3.8 CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
57396389 75143 0 None - 1 Human 4.4 pKi = 4.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 734 14 4 6 6.4 CC(C)C[C@H](NC(=O)CNC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2011.08.042
CHEMBL1916636 75143 0 None - 1 Human 4.4 pKi = 4.4 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 734 14 4 6 6.4 CC(C)C[C@H](NC(=O)CNC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2011.08.042
44407890 81949 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL203655 81949 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@@H](OC[C@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
44337208 12011 0 None -38 2 Human 7.4 pKi = 7.4 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106300 12011 0 None -38 2 Human 7.4 pKi = 7.4 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44282003 106887 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 689 11 1 5 8.6 CO/N=C(\CN(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL287523 106887 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 689 11 1 5 8.6 CO/N=C(\CN(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44334500 11308 0 None - 1 Human 5.4 pKi = 5.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 599 5 1 6 4.1 COc1ccc(C(=O)N2CC3C(=O)N(Cc4cc(C(F)(F)F)cc(C(F)(F)F)c4)C(=O)C3C23CCNCC3)cc1OC 10.1016/s0960-894x(02)00659-5
CHEMBL102332 11308 0 None - 1 Human 5.4 pKi = 5.4 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 599 5 1 6 4.1 COc1ccc(C(=O)N2CC3C(=O)N(Cc4cc(C(F)(F)F)cc(C(F)(F)F)c4)C(=O)C3C23CCNCC3)cc1OC 10.1016/s0960-894x(02)00659-5
44281744 120251 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 739 11 1 6 7.8 CO/N=C(\CN(C)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33194 120251 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 739 11 1 6 7.8 CO/N=C(\CN(C)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363877 45924 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 709 12 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL146947 45924 0 None 3 2 Human 7.4 pKi = 7.4 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 709 12 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44409004 81214 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 515 4 0 1 7.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Br 10.1016/j.bmcl.2005.11.047
CHEMBL202720 81214 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 515 4 0 1 7.4 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1Br 10.1016/j.bmcl.2005.11.047
46227361 209362 0 None -85 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611925 209362 0 None -85 4 Rat 7.4 pKi = 7.4 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44318565 212708 0 None - 1 Human 7.3 pKi = 7.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 528 3 2 3 5.2 Cc1cccc(NC(=O)N2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 10.1016/s0960-894x(02)00488-2
CHEMBL84161 212708 0 None - 1 Human 7.3 pKi = 7.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 528 3 2 3 5.2 Cc1cccc(NC(=O)N2CCC3(CC2)NC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C3=O)c1 10.1016/s0960-894x(02)00488-2
CHEMBL2372339 217001 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesAbility to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O 10.1021/jm00391a046
44318497 212779 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 563 3 0 3 5.9 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3cccc4ccccc34)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL84873 212779 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 563 3 0 3 5.9 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3cccc4ccccc34)CC2)C1=O 10.1016/s0960-894x(02)00488-2
145948965 174267 0 None -18 4 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1183 22 9 9 6.1 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299476 174267 0 None -18 4 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1183 22 9 9 6.1 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44314872 103647 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 740 13 1 7 6.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL265499 103647 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 740 13 1 7 6.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44337202 14747 0 None -5 2 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL109053 14747 0 None -5 2 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44337079 113973 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 877 11 2 7 7.5 CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccccc2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00645-5
CHEMBL316553 113973 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 877 11 2 7 7.5 CC(=O)NC1(c2ccccc2)CCN(N(CC(=O)N2CCN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2c2ccccc2)N2CCC(NC(C)=O)(c3ccccc3)CC2)CC1 10.1016/s0960-894x(02)00645-5
44337024 115453 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 793 11 0 7 6.9 O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL320771 115453 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 793 11 0 7 6.9 O=C(CN(N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
145948744 174254 0 None -47 4 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299371 174254 0 None -47 4 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1120 22 8 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
10769914 117927 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 601 10 3 3 5.5 CN(CCc1c[nH]c2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL326429 117927 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 601 10 3 3 5.5 CN(CCc1c[nH]c2ccccc12)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL2112592 216019 0 None -1 2 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL None None None CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(OC(C)(C)C)cc2)NC(=O)CNC1=O 10.1021/jm00029a007
44380596 66126 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 13 1 6 8.7 COCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL170727 66126 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 706 13 1 6 8.7 COCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44408726 83335 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 419 4 1 3 6.3 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1Br 10.1016/j.bmcl.2005.11.047
CHEMBL206274 83335 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 419 4 1 3 6.3 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1Br 10.1016/j.bmcl.2005.11.047
10091563 46484 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 386 7 2 3 4.7 COc1ccccc1CN[C@H]1CCCN[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
CHEMBL147543 46484 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]BH-SP of the compound.
ChEMBL 386 7 2 3 4.7 COc1ccccc1CN[C@H]1CCCN[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm00104a018
44314861 174559 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL430416 174559 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
11801965 11992 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 616 9 2 3 6.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL106217 11992 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 616 9 2 3 6.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
10603279 14794 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C(N)=O)c1 10.1021/jm970499g
CHEMBL109080 14794 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 577 9 3 4 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccc(C(N)=O)c1 10.1021/jm970499g
9939307 210265 0 None -3 4 Guinea pig 8.3 pKi = 8.3 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66106 210265 0 None -3 4 Guinea pig 8.3 pKi = 8.3 Binding
In vitro binding to Tachykinin receptor 1In vitro binding to Tachykinin receptor 1
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44282001 106584 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 705 12 1 7 7.0 CO/N=C(\CN(C)C(=O)c1cc(OC)c(Br)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285422 106584 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 705 12 1 7 7.0 CO/N=C(\CN(C)C(=O)c1cc(OC)c(Br)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281571 117166 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 718 10 2 5 8.7 CO/N=C(\CN(C)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32430 117166 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 718 10 2 5 8.7 CO/N=C(\CN(C)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281976 117351 0 None -2 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 627 12 1 7 6.2 CO/N=C(\CN(C)C(=O)c1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32537 117351 0 None -2 2 Human 8.3 pKi = 8.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 627 12 1 7 6.2 CO/N=C(\CN(C)C(=O)c1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10321715 33478 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
CHEMBL136213 33478 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 452 6 1 3 4.4 Brc1cc(Br)cc(COCC(c2ccccc2)N2CCNCC2)c1 10.1016/s0960-894x(02)00956-3
44338618 116103 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
CHEMBL321892 116103 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
10393853 116489 0 None - 1 Human 8.3 pKi = 8.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 603 3 0 5 3.8 CS(=O)(=O)N1CC2C(=O)N(c3ccccc3)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 10.1016/s0960-894x(02)00659-5
CHEMBL322885 116489 0 None - 1 Human 8.3 pKi = 8.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 603 3 0 5 3.8 CS(=O)(=O)N1CC2C(=O)N(c3ccccc3)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 10.1016/s0960-894x(02)00659-5
2755911 82214 52 None 1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL2042018 82214 52 None 1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to NK1 receptor (unknown origin)Binding affinity to NK1 receptor (unknown origin)
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
2755911 82214 52 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
CHEMBL2042018 82214 52 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysisDisplacement of [3H]-SP1-7 from NK1 receptor (unknown origin) by scintillation counting analysis
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1021/ml5002954
2755911 82214 52 None -1 2 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1016/j.bmcl.2018.06.009
CHEMBL2042018 82214 52 None -1 2 Rat 8.3 pKi = 8.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL 298 6 2 3 2.0 NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1016/j.bmcl.2018.06.009
15887537 115823 0 None 3 3 Human 8.3 pKi = 8.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL321270 115823 0 None 3 3 Human 8.3 pKi = 8.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
145948968 174268 0 None -1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1095 22 9 9 4.8 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299479 174268 0 None -1 4 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from recombinant human neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1095 22 9 9 4.8 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44364030 43421 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144887 43421 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 711 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44282004 128539 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 675 11 2 5 8.3 CO/N=C(\CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL35891 128539 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 675 11 2 5 8.3 CO/N=C(\CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
90644608 119484 0 None 79 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288155 119484 0 None 79 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304468 119484 0 None 79 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 2 6 5.7 CN1C(=O)OC2(CCN(CCC[C@@H](C(=O)N(C)[C@@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44338652 115387 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00956-3
CHEMBL320544 115387 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00956-3
46224897 205891 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 3 1 2 5.1 Cc1cc(F)ccc1C1CNCC2CN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)N21 10.1016/j.bmcl.2009.11.078
CHEMBL589130 205891 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 475 3 1 2 5.1 Cc1cc(F)ccc1C1CNCC2CN(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)C(=O)N21 10.1016/j.bmcl.2009.11.078
73350555 97843 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 6 3 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1NCC[C@@H]1c1ccccc1 10.1021/jm400209h
CHEMBL2397488 97843 0 None - 1 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 6 3 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1NCC[C@@H]1c1ccccc1 10.1021/jm400209h
2098 10466 36 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
36511 10466 36 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
3805 10466 36 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
3835 10466 36 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
CHEMBL235363 10466 36 None -2 6 Guinea pig 7.3 pKi = 7.3 Binding
Evaluated for the binding affinity against NK1 receptorEvaluated for the binding affinity against NK1 receptor
ChEMBL None None None None 10.1021/jm00073a022
44334581 12005 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 629 3 1 5 6.0 O=C1C2CN(C(=O)c3sc4ccccc4c3Cl)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL106273 12005 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 629 3 1 5 6.0 O=C1C2CN(C(=O)c3sc4ccccc4c3Cl)C3(CCNCC3)C2C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
2090 9543 25 None -309 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
5311312 9543 25 None -309 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
CHEMBL437797 9543 25 None -309 4 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
445694 126807 81 None - 1 Rat 5.3 pKi = 5.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 164 3 2 2 0.0 NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL350320 126807 81 None - 1 Rat 5.3 pKi = 5.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 164 3 2 2 0.0 NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
11305162 81545 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 437 4 0 1 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL203109 81545 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 437 4 0 1 6.7 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
44334489 114075 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 559 3 0 5 4.5 CN1C(=O)C2CN(Cc3cccs3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O 10.1016/s0960-894x(02)00659-5
CHEMBL317209 114075 0 None - 1 Human 6.3 pKi = 6.3 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 559 3 0 5 4.5 CN1C(=O)C2CN(Cc3cccs3)C3(CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)CC3)C2C1=O 10.1016/s0960-894x(02)00659-5
44337354 12229 0 None -58 2 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 656 8 2 7 5.3 CC(=O)Nc1nc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cs1 10.1016/s0960-894x(02)00645-5
CHEMBL107469 12229 0 None -58 2 Human 7.3 pKi = 7.3 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 656 8 2 7 5.3 CC(=O)Nc1nc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cs1 10.1016/s0960-894x(02)00645-5
44314834 211928 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 667 11 0 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78092 211928 0 None 2 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 667 11 0 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281771 106416 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 630 14 1 8 6.7 CO/N=C(\COCc1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284269 106416 0 None -1 2 Human 7.3 pKi = 7.3 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 630 14 1 8 6.7 CO/N=C(\COCc1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
7088460 206059 1 None - 1 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL590275 206059 1 None - 1 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm901352b
70689371 85154 0 None - 1 Human 7.3 pKi = 7.3 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL 1372 34 14 16 -1.0 CC(C)C[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)N1CC[C@@]2(CCCN2C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)C2CCCN2)C1=O 10.1016/s0960-894x(98)00219-4
CHEMBL2110361 85154 0 None - 1 Human 7.3 pKi = 7.3 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL 1372 34 14 16 -1.0 CC(C)C[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)N1CC[C@@]2(CCCN2C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)C2CCCN2)C1=O 10.1016/s0960-894x(98)00219-4
46227360 209361 0 None -151 4 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL611924 209361 0 None -151 4 Rat 6.3 pKi = 6.3 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 18 10 12 4.6 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
18546495 147491 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 437 4 0 1 6.6 CN(C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL381744 147491 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 437 4 0 1 6.6 CN(C(=O)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
44380680 64361 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 673 11 1 3 10.0 CC/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166759 64361 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 673 11 1 3 10.0 CC/C=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44318593 174773 0 None - 1 Human 6.2 pKi = 6.2 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 552 4 2 3 5.0 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(CCc1c[nH]c3ccccc13)C2=O 10.1016/s0960-894x(02)00488-2
CHEMBL431974 174773 0 None - 1 Human 6.2 pKi = 6.2 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 552 4 2 3 5.0 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)NC(=O)N(CCc1c[nH]c3ccccc13)C2=O 10.1016/s0960-894x(02)00488-2
44281787 169978 0 None -14 2 Human 7.2 pKi = 7.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 597 11 1 6 6.2 CO/N=C(\CN(C)C(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL418224 169978 0 None -14 2 Human 7.2 pKi = 7.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 597 11 1 6 6.2 CO/N=C(\CN(C)C(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
49863733 22104 0 None 2 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214026 22104 0 None 2 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P frome human NK1 receptorDisplacement of [3H]substance P frome human NK1 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
118730932 124934 0 None -2951 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 834 15 7 7 3.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408518 124934 0 None -2951 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 834 15 7 7 3.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1016/j.ejmech.2014.12.033
44364003 125773 0 None 9 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 11 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL342572 125773 0 None 9 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 11 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10295489 147120 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 418 5 2 2 4.4 O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)N1 10.1016/j.bmcl.2005.10.072
CHEMBL380716 147120 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 418 5 2 2 4.4 O=C1NC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)N1 10.1016/j.bmcl.2005.10.072
44281957 106592 0 None 27 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 703 10 1 5 8.1 CO/N=C(\C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285475 106592 0 None 27 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 703 10 1 5 8.1 CO/N=C(\C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10010096 106666 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 719 10 1 6 8.6 CO/N=C(\CN(C)C(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285986 106666 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 719 10 1 6 8.6 CO/N=C(\CN(C)C(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
24768356 162641 0 None -4 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
CHEMBL406030 162641 0 None -4 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm070332f
10675169 115436 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 605 9 2 4 4.9 CN(C)C(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
CHEMBL320758 115436 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 605 9 2 4 4.9 CN(C)C(=O)c1ccccc1NC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1 10.1021/jm970499g
44408846 147323 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL381081 147323 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 550 5 0 4 6.1 Cc1ccccc1-c1ccc(N2CCN(C)CC2)nc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
14991605 97847 0 None - 1 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 8 3 3 1.2 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2397492 97847 0 None - 1 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 8 3 3 1.2 NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
10229773 82276 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 520 6 1 3 5.5 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCOCC1 10.1016/j.bmcl.2005.10.072
CHEMBL204296 82276 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 520 6 1 3 5.5 O=C1NC(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)CN1C1CCOCC1 10.1016/j.bmcl.2005.10.072
44407906 81483 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
CHEMBL203064 81483 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 715 11 1 6 6.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C/C(=N\OCCCN2CCOCC2)c2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/j.bmcl.2005.10.077
44408048 147336 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 9 1 6 6.1 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381157 147336 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 667 9 1 6 6.1 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCC(C)(C)N1CCOCC1 10.1016/j.bmcl.2005.10.077
44407903 147500 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 655 9 1 6 6.0 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 10.1016/j.bmcl.2005.10.077
CHEMBL381778 147500 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H] labelled Substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 655 9 1 6 6.0 C/C(CN1CCN(C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](Cc2c[nH]c3ccccc23)C1)=N/OCCN1CCSCC1 10.1016/j.bmcl.2005.10.077
44338586 13657 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
CHEMBL108422 13657 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 462 7 1 4 4.9 COc1ccccc1C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
44338584 14929 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 500 6 1 3 6.2 FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL109183 14929 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 500 6 1 3 6.2 FC(F)(F)c1cc(COCC(c2ccc(Cl)c(Cl)c2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
10187704 126202 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 556 11 1 6 5.1 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCCCc3nnn[nH]3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL344847 126202 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 556 11 1 6 5.1 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(CCCCc3nnn[nH]3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
20599010 206146 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 2 1 2 6.1 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL590833 206146 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 2 1 2 6.1 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
118730933 124935 0 None -389 2 Human 8.2 pKi = 8.2 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3408519 124935 0 None -389 2 Human 8.2 pKi = 8.2 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 698 15 7 7 1.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)Cc2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
10578261 15955 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 535 8 2 4 4.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 10.1021/jm970499g
CHEMBL110301 15955 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 535 8 2 4 4.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H]1CCCN1C(=O)Nc1cccnc1 10.1021/jm970499g
127033168 145552 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1021 17 7 8 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3780686 145552 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1021 17 7 8 5.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CC[C@@H](C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccccc3)C2)C1=O 10.1021/acsmedchemlett.5b00359
56668794 72683 0 None 17 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 806 15 2 5 8.9 O=C(CCCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
CHEMBL1835844 72683 0 None 17 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation countingDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting
ChEMBL 806 15 2 5 8.9 O=C(CCCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2011.08.027
44177145 202507 0 None -6 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1191 27 10 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
CHEMBL557188 202507 0 None -6 3 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membraneDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane
ChEMBL 1191 27 10 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900473p
9874473 48582 0 None 16 3 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 48582 0 None 16 3 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligandIn vitro binding affinity towards human Tachykinin receptor 1 was determined by using [3H]SP as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
71549635 167653 0 None -851 3 Human 5.2 pKi = 5.2 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 450 4 0 8 4.4 C[C@@H]1c2nnc(-c3csc(N(C)C)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 nan
CHEMBL4115030 167653 0 None -851 3 Human 5.2 pKi = 5.2 Binding
Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK1 receptor was evaluated in CHO recombinant cells which express the human NK1 receptor. Membrane suspensions were prepared from these cells. The following radioligand: [3H] substance P (PerkinElmer Cat#NET111520) was used in this assay. Binding assays were performed in a 50 mM Tris/5 mM MnCl2/150 mM NaCl/0.1% BSA at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 5 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Substance P) at increasing concentrations (diluted in assay buffer) and 2 nM [3H] substance P. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in 0.5% PEI for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 450 4 0 8 4.4 C[C@@H]1c2nnc(-c3csc(N(C)C)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1 nan
145948955 174266 0 None -18 4 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
CHEMBL4299466 174266 0 None -18 4 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation countingDisplacement of [3H]SP from rat neurokinin-1 receptor expressed in CHO cells incubated for 20 mins by liquid scintillation counting
ChEMBL 1091 22 8 9 5.0 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)N(C)C(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b01170
44314597 111128 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 599 10 0 5 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL310019 111128 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 599 10 0 5 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
118731113 124947 0 None -43651 2 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 670 14 8 7 1.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408730 124947 0 None -43651 2 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 670 14 8 7 1.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)NCc2ccccc2)C1=O 10.1016/j.ejmech.2014.12.033
44314298 211921 0 None 4 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 682 13 1 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78065 211921 0 None 4 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 682 13 1 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10001148 58219 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 402 6 2 2 5.3 CNC(c1ccccc1)C1(NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 10.1016/s0960-894x(01)00020-8
CHEMBL158212 58219 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligandBinding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H][Pro9]-SP as radioligand
ChEMBL 402 6 2 2 5.3 CNC(c1ccccc1)C1(NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 10.1016/s0960-894x(01)00020-8
CHEMBL5278537 200763 0 None - 1 Human 7.2 pKi = 7.2 Binding
Inhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cellsInhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cells
ChEMBL 746 11 3 6 6.7 CC(C)C[C@H](NC(=O)CNC(=O)OCc1ccccc1)C(=O)N1Cc2[nH]c3ccccc3c2C[C@H]1C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.6b01029
90644622 119522 0 None 25 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288162 119522 0 None 25 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305013 119522 0 None 25 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 697 12 3 6 5.6 CN1C(=O)OC2(CCN(CCC[C@@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44358413 33680 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 7 0 4 5.8 CCOC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL136389 33680 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 504 7 0 4 5.8 CCOC(=O)N1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358551 36107 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 514 8 1 6 4.3 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3nn[nH]n3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL138335 36107 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 514 8 1 6 4.3 FC(F)(F)c1cc(COCC(c2ccccc2)N2CCN(Cc3nn[nH]n3)CC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
20599010 206146 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 2 1 2 6.1 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
CHEMBL590833 206146 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human NK1 receptor expressed in CHO cells
ChEMBL 503 2 1 2 6.1 Cc1cc(F)ccc1[C@H]1CNCCN1C(=O)N1CCCC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2009.11.078
2089 9542 28 None -102 5 Human 6.2 pKi = 6.2 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
3795 9542 28 None -102 5 Human 6.2 pKi = 6.2 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
5311311 9542 28 None -102 5 Human 6.2 pKi = 6.2 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
CHEMBL217406 9542 28 None -102 5 Human 6.2 pKi = 6.2 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00219-4
90644612 119497 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288157 119497 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3304538 119497 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 669 10 2 6 5.5 CN1C(=O)OC2(CCN(CC[C@@H](C(=O)N(C)[C@H](C(=O)NCCN)c3ccccc3)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
90644618 119540 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3288160 119540 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
CHEMBL3305331 119540 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cellsDisplacement of [125I]-Bolton Hunter-substance P from human NK1 receptor expressed in human U373MG cells
ChEMBL 683 11 3 6 5.2 CN1C(=O)OC2(CCN(CC[C@](C)(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCN)c3ccc(Cl)c(Cl)c3)CC2)c2cc(F)ccc21 10.1021/ml400528y
44304381 108862 0 None - 1 Human 6.2 pKi = 6.2 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 507 3 2 2 6.0 O=C1CN(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(c2ccccc2)c2ccccc2N1 10.1016/S0960-894X(97)00353-3
CHEMBL302163 108862 0 None - 1 Human 6.2 pKi = 6.2 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 507 3 2 2 6.0 O=C1CN(C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(c2ccccc2)c2ccccc2N1 10.1016/S0960-894X(97)00353-3
7037588 206060 1 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 10.1021/jm901352b
CHEMBL590276 206060 1 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL 311 7 3 3 0.8 NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1 10.1021/jm901352b
44318874 212445 0 None - 1 Human 6.2 pKi = 6.2 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 581 3 0 3 6.1 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3c(Cl)cccc3Cl)CC2)C1=O 10.1016/s0960-894x(02)00488-2
CHEMBL82065 212445 0 None - 1 Human 6.2 pKi = 6.2 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 581 3 0 3 6.1 CN1C(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C2(CCN(C(=O)c3c(Cl)cccc3Cl)CC2)C1=O 10.1016/s0960-894x(02)00488-2
3198 212292 76 None -37 34 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 212292 76 None -37 34 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 212292 76 None -37 34 Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
131954513 168857 38 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting methodDisplacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting method
ChEMBL 357 2 0 4 4.3 COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F 10.1021/acsmedchemlett.7b00317
CHEMBL4160748 168857 38 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting methodDisplacement of [3H] substance P from recombinant human NK1 receptor expressed in CHO cells after 90 mins by scintillation counting method
ChEMBL 357 2 0 4 4.3 COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F 10.1021/acsmedchemlett.7b00317
11683187 206711 44 None -676 5 Human 5.2 pKi = 5.2 Binding
Binding affinity to NK1 receptorBinding affinity to NK1 receptor
ChEMBL 419 7 0 8 2.9 COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
CHEMBL594828 206711 44 None -676 5 Human 5.2 pKi = 5.2 Binding
Binding affinity to NK1 receptorBinding affinity to NK1 receptor
ChEMBL 419 7 0 8 2.9 COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 10.1016/j.bmcl.2009.11.097
8867347 67377 5 None -6 4 Human 5.2 pKi = 5.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 362 4 1 4 3.0 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccccc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760200 67377 5 None -6 4 Human 5.2 pKi = 5.2 Binding
Binding affinity to human NK1 receptorBinding affinity to human NK1 receptor
ChEMBL 362 4 1 4 3.0 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccccc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
44408821 82166 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 465 4 0 1 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL203928 82166 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 465 4 0 1 7.3 CN(C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
73352066 97846 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.3 C[C@H](c1ccccc1)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397491 97846 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.3 C[C@H](c1ccccc1)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(N)=O 10.1021/jm400209h
44363435 43962 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 785 14 0 5 9.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(Cc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145314 43962 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 785 14 0 5 9.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(Cc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44380733 65390 0 None 7 2 Human 8.2 pKi = 8.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 14 1 6 8.7 COCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168437 65390 0 None 7 2 Human 8.2 pKi = 8.2 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 14 1 6 8.7 COCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44363983 24938 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 769 15 2 7 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC(O)CO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL126970 24938 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 769 15 2 7 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC(O)CO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44281958 116464 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 646 10 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cncc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32273 116464 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 646 10 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cncc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44337289 114815 0 None 3 2 Human 8.2 pKi = 8.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 624 9 1 6 5.3 COc1cc(OC)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL319474 114815 0 None 3 2 Human 8.2 pKi = 8.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 624 9 1 6 5.3 COc1cc(OC)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
46227363 206444 0 None -28 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
CHEMBL592969 206444 0 None -28 4 Rat 8.2 pKi = 8.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1210 16 10 12 4.7 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1016/j.bmc.2009.08.035
10651575 11926 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 624 10 2 3 6.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
CHEMBL105847 11926 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 624 10 2 3 6.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1Cl 10.1021/jm970499g
25129133 195666 0 None -10 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
CHEMBL507340 195666 0 None -10 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm800389v
25129133 195666 0 None -10 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
CHEMBL507340 195666 0 None -10 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranesDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membranes
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2009.08.035
44380069 64391 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 714 14 0 6 8.1 CSCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166842 64391 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 714 14 0 6 8.1 CSCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
127031644 145612 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1007 16 7 8 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3781336 145612 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1007 16 7 8 5.3 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(C)[C@@H]2CCN(C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C[C@@H]2c2ccccc2)C1=O 10.1021/acsmedchemlett.5b00359
44337288 14817 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 632 7 1 4 6.6 O=C(c1cc(Cl)cc(Cl)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL109092 14817 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 632 7 1 4 6.6 O=C(c1cc(Cl)cc(Cl)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
52937467 69297 0 None -9 3 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL1782141 69297 0 None -9 3 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 820 14 7 7 3.4 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL2419538 217218 0 None -117 4 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC1(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCC1 10.1016/j.bmcl.2013.06.065
10140125 34053 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 471 7 0 4 5.1 N#CCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL136709 34053 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 471 7 0 4 5.1 N#CCN1CCN(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
20811360 37099 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 489 8 1 4 4.1 NC(=O)CN1CCN([C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
CHEMBL139150 37099 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 489 8 1 4 4.1 NC(=O)CN1CCN([C@H](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2)CC1 10.1016/s0960-894x(02)00956-3
44358247 125785 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 438 6 1 4 4.9 FC(F)(F)c1cc(COCC(c2cccs2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
CHEMBL342602 125785 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 438 6 1 4 4.9 FC(F)(F)c1cc(COCC(c2cccs2)N2CCNCC2)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00956-3
44338640 174868 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 482 7 1 4 4.4 COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
CHEMBL432627 174868 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 482 7 1 4 4.4 COc1c(Br)cc(Br)cc1COCC(c1ccccc1)N1CCNCC1 10.1016/s0960-894x(02)00956-3
44337324 13483 0 None -2 2 Human 7.2 pKi = 7.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 688 8 3 5 5.3 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4c[nH]c5ccccc45)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108364 13483 0 None -2 2 Human 7.2 pKi = 7.2 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 688 8 3 5 5.3 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4c[nH]c5ccccc45)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44314548 109686 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 663 11 0 7 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ncccn2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306052 109686 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 663 11 0 7 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ncccn2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281516 106658 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1ccc(F)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285929 106658 0 None -3 2 Human 7.2 pKi = 7.2 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1ccc(F)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
73352065 97838 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.2 C[C@](N)(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397483 97838 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 3 3 1.2 C[C@](N)(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
44550460 203816 0 None -5 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 537 8 0 3 5.9 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccccc2Cl)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
CHEMBL567198 203816 0 None -5 4 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in HEK293 cells
ChEMBL 537 8 0 3 5.9 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccccc2Cl)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
25129135 179376 0 None -1584 4 Rat 6.2 pKi = 6.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
CHEMBL448998 179376 0 None -1584 4 Rat 6.2 pKi = 6.2 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation countingDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
ChEMBL 1073 27 10 11 2.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1ccccc1 10.1021/jm800389v
73347011 96184 0 None 1 2 Human 4.1 pKi = 4.1 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 730 6 7 8 -0.6 COc1ccc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
CHEMBL2370511 96184 0 None 1 2 Human 4.1 pKi = 4.1 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 730 6 7 8 -0.6 COc1ccc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
44409000 175720 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 423 5 0 1 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL438801 175720 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 423 5 0 1 7.0 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
118731118 124952 0 None -1202 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 822 17 7 7 3.5 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2014.12.033
CHEMBL3408735 124952 0 None -1202 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 822 17 7 7 3.5 Cc1cc(O)cc(C)c1CC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)N(C)CC(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2014.12.033
44318486 112198 0 None - 1 Human 7.1 pKi = 7.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 613 6 1 4 5.3 O=C1NC2(CCN(S(=O)(=O)CCc3cccc4ccccc34)CC2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00488-2
CHEMBL311946 112198 0 None - 1 Human 7.1 pKi = 7.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 613 6 1 4 5.3 O=C1NC2(CCN(S(=O)(=O)CCc3cccc4ccccc34)CC2)C(=O)N1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00488-2
118731116 124950 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 876 17 7 7 4.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
CHEMBL3408733 124950 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysisDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells after 20 mins by liquid scintillation counting analysis
ChEMBL 876 17 7 7 4.8 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC(C)C)C1=O 10.1016/j.ejmech.2014.12.033
44281743 106415 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 11 1 5 9.1 CO/N=C(\C(C)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284244 106415 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 690 11 1 5 9.1 CO/N=C(\C(C)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44334630 116432 0 None - 1 Human 7.1 pKi = 7.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 684 4 0 7 4.8 Cc1noc(C)c1S(=O)(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL322453 116432 0 None - 1 Human 7.1 pKi = 7.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 684 4 0 7 4.8 Cc1noc(C)c1S(=O)(=O)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/s0960-894x(02)00659-5
CHEMBL5266880 200278 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cellsInhibition of [3H]SP binding to human neurokinin receptor 1 expressed in CHO cells
ChEMBL 498 4 2 3 5.3 CC(=O)NC1(C(=O)OCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCc2[nH]c3ccccc3c2C1 10.1021/acs.jmedchem.6b01029
10721590 14435 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 10 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
CHEMBL108847 14435 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 559 10 2 5 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1ccccc1[N+](=O)[O-] 10.1021/jm970499g
10746828 13714 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 650 9 2 3 6.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm970499g
CHEMBL108448 13714 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 650 9 2 3 6.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1/C(S)=N/Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm970499g
CHEMBL2372068 216955 0 None - 1 Human 7.1 pKi = 7.1 Binding
Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsCompound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cells
ChEMBL None None None NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N1CCC(Cc2ccccc2)[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1016/s0960-894x(98)00219-4
73212515 111381 0 None 125 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 559 8 1 4 4.7 CN(CCN1CCOCC1)C(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2013.12.033
CHEMBL3104778 111381 0 None 125 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 559 8 1 4 4.7 CN(CCN1CCOCC1)C(=O)[C@@H](NC(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccccc1 10.1016/j.bmcl.2013.12.033
44338510 15405 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00956-3
CHEMBL109514 15405 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-substance P from human NK1 receptor expressed in CHO cellsDisplacement of [3H]-substance P from human NK1 receptor expressed in CHO cells
ChEMBL 450 6 1 3 5.0 Fc1ccc(C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)N2CCNCC2)cc1 10.1016/s0960-894x(02)00956-3
57394644 75140 0 None - 1 Human 4.1 pKi = 4.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 721 10 4 6 4.3 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916633 75140 0 None - 1 Human 4.1 pKi = 4.1 Binding
Displacement of [3H]SP from human NK1 receptor expressed in CHO cellsDisplacement of [3H]SP from human NK1 receptor expressed in CHO cells
ChEMBL 721 10 4 6 4.3 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)NCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
44334582 168472 0 None - 1 Human 6.1 pKi = 6.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 597 3 0 5 4.1 COc1ccccc1C(=O)N1CC2C(=O)N(C)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 10.1016/s0960-894x(02)00659-5
CHEMBL413383 168472 0 None - 1 Human 6.1 pKi = 6.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 597 3 0 5 4.1 COc1ccccc1C(=O)N1CC2C(=O)N(C)C(=O)C2C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2 10.1016/s0960-894x(02)00659-5
73212519 111376 0 None 12 2 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 517 8 2 4 3.6 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 10.1016/j.bmcl.2013.12.033
CHEMBL3104773 111376 0 None 12 2 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]-Bolton Hunter-Substance P from human NK1 receptorDisplacement of [125I]-Bolton Hunter-Substance P from human NK1 receptor
ChEMBL 517 8 2 4 3.6 O=C(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)N[C@H](C(=O)NCCN1CCOCC1)c1ccccc1 10.1016/j.bmcl.2013.12.033
44304323 107360 0 None - 1 Human 6.1 pKi = 6.1 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 544 4 1 4 4.6 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1CN1CCOCC1 10.1016/S0960-894X(97)00353-3
CHEMBL291650 107360 0 None - 1 Human 6.1 pKi = 6.1 Binding
Tested for affinity against NK-1(Neurokinin-1) receptor expressed as pKiTested for affinity against NK-1(Neurokinin-1) receptor expressed as pKi
ChEMBL 544 4 1 4 4.6 CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(=O)N1CC(=O)Nc2ccccc2C1CN1CCOCC1 10.1016/S0960-894X(97)00353-3
90417914 125643 0 None -2570 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 433 4 0 7 5.0 CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)co1 10.1021/jm5017413
CHEMBL3422015 125643 0 None -2570 5 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysisDisplacement of [3H]-Substance P from human NK1R after 90 mins by scintillation counting analysis
ChEMBL 433 4 0 7 5.0 CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)co1 10.1021/jm5017413
9887650 23423 0 None -6309 5 Human 5.1 pKi = 5.1 Binding
The compound was tested for binding affinity against Tachykinin receptor 1 from rabbit cortexThe compound was tested for binding affinity against Tachykinin receptor 1 from rabbit cortex
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL124208 23423 0 None -6309 5 Human 5.1 pKi = 5.1 Binding
The compound was tested for binding affinity against Tachykinin receptor 1 from rabbit cortexThe compound was tested for binding affinity against Tachykinin receptor 1 from rabbit cortex
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
44380794 127061 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 13 2 6 8.2 O=C(O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352614 127061 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 720 13 2 6 8.2 O=C(O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10078301 126010 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 12 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL343447 126010 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 681 12 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44364002 127826 0 None 8 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 627 11 1 5 6.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356796 127826 0 None 8 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 627 11 1 5 6.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
127033173 145622 0 None -2 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1062 16 7 9 5.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O 10.1021/acsmedchemlett.5b00359
CHEMBL3781519 145622 0 None -2 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1062 16 7 9 5.0 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CCC(=O)N2CCN([C@@H]3CCN(C(=O)c4cc(C(F)(F)F)cc(C(F)(F)F)c4)C[C@@H]3c3ccccc3)CC2)C1=O 10.1021/acsmedchemlett.5b00359
9872295 19394 1 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL1187084 19394 1 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL489924 19394 1 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 491 3 1 2 5.9 Cc1cc(F)ccc1[C@@H]1CNCCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
44334499 114077 0 None - 1 Human 8.1 pKi = 8.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 652 4 0 6 3.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)CN1CCOCC1 10.1016/s0960-894x(02)00659-5
CHEMBL317238 114077 0 None - 1 Human 8.1 pKi = 8.1 Binding
Affinity for human Tachykinin receptor 1 expressed in CHO cellsAffinity for human Tachykinin receptor 1 expressed in CHO cells
ChEMBL 652 4 0 6 3.7 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)C1C(=O)N(c3ccccc3)C(=O)C1CN2C(=O)CN1CCOCC1 10.1016/s0960-894x(02)00659-5
127032846 145569 0 None 4 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1081 24 9 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
CHEMBL3780818 145569 0 None 4 2 Human 8.1 pKi = 8.1 Binding
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysisAntagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
ChEMBL 1081 24 9 9 5.7 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)CC(=O)N1CC[C@@H](C(=O)N(C)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H](c2ccccc2)C1 10.1021/acsmedchemlett.5b00359
85169 13687 10 None -2 2 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL108438 13687 10 None -2 2 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 311 7 3 3 0.8 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
9846662 82687 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1ccncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
CHEMBL204958 82687 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 452 4 0 2 6.4 Cc1ccccc1-c1ccncc1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.11.047
3668 8342 42 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
5311081 8342 42 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL333357 8342 42 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
CHEMBL589982 8342 42 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None None 10.1021/jm901352b
3668 8342 42 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
5311081 8342 42 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
CHEMBL333357 8342 42 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
CHEMBL589982 8342 42 None -38 10 Rat 8.1 pKi = 8.1 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting methodDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membranes after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmcl.2018.06.009
10299289 199394 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 3 4.6 Cc1cc(F)ccc1N1CCNCC1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
CHEMBL521605 199394 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells
ChEMBL 477 4 1 3 4.6 Cc1cc(F)ccc1N1CCNCC1C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm900023b
10232846 120893 0 None 11 2 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL332793 120893 0 None 11 2 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Human Tachykinin receptor 1In vitro binding affinity towards Human Tachykinin receptor 1
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
10767720 85467 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 500 8 2 3 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)Nc1ccccc1 10.1021/jm970499g
CHEMBL2112476 85467 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 500 8 2 3 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=S)Nc1ccccc1 10.1021/jm970499g
73351579 96180 0 None -2 2 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 800 7 9 9 0.1 CC(C)=CCc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1O 10.1021/jm00029a007
CHEMBL2370507 96180 0 None -2 2 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL 800 7 9 9 0.1 CC(C)=CCc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1O 10.1021/jm00029a007
10792994 14286 0 None - 1 Human 5.1 pKi = 5.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 560 7 2 3 4.5 O=C(N[C@@H](Cc1ccccc1)C(=O)N1CCc2ccccc2C1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
CHEMBL108725 14286 0 None - 1 Human 5.1 pKi = 5.1 Binding
In vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1RIn vitro binding affinity towards Tachykinin receptor 1 by measuring its ability to displace [3H]SP (0.6 nM) binding to membranes from Cos-7 cells transiently transfected with the hNK-1R
ChEMBL 560 7 2 3 4.5 O=C(N[C@@H](Cc1ccccc1)C(=O)N1CCc2ccccc2C1)[C@@H]1CCCN1C(=S)NCc1ccccc1Cl 10.1021/jm970499g
44380763 126811 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 690 12 1 5 9.1 CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL350360 126811 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandBinding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL 690 12 1 5 9.1 CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44281476 106707 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 662 10 1 5 8.6 CO/N=C(\COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286235 106707 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 662 10 1 5 8.6 CO/N=C(\COc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44314533 112456 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 710 12 0 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312539 112456 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 710 12 0 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314946 211842 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 14 0 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C(C)C)C(C)C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77235 211842 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 726 14 0 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C(C)C)C(C)C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
1016 10519 78 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2561 10519 78 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2733526 10519 78 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5384 10519 78 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL83 10519 78 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
DB00675 10519 78 None -39 35 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2247 7293 81 None -117 42 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
249 7293 81 None -117 42 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2603 7293 81 None -117 42 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
CHEMBL296419 7293 81 None -117 42 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
DB00637 7293 81 None -117 42 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2812 11551 101 None -43 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 11551 101 None -43 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
44407932 82672 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
CHEMBL204918 82672 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 436 5 2 2 4.6 O=C1NC[C@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccc(F)cc2)N1 10.1016/j.bmcl.2005.10.072
9940831 21418 0 None 1 4 Human 8.1 pKi = 8.1 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1205204 21418 0 None 1 4 Human 8.1 pKi = 8.1 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL65468 21418 0 None 1 4 Human 8.1 pKi = 8.1 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
10032406 46728 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 667 11 0 5 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147824 46728 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards NK1 receptorBinding affinity towards NK1 receptor
ChEMBL 667 11 0 5 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314868 162477 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL405129 162477 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandBinding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314487 109690 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 753 13 1 7 6.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(NC(C)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306097 109690 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Inhibitory activity against human tachykinin receptor 1Inhibitory activity against human tachykinin receptor 1
ChEMBL 753 13 1 7 6.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(NC(C)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281672 120301 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 596 10 1 6 6.2 CO/N=C(\CN(C)C(=O)c1cc(C)nc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33215 120301 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 596 10 1 6 6.2 CO/N=C(\CN(C)C(=O)c1cc(C)nc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL387816 219191 0 None 23 2 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membraneDisplacement of [3H]SP1-7 from NK1 receptor in Sprague-Dawley rat spinal cord membrane
ChEMBL None None None C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm901352b
44611292 97839 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 2 3 1.1 CN(C(=O)[C@@H](N)Cc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
CHEMBL2397484 97839 0 None - 1 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 325 7 2 3 1.1 CN(C(=O)[C@@H](N)Cc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm400209h
44305818 21567 0 None 1 4 Human 8.0 pKi = 8.0 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1206764 21567 0 None 1 4 Human 8.0 pKi = 8.0 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL305119 21567 0 None 1 4 Human 8.0 pKi = 8.0 Binding
Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.Binding affinity for NK-1 receptor was determined in vitro using isolated rabbit vena cava.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL2419539 217219 0 None -81 4 Rat 8.0 pKi = 8.0 Binding
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cellsDisplacement of [3H]substance P from rat NK1 receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2013.06.065
44337173 13461 0 None -30 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 582 7 2 5 4.6 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ncc[nH]4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108350 13461 0 None -30 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 582 7 2 5 4.6 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ncc[nH]4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
122187725 129845 0 None -107 4 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 691 11 6 5 4.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
CHEMBL3609621 129845 0 None -107 4 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]-substance P from rat NK1 receptor transfected in CHO cellsDisplacement of [3H]-substance P from rat NK1 receptor transfected in CHO cells
ChEMBL 691 11 6 5 4.9 Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2015.06.030
44281358 105039 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 674 11 1 4 9.5 CO/N=C(\CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL274557 105039 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 674 11 1 4 9.5 CO/N=C(\CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44337266 12070 0 None -27 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 564 7 1 4 5.3 O=C(c1ccccc1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL106608 12070 0 None -27 2 Human 7.0 pKi = 7.0 Binding
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 1 in CHO cells by using [3H]-Sar SP as the radioligand.
ChEMBL 564 7 1 4 5.3 O=C(c1ccccc1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44407896 145439 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
CHEMBL377712 145439 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsDisplacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cells
ChEMBL 432 5 2 2 5.0 C[C@H](OC[C@@]1(c2ccccc2)CNC(=O)N1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2005.10.072
44408697 82206 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 409 4 1 3 6.8 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1c(Cl)cccc1Cl 10.1016/j.bmcl.2005.11.047
CHEMBL204165 82206 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 409 4 1 3 6.8 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1c(Cl)cccc1Cl 10.1016/j.bmcl.2005.11.047
73355028 97844 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@H]1[C@@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2397489 97844 0 None - 1 Rat 7.0 pKi = 7.0 Binding
Displacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysisDisplacement of [3H]SP1-7 from substance P receptor (1 to 7 amino acids) binding site in Sprague-Dawley rat spinal cord membranes after 60 mins by liquid scintillation counting analysis
ChEMBL 337 5 2 3 1.4 NC(=O)[C@H]1[C@@H](c2ccccc2)CCN1C(=O)[C@@H](N)Cc1ccccc1 10.1021/jm400209h
CHEMBL2111789 215998 0 None -3 2 Human 4.0 pKi = 4.0 Binding
Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)Displacement of [125I]- substance P binding to human astrocytoma cells (NK1)
ChEMBL None None None CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(OC(C)(C)C)cc2)NC(=O)CNC1=O 10.1021/jm00029a007
44408910 148070 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 341 4 1 3 5.5 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
CHEMBL383289 148070 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cellsDisplacement of [3H]-labeled substance P from cloned human NK1 receptor expressed in CHO cells
ChEMBL 341 4 1 3 5.5 Clc1cncc(Cl)c1N/N=C/c1ccccc1-c1ccccc1 10.1016/j.bmcl.2005.11.047
10409484 196440 1 None - 1 Human 4.0 pKi = 4.0 Binding
Displacement of [3H]substance P from NK1 receptor in human astrocytoma cellsDisplacement of [3H]substance P from NK1 receptor in human astrocytoma cells
ChEMBL 413 0 2 6 0.9 C[C@@]12NC(=O)[C@@H](C[C@@]13c1ccccc1N1C(=O)CN[C@@H]13)n1c2nc2ccccc2c1=O 10.1021/np50106a005
CHEMBL515179 196440 1 None - 1 Human 4.0 pKi = 4.0 Binding
Displacement of [3H]substance P from NK1 receptor in human astrocytoma cellsDisplacement of [3H]substance P from NK1 receptor in human astrocytoma cells
ChEMBL 413 0 2 6 0.9 C[C@@]12NC(=O)[C@@H](C[C@@]13c1ccccc1N1C(=O)CN[C@@H]13)n1c2nc2ccccc2c1=O 10.1021/np50106a005
44281753 106593 0 None -9 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 626 11 1 5 7.8 CO/N=C(\COCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285476 106593 0 None -9 2 Human 7.0 pKi = 7.0 Binding
Tested for binding affinity against neurokinin 1 (NK1) receptorTested for binding affinity against neurokinin 1 (NK1) receptor
ChEMBL 626 11 1 5 7.8 CO/N=C(\COCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
43815 193699 64 None - 25 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
Drug Central 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 None
CHEMBL1708 193699 64 None - 25 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
Drug Central 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 None
CHEMBL490 193699 64 None - 25 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisDisplacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysis
Drug Central 329 4 1 4 3.3 Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 None
132837 9018 55 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
9461 9018 55 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
CHEMBL22870 9018 55 None 18 5 Human 8.6 pIC50 = 8.6 Binding
Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.Antagonism of [<sup>125</sup>]-substance P binding, to NK<sub>1</sub> receptors expressed in CHO cells.
Guide to Pharmacology 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 7509807
9329 10513 5 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.
Guide to Pharmacology 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10508446
9894349 10513 5 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.
Guide to Pharmacology 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10508446
CHEMBL339486 10513 5 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.Inhibition of [<sup>125</sup>I]BH-SP binding in human IM-9 cells.
Guide to Pharmacology 573 3 0 4 7.1 C[C@@H]1CCn2c(C(=O)N(C1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c(c1ccc(cc1)C)c1c(c2=O)nccc1 10508446
23653789 10359 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.
Guide to Pharmacology 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 19354254
9280 10359 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.
Guide to Pharmacology 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 19354254
CHEMBL447955 10359 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.
Guide to Pharmacology 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 19354254
DB12973 10359 24 None - 2 Human 10.2 pIC50 = 10.2 Binding
Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.Inhibition of binding of <sup>125</sup>I-Substance P <i>in vitro</i>.
Guide to Pharmacology 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 19354254
2098 10466 36 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
36511 10466 36 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
3805 10466 36 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
3835 10466 36 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
CHEMBL235363 10466 36 None 1 6 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2410593
9278 10622 0 None - 1 Human 7.0 pKi < 7 Binding
Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)
Guide to Pharmacology 587 6 0 6 7.4 Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F None
9916461 10622 0 None - 1 Human 7.0 pKi < 7 Binding
Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)
Guide to Pharmacology 587 6 0 6 7.4 Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F None
CHEMBL3544984 10622 0 None - 1 Human 7.0 pKi < 7 Binding
Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)
Guide to Pharmacology 587 6 0 6 7.4 Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F None
DB12580 10622 0 None - 1 Human 7.0 pKi < 7 Binding
Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)Measuring displacement of [125I]-substance P binding to membranes from IM-9 cells (human B lymphocytes)
Guide to Pharmacology 587 6 0 6 7.4 Clc1ccccc1C(=O)c1cccnc1c1nnn(c1c1ccncc1)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F None
2098 10466 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 10466 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 10466 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 10466 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 10466 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 10466 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 10466 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 10466 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 10466 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 10466 36 125I-Bolton Hunter 1 6 Human 10.4 pKi = 10.4 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 10466 36 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 10466 36 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 10466 36 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 10466 36 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 10466 36 125I-Bolton Hunter -1 6 Rat 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 10466 36 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 10466 36 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 10466 36 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 10466 36 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 10466 36 125I-Bolton Hunter -2 6 Guinea pig 10.2 pKi = 10.2 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 10466 36 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 10466 36 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 10466 36 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 10466 36 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 10466 36 125I-Bolton Hunter 1 6 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 10466 36 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 10466 36 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 10466 36 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 10466 36 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 10466 36 125I-Bolton Hunter -2 6 Guinea pig 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 10466 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 10466 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 10466 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 10466 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 10466 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 10466 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 10466 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 10466 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 10466 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 10466 36 125I-Bolton Hunter 1 6 Human 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None None None
2098 10466 36 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 10466 36 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 10466 36 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 10466 36 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 10466 36 125I-Bolton Hunter -1 6 Rat 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase None None None None None
None 222966 0 125I-Bolton Hunter 2 5 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 588 8 2 5 4.3 CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O None
135413536 7236 85 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
230 7236 85 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
3490 7236 85 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
6918365 7236 85 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
CHEMBL1471 7236 85 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
DB00673 7236 85 None 50 2 Human 8.0 pKi = 8.0 Binding
GRAC: human NK1 selective antagonistGRAC: human NK1 selective antagonist
Drug Central 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C None
202 8290 77 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
60835 8290 77 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
972 8290 77 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
CHEMBL1175 8290 77 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
DB00476 8290 77 UNDEFINED -9 33 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
5656 209845 87 UNDEFINED -7 43 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
CHEMBL637 209845 87 UNDEFINED -7 43 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
54841 209906 52 UNDEFINED -1 30 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
CHEMBL641 209906 52 UNDEFINED -1 30 Rat 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
3075702 224111 0 3H-SP -2 37 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 198 3 1 3 1.5 C1CNC1COC2=CN=C(C=C2)Cl None
119376 8622 48 3H-SUBSTANCE P -54954 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
247 8622 48 3H-SUBSTANCE P -54954 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
CHEMBL33884 8622 48 3H-SUBSTANCE P -54954 27 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
3294 8787 111 3H-Sar9SP -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 8787 111 3H-Sar9SP -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 8787 111 3H-Sar9SP -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 8787 111 3H-Sar9SP -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 8787 111 3H-Sar9SP -14454 44 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
243 9976 91 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3052762 9976 91 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3502 9976 91 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
CHEMBL117287 9976 91 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
DB06480 9976 91 3H-SUBSTANCE P -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
21830793 98610 10 3H-8-OH-DPAT -66069 46 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 None
CHEMBL2413154 98610 10 3H-8-OH-DPAT -66069 46 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 None
133090 105199 20 125I-[MePhe7]-NKB -630 3 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 5 2 3 5.5 CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 None
CHEMBL275544 105199 20 125I-[MePhe7]-NKB -630 3 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 5 2 3 5.5 CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 None
44208932 147485 7 UNDEFINED -89125 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
CHEMBL381689 147485 7 UNDEFINED -89125 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
1973 210262 15 125I-[SAR9, Met(O2)11]-SP -3 36 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL1394464 210262 15 125I-[SAR9, Met(O2)11]-SP -3 36 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL66089 210262 15 125I-[SAR9, Met(O2)11]-SP -3 36 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
5079497 222853 0 125I-[MePhe7]-NKB -1445 3 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 841 26 8 10 -0.0 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(CC1=CC=CC=C1)N(C)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)CCC(=O)O None
None 222907 0 3H-Leu,4,5 Substance P -1 13 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 164 3 1 3 0.8 C1CNC1COC2=CN=CC=C2 None
119380 222908 0 3H-Leu,4,5 Substance P -1 8 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 166 1 0 3 1.8 CC1=NOC(=C1)C2CCCN2C None
None 223272 0 3H-SUBSTANCE P -10471285 17 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 372 2 1 3 4.4 CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl None
None 222854 0 125I-Bolton Hunter -354 8 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 222854 0 3H-SUBSTANCE P -354 8 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 222854 0 125I-Bolton Hunter -354 8 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
2098 10466 36 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
36511 10466 36 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
3805 10466 36 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
3835 10466 36 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL235363 10466 36 125I-[MePhe7]-NKB 1 6 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase None None None None None
None 222854 0 125I-Bolton Hunter -1202 8 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 222966 0 125I-Bolton Hunter -1412 5 Rat 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 588 8 2 5 4.3 CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O None
None 222967 0 125I-Bolton Hunter -2 6 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 1041 17 10 13 0.9 CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C None
9850582 204021 22 125I-Bolton Hunter -309 6 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 204021 22 125I-Bolton Hunter -309 6 Guinea pig 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
None 222854 0 125I-Bolton Hunter -354 8 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 222967 0 125I-Bolton Hunter -2 6 Rat 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 1041 17 10 13 0.9 CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C None
9850582 204021 22 3H-Sar9,Met(O2)11-Substance P -588 6 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 204021 22 3H-Sar9,Met(O2)11-Substance P -588 6 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
None 222854 0 3H-Sar9,Met(O2)11-Substance P -354 8 Human 6.5 pKi = 6.5 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 222966 0 125I-Bolton Hunter -2 5 Guinea pig 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 588 8 2 5 4.3 CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O None
None 222854 0 125I-Bolton Hunter -354 8 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 222854 0 125I-Bolton Hunter -354 8 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
9850582 204021 22 125I-[MePhe7]-NKB -588 6 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 204021 22 125I-[MePhe7]-NKB -588 6 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
2812 11551 101 None -43 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 None
CHEMBL104 11551 101 None -43 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 None
2247 7293 81 None -117 42 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
249 7293 81 None -117 42 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
2603 7293 81 None -117 42 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
CHEMBL296419 7293 81 None -117 42 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
DB00637 7293 81 None -117 42 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 None
1016 10519 78 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
2561 10519 78 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
2733526 10519 78 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
5384 10519 78 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
CHEMBL83 10519 78 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
DB00675 10519 78 None -39 35 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
3198 212292 76 None -37 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL1201049 212292 76 None -37 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
CHEMBL808 212292 76 None -37 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 None
4189 213701 96 None -27 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL1559 213701 96 None -27 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL91 213701 96 None -27 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
None 222851 0 125I-[MePhe7]-NKB -676 4 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 1210 38 14 16 -1.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)N None
9850582 204021 22 125I-Bolton Hunter -588 6 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
CHEMBL56835 204021 22 125I-Bolton Hunter -588 6 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 None
None 222854 0 125I-Bolton Hunter -354 8 Human 7.2 pKi = 7.2 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
None 222852 0 125I-[MePhe7]-NKB -851 6 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 1133 37 16 17 -4.6 CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N None
None 222854 0 125I-[MePhe7]-NKB -354 8 Human 6.1 pKi = 6.1 Binding
NoneNone
PDSP KiDatabase 605 8 0 3 7.4 CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5 None
4898 9541 86 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
5742 9541 86 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
6451149 9541 86 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
CHEMBL206253 9541 86 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
DB09048 9541 86 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C None
71544786 224528 0 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 689 8 2 5 6.4 CN(C(=O)C(C)(C)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)C1=CN=C(C=C1C1=C(C)C=CC=C1)N1CC[N+](C)(COP(O)(O)=O)CC1 None
71544787 224528 0 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 689 8 2 5 6.4 CN(C(=O)C(C)(C)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)C1=CN=C(C=C1C1=C(C)C=CC=C1)N1CC[N+](C)(COP(O)(O)=O)CC1 None
CHEMBL3989917 224528 0 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 689 8 2 5 6.4 CN(C(=O)C(C)(C)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)C1=CN=C(C=C1C1=C(C)C=CC=C1)N1CC[N+](C)(COP(O)(O)=O)CC1 None
DB14019 224528 0 None - 1 Human 8.0 pKi = 8.0 Binding
displacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cellsdisplacement of [3H]-labelled substance P from cloned human receptor expressed in CHO cells
Drug Central 689 8 2 5 6.4 CN(C(=O)C(C)(C)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)C1=CN=C(C=C1C1=C(C)C=CC=C1)N1CC[N+](C)(COP(O)(O)=O)CC1 None
10311306 10140 52 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
5027 10140 52 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
5749 10140 52 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
CHEMBL3707331 10140 52 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
DB09291 10140 52 None - 1 Human 8.0 pKi = 8.0 Binding
CHO cells expressing the human NK1 receptorCHO cells expressing the human NK1 receptor
Drug Central 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 None
23725089 7591 13 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
4401 7591 13 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
5758 7591 13 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
9917021 7591 13 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
CHEMBL1672054 7591 13 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
DB06634 7591 13 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation countingDisplacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting
Drug Central 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C None
None 222967 0 125I-Bolton Hunter 2 6 Guinea pig 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 1041 17 10 13 0.9 CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C None
135413536 7236 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
135413536 7236 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
230 7236 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
230 7236 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
3490 7236 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
3490 7236 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
6918365 7236 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
6918365 7236 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
CHEMBL1471 7236 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
CHEMBL1471 7236 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
DB00673 7236 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 10737756
DB00673 7236 85 None 50 2 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 534 6 2 5 5.0 Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH][nH]c(=O)n1)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 9804700
10158788 10500 0 None - 1 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 415 6 2 4 5.0 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)c1ccc(cc1F)C#N 18187929
5746 10500 0 None - 1 Human 10.1 pKi = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 415 6 2 4 5.0 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)c1ccc(cc1F)C#N 18187929
5752 10777 24 None - 1 Human 10.6 pKi = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 8876035
6918331 10777 24 None - 1 Human 10.6 pKi = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 8876035
CHEMBL522302 10777 24 None - 1 Human 10.6 pKi = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 8876035
DB12436 10777 24 None - 1 Human 10.6 pKi = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 6 2 7 3.3 COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)n1nnnc1C(F)(F)F 8876035
2087 8701 0 None 31 4 Human 10.8 pKi = 10.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
119137 10357 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
119137 10357 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
2095 10357 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
2095 10357 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
CHEMBL1885865 10357 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
CHEMBL1885865 10357 0 None - 1 Human 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
5759 7381 24 None - 1 Human 9.0 pKi = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 16332435
6450815 7381 24 None - 1 Human 9.0 pKi = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 16332435
CHEMBL204694 7381 24 None - 1 Human 9.0 pKi = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 565 5 0 4 6.9 O=C(C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)N(c1cnc(cc1c1ccccc1C)N1CCOCC1)C 16332435
4898 9541 86 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
5742 9541 86 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
6451149 9541 86 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
CHEMBL206253 9541 86 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
DB09048 9541 86 None - 1 Human 9.0 pKi = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 5 0 4 6.8 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C 16332435
107967 8427 0 None 1000 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 588 8 2 5 4.3 O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 8630576
2114 8427 0 None 1000 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 588 8 2 5 4.3 O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 8630576
CHEMBL1416993 8427 0 None 1000 2 Human 9.1 pKi = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 588 8 2 5 4.3 O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2 8630576
10311306 10140 52 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
5027 10140 52 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
5749 10140 52 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
CHEMBL3707331 10140 52 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
DB09291 10140 52 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 500 5 2 3 5.7 O=C1CC[C@@]2(N1)CC[C@@](NC2)(CO[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccccc1 22497992
10462 8797 10 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 16332435
9808518 8797 10 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 16332435
CHEMBL206488 8797 10 None - 1 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 550 5 0 4 6.1 CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)C(=O)N(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C 16332435
5754 10040 0 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 660 7 1 4 6.8 O=C(Nc1c(C)cccc1C)CN1CCN(CC1)[C@H]1CCN([C@@H](C1)Cc1ccccc1)C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F 12130734
9917716 10040 0 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 660 7 1 4 6.8 O=C(Nc1c(C)cccc1C)CN1CCN(CC1)[C@H]1CCN([C@@H](C1)Cc1ccccc1)C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F 12130734
5757 10758 12 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 18657401
5757 10758 12 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 19388677
9832383 10758 12 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 18657401
9832383 10758 12 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 19388677
CHEMBL522987 10758 12 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 18657401
CHEMBL522987 10758 12 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 19388677
DB11949 10758 12 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 18657401
DB11949 10758 12 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 491 3 1 2 5.9 Fc1ccc(c(c1)C)[C@H]1CNCCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C 19388677
23725089 7591 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
23725089 7591 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
4401 7591 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
4401 7591 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
5758 7591 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
5758 7591 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
9917021 7591 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
9917021 7591 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
CHEMBL1672054 7591 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
CHEMBL1672054 7591 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
DB06634 7591 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 20533894
DB06634 7591 13 None - 1 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 616 4 0 3 6.7 Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCN(CC1)C(=O)C 24106886
2102 7972 21 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 12206858
2102 7972 21 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 9190866
5311057 7972 21 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 12206858
5311057 7972 21 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 9190866
CHEMBL441225 7972 21 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 12206858
CHEMBL441225 7972 21 None -2 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 296 5 2 3 3.3 COc1ccccc1CN[C@H]1CCCN[C@H]1c1ccccc1 9190866
188927 8396 0 None - 1 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 454 8 1 3 6.2 COc1ccc(cc1CN[C@H]1C2CCN([C@H]1C(c1ccccc1)c1ccccc1)CC2)C(C)C 12372904
5751 8396 0 None - 1 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 454 8 1 3 6.2 COc1ccc(cc1CN[C@H]1C2CCN([C@H]1C(c1ccccc1)c1ccccc1)CC2)C(C)C 12372904
CHEMBL515966 8396 0 None - 1 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 454 8 1 3 6.2 COc1ccc(cc1CN[C@H]1C2CCN([C@H]1C(c1ccccc1)c1ccccc1)CC2)C(C)C 12372904
3086681 9052 17 None 89125 3 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 7473161
3510 9052 17 None 89125 3 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 7473161
CHEMBL42407 9052 17 None 89125 3 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 7473161
2090 9543 25 None -309 4 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
5311312 9543 25 None -309 4 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
CHEMBL437797 9543 25 None -309 4 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
2110 9743 38 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
219077 9743 38 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
3480 9743 38 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
CHEMBL346178 9743 38 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
DB04872 9743 38 None -1258 6 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 12206858
104974 10248 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
104974 10248 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
2111 10248 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
2111 10248 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
3481 10248 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
3481 10248 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
CHEMBL308148 10248 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
CHEMBL308148 10248 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
DB06660 10248 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 12206858
DB06660 10248 31 None -1202 7 Human 6.4 pKi None 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 9190866
2105 10050 0 None - 1 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12206858
2089 9542 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
2089 9542 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311270
2089 9542 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
2089 9542 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
3795 9542 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
3795 9542 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311270
3795 9542 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
3795 9542 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
5311311 9542 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
5311311 9542 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311270
5311311 9542 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
5311311 9542 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
CHEMBL217406 9542 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
CHEMBL217406 9542 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311270
CHEMBL217406 9542 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8985159
CHEMBL217406 9542 28 None -102 5 Human 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9190866
2106 10319 4 None -5 3 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 12206858
9875034 10319 4 None -5 3 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 12206858
CHEMBL77023 10319 4 None -5 3 Human 8.6 pKi None 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 12206858
2098 10466 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
2098 10466 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501
36511 10466 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
36511 10466 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501
3805 10466 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
3805 10466 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501
3835 10466 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
3835 10466 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501
CHEMBL235363 10466 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11786503
CHEMBL235363 10466 36 None 1 6 Human 9.4 pKi None 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15265501