Ligand source activities (1 row/activity)
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 5280878 | 107049 | 27 | None | 2 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL288943 | 107049 | 27 | None | 2 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1021/acs.jmedchem.1c01078 | ||
| 3352 | 9150 | 28 | None | -575 | 4 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
| 5280879 | 9150 | 28 | None | -575 | 4 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
| 5863 | 9150 | 28 | None | -575 | 4 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL509456 | 9150 | 28 | None | -575 | 4 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
| 49863644 | 22085 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 498 | 13 | 1 | 5 | 6.1 | O=C(O)COc1ccc(F)cc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213847 | 22085 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 498 | 13 | 1 | 5 | 6.1 | O=C(O)COc1ccc(F)cc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 49863643 | 22084 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 480 | 13 | 1 | 5 | 5.9 | O=C(O)COc1ccccc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213846 | 22084 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 480 | 13 | 1 | 5 | 5.9 | O=C(O)COc1ccccc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 49863685 | 22089 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 471 | 13 | 1 | 6 | 5.4 | N#CCOc1ccc(C(=O)O)cc1C(=O)/C=C/c1ccc(OCCCCOc2ccccc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213918 | 22089 | 0 | None | - | 1 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 471 | 13 | 1 | 6 | 5.4 | N#CCOc1ccc(C(=O)O)cc1C(=O)/C=C/c1ccc(OCCCCOc2ccccc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 3354 | 9148 | 26 | None | -74 | 4 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
| 5280493 | 9148 | 26 | None | -74 | 4 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL451509 | 9148 | 26 | None | -74 | 4 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
| DB08855 | 9148 | 26 | None | -74 | 4 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
| 46919026 | 22088 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 505 | 13 | 1 | 6 | 6.1 | N#CCOc1cc(C(=O)O)ccc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213917 | 22088 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 505 | 13 | 1 | 6 | 6.1 | N#CCOc1cc(C(=O)O)ccc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 1836 | 9370 | 59 | None | -10 | 18 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/j.bmc.2010.06.047 | ||
| 3340 | 9370 | 59 | None | -10 | 18 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/j.bmc.2010.06.047 | ||
| 5281040 | 9370 | 59 | None | -10 | 18 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL787 | 9370 | 59 | None | -10 | 18 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/j.bmc.2010.06.047 | ||
| DB00471 | 9370 | 59 | None | -10 | 18 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/j.bmc.2010.06.047 | ||
| 9829145 | 126105 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 555 | 12 | 2 | 4 | 8.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCC3)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL344180 | 126105 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 555 | 12 | 2 | 4 | 8.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCC3)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 44360643 | 37661 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 559 | 12 | 2 | 5 | 7.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CSC3)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL139757 | 37661 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 559 | 12 | 2 | 5 | 7.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CSC3)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 122183753 | 128992 | 0 | None | 3 | 2 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597618 | 128992 | 0 | None | 3 | 2 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 2855 | 10904 | 104 | None | 1 | 12 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.1c01078 | ||
| 3322 | 10904 | 104 | None | 1 | 12 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.1c01078 | ||
| 5717 | 10904 | 104 | None | 1 | 12 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL603 | 10904 | 104 | None | 1 | 12 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.1c01078 | ||
| DB00549 | 10904 | 104 | None | 1 | 12 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.1c01078 | ||
| 122183752 | 128991 | 0 | None | 17 | 2 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 557 | 11 | 2 | 4 | 6.8 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597617 | 128991 | 0 | None | 17 | 2 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 557 | 11 | 2 | 4 | 6.8 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 44360674 | 125349 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 569 | 12 | 2 | 4 | 8.3 | CC1(C)Cc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL341603 | 125349 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 569 | 12 | 2 | 4 | 8.3 | CC1(C)Cc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1 | 10.1016/j.bmc.2010.06.047 | ||
| 122183751 | 128990 | 0 | None | 1 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 543 | 10 | 2 | 4 | 6.4 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597616 | 128990 | 0 | None | 1 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 543 | 10 | 2 | 4 | 6.4 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 15291446 | 41968 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 541 | 12 | 2 | 4 | 7.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCC3)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL143515 | 41968 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 541 | 12 | 2 | 4 | 7.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCC3)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 44360585 | 125870 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 569 | 12 | 2 | 4 | 8.6 | CC1CCCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL342705 | 125870 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 569 | 12 | 2 | 4 | 8.6 | CC1CCCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21 | 10.1016/j.bmc.2010.06.047 | ||
| 66739117 | 128972 | 0 | None | 9 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 573 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597535 | 128972 | 0 | None | 9 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 573 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 11261220 | 124696 | 0 | None | 5 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 539 | 13 | 2 | 7 | 5.6 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3403186 | 124696 | 0 | None | 5 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 539 | 13 | 2 | 7 | 5.6 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 122183684 | 128964 | 0 | None | 7 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 559 | 14 | 2 | 4 | 7.7 | Cc1c(Cl)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)cn(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597527 | 128964 | 0 | None | 7 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 559 | 14 | 2 | 4 | 7.7 | Cc1c(Cl)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)cn(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 122183758 | 128998 | 0 | None | 19 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597623 | 128998 | 0 | None | 19 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 11398820 | 124565 | 0 | None | -1 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 556 | 13 | 3 | 8 | 4.7 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3401689 | 124565 | 0 | None | -1 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 556 | 13 | 3 | 8 | 4.7 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 2237 | 9936 | 79 | None | -14 | 10 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/j.bmc.2010.06.047 | ||
| 3634 | 9936 | 79 | None | -14 | 10 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/j.bmc.2010.06.047 | ||
| 4887 | 9936 | 79 | None | -14 | 10 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL21333 | 9936 | 79 | None | -14 | 10 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/j.bmc.2010.06.047 | ||
| DB01411 | 9936 | 79 | None | -14 | 10 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/j.bmc.2010.06.047 | ||
| 122183689 | 128969 | 0 | None | 1 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4cc(F)c(F)c(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597532 | 128969 | 0 | None | 1 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4cc(F)c(F)c(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| 44360637 | 125338 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 571 | 15 | 2 | 4 | 8.8 | CCCCc1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)ccc1C | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL341547 | 125338 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 571 | 15 | 2 | 4 | 8.8 | CCCCc1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)ccc1C | 10.1016/j.bmc.2010.06.047 | ||
| 122183682 | 128962 | 0 | None | 2 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 565 | 14 | 2 | 4 | 7.1 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4c(F)ccc(F)c4F)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597525 | 128962 | 0 | None | 2 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 565 | 14 | 2 | 4 | 7.1 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4c(F)ccc(F)c4F)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
| 122183690 | 128971 | 0 | None | 6 | 2 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 557 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597534 | 128971 | 0 | None | 6 | 2 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 557 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 46835000 | 129008 | 0 | None | 1 | 3 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 583 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597633 | 129008 | 0 | None | 1 | 3 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 583 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 23124563 | 121802 | 0 | None | 630 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 546 | 12 | 3 | 6 | 4.4 | O=C(O)CCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342952 | 121802 | 0 | None | 630 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 546 | 12 | 3 | 6 | 4.4 | O=C(O)CCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 44352406 | 28286 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL131611 | 28286 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 11713438 | 128959 | 0 | None | 3 | 2 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597522 | 128959 | 0 | None | 3 | 2 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
| 46834997 | 128999 | 0 | None | 1 | 3 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597624 | 128999 | 0 | None | 1 | 3 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 87131159 | 128970 | 0 | None | 1 | 2 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597533 | 128970 | 0 | None | 1 | 2 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| 46830962 | 129009 | 21 | None | 3 | 3 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 601 | 14 | 2 | 4 | 7.6 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597634 | 129009 | 21 | None | 3 | 3 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 601 | 14 | 2 | 4 | 7.6 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 122183755 | 128995 | 0 | None | 7 | 2 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597620 | 128995 | 0 | None | 7 | 2 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 10839186 | 126485 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 502 | 5 | 1 | 6 | 5.4 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ncc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL34740 | 126485 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 502 | 5 | 1 | 6 | 5.4 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ncc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 10766366 | 20100 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 459 | 7 | 2 | 5 | 5.8 | O=C(O)c1cc(Cl)cc(C(=O)/C=C/c2cccc(OCc3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11921 | 20100 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 459 | 7 | 2 | 5 | 5.8 | O=C(O)c1cc(Cl)cc(C(=O)/C=C/c2cccc(OCc3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| 10646529 | 17163 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 435 | 6 | 2 | 4 | 6.0 | Cc1cc(C(=O)O)c(O)c(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11625 | 17163 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 435 | 6 | 2 | 4 | 6.0 | Cc1cc(C(=O)O)c(O)c(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 49863895 | 22137 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 448 | 7 | 3 | 5 | 5.1 | O=C(O)c1cc(Cl)cc(C(=O)/C=C/c2ccc(OCc3nc4ccccc4[nH]3)cc2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214416 | 22137 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 448 | 7 | 3 | 5 | 5.1 | O=C(O)c1cc(Cl)cc(C(=O)/C=C/c2ccc(OCc3nc4ccccc4[nH]3)cc2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| 9890153 | 169297 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 453 | 4 | 1 | 4 | 6.5 | O=C(O)c1cc(Cl)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL416769 | 169297 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 453 | 4 | 1 | 4 | 6.5 | O=C(O)c1cc(Cl)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 122183763 | 129005 | 0 | None | 4 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2c(F)ccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597630 | 129005 | 0 | None | 4 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2c(F)ccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 11191817 | 121805 | 2 | None | -3 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 11191817 | 121805 | 2 | None | -3 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342955 | 121805 | 2 | None | -3 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3342955 | 121805 | 2 | None | -3 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 5059 | 213140 | 44 | None | 2 | 3 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL8747 | 213140 | 44 | None | 2 | 3 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| 10764782 | 169518 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 424 | 5 | 1 | 6 | 4.7 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ncc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL417135 | 169518 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 424 | 5 | 1 | 6 | 4.7 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ncc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 5059 | 213140 | 44 | None | 2 | 3 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL8747 | 213140 | 44 | None | 2 | 3 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| 11626955 | 158590 | 0 | None | -18 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 471 | 7 | 2 | 8 | 4.6 | CC(=O)c1ccc(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)c(C(F)(F)F)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3965244 | 158590 | 0 | None | -18 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 471 | 7 | 2 | 8 | 4.6 | CC(=O)c1ccc(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)c(C(F)(F)F)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 127043617 | 147167 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1ccc2c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c(C(=O)O)[nH]c2c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3808608 | 147167 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1ccc2c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c(C(=O)O)[nH]c2c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 10792471 | 123485 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 535 | 5 | 1 | 5 | 6.7 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccc(Cl)cc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL33729 | 123485 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 535 | 5 | 1 | 5 | 6.7 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccc(Cl)cc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 11853184 | 124700 | 3 | None | 2 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCn1cc(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3403190 | 124700 | 3 | None | 2 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCn1cc(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1021/acs.jmedchem.5b00741 | ||
| 122183754 | 128993 | 0 | None | 7 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 557 | 11 | 2 | 4 | 6.8 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597619 | 128993 | 0 | None | 7 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 557 | 11 | 2 | 4 | 6.8 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 23124629 | 121804 | 0 | None | 74 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 574 | 14 | 3 | 6 | 5.2 | O=C(O)CCCCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342954 | 121804 | 0 | None | 74 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 574 | 14 | 3 | 6 | 5.2 | O=C(O)CCCCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 127043233 | 147258 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 508 | 7 | 2 | 4 | 7.0 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccccc12)OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3809628 | 147258 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 508 | 7 | 2 | 4 | 7.0 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccccc12)OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 11307317 | 121809 | 0 | None | -194 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 546 | 14 | 3 | 6 | 5.2 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342959 | 121809 | 0 | None | -194 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 546 | 14 | 3 | 6 | 5.2 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 14650410 | 196978 | 16 | None | 6 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 265 | 4 | 1 | 3 | 3.3 | OCc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL5174405 | 196978 | 16 | None | 6 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 265 | 4 | 1 | 3 | 3.3 | OCc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| 44352282 | 125231 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 526 | 9 | 1 | 5 | 5.5 | CN(CCc1ccc(C(=O)O)cc1)S(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL341172 | 125231 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 526 | 9 | 1 | 5 | 5.5 | CN(CCc1ccc(C(=O)O)cc1)S(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 10765224 | 126588 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 433 | 4 | 1 | 4 | 6.2 | Cc1cc(C(=O)O)c2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL34835 | 126588 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 433 | 4 | 1 | 4 | 6.2 | Cc1cc(C(=O)O)c2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 118716774 | 121800 | 0 | None | 281 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 488 | 9 | 2 | 5 | 4.5 | CC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342950 | 121800 | 0 | None | 281 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 488 | 9 | 2 | 5 | 4.5 | CC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 11853184 | 124700 | 3 | None | 2 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCn1cc(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3403190 | 124700 | 3 | None | 2 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCn1cc(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 49863972 | 22165 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 504 | 9 | 2 | 4 | 6.0 | C[C@@H](C(=O)NCc1ccc(CC(=O)O)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214642 | 22165 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 504 | 9 | 2 | 4 | 6.0 | C[C@@H](C(=O)NCc1ccc(CC(=O)O)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 23124775 | 121807 | 0 | None | 2 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 560 | 15 | 3 | 6 | 5.6 | O=C(O)CCCCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342957 | 121807 | 0 | None | 2 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 560 | 15 | 3 | 6 | 5.6 | O=C(O)CCCCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 23124623 | 121808 | 0 | None | -19 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 518 | 12 | 3 | 6 | 4.5 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342958 | 121808 | 0 | None | -19 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 518 | 12 | 3 | 6 | 4.5 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 59599515 | 154926 | 0 | None | 10 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 421 | 9 | 2 | 6 | 5.0 | CCCc1c(OCc2ccc(Oc3ccc(C(=O)O)cn3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3935529 | 154926 | 0 | None | 10 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 421 | 9 | 2 | 6 | 5.0 | CCCc1c(OCc2ccc(Oc3ccc(C(=O)O)cn3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 2855 | 10904 | 104 | None | 1 | 12 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | ||
| 3322 | 10904 | 104 | None | 1 | 12 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | ||
| 5717 | 10904 | 104 | None | 1 | 12 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL603 | 10904 | 104 | None | 1 | 12 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | ||
| DB00549 | 10904 | 104 | None | 1 | 12 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | ||
| 135430849 | 19803 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 449 | 7 | 2 | 7 | 4.6 | O=C(/C=C/c1ccc(OCc2ccc3ccccc3n2)cc1)c1cc(-c2nn[nH]n2)ccc1O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11899 | 19803 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 449 | 7 | 2 | 7 | 4.6 | O=C(/C=C/c1ccc(OCc2ccc3ccccc3n2)cc1)c1cc(-c2nn[nH]n2)ccc1O | 10.1016/j.bmc.2010.06.047 | ||
| 49863945 | 22159 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 479 | 7 | 2 | 6 | 5.0 | O=C(O)c1cccc(C[C@@H]2COc3ccc(OCc4nc5cc(F)ccc5s4)cc3[C@@H]2CO)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214582 | 22159 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 479 | 7 | 2 | 6 | 5.0 | O=C(O)c1cccc(C[C@@H]2COc3ccc(OCc4nc5cc(F)ccc5s4)cc3[C@@H]2CO)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 10764001 | 16803 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 409 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccccc1C(=O)/C=C/c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11509 | 16803 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 409 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccccc1C(=O)/C=C/c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 11690196 | 149544 | 0 | None | -4 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 416 | 7 | 2 | 7 | 4.5 | CC(=O)c1ccc(OCc2ccc(Oc3cccc(-c4nn[nH]n4)c3)cc2)c(C)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3892611 | 149544 | 0 | None | -4 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 416 | 7 | 2 | 7 | 4.5 | CC(=O)c1ccc(OCc2ccc(Oc3cccc(-c4nn[nH]n4)c3)cc2)c(C)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 59599580 | 159495 | 0 | None | -8 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 471 | 7 | 2 | 8 | 4.6 | CC(=O)c1ccc(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)c(C(F)(F)F)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3973048 | 159495 | 0 | None | -8 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 471 | 7 | 2 | 8 | 4.6 | CC(=O)c1ccc(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)c(C(F)(F)F)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 49863766 | 22111 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 645 | 11 | 2 | 7 | 6.1 | COc1ccccc1S(=O)(=O)NC(=O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214096 | 22111 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 645 | 11 | 2 | 7 | 6.1 | COc1ccccc1S(=O)(=O)NC(=O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 118716775 | 121801 | 0 | None | 34 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 502 | 10 | 2 | 5 | 4.9 | CCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342951 | 121801 | 0 | None | 34 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 502 | 10 | 2 | 5 | 4.9 | CCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 59599475 | 155937 | 0 | None | -1 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 421 | 7 | 2 | 8 | 3.7 | CC(=O)c1ccc(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)c(F)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3943547 | 155937 | 0 | None | -1 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 421 | 7 | 2 | 8 | 3.7 | CC(=O)c1ccc(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)c(F)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 127043243 | 147245 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2c(Cl)cccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3809483 | 147245 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2c(Cl)cccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 122183762 | 129004 | 0 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cc(F)cc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597629 | 129004 | 0 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cc(F)cc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 49863872 | 22126 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 480 | 7 | 2 | 6 | 4.5 | O=C(O)c1cc(=O)c2cccc(C(=O)NCc3ccc(OCc4ccc5ccccc5n4)cc3)c2o1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214353 | 22126 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 480 | 7 | 2 | 6 | 4.5 | O=C(O)c1cc(=O)c2cccc(C(=O)NCc3ccc(OCc4ccc5ccccc5n4)cc3)c2o1 | 10.1016/j.bmc.2010.06.047 | ||
| 127043241 | 147253 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccc(Cl)cc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3809556 | 147253 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccc(Cl)cc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 10767627 | 115883 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 497 | 4 | 1 | 4 | 6.6 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL32136 | 115883 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 497 | 4 | 1 | 4 | 6.6 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 10574284 | 123751 | 0 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL33871 | 123751 | 0 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 122183756 | 128996 | 0 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597621 | 128996 | 0 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 11398475 | 121814 | 4 | None | -19 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1C[C@@H](C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342964 | 121814 | 4 | None | -19 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1C[C@@H](C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 10790119 | 17938 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 459 | 7 | 2 | 5 | 5.8 | O=C(O)c1cc(Cl)c(O)c(C(=O)/C=C/c2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11785 | 17938 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 459 | 7 | 2 | 5 | 5.8 | O=C(O)c1cc(Cl)c(O)c(C(=O)/C=C/c2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 10787157 | 120885 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 400 | 3 | 0 | 4 | 6.1 | N#Cc1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL33276 | 120885 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 400 | 3 | 0 | 4 | 6.1 | N#Cc1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 15291450 | 175139 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 501 | 12 | 2 | 4 | 7.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccccn2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL434445 | 175139 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 501 | 12 | 2 | 4 | 7.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccccn2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 118728613 | 124568 | 0 | None | 2 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 488 | 12 | 2 | 5 | 5.4 | O=C(O)CCCN1CCOc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3401692 | 124568 | 0 | None | 2 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 488 | 12 | 2 | 5 | 5.4 | O=C(O)CCCN1CCOc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 49863907 | 22143 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 658 | 9 | 2 | 8 | 6.5 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(OCc3nc4cc(F)c(F)cc4s3)ccc2OC1(C)C | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214477 | 22143 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 658 | 9 | 2 | 8 | 6.5 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(OCc3nc4cc(F)c(F)cc4s3)ccc2OC1(C)C | 10.1016/j.bmc.2010.06.047 | ||
| 46835000 | 129008 | 0 | None | -1 | 3 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 583 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597633 | 129008 | 0 | None | -1 | 3 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 583 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 46834997 | 128999 | 0 | None | -1 | 3 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597624 | 128999 | 0 | None | -1 | 3 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 122183688 | 128968 | 0 | None | 1 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)c(F)cc(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597531 | 128968 | 0 | None | 1 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)c(F)cc(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| 58725448 | 199014 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 583 | 11 | 1 | 3 | 10.0 | CC(C)(C)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL5205127 | 199014 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 583 | 11 | 1 | 3 | 10.0 | CC(C)(C)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| 15291441 | 125365 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 557 | 15 | 2 | 4 | 8.5 | CCCCc1cccc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL341657 | 125365 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 557 | 15 | 2 | 4 | 8.5 | CCCCc1cccc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/j.bmc.2010.06.047 | ||
| 122183687 | 128967 | 0 | None | -2 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 579 | 14 | 2 | 4 | 7.4 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)ccc(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597530 | 128967 | 0 | None | -2 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 579 | 14 | 2 | 4 | 7.4 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)ccc(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| 46830677 | 129006 | 0 | None | 1 | 3 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 623 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597631 | 129006 | 0 | None | 1 | 3 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 623 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| 9804436 | 27411 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1ccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL130846 | 27411 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1ccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 15291439 | 126233 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 543 | 13 | 2 | 4 | 8.0 | CCc1ccc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL345093 | 126233 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 543 | 13 | 2 | 4 | 8.0 | CCc1ccc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C | 10.1016/j.bmc.2010.06.047 | ||
| 46830677 | 129006 | 0 | None | -1 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 623 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597631 | 129006 | 0 | None | -1 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 623 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| 122183683 | 128963 | 0 | None | 4 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 543 | 14 | 2 | 4 | 7.2 | Cc1c(F)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)cn(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597526 | 128963 | 0 | None | 4 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 543 | 14 | 2 | 4 | 7.2 | Cc1c(F)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)cn(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 59599565 | 152093 | 0 | None | 2 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3cc(-c4nn[nH]n4)ccn3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3913281 | 152093 | 0 | None | 2 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3cc(-c4nn[nH]n4)ccn3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 159289 | 108842 | 19 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 333 | 5 | 2 | 7 | 2.5 | COc1ccc2sc(C(=O)Nc3nnn[nH]3)c(OC(C)C)c2c1 | 10.1021/jm00083a023 | ||
| CHEMBL302045 | 108842 | 19 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 333 | 5 | 2 | 7 | 2.5 | COc1ccc2sc(C(=O)Nc3nnn[nH]3)c(OC(C)C)c2c1 | 10.1021/jm00083a023 | ||
| 59599568 | 152828 | 0 | None | 1 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3918914 | 152828 | 0 | None | 1 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 10649046 | 16532 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 499 | 6 | 2 | 4 | 6.5 | O=C(O)c1cc(Br)cc(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11349 | 16532 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 499 | 6 | 2 | 4 | 6.5 | O=C(O)c1cc(Br)cc(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| 44352288 | 124125 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 477 | 10 | 1 | 4 | 7.1 | O=C(O)c1ccc(CCCCOc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL339716 | 124125 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 477 | 10 | 1 | 4 | 7.1 | O=C(O)c1ccc(CCCCOc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 28775506 | 197420 | 7 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 265 | 4 | 1 | 3 | 3.3 | OCc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL5181326 | 197420 | 7 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 265 | 4 | 1 | 3 | 3.3 | OCc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/acs.jmedchem.1c01078 | ||
| 49863608 | 22080 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 517 | 7 | 2 | 5 | 6.2 | Cc1cc(COc2ccc(/C=C/C(=O)c3cc(Br)cc(C(=O)O)c3O)cc2)nc2ccccc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213780 | 22080 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 517 | 7 | 2 | 5 | 6.2 | Cc1cc(COc2ccc(/C=C/C(=O)c3cc(Br)cc(C(=O)O)c3O)cc2)nc2ccccc12 | 10.1016/j.bmc.2010.06.047 | ||
| 127043242 | 147228 | 0 | None | 3981 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)ccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3809333 | 147228 | 0 | None | 3981 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)ccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 11227280 | 124566 | 0 | None | -1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 609 | 14 | 3 | 8 | 3.8 | CS(=O)(=O)NC(=O)C1CN(CCCC(=O)O)c2cccc(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)c2O1 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3401690 | 124566 | 0 | None | -1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 609 | 14 | 3 | 8 | 3.8 | CS(=O)(=O)NC(=O)C1CN(CCCC(=O)O)c2cccc(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)c2O1 | 10.1016/j.bmc.2015.03.011 | ||
| 159289 | 108842 | 19 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 333 | 5 | 2 | 7 | 2.5 | COc1ccc2sc(C(=O)Nc3nnn[nH]3)c(OC(C)C)c2c1 | 10.1021/jm00083a023 | ||
| CHEMBL302045 | 108842 | 19 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 333 | 5 | 2 | 7 | 2.5 | COc1ccc2sc(C(=O)Nc3nnn[nH]3)c(OC(C)C)c2c1 | 10.1021/jm00083a023 | ||
| 2237 | 9936 | 79 | None | -14 | 10 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | ||
| 3634 | 9936 | 79 | None | -14 | 10 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | ||
| 4887 | 9936 | 79 | None | -14 | 10 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL21333 | 9936 | 79 | None | -14 | 10 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | ||
| DB01411 | 9936 | 79 | None | -14 | 10 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | ||
| 128355 | 10441 | 30 | None | 1 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm960088k | ||
| 3329 | 10441 | 30 | None | 1 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm960088k | ||
| CHEMBL18132 | 10441 | 30 | None | 1 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm960088k | ||
| 11455387 | 124697 | 0 | None | -77 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 531 | 14 | 2 | 6 | 5.6 | O=C(O)CCCN1CC(C(=O)O)Oc2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3403187 | 124697 | 0 | None | -77 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 531 | 14 | 2 | 6 | 5.6 | O=C(O)CCCN1CC(C(=O)O)Oc2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 11596869 | 150415 | 0 | None | 8 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 417 | 7 | 2 | 8 | 3.9 | CC(=O)c1ccc(OCc2ccc(Oc3cc(-c4nn[nH]n4)ccn3)cc2)c(C)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3899832 | 150415 | 0 | None | 8 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 417 | 7 | 2 | 8 | 3.9 | CC(=O)c1ccc(OCc2ccc(Oc3cc(-c4nn[nH]n4)ccn3)cc2)c(C)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 127043248 | 147168 | 0 | None | 1819 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1ccc2[nH]c(C(=O)O)c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c2c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3808613 | 147168 | 0 | None | 1819 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1ccc2[nH]c(C(=O)O)c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c2c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 122183760 | 129001 | 0 | None | 2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597626 | 129001 | 0 | None | 2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 44360895 | 41580 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 597 | 13 | 2 | 4 | 8.7 | CCc1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)ccc1C(F)(F)F | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL143115 | 41580 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 597 | 13 | 2 | 4 | 8.7 | CCc1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)ccc1C(F)(F)F | 10.1016/j.bmc.2010.06.047 | ||
| 118729614 | 124698 | 0 | None | 1 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 541 | 14 | 2 | 6 | 6.0 | O=C(O)CCCn1cc(C(=O)O)c(=O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3403188 | 124698 | 0 | None | 1 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 541 | 14 | 2 | 6 | 6.0 | O=C(O)CCCn1cc(C(=O)O)c(=O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 10502162 | 118248 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3ccc(/C=C/c4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL32764 | 118248 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3ccc(/C=C/c4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 14774173 | 196660 | 5 | None | 1 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 279 | 4 | 1 | 3 | 3.5 | O=C(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL5169385 | 196660 | 5 | None | 1 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 279 | 4 | 1 | 3 | 3.5 | O=C(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| 127043049 | 147187 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 561 | 6 | 3 | 3 | 8.2 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)cc(Cl)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3808880 | 147187 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 561 | 6 | 3 | 3 | 8.2 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)cc(Cl)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 23124716 | 121811 | 0 | None | -18 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 534 | 13 | 3 | 7 | 4.3 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342961 | 121811 | 0 | None | -18 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 534 | 13 | 3 | 7 | 4.3 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 46830961 | 129003 | 0 | None | 1 | 3 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597628 | 129003 | 0 | None | 1 | 3 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 122183681 | 128961 | 0 | None | 7 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 545 | 14 | 2 | 4 | 7.4 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4cccc(Cl)c4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597524 | 128961 | 0 | None | 7 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 545 | 14 | 2 | 4 | 7.4 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4cccc(Cl)c4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
| 10074704 | 172084 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 500 | 8 | 2 | 6 | 5.1 | O=C(NCCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL423333 | 172084 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 500 | 8 | 2 | 6 | 5.1 | O=C(NCCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 68695885 | 128960 | 0 | None | 7 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 511 | 14 | 2 | 4 | 6.7 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597523 | 128960 | 0 | None | 7 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 511 | 14 | 2 | 4 | 6.7 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
| 46830961 | 129003 | 0 | None | -1 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597628 | 129003 | 0 | None | -1 | 3 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 44352452 | 25720 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 540 | 9 | 2 | 5 | 5.9 | CC(C)(CNS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccc(C(=O)O)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL128641 | 25720 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 540 | 9 | 2 | 5 | 5.9 | CC(C)(CNS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccc(C(=O)O)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 44352450 | 26251 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 490 | 8 | 2 | 4 | 6.3 | CC(C(=O)Nc1ccc(CC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL129866 | 26251 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 490 | 8 | 2 | 4 | 6.3 | CC(C(=O)Nc1ccc(CC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 10576732 | 17015 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 481 | 11 | 1 | 5 | 6.6 | CCCCOc1ccc(C(=O)O)cc1C(=O)/C=C/c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11609 | 17015 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 481 | 11 | 1 | 5 | 6.6 | CCCCOc1ccc(C(=O)O)cc1C(=O)/C=C/c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 118716776 | 121610 | 0 | None | 12 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 516 | 11 | 2 | 5 | 5.3 | CCCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3341770 | 121610 | 0 | None | 12 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 516 | 11 | 2 | 5 | 5.3 | CCCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 23124741 | 121810 | 0 | None | -1 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 520 | 12 | 3 | 7 | 3.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342960 | 121810 | 0 | None | -1 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 520 | 12 | 3 | 7 | 3.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 10597634 | 17297 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 409 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccccc1C(=O)/C=C/c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11687 | 17297 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 409 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccccc1C(=O)/C=C/c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 10553494 | 115898 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL32138 | 115898 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 1836 | 9370 | 59 | None | -10 | 18 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | ||
| 3340 | 9370 | 59 | None | -10 | 18 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | ||
| 5281040 | 9370 | 59 | None | -10 | 18 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL787 | 9370 | 59 | None | -10 | 18 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | ||
| DB00471 | 9370 | 59 | None | -10 | 18 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | ||
| 127043048 | 147293 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 532 | 6 | 1 | 3 | 8.6 | O=C(/C=C/c1c[nH]c2cc(Cl)cc(Cl)c12)OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3810142 | 147293 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 532 | 6 | 1 | 3 | 8.6 | O=C(/C=C/c1c[nH]c2cc(Cl)cc(Cl)c12)OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 11284237 | 121812 | 0 | None | -1 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 548 | 14 | 3 | 7 | 4.7 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342962 | 121812 | 0 | None | -1 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 548 | 14 | 3 | 7 | 4.7 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 59599459 | 156208 | 0 | None | -1 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3ncccc3-c3nn[nH]n3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3945882 | 156208 | 0 | None | -1 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3ncccc3-c3nn[nH]n3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 49863609 | 22082 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 376 | 7 | 2 | 4 | 4.6 | O=C(O)c1ccc(O)c(C(=O)/C=C/c2ccc(OCC3=CCCC=C3)cc2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213782 | 22082 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 376 | 7 | 2 | 4 | 4.6 | O=C(O)c1ccc(O)c(C(=O)/C=C/c2ccc(OCC3=CCCC=C3)cc2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 59599545 | 153937 | 0 | None | -3 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 437 | 7 | 2 | 8 | 4.2 | CC(=O)c1ccc(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)c(Cl)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3927834 | 153937 | 0 | None | -3 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 437 | 7 | 2 | 8 | 4.2 | CC(=O)c1ccc(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)c(Cl)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 10597232 | 18085 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 402 | 5 | 1 | 4 | 5.9 | N#Cc1ccc(O)c(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11793 | 18085 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 402 | 5 | 1 | 4 | 5.9 | N#Cc1ccc(O)c(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 59599538 | 151823 | 0 | None | 1 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3ccc(-c4nn[nH]n4)cn3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3911282 | 151823 | 0 | None | 1 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3ccc(-c4nn[nH]n4)cn3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 127043236 | 147210 | 0 | None | 660 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 467 | 5 | 3 | 3 | 6.5 | O=C(O)c1[nH]c2ccccc2c1C(=O)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3809164 | 147210 | 0 | None | 660 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 467 | 5 | 3 | 3 | 6.5 | O=C(O)c1[nH]c2ccccc2c1C(=O)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 11353238 | 124695 | 0 | None | -2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 541 | 14 | 2 | 7 | 5.2 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(CCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3403185 | 124695 | 0 | None | -2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 541 | 14 | 2 | 7 | 5.2 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(CCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 49863809 | 22124 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 490 | 8 | 2 | 4 | 6.3 | CC(C(=O)Nc1cccc(CC(=O)O)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214219 | 22124 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 490 | 8 | 2 | 4 | 6.3 | CC(C(=O)Nc1cccc(CC(=O)O)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 127043247 | 147195 | 0 | None | 1995 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 529 | 6 | 3 | 3 | 7.2 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(F)cc(F)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3808968 | 147195 | 0 | None | 1995 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 529 | 6 | 3 | 3 | 7.2 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(F)cc(F)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 10324292 | 22090 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 517 | 5 | 2 | 6 | 5.8 | O=C(O)c1cc(Br)cc2c(=O)c(O)c(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213919 | 22090 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 517 | 5 | 2 | 6 | 5.8 | O=C(O)c1cc(Br)cc2c(=O)c(O)c(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 44352484 | 28260 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 450 | 8 | 2 | 6 | 3.9 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)NCc1ccc(-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL131582 | 28260 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 450 | 8 | 2 | 6 | 3.9 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)NCc1ccc(-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 10651746 | 106667 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 640 | 7 | 1 | 7 | 6.5 | O=C(NS(=O)(=O)c1ccccc1)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL285994 | 106667 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 640 | 7 | 1 | 7 | 6.5 | O=C(NS(=O)(=O)c1ccccc1)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 59599555 | 160327 | 0 | None | -1 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2cccc(Oc3ncccc3-c3nn[nH]n3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3980125 | 160327 | 0 | None | -1 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2cccc(Oc3ncccc3-c3nn[nH]n3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 13626863 | 196901 | 5 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 293 | 4 | 0 | 4 | 3.6 | COC(=O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL5173307 | 196901 | 5 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 293 | 4 | 0 | 4 | 3.6 | COC(=O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| 49863922 | 22150 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 630 | 9 | 2 | 7 | 6.5 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(OCc3ccc4ccc(C)cc4n3)ccc2OC1(C)C | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214531 | 22150 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 630 | 9 | 2 | 7 | 6.5 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(OCc3ccc4ccc(C)cc4n3)ccc2OC1(C)C | 10.1016/j.bmc.2010.06.047 | ||
| 49863921 | 22149 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | C[C@@H](Cc1ccc(C(=O)O)cc1)NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214530 | 22149 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | C[C@@H](Cc1ccc(C(=O)O)cc1)NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 122183685 | 128965 | 0 | None | 1 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 525 | 14 | 2 | 4 | 7.0 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4ccccc4)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597528 | 128965 | 0 | None | 1 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 525 | 14 | 2 | 4 | 7.0 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4ccccc4)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| 46830963 | 129007 | 0 | None | 1 | 3 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 641 | 14 | 2 | 4 | 7.7 | Cc1c(CCCC(=O)O)c2c(F)ccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597632 | 129007 | 0 | None | 1 | 3 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 641 | 14 | 2 | 4 | 7.7 | Cc1c(CCCC(=O)O)c2c(F)ccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| 2237 | 9936 | 79 | None | -14 | 10 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.1c01078 | ||
| 3634 | 9936 | 79 | None | -14 | 10 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.1c01078 | ||
| 4887 | 9936 | 79 | None | -14 | 10 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL21333 | 9936 | 79 | None | -14 | 10 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.1c01078 | ||
| DB01411 | 9936 | 79 | None | -14 | 10 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.1c01078 | ||
| 44352294 | 170220 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1cccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL419796 | 170220 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1cccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 44360752 | 126102 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 557 | 13 | 2 | 4 | 8.6 | Cc1ccc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C(C)C | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL344169 | 126102 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 557 | 13 | 2 | 4 | 8.6 | Cc1ccc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C(C)C | 10.1016/j.bmc.2010.06.047 | ||
| 10436360 | 22081 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 510 | 9 | 1 | 7 | 5.2 | CN(C)CCOc1c(-c2ccc(OCc3ccc4ccccc4n3)cc2)oc2c(C(=O)O)cccc2c1=O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213781 | 22081 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 510 | 9 | 1 | 7 | 5.2 | CN(C)CCOc1c(-c2ccc(OCc3ccc4ccccc4n3)cc2)oc2c(C(=O)O)cccc2c1=O | 10.1016/j.bmc.2010.06.047 | ||
| 57109 | 90258 | 25 | None | 1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm960088k | ||
| CHEMBL22016 | 90258 | 25 | None | 1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm960088k | ||
| 10598159 | 121215 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL33329 | 121215 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 10836133 | 20488 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 425 | 7 | 2 | 5 | 5.1 | O=C(O)c1cccc(C(=O)/C=C/c2cccc(OCc3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11950 | 20488 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 425 | 7 | 2 | 5 | 5.1 | O=C(O)c1cccc(C(=O)/C=C/c2cccc(OCc3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| 44360808 | 39418 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 545 | 13 | 3 | 5 | 6.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc(C(=O)O)cn2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL141300 | 39418 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 545 | 13 | 3 | 5 | 6.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc(C(=O)O)cn2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 10053523 | 22091 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 559 | 8 | 1 | 6 | 6.8 | CCCOc1c(-c2cccc(OCc3ccc4ccccc4n3)c2)oc2c(C(=O)O)cc(Br)cc2c1=O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213920 | 22091 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 559 | 8 | 1 | 6 | 6.8 | CCCOc1c(-c2cccc(OCc3ccc4ccccc4n3)c2)oc2c(C(=O)O)cc(Br)cc2c1=O | 10.1016/j.bmc.2010.06.047 | ||
| 44352142 | 25625 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 454 | 10 | 2 | 4 | 5.2 | O=C(O)CCCc1ccc(C(=O)NCc2ccc(OCc3ccc4ccccc4n3)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL128151 | 25625 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 454 | 10 | 2 | 4 | 5.2 | O=C(O)CCCc1ccc(C(=O)NCc2ccc(OCc3ccc4ccccc4n3)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 118716777 | 121806 | 1 | None | 3 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 546 | 14 | 3 | 6 | 5.2 | O=C(O)CCCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342956 | 121806 | 1 | None | 3 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 546 | 14 | 3 | 6 | 5.2 | O=C(O)CCCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 3381 | 7376 | 27 | None | -17 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1021/ml500298y | ||
| 5311015 | 7376 | 27 | None | -17 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1021/ml500298y | ||
| CHEMBL285954 | 7376 | 27 | None | -17 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1021/ml500298y | ||
| 10600630 | 19384 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 475 | 8 | 2 | 7 | 5.1 | O=C(/C=C/c1cccc(/C=C/c2ccc3ccccc3n2)c1)c1cc(OCc2nn[nH]n2)ccc1O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11870 | 19384 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 475 | 8 | 2 | 7 | 5.1 | O=C(/C=C/c1cccc(/C=C/c2ccc3ccccc3n2)c1)c1cc(OCc2nn[nH]n2)ccc1O | 10.1016/j.bmc.2010.06.047 | ||
| 10836131 | 18040 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 425 | 7 | 2 | 5 | 5.1 | O=C(O)c1ccc(O)c(C(=O)/C=C/c2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11791 | 18040 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 425 | 7 | 2 | 5 | 5.1 | O=C(O)c1ccc(O)c(C(=O)/C=C/c2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 122183686 | 128966 | 0 | None | -3 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 555 | 15 | 2 | 5 | 7.0 | COc1ccccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597529 | 128966 | 0 | None | -3 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 555 | 15 | 2 | 5 | 7.0 | COc1ccccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 118716772 | 121798 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1ccc2c(c1)OC(C(=O)O)CN2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | ||
| CHEMBL3342948 | 121798 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1ccc2c(c1)OC(C(=O)O)CN2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | ||
| 59599552 | 155082 | 0 | None | -12 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 437 | 7 | 2 | 8 | 4.2 | CC(=O)c1ccc(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)c(Cl)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3936830 | 155082 | 0 | None | -12 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 437 | 7 | 2 | 8 | 4.2 | CC(=O)c1ccc(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)c(Cl)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 59599616 | 153042 | 1 | None | 1 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3cccc(-c4nn[nH]n4)c3)nc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3920609 | 153042 | 1 | None | 1 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3cccc(-c4nn[nH]n4)c3)nc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 118729615 | 124699 | 0 | None | -6 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 542 | 15 | 2 | 7 | 6.0 | O=C(O)CCCOc1nc2cccc(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)c2nc1C(=O)O | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3403189 | 124699 | 0 | None | -6 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 542 | 15 | 2 | 7 | 6.0 | O=C(O)CCCOc1nc2cccc(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)c2nc1C(=O)O | 10.1016/j.bmc.2015.03.011 | ||
| 49863923 | 22151 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 626 | 8 | 2 | 6 | 7.1 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(/C=C/c3ccc4ccc(C)cc4n3)ccc2OC1(C)C | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214532 | 22151 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 626 | 8 | 2 | 6 | 7.1 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(/C=C/c3ccc4ccc(C)cc4n3)ccc2OC1(C)C | 10.1016/j.bmc.2010.06.047 | ||
| 122183757 | 128997 | 0 | None | 10 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597622 | 128997 | 0 | None | 10 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 127043618 | 147303 | 0 | None | 2570 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1cccc2c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c(C(=O)O)[nH]c12 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3810210 | 147303 | 0 | None | 2570 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1cccc2c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c(C(=O)O)[nH]c12 | 10.1021/acsmedchemlett.5b00482 | ||
| 10649109 | 126229 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL34507 | 126229 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 11387037 | 121813 | 0 | None | 1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1C[C@H](C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| CHEMBL3342963 | 121813 | 0 | None | 1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1C[C@H](C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
| 168280068 | 197968 | 0 | None | -5 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 293 | 6 | 0 | 3 | 4.6 | CCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL5189181 | 197968 | 0 | None | -5 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 293 | 6 | 0 | 3 | 4.6 | CCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| 136127005 | 22136 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 438 | 7 | 3 | 7 | 3.9 | O=C(/C=C/c1ccc(OCc2nc3ccccc3[nH]2)cc1)c1cc(-c2nnn[nH]2)ccc1O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1214415 | 22136 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 438 | 7 | 3 | 7 | 3.9 | O=C(/C=C/c1ccc(OCc2nc3ccccc3[nH]2)cc1)c1cc(-c2nnn[nH]2)ccc1O | 10.1016/j.bmc.2010.06.047 | ||
| 11796528 | 120930 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL33294 | 120930 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 90871050 | 121797 | 0 | None | 85 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1cccc2c1OC(C(=O)O)CN2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | ||
| CHEMBL3342947 | 121797 | 0 | None | 85 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1cccc2c1OC(C(=O)O)CN2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | ||
| 49863641 | 22083 | 0 | None | - | 1 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 358 | 4 | 1 | 4 | 5.0 | O=C(O)c1cccc2c(=O)cc(-c3ccc(Oc4ccccc4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213844 | 22083 | 0 | None | - | 1 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 358 | 4 | 1 | 4 | 5.0 | O=C(O)c1cccc2c(=O)cc(-c3ccc(Oc4ccccc4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 122183761 | 129002 | 0 | None | -1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 613 | 15 | 2 | 4 | 8.4 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597627 | 129002 | 0 | None | -1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 613 | 15 | 2 | 4 | 8.4 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 127043237 | 147198 | 0 | None | 870 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 495 | 7 | 3 | 3 | 6.8 | O=C(CCc1c(C(=O)O)[nH]c2ccccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3808985 | 147198 | 0 | None | 870 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 495 | 7 | 3 | 3 | 6.8 | O=C(CCc1c(C(=O)O)[nH]c2ccccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 11249398 | 124562 | 0 | None | -1 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 519 | 14 | 2 | 6 | 5.2 | O=C(O)CCCN1CC(C(=O)O)Oc2c(OCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3401686 | 124562 | 0 | None | -1 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 519 | 14 | 2 | 6 | 5.2 | O=C(O)CCCN1CC(C(=O)O)Oc2c(OCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 46830962 | 129009 | 21 | None | -3 | 3 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 601 | 14 | 2 | 4 | 7.6 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597634 | 129009 | 21 | None | -3 | 3 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 601 | 14 | 2 | 4 | 7.6 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 10647443 | 19899 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 455 | 6 | 2 | 4 | 6.4 | O=C(O)c1cc(Cl)cc(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL11905 | 19899 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 455 | 6 | 2 | 4 | 6.4 | O=C(O)c1cc(Cl)cc(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | ||
| 10717271 | 105374 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 425 | 7 | 2 | 5 | 5.1 | O=C(O)c1ccc(O)c(C(=O)/C=C/c2cccc(OCc3ccc4ccccc4n3)c2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL276879 | 105374 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 425 | 7 | 2 | 5 | 5.1 | O=C(O)c1ccc(O)c(C(=O)/C=C/c2cccc(OCc3ccc4ccccc4n3)c2)c1 | 10.1016/j.bmc.2010.06.047 | ||
| 59599577 | 151663 | 0 | None | 1 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3909995 | 151663 | 0 | None | 1 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 10532372 | 22092 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 658 | 8 | 1 | 7 | 8.2 | O=C(O)c1cc(Br)cc2c(=O)c(OCc3ccc4ccccc4n3)c(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213921 | 22092 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 658 | 8 | 1 | 7 | 8.2 | O=C(O)c1cc(Br)cc2c(=O)c(OCc3ccc4ccccc4n3)c(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 122183759 | 129000 | 0 | None | 3 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597625 | 129000 | 0 | None | 3 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
| 127043252 | 147169 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 576 | 7 | 2 | 4 | 8.3 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)cc(Cl)c12)OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3808623 | 147169 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 576 | 7 | 2 | 4 | 8.3 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)cc(Cl)c12)OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 127043053 | 147306 | 0 | None | 537 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2cccc(Cl)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3810290 | 147306 | 0 | None | 537 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2cccc(Cl)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 44352148 | 25583 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 449 | 8 | 1 | 4 | 6.4 | O=C(O)c1ccc(COCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL127842 | 25583 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 449 | 8 | 1 | 4 | 6.4 | O=C(O)c1ccc(COCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 44352326 | 27620 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3cc(OCc4ccc5ccccc5n4)ccc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL131025 | 27620 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3cc(OCc4ccc5ccccc5n4)ccc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 46830963 | 129007 | 0 | None | -1 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 641 | 14 | 2 | 4 | 7.7 | Cc1c(CCCC(=O)O)c2c(F)ccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3597632 | 129007 | 0 | None | -1 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 641 | 14 | 2 | 4 | 7.7 | Cc1c(CCCC(=O)O)c2c(F)ccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
| 127043244 | 147213 | 0 | None | 5888 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 511 | 6 | 3 | 3 | 7.0 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccc(F)cc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3809189 | 147213 | 0 | None | 5888 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 511 | 6 | 3 | 3 | 7.0 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccc(F)cc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 23124680 | 124563 | 0 | None | -12 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 515 | 13 | 2 | 5 | 5.8 | O=C(O)CCCN1CC(C(=O)O)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3401687 | 124563 | 0 | None | -12 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 515 | 13 | 2 | 5 | 5.8 | O=C(O)CCCN1CC(C(=O)O)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 23124664 | 124567 | 0 | None | -12 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 671 | 15 | 3 | 8 | 5.3 | O=C(O)CCCN1CC(C(=O)NS(=O)(=O)c2ccccc2)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3401691 | 124567 | 0 | None | -12 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 671 | 15 | 3 | 8 | 5.3 | O=C(O)CCCN1CC(C(=O)NS(=O)(=O)c2ccccc2)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 59599576 | 149317 | 0 | None | 5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 421 | 9 | 2 | 6 | 5.0 | CCCc1c(OCc2cccc(Oc3cc(C(=O)O)ccn3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| CHEMBL3890848 | 149317 | 0 | None | 5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 421 | 9 | 2 | 6 | 5.0 | CCCc1c(OCc2cccc(Oc3cc(C(=O)O)ccn3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | ||
| 118729613 | 124694 | 0 | None | -1 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 518 | 13 | 3 | 6 | 4.8 | O=C(O)CCCN1CC(CO)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3403184 | 124694 | 0 | None | -1 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 518 | 13 | 3 | 6 | 4.8 | O=C(O)CCCN1CC(CO)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 44352103 | 123468 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | CC(NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccccc1CC(=O)O | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL337195 | 123468 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | CC(NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccccc1CC(=O)O | 10.1016/j.bmc.2010.06.047 | ||
| 11191817 | 121805 | 2 | None | -3 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL3342955 | 121805 | 2 | None | -3 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/acs.jmedchem.5b00741 | ||
| 49863579 | 22077 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 517 | 5 | 2 | 6 | 5.8 | O=C(O)c1cc(Br)cc2c(=O)c(O)c(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL1213720 | 22077 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 517 | 5 | 2 | 6 | 5.8 | O=C(O)c1cc(Br)cc2c(=O)c(O)c(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 23124707 | 124564 | 0 | None | -5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 517 | 14 | 2 | 5 | 5.4 | O=C(O)CCCN1CC(C(=O)O)Oc2c(CCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| CHEMBL3401688 | 124564 | 0 | None | -5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 517 | 14 | 2 | 5 | 5.4 | O=C(O)CCCN1CC(C(=O)O)Oc2c(CCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
| 118716773 | 121799 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1ccc2c(c1)NCC(C(=O)O)O2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | ||
| CHEMBL3342949 | 121799 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1ccc2c(c1)NCC(C(=O)O)O2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | ||
| 44352397 | 27968 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 504 | 7 | 2 | 8 | 4.0 | O=C(NCc1ccc(OCc2ccc3ccccc3n2)cc1)c1cccc2c(=O)cc(-c3nn[nH]n3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL131287 | 27968 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 504 | 7 | 2 | 8 | 4.0 | O=C(NCc1ccc(OCc2ccc3ccccc3n2)cc1)c1cccc2c(=O)cc(-c3nn[nH]n3)oc12 | 10.1016/j.bmc.2010.06.047 | ||
| 127043050 | 147217 | 0 | None | 6456 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 493 | 6 | 3 | 3 | 6.9 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| CHEMBL3809230 | 147217 | 0 | None | 6456 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 493 | 6 | 3 | 3 | 6.9 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
| 44352186 | 28838 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 478 | 7 | 2 | 5 | 6.4 | O=C(Nc1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)OCc1ccc(C(=O)O)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL132167 | 28838 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 478 | 7 | 2 | 5 | 6.4 | O=C(Nc1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)OCc1ccc(C(=O)O)cc1 | 10.1016/j.bmc.2010.06.047 | ||
| 44352154 | 171805 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1ccc(-c2nn[nH]n2)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| CHEMBL422609 | 171805 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1ccc(-c2nn[nH]n2)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1016/j.bmc.2010.06.047 | ||
| 10472005 | 23601 | 0 | None | - | 1 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 333 | 5 | 0 | 4 | 4.3 | COC(=O)COc1cccc(/C=C/c2ccc3cc(C)ccc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL124741 | 23601 | 0 | None | - | 1 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 333 | 5 | 0 | 4 | 4.3 | COC(=O)COc1cccc(/C=C/c2ccc3cc(C)ccc3n2)c1 | 10.1021/jm00099a011 | ||
| 168288290 | 198133 | 0 | None | -95 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 307 | 6 | 0 | 3 | 5.0 | CCC(C)Oc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| CHEMBL5192002 | 198133 | 0 | None | -95 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 307 | 6 | 0 | 3 | 5.0 | CCC(C)Oc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | ||
| 54677430 | 121796 | 0 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 510 | 8 | 2 | 7 | 5.1 | CCN(CC)C(=O)/C=C(\C)c1ccc2oc(C(=O)c3ccc(C#N)cc3)c(NC(=O)/C(C#N)=C(/C)O)c2c1 | 10.1021/ml500298y | ||
| CHEMBL3342946 | 121796 | 0 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 510 | 8 | 2 | 7 | 5.1 | CCN(CC)C(=O)/C=C(\C)c1ccc2oc(C(=O)c3ccc(C#N)cc3)c(NC(=O)/C(C#N)=C(/C)O)c2c1 | 10.1021/ml500298y | ||
| 14626814 | 191118 | 0 | None | - | 0 | Human | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 561 | 8 | 2 | 7 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| CHEMBL48435 | 191118 | 0 | None | - | 0 | Human | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 561 | 8 | 2 | 7 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| 145979664 | 173375 | 0 | None | - | 0 | Human | 10.0 | pKd | = | 10 | Functional | ChEMBL | 595 | 8 | 2 | 7 | 6.0 | COc1cc(C(=O)NS(=O)(=O)c2cccc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| CHEMBL4280282 | 173375 | 0 | None | - | 0 | Human | 10.0 | pKd | = | 10 | Functional | ChEMBL | 595 | 8 | 2 | 7 | 6.0 | COc1cc(C(=O)NS(=O)(=O)c2cccc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| 22848867 | 21532 | 0 | None | - | 1 | Guinea pig | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206453 | 21532 | 0 | None | - | 1 | Guinea pig | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL275357 | 21532 | 0 | None | - | 1 | Guinea pig | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 14626863 | 174690 | 1 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 574 | 8 | 3 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| CHEMBL431348 | 174690 | 1 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 574 | 8 | 3 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| 22848869 | 21371 | 0 | None | - | 1 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204695 | 21371 | 0 | None | - | 1 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15306 | 21371 | 0 | None | - | 1 | Guinea pig | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 145987347 | 173936 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 608 | 8 | 3 | 6 | 6.0 | COc1cc(C(=O)NS(=O)(=O)c2cccc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| CHEMBL4290919 | 173936 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 608 | 8 | 3 | 6 | 6.0 | COc1cc(C(=O)NS(=O)(=O)c2cccc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| 10346 | 9337 | 46 | None | 4 | 2 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| 5281888 | 9337 | 46 | None | 4 | 2 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15177 | 9337 | 46 | None | 4 | 2 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| 22848881 | 21537 | 0 | None | - | 1 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206471 | 21537 | 0 | None | - | 1 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL277533 | 21537 | 0 | None | - | 1 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44269759 | 50949 | 0 | None | - | 1 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 587 | 13 | 2 | 4 | 9.2 | CCC[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15161 | 50949 | 0 | None | - | 1 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 587 | 13 | 2 | 4 | 9.2 | CCC[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 145981186 | 173303 | 1 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 574 | 8 | 3 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| CHEMBL4279086 | 173303 | 1 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 574 | 8 | 3 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| 19794942 | 107155 | 0 | None | - | 0 | Guinea pig | 7.0 | pKd | = | 7 | Functional | ChEMBL | 520 | 16 | 2 | 5 | 6.7 | O=C(O)CCC(/C=C/Cc1ccc(OCCCCOc2ccccc2)cc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL289880 | 107155 | 0 | None | - | 0 | Guinea pig | 7.0 | pKd | = | 7 | Functional | ChEMBL | 520 | 16 | 2 | 5 | 6.7 | O=C(O)CCC(/C=C/Cc1ccc(OCCCCOc2ccccc2)cc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| 145987301 | 173866 | 0 | None | - | 0 | Human | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 592 | 8 | 3 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2cccc(F)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| CHEMBL4289768 | 173866 | 0 | None | - | 0 | Human | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 592 | 8 | 3 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2cccc(F)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| 145992748 | 173805 | 0 | None | - | 0 | Human | 7.6 | pKd | = | 7.6 | Functional | ChEMBL | 588 | 8 | 3 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| CHEMBL4288574 | 173805 | 0 | None | - | 0 | Human | 7.6 | pKd | = | 7.6 | Functional | ChEMBL | 588 | 8 | 3 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| 19794942 | 107155 | 0 | None | - | 0 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 520 | 16 | 2 | 5 | 6.7 | O=C(O)CCC(/C=C/Cc1ccc(OCCCCOc2ccccc2)cc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL289880 | 107155 | 0 | None | - | 0 | Guinea pig | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 520 | 16 | 2 | 5 | 6.7 | O=C(O)CCC(/C=C/Cc1ccc(OCCCCOc2ccccc2)cc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| 145994218 | 174105 | 0 | None | - | 0 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 642 | 8 | 3 | 6 | 6.4 | COc1cc(C(=O)NS(=O)(=O)c2cccc(C(F)(F)F)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| CHEMBL4294239 | 174105 | 0 | None | - | 0 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 642 | 8 | 3 | 6 | 6.4 | COc1cc(C(=O)NS(=O)(=O)c2cccc(C(F)(F)F)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| 22848883 | 21531 | 0 | None | - | 1 | Guinea pig | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206448 | 21531 | 0 | None | - | 1 | Guinea pig | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL274913 | 21531 | 0 | None | - | 1 | Guinea pig | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 105007 | 103875 | 32 | None | - | 1 | Guinea pig | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00388a028 | ||
| CHEMBL267475 | 103875 | 32 | None | - | 1 | Guinea pig | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00388a028 | ||
| CHEMBL267976 | 103875 | 32 | None | - | 1 | Guinea pig | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00388a028 | ||
| 145992231 | 173682 | 0 | None | - | 0 | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 642 | 8 | 3 | 6 | 6.7 | COc1cc(C(=O)NS(=O)(=O)c2cc(Cl)cc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| CHEMBL4286347 | 173682 | 0 | None | - | 0 | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 642 | 8 | 3 | 6 | 6.7 | COc1cc(C(=O)NS(=O)(=O)c2cc(Cl)cc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | ||
| 9829784 | 108650 | 10 | None | - | 0 | Guinea pig | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 582 | 7 | 2 | 7 | 5.9 | C[C@H]1Oc2ccc(OCc3nc4cc(F)ccc4s3)cc2[C@H](O)[C@@H]1Cc1cccc(NS(=O)(=O)C(F)(F)F)c1 | 10.1016/s0960-894x(98)00654-4 | ||
| CHEMBL300701 | 108650 | 10 | None | - | 0 | Guinea pig | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 582 | 7 | 2 | 7 | 5.9 | C[C@H]1Oc2ccc(OCc3nc4cc(F)ccc4s3)cc2[C@H](O)[C@@H]1Cc1cccc(NS(=O)(=O)C(F)(F)F)c1 | 10.1016/s0960-894x(98)00654-4 | ||
| 2237 | 9936 | 79 | None | 14 | 10 | Guinea pig | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(98)00654-4 | ||
| 3634 | 9936 | 79 | None | 14 | 10 | Guinea pig | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(98)00654-4 | ||
| 4887 | 9936 | 79 | None | 14 | 10 | Guinea pig | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(98)00654-4 | ||
| CHEMBL21333 | 9936 | 79 | None | 14 | 10 | Guinea pig | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(98)00654-4 | ||
| DB01411 | 9936 | 79 | None | 14 | 10 | Guinea pig | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(98)00654-4 | ||
| 9956127 | 176160 | 12 | None | - | 0 | Guinea pig | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 465 | 6 | 2 | 6 | 5.0 | O=C(O)c1cccc(C[C@@H]2COc3ccc(OCc4nc5cc(F)ccc5s4)cc3[C@@H]2O)c1 | 10.1016/s0960-894x(98)00654-4 | ||
| CHEMBL442150 | 176160 | 12 | None | - | 0 | Guinea pig | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 465 | 6 | 2 | 6 | 5.0 | O=C(O)c1cccc(C[C@@H]2COc3ccc(OCc4nc5cc(F)ccc5s4)cc3[C@@H]2O)c1 | 10.1016/s0960-894x(98)00654-4 | ||
| 2855 | 10904 | 104 | None | -1 | 12 | Guinea pig | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00654-4 | ||
| 3322 | 10904 | 104 | None | -1 | 12 | Guinea pig | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00654-4 | ||
| 5717 | 10904 | 104 | None | -1 | 12 | Guinea pig | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00654-4 | ||
| CHEMBL603 | 10904 | 104 | None | -1 | 12 | Guinea pig | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00654-4 | ||
| DB00549 | 10904 | 104 | None | -1 | 12 | Guinea pig | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00654-4 | ||
| 9874234 | 120834 | 0 | None | - | 0 | Guinea pig | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 644 | 8 | 2 | 8 | 6.5 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(OCc3nc4cc(F)c(F)cc4s3)ccc2OC1(C)C | 10.1016/s0960-894x(98)00654-4 | ||
| CHEMBL332680 | 120834 | 0 | None | - | 0 | Guinea pig | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 644 | 8 | 2 | 8 | 6.5 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(OCc3nc4cc(F)c(F)cc4s3)ccc2OC1(C)C | 10.1016/s0960-894x(98)00654-4 | ||
| 9830780 | 20103 | 5 | None | - | 0 | Guinea pig | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 636 | 8 | 2 | 7 | 6.8 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(OCc3ccc4ccc(Cl)cc4n3)ccc2OC1(C)C | 10.1016/s0960-894x(98)00654-4 | ||
| CHEMBL119214 | 20103 | 5 | None | - | 0 | Guinea pig | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 636 | 8 | 2 | 7 | 6.8 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(OCc3ccc4ccc(Cl)cc4n3)ccc2OC1(C)C | 10.1016/s0960-894x(98)00654-4 | ||
| 44345841 | 21297 | 0 | None | - | 0 | Guinea pig | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 648 | 7 | 2 | 7 | 7.1 | CC1(C)Oc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@H](O)[C@@H]1Cc1cc(NS(=O)(=O)C(F)(F)F)ccc1Cl | 10.1016/s0960-894x(98)00654-4 | ||
| CHEMBL120200 | 21297 | 0 | None | - | 0 | Guinea pig | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 648 | 7 | 2 | 7 | 7.1 | CC1(C)Oc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@H](O)[C@@H]1Cc1cc(NS(=O)(=O)C(F)(F)F)ccc1Cl | 10.1016/s0960-894x(98)00654-4 | ||
| 44346037 | 120191 | 0 | None | - | 0 | Guinea pig | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 632 | 7 | 2 | 6 | 7.4 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(/C=C/c3ccc4ccc(Cl)cc4n3)ccc2OC1(C)C | 10.1016/s0960-894x(98)00654-4 | ||
| CHEMBL331884 | 120191 | 0 | None | - | 0 | Guinea pig | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 632 | 7 | 2 | 6 | 7.4 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(/C=C/c3ccc4ccc(Cl)cc4n3)ccc2OC1(C)C | 10.1016/s0960-894x(98)00654-4 | ||
| 44345821 | 120126 | 0 | None | - | 0 | Guinea pig | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 614 | 7 | 2 | 7 | 6.5 | CC1(C)Oc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@H](O)[C@@H]1Cc1cccc(NS(=O)(=O)C(F)(F)F)c1 | 10.1016/s0960-894x(98)00654-4 | ||
| CHEMBL331747 | 120126 | 0 | None | - | 0 | Guinea pig | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 614 | 7 | 2 | 7 | 6.5 | CC1(C)Oc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@H](O)[C@@H]1Cc1cccc(NS(=O)(=O)C(F)(F)F)c1 | 10.1016/s0960-894x(98)00654-4 | ||
| 53394034 | 7375 | 22 | None | -21 | 2 | Human | 6.4 | pA2 | = | 6.4 | Functional | Guide to Pharmacology | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 21753081 | ||
| 6196 | 7375 | 22 | None | -21 | 2 | Human | 6.4 | pA2 | = | 6.4 | Functional | Guide to Pharmacology | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 21753081 | ||
| CHEMBL3342945 | 7375 | 22 | None | -21 | 2 | Human | 6.4 | pA2 | = | 6.4 | Functional | Guide to Pharmacology | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 21753081 | ||
| 10002 | 10637 | 0 | None | - | 1 | Human | 8.7 | pA2 | = | 8.7 | Functional | Guide to Pharmacology | 568 | 8 | 3 | 6 | 5.5 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)Nc1ccccc1)C)C(=O)NS(=O)(=O)c1ccccc1 | 29878767 | ||
| 134611898 | 10637 | 0 | None | - | 1 | Human | 8.7 | pA2 | = | 8.7 | Functional | Guide to Pharmacology | 568 | 8 | 3 | 6 | 5.5 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)Nc1ccccc1)C)C(=O)NS(=O)(=O)c1ccccc1 | 29878767 | ||
| 6194 | 9610 | 0 | None | -61 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | 639 | 26 | 7 | 8 | 3.0 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)NC | 21078884 | ||
| 73755185 | 9610 | 0 | None | -61 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | 639 | 26 | 7 | 8 | 3.0 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)NC | 21078884 | ||
| 3352 | 9150 | 28 | None | -575 | 4 | Human | 6.4 | pEC50 | = | 6.4 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 21078884 | ||
| 5280879 | 9150 | 28 | None | -575 | 4 | Human | 6.4 | pEC50 | = | 6.4 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 21078884 | ||
| 5863 | 9150 | 28 | None | -575 | 4 | Human | 6.4 | pEC50 | = | 6.4 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 21078884 | ||
| CHEMBL509456 | 9150 | 28 | None | -575 | 4 | Human | 6.4 | pEC50 | = | 6.4 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 21078884 | ||
| 3352 | 9150 | 28 | None | -575 | 4 | Human | 6.7 | pEC50 | = | 6.7 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | ||
| 5280879 | 9150 | 28 | None | -575 | 4 | Human | 6.7 | pEC50 | = | 6.7 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | ||
| 5863 | 9150 | 28 | None | -575 | 4 | Human | 6.7 | pEC50 | = | 6.7 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | ||
| CHEMBL509456 | 9150 | 28 | None | -575 | 4 | Human | 6.7 | pEC50 | = | 6.7 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | ||
| 3352 | 9150 | 28 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10462554 | ||
| 3352 | 9150 | 28 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | ||
| 3352 | 9150 | 28 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | ||
| 5280879 | 9150 | 28 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10462554 | ||
| 5280879 | 9150 | 28 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | ||
| 5280879 | 9150 | 28 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | ||
| 5863 | 9150 | 28 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10462554 | ||
| 5863 | 9150 | 28 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | ||
| 5863 | 9150 | 28 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | ||
| CHEMBL509456 | 9150 | 28 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10462554 | ||
| CHEMBL509456 | 9150 | 28 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | ||
| CHEMBL509456 | 9150 | 28 | None | -575 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | ||
| 3354 | 9148 | 26 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10462554 | ||
| 3354 | 9148 | 26 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10913337 | ||
| 3354 | 9148 | 26 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | ||
| 5280493 | 9148 | 26 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10462554 | ||
| 5280493 | 9148 | 26 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10913337 | ||
| 5280493 | 9148 | 26 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | ||
| CHEMBL451509 | 9148 | 26 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10462554 | ||
| CHEMBL451509 | 9148 | 26 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10913337 | ||
| CHEMBL451509 | 9148 | 26 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | ||
| DB08855 | 9148 | 26 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10462554 | ||
| DB08855 | 9148 | 26 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10913337 | ||
| DB08855 | 9148 | 26 | None | -74 | 4 | Human | 7.6 | pEC50 | = | 7.6 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | ||
| 3354 | 9148 | 26 | None | -74 | 4 | Human | 7.7 | pEC50 | = | 7.7 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | ||
| 5280493 | 9148 | 26 | None | -74 | 4 | Human | 7.7 | pEC50 | = | 7.7 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | ||
| CHEMBL451509 | 9148 | 26 | None | -74 | 4 | Human | 7.7 | pEC50 | = | 7.7 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | ||
| DB08855 | 9148 | 26 | None | -74 | 4 | Human | 7.7 | pEC50 | = | 7.7 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | ||
| 3353 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 3353 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | ||
| 3353 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | ||
| 3353 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | ||
| 3353 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 17558309 | ||
| 3353 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | ||
| 3412 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 3412 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | ||
| 3412 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | ||
| 3412 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | ||
| 3412 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 17558309 | ||
| 3412 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | ||
| 6435286 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 6435286 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | ||
| 6435286 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | ||
| 6435286 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | ||
| 6435286 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 17558309 | ||
| 6435286 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | ||
| CHEMBL1521056 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| CHEMBL1521056 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | ||
| CHEMBL1521056 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | ||
| CHEMBL1521056 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | ||
| CHEMBL1521056 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 17558309 | ||
| CHEMBL1521056 | 9149 | 0 | None | -4 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | ||
| 3353 | 9149 | 0 | None | -4 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | ||
| 3412 | 9149 | 0 | None | -4 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | ||
| 6435286 | 9149 | 0 | None | -4 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | ||
| CHEMBL1521056 | 9149 | 0 | None | -4 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | ||
| 3353 | 9149 | 0 | None | -4 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 3412 | 9149 | 0 | None | -4 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 6435286 | 9149 | 0 | None | -4 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| CHEMBL1521056 | 9149 | 0 | None | -4 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 3353 | 9149 | 0 | None | -4 | 4 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 3412 | 9149 | 0 | None | -4 | 4 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 6435286 | 9149 | 0 | None | -4 | 4 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| CHEMBL1521056 | 9149 | 0 | None | -4 | 4 | Human | 9.4 | pEC50 | = | 9.4 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 10581 | 7770 | 0 | None | 1819 | 2 | Human | 9.0 | pIC50 | < | 9 | Functional | Guide to Pharmacology | 587 | 17 | 2 | 7 | 5.4 | O=C(CN1CC(Oc2c1cccc2CC(=O)c1ccc(cc1)OCCCCCc1ccccc1)C(=O)O)CCCC(=O)O | 31811124 | ||
| 145996520 | 7770 | 0 | None | 1819 | 2 | Human | 9.0 | pIC50 | < | 9 | Functional | Guide to Pharmacology | 587 | 17 | 2 | 7 | 5.4 | O=C(CN1CC(Oc2c1cccc2CC(=O)c1ccc(cc1)OCCCCCc1ccccc1)C(=O)O)CCCC(=O)O | 31811124 | ||
| 2237 | 9936 | 79 | None | -14 | 10 | Human | 8.0 | pIC50 | = | 8 | Functional | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| 3634 | 9936 | 79 | None | -14 | 10 | Human | 8.0 | pIC50 | = | 8 | Functional | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| 4887 | 9936 | 79 | None | -14 | 10 | Human | 8.0 | pIC50 | = | 8 | Functional | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| CHEMBL21333 | 9936 | 79 | None | -14 | 10 | Human | 8.0 | pIC50 | = | 8 | Functional | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| DB01411 | 9936 | 79 | None | -14 | 10 | Human | 8.0 | pIC50 | = | 8 | Functional | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| 10582 | 7778 | 0 | None | -194 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | Guide to Pharmacology | 573 | 17 | 2 | 6 | 6.2 | OC(=O)CCCCN1CC(Oc2c1cccc2CC(=O)c1ccc(cc1)OCCCCCCc1ccccc1)C(=O)O | 31811124 | ||
| 145996521 | 7778 | 0 | None | -194 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | Guide to Pharmacology | 573 | 17 | 2 | 6 | 6.2 | OC(=O)CCCCN1CC(Oc2c1cccc2CC(=O)c1ccc(cc1)OCCCCCCc1ccccc1)C(=O)O | 31811124 | ||
| 2237 | 9936 | 79 | None | -14 | 10 | Human | 10.0 | pIC50 | = | 10 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| 3634 | 9936 | 79 | None | -14 | 10 | Human | 10.0 | pIC50 | = | 10 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| 4887 | 9936 | 79 | None | -14 | 10 | Human | 10.0 | pIC50 | = | 10 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| CHEMBL21333 | 9936 | 79 | None | -14 | 10 | Human | 10.0 | pIC50 | = | 10 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| DB01411 | 9936 | 79 | None | -14 | 10 | Human | 10.0 | pIC50 | = | 10 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| 3381 | 7376 | 27 | None | -17 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 20423349 | ||
| 5311015 | 7376 | 27 | None | -17 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 20423349 | ||
| CHEMBL285954 | 7376 | 27 | None | -17 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 20423349 | ||
| 3381 | 7376 | 27 | None | -17 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 11093801 | ||
| 5311015 | 7376 | 27 | None | -17 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 11093801 | ||
| CHEMBL285954 | 7376 | 27 | None | -17 | 3 | Human | 6.4 | pIC50 | = | 6.4 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 11093801 | ||
| 3354 | 9148 | 26 | None | -74 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | ||
| 5280493 | 9148 | 26 | None | -74 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | ||
| CHEMBL451509 | 9148 | 26 | None | -74 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | ||
| DB08855 | 9148 | 26 | None | -74 | 4 | Human | 6.5 | pIC50 | = | 6.5 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | ||
| 3352 | 9150 | 28 | None | -575 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | ||
| 5280879 | 9150 | 28 | None | -575 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | ||
| 5863 | 9150 | 28 | None | -575 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | ||
| CHEMBL509456 | 9150 | 28 | None | -575 | 4 | Human | 6.8 | pIC50 | = | 6.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | ||
| 3334 | 9921 | 9 | None | 48 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10462554 | ||
| 60842 | 9921 | 9 | None | 48 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10462554 | ||
| CHEMBL22776 | 9921 | 9 | None | 48 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10462554 | ||
| 2855 | 10904 | 104 | None | 1 | 12 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | ||
| 3322 | 10904 | 104 | None | 1 | 12 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | ||
| 5717 | 10904 | 104 | None | 1 | 12 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | ||
| CHEMBL603 | 10904 | 104 | None | 1 | 12 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | ||
| DB00549 | 10904 | 104 | None | 1 | 12 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | ||
| 3353 | 9149 | 0 | None | -4 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | ||
| 3412 | 9149 | 0 | None | -4 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | ||
| 6435286 | 9149 | 0 | None | -4 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | ||
| CHEMBL1521056 | 9149 | 0 | None | -4 | 4 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | ||
| 2237 | 9936 | 79 | None | -14 | 10 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10391245 | ||
| 2237 | 9936 | 79 | None | -14 | 10 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| 3634 | 9936 | 79 | None | -14 | 10 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10391245 | ||
| 3634 | 9936 | 79 | None | -14 | 10 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| 4887 | 9936 | 79 | None | -14 | 10 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10391245 | ||
| 4887 | 9936 | 79 | None | -14 | 10 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| CHEMBL21333 | 9936 | 79 | None | -14 | 10 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10391245 | ||
| CHEMBL21333 | 9936 | 79 | None | -14 | 10 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| DB01411 | 9936 | 79 | None | -14 | 10 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10391245 | ||
| DB01411 | 9936 | 79 | None | -14 | 10 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | ||
| 3334 | 9921 | 9 | None | 48 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10462554 | ||
| 60842 | 9921 | 9 | None | 48 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10462554 | ||
| CHEMBL22776 | 9921 | 9 | None | 48 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10462554 | ||
| 1836 | 9370 | 59 | None | -10 | 18 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| 3340 | 9370 | 59 | None | -10 | 18 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| 5281040 | 9370 | 59 | None | -10 | 18 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| CHEMBL787 | 9370 | 59 | None | -10 | 18 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| DB00471 | 9370 | 59 | None | -10 | 18 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| 2855 | 10904 | 104 | None | 1 | 12 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| 3322 | 10904 | 104 | None | 1 | 12 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| 5717 | 10904 | 104 | None | 1 | 12 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| CHEMBL603 | 10904 | 104 | None | 1 | 12 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| DB00549 | 10904 | 104 | None | 1 | 12 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| 1836 | 9370 | 59 | None | -10 | 18 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10391245 | ||
| 1836 | 9370 | 59 | None | -10 | 18 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| 3340 | 9370 | 59 | None | -10 | 18 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10391245 | ||
| 3340 | 9370 | 59 | None | -10 | 18 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| 5281040 | 9370 | 59 | None | -10 | 18 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10391245 | ||
| 5281040 | 9370 | 59 | None | -10 | 18 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| CHEMBL787 | 9370 | 59 | None | -10 | 18 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10391245 | ||
| CHEMBL787 | 9370 | 59 | None | -10 | 18 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| DB00471 | 9370 | 59 | None | -10 | 18 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10391245 | ||
| DB00471 | 9370 | 59 | None | -10 | 18 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | ||
| 2855 | 10904 | 104 | None | 1 | 12 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10391245 | ||
| 2855 | 10904 | 104 | None | 1 | 12 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| 3322 | 10904 | 104 | None | 1 | 12 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10391245 | ||
| 3322 | 10904 | 104 | None | 1 | 12 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| 5717 | 10904 | 104 | None | 1 | 12 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10391245 | ||
| 5717 | 10904 | 104 | None | 1 | 12 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| CHEMBL603 | 10904 | 104 | None | 1 | 12 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10391245 | ||
| CHEMBL603 | 10904 | 104 | None | 1 | 12 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| DB00549 | 10904 | 104 | None | 1 | 12 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10391245 | ||
| DB00549 | 10904 | 104 | None | 1 | 12 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | ||
| 6193 | 10756 | 38 | None | -1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 1666333 | ||
| 6509849 | 10756 | 38 | None | -1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 1666333 | ||
| CHEMBL280481 | 10756 | 38 | None | -1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 1666333 | ||
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 2237 | 9936 | 79 | None | 4 | 3 | Guinea pig | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| 3634 | 9936 | 79 | None | 4 | 3 | Guinea pig | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| 4887 | 9936 | 79 | None | 4 | 3 | Guinea pig | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| CHEMBL21333 | 9936 | 79 | None | 4 | 3 | Guinea pig | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| DB01411 | 9936 | 79 | None | 4 | 3 | Guinea pig | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| 15236851 | 119576 | 0 | None | - | 0 | Guinea pig | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 573 | 12 | 2 | 4 | 8.8 | CC[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL330649 | 119576 | 0 | None | - | 0 | Guinea pig | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 573 | 12 | 2 | 4 | 8.8 | CC[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(95)00023-M | ||
| 22848867 | 21532 | 0 | None | - | 1 | Guinea pig | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206453 | 21532 | 0 | None | - | 1 | Guinea pig | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL275357 | 21532 | 0 | None | - | 1 | Guinea pig | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 9829145 | 126105 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 555 | 12 | 2 | 4 | 8.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL344180 | 126105 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 555 | 12 | 2 | 4 | 8.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| 44329532 | 214421 | 0 | None | - | 0 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 573 | 11 | 2 | 4 | 8.8 | C[C@@H](S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)[C@H](C)C(=O)O | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL95234 | 214421 | 0 | None | - | 0 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 573 | 11 | 2 | 4 | 8.8 | C[C@@H](S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)[C@H](C)C(=O)O | 10.1016/0960-894X(95)00023-M | ||
| 10099896 | 215192 | 15 | None | - | 0 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 587 | 12 | 2 | 4 | 9.2 | CC(C)(CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL99775 | 215192 | 15 | None | - | 0 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 587 | 12 | 2 | 4 | 9.2 | CC(C)(CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/0960-894X(95)00023-M | ||
| 10074173 | 23379 | 0 | None | - | 0 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 486 | 11 | 2 | 5 | 5.9 | NC(=O)CCSC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL124095 | 23379 | 0 | None | - | 0 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 486 | 11 | 2 | 5 | 5.9 | NC(=O)CCSC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| 22848867 | 21532 | 0 | None | - | 1 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206453 | 21532 | 0 | None | - | 1 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL275357 | 21532 | 0 | None | - | 1 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 15859376 | 214724 | 0 | None | - | 0 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 559 | 11 | 2 | 4 | 8.6 | C[C@@H](CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL96986 | 214724 | 0 | None | - | 0 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 559 | 11 | 2 | 4 | 8.6 | C[C@@H](CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| 44269827 | 21367 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 558 | 12 | 2 | 6 | 7.1 | O=C(O)CCSC(CCc1ccccc1-c1nc[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204691 | 21367 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 558 | 12 | 2 | 6 | 7.1 | O=C(O)CCSC(CCc1ccccc1-c1nc[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL14819 | 21367 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 558 | 12 | 2 | 6 | 7.1 | O=C(O)CCSC(CCc1ccccc1-c1nc[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44320022 | 112771 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 625 | 12 | 2 | 5 | 9.7 | CC(C)(O)c1ccc(CC[C@@H](SCC2(CC(=O)O)CC2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)cc1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL313187 | 112771 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 625 | 12 | 2 | 5 | 9.7 | CC(C)(O)c1ccc(CC[C@@H](SCC2(CC(=O)O)CC2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)cc1 | 10.1016/0960-894X(95)00448-3 | ||
| 15872197 | 212092 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 632 | 8 | 2 | 8 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(C)C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL79366 | 212092 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 632 | 8 | 2 | 8 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(C)C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 44213972 | 212160 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 694 | 9 | 2 | 8 | 7.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(C)c2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL79952 | 212160 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 694 | 9 | 2 | 8 | 7.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(C)c2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 44461050 | 212576 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 674 | 8 | 2 | 9 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N2CCOCC2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL83166 | 212576 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 674 | 8 | 2 | 9 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N2CCOCC2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 44269877 | 21733 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 601 | 13 | 1 | 8 | 7.2 | CCC(CSC(CCc1ccccc1-c1nnnn1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1208514 | 21733 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 601 | 13 | 1 | 8 | 7.2 | CCC(CSC(CCc1ccccc1-c1nnnn1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15232 | 21733 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 601 | 13 | 1 | 8 | 7.2 | CCC(CSC(CCc1ccccc1-c1nnnn1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44269762 | 21370 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 570 | 12 | 2 | 6 | 6.0 | NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204694 | 21370 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 570 | 12 | 2 | 6 | 6.0 | NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15292 | 21370 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 570 | 12 | 2 | 6 | 6.0 | NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44269966 | 21373 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 550 | 12 | 1 | 6 | 7.5 | CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204697 | 21373 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 550 | 12 | 1 | 6 | 7.5 | CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15370 | 21373 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 550 | 12 | 1 | 6 | 7.5 | CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44360858 | 126076 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 583 | 12 | 2 | 4 | 8.7 | CC1(C)CCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL343934 | 126076 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 583 | 12 | 2 | 4 | 8.7 | CC1(C)CCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1 | 10.1016/s0960-894x(98)00051-1 | ||
| 22849291 | 115117 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 573 | 12 | 2 | 4 | 8.8 | CC(CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL319802 | 115117 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 573 | 12 | 2 | 4 | 8.8 | CC(CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/0960-894X(95)00023-M | ||
| 2855 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00023-M | ||
| 3322 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00023-M | ||
| 5717 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL603 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00023-M | ||
| DB00549 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00023-M | ||
| 22849284 | 214831 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 573 | 11 | 2 | 4 | 8.8 | CC(S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(C)C(=O)O | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL97576 | 214831 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 573 | 11 | 2 | 4 | 8.8 | CC(S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(C)C(=O)O | 10.1016/0960-894X(95)00023-M | ||
| 15291446 | 41968 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 541 | 12 | 2 | 4 | 7.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL143515 | 41968 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 541 | 12 | 2 | 4 | 7.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| 44269964 | 21543 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 590 | 14 | 2 | 5 | 7.7 | CCNC(=O)c1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206505 | 21543 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 590 | 14 | 2 | 5 | 7.7 | CCNC(=O)c1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL280310 | 21543 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 590 | 14 | 2 | 5 | 7.7 | CCNC(=O)c1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44360585 | 125870 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 569 | 12 | 2 | 4 | 8.6 | CC1CCCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL342705 | 125870 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 569 | 12 | 2 | 4 | 8.6 | CC1CCCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21 | 10.1016/s0960-894x(98)00051-1 | ||
| 44319718 | 112774 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 637 | 12 | 2 | 5 | 9.8 | O=C(O)CC1(CS[C@H](CCc2cccc(C3(O)CCC3)c2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL313195 | 112774 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 637 | 12 | 2 | 5 | 9.8 | O=C(O)CC1(CS[C@H](CCc2cccc(C3(O)CCC3)c2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 44270016 | 21369 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 562 | 13 | 2 | 5 | 7.1 | CCC(CSC(CCc1ccccc1C(N)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204693 | 21369 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 562 | 13 | 2 | 5 | 7.1 | CCC(CSC(CCc1ccccc1C(N)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15120 | 21369 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 562 | 13 | 2 | 5 | 7.1 | CCC(CSC(CCc1ccccc1C(N)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44269966 | 21373 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 550 | 12 | 1 | 6 | 7.5 | CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204697 | 21373 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 550 | 12 | 1 | 6 | 7.5 | CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15370 | 21373 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 550 | 12 | 1 | 6 | 7.5 | CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44461124 | 111324 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 660 | 10 | 2 | 8 | 6.5 | CCN(CC)C(=O)n1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(NC(=O)OC3CCCC3)ccc21 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL310446 | 111324 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 660 | 10 | 2 | 8 | 6.5 | CCN(CC)C(=O)n1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(NC(=O)OC3CCCC3)ccc21 | 10.1016/s0960-894x(98)00442-9 | ||
| 44213973 | 112192 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 604 | 8 | 3 | 8 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(N)=O)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL311868 | 112192 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 604 | 8 | 3 | 8 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(N)=O)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 10439506 | 212102 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 675 | 11 | 3 | 9 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)NCCN(C)C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL79479 | 212102 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 675 | 11 | 3 | 9 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)NCCN(C)C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 10372711 | 212140 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 722 | 12 | 3 | 8 | 7.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)NCCCc2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL79741 | 212140 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 722 | 12 | 3 | 8 | 7.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)NCCCc2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 1836 | 9370 | 59 | None | -1 | 15 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm960088k | ||
| 3340 | 9370 | 59 | None | -1 | 15 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm960088k | ||
| 5281040 | 9370 | 59 | None | -1 | 15 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm960088k | ||
| CHEMBL787 | 9370 | 59 | None | -1 | 15 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm960088k | ||
| DB00471 | 9370 | 59 | None | -1 | 15 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm960088k | ||
| 1836 | 9370 | 59 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/0960-894X(95)00023-M | ||
| 3340 | 9370 | 59 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/0960-894X(95)00023-M | ||
| 5281040 | 9370 | 59 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL787 | 9370 | 59 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/0960-894X(95)00023-M | ||
| DB00471 | 9370 | 59 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/0960-894X(95)00023-M | ||
| 1836 | 9370 | 59 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b00472 | ||
| 3340 | 9370 | 59 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b00472 | ||
| 5281040 | 9370 | 59 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b00472 | ||
| CHEMBL787 | 9370 | 59 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b00472 | ||
| DB00471 | 9370 | 59 | None | 1 | 15 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b00472 | ||
| 44288760 | 168958 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 561 | 13 | 2 | 5 | 8.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL416251 | 168958 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 561 | 13 | 2 | 5 | 8.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44269410 | 21362 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 525 | 13 | 2 | 4 | 8.3 | CC(CC[C@H](SCCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1204685 | 21362 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 525 | 13 | 2 | 4 | 8.3 | CC(CC[C@H](SCCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL14268 | 21362 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 525 | 13 | 2 | 4 | 8.3 | CC(CC[C@H](SCCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 9829365 | 21368 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | CC(CSC(CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204692 | 21368 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | CC(CSC(CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15035 | 21368 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | CC(CSC(CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 19767826 | 21540 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 604 | 14 | 2 | 5 | 8.8 | CCOC(=O)Nc1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206492 | 21540 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 604 | 14 | 2 | 5 | 8.8 | CCOC(=O)Nc1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL279630 | 21540 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 604 | 14 | 2 | 5 | 8.8 | CCOC(=O)Nc1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44270023 | 50760 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 576 | 12 | 1 | 5 | 7.3 | CC(CSC(CCc1ccccc1C(=O)N(C)C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15132 | 50760 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 576 | 12 | 1 | 5 | 7.3 | CC(CSC(CCc1ccccc1C(=O)N(C)C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 9809348 | 213119 | 1 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 625 | 12 | 2 | 5 | 9.7 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL87337 | 213119 | 1 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 625 | 12 | 2 | 5 | 9.7 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| 44360674 | 125349 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 569 | 12 | 2 | 4 | 8.3 | CC1(C)Cc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL341603 | 125349 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 569 | 12 | 2 | 4 | 8.3 | CC1(C)Cc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1 | 10.1016/s0960-894x(98)00051-1 | ||
| 44269954 | 21530 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 584 | 13 | 2 | 6 | 6.7 | CS(=O)(=O)Nc1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206442 | 21530 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 584 | 13 | 2 | 6 | 6.7 | CS(=O)(=O)Nc1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL274049 | 21530 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 584 | 13 | 2 | 6 | 6.7 | CS(=O)(=O)Nc1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 22849285 | 214450 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 573 | 12 | 2 | 4 | 8.9 | CCC(CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL95362 | 214450 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 573 | 12 | 2 | 4 | 8.9 | CCC(CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| 15859377 | 214439 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 559 | 11 | 2 | 4 | 8.6 | C[C@H](CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL95317 | 214439 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 559 | 11 | 2 | 4 | 8.6 | C[C@H](CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| 44288760 | 168958 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 561 | 13 | 2 | 5 | 8.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL416251 | 168958 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 561 | 13 | 2 | 5 | 8.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44269347 | 21365 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 589 | 13 | 2 | 4 | 9.2 | CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1204689 | 21365 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 589 | 13 | 2 | 4 | 9.2 | CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL14451 | 21365 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 589 | 13 | 2 | 4 | 9.2 | CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 44269378 | 21527 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 587 | 12 | 2 | 4 | 9.5 | CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1206432 | 21527 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 587 | 12 | 2 | 4 | 9.5 | CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL273343 | 21527 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 587 | 12 | 2 | 4 | 9.5 | CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 44209267 | 21539 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 602 | 12 | 1 | 5 | 8.0 | O=C(O)CCSC(CCc1ccccc1C(=O)N1CCCCC1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206480 | 21539 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 602 | 12 | 1 | 5 | 8.0 | O=C(O)CCSC(CCc1ccccc1C(=O)N1CCCCC1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL278411 | 21539 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 602 | 12 | 1 | 5 | 8.0 | O=C(O)CCSC(CCc1ccccc1C(=O)N1CCCCC1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44270043 | 21372 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 597 | 13 | 1 | 6 | 7.4 | CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204696 | 21372 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 597 | 13 | 1 | 6 | 7.4 | CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15344 | 21372 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 597 | 13 | 1 | 6 | 7.4 | CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44269762 | 21370 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 570 | 12 | 2 | 6 | 6.0 | NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204694 | 21370 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 570 | 12 | 2 | 6 | 6.0 | NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15292 | 21370 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 570 | 12 | 2 | 6 | 6.0 | NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44269954 | 21530 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 584 | 13 | 2 | 6 | 6.7 | CS(=O)(=O)Nc1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206442 | 21530 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 584 | 13 | 2 | 6 | 6.7 | CS(=O)(=O)Nc1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL274049 | 21530 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 584 | 13 | 2 | 6 | 6.7 | CS(=O)(=O)Nc1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 19767826 | 21540 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 604 | 14 | 2 | 5 | 8.8 | CCOC(=O)Nc1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206492 | 21540 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 604 | 14 | 2 | 5 | 8.8 | CCOC(=O)Nc1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL279630 | 21540 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 604 | 14 | 2 | 5 | 8.8 | CCOC(=O)Nc1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44360643 | 37661 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 559 | 12 | 2 | 5 | 7.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CSC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL139757 | 37661 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 559 | 12 | 2 | 5 | 7.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CSC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| 44319717 | 168641 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 637 | 12 | 2 | 5 | 9.8 | O=C(O)CC1(CS[C@H](CCc2ccc(C3(O)CCC3)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL414885 | 168641 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 637 | 12 | 2 | 5 | 9.8 | O=C(O)CC1(CS[C@H](CCc2ccc(C3(O)CCC3)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 9985552 | 113997 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 573 | 11 | 2 | 4 | 8.9 | CC(C)(CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL316688 | 113997 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 573 | 11 | 2 | 4 | 8.9 | CC(C)(CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| 5280878 | 107049 | 27 | None | 2 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/j.bmcl.2013.01.025 | ||
| CHEMBL288943 | 107049 | 27 | None | 2 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/j.bmcl.2013.01.025 | ||
| 44288372 | 106915 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 617 | 14 | 2 | 5 | 9.3 | CC(CC(F)(F)F)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL287722 | 106915 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 617 | 14 | 2 | 5 | 9.3 | CC(CC(F)(F)F)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| 44319715 | 212921 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 597 | 12 | 2 | 5 | 8.9 | O=C(O)CC1(CS[C@H](CCc2ccccc2CO)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL86063 | 212921 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 597 | 12 | 2 | 5 | 8.9 | O=C(O)CC1(CS[C@H](CCc2ccccc2CO)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 15290709 | 113349 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 593 | 12 | 2 | 5 | 8.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sc(F)c(F)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL314237 | 113349 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 593 | 12 | 2 | 5 | 8.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sc(F)c(F)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| 14325224 | 214770 | 5 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | CN(C)C(=O)CCS[C@@H](SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00172a025 | ||
| CHEMBL97257 | 214770 | 5 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | CN(C)C(=O)CCS[C@@H](SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00172a025 | ||
| 1836 | 9370 | 59 | None | -1 | 15 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/s0960-894x(98)00051-1 | ||
| 3340 | 9370 | 59 | None | -1 | 15 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/s0960-894x(98)00051-1 | ||
| 5281040 | 9370 | 59 | None | -1 | 15 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL787 | 9370 | 59 | None | -1 | 15 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/s0960-894x(98)00051-1 | ||
| DB00471 | 9370 | 59 | None | -1 | 15 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/s0960-894x(98)00051-1 | ||
| 10076489 | 215016 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 559 | 11 | 2 | 4 | 8.6 | CC(CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL98676 | 215016 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 559 | 11 | 2 | 4 | 8.6 | CC(CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | ||
| 10346 | 9337 | 46 | None | - | 1 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00099a011 | ||
| 5281888 | 9337 | 46 | None | - | 1 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00099a011 | ||
| CHEMBL15177 | 9337 | 46 | None | - | 1 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00099a011 | ||
| 44288159 | 170498 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 593 | 12 | 2 | 5 | 8.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(F)c(F)cc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL42051 | 170498 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 593 | 12 | 2 | 5 | 8.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(F)c(F)cc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44288695 | 175387 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 575 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL43602 | 175387 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 575 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44269325 | 21533 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 511 | 12 | 2 | 4 | 7.9 | C[C@H](CCC[C@@H](SCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1206456 | 21533 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 511 | 12 | 2 | 4 | 7.9 | C[C@H](CCC[C@@H](SCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL275823 | 21533 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 511 | 12 | 2 | 4 | 7.9 | C[C@H](CCC[C@@H](SCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 44269924 | 21538 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 587 | 13 | 2 | 7 | 7.2 | CCC(CSC(CCc1ccccc1-c1nn[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206475 | 21538 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 587 | 13 | 2 | 7 | 7.2 | CCC(CSC(CCc1ccccc1-c1nn[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL278210 | 21538 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 587 | 13 | 2 | 7 | 7.2 | CCC(CSC(CCc1ccccc1-c1nn[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 9829365 | 21368 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | CC(CSC(CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204692 | 21368 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | CC(CSC(CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15035 | 21368 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | CC(CSC(CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44269329 | 21638 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | C[C@H](CCC[C@@H](SCCC(=O)N(C)C)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1207565 | 21638 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | C[C@H](CCC[C@@H](SCCC(=O)N(C)C)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL415981 | 21638 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | C[C@H](CCC[C@@H](SCCC(=O)N(C)C)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 44269759 | 50949 | 0 | None | - | 1 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 587 | 13 | 2 | 4 | 9.2 | CCC[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15161 | 50949 | 0 | None | - | 1 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 587 | 13 | 2 | 4 | 9.2 | CCC[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 45268321 | 202350 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 615 | 9 | 1 | 5 | 7.8 | O=C(O)c1ccccc1OCCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL555048 | 202350 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 615 | 9 | 1 | 5 | 7.8 | O=C(O)c1ccccc1OCCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 19767793 | 105741 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 562 | 12 | 1 | 5 | 7.1 | CN(C)C(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15513 | 105741 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 562 | 12 | 1 | 5 | 7.1 | CN(C)C(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL279773 | 105741 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 562 | 12 | 1 | 5 | 7.1 | CN(C)C(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44461163 | 11727 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 561 | 8 | 3 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1c[nH]c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL1048 | 11727 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 561 | 8 | 3 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1c[nH]c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 44460797 | 211934 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 611 | 9 | 2 | 7 | 6.6 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(F)F)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL78140 | 211934 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 611 | 9 | 2 | 7 | 6.6 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(F)F)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 15872199 | 211935 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 589 | 9 | 2 | 8 | 5.2 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C=O)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL78141 | 211935 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 589 | 9 | 2 | 8 | 5.2 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C=O)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 2237 | 9936 | 79 | None | 4 | 3 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/jm970180w | ||
| 3634 | 9936 | 79 | None | 4 | 3 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/jm970180w | ||
| 4887 | 9936 | 79 | None | 4 | 3 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/jm970180w | ||
| CHEMBL21333 | 9936 | 79 | None | 4 | 3 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/jm970180w | ||
| DB01411 | 9936 | 79 | None | 4 | 3 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/jm970180w | ||
| 44250106 | 201952 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 523 | 7 | 1 | 4 | 6.5 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL550456 | 201952 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 523 | 7 | 1 | 4 | 6.5 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44288372 | 106915 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 617 | 14 | 2 | 5 | 9.3 | CC(CC(F)(F)F)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL287722 | 106915 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 617 | 14 | 2 | 5 | 9.3 | CC(CC(F)(F)F)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| 44269376 | 21366 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 587 | 12 | 2 | 4 | 9.5 | CC(C)(CC[C@@H](SCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1204690 | 21366 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 587 | 12 | 2 | 4 | 9.5 | CC(C)(CC[C@@H](SCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL14569 | 21366 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 587 | 12 | 2 | 4 | 9.5 | CC(C)(CC[C@@H](SCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 44361757 | 41186 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 573 | 12 | 2 | 4 | 8.5 | C[C@H](CS[C@@H](CCc1ccccc1CC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL142803 | 41186 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 573 | 12 | 2 | 4 | 8.5 | C[C@H](CS[C@@H](CCc1ccccc1CC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| 19767776 | 21639 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 542 | 12 | 1 | 4 | 8.1 | CCC(CSC(CCc1ccccc1C#N)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1207567 | 21639 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 542 | 12 | 1 | 4 | 8.1 | CCC(CSC(CCc1ccccc1C#N)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL416161 | 21639 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 542 | 12 | 1 | 4 | 8.1 | CCC(CSC(CCc1ccccc1C#N)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44270043 | 21372 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 597 | 13 | 1 | 6 | 7.4 | CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204696 | 21372 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 597 | 13 | 1 | 6 | 7.4 | CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15344 | 21372 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 597 | 13 | 1 | 6 | 7.4 | CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44269865 | 21541 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 7.7 | CCC(CSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206502 | 21541 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 7.7 | CCC(CSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL280260 | 21541 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 7.7 | CCC(CSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44320021 | 113878 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 637 | 12 | 2 | 5 | 9.8 | O=C(O)CC1(CS[C@H](CCc2ccccc2C2(O)CCC2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL315973 | 113878 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 637 | 12 | 2 | 5 | 9.8 | O=C(O)CC1(CS[C@H](CCc2ccccc2C2(O)CCC2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 44319783 | 113920 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 627 | 13 | 2 | 5 | 9.3 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(CCc2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL316170 | 113920 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 627 | 13 | 2 | 5 | 9.3 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(CCc2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| 44360625 | 39813 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 569 | 12 | 2 | 4 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCCC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL141640 | 39813 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 569 | 12 | 2 | 4 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCCC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| 15290705 | 113457 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL314340 | 113457 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| 45271665 | 202092 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 541 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCc2c(c3c(F)cccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL551520 | 202092 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 541 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCc2c(c3c(F)cccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 45268226 | 202845 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 545 | 7 | 1 | 6 | 6.2 | Clc1ccc2ccc(/C=C/c3cccc(Cn4c5c(c6ccccc64)CCN(CCc4nnn[nH]4)C5)c3)nc2c1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL560522 | 202845 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 545 | 7 | 1 | 6 | 6.2 | Clc1ccc2ccc(/C=C/c3cccc(Cn4c5c(c6ccccc64)CCN(CCc4nnn[nH]4)C5)c3)nc2c1 | 10.1016/j.bmcl.2009.05.094 | ||
| 45269111 | 203113 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 5 | 1 | 4 | 6.1 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(C#Cc3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL562383 | 203113 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 5 | 1 | 4 | 6.1 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(C#Cc3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44269323 | 21361 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 539 | 13 | 2 | 4 | 8.7 | CC(C)(O)CCCSC(CCC(C)(C)CC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1204684 | 21361 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 539 | 13 | 2 | 4 | 8.7 | CC(C)(O)CCCSC(CCC(C)(C)CC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL14180 | 21361 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 539 | 13 | 2 | 4 | 8.7 | CC(C)(O)CCCSC(CCC(C)(C)CC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80300-5 | ||
| 44269939 | 54759 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | CC(CCC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15500 | 54759 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | CC(CCC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| 44288695 | 175387 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 575 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL43602 | 175387 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 575 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44269368 | 21363 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 587 | 13 | 2 | 4 | 8.9 | CC(C)(O)c1ccccc1CS[C@@H](CCC1(CC(=O)O)CC1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1204687 | 21363 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 587 | 13 | 2 | 4 | 8.9 | CC(C)(O)c1ccccc1CS[C@@H](CCC1(CC(=O)O)CC1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL14408 | 21363 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 587 | 13 | 2 | 4 | 8.9 | CC(C)(O)c1ccccc1CS[C@@H](CCC1(CC(=O)O)CC1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80300-5 | ||
| 44269880 | 21649 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 716 | 15 | 2 | 7 | 8.4 | CCC(CSC(CCc1ccccc1C(=O)NS(=O)(=O)c1ccccc1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1207684 | 21649 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 716 | 15 | 2 | 7 | 8.4 | CCC(CSC(CCc1ccccc1C(=O)NS(=O)(=O)c1ccccc1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL429975 | 21649 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 716 | 15 | 2 | 7 | 8.4 | CCC(CSC(CCc1ccccc1C(=O)NS(=O)(=O)c1ccccc1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 10346 | 9337 | 46 | None | - | 1 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | ||
| 5281888 | 9337 | 46 | None | - | 1 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL15177 | 9337 | 46 | None | - | 1 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | ||
| 44288569 | 106985 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 561 | 12 | 2 | 5 | 8.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3c(s2)CCCC3)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL288369 | 106985 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 561 | 12 | 2 | 5 | 8.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3c(s2)CCCC3)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44269383 | 21529 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 532 | 12 | 1 | 4 | 8.3 | CC(C)(CC[C@H](SCc1ccccn1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1206441 | 21529 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 532 | 12 | 1 | 4 | 8.3 | CC(C)(CC[C@H](SCc1ccccn1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL274038 | 21529 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 532 | 12 | 1 | 4 | 8.3 | CC(C)(CC[C@H](SCc1ccccn1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 44319992 | 212949 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 567 | 11 | 1 | 4 | 9.4 | O=C(O)CC1(CS[C@H](CCc2ccccc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL86302 | 212949 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 567 | 11 | 1 | 4 | 9.4 | O=C(O)CC1(CS[C@H](CCc2ccccc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 44250107 | 202636 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 539 | 7 | 1 | 4 | 7.0 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL558638 | 202636 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 539 | 7 | 1 | 4 | 7.0 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44360675 | 39550 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 555 | 12 | 2 | 4 | 8.2 | CC1CCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL141405 | 39550 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 555 | 12 | 2 | 4 | 8.2 | CC1CCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21 | 10.1016/s0960-894x(98)00051-1 | ||
| 44288430 | 107913 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 547 | 13 | 2 | 5 | 8.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL295281 | 107913 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 547 | 13 | 2 | 5 | 8.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 2855 | 10904 | 104 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| 3322 | 10904 | 104 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| 5717 | 10904 | 104 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| CHEMBL603 | 10904 | 104 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| DB00549 | 10904 | 104 | None | 1 | 6 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| 2855 | 10904 | 104 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| 3322 | 10904 | 104 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| 5717 | 10904 | 104 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| CHEMBL603 | 10904 | 104 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| DB00549 | 10904 | 104 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| 2855 | 10904 | 104 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | ||
| 3322 | 10904 | 104 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | ||
| 5717 | 10904 | 104 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL603 | 10904 | 104 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | ||
| DB00549 | 10904 | 104 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | ||
| 44288716 | 168935 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 549 | 13 | 2 | 5 | 8.3 | CC(C)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL41620 | 168935 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 549 | 13 | 2 | 5 | 8.3 | CC(C)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| 44269345 | 21364 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 589 | 13 | 2 | 4 | 9.2 | CC(C)(CC[C@@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1204688 | 21364 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 589 | 13 | 2 | 4 | 9.2 | CC(C)(CC[C@@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL14450 | 21364 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 589 | 13 | 2 | 4 | 9.2 | CC(C)(CC[C@@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 19767879 | 174406 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 562 | 12 | 1 | 5 | 7.1 | CN(C)C(=O)CCSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL430147 | 174406 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 562 | 12 | 1 | 5 | 7.1 | CN(C)C(=O)CCSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 9829999 | 212760 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3scc(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL84707 | 212760 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3scc(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| 44274381 | 86792 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 540 | 17 | 3 | 6 | 6.8 | CCCCC/C=C/C/C=C\C=C\C=C\[C@@H](Sc1ccc2c(=O)cc(C(=O)O)oc2c1)[C@H](O)CCCC(=O)O | 10.1021/jm00108a001 | ||
| CHEMBL21286 | 86792 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 540 | 17 | 3 | 6 | 6.8 | CCCCC/C=C/C/C=C\C=C\C=C\[C@@H](Sc1ccc2c(=O)cc(C(=O)O)oc2c1)[C@H](O)CCCC(=O)O | 10.1021/jm00108a001 | ||
| 6518171 | 175075 | 55 | None | -4 | 8 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 495 | 12 | 2 | 6 | 4.9 | CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 | nan | ||
| CHEMBL434063 | 175075 | 55 | None | -4 | 8 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 495 | 12 | 2 | 6 | 4.9 | CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 | nan | ||
| 44288480 | 172744 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 583 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccccc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL42520 | 172744 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 583 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccccc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44288324 | 168541 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 625 | 12 | 2 | 5 | 9.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(C(F)(F)F)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL41395 | 168541 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 625 | 12 | 2 | 5 | 9.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(C(F)(F)F)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 45270816 | 203533 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 527 | 7 | 1 | 5 | 7.0 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3nc4cc(Cl)ccc4s3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL565228 | 203533 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 527 | 7 | 1 | 5 | 7.0 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3nc4cc(Cl)ccc4s3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 45270799 | 201818 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 523 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCC2C(C1)c1ccccc1N2Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL549431 | 201818 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 523 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCC2C(C1)c1ccccc1N2Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44288249 | 166040 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 8.6 | Cc1sc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C(C)C | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL40992 | 166040 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 8.6 | Cc1sc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C(C)C | 10.1016/0960-894X(95)00265-U | ||
| 10051321 | 23677 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 491 | 12 | 2 | 6 | 5.9 | O=C(O)CCSC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL125135 | 23677 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 491 | 12 | 2 | 6 | 5.9 | O=C(O)CCSC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| 44288613 | 164616 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 613 | 14 | 2 | 6 | 8.9 | COc1ccc(-c2csc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)n2)cc1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL40836 | 164616 | 0 | None | - | 0 | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 613 | 14 | 2 | 6 | 8.9 | COc1ccc(-c2csc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)n2)cc1 | 10.1016/0960-894X(95)00265-U | ||
| 45268266 | 202775 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 535 | 6 | 1 | 5 | 7.1 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2ccc3oc(-c4ccc5ccc(Cl)cc5n4)cc3c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL559928 | 202775 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 535 | 6 | 1 | 5 | 7.1 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2ccc3oc(-c4ccc5ccc(Cl)cc5n4)cc3c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 15289799 | 105435 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 518 | 12 | 1 | 6 | 5.9 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL277332 | 105435 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 518 | 12 | 1 | 6 | 5.9 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 45273388 | 202500 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 537 | 8 | 1 | 4 | 7.1 | O=C(O)CCCN1CCC2c3ccccc3N(Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)C2C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL557105 | 202500 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 537 | 8 | 1 | 4 | 7.1 | O=C(O)CCCN1CCC2c3ccccc3N(Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)C2C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44288614 | 103253 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 601 | 13 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(F)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL262391 | 103253 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 601 | 13 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(F)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44319586 | 212584 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 639 | 12 | 2 | 5 | 9.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(C2CC2c2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL83233 | 212584 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 639 | 12 | 2 | 5 | 9.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(C2CC2c2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| 45273411 | 201682 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 565 | 9 | 1 | 5 | 7.3 | CCOc1cccc2c3c(n(Cc4cccc(/C=C/c5ccc6ccc(Cl)cc6n5)c4)c12)CCN(CCC(=O)O)C3 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL541010 | 201682 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 565 | 9 | 1 | 5 | 7.3 | CCOc1cccc2c3c(n(Cc4cccc(/C=C/c5ccc6ccc(Cl)cc6n5)c4)c12)CCN(CCC(=O)O)C3 | 10.1016/j.bmcl.2009.05.094 | ||
| 10744393 | 78239 | 0 | None | - | 1 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 514 | 8 | 2 | 5 | 4.7 | O=C(N[C@H](CN1CCC(OC2c3ccccc3CCc3ccccc32)CC1)C(=O)O)OCc1ccccc1 | 10.1021/jm058225d | ||
| CHEMBL196220 | 78239 | 0 | None | - | 1 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 514 | 8 | 2 | 5 | 4.7 | O=C(N[C@H](CN1CCC(OC2c3ccccc3CCc3ccccc32)CC1)C(=O)O)OCc1ccccc1 | 10.1021/jm058225d | ||
| 45268250 | 203103 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 551 | 8 | 1 | 5 | 6.9 | COc1ccc2c3c(n(Cc4cccc(/C=C/c5ccc6ccc(Cl)cc6n5)c4)c2c1)CCN(CCC(=O)O)C3 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL562324 | 203103 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 551 | 8 | 1 | 5 | 6.9 | COc1ccc2c3c(n(Cc4cccc(/C=C/c5ccc6ccc(Cl)cc6n5)c4)c2c1)CCN(CCC(=O)O)C3 | 10.1016/j.bmcl.2009.05.094 | ||
| 45270063 | 203201 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 549 | 9 | 1 | 4 | 7.7 | O=C(O)CCCCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL562906 | 203201 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 549 | 9 | 1 | 4 | 7.7 | O=C(O)CCCCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 45269186 | 203498 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 521 | 7 | 1 | 4 | 6.9 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL564954 | 203498 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 521 | 7 | 1 | 4 | 6.9 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 9829198 | 168085 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 557 | 12 | 2 | 5 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3ccccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL41230 | 168085 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 557 | 12 | 2 | 5 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3ccccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 10526098 | 106475 | 1 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970180w | ||
| CHEMBL284624 | 106475 | 1 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970180w | ||
| 10574284 | 123751 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970180w | ||
| CHEMBL33871 | 123751 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970180w | ||
| 45270876 | 201953 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 507 | 6 | 1 | 4 | 6.5 | O=C(O)CN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL550458 | 201953 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 507 | 6 | 1 | 4 | 6.5 | O=C(O)CN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 22848883 | 21531 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206448 | 21531 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL274913 | 21531 | 0 | None | - | 1 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44288589 | 108196 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 583 | 13 | 2 | 5 | 9.0 | CC(C)c1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)sc1Cl | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL297396 | 108196 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 583 | 13 | 2 | 5 | 9.0 | CC(C)c1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)sc1Cl | 10.1016/0960-894X(95)00265-U | ||
| 448537 | 167029 | 89 | None | -41 | 25 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | nan | ||
| CHEMBL411 | 167029 | 89 | None | -41 | 25 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | nan | ||
| 44288589 | 108196 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 583 | 13 | 2 | 5 | 9.0 | CC(C)c1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)sc1Cl | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL297396 | 108196 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 583 | 13 | 2 | 5 | 9.0 | CC(C)c1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)sc1Cl | 10.1016/0960-894X(95)00265-U | ||
| 2855 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00442-9 | ||
| 3322 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00442-9 | ||
| 5717 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL603 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00442-9 | ||
| DB00549 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00442-9 | ||
| 9853580 | 112925 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 756 | 10 | 2 | 8 | 9.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(c2ccccc2)c2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| CHEMBL313567 | 112925 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 756 | 10 | 2 | 8 | 9.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(c2ccccc2)c2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | ||
| 44360640 | 38309 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 569 | 12 | 2 | 4 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)C(C)(C)CC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL140381 | 38309 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 569 | 12 | 2 | 4 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)C(C)(C)CC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| 44288735 | 168956 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 8.5 | CC(C)(C)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL416249 | 168956 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 8.5 | CC(C)(C)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| 44269386 | 21641 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 511 | 12 | 2 | 4 | 7.9 | C[C@H](CCC[C@H](SCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1207573 | 21641 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 511 | 12 | 2 | 4 | 7.9 | C[C@H](CCC[C@H](SCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL416344 | 21641 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 511 | 12 | 2 | 4 | 7.9 | C[C@H](CCC[C@H](SCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 44361753 | 40716 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 529 | 11 | 1 | 4 | 8.0 | C[C@H](CS[C@@H](CCc1ccccc1C=O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL142395 | 40716 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 529 | 11 | 1 | 4 | 8.0 | C[C@H](CS[C@@H](CCc1ccccc1C=O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| 22848869 | 21371 | 0 | None | - | 1 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204695 | 21371 | 0 | None | - | 1 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15306 | 21371 | 0 | None | - | 1 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44269865 | 21541 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 7.7 | CCC(CSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206502 | 21541 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 7.7 | CCC(CSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL280260 | 21541 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 7.7 | CCC(CSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44319587 | 212870 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 629 | 13 | 2 | 6 | 9.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(OCc2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL85633 | 212870 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 629 | 13 | 2 | 6 | 9.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(OCc2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| 44288714 | 161925 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 589 | 13 | 2 | 5 | 9.3 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCCCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL40213 | 161925 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 589 | 13 | 2 | 5 | 9.3 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCCCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44361755 | 42190 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 531 | 11 | 2 | 4 | 7.7 | C[C@H](CS[C@@H](CCc1cccc(CO)c1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL143788 | 42190 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 531 | 11 | 2 | 4 | 7.7 | C[C@H](CS[C@@H](CCc1cccc(CO)c1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| 44319872 | 213173 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 585 | 11 | 1 | 4 | 9.6 | O=C(O)CC1(CS[C@H](CCc2ccc(F)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL87696 | 213173 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 585 | 11 | 1 | 4 | 9.6 | O=C(O)CC1(CS[C@H](CCc2ccc(F)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 9985190 | 164951 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 556 | 11 | 1 | 6 | 6.2 | O=C(O)CCSC(SCCC(=O)N1CCOCC1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL408753 | 164951 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 556 | 11 | 1 | 6 | 6.2 | O=C(O)CCSC(SCCC(=O)N1CCOCC1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| 44269370 | 21534 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 546 | 13 | 1 | 4 | 8.4 | CC(C)(CC[C@H](SCCc1ccccn1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1206457 | 21534 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 546 | 13 | 1 | 4 | 8.4 | CC(C)(CC[C@H](SCCc1ccccn1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL276036 | 21534 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 546 | 13 | 1 | 4 | 8.4 | CC(C)(CC[C@H](SCCc1ccccn1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 1836 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| 3340 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| 5281040 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| CHEMBL787 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| DB00471 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| 1836 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.5b00741 | ||
| 3340 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.5b00741 | ||
| 5281040 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL787 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.5b00741 | ||
| DB00471 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.5b00741 | ||
| 15859378 | 118313 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 573 | 11 | 2 | 4 | 8.8 | C[C@H](S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)[C@@H](C)C(=O)O | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL327942 | 118313 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 573 | 11 | 2 | 4 | 8.8 | C[C@H](S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)[C@@H](C)C(=O)O | 10.1016/0960-894X(95)00023-M | ||
| 44269352 | 21542 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | C[C@H](CCC[C@H](SCCC(=O)N(C)C)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL1206504 | 21542 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | C[C@H](CCC[C@H](SCCC(=O)N(C)C)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| CHEMBL280298 | 21542 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | C[C@H](CCC[C@H](SCCC(=O)N(C)C)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | ||
| 1836 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b01287 | ||
| 3340 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b01287 | ||
| 5281040 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b01287 | ||
| CHEMBL787 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b01287 | ||
| DB00471 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b01287 | ||
| 44319978 | 212860 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 645 | 11 | 1 | 4 | 10.2 | O=C(O)CC1(CS[C@H](CCc2ccccc2Br)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL85572 | 212860 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 645 | 11 | 1 | 4 | 10.2 | O=C(O)CC1(CS[C@H](CCc2ccccc2Br)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 10346 | 9337 | 46 | None | - | 1 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | ||
| 5281888 | 9337 | 46 | None | - | 1 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL15177 | 9337 | 46 | None | - | 1 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | ||
| 45269140 | 202966 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 541 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCc2c(c3cc(F)ccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL561381 | 202966 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 541 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCc2c(c3cc(F)ccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 15859367 | 42285 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 559 | 11 | 2 | 4 | 8.4 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL143874 | 42285 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 559 | 11 | 2 | 4 | 8.4 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| 44360644 | 37956 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 559 | 12 | 2 | 5 | 7.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCS3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL140058 | 37956 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 559 | 12 | 2 | 5 | 7.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCS3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| 45272522 | 202564 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 523 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCC2c3ccccc3N(Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)C2C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL557850 | 202564 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 523 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCC2c3ccccc3N(Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)C2C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 22848883 | 21531 | 0 | None | - | 1 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206448 | 21531 | 0 | None | - | 1 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL274913 | 21531 | 0 | None | - | 1 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 14541296 | 201773 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 540 | 15 | 2 | 7 | 6.3 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(CCC)(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| CHEMBL54744 | 201773 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 540 | 15 | 2 | 7 | 6.3 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(CCC)(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| 45268240 | 202992 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 555 | 7 | 1 | 4 | 7.5 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(Cl)c(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL561524 | 202992 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 555 | 7 | 1 | 4 | 7.5 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(Cl)c(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 128355 | 10441 | 30 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm00108a001 | ||
| 3329 | 10441 | 30 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm00108a001 | ||
| CHEMBL18132 | 10441 | 30 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm00108a001 | ||
| 128355 | 10441 | 30 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm00166a017 | ||
| 3329 | 10441 | 30 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm00166a017 | ||
| CHEMBL18132 | 10441 | 30 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm00166a017 | ||
| 13997664 | 67117 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 405 | 8 | 2 | 4 | 4.9 | CCCCCc1ccc(/C=C/C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/acs.jmedchem.6b01287 | ||
| CHEMBL174483 | 67117 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 405 | 8 | 2 | 4 | 4.9 | CCCCCc1ccc(/C=C/C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/acs.jmedchem.6b01287 | ||
| 45270792 | 203150 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 523 | 8 | 1 | 4 | 6.5 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(CCc3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL562575 | 203150 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 523 | 8 | 1 | 4 | 6.5 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(CCc3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 10097610 | 21577 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 503 | 13 | 2 | 5 | 6.5 | O=C(O)CCSC(SCCC(=O)O)c1cccc(CCCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL1207034 | 21577 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 503 | 13 | 2 | 5 | 6.5 | O=C(O)CCSC(SCCC(=O)O)c1cccc(CCCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL339713 | 21577 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 503 | 13 | 2 | 5 | 6.5 | O=C(O)CCSC(SCCC(=O)O)c1cccc(CCCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| 45273491 | 202574 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 535 | 6 | 1 | 4 | 6.4 | O=C(O)CC(=O)N1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL557924 | 202574 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 535 | 6 | 1 | 4 | 6.4 | O=C(O)CC(=O)N1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 19930521 | 53633 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 516 | 12 | 1 | 5 | 6.1 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15405 | 53633 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 516 | 12 | 1 | 5 | 6.1 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 5352624 | 74013 | 44 | None | -4 | 5 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 340 | 4 | 1 | 2 | 5.4 | CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1 | nan | ||
| CHEMBL18797 | 74013 | 44 | None | -4 | 5 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 340 | 4 | 1 | 2 | 5.4 | CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1 | nan | ||
| 45270885 | 202385 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 585 | 7 | 1 | 4 | 7.9 | O=C(O)c1ccc(CN2CCc3c(c4ccccc4n3Cc3cccc(/C=C/c4ccc5cc(F)c(F)cc5n4)c3)C2)cc1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL555910 | 202385 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 585 | 7 | 1 | 4 | 7.9 | O=C(O)c1ccc(CN2CCc3c(c4ccccc4n3Cc3cccc(/C=C/c4ccc5cc(F)c(F)cc5n4)c3)C2)cc1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44288196 | 175709 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 547 | 12 | 2 | 5 | 7.7 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3c(s2)CCC3)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL43874 | 175709 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 547 | 12 | 2 | 5 | 7.7 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3c(s2)CCC3)c1 | 10.1016/0960-894X(95)00265-U | ||
| 9829423 | 39325 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 543 | 11 | 1 | 4 | 8.4 | CC(=O)c1ccccc1CC[C@H](SC[C@@H](C)C(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL141233 | 39325 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 543 | 11 | 1 | 4 | 8.4 | CC(=O)c1ccccc1CC[C@H](SC[C@@H](C)C(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| 10346 | 9337 | 46 | None | - | 1 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| 5281888 | 9337 | 46 | None | - | 1 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15177 | 9337 | 46 | None | - | 1 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| 6193 | 10756 | 38 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm960088k | ||
| 6509849 | 10756 | 38 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm960088k | ||
| CHEMBL280481 | 10756 | 38 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm960088k | ||
| 6193 | 10756 | 38 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | ||
| 6509849 | 10756 | 38 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | ||
| CHEMBL280481 | 10756 | 38 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | ||
| 6193 | 10756 | 38 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/acs.jmedchem.6b00472 | ||
| 6509849 | 10756 | 38 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/acs.jmedchem.6b00472 | ||
| CHEMBL280481 | 10756 | 38 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/acs.jmedchem.6b00472 | ||
| 14325224 | 214770 | 5 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | CN(C)C(=O)CCS[C@@H](SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00172a025 | ||
| CHEMBL97257 | 214770 | 5 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | CN(C)C(=O)CCS[C@@H](SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00172a025 | ||
| 44361773 | 39837 | 1 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 531 | 11 | 2 | 4 | 7.7 | C[C@H](CS[C@@H](CCc1ccccc1CO)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL141665 | 39837 | 1 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 531 | 11 | 2 | 4 | 7.7 | C[C@H](CS[C@@H](CCc1ccccc1CO)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| 6193 | 10756 | 38 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | ||
| 6509849 | 10756 | 38 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | ||
| CHEMBL280481 | 10756 | 38 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | ||
| 45273490 | 202310 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 561 | 8 | 1 | 4 | 7.7 | O=C(O)CC1(CN2CCc3c(c4ccccc4n3Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)C2)CC1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL554154 | 202310 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 561 | 8 | 1 | 4 | 7.7 | O=C(O)CC1(CN2CCc3c(c4ccccc4n3Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)C2)CC1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44288430 | 107913 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 547 | 13 | 2 | 5 | 8.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL295281 | 107913 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 547 | 13 | 2 | 5 | 8.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44288735 | 168956 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 8.5 | CC(C)(C)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL416249 | 168956 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 8.5 | CC(C)(C)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | ||
| 9959856 | 175240 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 575 | 12 | 2 | 5 | 8.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(F)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL43509 | 175240 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 575 | 12 | 2 | 5 | 8.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(F)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44319827 | 213152 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 635 | 11 | 1 | 4 | 10.5 | O=C(O)CC1(CS[C@H](CCc2ccccc2C(F)(F)F)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL87528 | 213152 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 635 | 11 | 1 | 4 | 10.5 | O=C(O)CC1(CS[C@H](CCc2ccccc2C(F)(F)F)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 45272532 | 202619 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 505 | 7 | 1 | 4 | 6.4 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL558443 | 202619 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 505 | 7 | 1 | 4 | 6.4 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 45268232 | 202949 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 494 | 8 | 1 | 3 | 7.8 | Cc1c(CCCC(=O)O)c2ccccc2n1Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL561321 | 202949 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 494 | 8 | 1 | 3 | 7.8 | Cc1c(CCCC(=O)O)c2ccccc2n1Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44269922 | 105333 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 592 | 13 | 2 | 6 | 6.6 | CC(CSC(CCc1ccccc1C(=O)N(C)CO)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL276584 | 105333 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 592 | 13 | 2 | 6 | 6.6 | CC(CSC(CCc1ccccc1C(=O)N(C)CO)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44361485 | 42065 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 557 | 12 | 1 | 4 | 8.8 | CCC(=O)c1ccccc1CC[C@H](SC[C@@H](C)C(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL143639 | 42065 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 557 | 12 | 1 | 4 | 8.8 | CCC(=O)c1ccccc1CC[C@H](SC[C@@H](C)C(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| 44361525 | 126193 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 573 | 12 | 1 | 5 | 8.4 | CCOC(=O)c1ccccc1CC[C@H](SC[C@@H](C)C(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL344756 | 126193 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 573 | 12 | 1 | 5 | 8.4 | CCOC(=O)c1ccccc1CC[C@H](SC[C@@H](C)C(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| 6193 | 10756 | 38 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00265-U | ||
| 6509849 | 10756 | 38 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL280481 | 10756 | 38 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00265-U | ||
| 10346 | 9337 | 46 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| 5281888 | 9337 | 46 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15177 | 9337 | 46 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| 137660132 | 166298 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 429 | 8 | 1 | 7 | 4.2 | CCCCCc1ccc(/C=C/C(=O)Nc2cccc3c(=O)cc(-n4cnnn4)oc23)cc1 | 10.1021/acs.jmedchem.6b01287 | ||
| CHEMBL4102154 | 166298 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 429 | 8 | 1 | 7 | 4.2 | CCCCCc1ccc(/C=C/C(=O)Nc2cccc3c(=O)cc(-n4cnnn4)oc23)cc1 | 10.1021/acs.jmedchem.6b01287 | ||
| 45269187 | 202830 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 535 | 8 | 1 | 4 | 7.3 | O=C(O)CCCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL560385 | 202830 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 535 | 8 | 1 | 4 | 7.3 | O=C(O)CCCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 10391331 | 176859 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 11 | 2 | 5 | 6.6 | O=C(O)CCSC(SCCC(=O)O)c1cccc(C2CC2c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL444331 | 176859 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 11 | 2 | 5 | 6.6 | O=C(O)CCSC(SCCC(=O)O)c1cccc(C2CC2c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| 10399041 | 123784 | 2 | None | - | 0 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 232 | 2 | 0 | 2 | 3.8 | C(=C/c1ccc2ccccc2n1)\c1ccncc1 | 10.1021/jm00099a011 | ||
| CHEMBL338876 | 123784 | 2 | None | - | 0 | Guinea pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 232 | 2 | 0 | 2 | 3.8 | C(=C/c1ccc2ccccc2n1)\c1ccncc1 | 10.1021/jm00099a011 | ||
| 2812 | 11551 | 101 | None | -58 | 34 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
| CHEMBL104 | 11551 | 101 | None | -58 | 34 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
| 19930521 | 53633 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 516 | 12 | 1 | 5 | 6.1 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15405 | 53633 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 516 | 12 | 1 | 5 | 6.1 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 45270815 | 201981 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 499 | 7 | 1 | 5 | 6.4 | CC(C)(C)c1csc(/C=C/c2cccc(Cn3c4c(c5ccccc53)CN(CCC(=O)O)CC4)c2)n1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL550654 | 201981 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 499 | 7 | 1 | 5 | 6.4 | CC(C)(C)c1csc(/C=C/c2cccc(Cn3c4c(c5ccccc53)CN(CCC(=O)O)CC4)c2)n1 | 10.1016/j.bmcl.2009.05.094 | ||
| 9871637 | 168751 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 507 | 12 | 2 | 5 | 7.2 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nccs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL415903 | 168751 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 507 | 12 | 2 | 5 | 7.2 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nccs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 22848869 | 21371 | 0 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204695 | 21371 | 0 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15306 | 21371 | 0 | None | - | 1 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 45268320 | 203143 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 533 | 7 | 1 | 4 | 7.1 | O=C(O)/C=C/CN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL562524 | 203143 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 533 | 7 | 1 | 4 | 7.1 | O=C(O)/C=C/CN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 2237 | 9936 | 79 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | ||
| 3634 | 9936 | 79 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | ||
| 4887 | 9936 | 79 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | ||
| CHEMBL21333 | 9936 | 79 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | ||
| DB01411 | 9936 | 79 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | ||
| 44361688 | 21657 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 605 | 12 | 1 | 4 | 9.4 | C[C@H](CS[C@@H](CCc1ccccc1C(=O)c1ccccc1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL120779 | 21657 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 605 | 12 | 1 | 4 | 9.4 | C[C@H](CS[C@@H](CCc1ccccc1C(=O)c1ccccc1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | ||
| 45271634 | 201865 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 480 | 8 | 1 | 3 | 7.5 | O=C(O)CCCc1cn(Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL549700 | 201865 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 480 | 8 | 1 | 3 | 7.5 | O=C(O)CCCc1cn(Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 | 10.1016/j.bmcl.2009.05.094 | ||
| 2237 | 9936 | 79 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| 3634 | 9936 | 79 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| 4887 | 9936 | 79 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| CHEMBL21333 | 9936 | 79 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| DB01411 | 9936 | 79 | None | -4 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | ||
| 45272547 | 202425 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 541 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCc2c(c3ccc(F)cc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL556420 | 202425 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 541 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCc2c(c3ccc(F)cc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44288196 | 175709 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 547 | 12 | 2 | 5 | 7.7 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3c(s2)CCC3)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL43874 | 175709 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 547 | 12 | 2 | 5 | 7.7 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3c(s2)CCC3)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44319977 | 212535 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 645 | 11 | 1 | 4 | 10.2 | O=C(O)CC1(CS[C@H](CCc2ccc(Br)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL82790 | 212535 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 645 | 11 | 1 | 4 | 10.2 | O=C(O)CC1(CS[C@H](CCc2ccc(Br)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 45273394 | 203206 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 516 | 7 | 1 | 3 | 8.2 | O=C(O)CCc1ccc2c(c1)c1ccccc1n2Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL562930 | 203206 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 516 | 7 | 1 | 3 | 8.2 | O=C(O)CCc1ccc2c(c1)c1ccccc1n2Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/j.bmcl.2009.05.094 | ||
| 45267392 | 203476 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 506 | 6 | 1 | 3 | 7.6 | O=C(O)CC1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL564798 | 203476 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 506 | 6 | 1 | 3 | 7.6 | O=C(O)CC1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 57109 | 90258 | 25 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | ||
| CHEMBL22016 | 90258 | 25 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | ||
| 105007 | 103875 | 32 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm960088k | ||
| CHEMBL267475 | 103875 | 32 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm960088k | ||
| CHEMBL267976 | 103875 | 32 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm960088k | ||
| 57109 | 90258 | 25 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| CHEMBL22016 | 90258 | 25 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| 45271619 | 202152 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 525 | 8 | 1 | 5 | 6.3 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(OCc3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL551923 | 202152 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 525 | 8 | 1 | 5 | 6.3 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(OCc3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44288373 | 163356 | 1 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 629 | 15 | 2 | 6 | 9.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(CSc3ccccc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL40686 | 163356 | 1 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 629 | 15 | 2 | 6 | 9.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(CSc3ccccc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 2855 | 10904 | 104 | None | -1 | 6 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00137-1 | ||
| 3322 | 10904 | 104 | None | -1 | 6 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00137-1 | ||
| 5717 | 10904 | 104 | None | -1 | 6 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00137-1 | ||
| CHEMBL603 | 10904 | 104 | None | -1 | 6 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00137-1 | ||
| DB00549 | 10904 | 104 | None | -1 | 6 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00137-1 | ||
| 10073436 | 21355 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 470 | 11 | 3 | 6 | 4.9 | O=C(O)CCSC(SCCC(=O)O)c1cccc(NC(=O)c2ccc3ccccc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL1204572 | 21355 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 470 | 11 | 3 | 6 | 4.9 | O=C(O)CCSC(SCCC(=O)O)c1cccc(NC(=O)c2ccc3ccccc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL338166 | 21355 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 470 | 11 | 3 | 6 | 4.9 | O=C(O)CCSC(SCCC(=O)O)c1cccc(NC(=O)c2ccc3ccccc3n2)c1 | 10.1021/jm00099a011 | ||
| 44288320 | 172299 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 587 | 13 | 2 | 6 | 8.4 | COc1ccc2nc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)sc2c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL42410 | 172299 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 587 | 13 | 2 | 6 | 8.4 | COc1ccc2nc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)sc2c1 | 10.1016/0960-894X(95)00265-U | ||
| 44360844 | 126573 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 583 | 12 | 2 | 4 | 8.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)C(C)(C)CCC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| CHEMBL348229 | 126573 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 583 | 12 | 2 | 4 | 8.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)C(C)(C)CCC3)c1 | 10.1016/s0960-894x(98)00051-1 | ||
| 22848881 | 21537 | 0 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206471 | 21537 | 0 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL277533 | 21537 | 0 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44288249 | 166040 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 8.6 | Cc1sc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C(C)C | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL40992 | 166040 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 563 | 13 | 2 | 5 | 8.6 | Cc1sc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C(C)C | 10.1016/0960-894X(95)00265-U | ||
| 44361742 | 41189 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 543 | 11 | 1 | 4 | 8.4 | CC(=O)c1cccc(CC[C@H](SC[C@@H](C)C(=O)O)c2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL142805 | 41189 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 543 | 11 | 1 | 4 | 8.4 | CC(=O)c1cccc(CC[C@H](SC[C@@H](C)C(=O)O)c2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| 45273410 | 203408 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 561 | 7 | 1 | 5 | 7.6 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL564275 | 203408 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 561 | 7 | 1 | 5 | 7.6 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 14329740 | 201841 | 2 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CC[C@@H](C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| CHEMBL54955 | 201841 | 2 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CC[C@@H](C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| 14329749 | 201458 | 0 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 512 | 14 | 2 | 7 | 5.5 | CCCc1c(OCCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| CHEMBL53252 | 201458 | 0 | None | - | 0 | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 512 | 14 | 2 | 7 | 5.5 | CCCc1c(OCCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| 10413257 | 23275 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 12 | 2 | 5 | 6.1 | O=C(O)CCSC(SCCC(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL123623 | 23275 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 12 | 2 | 5 | 6.1 | O=C(O)CCSC(SCCC(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| 9888588 | 69300 | 4 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 424 | 9 | 2 | 4 | 5.2 | CCC(CC)(CC(=O)Nc1cccc(OCc2ccc3ccc(F)cc3n2)c1)C(=O)O | 10.1016/s0960-894x(98)00137-1 | ||
| CHEMBL178221 | 69300 | 4 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 424 | 9 | 2 | 4 | 5.2 | CCC(CC)(CC(=O)Nc1cccc(OCc2ccc3ccc(F)cc3n2)c1)C(=O)O | 10.1016/s0960-894x(98)00137-1 | ||
| 44288180 | 151365 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(Cl)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL39077 | 151365 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(Cl)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44269986 | 21374 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 547 | 12 | 1 | 4 | 8.7 | CC(CSC(CCc1ccccc1C(C)C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204698 | 21374 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 547 | 12 | 1 | 4 | 8.7 | CC(CSC(CCc1ccccc1C(C)C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15419 | 21374 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 547 | 12 | 1 | 4 | 8.7 | CC(CSC(CCc1ccccc1C(C)C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44319716 | 112769 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 733 | 12 | 2 | 5 | 10.7 | O=C(O)CC1(CS[C@H](CCc2ccccc2C(O)(C(F)(F)F)C(F)(F)F)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL313177 | 112769 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 733 | 12 | 2 | 5 | 10.7 | O=C(O)CC1(CS[C@H](CCc2ccccc2C(O)(C(F)(F)F)C(F)(F)F)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 44270014 | 21375 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 491 | 11 | 1 | 4 | 7.3 | O=C(O)CCSC(CCc1ccccc1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1204699 | 21375 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 491 | 11 | 1 | 4 | 7.3 | O=C(O)CCSC(CCc1ccccc1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15481 | 21375 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 491 | 11 | 1 | 4 | 7.3 | O=C(O)CCSC(CCc1ccccc1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44269880 | 21649 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 716 | 15 | 2 | 7 | 8.4 | CCC(CSC(CCc1ccccc1C(=O)NS(=O)(=O)c1ccccc1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1207684 | 21649 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 716 | 15 | 2 | 7 | 8.4 | CCC(CSC(CCc1ccccc1C(=O)NS(=O)(=O)c1ccccc1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL429975 | 21649 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 716 | 15 | 2 | 7 | 8.4 | CCC(CSC(CCc1ccccc1C(=O)NS(=O)(=O)c1ccccc1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 44288614 | 103253 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 601 | 13 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(F)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL262391 | 103253 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 601 | 13 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(F)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44288480 | 172744 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 583 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccccc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL42520 | 172744 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 583 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccccc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44350320 | 23444 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 486 | 11 | 1 | 5 | 6.6 | CN(C)CCSC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL124259 | 23444 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 486 | 11 | 1 | 5 | 6.6 | CN(C)CCSC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | ||
| 5357469 | 25326 | 25 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 231 | 2 | 0 | 1 | 4.4 | C(=C/c1ccc2ccccc2n1)\c1ccccc1 | 10.1021/jm00099a011 | ||
| CHEMBL127579 | 25326 | 25 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 231 | 2 | 0 | 1 | 4.4 | C(=C/c1ccc2ccccc2n1)\c1ccccc1 | 10.1021/jm00099a011 | ||
| 5376707 | 25573 | 16 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 232 | 2 | 0 | 2 | 3.8 | C(=C/c1ccc2ccccc2n1)\c1cccnc1 | 10.1021/jm00099a011 | ||
| CHEMBL127816 | 25573 | 16 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 232 | 2 | 0 | 2 | 3.8 | C(=C/c1ccc2ccccc2n1)\c1cccnc1 | 10.1021/jm00099a011 | ||
| 14329737 | 202533 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 470 | 11 | 2 | 7 | 4.4 | CCCc1c(OCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| CHEMBL55750 | 202533 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 470 | 11 | 2 | 7 | 4.4 | CCCc1c(OCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| 45267388 | 203243 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 509 | 9 | 1 | 4 | 7.0 | CN(CCC(=O)O)Cc1cn(Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL563165 | 203243 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 509 | 9 | 1 | 4 | 7.0 | CN(CCC(=O)O)Cc1cn(Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 | 10.1016/j.bmcl.2009.05.094 | ||
| 22416877 | 67199 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 440 | 9 | 2 | 4 | 5.7 | CCC(CC)(CC(=O)Nc1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/s0960-894x(98)00137-1 | ||
| CHEMBL175119 | 67199 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 440 | 9 | 2 | 4 | 5.7 | CCC(CC)(CC(=O)Nc1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/s0960-894x(98)00137-1 | ||
| 5280878 | 107049 | 27 | None | 2 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/j.bmc.2010.07.034 | ||
| CHEMBL288943 | 107049 | 27 | None | 2 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/j.bmc.2010.07.034 | ||
| 44361511 | 40984 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 559 | 11 | 1 | 5 | 8.0 | COC(=O)c1cccc(CC[C@H](SC[C@@H](C)C(=O)O)c2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| CHEMBL142627 | 40984 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 559 | 11 | 1 | 5 | 8.0 | COC(=O)c1cccc(CC[C@H](SC[C@@H](C)C(=O)O)c2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c1 | 10.1016/0960-894X(94)80017-0 | ||
| 22848881 | 21537 | 0 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL1206471 | 21537 | 0 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL277533 | 21537 | 0 | None | - | 1 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | ||
| 45270818 | 202005 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 551 | 8 | 1 | 5 | 6.9 | COc1ccc2c(c1)c1c(n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)CCN(CCC(=O)O)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL550859 | 202005 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 551 | 8 | 1 | 5 | 6.9 | COc1ccc2c(c1)c1c(n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)CCN(CCC(=O)O)C1 | 10.1016/j.bmcl.2009.05.094 | ||
| 44288324 | 168541 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 625 | 12 | 2 | 5 | 9.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(C(F)(F)F)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL41395 | 168541 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 625 | 12 | 2 | 5 | 9.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(C(F)(F)F)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 44288180 | 151365 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(Cl)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL39077 | 151365 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(Cl)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 14541261 | 196945 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 532 | 11 | 2 | 7 | 5.7 | CCCc1c(OCc2cccc(COc3cc4c(cc3C(C)=O)CCC(C(=O)O)O4)c2)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| CHEMBL51739 | 196945 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 532 | 11 | 2 | 7 | 5.7 | CCCc1c(OCc2cccc(COc3cc4c(cc3C(C)=O)CCC(C(=O)O)O4)c2)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| 14541297 | 201473 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 496 | 13 | 2 | 6 | 5.6 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)C3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| CHEMBL53347 | 201473 | 0 | None | - | 0 | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 496 | 13 | 2 | 6 | 5.6 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)C3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | ||
| 10392358 | 54647 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 534 | 12 | 1 | 6 | 6.6 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(SCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15491 | 54647 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 534 | 12 | 1 | 6 | 6.6 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(SCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | ||
| 44288319 | 175650 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 617 | 13 | 2 | 5 | 9.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(Cl)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL43821 | 175650 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 617 | 13 | 2 | 5 | 9.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(Cl)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 6193 | 10756 | 38 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | ||
| 6509849 | 10756 | 38 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | ||
| CHEMBL280481 | 10756 | 38 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | ||
| 15290701 | 212944 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 557 | 12 | 2 | 5 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sccc3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL86264 | 212944 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 557 | 12 | 2 | 5 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sccc3n2)c1 | 10.1016/0960-894X(95)00448-3 | ||
| 44269987 | 54580 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 528 | 13 | 1 | 5 | 6.6 | CC(CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| CHEMBL15485 | 54580 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 528 | 13 | 1 | 5 | 6.6 | CC(CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | ||
| 44319774 | 212776 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 635 | 11 | 1 | 4 | 10.5 | O=C(O)CC1(CS[C@H](CCc2ccc(C(F)(F)F)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| CHEMBL84841 | 212776 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 635 | 11 | 1 | 4 | 10.5 | O=C(O)CC1(CS[C@H](CCc2ccc(C(F)(F)F)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | ||
| 44350182 | 23357 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 500 | 12 | 1 | 6 | 5.9 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(SCc2ccc3ccccc3n2)c1 | 10.1021/jm00099a011 | ||
| CHEMBL123958 | 23357 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 500 | 12 | 1 | 6 | 5.9 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(SCc2ccc3ccccc3n2)c1 | 10.1021/jm00099a011 | ||
| 9822618 | 136512 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 406 | 9 | 2 | 4 | 5.0 | CCC(CC)(CC(=O)Nc1cccc(OCc2ccc3ccccc3n2)c1)C(=O)O | 10.1016/s0960-894x(98)00137-1 | ||
| CHEMBL367424 | 136512 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 406 | 9 | 2 | 4 | 5.0 | CCC(CC)(CC(=O)Nc1cccc(OCc2ccc3ccccc3n2)c1)C(=O)O | 10.1016/s0960-894x(98)00137-1 | ||
| 45271629 | 202331 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 523 | 10 | 1 | 4 | 7.0 | CN(CCC(=O)O)CCc1cn(Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 | 10.1016/j.bmcl.2009.05.094 | ||
| CHEMBL554691 | 202331 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 523 | 10 | 1 | 4 | 7.0 | CN(CCC(=O)O)CCc1cn(Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 | 10.1016/j.bmcl.2009.05.094 | ||
| 44288613 | 164616 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 613 | 14 | 2 | 6 | 8.9 | COc1ccc(-c2csc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)n2)cc1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL40836 | 164616 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 613 | 14 | 2 | 6 | 8.9 | COc1ccc(-c2csc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)n2)cc1 | 10.1016/0960-894X(95)00265-U | ||
| 44288319 | 175650 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 617 | 13 | 2 | 5 | 9.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(Cl)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| CHEMBL43821 | 175650 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 617 | 13 | 2 | 5 | 9.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(Cl)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | ||
| 10346 | 9337 | 46 | None | - | 1 | Guinea pig | 9.0 | pKd | = | 9 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00166a017 | ||
| 5281888 | 9337 | 46 | None | - | 1 | Guinea pig | 9.0 | pKd | = | 9 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00166a017 | ||
| CHEMBL15177 | 9337 | 46 | None | - | 1 | Guinea pig | 9.0 | pKd | = | 9 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00166a017 | ||
| 10839186 | 126485 | 0 | None | - | 1 | Guinea pig | 7.0 | pKd | = | 7 | Binding | ChEMBL | 502 | 5 | 1 | 6 | 5.4 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ncc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL34740 | 126485 | 0 | None | - | 1 | Guinea pig | 7.0 | pKd | = | 7 | Binding | ChEMBL | 502 | 5 | 1 | 6 | 5.4 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ncc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| 9890153 | 169297 | 0 | None | - | 1 | Guinea pig | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 453 | 4 | 1 | 4 | 6.5 | O=C(O)c1cc(Cl)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL416769 | 169297 | 0 | None | - | 1 | Guinea pig | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 453 | 4 | 1 | 4 | 6.5 | O=C(O)c1cc(Cl)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| 10764782 | 169518 | 0 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 424 | 5 | 1 | 6 | 4.7 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ncc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| CHEMBL417135 | 169518 | 0 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 424 | 5 | 1 | 6 | 4.7 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ncc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| 15485487 | 120437 | 0 | None | - | 1 | Guinea pig | 5.0 | pKd | = | 5.0 | Binding | ChEMBL | 477 | 4 | 1 | 6 | 6.0 | O=c1cc(-c2cccc(/C=C/c3ccc4ccccc4n3)c2)oc2c(-c3nn[nH]n3)cc(Cl)cc12 | 10.1021/jm970179x | ||
| CHEMBL33228 | 120437 | 0 | None | - | 1 | Guinea pig | 5.0 | pKd | = | 5.0 | Binding | ChEMBL | 477 | 4 | 1 | 6 | 6.0 | O=c1cc(-c2cccc(/C=C/c3ccc4ccccc4n3)c2)oc2c(-c3nn[nH]n3)cc(Cl)cc12 | 10.1021/jm970179x | ||
| 105007 | 103875 | 32 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00013a023 | ||
| CHEMBL267475 | 103875 | 32 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00013a023 | ||
| CHEMBL267976 | 103875 | 32 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00013a023 | ||
| 10649085 | 125521 | 0 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 500 | 5 | 1 | 4 | 6.7 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5c4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL34177 | 125521 | 0 | None | - | 1 | Guinea pig | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 500 | 5 | 1 | 4 | 6.7 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5c4)c3)oc12 | 10.1021/jm970179x | ||
| 10792471 | 123485 | 0 | None | - | 1 | Guinea pig | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 535 | 5 | 1 | 5 | 6.7 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccc(Cl)cc5n4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL33729 | 123485 | 0 | None | - | 1 | Guinea pig | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 535 | 5 | 1 | 5 | 6.7 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccc(Cl)cc5n4)c3)oc12 | 10.1021/jm970179x | ||
| 10717827 | 106488 | 0 | None | - | 1 | Guinea pig | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 437 | 4 | 1 | 4 | 6.0 | O=C(O)c1cc(F)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL284730 | 106488 | 0 | None | - | 1 | Guinea pig | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 437 | 4 | 1 | 4 | 6.0 | O=C(O)c1cc(F)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| 10765224 | 126588 | 0 | None | - | 1 | Guinea pig | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 433 | 4 | 1 | 4 | 6.2 | Cc1cc(C(=O)O)c2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1021/jm970179x | ||
| CHEMBL34835 | 126588 | 0 | None | - | 1 | Guinea pig | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 433 | 4 | 1 | 4 | 6.2 | Cc1cc(C(=O)O)c2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1021/jm970179x | ||
| 10526098 | 106475 | 1 | None | - | 1 | Guinea pig | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL284624 | 106475 | 1 | None | - | 1 | Guinea pig | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| 10767627 | 115883 | 0 | None | - | 1 | Guinea pig | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 497 | 4 | 1 | 4 | 6.6 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL32136 | 115883 | 0 | None | - | 1 | Guinea pig | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 497 | 4 | 1 | 4 | 6.6 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| 10574284 | 123751 | 0 | None | - | 1 | Guinea pig | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL33871 | 123751 | 0 | None | - | 1 | Guinea pig | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| 10764530 | 119131 | 0 | None | - | 1 | Guinea pig | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1ccc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc2c1 | 10.1021/jm970179x | ||
| CHEMBL32944 | 119131 | 0 | None | - | 1 | Guinea pig | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1ccc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc2c1 | 10.1021/jm970179x | ||
| 10787157 | 120885 | 0 | None | - | 1 | Guinea pig | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 400 | 3 | 0 | 4 | 6.1 | N#Cc1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1021/jm970179x | ||
| CHEMBL33276 | 120885 | 0 | None | - | 1 | Guinea pig | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 400 | 3 | 0 | 4 | 6.1 | N#Cc1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1021/jm970179x | ||
| 10577476 | 121217 | 0 | None | - | 1 | Guinea pig | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 504 | 5 | 1 | 6 | 5.4 | Cn1c(COc2cccc(-c3cc(=O)c4cc(Br)cc(C(=O)O)c4o3)c2)nc2ccccc21 | 10.1021/jm970179x | ||
| CHEMBL33331 | 121217 | 0 | None | - | 1 | Guinea pig | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 504 | 5 | 1 | 6 | 5.4 | Cn1c(COc2cccc(-c3cc(=O)c4cc(Br)cc(C(=O)O)c4o3)c2)nc2ccccc21 | 10.1021/jm970179x | ||
| 44461723 | 212734 | 0 | None | -398 | 2 | Guinea pig | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 519 | 8 | 0 | 8 | 7.0 | O=c1cc(C2N=NN=N2)oc2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc12 | 10.1021/jm00013a023 | ||
| CHEMBL84407 | 212734 | 0 | None | -398 | 2 | Guinea pig | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 519 | 8 | 0 | 8 | 7.0 | O=c1cc(C2N=NN=N2)oc2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc12 | 10.1021/jm00013a023 | ||
| 10502162 | 118248 | 0 | None | - | 1 | Guinea pig | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3ccc(/C=C/c4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| CHEMBL32764 | 118248 | 0 | None | - | 1 | Guinea pig | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3ccc(/C=C/c4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| 115219 | 8759 | 14 | None | -489 | 3 | Guinea pig | 4.5 | pKd | = | 4.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1016/S0960-894X(97)00219-9 | ||
| 3358 | 8759 | 14 | None | -489 | 3 | Guinea pig | 4.5 | pKd | = | 4.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1016/S0960-894X(97)00219-9 | ||
| 3414 | 8759 | 14 | None | -489 | 3 | Guinea pig | 4.5 | pKd | = | 4.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1016/S0960-894X(97)00219-9 | ||
| CHEMBL22033 | 8759 | 14 | None | -489 | 3 | Guinea pig | 4.5 | pKd | = | 4.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1016/S0960-894X(97)00219-9 | ||
| 15485486 | 123216 | 0 | None | - | 1 | Guinea pig | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 443 | 4 | 1 | 6 | 5.4 | O=c1cc(-c2cccc(/C=C/c3ccc4ccccc4n3)c2)oc2ccc(-c3nn[nH]n3)cc12 | 10.1021/jm970179x | ||
| CHEMBL33607 | 123216 | 0 | None | - | 1 | Guinea pig | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 443 | 4 | 1 | 6 | 5.4 | O=c1cc(-c2cccc(/C=C/c3ccc4ccccc4n3)c2)oc2ccc(-c3nn[nH]n3)cc12 | 10.1021/jm970179x | ||
| 10553494 | 115898 | 0 | None | - | 1 | Guinea pig | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL32138 | 115898 | 0 | None | - | 1 | Guinea pig | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | ||
| 10651746 | 106667 | 0 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 640 | 7 | 1 | 7 | 6.5 | O=C(NS(=O)(=O)c1ccccc1)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| CHEMBL285994 | 106667 | 0 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 640 | 7 | 1 | 7 | 6.5 | O=C(NS(=O)(=O)c1ccccc1)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| 10598159 | 121215 | 0 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1021/jm970179x | ||
| CHEMBL33329 | 121215 | 0 | None | - | 1 | Guinea pig | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1021/jm970179x | ||
| 10435880 | 212139 | 0 | None | -707 | 2 | Guinea pig | 5.4 | pKd | = | 5.4 | Binding | ChEMBL | 495 | 8 | 1 | 5 | 5.9 | O=C(O)c1cc(=O)c2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc2o1 | 10.1021/jm00013a023 | ||
| CHEMBL79732 | 212139 | 0 | None | -707 | 2 | Guinea pig | 5.4 | pKd | = | 5.4 | Binding | ChEMBL | 495 | 8 | 1 | 5 | 5.9 | O=C(O)c1cc(=O)c2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc2o1 | 10.1021/jm00013a023 | ||
| 10649109 | 126229 | 0 | None | - | 1 | Guinea pig | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| CHEMBL34507 | 126229 | 0 | None | - | 1 | Guinea pig | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| 11796528 | 120930 | 0 | None | - | 1 | Guinea pig | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| CHEMBL33294 | 120930 | 0 | None | - | 1 | Guinea pig | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | ||
| 10619270 | 106788 | 0 | None | - | 1 | Guinea pig | 4.3 | pKd | = | 4.3 | Binding | ChEMBL | 372 | 5 | 1 | 4 | 4.7 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ccccc4)cc3)oc12 | 10.1021/jm970179x | ||
| CHEMBL286797 | 106788 | 0 | None | - | 1 | Guinea pig | 4.3 | pKd | = | 4.3 | Binding | ChEMBL | 372 | 5 | 1 | 4 | 4.7 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ccccc4)cc3)oc12 | 10.1021/jm970179x | ||
| 10553667 | 106891 | 0 | None | - | 1 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 507 | 5 | 1 | 6 | 6.1 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4nc5ccccc5s4)c3)oc12 | 10.1021/jm970179x | ||
| CHEMBL287559 | 106891 | 0 | None | - | 1 | Guinea pig | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 507 | 5 | 1 | 6 | 6.1 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4nc5ccccc5s4)c3)oc12 | 10.1021/jm970179x | ||
| 15675874 | 186421 | 0 | None | - | 1 | Guinea pig | 10.0 | pKi | = | 10 | Binding | ChEMBL | 479 | 7 | 1 | 8 | 4.6 | O=C1CC(c2nnn[nH]2)Oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| CHEMBL47430 | 186421 | 0 | None | - | 1 | Guinea pig | 10.0 | pKi | = | 10 | Binding | ChEMBL | 479 | 7 | 1 | 8 | 4.6 | O=C1CC(c2nnn[nH]2)Oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| 15675885 | 185280 | 0 | None | - | 1 | Guinea pig | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 479 | 7 | 1 | 8 | 4.6 | O=C1CC(c2nnn[nH]2)Oc2cc(COc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| CHEMBL46663 | 185280 | 0 | None | - | 1 | Guinea pig | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 479 | 7 | 1 | 8 | 4.6 | O=C1CC(c2nnn[nH]2)Oc2cc(COc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| 10346 | 9337 | 46 | None | - | 1 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00108a001 | ||
| 5281888 | 9337 | 46 | None | - | 1 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00108a001 | ||
| CHEMBL15177 | 9337 | 46 | None | - | 1 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00108a001 | ||
| 5280878 | 107049 | 27 | None | 2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/j.bmcl.2013.01.025 | ||
| CHEMBL288943 | 107049 | 27 | None | 2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/j.bmcl.2013.01.025 | ||
| 115219 | 8759 | 14 | None | -489 | 3 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00109a025 | ||
| 3358 | 8759 | 14 | None | -489 | 3 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00109a025 | ||
| 3414 | 8759 | 14 | None | -489 | 3 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00109a025 | ||
| CHEMBL22033 | 8759 | 14 | None | -489 | 3 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00109a025 | ||
| 15675873 | 178944 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 477 | 7 | 1 | 7 | 4.8 | O=C1CC(c2nnn[nH]2)Oc2cc(CCc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| CHEMBL44734 | 178944 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 477 | 7 | 1 | 7 | 4.8 | O=C1CC(c2nnn[nH]2)Oc2cc(CCc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| 2855 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm970180w | ||
| 3322 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm970180w | ||
| 5717 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm970180w | ||
| CHEMBL603 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm970180w | ||
| DB00549 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm970180w | ||
| 2855 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00108a001 | ||
| 3322 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00108a001 | ||
| 5717 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00108a001 | ||
| CHEMBL603 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00108a001 | ||
| DB00549 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00108a001 | ||
| 115219 | 8759 | 14 | None | -489 | 3 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00108a001 | ||
| 3358 | 8759 | 14 | None | -489 | 3 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00108a001 | ||
| 3414 | 8759 | 14 | None | -489 | 3 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00108a001 | ||
| CHEMBL22033 | 8759 | 14 | None | -489 | 3 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00108a001 | ||
| 2855 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| 3322 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| 5717 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| CHEMBL603 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| DB00549 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | ||
| 2855 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00168a037 | ||
| 3322 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00168a037 | ||
| 5717 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00168a037 | ||
| CHEMBL603 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00168a037 | ||
| DB00549 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00168a037 | ||
| 14626819 | 195445 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 559 | 9 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL50370 | 195445 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 559 | 9 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 10461224 | 123869 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 601 | 11 | 2 | 6 | 6.0 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC3CCCC3)ccc21 | 10.1021/jm00055a011 | ||
| CHEMBL339277 | 123869 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 601 | 11 | 2 | 6 | 6.0 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC3CCCC3)ccc21 | 10.1021/jm00055a011 | ||
| 2855 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00035a008 | ||
| 3322 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00035a008 | ||
| 5717 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00035a008 | ||
| CHEMBL603 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00035a008 | ||
| DB00549 | 10904 | 104 | None | -1 | 6 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00035a008 | ||
| 10349048 | 103722 | 0 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 629 | 11 | 2 | 6 | 6.0 | CCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(C)CC(F)(F)F)ccc21 | 10.1021/jm00035a008 | ||
| CHEMBL26617 | 103722 | 0 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 629 | 11 | 2 | 6 | 6.0 | CCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(C)CC(F)(F)F)ccc21 | 10.1021/jm00035a008 | ||
| 10077296 | 26933 | 0 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 599 | 11 | 2 | 6 | 5.8 | C=CCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC3CCCC3)ccc21 | 10.1021/jm00055a011 | ||
| CHEMBL130463 | 26933 | 0 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 599 | 11 | 2 | 6 | 5.8 | C=CCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC3CCCC3)ccc21 | 10.1021/jm00055a011 | ||
| 9895247 | 214586 | 2 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 616 | 8 | 2 | 8 | 5.7 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@@H]1COc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@@H]1O | 10.1016/s0960-894x(99)00461-8 | ||
| CHEMBL96224 | 214586 | 2 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 616 | 8 | 2 | 8 | 5.7 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@@H]1COc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@@H]1O | 10.1016/s0960-894x(99)00461-8 | ||
| 204056 | 176178 | 31 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC[C@H](C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL442263 | 176178 | 31 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC[C@H](C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 10054552 | 100217 | 0 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.8 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cn1cc(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | ||
| CHEMBL24596 | 100217 | 0 | None | - | 1 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.8 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cn1cc(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | ||
| 1836 | 9370 | 59 | None | 1 | 15 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm970180w | ||
| 3340 | 9370 | 59 | None | 1 | 15 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm970180w | ||
| 5281040 | 9370 | 59 | None | 1 | 15 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm970180w | ||
| CHEMBL787 | 9370 | 59 | None | 1 | 15 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm970180w | ||
| DB00471 | 9370 | 59 | None | 1 | 15 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm970180w | ||
| 14626858 | 197963 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL51891 | 197963 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 14626821 | 200136 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 588 | 10 | 3 | 6 | 5.8 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2OC)c2cc(NC(=O)NC3CCCC3)ccc21 | 10.1021/jm00168a037 | ||
| CHEMBL52492 | 200136 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 588 | 10 | 3 | 6 | 5.8 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2OC)c2cc(NC(=O)NC3CCCC3)ccc21 | 10.1021/jm00168a037 | ||
| 10371436 | 123857 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 603 | 12 | 2 | 6 | 6.4 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C(C)C | 10.1021/jm00055a011 | ||
| CHEMBL339242 | 123857 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 603 | 12 | 2 | 6 | 6.4 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C(C)C | 10.1021/jm00055a011 | ||
| 14626858 | 197963 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00055a011 | ||
| CHEMBL51891 | 197963 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00055a011 | ||
| 9986282 | 100356 | 11 | None | - | 1 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL24652 | 100356 | 11 | None | - | 1 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 10258533 | 102597 | 0 | None | - | 1 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 635 | 10 | 2 | 6 | 5.9 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL25885 | 102597 | 0 | None | - | 1 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 635 | 10 | 2 | 6 | 5.9 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 5280878 | 107049 | 27 | None | 2 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1021/np50094a001 | ||
| CHEMBL288943 | 107049 | 27 | None | 2 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1021/np50094a001 | ||
| 9830317 | 214582 | 9 | None | - | 1 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 608 | 8 | 2 | 7 | 6.0 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@@H]1COc2ccc(OCc3ccc4ccc(Cl)cc4n3)cc2[C@@H]1O | 10.1016/s0960-894x(99)00461-8 | ||
| CHEMBL96206 | 214582 | 9 | None | - | 1 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 608 | 8 | 2 | 7 | 6.0 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@@H]1COc2ccc(OCc3ccc4ccc(Cl)cc4n3)cc2[C@@H]1O | 10.1016/s0960-894x(99)00461-8 | ||
| 10483776 | 121597 | 0 | None | - | 1 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc21 | 10.1021/jm00055a011 | ||
| CHEMBL334122 | 121597 | 0 | None | - | 1 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc21 | 10.1021/jm00055a011 | ||
| 14626814 | 191118 | 0 | None | -10 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 561 | 8 | 2 | 7 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.6b01287 | ||
| CHEMBL48435 | 191118 | 0 | None | -10 | 2 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 561 | 8 | 2 | 7 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.6b01287 | ||
| 14626820 | 108760 | 0 | None | - | 1 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 560 | 8 | 3 | 6 | 5.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL301498 | 108760 | 0 | None | - | 1 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 560 | 8 | 3 | 6 | 5.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 2237 | 9936 | 79 | None | 4 | 3 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(99)00461-8 | ||
| 3634 | 9936 | 79 | None | 4 | 3 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(99)00461-8 | ||
| 4887 | 9936 | 79 | None | 4 | 3 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(99)00461-8 | ||
| CHEMBL21333 | 9936 | 79 | None | 4 | 3 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(99)00461-8 | ||
| DB01411 | 9936 | 79 | None | 4 | 3 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(99)00461-8 | ||
| 2855 | 10904 | 104 | None | 1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| 3322 | 10904 | 104 | None | 1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| 5717 | 10904 | 104 | None | 1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| CHEMBL603 | 10904 | 104 | None | 1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| DB00549 | 10904 | 104 | None | 1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | ||
| 10394412 | 30779 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 643 | 13 | 2 | 6 | 7.0 | CCC(CC)CNC(=O)c1ccc2c(CC3CCCC3)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| CHEMBL133790 | 30779 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 643 | 13 | 2 | 6 | 7.0 | CCC(CC)CNC(=O)c1ccc2c(CC3CCCC3)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| 10326077 | 27908 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 589 | 12 | 2 | 6 | 5.9 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2CC | 10.1021/jm00055a011 | ||
| CHEMBL131247 | 27908 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 589 | 12 | 2 | 6 | 5.9 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2CC | 10.1021/jm00055a011 | ||
| 5280878 | 107049 | 27 | None | -2 | 2 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL288943 | 107049 | 27 | None | -2 | 2 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| 14626857 | 108675 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 559 | 9 | 3 | 5 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1c[nH]c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL300846 | 108675 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 559 | 9 | 3 | 5 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1c[nH]c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 9891157 | 28831 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 476 | 8 | 2 | 4 | 5.6 | O=C(O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL132162 | 28831 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 476 | 8 | 2 | 4 | 5.6 | O=C(O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 15675887 | 188332 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 492 | 6 | 2 | 8 | 4.3 | O=C(Nc1cccc2c1OC(c1nnn[nH]1)CC2=O)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00109a025 | ||
| CHEMBL47662 | 188332 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 492 | 6 | 2 | 8 | 4.3 | O=C(Nc1cccc2c1OC(c1nnn[nH]1)CC2=O)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00109a025 | ||
| 14842376 | 106537 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 490 | 6 | 2 | 8 | 4.4 | O=C(Nc1cccc2c(=O)cc(-c3nn[nH]n3)oc12)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm970180w | ||
| CHEMBL285070 | 106537 | 0 | None | - | 1 | Guinea pig | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 490 | 6 | 2 | 8 | 4.4 | O=C(Nc1cccc2c(=O)cc(-c3nn[nH]n3)oc12)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm970180w | ||
| 1836 | 9370 | 59 | None | -1 | 15 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| 3340 | 9370 | 59 | None | -1 | 15 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| 5281040 | 9370 | 59 | None | -1 | 15 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| CHEMBL787 | 9370 | 59 | None | -1 | 15 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| DB00471 | 9370 | 59 | None | -1 | 15 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | ||
| 9935613 | 108016 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 497 | 9 | 1 | 6 | 6.0 | CC1(CCC(=O)O)CC(=O)c2ccc(OCc3cccc(OCc4ccc5ccccc5n4)c3)cc2O1 | 10.1021/jm00109a025 | ||
| CHEMBL296097 | 108016 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 497 | 9 | 1 | 6 | 6.0 | CC1(CCC(=O)O)CC(=O)c2ccc(OCc3cccc(OCc4ccc5ccccc5n4)c3)cc2O1 | 10.1021/jm00109a025 | ||
| 10417026 | 100062 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 669 | 10 | 2 | 6 | 6.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCC(C(F)(F)F)C(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL24505 | 100062 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 669 | 10 | 2 | 6 | 6.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCC(C(F)(F)F)C(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 10348645 | 27445 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| CHEMBL130872 | 27445 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| 9986751 | 123048 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 651 | 13 | 2 | 6 | 6.9 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2Cc1ccccc1 | 10.1021/jm00055a011 | ||
| CHEMBL335889 | 123048 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 651 | 13 | 2 | 6 | 6.9 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2Cc1ccccc1 | 10.1021/jm00055a011 | ||
| 15675876 | 183941 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2ccc(OCc3cccc(OCc4ccc5ccccc5n4)c3)cc21 | 10.1021/jm00109a025 | ||
| CHEMBL46343 | 183941 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2ccc(OCc3cccc(OCc4ccc5ccccc5n4)c3)cc21 | 10.1021/jm00109a025 | ||
| 10009390 | 102984 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 645 | 9 | 2 | 6 | 5.6 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3CC(F)(F)C(F)(F)C3)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL26080 | 102984 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 645 | 9 | 2 | 6 | 5.6 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3CC(F)(F)C(F)(F)C3)cc12 | 10.1021/jm00035a008 | ||
| 14626863 | 174690 | 1 | None | -1 | 2 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 574 | 8 | 3 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL431348 | 174690 | 1 | None | -1 | 2 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 574 | 8 | 3 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 9986283 | 100582 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC[C@@H](C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL24758 | 100582 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC[C@@H](C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 44352406 | 28286 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL131611 | 28286 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 10394407 | 102469 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 643 | 12 | 2 | 6 | 6.4 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(C)CC(F)(F)F)ccc21 | 10.1021/jm00035a008 | ||
| CHEMBL25819 | 102469 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 643 | 12 | 2 | 6 | 6.4 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(C)CC(F)(F)F)ccc21 | 10.1021/jm00035a008 | ||
| 9985579 | 105912 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.4 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| CHEMBL281066 | 105912 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.4 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| 10348137 | 26902 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.5 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(C)C)ccc21 | 10.1021/jm00055a011 | ||
| CHEMBL130428 | 26902 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.5 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(C)C)ccc21 | 10.1021/jm00055a011 | ||
| 44285405 | 161169 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](Sc1cccc(C(=O)O)c1)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL39876 | 161169 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](Sc1cccc(C(=O)O)c1)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| 44285360 | 175066 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 410 | 17 | 3 | 4 | 5.0 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL434013 | 175066 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 410 | 17 | 3 | 4 | 5.0 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| 44272172 | 73577 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(OCc2cccc(OCc3ccc4ccccc4n3)c2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18600 | 73577 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(OCc2cccc(OCc3ccc4ccccc4n3)c2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| 9888538 | 73732 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc(Cc2nnn[nH]2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18671 | 73732 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc(Cc2nnn[nH]2)c1 | 10.1021/jm00166a017 | ||
| 10158419 | 169943 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(OCc2ccc(-c3nn[nH]n3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL418002 | 169943 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(OCc2ccc(-c3nn[nH]n3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 3334 | 9921 | 9 | None | -5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00389a001 | ||
| 60842 | 9921 | 9 | None | -5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00389a001 | ||
| CHEMBL22776 | 9921 | 9 | None | -5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00389a001 | ||
| 10461264 | 28197 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCCCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| CHEMBL131507 | 28197 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCCCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| 10076815 | 212455 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cn1cc(C)c2ccc(C(=O)NCC3CCCC3)cc21 | 10.1021/jm00055a011 | ||
| CHEMBL82190 | 212455 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cn1cc(C)c2ccc(C(=O)NCC3CCCC3)cc21 | 10.1021/jm00055a011 | ||
| 15337931 | 212590 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 496 | 8 | 1 | 6 | 5.3 | Clc1ccc2ccc(COc3cccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)c3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| CHEMBL83267 | 212590 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8 | Binding | ChEMBL | 496 | 8 | 1 | 6 | 5.3 | Clc1ccc2ccc(COc3cccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)c3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| 10348087 | 27582 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 573 | 8 | 2 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC3CCCCC3)cc12 | 10.1021/jm00055a011 | ||
| CHEMBL130985 | 27582 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 573 | 8 | 2 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC3CCCCC3)cc12 | 10.1021/jm00055a011 | ||
| 44353486 | 123516 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 601 | 9 | 1 | 6 | 5.9 | CCCC1CCN(C(=O)c2ccc3c(c2)c(Cc2ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc2OC)cn3C)CC1 | 10.1021/jm00055a011 | ||
| CHEMBL337473 | 123516 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 601 | 9 | 1 | 6 | 5.9 | CCCC1CCN(C(=O)c2ccc3c(c2)c(Cc2ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc2OC)cn3C)CC1 | 10.1021/jm00055a011 | ||
| 3381 | 7376 | 27 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| 5311015 | 7376 | 27 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL285954 | 7376 | 27 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7 | Binding | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| 14406203 | 201250 | 0 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 322 | 5 | 1 | 4 | 3.2 | CN(O)C(=O)Cc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00128a027 | ||
| CHEMBL52896 | 201250 | 0 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 322 | 5 | 1 | 4 | 3.2 | CN(O)C(=O)Cc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00128a027 | ||
| 13770359 | 76069 | 2 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 235 | 3 | 0 | 2 | 3.8 | c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a016 | ||
| CHEMBL19281 | 76069 | 2 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 235 | 3 | 0 | 2 | 3.8 | c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a016 | ||
| 10047878 | 124241 | 0 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 422 | 9 | 2 | 4 | 4.9 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)O)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| CHEMBL339897 | 124241 | 0 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 422 | 9 | 2 | 4 | 4.9 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)O)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| 10475982 | 168603 | 0 | None | 15 | 2 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | ||
| CHEMBL414462 | 168603 | 0 | None | 15 | 2 | Guinea pig | 6.0 | pKi | = | 6 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | ||
| 129232 | 201739 | 32 | None | - | 1 | Guinea pig | 4.0 | pKi | = | 4 | Binding | ChEMBL | 271 | 5 | 1 | 3 | 2.7 | CN(O)C(=O)Cc1ccc(OCc2ccccc2)cc1 | 10.1021/jm00128a027 | ||
| CHEMBL54453 | 201739 | 32 | None | - | 1 | Guinea pig | 4.0 | pKi | = | 4 | Binding | ChEMBL | 271 | 5 | 1 | 3 | 2.7 | CN(O)C(=O)Cc1ccc(OCc2ccccc2)cc1 | 10.1021/jm00128a027 | ||
| 44352444 | 25725 | 0 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 503 | 8 | 2 | 7 | 4.3 | Cn1cc(CC(=O)NCc2ccc(-c3nn[nH]n3)cc2)c2cc(OCc3ccc4ccccc4n3)ccc21 | 10.1021/jm990387k | ||
| CHEMBL128676 | 25725 | 0 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 503 | 8 | 2 | 7 | 4.3 | Cn1cc(CC(=O)NCc2ccc(-c3nn[nH]n3)cc2)c2cc(OCc3ccc4ccccc4n3)ccc21 | 10.1021/jm990387k | ||
| 44352153 | 27940 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 450 | 8 | 2 | 6 | 4.1 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)Nc1ccc(Cc2nnn[nH]2)cc1 | 10.1021/jm990387k | ||
| CHEMBL131266 | 27940 | 0 | None | - | 1 | Guinea pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 450 | 8 | 2 | 6 | 4.1 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)Nc1ccc(Cc2nnn[nH]2)cc1 | 10.1021/jm990387k | ||
| 14742716 | 214793 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 401 | 10 | 1 | 5 | 4.9 | CCCC(CCc1nnn[nH]1)Cc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00172a024 | ||
| CHEMBL97356 | 214793 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 401 | 10 | 1 | 5 | 4.9 | CCCC(CCc1nnn[nH]1)Cc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00172a024 | ||
| 14626843 | 108403 | 0 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 421 | 6 | 3 | 4 | 4.5 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL298939 | 108403 | 0 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 421 | 6 | 3 | 4 | 4.5 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 9948371 | 74141 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 303 | 4 | 1 | 5 | 3.0 | c1cc(OCc2ccc3ccccc3n2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL18864 | 74141 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 303 | 4 | 1 | 5 | 3.0 | c1cc(OCc2ccc3ccccc3n2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a016 | ||
| 44352451 | 26914 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 6.4 | CC(C(=O)Nc1ccc(C(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL130442 | 26914 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 6.4 | CC(C(=O)Nc1ccc(C(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 9888539 | 71617 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2ccccc2Cc2nnn[nH]2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18204 | 71617 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2ccccc2Cc2nnn[nH]2)c1 | 10.1021/jm00166a017 | ||
| 44352414 | 25687 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1ccccc1-c1nn[nH]n1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL128483 | 25687 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1ccccc1-c1nn[nH]n1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 10461218 | 106856 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)C(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL287302 | 106856 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 601 | 9 | 2 | 6 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)C(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 9985297 | 123439 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 561 | 11 | 2 | 6 | 5.3 | CCC(CC)CNC(=O)c1ccc2ccn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| CHEMBL337058 | 123439 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 561 | 11 | 2 | 6 | 5.3 | CCC(CC)CNC(=O)c1ccc2ccn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| 14650365 | 72021 | 1 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 375 | 9 | 1 | 6 | 3.5 | c1ccc2nc(COCc3ccc(OCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| CHEMBL18273 | 72021 | 1 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 375 | 9 | 1 | 6 | 3.5 | c1ccc2nc(COCc3ccc(OCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| 14650341 | 105428 | 0 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 337 | 8 | 1 | 4 | 4.1 | O=C(O)CCCOc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a016 | ||
| CHEMBL277292 | 105428 | 0 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 337 | 8 | 1 | 4 | 4.1 | O=C(O)CCCOc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a016 | ||
| 105007 | 103875 | 32 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00389a001 | ||
| CHEMBL267475 | 103875 | 32 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00389a001 | ||
| CHEMBL267976 | 103875 | 32 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00389a001 | ||
| 11758126 | 123366 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 589 | 12 | 2 | 6 | 5.9 | CCCCC(CC)NC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| CHEMBL336607 | 123366 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 589 | 12 | 2 | 6 | 5.9 | CCCCC(CC)NC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| 44285543 | 153615 | 0 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 540 | 21 | 3 | 4 | 8.2 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL39250 | 153615 | 0 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 540 | 21 | 3 | 4 | 8.2 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| 10203560 | 169608 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(OCc2cccc(OCc3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL417271 | 169608 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(OCc2cccc(OCc3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 15675883 | 183243 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2c(COc3ccc(OCc4ccc5ccccc5n4)cc3)cccc21 | 10.1021/jm00109a025 | ||
| CHEMBL45965 | 183243 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2c(COc3ccc(OCc4ccc5ccccc5n4)cc3)cccc21 | 10.1021/jm00109a025 | ||
| 23224640 | 26843 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 514 | 9 | 2 | 6 | 5.5 | O=C(NCCCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| CHEMBL130384 | 26843 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 514 | 9 | 2 | 6 | 5.5 | O=C(NCCCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| 44352282 | 125231 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 526 | 9 | 1 | 5 | 5.5 | CN(CCc1ccc(C(=O)O)cc1)S(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| CHEMBL341172 | 125231 | 0 | None | - | 1 | Guinea pig | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 526 | 9 | 1 | 5 | 5.5 | CN(CCc1ccc(C(=O)O)cc1)S(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| 9927762 | 73051 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 337 | 8 | 1 | 4 | 4.1 | O=C(O)CCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL18471 | 73051 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 337 | 8 | 1 | 4 | 4.1 | O=C(O)CCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| 10363485 | 65877 | 0 | None | 29 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | ||
| CHEMBL169743 | 65877 | 0 | None | 29 | 2 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | ||
| 44352421 | 28571 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 504 | 9 | 2 | 4 | 6.0 | CC(C(=O)NCc1ccc(CC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL131934 | 28571 | 0 | None | - | 1 | Guinea pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 504 | 9 | 2 | 4 | 6.0 | CC(C(=O)NCc1ccc(CC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 5352624 | 74013 | 44 | None | -4 | 5 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 340 | 4 | 1 | 2 | 5.4 | CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1 | nan | ||
| CHEMBL18797 | 74013 | 44 | None | -4 | 5 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 340 | 4 | 1 | 2 | 5.4 | CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1 | nan | ||
| 15675884 | 194721 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 479 | 7 | 1 | 8 | 4.6 | O=C1CC(c2nnn[nH]2)Oc2c(COc3ccc(OCc4ccc5ccccc5n4)cc3)cccc21 | 10.1021/jm00109a025 | ||
| CHEMBL49696 | 194721 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 479 | 7 | 1 | 8 | 4.6 | O=C1CC(c2nnn[nH]2)Oc2c(COc3ccc(OCc4ccc5ccccc5n4)cc3)cccc21 | 10.1021/jm00109a025 | ||
| 44352162 | 25393 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 629 | 10 | 2 | 6 | 6.4 | Cc1ccccc1S(=O)(=O)NC(=O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL127665 | 25393 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 629 | 10 | 2 | 6 | 6.4 | Cc1ccccc1S(=O)(=O)NC(=O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 44352411 | 175222 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 487 | 7 | 1 | 6 | 6.3 | O=C(O)c1ccc(Cc2noc(-c3ccc4ccc(OCc5ccc6ccccc6n5)cc4c3)n2)cc1 | 10.1021/jm990387k | ||
| CHEMBL434992 | 175222 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 487 | 7 | 1 | 6 | 6.3 | O=C(O)c1ccc(Cc2noc(-c3ccc4ccc(OCc5ccc6ccccc6n5)cc4c3)n2)cc1 | 10.1021/jm990387k | ||
| 10347819 | 29304 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 561 | 8 | 2 | 6 | 5.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)(C)C)cc12 | 10.1021/jm00055a011 | ||
| CHEMBL132582 | 29304 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 561 | 8 | 2 | 6 | 5.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)(C)C)cc12 | 10.1021/jm00055a011 | ||
| 10415427 | 172365 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 561 | 10 | 2 | 6 | 5.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCC(C)C)cc12 | 10.1021/jm00055a011 | ||
| CHEMBL424257 | 172365 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 561 | 10 | 2 | 6 | 5.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCC(C)C)cc12 | 10.1021/jm00055a011 | ||
| 15337934 | 113915 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 462 | 8 | 1 | 6 | 4.7 | c1cc(CCc2nnn[nH]2)c2c(c1)CCN2Cc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1016/0960-894X(96)00013-3 | ||
| CHEMBL316155 | 113915 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 462 | 8 | 1 | 6 | 4.7 | c1cc(CCc2nnn[nH]2)c2c(c1)CCN2Cc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1016/0960-894X(96)00013-3 | ||
| 19959108 | 212706 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 5.3 | C(=C/c1ccc2ccccc2n1)\c1cccc(CN2CCc3cccc(CCc4nnn[nH]4)c32)c1 | 10.1016/0960-894X(96)00013-3 | ||
| CHEMBL84150 | 212706 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 5.3 | C(=C/c1ccc2ccccc2n1)\c1cccc(CN2CCc3cccc(CCc4nnn[nH]4)c32)c1 | 10.1016/0960-894X(96)00013-3 | ||
| 5059 | 213140 | 44 | None | - | 1 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL8747 | 213140 | 44 | None | - | 1 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| 44277861 | 106310 | 0 | None | - | 1 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 395 | 5 | 1 | 3 | 5.7 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2CC[C@H]1Cc1ccccc1 | 10.1016/0960-894X(95)00225-I | ||
| CHEMBL283455 | 106310 | 0 | None | - | 1 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 395 | 5 | 1 | 3 | 5.7 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2CC[C@H]1Cc1ccccc1 | 10.1016/0960-894X(95)00225-I | ||
| 44278542 | 112780 | 0 | None | - | 1 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 440 | 5 | 1 | 5 | 4.4 | Cc1nc(COc2ccc3c(c2)[C@@H](O)[C@@H](Cc2cccnc2)CO3)ccc1Br | 10.1016/0960-894X(95)00226-J | ||
| CHEMBL31325 | 112780 | 0 | None | - | 1 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 440 | 5 | 1 | 5 | 4.4 | Cc1nc(COc2ccc3c(c2)[C@@H](O)[C@@H](Cc2cccnc2)CO3)ccc1Br | 10.1016/0960-894X(95)00226-J | ||
| 11293119 | 108376 | 42 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 422 | 6 | 2 | 5 | 5.0 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.6b01287 | ||
| CHEMBL298727 | 108376 | 42 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 422 | 6 | 2 | 5 | 5.0 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.6b01287 | ||
| 11293119 | 108376 | 42 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 422 | 6 | 2 | 5 | 5.0 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL298727 | 108376 | 42 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 422 | 6 | 2 | 5 | 5.0 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 10158417 | 73494 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(OCc2cccc(-c3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18564 | 73494 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(OCc2cccc(-c3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 15015299 | 105499 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(-c2nn[nH]n2)ccc1OCc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL277831 | 105499 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(-c2nn[nH]n2)ccc1OCc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 14750536 | 71403 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 331 | 6 | 1 | 5 | 3.1 | c1ccc2nc(COc3ccc(CCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| CHEMBL18177 | 71403 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 331 | 6 | 1 | 5 | 3.1 | c1ccc2nc(COc3ccc(CCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| 9820486 | 73795 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 365 | 9 | 0 | 5 | 4.5 | CCOC(=O)CCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL18703 | 73795 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 365 | 9 | 0 | 5 | 4.5 | CCOC(=O)CCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| 14626829 | 107909 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 423 | 6 | 2 | 6 | 4.4 | COc1cc(C(=O)O)ccc1Cc1nn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL295268 | 107909 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 423 | 6 | 2 | 6 | 4.4 | COc1cc(C(=O)O)ccc1Cc1nn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 14708733 | 108688 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 408 | 6 | 2 | 5 | 4.9 | COc1cc(C(=O)O)ccc1Cn1ccc2ccc(NC(=O)OC3CCCC3)cc21 | 10.1021/jm00168a037 | ||
| CHEMBL300940 | 108688 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 408 | 6 | 2 | 5 | 4.9 | COc1cc(C(=O)O)ccc1Cn1ccc2ccc(NC(=O)OC3CCCC3)cc21 | 10.1021/jm00168a037 | ||
| 9800998 | 106144 | 2 | None | 32 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | ||
| CHEMBL282524 | 106144 | 2 | None | 32 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | ||
| 9800998 | 106144 | 2 | None | 32 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00226-J | ||
| CHEMBL282524 | 106144 | 2 | None | 32 | 2 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00226-J | ||
| 2812 | 11551 | 101 | None | -58 | 34 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
| CHEMBL104 | 11551 | 101 | None | -58 | 34 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | ||
| 44352498 | 25180 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 466 | 6 | 2 | 6 | 4.9 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm990387k | ||
| CHEMBL127162 | 25180 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 466 | 6 | 2 | 6 | 4.9 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm990387k | ||
| 14774152 | 74440 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2ccccc2OCc2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL19072 | 74440 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2ccccc2OCc2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| 10294833 | 105740 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 407 | 7 | 1 | 5 | 4.8 | c1cc(CCc2cccc(-c3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL279770 | 105740 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 407 | 7 | 1 | 5 | 4.8 | c1cc(CCc2cccc(-c3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 14650383 | 162620 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 375 | 8 | 1 | 6 | 3.6 | Cc1cc(OCc2ccc3ccccc3n2)ccc1OCCCc1nnn[nH]1 | 10.1021/jm00166a016 | ||
| CHEMBL406006 | 162620 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 375 | 8 | 1 | 6 | 3.6 | Cc1cc(OCc2ccc3ccccc3n2)ccc1OCCCc1nnn[nH]1 | 10.1021/jm00166a016 | ||
| 14650346 | 214827 | 1 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 359 | 8 | 1 | 5 | 3.9 | c1ccc2nc(COc3ccc(CCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| CHEMBL97541 | 214827 | 1 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 359 | 8 | 1 | 5 | 3.9 | c1ccc2nc(COc3ccc(CCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| 44292186 | 107963 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 489 | 7 | 1 | 6 | 5.5 | O=C1CC(C(=O)O)Oc2ccc(Cl)c(OCc3ccc(OCc4ccc5ccccc5n4)cc3)c21 | 10.1021/jm00109a025 | ||
| CHEMBL295664 | 107963 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 489 | 7 | 1 | 6 | 5.5 | O=C1CC(C(=O)O)Oc2ccc(Cl)c(OCc3ccc(OCc4ccc5ccccc5n4)cc3)c21 | 10.1021/jm00109a025 | ||
| 10456871 | 66732 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | O=C(O)CCS[C@@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](O)C(=O)O | 10.1021/jm00389a001 | ||
| CHEMBL173289 | 66732 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | O=C(O)CCS[C@@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](O)C(=O)O | 10.1021/jm00389a001 | ||
| 14626841 | 201283 | 0 | None | - | 1 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 422 | 9 | 2 | 4 | 5.2 | CCCC(CC)C(=O)Nc1ccc2c(c1)c(Cc1ccc(C(=O)O)cc1OC)cn2C | 10.1021/jm00168a037 | ||
| CHEMBL52906 | 201283 | 0 | None | - | 1 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 422 | 9 | 2 | 4 | 5.2 | CCCC(CC)C(=O)Nc1ccc2c(c1)c(Cc1ccc(C(=O)O)cc1OC)cn2C | 10.1021/jm00168a037 | ||
| 44352235 | 25732 | 0 | None | - | 1 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 552 | 10 | 2 | 4 | 7.8 | CC(C(=O)Nc1ccc(CCCC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccc(Cl)cc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL128697 | 25732 | 0 | None | - | 1 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 552 | 10 | 2 | 4 | 7.8 | CC(C(=O)Nc1ccc(CCCC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccc(Cl)cc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 14626837 | 108365 | 0 | None | - | 1 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 408 | 9 | 2 | 4 | 5.0 | CCCCCC(=O)Nc1ccc2c(c1)c(Cc1ccc(C(=O)O)cc1OC)cn2C | 10.1021/jm00168a037 | ||
| CHEMBL298642 | 108365 | 0 | None | - | 1 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 408 | 9 | 2 | 4 | 5.0 | CCCCCC(=O)Nc1ccc2c(c1)c(Cc1ccc(C(=O)O)cc1OC)cn2C | 10.1021/jm00168a037 | ||
| 44285006 | 157811 | 0 | None | - | 1 | Guinea pig | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 456 | 15 | 3 | 4 | 5.8 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL39586 | 157811 | 0 | None | - | 1 | Guinea pig | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 456 | 15 | 3 | 4 | 5.8 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| 2855 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(99)00461-8 | ||
| 3322 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(99)00461-8 | ||
| 5717 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(99)00461-8 | ||
| CHEMBL603 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(99)00461-8 | ||
| DB00549 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(99)00461-8 | ||
| 15015283 | 73790 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1ccc(OCc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18699 | 73790 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1ccc(OCc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00166a017 | ||
| 15675878 | 194324 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| CHEMBL49449 | 194324 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| 1836 | 9370 | 59 | None | 1 | 15 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm990387k | ||
| 3340 | 9370 | 59 | None | 1 | 15 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm990387k | ||
| 5281040 | 9370 | 59 | None | 1 | 15 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm990387k | ||
| CHEMBL787 | 9370 | 59 | None | 1 | 15 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm990387k | ||
| DB00471 | 9370 | 59 | None | 1 | 15 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm990387k | ||
| 10100314 | 106803 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 613 | 9 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC/C(C)=C\C(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL286885 | 106803 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 613 | 9 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC/C(C)=C\C(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 10114089 | 74147 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(OCc2ccc(OCc3nn[nH]n3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18866 | 74147 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(OCc2ccc(OCc3nn[nH]n3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 10223216 | 74239 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(COc2ccc(OCc3ccc4ccccc4n3)cc2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18918 | 74239 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(COc2ccc(OCc3ccc4ccccc4n3)cc2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| 10349047 | 103444 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 629 | 10 | 2 | 6 | 5.9 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)(C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL26384 | 103444 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 629 | 10 | 2 | 6 | 5.9 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)(C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 2855 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00227-K | ||
| 3322 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00227-K | ||
| 5717 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00227-K | ||
| CHEMBL603 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00227-K | ||
| DB00549 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00227-K | ||
| 44214127 | 25657 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 526 | 10 | 2 | 5 | 5.1 | O=C(O)Cc1ccc(CCNS(=O)(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL128317 | 25657 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 526 | 10 | 2 | 5 | 5.1 | O=C(O)Cc1ccc(CCNS(=O)(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 10484810 | 102844 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 693 | 11 | 2 | 6 | 6.4 | CCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3Br)cc1OC)cn2C)CC(F)(F)F | 10.1021/jm00035a008 | ||
| CHEMBL26002 | 102844 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 693 | 11 | 2 | 6 | 6.4 | CCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3Br)cc1OC)cn2C)CC(F)(F)F | 10.1021/jm00035a008 | ||
| 22241529 | 75008 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 457 | 8 | 1 | 6 | 5.2 | Clc1ccc2ccc(COc3ccc(OCc4ccccc4Cc4nnn[nH]4)cc3)nc2c1 | 10.1021/jm00166a017 | ||
| CHEMBL19158 | 75008 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 457 | 8 | 1 | 6 | 5.2 | Clc1ccc2ccc(COc3ccc(OCc4ccccc4Cc4nnn[nH]4)cc3)nc2c1 | 10.1021/jm00166a017 | ||
| 44272197 | 173810 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 453 | 7 | 1 | 5 | 5.7 | Clc1ccc2ccc(/C=C/c3ccc(OCc4ccccc4Cc4nnn[nH]4)cc3)nc2c1 | 10.1021/jm00166a017 | ||
| CHEMBL428868 | 173810 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 453 | 7 | 1 | 5 | 5.7 | Clc1ccc2ccc(/C=C/c3ccc(OCc4ccccc4Cc4nnn[nH]4)cc3)nc2c1 | 10.1021/jm00166a017 | ||
| 15675872 | 186144 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 475 | 6 | 1 | 7 | 5.2 | O=C1CC(c2nnn[nH]2)Oc2cc(/C=C/c3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| CHEMBL47376 | 186144 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 475 | 6 | 1 | 7 | 5.2 | O=C1CC(c2nnn[nH]2)Oc2cc(/C=C/c3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | ||
| 14842364 | 129898 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 473 | 6 | 1 | 7 | 5.3 | O=c1cc(-c2nn[nH]n2)oc2cc(/C=C/c3cccc(OCc4ccc5ccccc5n4)c3)ccc12 | 10.1021/jm970180w | ||
| CHEMBL36113 | 129898 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 473 | 6 | 1 | 7 | 5.3 | O=c1cc(-c2nn[nH]n2)oc2cc(/C=C/c3cccc(OCc4ccc5ccccc5n4)c3)ccc12 | 10.1021/jm970180w | ||
| 10372164 | 30778 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 657 | 13 | 2 | 6 | 7.4 | CCC(CC)CNC(=O)c1ccc2c(CC3CCCCC3)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| CHEMBL133788 | 30778 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 657 | 13 | 2 | 6 | 7.4 | CCC(CC)CNC(=O)c1ccc2c(CC3CCCCC3)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| 10077724 | 30311 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 629 | 12 | 2 | 6 | 6.9 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C1CCCC1 | 10.1021/jm00055a011 | ||
| CHEMBL133398 | 30311 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 629 | 12 | 2 | 6 | 6.9 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C1CCCC1 | 10.1021/jm00055a011 | ||
| 10348138 | 175072 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.6 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| CHEMBL434053 | 175072 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.6 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| 10075131 | 25704 | 2 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 512 | 9 | 2 | 5 | 5.2 | O=C(O)c1ccc(CCNS(=O)(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL128583 | 25704 | 2 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 512 | 9 | 2 | 5 | 5.2 | O=C(O)c1ccc(CCNS(=O)(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 9804436 | 27411 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1ccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL130846 | 27411 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1ccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 15015300 | 105282 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(COc2ccc(-c3nn[nH]n3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL276136 | 105282 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(COc2ccc(-c3nn[nH]n3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 10158418 | 72917 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18413 | 72917 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| 9870702 | 107057 | 13 | None | 1 | 2 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 502 | 6 | 0 | 5 | 7.7 | Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)cc1 | 10.1016/0960-894X(95)00227-K | ||
| CHEMBL28902 | 107057 | 13 | None | 1 | 2 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 502 | 6 | 0 | 5 | 7.7 | Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)cc1 | 10.1016/0960-894X(95)00227-K | ||
| 14708738 | 196477 | 0 | None | - | 1 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 406 | 7 | 2 | 4 | 4.9 | COc1cc(C(=O)O)ccc1Cn1ccc2ccc(NC(=O)CC3CCCC3)cc21 | 10.1021/jm00168a037 | ||
| CHEMBL51544 | 196477 | 0 | None | - | 1 | Guinea pig | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 406 | 7 | 2 | 4 | 4.9 | COc1cc(C(=O)O)ccc1Cn1ccc2ccc(NC(=O)CC3CCCC3)cc21 | 10.1021/jm00168a037 | ||
| 44352288 | 124125 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 477 | 10 | 1 | 4 | 7.1 | O=C(O)c1ccc(CCCCOc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL339716 | 124125 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 477 | 10 | 1 | 4 | 7.1 | O=C(O)c1ccc(CCCCOc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 10225194 | 72040 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(-c2nn[nH]n2)ccc1OCc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a017 | ||
| CHEMBL18281 | 72040 | 0 | None | - | 1 | Guinea pig | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(-c2nn[nH]n2)ccc1OCc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a017 | ||
| 105007 | 103875 | 32 | None | - | 1 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00147a004 | ||
| CHEMBL267475 | 103875 | 32 | None | - | 1 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00147a004 | ||
| CHEMBL267976 | 103875 | 32 | None | - | 1 | Guinea pig | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00147a004 | ||
| 44277896 | 108463 | 1 | None | - | 1 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 4.0 | O[C@@H]1c2cc(OCc3cccc(Cl)n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00226-J | ||
| CHEMBL29937 | 108463 | 1 | None | - | 1 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 4.0 | O[C@@H]1c2cc(OCc3cccc(Cl)n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00226-J | ||
| 14626844 | 195663 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 408 | 6 | 3 | 4 | 5.0 | COc1cc(C(=O)O)ccc1Cc1c[nH]c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL50733 | 195663 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 408 | 6 | 3 | 4 | 5.0 | COc1cc(C(=O)O)ccc1Cc1c[nH]c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 44352209 | 25700 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 482 | 8 | 2 | 5 | 4.6 | O=C(O)c1ccc(CCNC(=O)C2CCc3ccc(OCc4ccc5ccccc5n4)cc3O2)cc1 | 10.1021/jm990387k | ||
| CHEMBL128548 | 25700 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 482 | 8 | 2 | 5 | 4.6 | O=C(O)c1ccc(CCNC(=O)C2CCc3ccc(OCc4ccc5ccccc5n4)cc3O2)cc1 | 10.1021/jm990387k | ||
| 14650373 | 70951 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 367 | 8 | 1 | 7 | 3.4 | c1ccc2sc(COc3ccc(OCCCc4nnn[nH]4)cc3)nc2c1 | 10.1021/jm00166a016 | ||
| CHEMBL18085 | 70951 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 367 | 8 | 1 | 7 | 3.4 | c1ccc2sc(COc3ccc(OCCCc4nnn[nH]4)cc3)nc2c1 | 10.1021/jm00166a016 | ||
| 14650381 | 72313 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 389 | 9 | 1 | 6 | 3.9 | CCc1ccc(OCc2ccc3ccccc3n2)cc1OCCCc1nnn[nH]1 | 10.1021/jm00166a016 | ||
| CHEMBL18309 | 72313 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 389 | 9 | 1 | 6 | 3.9 | CCc1ccc(OCc2ccc3ccccc3n2)cc1OCCCc1nnn[nH]1 | 10.1021/jm00166a016 | ||
| 10001437 | 106360 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 407 | 6 | 1 | 7 | 3.6 | Cc1nc(COc2ccc3c(c2)[C@@H](O)[C@@H](Cc2cccnc2)CO3)ccc1[N+](=O)[O-] | 10.1016/0960-894X(95)00226-J | ||
| CHEMBL283886 | 106360 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 407 | 6 | 1 | 7 | 3.6 | Cc1nc(COc2ccc3c(c2)[C@@H](O)[C@@H](Cc2cccnc2)CO3)ccc1[N+](=O)[O-] | 10.1016/0960-894X(95)00226-J | ||
| 9956127 | 176160 | 12 | None | - | 1 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 465 | 6 | 2 | 6 | 5.0 | O=C(O)c1cccc(C[C@@H]2COc3ccc(OCc4nc5cc(F)ccc5s4)cc3[C@@H]2O)c1 | 10.1016/0960-894X(95)00225-I | ||
| CHEMBL442150 | 176160 | 12 | None | - | 1 | Guinea pig | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 465 | 6 | 2 | 6 | 5.0 | O=C(O)c1cccc(C[C@@H]2COc3ccc(OCc4nc5cc(F)ccc5s4)cc3[C@@H]2O)c1 | 10.1016/0960-894X(95)00225-I | ||
| 126145 | 54627 | 7 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 488 | 18 | 2 | 4 | 7.2 | O=C(O)CCSC(SCCC(=O)O)c1ccccc1CCCCCCCCc1ccccc1 | 10.1021/jm00147a004 | ||
| CHEMBL15489 | 54627 | 7 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 488 | 18 | 2 | 4 | 7.2 | O=C(O)CCSC(SCCC(=O)O)c1ccccc1CCCCCCCCc1ccccc1 | 10.1021/jm00147a004 | ||
| 10258882 | 123302 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 665 | 14 | 2 | 6 | 7.1 | CCC(CC)CNC(=O)c1ccc2c(CCc3ccccc3)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| CHEMBL336194 | 123302 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 665 | 14 | 2 | 6 | 7.1 | CCC(CC)CNC(=O)c1ccc2c(CCc3ccccc3)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| 44285389 | 106761 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](Sc1ccccc1C(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL286626 | 106761 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](Sc1ccccc1C(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | ||
| 10345753 | 212743 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 496 | 8 | 1 | 6 | 5.3 | Clc1ccc2ccc(COc3ccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)cc3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| CHEMBL84552 | 212743 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 496 | 8 | 1 | 6 | 5.3 | Clc1ccc2ccc(COc3ccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)cc3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| 44352484 | 28260 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 450 | 8 | 2 | 6 | 3.9 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)NCc1ccc(-c2nn[nH]n2)cc1 | 10.1021/jm990387k | ||
| CHEMBL131582 | 28260 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 450 | 8 | 2 | 6 | 3.9 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)NCc1ccc(-c2nn[nH]n2)cc1 | 10.1021/jm990387k | ||
| 44285277 | 161540 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 512 | 19 | 3 | 4 | 7.4 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL40009 | 161540 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 512 | 19 | 3 | 4 | 7.4 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| 44353198 | 27545 | 0 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 422 | 9 | 2 | 4 | 4.7 | CCCc1cn(Cc2ccc(C(=O)O)cc2OC)c2cc(C(=O)NCC(C)C)ccc12 | 10.1021/jm00055a011 | ||
| CHEMBL130948 | 27545 | 0 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 422 | 9 | 2 | 4 | 4.7 | CCCc1cn(Cc2ccc(C(=O)O)cc2OC)c2cc(C(=O)NCC(C)C)ccc12 | 10.1021/jm00055a011 | ||
| 44352125 | 124003 | 0 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 469 | 13 | 2 | 5 | 5.0 | O=C(Cc1ccc(OCCCCc2ccccc2)cc1)Nc1ccc(CCCc2nnn[nH]2)cc1 | 10.1021/jm990387k | ||
| CHEMBL339461 | 124003 | 0 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 469 | 13 | 2 | 5 | 5.0 | O=C(Cc1ccc(OCCCCc2ccccc2)cc1)Nc1ccc(CCCc2nnn[nH]2)cc1 | 10.1021/jm990387k | ||
| 9948863 | 74797 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 317 | 5 | 1 | 5 | 2.9 | c1ccc2nc(COc3ccc(Cc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| CHEMBL19136 | 74797 | 0 | None | - | 1 | Guinea pig | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 317 | 5 | 1 | 5 | 2.9 | c1ccc2nc(COc3ccc(Cc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| 23224681 | 26258 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 486 | 7 | 2 | 6 | 5.1 | O=C(NCc1cccc(-c2nn[nH]n2)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL129893 | 26258 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 486 | 7 | 2 | 6 | 5.1 | O=C(NCc1cccc(-c2nn[nH]n2)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 14836105 | 18845 | 0 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 357 | 5 | 1 | 3 | 5.2 | C[C@H](C(=O)O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm00092a001 | ||
| CHEMBL1183712 | 18845 | 0 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 357 | 5 | 1 | 3 | 5.2 | C[C@H](C(=O)O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm00092a001 | ||
| CHEMBL314449 | 18845 | 0 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 357 | 5 | 1 | 3 | 5.2 | C[C@H](C(=O)O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm00092a001 | ||
| 3969 | 62676 | 46 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 318 | 9 | 2 | 6 | 2.5 | CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O | 10.1021/jm00168a037 | ||
| CHEMBL162358 | 62676 | 46 | None | - | 1 | Guinea pig | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 318 | 9 | 2 | 6 | 2.5 | CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O | 10.1021/jm00168a037 | ||
| 44352119 | 27598 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1cccc(-c2nn[nH]n2)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL131008 | 27598 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1cccc(-c2nn[nH]n2)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 44352157 | 26217 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 468 | 10 | 1 | 4 | 5.4 | CN(C(=O)Cc1ccc(OCc2ccc3ccccc3n2)cc1)c1ccc(CCCC(=O)O)cc1 | 10.1021/jm990387k | ||
| CHEMBL129570 | 26217 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 468 | 10 | 1 | 4 | 5.4 | CN(C(=O)Cc1ccc(OCc2ccc3ccccc3n2)cc1)c1ccc(CCCC(=O)O)cc1 | 10.1021/jm990387k | ||
| 129044 | 73173 | 26 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc(Cc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18518 | 73173 | 26 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc(Cc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00166a017 | ||
| 129044 | 73173 | 26 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc(Cc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00109a025 | ||
| CHEMBL18518 | 73173 | 26 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc(Cc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00109a025 | ||
| 10050711 | 117159 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 477 | 7 | 1 | 8 | 4.7 | O=c1cc(-c2nn[nH]n2)oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc12 | 10.1021/jm970180w | ||
| CHEMBL32426 | 117159 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 477 | 7 | 1 | 8 | 4.7 | O=c1cc(-c2nn[nH]n2)oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc12 | 10.1021/jm970180w | ||
| 129044 | 73173 | 26 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc(Cc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00108a001 | ||
| CHEMBL18518 | 73173 | 26 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc(Cc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00108a001 | ||
| 10438378 | 27764 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 589 | 12 | 2 | 6 | 5.9 | CCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| CHEMBL131148 | 27764 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 589 | 12 | 2 | 6 | 5.9 | CCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| 10438054 | 98981 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3CCCC3)cc12 | 10.1021/jm00055a011 | ||
| CHEMBL24256 | 98981 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3CCCC3)cc12 | 10.1021/jm00055a011 | ||
| 10438054 | 98981 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3CCCC3)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL24256 | 98981 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 573 | 9 | 2 | 6 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3CCCC3)cc12 | 10.1021/jm00035a008 | ||
| 10223827 | 105243 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 419 | 7 | 1 | 5 | 5.1 | C(=C/c1ccc2ccccc2n1)\c1ccc(OCc2ccccc2Cc2nnn[nH]2)cc1 | 10.1021/jm00166a017 | ||
| CHEMBL275866 | 105243 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 419 | 7 | 1 | 5 | 5.1 | C(=C/c1ccc2ccccc2n1)\c1ccc(OCc2ccccc2Cc2nnn[nH]2)cc1 | 10.1021/jm00166a017 | ||
| 10074704 | 172084 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 500 | 8 | 2 | 6 | 5.1 | O=C(NCCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| CHEMBL423333 | 172084 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 500 | 8 | 2 | 6 | 5.1 | O=C(NCCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| 44352452 | 25720 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 540 | 9 | 2 | 5 | 5.9 | CC(C)(CNS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccc(C(=O)O)cc1 | 10.1021/jm990387k | ||
| CHEMBL128641 | 25720 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 540 | 9 | 2 | 5 | 5.9 | CC(C)(CNS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccc(C(=O)O)cc1 | 10.1021/jm990387k | ||
| 10348808 | 103380 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 613 | 10 | 2 | 6 | 5.4 | C=C(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C)CC(F)(F)F | 10.1021/jm00035a008 | ||
| CHEMBL26332 | 103380 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 613 | 10 | 2 | 6 | 5.4 | C=C(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C)CC(F)(F)F | 10.1021/jm00035a008 | ||
| 44353313 | 123244 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 639 | 11 | 2 | 6 | 6.1 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4Br)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| CHEMBL336101 | 123244 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 639 | 11 | 2 | 6 | 6.1 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4Br)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| 44353268 | 123440 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 589 | 13 | 2 | 6 | 5.9 | CCCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| CHEMBL337059 | 123440 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 589 | 13 | 2 | 6 | 5.9 | CCCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| 44292483 | 182609 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 483 | 8 | 0 | 7 | 5.3 | CCOC(=O)C1CC(=O)c2ccc(COc3cccc(OCc4ccc5ccccc5n4)c3)cc2O1 | 10.1021/jm00109a025 | ||
| CHEMBL45850 | 182609 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 483 | 8 | 0 | 7 | 5.3 | CCOC(=O)C1CC(=O)c2ccc(COc3cccc(OCc4ccc5ccccc5n4)c3)cc2O1 | 10.1021/jm00109a025 | ||
| 44352385 | 25746 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 516 | 6 | 2 | 6 | 6.0 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| CHEMBL128771 | 25746 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 516 | 6 | 2 | 6 | 6.0 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| 44352384 | 26128 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 458 | 6 | 1 | 4 | 6.7 | O=C(O)c1ccc2c(ccn2Cc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)c1 | 10.1021/jm990387k | ||
| CHEMBL129079 | 26128 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 458 | 6 | 1 | 4 | 6.7 | O=C(O)c1ccc2c(ccn2Cc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)c1 | 10.1021/jm990387k | ||
| 44352326 | 27620 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3cc(OCc4ccc5ccccc5n4)ccc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL131025 | 27620 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3cc(OCc4ccc5ccccc5n4)ccc3c2)cc1 | 10.1021/jm990387k | ||
| 10223215 | 72386 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1ccc2nc(COc3ccc(COc4ccc(-c5nn[nH]n5)cc4)cc3)ccc2c1 | 10.1021/jm00166a017 | ||
| CHEMBL18339 | 72386 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1ccc2nc(COc3ccc(COc4ccc(-c5nn[nH]n5)cc4)cc3)ccc2c1 | 10.1021/jm00166a017 | ||
| 14650348 | 72003 | 1 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 377 | 8 | 1 | 6 | 4.1 | c1ccc2nc(COc3ccc(SCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| CHEMBL18265 | 72003 | 1 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 377 | 8 | 1 | 6 | 4.1 | c1ccc2nc(COc3ccc(SCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| 14650342 | 105632 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 476 | 10 | 1 | 6 | 4.5 | O=C(CCCOc1ccc(OCc2ccc3ccccc3n2)cc1)NS(=O)(=O)c1ccccc1 | 10.1021/jm00166a016 | ||
| CHEMBL278920 | 105632 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 476 | 10 | 1 | 6 | 4.5 | O=C(CCCOc1ccc(OCc2ccc3ccccc3n2)cc1)NS(=O)(=O)c1ccccc1 | 10.1021/jm00166a016 | ||
| 15337938 | 212689 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 492 | 7 | 1 | 5 | 5.9 | Clc1ccc2ccc(/C=C/c3ccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)cc3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| CHEMBL84025 | 212689 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 492 | 7 | 1 | 5 | 5.9 | Clc1ccc2ccc(/C=C/c3ccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)cc3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| 44285563 | 160231 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 528 | 20 | 3 | 5 | 7.2 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCOc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL39794 | 160231 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 528 | 20 | 3 | 5 | 7.2 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCOc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| 44285014 | 169420 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 498 | 18 | 3 | 4 | 7.0 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL416973 | 169420 | 0 | None | - | 1 | Guinea pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 498 | 18 | 3 | 4 | 7.0 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| 14501729 | 72995 | 0 | None | - | 1 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1ccc(OCc2ccc3ccccc3n2)c(OCCCc2nnn[nH]2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL18450 | 72995 | 0 | None | - | 1 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1ccc(OCc2ccc3ccccc3n2)c(OCCCc2nnn[nH]2)c1 | 10.1021/jm00166a016 | ||
| 9848518 | 114067 | 5 | None | 1 | 2 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 492 | 6 | 0 | 6 | 7.2 | Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3nc4cc(F)ccc4s3)c2)cc1 | 10.1016/0960-894X(95)00227-K | ||
| CHEMBL31714 | 114067 | 5 | None | 1 | 2 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 492 | 6 | 0 | 6 | 7.2 | Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3nc4cc(F)ccc4s3)c2)cc1 | 10.1016/0960-894X(95)00227-K | ||
| 44352109 | 123461 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 516 | 8 | 4 | 7 | 5.2 | CC(C(=O)Nc1ccc(CC2=NNNN2)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL337162 | 123461 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 516 | 8 | 4 | 7 | 5.2 | CC(C(=O)Nc1ccc(CC2=NNNN2)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 60539 | 66765 | 13 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 382 | 5 | 1 | 4 | 4.1 | O=S(=O)(Nc1cccc(OCc2ccc3ccccc3n2)c1)C(F)(F)F | 10.1021/jm00166a017 | ||
| CHEMBL17344 | 66765 | 13 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 382 | 5 | 1 | 4 | 4.1 | O=S(=O)(Nc1cccc(OCc2ccc3ccccc3n2)c1)C(F)(F)F | 10.1021/jm00166a017 | ||
| 60539 | 66765 | 13 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 382 | 5 | 1 | 4 | 4.1 | O=S(=O)(Nc1cccc(OCc2ccc3ccccc3n2)c1)C(F)(F)F | 10.1021/jm00108a001 | ||
| CHEMBL17344 | 66765 | 13 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 382 | 5 | 1 | 4 | 4.1 | O=S(=O)(Nc1cccc(OCc2ccc3ccccc3n2)c1)C(F)(F)F | 10.1021/jm00108a001 | ||
| 44352450 | 26251 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 490 | 8 | 2 | 4 | 6.3 | CC(C(=O)Nc1ccc(CC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL129866 | 26251 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 490 | 8 | 2 | 4 | 6.3 | CC(C(=O)Nc1ccc(CC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 44352264 | 25694 | 0 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 456 | 10 | 2 | 4 | 5.4 | CC(C(=O)NCCCCC(=O)O)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL128531 | 25694 | 0 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 456 | 10 | 2 | 4 | 5.4 | CC(C(=O)NCCCCC(=O)O)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 129968 | 170034 | 15 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL418551 | 170034 | 15 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| 44352354 | 25627 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 518 | 10 | 2 | 4 | 7.1 | CC(C(=O)Nc1ccc(CCCC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL128164 | 25627 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 518 | 10 | 2 | 4 | 7.1 | CC(C(=O)Nc1ccc(CCCC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 14650340 | 73958 | 1 | None | - | 1 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 307 | 7 | 0 | 3 | 5.0 | CCCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL18775 | 73958 | 1 | None | - | 1 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 307 | 7 | 0 | 3 | 5.0 | CCCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| 44352172 | 123325 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 495 | 10 | 2 | 6 | 5.5 | O=C(O)c1ccc(OCC(O)COc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL336298 | 123325 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 495 | 10 | 2 | 6 | 5.5 | O=C(O)c1ccc(OCC(O)COc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 44352462 | 122156 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | CC(Cc1ccc(C(=O)O)cc1)NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| CHEMBL335000 | 122156 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | CC(Cc1ccc(C(=O)O)cc1)NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| 10394121 | 106566 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 621 | 10 | 2 | 6 | 5.8 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cn1ccc2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | ||
| CHEMBL285300 | 106566 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 621 | 10 | 2 | 6 | 5.8 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cn1ccc2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | ||
| 15015281 | 73550 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(-c2nn[nH]n2)ccc1COc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18589 | 73550 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(-c2nn[nH]n2)ccc1COc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 44352294 | 170220 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1cccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)c1 | 10.1021/jm990387k | ||
| CHEMBL419796 | 170220 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1cccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)c1 | 10.1021/jm990387k | ||
| 10416524 | 100063 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 627 | 10 | 2 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3(CC(F)(F)F)CC3)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL24506 | 100063 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 627 | 10 | 2 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3(CC(F)(F)F)CC3)cc12 | 10.1021/jm00035a008 | ||
| 9985579 | 105912 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.4 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00035a008 | ||
| CHEMBL281066 | 105912 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.4 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00035a008 | ||
| 9870130 | 25766 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 488 | 10 | 2 | 4 | 6.1 | O=C(O)CCCc1ccc(NC(=O)Cc2ccc(OCc3ccc4ccc(Cl)cc4n3)cc2)cc1 | 10.1021/jm990387k | ||
| CHEMBL128794 | 25766 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 488 | 10 | 2 | 4 | 6.1 | O=C(O)CCCc1ccc(NC(=O)Cc2ccc(OCc3ccc4ccc(Cl)cc4n3)cc2)cc1 | 10.1021/jm990387k | ||
| 10416647 | 106400 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 635 | 10 | 2 | 6 | 6.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cn1cc(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | ||
| CHEMBL284128 | 106400 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 635 | 10 | 2 | 6 | 6.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cn1cc(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | ||
| 9952064 | 74327 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 385 | 7 | 1 | 4 | 5.1 | O=C(O)c1cccc(COc2cccc(OCc3ccc4ccccc4n3)c2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18979 | 74327 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 385 | 7 | 1 | 4 | 5.1 | O=C(O)c1cccc(COc2cccc(OCc3ccc4ccccc4n3)c2)c1 | 10.1021/jm00166a017 | ||
| 44352118 | 28040 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 454 | 10 | 2 | 4 | 5.4 | O=C(O)CCCc1ccc(NC(=O)Cc2cccc(OCc3ccc4ccccc4n3)c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL131345 | 28040 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 454 | 10 | 2 | 4 | 5.4 | O=C(O)CCCc1ccc(NC(=O)Cc2cccc(OCc3ccc4ccccc4n3)c2)cc1 | 10.1021/jm990387k | ||
| 6917955 | 86692 | 1 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc([C@@H](O)[C@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | ||
| CHEMBL21247 | 86692 | 1 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc([C@@H](O)[C@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | ||
| 44286706 | 21388 | 0 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc(C(O)[C@@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00159a003 | ||
| CHEMBL1205015 | 21388 | 0 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc(C(O)[C@@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00159a003 | ||
| CHEMBL41301 | 21388 | 0 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc(C(O)[C@@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00159a003 | ||
| 14626846 | 195473 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 5.1 | COCCn1cc(Cc2ccc(C(=O)O)cc2OC)c2cc(NC(=O)OC3CCCC3)ccc21 | 10.1021/jm00168a037 | ||
| CHEMBL50422 | 195473 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 5.1 | COCCn1cc(Cc2ccc(C(=O)O)cc2OC)c2cc(NC(=O)OC3CCCC3)ccc21 | 10.1021/jm00168a037 | ||
| 44382463 | 65998 | 0 | None | 9 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | ||
| CHEMBL170226 | 65998 | 0 | None | 9 | 2 | Guinea pig | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | ||
| 129968 | 170034 | 15 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL418551 | 170034 | 15 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| 44352142 | 25625 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 454 | 10 | 2 | 4 | 5.2 | O=C(O)CCCc1ccc(C(=O)NCc2ccc(OCc3ccc4ccccc4n3)cc2)cc1 | 10.1021/jm990387k | ||
| CHEMBL128151 | 25625 | 0 | None | - | 1 | Guinea pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 454 | 10 | 2 | 4 | 5.2 | O=C(O)CCCc1ccc(C(=O)NCc2ccc(OCc3ccc4ccccc4n3)cc2)cc1 | 10.1021/jm990387k | ||
| 126144 | 53177 | 6 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 468 | 20 | 2 | 4 | 7.6 | CCCCCCCCCCCCc1ccccc1C(SCCC(=O)O)SCCC(=O)O | 10.1021/jm00147a004 | ||
| CHEMBL15367 | 53177 | 6 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 468 | 20 | 2 | 4 | 7.6 | CCCCCCCCCCCCc1ccccc1C(SCCC(=O)O)SCCC(=O)O | 10.1021/jm00147a004 | ||
| 3334 | 9921 | 9 | None | 5 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00389a001 | ||
| 60842 | 9921 | 9 | None | 5 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00389a001 | ||
| CHEMBL22776 | 9921 | 9 | None | 5 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00389a001 | ||
| 3334 | 9921 | 9 | None | 5 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00108a001 | ||
| 60842 | 9921 | 9 | None | 5 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00108a001 | ||
| CHEMBL22776 | 9921 | 9 | None | 5 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00108a001 | ||
| 3334 | 9921 | 9 | None | 5 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00168a037 | ||
| 60842 | 9921 | 9 | None | 5 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00168a037 | ||
| CHEMBL22776 | 9921 | 9 | None | 5 | 2 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00168a037 | ||
| 10461845 | 106793 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 643 | 12 | 2 | 6 | 6.3 | CCCCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C)C(F)(F)F | 10.1021/jm00035a008 | ||
| CHEMBL286827 | 106793 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 643 | 12 | 2 | 6 | 6.3 | CCCCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C)C(F)(F)F | 10.1021/jm00035a008 | ||
| 14948496 | 100255 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 561 | 10 | 2 | 6 | 5.0 | CCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| CHEMBL24613 | 100255 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 561 | 10 | 2 | 6 | 5.0 | CCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| 9870316 | 212531 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 492 | 7 | 1 | 5 | 5.9 | Clc1ccc2ccc(/C=C/c3cccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)c3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| CHEMBL82758 | 212531 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 492 | 7 | 1 | 5 | 5.9 | Clc1ccc2ccc(/C=C/c3cccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)c3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| 15337936 | 212697 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 494 | 7 | 1 | 6 | 5.7 | Clc1ccc2ccc(/C=C/c3cccc(CN4CCc5cccc(OCc6nn[nH]n6)c54)c3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| CHEMBL84089 | 212697 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 494 | 7 | 1 | 6 | 5.7 | Clc1ccc2ccc(/C=C/c3cccc(CN4CCc5cccc(OCc6nn[nH]n6)c54)c3)nc2c1 | 10.1016/0960-894X(96)00013-3 | ||
| 14948496 | 100255 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 561 | 10 | 2 | 6 | 5.0 | CCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00035a008 | ||
| CHEMBL24613 | 100255 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 561 | 10 | 2 | 6 | 5.0 | CCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00035a008 | ||
| 9909426 | 74074 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(COc2cccc(-c3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18833 | 74074 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(COc2cccc(-c3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 10031940 | 26249 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 629 | 11 | 2 | 6 | 5.9 | CCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C)CC(F)(F)F | 10.1021/jm00035a008 | ||
| CHEMBL12985 | 26249 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 629 | 11 | 2 | 6 | 5.9 | CCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C)CC(F)(F)F | 10.1021/jm00035a008 | ||
| 10394230 | 67819 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 629 | 11 | 2 | 6 | 6.0 | CCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2CC)C(F)(F)F | 10.1021/jm00035a008 | ||
| CHEMBL176286 | 67819 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 629 | 11 | 2 | 6 | 6.0 | CCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2CC)C(F)(F)F | 10.1021/jm00035a008 | ||
| 10481103 | 25611 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 500 | 8 | 2 | 6 | 5.0 | O=C(Cc1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1)NCc1ccc(-c2nn[nH]n2)cc1 | 10.1021/jm990387k | ||
| CHEMBL128068 | 25611 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 500 | 8 | 2 | 6 | 5.0 | O=C(Cc1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1)NCc1ccc(-c2nn[nH]n2)cc1 | 10.1021/jm990387k | ||
| 9847235 | 27992 | 3 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 463 | 9 | 1 | 4 | 6.7 | O=C(O)c1ccc(CCCOc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL131304 | 27992 | 3 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 463 | 9 | 1 | 4 | 6.7 | O=C(O)c1ccc(CCCOc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 14708752 | 194466 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 407 | 7 | 2 | 5 | 4.3 | COc1cc(C(=O)O)ccc1Cn1ncc2ccc(NC(=O)CC3CCCC3)cc21 | 10.1021/jm00168a037 | ||
| CHEMBL49519 | 194466 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 407 | 7 | 2 | 5 | 4.3 | COc1cc(C(=O)O)ccc1Cn1ncc2ccc(NC(=O)CC3CCCC3)cc21 | 10.1021/jm00168a037 | ||
| 10371402 | 28200 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 601 | 12 | 2 | 6 | 6.3 | C/C=C\c1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| CHEMBL131514 | 28200 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 601 | 12 | 2 | 6 | 6.3 | C/C=C\c1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| 9890545 | 212661 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 462 | 8 | 1 | 6 | 4.7 | c1cc(CN2CCc3cccc(CCc4nnn[nH]4)c32)cc(OCc2ccc3ccccc3n2)c1 | 10.1016/0960-894X(96)00013-3 | ||
| CHEMBL83851 | 212661 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 462 | 8 | 1 | 6 | 4.7 | c1cc(CN2CCc3cccc(CCc4nnn[nH]4)c32)cc(OCc2ccc3ccccc3n2)c1 | 10.1016/0960-894X(96)00013-3 | ||
| 14650371 | 73021 | 0 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 362 | 8 | 1 | 7 | 2.7 | c1ccc2nc(COc3ccc(OCCCc4nnn[nH]4)cc3)ncc2c1 | 10.1021/jm00166a016 | ||
| CHEMBL18459 | 73021 | 0 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 362 | 8 | 1 | 7 | 2.7 | c1ccc2nc(COc3ccc(OCCCc4nnn[nH]4)cc3)ncc2c1 | 10.1021/jm00166a016 | ||
| 9951001 | 73087 | 0 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 365 | 9 | 0 | 5 | 4.5 | CCOC(=O)CCCOc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a016 | ||
| CHEMBL18490 | 73087 | 0 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 365 | 9 | 0 | 5 | 4.5 | CCOC(=O)CCCOc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a016 | ||
| 44285448 | 127884 | 0 | None | - | 1 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 568 | 23 | 3 | 4 | 8.9 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL35731 | 127884 | 0 | None | - | 1 | Guinea pig | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 568 | 23 | 3 | 4 | 8.9 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| 105007 | 103875 | 32 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00166a017 | ||
| CHEMBL267475 | 103875 | 32 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00166a017 | ||
| CHEMBL267976 | 103875 | 32 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00166a017 | ||
| 105007 | 103875 | 32 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00109a025 | ||
| CHEMBL267475 | 103875 | 32 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00109a025 | ||
| CHEMBL267976 | 103875 | 32 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00109a025 | ||
| 14650359 | 74666 | 1 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 377 | 8 | 1 | 6 | 4.1 | c1ccc2nc(CSc3ccc(OCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| CHEMBL19106 | 74666 | 1 | None | - | 1 | Guinea pig | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 377 | 8 | 1 | 6 | 4.1 | c1ccc2nc(CSc3ccc(OCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| 6518171 | 175075 | 55 | None | -4 | 8 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 495 | 12 | 2 | 6 | 4.9 | CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 | nan | ||
| CHEMBL434063 | 175075 | 55 | None | -4 | 8 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 495 | 12 | 2 | 6 | 4.9 | CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 | nan | ||
| 14626845 | 171703 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 450 | 8 | 2 | 5 | 5.8 | CCCn1cc(Cc2ccc(C(=O)O)cc2OC)c2cc(NC(=O)OC3CCCC3)ccc21 | 10.1021/jm00168a037 | ||
| CHEMBL422404 | 171703 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 450 | 8 | 2 | 5 | 5.8 | CCCn1cc(Cc2ccc(C(=O)O)cc2OC)c2cc(NC(=O)OC3CCCC3)ccc21 | 10.1021/jm00168a037 | ||
| 44352130 | 28194 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.8 | O=C(Nc1ccc(CCCc2nnn[nH]2)cc1)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm990387k | ||
| CHEMBL131502 | 28194 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.8 | O=C(Nc1ccc(CCCc2nnn[nH]2)cc1)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm990387k | ||
| 15675886 | 107920 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2cc(COc3ccc(OCc4ccc5ccccc5n4)cc3)ccc21 | 10.1021/jm00109a025 | ||
| CHEMBL295368 | 107920 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2cc(COc3ccc(OCc4ccc5ccccc5n4)cc3)ccc21 | 10.1021/jm00109a025 | ||
| 10482604 | 26545 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 547 | 9 | 2 | 6 | 4.6 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)C)cc12 | 10.1021/jm00055a011 | ||
| CHEMBL130140 | 26545 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 547 | 9 | 2 | 6 | 4.6 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)C)cc12 | 10.1021/jm00055a011 | ||
| 44353314 | 30400 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 595 | 11 | 2 | 6 | 5.9 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4Cl)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| CHEMBL133462 | 30400 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 595 | 11 | 2 | 6 | 5.9 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4Cl)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| 10438821 | 124258 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 617 | 13 | 2 | 6 | 6.5 | CCC(CC)CNC(=O)c1ccc2c(CC(C)C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| CHEMBL339958 | 124258 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 617 | 13 | 2 | 6 | 6.5 | CCC(CC)CNC(=O)c1ccc2c(CC(C)C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | ||
| 10325810 | 29161 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.4 | CCCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| CHEMBL132449 | 29161 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 575 | 11 | 2 | 6 | 5.4 | CCCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| 10461263 | 168516 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| CHEMBL413742 | 168516 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| 6436135 | 106348 | 43 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 412 | 9 | 2 | 4 | 5.8 | CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O | 10.1021/jm970180w | ||
| CHEMBL283754 | 106348 | 43 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 412 | 9 | 2 | 4 | 5.8 | CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O | 10.1021/jm970180w | ||
| 9803418 | 67244 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 442 | 16 | 2 | 3 | 6.5 | O=C(O)CCSC(CC(=O)O)c1ccccc1CCCCCCCCc1ccccc1 | 10.1021/jm00389a001 | ||
| CHEMBL175401 | 67244 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 442 | 16 | 2 | 3 | 6.5 | O=C(O)CCSC(CC(=O)O)c1ccccc1CCCCCCCCc1ccccc1 | 10.1021/jm00389a001 | ||
| 9868007 | 88225 | 4 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 442 | 16 | 2 | 3 | 6.5 | O=C(O)CCS[C@@H](CC(=O)O)c1ccccc1CCCCCCCCc1ccccc1 | 10.1021/jm00108a001 | ||
| CHEMBL21595 | 88225 | 4 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 442 | 16 | 2 | 3 | 6.5 | O=C(O)CCS[C@@H](CC(=O)O)c1ccccc1CCCCCCCCc1ccccc1 | 10.1021/jm00108a001 | ||
| 3969 | 62676 | 46 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 318 | 9 | 2 | 6 | 2.5 | CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O | 10.1021/jm00092a001 | ||
| CHEMBL162358 | 62676 | 46 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 318 | 9 | 2 | 6 | 2.5 | CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O | 10.1021/jm00092a001 | ||
| 3969 | 62676 | 46 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 318 | 9 | 2 | 6 | 2.5 | CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | ||
| CHEMBL162358 | 62676 | 46 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 318 | 9 | 2 | 6 | 2.5 | CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | ||
| 10437821 | 123300 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 561 | 9 | 1 | 6 | 4.9 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)N(C)CC(C)C)cc12 | 10.1021/jm00055a011 | ||
| CHEMBL336183 | 123300 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 561 | 9 | 1 | 6 | 4.9 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)N(C)CC(C)C)cc12 | 10.1021/jm00055a011 | ||
| 10026794 | 26972 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 450 | 11 | 2 | 4 | 5.5 | CCCc1cn(Cc2ccc(C(=O)O)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| CHEMBL130495 | 26972 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 450 | 11 | 2 | 4 | 5.5 | CCCc1cn(Cc2ccc(C(=O)O)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | ||
| 44285289 | 107273 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 514 | 19 | 3 | 5 | 6.8 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCOc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| CHEMBL291032 | 107273 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 514 | 19 | 3 | 5 | 6.8 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCOc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | ||
| 9885950 | 105168 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 375 | 8 | 1 | 6 | 3.6 | Cc1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL275385 | 105168 | 0 | None | - | 1 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 375 | 8 | 1 | 6 | 3.6 | Cc1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| 9800998 | 106144 | 2 | None | 32 | 2 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00225-I | ||
| CHEMBL282524 | 106144 | 2 | None | 32 | 2 | Guinea pig | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00225-I | ||
| 44352422 | 123365 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 490 | 8 | 2 | 4 | 6.1 | CC(C(=O)NCc1cccc(C(=O)O)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL336606 | 123365 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 490 | 8 | 2 | 4 | 6.1 | CC(C(=O)NCc1cccc(C(=O)O)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 10808580 | 106944 | 0 | None | - | 1 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 5.6 | CCCCC1CCc2ccc(OCc3ccc4ccccc4n3)cc2C1O | 10.1016/0960-894X(95)00225-I | ||
| CHEMBL28797 | 106944 | 0 | None | - | 1 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 361 | 6 | 1 | 3 | 5.6 | CCCCC1CCc2ccc(OCc3ccc4ccccc4n3)cc2C1O | 10.1016/0960-894X(95)00225-I | ||
| 9906952 | 214777 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1ccc2nc(COc3ccc(OCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| CHEMBL97287 | 214777 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1ccc2nc(COc3ccc(OCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | ||
| 44272233 | 105754 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL279849 | 105754 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| 10202522 | 72900 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(OCc2ccc(Cc3nnn[nH]3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18405 | 72900 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(OCc2ccc(Cc3nnn[nH]3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 44352148 | 25583 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 449 | 8 | 1 | 4 | 6.4 | O=C(O)c1ccc(COCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL127842 | 25583 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 449 | 8 | 1 | 4 | 6.4 | O=C(O)c1ccc(COCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 44352151 | 25664 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 454 | 10 | 2 | 4 | 5.4 | O=C(O)CCCc1ccc(NC(=O)Cc2ccc(OCc3ccc4ccccc4n3)cc2)cc1 | 10.1021/jm990387k | ||
| CHEMBL128364 | 25664 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 454 | 10 | 2 | 4 | 5.4 | O=C(O)CCCc1ccc(NC(=O)Cc2ccc(OCc3ccc4ccccc4n3)cc2)cc1 | 10.1021/jm990387k | ||
| 10348846 | 103304 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCC(C)C(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL26284 | 103304 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCC(C)C(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 44272084 | 72889 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(OCc2ccc(OCc3ccc4ccccc4n3)cc2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18396 | 72889 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(OCc2ccc(OCc3ccc4ccccc4n3)cc2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| 10371399 | 102522 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 601 | 10 | 2 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCCC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| CHEMBL25841 | 102522 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 601 | 10 | 2 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCCC(F)(F)F)cc12 | 10.1021/jm00035a008 | ||
| 10348586 | 106427 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 601 | 10 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cn1ccc2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | ||
| CHEMBL284322 | 106427 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 601 | 10 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cn1ccc2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | ||
| 23224651 | 25684 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 486 | 7 | 2 | 6 | 5.1 | O=C(NCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| CHEMBL128477 | 25684 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 486 | 7 | 2 | 6 | 5.1 | O=C(NCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | ||
| 44353320 | 171810 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 561 | 11 | 2 | 6 | 5.2 | CCCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2OC)c2cc(C(=O)NCC(C)C)ccc12 | 10.1021/jm00055a011 | ||
| CHEMBL422616 | 171810 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 561 | 11 | 2 | 6 | 5.2 | CCCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2OC)c2cc(C(=O)NCC(C)C)ccc12 | 10.1021/jm00055a011 | ||
| 10100380 | 27802 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 617 | 14 | 2 | 6 | 6.5 | CCCCCCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| CHEMBL131173 | 27802 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 617 | 14 | 2 | 6 | 6.5 | CCCCCCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| 44352424 | 27791 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 490 | 8 | 2 | 4 | 6.1 | CC(C(=O)NCc1ccc(C(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL131166 | 27791 | 0 | None | - | 1 | Guinea pig | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 490 | 8 | 2 | 4 | 6.1 | CC(C(=O)NCc1ccc(C(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 44292283 | 184048 | 0 | None | - | 1 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 347 | 4 | 1 | 5 | 3.6 | O=C(O)c1cc(=O)c2ccc(OCc3ccc4ccccc4n3)cc2o1 | 10.1021/jm00109a025 | ||
| CHEMBL46362 | 184048 | 0 | None | - | 1 | Guinea pig | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 347 | 4 | 1 | 5 | 3.6 | O=C(O)c1cc(=O)c2ccc(OCc3ccc4ccccc4n3)cc2o1 | 10.1021/jm00109a025 | ||
| 44278454 | 106660 | 0 | None | -2 | 2 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 468 | 6 | 0 | 5 | 7.0 | Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3ccc4ccccc4n3)c2)cc1 | 10.1016/0960-894X(95)00227-K | ||
| CHEMBL28595 | 106660 | 0 | None | -2 | 2 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 468 | 6 | 0 | 5 | 7.0 | Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3ccc4ccccc4n3)c2)cc1 | 10.1016/0960-894X(95)00227-K | ||
| 9820984 | 73485 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 375 | 9 | 1 | 6 | 3.7 | c1cc(OCCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL18558 | 73485 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 375 | 9 | 1 | 6 | 3.7 | c1cc(OCCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | ||
| 44352316 | 29026 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 502 | 9 | 2 | 4 | 6.2 | O=C(O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc(-c5ccccc5)cn4)cc3c2)cc1 | 10.1021/jm990387k | ||
| CHEMBL132341 | 29026 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 502 | 9 | 2 | 4 | 6.2 | O=C(O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc(-c5ccccc5)cn4)cc3c2)cc1 | 10.1021/jm990387k | ||
| 10031428 | 27446 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 595 | 10 | 2 | 6 | 5.2 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCc3ccccc3)cc12 | 10.1021/jm00055a011 | ||
| CHEMBL130873 | 27446 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 595 | 10 | 2 | 6 | 5.2 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCc3ccccc3)cc12 | 10.1021/jm00055a011 | ||
| 10371435 | 123704 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 603 | 13 | 1 | 6 | 6.2 | CCCCN(CCCC)C(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| CHEMBL338497 | 123704 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 603 | 13 | 1 | 6 | 6.2 | CCCCN(CCCC)C(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | ||
| 9932067 | 73568 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(COc2ccc(OCc3ccc4ccccc4n3)cc2)cc(Cc2nnn[nH]2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18597 | 73568 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(COc2ccc(OCc3ccc4ccccc4n3)cc2)cc(Cc2nnn[nH]2)c1 | 10.1021/jm00166a017 | ||
| 9827188 | 74241 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 497 | 10 | 1 | 9 | 4.3 | COC(=O)c1ccc(COc2cccc(OCc3ccc4ccccc4n3)c2)c(OCc2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18919 | 74241 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 497 | 10 | 1 | 9 | 4.3 | COC(=O)c1ccc(COc2cccc(OCc3ccc4ccccc4n3)c2)c(OCc2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| 10114090 | 74294 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(COc2ccc(OCc3ccc4ccccc4n3)cc2)cc(OCc2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18956 | 74294 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(COc2ccc(OCc3ccc4ccccc4n3)cc2)cc(OCc2nn[nH]n2)c1 | 10.1021/jm00166a017 | ||
| 44352103 | 123468 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | CC(NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccccc1CC(=O)O | 10.1021/jm990387k | ||
| CHEMBL337195 | 123468 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | CC(NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccccc1CC(=O)O | 10.1021/jm990387k | ||
| 10222948 | 72856 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 405 | 6 | 1 | 5 | 5.2 | C(=C/c1cccc(-c2nn[nH]n2)c1)\c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| CHEMBL18381 | 72856 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 405 | 6 | 1 | 5 | 5.2 | C(=C/c1cccc(-c2nn[nH]n2)c1)\c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | ||
| 15015282 | 74046 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc2nc(COc3ccc(OCc4ccc(Cc5nnn[nH]5)cc4)cc3)ccc2c1 | 10.1021/jm00166a017 | ||
| CHEMBL18816 | 74046 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc2nc(COc3ccc(OCc4ccc(Cc5nnn[nH]5)cc4)cc3)ccc2c1 | 10.1021/jm00166a017 | ||
| 14708751 | 194084 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 409 | 6 | 2 | 6 | 4.3 | COc1cc(C(=O)O)ccc1Cn1ncc2ccc(NC(=O)OC3CCCC3)cc21 | 10.1021/jm00168a037 | ||
| CHEMBL49298 | 194084 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 409 | 6 | 2 | 6 | 4.3 | COc1cc(C(=O)O)ccc1Cn1ncc2ccc(NC(=O)OC3CCCC3)cc21 | 10.1021/jm00168a037 | ||
| 14626842 | 108825 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 420 | 7 | 2 | 4 | 5.0 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| CHEMBL301928 | 108825 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 420 | 7 | 2 | 4 | 5.0 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | ||
| 105007 | 103875 | 32 | None | - | 1 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | ||
| CHEMBL267475 | 103875 | 32 | None | - | 1 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | ||
| CHEMBL267976 | 103875 | 32 | None | - | 1 | Guinea pig | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | ||
| 5059 | 213140 | 44 | None | - | 1 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/0960-894X(95)00226-J | ||
| CHEMBL8747 | 213140 | 44 | None | - | 1 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/0960-894X(95)00226-J | ||
| 5059 | 213140 | 44 | None | - | 1 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/0960-894X(95)00225-I | ||
| CHEMBL8747 | 213140 | 44 | None | - | 1 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/0960-894X(95)00225-I | ||
| 14650343 | 70881 | 1 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 333 | 6 | 1 | 6 | 2.9 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2nn[nH]n2)c1 | 10.1021/jm00166a016 | ||
| CHEMBL18081 | 70881 | 1 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 333 | 6 | 1 | 6 | 2.9 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2nn[nH]n2)c1 | 10.1021/jm00166a016 | ||
| 44352397 | 27968 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 504 | 7 | 2 | 8 | 4.0 | O=C(NCc1ccc(OCc2ccc3ccccc3n2)cc1)c1cccc2c(=O)cc(-c3nn[nH]n3)oc12 | 10.1021/jm990387k | ||
| CHEMBL131287 | 27968 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 504 | 7 | 2 | 8 | 4.0 | O=C(NCc1ccc(OCc2ccc3ccccc3n2)cc1)c1cccc2c(=O)cc(-c3nn[nH]n3)oc12 | 10.1021/jm990387k | ||
| 44286706 | 21388 | 0 | None | - | 1 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc(C(O)[C@@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00159a003 | ||
| CHEMBL1205015 | 21388 | 0 | None | - | 1 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc(C(O)[C@@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00159a003 | ||
| CHEMBL41301 | 21388 | 0 | None | - | 1 | Guinea pig | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc(C(O)[C@@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00159a003 | ||
| 44352159 | 26140 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 478 | 10 | 2 | 6 | 4.7 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)Nc1ccc(CCCc2nnn[nH]2)cc1 | 10.1021/jm990387k | ||
| CHEMBL129142 | 26140 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 478 | 10 | 2 | 6 | 4.7 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)Nc1ccc(CCCc2nnn[nH]2)cc1 | 10.1021/jm990387k | ||
| 448537 | 167029 | 89 | None | -41 | 25 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | nan | ||
| CHEMBL411 | 167029 | 89 | None | -41 | 25 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | nan | ||
| 44352186 | 28838 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 478 | 7 | 2 | 5 | 6.4 | O=C(Nc1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)OCc1ccc(C(=O)O)cc1 | 10.1021/jm990387k | ||
| CHEMBL132167 | 28838 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 478 | 7 | 2 | 5 | 6.4 | O=C(Nc1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)OCc1ccc(C(=O)O)cc1 | 10.1021/jm990387k | ||
| 44352154 | 171805 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1ccc(-c2nn[nH]n2)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| CHEMBL422609 | 171805 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1ccc(-c2nn[nH]n2)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | ||
| 10156907 | 74648 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 385 | 7 | 1 | 4 | 5.1 | O=C(O)c1ccc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc1 | 10.1021/jm00166a017 | ||
| CHEMBL19102 | 74648 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 385 | 7 | 1 | 4 | 5.1 | O=C(O)c1ccc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc1 | 10.1021/jm00166a017 | ||
| 105007 | 103875 | 32 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00166a016 | ||
| CHEMBL267475 | 103875 | 32 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00166a016 | ||
| CHEMBL267976 | 103875 | 32 | None | - | 1 | Guinea pig | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00166a016 | ||
| 10346 | 9337 | 46 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10391245 | ||
| 5281888 | 9337 | 46 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10391245 | ||
| CHEMBL15177 | 9337 | 46 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10391245 | ||
| 6193 | 10756 | 38 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 1666333 | ||
| 6509849 | 10756 | 38 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 1666333 | ||
| CHEMBL280481 | 10756 | 38 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 1666333 | ||
| 3353 | 9149 | 0 | None | 21 | 2 | Human | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 3353 | 9149 | 0 | None | 21 | 2 | Human | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 16306225 | ||
| 3412 | 9149 | 0 | None | 21 | 2 | Human | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 3412 | 9149 | 0 | None | 21 | 2 | Human | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 16306225 | ||
| 6435286 | 9149 | 0 | None | 21 | 2 | Human | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| 6435286 | 9149 | 0 | None | 21 | 2 | Human | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 16306225 | ||
| CHEMBL1521056 | 9149 | 0 | None | 21 | 2 | Human | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | ||
| CHEMBL1521056 | 9149 | 0 | None | 21 | 2 | Human | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 16306225 | ||
| 3353 | 9149 | 0 | None | 21 | 2 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | ||
| 3412 | 9149 | 0 | None | 21 | 2 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | ||
| 6435286 | 9149 | 0 | None | 21 | 2 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | ||
| CHEMBL1521056 | 9149 | 0 | None | 21 | 2 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | ||
| 3353 | 9149 | 0 | None | 21 | 2 | Human | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | None | ||
| 3412 | 9149 | 0 | None | 21 | 2 | Human | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | None | ||
| 6435286 | 9149 | 0 | None | 21 | 2 | Human | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | None | ||
| CHEMBL1521056 | 9149 | 0 | None | 21 | 2 | Human | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | None | ||
| 3353 | 9149 | 0 | None | 21 | 2 | Human | 9.6 | pKd | = | 9.6 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9504401 | ||
| 3353 | 9149 | 0 | None | 21 | 2 | Human | 9.6 | pKd | = | 9.6 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9547367 | ||
| 3412 | 9149 | 0 | None | 21 | 2 | Human | 9.6 | pKd | = | 9.6 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9504401 | ||
| 3412 | 9149 | 0 | None | 21 | 2 | Human | 9.6 | pKd | = | 9.6 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9547367 | ||
| 6435286 | 9149 | 0 | None | 21 | 2 | Human | 9.6 | pKd | = | 9.6 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9504401 | ||
| 6435286 | 9149 | 0 | None | 21 | 2 | Human | 9.6 | pKd | = | 9.6 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9547367 | ||
| CHEMBL1521056 | 9149 | 0 | None | 21 | 2 | Human | 9.6 | pKd | = | 9.6 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9504401 | ||
| CHEMBL1521056 | 9149 | 0 | None | 21 | 2 | Human | 9.6 | pKd | = | 9.6 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9547367 | ||
| 115219 | 8759 | 14 | None | 489 | 3 | Human | 10.6 | pKd | = | 10.6 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 1329767 | ||
| 3358 | 8759 | 14 | None | 489 | 3 | Human | 10.6 | pKd | = | 10.6 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 1329767 | ||
| 3414 | 8759 | 14 | None | 489 | 3 | Human | 10.6 | pKd | = | 10.6 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 1329767 | ||
| CHEMBL22033 | 8759 | 14 | None | 489 | 3 | Human | 10.6 | pKd | = | 10.6 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 1329767 | ||
| 2855 | 10904 | 104 | 3H-LTD4 | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| 3322 | 10904 | 104 | 3H-LTD4 | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| 5717 | 10904 | 104 | 3H-LTD4 | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| CHEMBL603 | 10904 | 104 | 3H-LTD4 | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| DB00549 | 10904 | 104 | 3H-LTD4 | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| None | 223000 | 0 | 3H-LTD4 | 95 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 514 | 11 | 1 | 5 | 6.5 | CN(C)C(=O)CCSC(C1=CC=CC(=C1)C=CC2=NC3=C(C=CC(=C3)Cl)C=C2)SCCC(=O)O | None | ||
| None | 222987 | 0 | 3H-LTD4 | 2187 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | PDSP KiDatabase | 473 | 7 | 2 | 3 | 7.9 | CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)S)O | None | ||
| 2812 | 11551 | 101 | None | 1 | 34 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | ||
| 2812 | 11551 | 101 | None | -58 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | ||
| CHEMBL104 | 11551 | 101 | None | 1 | 34 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | ||
| CHEMBL104 | 11551 | 101 | None | -58 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | ||
| 57340263 | 222999 | 0 | 3H-LTD4 | -1 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C/C=C/C=C/[C@H]([C@H](CCCC(=O)O)O)SC1=CC=C(C=C1)C(=O)O | None | ||
| 448537 | 167029 | 89 | None | 15 | 25 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | None | ||
| 448537 | 167029 | 89 | None | -41 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | None | ||
| CHEMBL411 | 167029 | 89 | None | 15 | 25 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | None | ||
| CHEMBL411 | 167029 | 89 | None | -41 | 25 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | None | ||
| 6436135 | 106348 | 43 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 9 | 2 | 4 | 5.8 | CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O | None | ||
| CHEMBL283754 | 106348 | 43 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 412 | 9 | 2 | 4 | 5.8 | CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O | None | ||
| 2237 | 9936 | 79 | None | 4 | 3 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| 3634 | 9936 | 79 | None | 4 | 3 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| 4887 | 9936 | 79 | None | 4 | 3 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| CHEMBL21333 | 9936 | 79 | None | 4 | 3 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| DB01411 | 9936 | 79 | None | 4 | 3 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
| 1836 | 9370 | 59 | None | 1 | 15 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| 3340 | 9370 | 59 | None | 1 | 15 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| 5281040 | 9370 | 59 | None | 1 | 15 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| CHEMBL787 | 9370 | 59 | None | 1 | 15 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| DB00471 | 9370 | 59 | None | 1 | 15 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| 1836 | 9370 | 59 | None | -1 | 15 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| 3340 | 9370 | 59 | None | -1 | 15 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| 5281040 | 9370 | 59 | None | -1 | 15 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| CHEMBL787 | 9370 | 59 | None | -1 | 15 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| DB00471 | 9370 | 59 | None | -1 | 15 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | ||
| 2855 | 10904 | 104 | None | 1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| 3322 | 10904 | 104 | None | 1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| 5717 | 10904 | 104 | None | 1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| CHEMBL603 | 10904 | 104 | None | 1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| DB00549 | 10904 | 104 | None | 1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| 2855 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| 3322 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| 5717 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| CHEMBL603 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| DB00549 | 10904 | 104 | None | -1 | 6 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
| 3352 | 9150 | 28 | None | -15 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 9547367 | ||
| 5280879 | 9150 | 28 | None | -15 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 9547367 | ||
| 5863 | 9150 | 28 | None | -15 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 9547367 | ||
| CHEMBL509456 | 9150 | 28 | None | -15 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 9547367 | ||
| 3354 | 9148 | 26 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 9547367 | ||
| 5280493 | 9148 | 26 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 9547367 | ||
| CHEMBL451509 | 9148 | 26 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 9547367 | ||
| DB08855 | 9148 | 26 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 9547367 | ||
| 5861 | 8846 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | Guide to Pharmacology | 710 | 16 | 3 | 8 | 8.9 | CCCc1c(OCCCC/C=C\C=C\[C@@H]([C@@H](c2cccc(c2)C(F)(F)F)O)Sc2ccc3c(c2)oc(cc3=O)C(=O)O)ccc(c1O)C(=O)C | 9504401 | ||
| 6913104 | 8846 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | Guide to Pharmacology | 710 | 16 | 3 | 8 | 8.9 | CCCc1c(OCCCC/C=C\C=C\[C@@H]([C@@H](c2cccc(c2)C(F)(F)F)O)Sc2ccc3c(c2)oc(cc3=O)C(=O)O)ccc(c1O)C(=O)C | 9504401 | ||
| CHEMBL1206833 | 8846 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | Guide to Pharmacology | 710 | 16 | 3 | 8 | 8.9 | CCCc1c(OCCCC/C=C\C=C\[C@@H]([C@@H](c2cccc(c2)C(F)(F)F)O)Sc2ccc3c(c2)oc(cc3=O)C(=O)O)ccc(c1O)C(=O)C | 9504401 | ||
| 3327 | 10477 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 472 | 17 | 3 | 6 | 5.7 | CCCCCCCCC/C=C\C=C\[C@H]([C@H](c1cccc(c1)c1nnn[nH]1)O)SCCC(=O)O | None | ||
| 6436123 | 10477 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 472 | 17 | 3 | 6 | 5.7 | CCCCCCCCC/C=C\C=C\[C@H]([C@H](c1cccc(c1)c1nnn[nH]1)O)SCCC(=O)O | None | ||
| CHEMBL278570 | 10477 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 472 | 17 | 3 | 6 | 5.7 | CCCCCCCCC/C=C\C=C\[C@H]([C@H](c1cccc(c1)c1nnn[nH]1)O)SCCC(=O)O | None | ||
| 128355 | 10441 | 30 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | None | ||
| 3329 | 10441 | 30 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | None | ||
| CHEMBL18132 | 10441 | 30 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | None | ||
| 115219 | 8759 | 14 | None | -489 | 3 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 2170649 | ||
| 3358 | 8759 | 14 | None | -489 | 3 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 2170649 | ||
| 3414 | 8759 | 14 | None | -489 | 3 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 2170649 | ||
| CHEMBL22033 | 8759 | 14 | None | -489 | 3 | Guinea pig | 9.7 | pKi | = | 9.7 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 2170649 | ||
| 3334 | 9921 | 9 | None | -5 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 9547367 | ||
| 60842 | 9921 | 9 | None | -5 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 9547367 | ||
| CHEMBL22776 | 9921 | 9 | None | -5 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 9547367 | ||
| 2237 | 9936 | 79 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 11996896 | ||
| 2237 | 9936 | 79 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 9504401 | ||
| 3634 | 9936 | 79 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 11996896 | ||
| 3634 | 9936 | 79 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 9504401 | ||
| 4887 | 9936 | 79 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 11996896 | ||
| 4887 | 9936 | 79 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 9504401 | ||
| CHEMBL21333 | 9936 | 79 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 11996896 | ||
| CHEMBL21333 | 9936 | 79 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 9504401 | ||
| DB01411 | 9936 | 79 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 11996896 | ||
| DB01411 | 9936 | 79 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 9504401 | ||
| 1836 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 11996896 | ||
| 3340 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 11996896 | ||
| 5281040 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 11996896 | ||
| CHEMBL787 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 11996896 | ||
| DB00471 | 9370 | 59 | None | -1 | 15 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 11996896 | ||
| 2855 | 10904 | 104 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 11996896 | ||
| 2855 | 10904 | 104 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 9504401 | ||
| 3322 | 10904 | 104 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 11996896 | ||
| 3322 | 10904 | 104 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 9504401 | ||
| 5717 | 10904 | 104 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 11996896 | ||
| 5717 | 10904 | 104 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 9504401 | ||
| CHEMBL603 | 10904 | 104 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 11996896 | ||
| CHEMBL603 | 10904 | 104 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 9504401 | ||
| DB00549 | 10904 | 104 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 11996896 | ||
| DB00549 | 10904 | 104 | None | 1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 9504401 | ||