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Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	5280878	100327	None	24	Human	Functional	pEC50	=	9.1	9.1	2	2	Agonist activity at human CysLT1 receptorAgonist activity at human CysLT1 receptor	ChEMBL	496	20	5	6	3.4	CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O	10.1021/acs.jmedchem.1c01078
	CHEMBL288943	100327	None	24	Human	Functional	pEC50	=	9.1	9.1	2	2	Agonist activity at human CysLT1 receptorAgonist activity at human CysLT1 receptor	ChEMBL	496	20	5	6	3.4	CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O	10.1021/acs.jmedchem.1c01078
	3352	2371	None	24	Human	Functional	pEC50	=	7.0	7.0	-575	4	Agonist activity at human CysLT1 receptorAgonist activity at human CysLT1 receptor	ChEMBL	439	18	4	5	4.3	CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N	10.1021/acs.jmedchem.1c01078
	5280879	2371	None	24	Human	Functional	pEC50	=	7.0	7.0	-575	4	Agonist activity at human CysLT1 receptorAgonist activity at human CysLT1 receptor	ChEMBL	439	18	4	5	4.3	CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N	10.1021/acs.jmedchem.1c01078
	5863	2371	None	24	Human	Functional	pEC50	=	7.0	7.0	-575	4	Agonist activity at human CysLT1 receptorAgonist activity at human CysLT1 receptor	ChEMBL	439	18	4	5	4.3	CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N	10.1021/acs.jmedchem.1c01078
	CHEMBL509456	2371	None	24	Human	Functional	pEC50	=	7.0	7.0	-575	4	Agonist activity at human CysLT1 receptorAgonist activity at human CysLT1 receptor	ChEMBL	439	18	4	5	4.3	CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N	10.1021/acs.jmedchem.1c01078
	49863644	15319	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	498	13	1	5	6.1	O=C(O)COc1ccc(F)cc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1	10.1016/j.bmc.2010.06.047
	CHEMBL1213847	15319	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	498	13	1	5	6.1	O=C(O)COc1ccc(F)cc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1	10.1016/j.bmc.2010.06.047
	49863643	15318	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	480	13	1	5	5.9	O=C(O)COc1ccccc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1	10.1016/j.bmc.2010.06.047
	CHEMBL1213846	15318	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	480	13	1	5	5.9	O=C(O)COc1ccccc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1	10.1016/j.bmc.2010.06.047
	49863685	15323	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	471	13	1	6	5.4	N#CCOc1ccc(C(=O)O)cc1C(=O)/C=C/c1ccc(OCCCCOc2ccccc2)cc1	10.1016/j.bmc.2010.06.047
	CHEMBL1213918	15323	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	471	13	1	6	5.4	N#CCOc1ccc(C(=O)O)cc1C(=O)/C=C/c1ccc(OCCCCOc2ccccc2)cc1	10.1016/j.bmc.2010.06.047
	3354	2369	None	23	Human	Functional	pEC50	=	7.4	7.4	-74	4	Agonist activity at human CysLT1 receptorAgonist activity at human CysLT1 receptor	ChEMBL	625	25	7	8	2.8	CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N	10.1021/acs.jmedchem.1c01078
	5280493	2369	None	23	Human	Functional	pEC50	=	7.4	7.4	-74	4	Agonist activity at human CysLT1 receptorAgonist activity at human CysLT1 receptor	ChEMBL	625	25	7	8	2.8	CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N	10.1021/acs.jmedchem.1c01078
	CHEMBL451509	2369	None	23	Human	Functional	pEC50	=	7.4	7.4	-74	4	Agonist activity at human CysLT1 receptorAgonist activity at human CysLT1 receptor	ChEMBL	625	25	7	8	2.8	CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N	10.1021/acs.jmedchem.1c01078
	DB08855	2369	None	23	Human	Functional	pEC50	=	7.4	7.4	-74	4	Agonist activity at human CysLT1 receptorAgonist activity at human CysLT1 receptor	ChEMBL	625	25	7	8	2.8	CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N	10.1021/acs.jmedchem.1c01078
	46919026	15322	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	505	13	1	6	6.1	N#CCOc1cc(C(=O)O)ccc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1	10.1016/j.bmc.2010.06.047
	CHEMBL1213917	15322	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	505	13	1	6	6.1	N#CCOc1cc(C(=O)O)ccc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1	10.1016/j.bmc.2010.06.047
	1836	2592	None	44	Human	Functional	pEC50	=	7.1	7.1	-10	20	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	10.1016/j.bmc.2010.06.047
	3340	2592	None	44	Human	Functional	pEC50	=	7.1	7.1	-10	20	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	10.1016/j.bmc.2010.06.047
	5281040	2592	None	44	Human	Functional	pEC50	=	7.1	7.1	-10	20	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	10.1016/j.bmc.2010.06.047
	5281040.0	2592	None	44	Human	Functional	pEC50	=	7.1	7.1	-10	20	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	10.1016/j.bmc.2010.06.047
	CHEMBL787	2592	None	44	Human	Functional	pEC50	=	7.1	7.1	-10	20	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	10.1016/j.bmc.2010.06.047
	DB00471	2592	None	44	Human	Functional	pEC50	=	7.1	7.1	-10	20	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	10.1016/j.bmc.2010.06.047
	9829145	119391	None	0	Human	Functional	pIC50	=	9.7	9.7	-	1	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	555	12	2	4	8.0	CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCC3)c1	10.1016/j.bmc.2010.06.047
	CHEMBL344180	119391	None	0	Human	Functional	pIC50	=	9.7	9.7	-	1	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	555	12	2	4	8.0	CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCC3)c1	10.1016/j.bmc.2010.06.047
	44360643	30896	None	0	Human	Functional	pIC50	=	9.7	9.7	-	1	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	559	12	2	5	7.9	CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CSC3)c1	10.1016/j.bmc.2010.06.047
	CHEMBL139757	30896	None	0	Human	Functional	pIC50	=	9.7	9.7	-	1	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	559	12	2	5	7.9	CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CSC3)c1	10.1016/j.bmc.2010.06.047
	122183753	122280	None	0	Human	Functional	pIC50	=	9.7	9.7	3	2	Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assayAntagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assay	ChEMBL	571	12	2	4	7.2	Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1	10.1021/acs.jmedchem.5b00741
	CHEMBL3597618	122280	None	0	Human	Functional	pIC50	=	9.7	9.7	3	2	Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assayAntagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assay	ChEMBL	571	12	2	4	7.2	Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1	10.1021/acs.jmedchem.5b00741
	2855	4132	None	63	Human	Functional	pIC50	=	9.6	9.6	1	12	Antagonist activity at human CysLT1 receptorAntagonist activity at human CysLT1 receptor	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1021/acs.jmedchem.1c01078
	3322	4132	None	63	Human	Functional	pIC50	=	9.6	9.6	1	12	Antagonist activity at human CysLT1 receptorAntagonist activity at human CysLT1 receptor	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1021/acs.jmedchem.1c01078
	5717	4132	None	63	Human	Functional	pIC50	=	9.6	9.6	1	12	Antagonist activity at human CysLT1 receptorAntagonist activity at human CysLT1 receptor	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1021/acs.jmedchem.1c01078
	5717.0	4132	None	63	Human	Functional	pIC50	=	9.6	9.6	1	12	Antagonist activity at human CysLT1 receptorAntagonist activity at human CysLT1 receptor	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1021/acs.jmedchem.1c01078
	CHEMBL603	4132	None	63	Human	Functional	pIC50	=	9.6	9.6	1	12	Antagonist activity at human CysLT1 receptorAntagonist activity at human CysLT1 receptor	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1021/acs.jmedchem.1c01078
	DB00549	4132	None	63	Human	Functional	pIC50	=	9.6	9.6	1	12	Antagonist activity at human CysLT1 receptorAntagonist activity at human CysLT1 receptor	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1021/acs.jmedchem.1c01078
	122183752	122279	None	0	Human	Functional	pIC50	=	9.5	9.5	17	2	Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assayAntagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assay	ChEMBL	557	11	2	4	6.8	Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CC(=O)O)c23)cc1	10.1021/acs.jmedchem.5b00741
	CHEMBL3597617	122279	None	0	Human	Functional	pIC50	=	9.5	9.5	17	2	Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assayAntagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assay	ChEMBL	557	11	2	4	6.8	Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CC(=O)O)c23)cc1	10.1021/acs.jmedchem.5b00741
	44360674	118635	None	0	Human	Functional	pIC50	=	9.5	9.5	-	1	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	569	12	2	4	8.3	CC1(C)Cc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1	10.1016/j.bmc.2010.06.047
	CHEMBL341603	118635	None	0	Human	Functional	pIC50	=	9.5	9.5	-	1	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	569	12	2	4	8.3	CC1(C)Cc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1	10.1016/j.bmc.2010.06.047
	122183751	122278	None	0	Human	Functional	pIC50	=	9.3	9.3	1	2	Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assayAntagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assay	ChEMBL	543	10	2	4	6.4	Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CC(=O)O)c23)cc1	10.1021/acs.jmedchem.5b00741
	CHEMBL3597616	122278	None	0	Human	Functional	pIC50	=	9.3	9.3	1	2	Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assayAntagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assay	ChEMBL	543	10	2	4	6.4	Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CC(=O)O)c23)cc1	10.1021/acs.jmedchem.5b00741
	15291446	35203	None	0	Human	Functional	pIC50	=	9.3	9.3	-	1	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	541	12	2	4	7.6	CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCC3)c1	10.1016/j.bmc.2010.06.047
	CHEMBL143515	35203	None	0	Human	Functional	pIC50	=	9.3	9.3	-	1	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	541	12	2	4	7.6	CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCC3)c1	10.1016/j.bmc.2010.06.047
	44360585	119156	None	0	Human	Functional	pIC50	=	9.3	9.3	-	1	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	569	12	2	4	8.6	CC1CCCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21	10.1016/j.bmc.2010.06.047
	CHEMBL342705	119156	None	0	Human	Functional	pIC50	=	9.3	9.3	-	1	Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challengeAntagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before LTD4 challenge	ChEMBL	569	12	2	4	8.6	CC1CCCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21	10.1016/j.bmc.2010.06.047
	66739117	122260	None	0	Human	Functional	pIC50	=	9.3	9.3	9	2	Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assayAntagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assay	ChEMBL	573	14	2	4	8.0	Cc1c(Cl)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1	10.1021/acs.jmedchem.5b00741
	CHEMBL3597535	122260	None	0	Human	Functional	pIC50	=	9.3	9.3	9	2	Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assayAntagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins prior to LTD4 addition measured after 1 hr by Fura 2-AM dye-based fluorescence assay	ChEMBL	573	14	2	4	8.0	Cc1c(Cl)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1	10.1021/acs.jmedchem.5b00741
	11261220	117982	None	0	Human	Functional	pIC50	=	9.2	9.2	5	2	Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assayAntagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay	ChEMBL	539	13	2	7	5.6	O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21	10.1016/j.bmc.2015.03.011
	CHEMBL3403186	117982	None	0	Human	Functional	pIC50	=	9.2	9.2	5	2	Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assayAntagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay	ChEMBL	539	13	2	7	5.6	O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21	10.1016/j.bmc.2015.03.011

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	2237	3162	None	53	Guinea pig	Binding	pIC50	=	10.4	10.4	4	3	Displacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting methodDisplacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting method	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1021/acs.jmedchem.6b01287
	3634	3162	None	53	Guinea pig	Binding	pIC50	=	10.4	10.4	4	3	Displacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting methodDisplacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting method	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1021/acs.jmedchem.6b01287
	4887	3162	None	53	Guinea pig	Binding	pIC50	=	10.4	10.4	4	3	Displacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting methodDisplacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting method	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1021/acs.jmedchem.6b01287
	4887.0	3162	None	53	Guinea pig	Binding	pIC50	=	10.4	10.4	4	3	Displacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting methodDisplacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting method	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1021/acs.jmedchem.6b01287
	CHEMBL21333	3162	None	53	Guinea pig	Binding	pIC50	=	10.4	10.4	4	3	Displacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting methodDisplacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting method	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1021/acs.jmedchem.6b01287
	DB01411	3162	None	53	Guinea pig	Binding	pIC50	=	10.4	10.4	4	3	Displacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting methodDisplacement of [3H]ICI from cysteinyl leukotriene receptor 1 in Hartley guinea pig lung membrane after 30 mins by liquid scintillation counting method	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1021/acs.jmedchem.6b01287
	15236851	112862	None	0	Guinea pig	Binding	pIC50	=	9.7	9.7	-	0	Concentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranesConcentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranes	ChEMBL	573	12	2	4	8.8	CC[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O	10.1016/0960-894X(95)00023-M
	CHEMBL330649	112862	None	0	Guinea pig	Binding	pIC50	=	9.7	9.7	-	0	Concentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranesConcentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranes	ChEMBL	573	12	2	4	8.8	CC[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O	10.1016/0960-894X(95)00023-M
	22848867	14766	None	0	Guinea pig	Binding	pIC50	=	9.7	9.7	-	1	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1	ChEMBL	563	12	2	5	7.8	C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O	10.1016/S0960-894X(00)80635-6
	CHEMBL1206453	14766	None	0	Guinea pig	Binding	pIC50	=	9.7	9.7	-	1	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1	ChEMBL	563	12	2	5	7.8	C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O	10.1016/S0960-894X(00)80635-6
	CHEMBL275357	14766	None	0	Guinea pig	Binding	pIC50	=	9.7	9.7	-	1	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1	ChEMBL	563	12	2	5	7.8	C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O	10.1016/S0960-894X(00)80635-6
	9829145	119391	None	0	Human	Binding	pIC50	=	9.6	9.6	-	0	In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesIn vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranes	ChEMBL	555	12	2	4	8.0	CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCC3)c1	10.1016/s0960-894x(98)00051-1
	CHEMBL344180	119391	None	0	Human	Binding	pIC50	=	9.6	9.6	-	0	In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesIn vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranes	ChEMBL	555	12	2	4	8.0	CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCC3)c1	10.1016/s0960-894x(98)00051-1
	44329532	210101	None	0	Guinea pig	Binding	pIC50	=	9.5	9.5	-	0	Concentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranesConcentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranes	ChEMBL	573	11	2	4	8.8	C[C@@H](S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)[C@H](C)C(=O)O	10.1016/0960-894X(95)00023-M
	CHEMBL95234	210101	None	0	Guinea pig	Binding	pIC50	=	9.5	9.5	-	0	Concentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranesConcentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranes	ChEMBL	573	11	2	4	8.8	C[C@@H](S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)[C@H](C)C(=O)O	10.1016/0960-894X(95)00023-M
	10099896	210872	None	11	Guinea pig	Binding	pIC50	=	9.5	9.5	-	0	Concentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranesConcentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranes	ChEMBL	587	12	2	4	9.2	CC(C)(CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O	10.1016/0960-894X(95)00023-M
	CHEMBL99775	210872	None	11	Guinea pig	Binding	pIC50	=	9.5	9.5	-	0	Concentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranesConcentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranes	ChEMBL	587	12	2	4	9.2	CC(C)(CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O	10.1016/0960-894X(95)00023-M
	10074173	16614	None	0	Guinea pig	Binding	pIC50	=	9.5	9.5	-	0	In vitro inhibition of [3H]LTD4 binding to guinea pig lung membranesIn vitro inhibition of [3H]LTD4 binding to guinea pig lung membranes	ChEMBL	486	11	2	5	5.9	NC(=O)CCSC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1	10.1021/jm00099a011
	CHEMBL124095	16614	None	0	Guinea pig	Binding	pIC50	=	9.5	9.5	-	0	In vitro inhibition of [3H]LTD4 binding to guinea pig lung membranesIn vitro inhibition of [3H]LTD4 binding to guinea pig lung membranes	ChEMBL	486	11	2	5	5.9	NC(=O)CCSC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1	10.1021/jm00099a011
	22848867	14766	None	0	Guinea pig	Binding	pIC50	=	9.5	9.5	-	1	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 2Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 2	ChEMBL	563	12	2	5	7.8	C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O	10.1016/S0960-894X(00)80635-6
	CHEMBL1206453	14766	None	0	Guinea pig	Binding	pIC50	=	9.5	9.5	-	1	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 2Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 2	ChEMBL	563	12	2	5	7.8	C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O	10.1016/S0960-894X(00)80635-6
	CHEMBL275357	14766	None	0	Guinea pig	Binding	pIC50	=	9.5	9.5	-	1	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 2Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 2	ChEMBL	563	12	2	5	7.8	C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O	10.1016/S0960-894X(00)80635-6
	15859376	210404	None	0	Guinea pig	Binding	pIC50	=	9.5	9.5	-	0	Concentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranesConcentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranes	ChEMBL	559	11	2	4	8.6	C[C@@H](CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1	10.1016/0960-894X(95)00023-M
	CHEMBL96986	210404	None	0	Guinea pig	Binding	pIC50	=	9.5	9.5	-	0	Concentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranesConcentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranes	ChEMBL	559	11	2	4	8.6	C[C@@H](CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1	10.1016/0960-894X(95)00023-M
	44269827	14601	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determinedInhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined	ChEMBL	558	12	2	6	7.1	O=C(O)CCSC(CCc1ccccc1-c1nc[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1	10.1016/S0960-894X(00)80635-6
	CHEMBL1204691	14601	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determinedInhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined	ChEMBL	558	12	2	6	7.1	O=C(O)CCSC(CCc1ccccc1-c1nc[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1	10.1016/S0960-894X(00)80635-6
	CHEMBL14819	14601	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determinedInhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined	ChEMBL	558	12	2	6	7.1	O=C(O)CCSC(CCc1ccccc1-c1nc[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1	10.1016/S0960-894X(00)80635-6
	44320022	106050	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Inhibition of binding of [ H]-LTD4 to DMSO differentiated U937 cell membranesInhibition of binding of [ H]-LTD4 to DMSO differentiated U937 cell membranes	ChEMBL	625	12	2	5	9.7	CC(C)(O)c1ccc(CC[C@@H](SCC2(CC(=O)O)CC2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)cc1	10.1016/0960-894X(95)00448-3
	CHEMBL313187	106050	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	Inhibition of binding of [ H]-LTD4 to DMSO differentiated U937 cell membranesInhibition of binding of [ H]-LTD4 to DMSO differentiated U937 cell membranes	ChEMBL	625	12	2	5	9.7	CC(C)(O)c1ccc(CC[C@@H](SCC2(CC(=O)O)CC2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)cc1	10.1016/0960-894X(95)00448-3
	15872197	207771	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Binding affinity against leukotriene D4 receptor in [3H]LTD4 binding assayBinding affinity against leukotriene D4 receptor in [3H]LTD4 binding assay	ChEMBL	632	8	2	8	5.7	COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(C)C)c2ccc(NC(=O)OC3CCCC3)cc12	10.1016/s0960-894x(98)00442-9
	CHEMBL79366	207771	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Binding affinity against leukotriene D4 receptor in [3H]LTD4 binding assayBinding affinity against leukotriene D4 receptor in [3H]LTD4 binding assay	ChEMBL	632	8	2	8	5.7	COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(C)C)c2ccc(NC(=O)OC3CCCC3)cc12	10.1016/s0960-894x(98)00442-9
	44213972	207839	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Binding affinity against leukotriene D4 receptor in [3H]LTD4 binding assayBinding affinity against leukotriene D4 receptor in [3H]LTD4 binding assay	ChEMBL	694	9	2	8	7.3	COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(C)c2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12	10.1016/s0960-894x(98)00442-9
	CHEMBL79952	207839	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Binding affinity against leukotriene D4 receptor in [3H]LTD4 binding assayBinding affinity against leukotriene D4 receptor in [3H]LTD4 binding assay	ChEMBL	694	9	2	8	7.3	COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(C)c2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12	10.1016/s0960-894x(98)00442-9
	44461050	208255	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Binding affinity against leukotriene D4 receptor in [3H]LTD4 binding assayBinding affinity against leukotriene D4 receptor in [3H]LTD4 binding assay	ChEMBL	674	8	2	9	5.5	COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N2CCOCC2)c2ccc(NC(=O)OC3CCCC3)cc12	10.1016/s0960-894x(98)00442-9
	CHEMBL83166	208255	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Binding affinity against leukotriene D4 receptor in [3H]LTD4 binding assayBinding affinity against leukotriene D4 receptor in [3H]LTD4 binding assay	ChEMBL	674	8	2	9	5.5	COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N2CCOCC2)c2ccc(NC(=O)OC3CCCC3)cc12	10.1016/s0960-894x(98)00442-9
	44269877	14967	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determinedInhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined	ChEMBL	601	13	1	8	7.2	CCC(CSC(CCc1ccccc1-c1nnnn1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O	10.1016/S0960-894X(00)80635-6
	CHEMBL1208514	14967	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determinedInhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined	ChEMBL	601	13	1	8	7.2	CCC(CSC(CCc1ccccc1-c1nnnn1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O	10.1016/S0960-894X(00)80635-6
	CHEMBL15232	14967	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determinedInhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined	ChEMBL	601	13	1	8	7.2	CCC(CSC(CCc1ccccc1-c1nnnn1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O	10.1016/S0960-894X(00)80635-6
	44269762	14604	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1	ChEMBL	570	12	2	6	6.0	NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1	10.1016/S0960-894X(00)80635-6
	CHEMBL1204694	14604	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1	ChEMBL	570	12	2	6	6.0	NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1	10.1016/S0960-894X(00)80635-6
	CHEMBL15292	14604	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1	ChEMBL	570	12	2	6	6.0	NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1	10.1016/S0960-894X(00)80635-6
	44269966	14607	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1	ChEMBL	550	12	1	6	7.5	CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O	10.1016/S0960-894X(00)80635-6
	CHEMBL1204697	14607	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1	ChEMBL	550	12	1	6	7.5	CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O	10.1016/S0960-894X(00)80635-6
	CHEMBL15370	14607	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determined; experiment 1	ChEMBL	550	12	1	6	7.5	CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O	10.1016/S0960-894X(00)80635-6
	44360858	119362	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesIn vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranes	ChEMBL	583	12	2	4	8.7	CC1(C)CCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1	10.1016/s0960-894x(98)00051-1
	CHEMBL343934	119362	None	0	Human	Binding	pIC50	=	9.4	9.4	-	0	In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesIn vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranes	ChEMBL	583	12	2	4	8.7	CC1(C)CCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1	10.1016/s0960-894x(98)00051-1
	22849291	108396	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Concentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranesConcentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranes	ChEMBL	573	12	2	4	8.8	CC(CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O	10.1016/0960-894X(95)00023-M
	CHEMBL319802	108396	None	0	Guinea pig	Binding	pIC50	=	9.4	9.4	-	0	Concentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranesConcentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranes	ChEMBL	573	12	2	4	8.8	CC(CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O	10.1016/0960-894X(95)00023-M
	2855	4132	None	63	Guinea pig	Binding	pIC50	=	9.4	9.4	-1	6	Concentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranesConcentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranes	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1016/0960-894X(95)00023-M
	3322	4132	None	63	Guinea pig	Binding	pIC50	=	9.4	9.4	-1	6	Concentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranesConcentration required for inhibition of binding of [3H]LTD4 to guinea pig lung membranes	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1016/0960-894X(95)00023-M

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