GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	57781216	132625	0	None	8	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648356	132625	0	None	8	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	24954989	8314	1	None	25	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	7774	8314	1	None	25	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	CHEMBL1802025	8314	1	None	25	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	1357	9263	139	None	1	5	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	1672	9263	139	None	1	5	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	224	9263	139	None	1	5	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	896	9263	139	None	1	5	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	CHEMBL45	9263	139	None	1	5	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	DB01065	9263	139	None	1	5	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	1357	9263	139	None	1	5	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	1672	9263	139	None	1	5	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	224	9263	139	None	1	5	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	896	9263	139	None	1	5	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	CHEMBL45	9263	139	None	1	5	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	DB01065	9263	139	None	1	5	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	1357	9263	139	None	1	5	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	1672	9263	139	None	1	5	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	224	9263	139	None	1	5	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	896	9263	139	None	1	5	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	CHEMBL45	9263	139	None	1	5	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	DB01065	9263	139	None	1	5	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	139451757	191610	0	None	3	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4852096	191610	0	None	3	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451761	191376	0	None	4	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4848885	191376	0	None	4	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451781	191637	0	None	-2	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4852440	191637	0	None	-2	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	139451795	192108	0	None	2	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859677	192108	0	None	2	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451767	191783	0	None	5	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854625	191783	0	None	5	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	139451764	193046	0	None	-2	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4873903	193046	0	None	-2	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	145981769	173446	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	270	3	1	3	2.4	COc1ccc2ccc3c(c2n1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4281712	173446	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	270	3	1	3	2.4	COc1ccc2ccc3c(c2n1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	139451790	192075	18	None	6	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859295	192075	18	None	6	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	1357	9263	139	None	1	5	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	1672	9263	139	None	1	5	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	224	9263	139	None	1	5	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	896	9263	139	None	1	5	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	CHEMBL45	9263	139	None	1	5	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	DB01065	9263	139	None	1	5	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	1357	9263	139	None	1	5	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1672	9263	139	None	1	5	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	224	9263	139	None	1	5	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	896	9263	139	None	1	5	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	CHEMBL45	9263	139	None	1	5	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	DB01065	9263	139	None	1	5	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1357	9263	139	None	1	5	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	1672	9263	139	None	1	5	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	224	9263	139	None	1	5	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	896	9263	139	None	1	5	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	CHEMBL45	9263	139	None	1	5	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	DB01065	9263	139	None	1	5	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	139451757	191610	0	None	3	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4852096	191610	0	None	3	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451763	193112	0	None	-1	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	305	8	1	5	2.4	CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21	10.1021/acs.jmedchem.0c00627
	CHEMBL4874954	193112	0	None	-1	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	305	8	1	5	2.4	CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21	10.1021/acs.jmedchem.0c00627
	9839629	106892	0	None	-1	2	Human	9.8	pEC50	=	9.8	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL287560	106892	0	None	-1	2	Human	9.8	pEC50	=	9.8	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	139451761	191376	0	None	4	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4848885	191376	0	None	4	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	198	7101	126	None	-3	4	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	82148	7101	126	None	-3	4	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	99	7101	126	None	-3	4	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	CHEMBL10878	7101	126	None	-3	4	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	DB06594	7101	126	None	-3	4	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	145982070	173254	0	None	1	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	283	3	1	2	3.2	COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4278248	173254	0	None	1	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	283	3	1	2	3.2	COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	145993214	173530	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	285	3	2	3	2.2	CNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4283539	173530	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	285	3	2	3	2.2	CNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	139451767	191783	0	None	5	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854625	191783	0	None	5	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	139451776	191790	0	None	3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854836	191790	0	None	3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	139451799	192618	0	None	3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	279	5	1	5	1.9	COc1ccc2nc(SC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4867553	192618	0	None	3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	279	5	1	5	1.9	COc1ccc2nc(SC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	139451790	192075	18	None	6	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859295	192075	18	None	6	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	164946945	197008	1	None	-3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5174929	197008	1	None	-3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	139451781	191637	0	None	-2	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4852440	191637	0	None	-2	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	139451795	192108	0	None	2	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859677	192108	0	None	2	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451764	193046	0	None	-2	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4873903	193046	0	None	-2	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	168296374	199297	0	None	9	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	CHEMBL5209359	199297	0	None	9	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	53237951	68793	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	333	5	1	2	3.7	CC(=O)NCCC1=C(Cc2ccccc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774518	68793	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	333	5	1	2	3.7	CC(=O)NCCC1=C(Cc2ccccc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	168296374	199297	0	None	9	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	CHEMBL5209359	199297	0	None	9	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	44394435	73701	0	None	34	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity towards human Melatonin receptor type 1A was determined by its ability to inhibit forskolin stimulated cAMP accumulationAgonist activity towards human Melatonin receptor type 1A was determined by its ability to inhibit forskolin stimulated cAMP accumulation	ChEMBL	361	8	1	2	5.2	CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL186586	73701	0	None	34	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity towards human Melatonin receptor type 1A was determined by its ability to inhibit forskolin stimulated cAMP accumulationAgonist activity towards human Melatonin receptor type 1A was determined by its ability to inhibit forskolin stimulated cAMP accumulation	ChEMBL	361	8	1	2	5.2	CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	168274836	196926	0	None	17	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5173623	196926	0	None	17	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	139451780	192723	0	None	-1	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	303	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1	10.1021/acs.jmedchem.0c00627
	CHEMBL4869463	192723	0	None	-1	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	303	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1	10.1021/acs.jmedchem.0c00627
	137660333	166299	0	None	-3	2	Human	9.1	pEC50	=	9.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	244	4	1	3	1.9	COc1ccc2cccc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4102177	166299	0	None	-3	2	Human	9.1	pEC50	=	9.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	244	4	1	3	1.9	COc1ccc2cccc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.12.013
	145979585	173269	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	313	5	2	3	3.0	CCCNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4278446	173269	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	313	5	2	3	3.0	CCCNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	145986532	174060	0	None	-4	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	2	3.0	COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4293386	174060	0	None	-4	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	2	3.0	COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	122188347	129941	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	232	3	1	2	2.0	CCC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612604	129941	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	232	3	1	2	2.0	CCC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	139451766	191226	0	None	-4	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4846505	191226	0	None	-4	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451769	192921	0	None	-5	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC	10.1021/acs.jmedchem.0c00627
	CHEMBL4872217	192921	0	None	-5	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC	10.1021/acs.jmedchem.0c00627
	1357	9263	139	None	1	5	Human	9.0	pEC50	=	9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	1672	9263	139	None	1	5	Human	9.0	pEC50	=	9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	224	9263	139	None	1	5	Human	9.0	pEC50	=	9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	896	9263	139	None	1	5	Human	9.0	pEC50	=	9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	CHEMBL45	9263	139	None	1	5	Human	9.0	pEC50	=	9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	DB01065	9263	139	None	1	5	Human	9.0	pEC50	=	9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	127026427	144462	0	None	-1	2	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758679	144462	0	None	-1	2	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	127026425	144598	0	None	8	2	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759816	144598	0	None	8	2	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	168274836	196926	0	None	17	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5173623	196926	0	None	17	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	198	7101	126	None	-3	4	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	82148	7101	126	None	-3	4	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	99	7101	126	None	-3	4	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	CHEMBL10878	7101	126	None	-3	4	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	DB06594	7101	126	None	-3	4	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	198	7101	126	None	-3	4	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	198	7101	126	None	-3	4	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	82148	7101	126	None	-3	4	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	82148	7101	126	None	-3	4	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	99	7101	126	None	-3	4	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	99	7101	126	None	-3	4	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	CHEMBL10878	7101	126	None	-3	4	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	CHEMBL10878	7101	126	None	-3	4	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	DB06594	7101	126	None	-3	4	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	DB06594	7101	126	None	-3	4	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	1357	9263	139	None	1	5	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	1672	9263	139	None	1	5	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	224	9263	139	None	1	5	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	896	9263	139	None	1	5	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	CHEMBL45	9263	139	None	1	5	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	DB01065	9263	139	None	1	5	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	198	7101	126	None	-3	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	82148	7101	126	None	-3	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	99	7101	126	None	-3	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	CHEMBL10878	7101	126	None	-3	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	DB06594	7101	126	None	-3	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	198	7101	126	None	-3	4	Human	8.8	pEC50	=	8.8	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	82148	7101	126	None	-3	4	Human	8.8	pEC50	=	8.8	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	99	7101	126	None	-3	4	Human	8.8	pEC50	=	8.8	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	CHEMBL10878	7101	126	None	-3	4	Human	8.8	pEC50	=	8.8	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	DB06594	7101	126	None	-3	4	Human	8.8	pEC50	=	8.8	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	198	7101	126	None	-3	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	82148	7101	126	None	-3	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	99	7101	126	None	-3	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	CHEMBL10878	7101	126	None	-3	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	DB06594	7101	126	None	-3	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	122188346	129940	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	262	4	1	3	2.0	CCC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612603	129940	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	262	4	1	3	2.0	CCC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	139451776	191790	0	None	3	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854836	191790	0	None	3	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	1357	9263	139	None	1	5	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	1672	9263	139	None	1	5	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	224	9263	139	None	1	5	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	896	9263	139	None	1	5	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	CHEMBL45	9263	139	None	1	5	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	DB01065	9263	139	None	1	5	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	18360658	15662	0	None	10	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	518	13	2	5	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097497	15662	0	None	10	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	518	13	2	5	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	145979282	173454	0	None	-1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4281915	173454	0	None	-1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145986700	173998	0	None	-5	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	328	4	2	2	3.5	CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4292109	173998	0	None	-5	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	328	4	2	2	3.5	CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	122220128	166454	0	None	-27	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	309	6	2	3	2.3	COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1	10.1039/C4MD00149D
	CHEMBL4104020	166454	0	None	-27	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	309	6	2	3	2.3	COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1	10.1039/C4MD00149D
	145992795	173570	0	None	-25	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	342	5	2	2	3.9	CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4284223	173570	0	None	-25	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	342	5	2	2	3.9	CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145991111	173691	0	None	-10	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	319	5	1	3	2.8	CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4286494	173691	0	None	-10	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	319	5	1	3	2.8	CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	23658143	163156	1	None	-41	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4066279	163156	1	None	-41	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	46888492	15615	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	564	14	2	5	6.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)c5ccco5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1096991	15615	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	564	14	2	5	6.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)c5ccco5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	122188231	129926	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	247	3	2	2	1.8	CCNC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612462	129926	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	247	3	2	2	1.8	CCNC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	19703063	35688	1	None	1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.bmcl.2011.02.097
	CHEMBL137969	35688	1	None	1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.bmcl.2011.02.097
	46888520	15415	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	538	15	2	4	6.1	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095195	15415	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	538	15	2	4	6.1	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	21581654	67526	1	None	-10	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760944	67526	1	None	-10	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	10385056	119013	0	None	-354	2	Human	6.9	pEC50	=	6.9	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL329086	119013	0	None	-354	2	Human	6.9	pEC50	=	6.9	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	164946945	197008	1	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5174929	197008	1	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	145986330	173836	0	None	-3	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	286	3	2	2	2.7	COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4289115	173836	0	None	-3	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	286	3	2	2	2.7	COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3	10.1016/j.ejmech.2017.10.025
	52918080	67538	0	None	-12	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	287	4	1	4	2.1	COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3	10.1016/j.bmcl.2011.02.097
	CHEMBL1760957	67538	0	None	-12	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	287	4	1	4	2.1	COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3	10.1016/j.bmcl.2011.02.097
	9937825	15640	0	None	2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	564	17	2	4	6.7	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097315	15640	0	None	2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	564	17	2	4	6.7	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12	10.1016/j.bmc.2010.04.008
	71508233	93849	0	None	-676	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	355	10	1	3	3.9	CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326201	93849	0	None	-676	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	355	10	1	3	3.9	CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	122188230	129925	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	277	4	2	3	1.8	CCNC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612461	129925	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	277	4	2	3	1.8	CCNC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	137639112	163631	0	None	-8128	2	Human	5.8	pEC50	=	5.8	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	245	4	2	3	1.5	COc1ccc2cccc(CCNC(N)=O)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4071572	163631	0	None	-8128	2	Human	5.8	pEC50	=	5.8	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	245	4	2	3	1.5	COc1ccc2cccc(CCNC(N)=O)c2n1	10.1016/j.ejmech.2016.12.013
	4018512	49994	42	None	-2	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	308	5	2	2	3.5	COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1039/d2md00156j
	CHEMBL15060	49994	42	None	-2	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	308	5	2	2	3.5	COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1039/d2md00156j
	121231413	10681	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	10.1021/acs.jmedchem.5b01066
	9226	10681	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	10.1021/acs.jmedchem.5b01066
	CHEMBL3612464	10681	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	10.1021/acs.jmedchem.5b01066
	52953165	69182	0	None	-87	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	389	7	1	3	5.6	C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779810	69182	0	None	-87	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	389	7	1	3	5.6	C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	137647756	164723	0	None	-213	2	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	259	4	2	3	1.7	CNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4084612	164723	0	None	-213	2	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	259	4	2	3	1.7	CNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	23658146	163897	1	None	-15	2	Human	7.7	pEC50	=	7.7	Functional	Partial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4074895	163897	1	None	-15	2	Human	7.7	pEC50	=	7.7	Functional	Partial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	122188237	129932	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.1	CC(=O)NC[C@H]1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612469	129932	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.1	CC(=O)NC[C@H]1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	145981162	173276	0	None	-2	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	270	3	2	2	2.5	COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4278575	173276	0	None	-2	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	270	3	2	2	2.5	COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3	10.1016/j.ejmech.2017.10.025
	122188349	129943	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	246	4	1	2	2.4	CCCN1c2ccccc2CCC1CNC(C)=O	10.1021/acs.jmedchem.5b01066
	CHEMBL3612606	129943	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	246	4	1	2	2.4	CCCN1c2ccccc2CCC1CNC(C)=O	10.1021/acs.jmedchem.5b01066
	52918079	67529	0	None	-2	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	261	6	1	4	2.0	CCCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	CHEMBL1760947	67529	0	None	-2	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	261	6	1	4	2.0	CCCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	139451766	191226	0	None	-4	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4846505	191226	0	None	-4	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	1357	9263	139	None	1	5	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	1672	9263	139	None	1	5	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	224	9263	139	None	1	5	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	896	9263	139	None	1	5	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	CHEMBL45	9263	139	None	1	5	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	DB01065	9263	139	None	1	5	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	1357	9263	139	None	1	5	Human	8.7	pEC50	=	8.7	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	1672	9263	139	None	1	5	Human	8.7	pEC50	=	8.7	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	224	9263	139	None	1	5	Human	8.7	pEC50	=	8.7	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	896	9263	139	None	1	5	Human	8.7	pEC50	=	8.7	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	CHEMBL45	9263	139	None	1	5	Human	8.7	pEC50	=	8.7	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	DB01065	9263	139	None	1	5	Human	8.7	pEC50	=	8.7	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	10163052	15293	0	None	10	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	483	12	2	4	5.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1094212	15293	0	None	10	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	483	12	2	4	5.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12	10.1016/j.bmc.2010.04.008
	46888491	15443	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	501	13	3	4	4.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4[nH]cc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095522	15443	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	501	13	3	4	4.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4[nH]cc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	9870683	15661	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	502	13	2	5	5.2	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4occ(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097496	15661	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	502	13	2	5	5.2	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4occ(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	46888521	15416	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	499	12	1	5	5.6	COC(=O)Cc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095196	15416	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	499	12	1	5	5.6	COC(=O)Cc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	71508235	93850	0	None	-14	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	327	8	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326203	93850	0	None	-14	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	327	8	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	145990308	173811	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	328	5	2	2	3.8	CCCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4288690	173811	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	328	5	2	2	3.8	CCCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145987794	173899	0	None	-6	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	298	4	2	2	3.2	CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4290302	173899	0	None	-6	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	298	4	2	2	3.2	CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137637884	163025	0	None	-19	2	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	280	3	1	2	3.3	CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4064813	163025	0	None	-19	2	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	280	3	1	2	3.3	CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	53231366	69175	0	None	-309	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	363	5	1	3	5.0	CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779804	69175	0	None	-309	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	363	5	1	3	5.0	CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	86273228	128098	0	None	-18	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	258	6	2	2	2.4	C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580910	128098	0	None	-18	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	258	6	2	2	2.4	C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	9927219	119099	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL329263	119099	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	46888522	15417	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	513	12	1	5	6.2	COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1	10.1016/j.bmc.2010.04.008
	CHEMBL1095197	15417	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	513	12	1	5	6.2	COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1	10.1016/j.bmc.2010.04.008
	168283863	197749	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	274	3	0	4	2.5	COc1cc2c(CN3CCN(C)CC3)coc2cc1C	10.1039/d2md00156j
	CHEMBL5186032	197749	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	274	3	0	4	2.5	COc1cc2c(CN3CCN(C)CC3)coc2cc1C	10.1039/d2md00156j
	46845151	15438	0	None	7	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	499	12	2	4	6.1	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095505	15438	0	None	7	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	499	12	2	4	6.1	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12	10.1016/j.bmc.2010.04.008
	53231465	69174	0	None	-35	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	237	3	1	2	2.7	CC(=O)NCCc1csc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779803	69174	0	None	-35	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	237	3	1	2	2.7	CC(=O)NCCc1csc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	122188225	129921	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	218	3	2	2	1.9	CCC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612456	129921	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	218	3	2	2	1.9	CCC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	122188227	129923	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	233	3	3	2	1.7	CCNC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612458	129923	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	233	3	3	2	1.7	CCNC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	10926138	214756	0	None	-147	2	Human	7.6	pEC50	=	7.6	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	349	8	1	3	4.3	C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL97186	214756	0	None	-147	2	Human	7.6	pEC50	=	7.6	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	349	8	1	3	4.3	C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	23642307	165674	1	None	-39	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4095334	165674	1	None	-39	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	145	6928	49	None	-144	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1832	6928	49	None	-144	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	CHEMBL7257	6928	49	None	-144	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	DB14010	6928	49	None	-144	11	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	9064	111996	94	None	-1	4	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate ReaderAgonist activity at human MT1R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate Reader	ChEMBL	290	1	5	6	1.5	Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2	10.1016/j.ejmech.2020.112960
	CHEMBL311498	111996	94	None	-1	4	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate ReaderAgonist activity at human MT1R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate Reader	ChEMBL	290	1	5	6	1.5	Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2	10.1016/j.ejmech.2020.112960
	7778	7601	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
	9957516	7601	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
	CHEMBL1094546	7601	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
	86079062	187511	0	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2ncnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4755860	187511	0	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2ncnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	198	7101	126	None	-3	4	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	82148	7101	126	None	-3	4	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	99	7101	126	None	-3	4	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	CHEMBL10878	7101	126	None	-3	4	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	DB06594	7101	126	None	-3	4	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	122188229	129924	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	249	3	3	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612460	129924	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	249	3	3	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	86273227	128095	0	None	-3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	242	4	2	2	1.5	C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580907	128095	0	None	-3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	242	4	2	2	1.5	C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	127025783	144516	0	None	-8	2	Human	7.5	pEC50	=	7.5	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759160	144516	0	None	-8	2	Human	7.5	pEC50	=	7.5	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1	10.1016/j.ejmech.2015.12.047
	145982333	173336	0	None	-2	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4279639	173336	0	None	-2	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	53238410	68802	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	361	5	1	2	4.7	CC(=O)NCCC1=C(c2cccc(C(C)C)c2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774529	68802	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	361	5	1	2	4.7	CC(=O)NCCC1=C(c2cccc(C(C)C)c2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	18007928	15437	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	485	12	2	4	5.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CC(=O)O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095504	15437	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	485	12	2	4	5.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CC(=O)O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	139451784	192174	0	None	-1	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	317	7	1	5	2.4	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1	10.1021/acs.jmedchem.0c00627
	CHEMBL4860729	192174	0	None	-1	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	317	7	1	5	2.4	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1	10.1021/acs.jmedchem.0c00627
	145993566	174150	0	None	-1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	5	2	2	3.6	CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4294790	174150	0	None	-1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	5	2	2	3.6	CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137650826	164284	0	None	-28	2	Human	7.5	pEC50	=	7.5	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4079699	164284	0	None	-28	2	Human	7.5	pEC50	=	7.5	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	122188236	129931	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.1	CC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612468	129931	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.1	CC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	54581170	67537	0	None	-2	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	359	4	1	4	1.8	COc1ccc2c(I)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760956	67537	0	None	-2	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	359	4	1	4	1.8	COc1ccc2c(I)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	162649247	186854	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	351	6	1	5	3.0	COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1	10.1016/j.ejmech.2020.112078
	CHEMBL4747996	186854	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	351	6	1	5	3.0	COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1	10.1016/j.ejmech.2020.112078
	122178509	128106	0	None	-9	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580919	128106	0	None	-9	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	122188235	129930	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	308	5	1	2	3.5	CCC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612467	129930	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	308	5	1	2	3.5	CCC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	1353	10208	5	None	-51	2	Human	7.4	pEC50	=	7.4	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	9998187	10208	5	None	-51	2	Human	7.4	pEC50	=	7.4	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	CHEMBL33549	10208	5	None	-51	2	Human	7.4	pEC50	=	7.4	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	86273226	128096	0	None	-12	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	256	5	2	2	1.9	C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580908	128096	0	None	-12	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	256	5	2	2	1.9	C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	23658145	164242	1	None	-52	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4079214	164242	1	None	-52	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	122188232	129927	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	353	6	2	3	3.3	CCNC(=O)NCC1CCc2c(OC)cccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612463	129927	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	353	6	2	3	3.3	CCNC(=O)NCC1CCc2c(OC)cccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	145982167	173390	0	None	-3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	305	4	1	3	2.4	COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4280601	173390	0	None	-3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	305	4	1	3	2.4	COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	52918077	67527	2	None	-1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760945	67527	2	None	-1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	53238181	7721	0	None	-3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	7780	7721	0	None	-3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	CHEMBL1774519	7721	0	None	-3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	127026423	144597	0	None	-6	2	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759802	144597	0	None	-6	2	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	127029516	144412	0	None	-3	2	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3occ(CNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758225	144412	0	None	-3	2	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3occ(CNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	71508234	7492	0	None	-173	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	7924	7492	0	None	-173	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	CHEMBL2326202	7492	0	None	-173	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	162668689	189537	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	285	5	1	4	2.2	COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4790145	189537	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	285	5	1	4	2.2	COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	162656758	187701	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4757920	187701	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	10301190	15337	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	511	12	1	5	6.2	COC(=O)c1ccc(-c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc2)cc1	10.1016/j.bmc.2010.04.008
	CHEMBL1094545	15337	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	511	12	1	5	6.2	COC(=O)c1ccc(-c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc2)cc1	10.1016/j.bmc.2010.04.008
	23642306	165852	1	None	-17	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4097233	165852	1	None	-17	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	10925526	119111	0	None	-47	2	Human	6.3	pEC50	=	6.3	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	329	6	1	3	4.2	COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL329299	119111	0	None	-47	2	Human	6.3	pEC50	=	6.3	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	329	6	1	3	4.2	COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	145982333	173336	0	None	-2	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4279639	173336	0	None	-2	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145990662	173708	0	None	-16	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	4	2	2	3.4	CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4286896	173708	0	None	-16	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	4	2	2	3.4	CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145988741	174015	0	None	-12	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	299	5	1	3	2.6	COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4292336	174015	0	None	-12	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	299	5	1	3	2.6	COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	52918078	67528	0	None	-3	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	247	5	1	4	1.6	CCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	CHEMBL1760946	67528	0	None	-3	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	247	5	1	4	1.6	CCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	127026426	144578	0	None	-1	2	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759606	144578	0	None	-1	2	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	86273229	128097	1	None	-3	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	244	5	2	2	2.0	C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580909	128097	1	None	-3	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	244	5	2	2	2.0	C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	145979689	173402	0	None	-1	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	314	3	2	2	3.1	CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4280791	173402	0	None	-1	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	314	3	2	2	3.1	CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	122188351	129944	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.7	CCC(=O)NCC1CCc2ccccc2N1c1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612608	129944	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.7	CCC(=O)NCC1CCc2ccccc2N1c1ccccc1	10.1021/acs.jmedchem.5b01066
	137650611	164291	0	None	-91	2	Human	7.2	pEC50	=	7.2	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	244	4	1	3	1.9	CNC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4079784	164291	0	None	-91	2	Human	7.2	pEC50	=	7.2	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	244	4	1	3	1.9	CNC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	162649850	186917	0	None	-2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4748822	186917	0	None	-2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	127026062	144467	0	None	-7	2	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758717	144467	0	None	-7	2	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	18360631	15487	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	516	13	2	4	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4c(c3)C(CCNC(C)=O)CCC4)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095831	15487	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	516	13	2	4	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4c(c3)C(CCNC(C)=O)CCC4)cc12	10.1016/j.bmc.2010.04.008
	145983175	173210	0	None	-1	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	314	4	2	2	3.4	CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4277390	173210	0	None	-1	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	314	4	2	2	3.4	CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	86273222	128101	0	None	-2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580913	128101	0	None	-2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1	10.1021/acs.jmedchem.5b00245
	44359437	36673	0	None	3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1039/C4MD00149D
	CHEMBL138807	36673	0	None	3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1039/C4MD00149D
	1355	10211	5	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	9806449	10211	5	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	CHEMBL14453	10211	5	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	127025786	144627	0	None	-12	2	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12	10.1016/j.ejmech.2015.12.047
	CHEMBL3760044	144627	0	None	-12	2	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12	10.1016/j.ejmech.2015.12.047
	23658144	164958	1	None	-100	2	Human	7.1	pEC50	=	7.1	Functional	Partial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4087633	164958	1	None	-100	2	Human	7.1	pEC50	=	7.1	Functional	Partial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	145979282	173454	0	None	-1	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4281915	173454	0	None	-1	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	127025782	144509	0	None	1	2	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	297	4	1	3	3.9	COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759054	144509	0	None	1	2	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	297	4	1	3	3.9	COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1	10.1016/j.ejmech.2015.12.047
	71508232	93848	0	None	-75	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	351	7	1	3	3.6	CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326200	93848	0	None	-75	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	351	7	1	3	3.6	CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	122188352	129945	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	263	3	2	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612609	129945	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	263	3	2	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	145988269	173969	0	None	-12	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	326	5	2	2	3.8	CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4291381	173969	0	None	-12	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	326	5	2	2	3.8	CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	46865422	93846	0	None	-181	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326199	93846	0	None	-181	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	18007985	15488	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	538	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095832	15488	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	538	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	127025784	144511	0	None	-8	2	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759084	144511	0	None	-8	2	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1	10.1016/j.ejmech.2015.12.047
	137636213	162865	0	None	-47	2	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4062947	162865	0	None	-47	2	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	137655238	165664	0	None	-891	2	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	275	4	2	3	1.9	CNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4095210	165664	0	None	-891	2	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	275	4	2	3	1.9	CNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	122188224	129920	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	248	4	2	3	1.9	CCC(=O)NCC1CCc2c(cccc2OC)N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612455	129920	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	248	4	2	3	1.9	CCC(=O)NCC1CCc2c(cccc2OC)N1	10.1021/acs.jmedchem.5b01066
	3525815	80921	3	None	-4	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at MT1Agonist activity at MT1	ChEMBL	271	2	0	3	4.1	c1ccc(-n2cc(-c3ccnc4ccccc34)cn2)cc1	10.1016/j.bmcl.2012.03.032
	CHEMBL2022867	80921	3	None	-4	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at MT1Agonist activity at MT1	ChEMBL	271	2	0	3	4.1	c1ccc(-n2cc(-c3ccnc4ccccc34)cn2)cc1	10.1016/j.bmcl.2012.03.032
	54582195	67536	0	None	-9	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	329	5	1	5	1.9	COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760955	67536	0	None	-9	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	329	5	1	5	1.9	COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	81689735	128103	0	None	1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	257	4	1	4	2.7	COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580916	128103	0	None	1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	257	4	1	4	2.7	COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	86273223	128099	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	242	3	1	3	3.1	COc1ccc2[nH]cc(Cc3ncc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580911	128099	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	242	3	1	3	3.1	COc1ccc2[nH]cc(Cc3ncc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	44241665	202479	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	329	6	1	4	2.6	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
	CHEMBL556908	202479	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	329	6	1	4	2.6	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
	90655902	117644	0	None	-	0	Human	9.7	pKi	=	9.7	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	330	5	2	4	2.5	CCOC(=O)c1[nH]c2ccc(OC)c3c2c1[C@@H](CNC(C)=O)CC3	10.1021/jm401343c
	CHEMBL3260982	117644	0	None	-	0	Human	9.7	pKi	=	9.7	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	330	5	2	4	2.5	CCOC(=O)c1[nH]c2ccc(OC)c3c2c1[C@@H](CNC(C)=O)CC3	10.1021/jm401343c
	24763223	7004	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1021/jm401343c
	8289	7004	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1021/jm401343c
	CHEMBL3260987	7004	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1021/jm401343c
	52918077	67527	2	None	-1	2	Human	8.9	pKi	=	8.9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assay	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1021/jm401343c
	CHEMBL1760945	67527	2	None	-1	2	Human	8.9	pKi	=	8.9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assay	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1021/jm401343c
	11185529	10686	5	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assayAntagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assay	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm401343c
	7772	10686	5	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assayAntagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assay	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm401343c
	CHEMBL189449	10686	5	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assayAntagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assay	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm401343c
	1357	9263	139	None	1	5	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	None	1	5	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	None	1	5	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	None	1	5	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	None	1	5	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	None	1	5	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	103828029	10691	0	None	-20	2	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	292	4	1	3	3.5	COc1ccc(c(c1)CNc1cccnc1)Br	32040955
	10667	10691	0	None	-20	2	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	292	4	1	3	3.5	COc1ccc(c(c1)CNc1cccnc1)Br	32040955
	10666	10692	0	None	21	2	Human	7.3	pEC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	4	2	3	4.5	Clc1ccc(c(c1)Br)CNc1cccc(c1)c1nnc[nH]1	32040955
	138993662	10692	0	None	21	2	Human	7.3	pEC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	4	2	3	4.5	Clc1ccc(c(c1)Br)CNc1cccc(c1)c1nnc[nH]1	32040955
	10665	10690	0	None	50	2	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	3	4.2	CC(c1ccc(cc1)CNc1cccc(c1)c1[nH]cnn1)C	32040955
	137977202	10690	0	None	50	2	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	3	4.2	CC(c1ccc(cc1)CNc1cccc(c1)c1[nH]cnn1)C	32040955
	23581869	7342	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	354	5	2	5	3.2	CCCNC(=O)c1nnc2c(c1N)cccc2c1c(F)cccc1OC	None
	7712	7342	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	354	5	2	5	3.2	CCCNC(=O)c1nnc2c(c1N)cccc2c1c(F)cccc1OC	None
	CHEMBL1783282	7342	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	354	5	2	5	3.2	CCCNC(=O)c1nnc2c(c1N)cccc2c1c(F)cccc1OC	None
	DB13994	7342	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	354	5	2	5	3.2	CCCNC(=O)c1nnc2c(c1N)cccc2c1c(F)cccc1OC	None

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	10440	9458	20	None	-21	3	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	139030523	9458	20	None	-21	3	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	CHEMBL4449712	9458	20	None	-21	3	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	122178509	128106	0	None	-8	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human recombinant melatonin receptor-1 expressed in CHO cells assessed as effect on impedance by cellular dielectric spectroscopyAgonist activity at human recombinant melatonin receptor-1 expressed in CHO cells assessed as effect on impedance by cellular dielectric spectroscopy	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580919	128106	0	None	-8	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human recombinant melatonin receptor-1 expressed in CHO cells assessed as effect on impedance by cellular dielectric spectroscopyAgonist activity at human recombinant melatonin receptor-1 expressed in CHO cells assessed as effect on impedance by cellular dielectric spectroscopy	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	19703003	37739	0	None	-	0	Human	10.9	pIC50	=	10.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	309	5	2	3	2.9	COc1c[nH]c2nc(-c3ccccc3)c(CCNC(C)=O)c-2c1	10.1021/jm980026p
	CHEMBL139855	37739	0	None	-	0	Human	10.9	pIC50	=	10.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	309	5	2	3	2.9	COc1c[nH]c2nc(-c3ccccc3)c(CCNC(C)=O)c-2c1	10.1021/jm980026p
	9927219	119099	0	None	-25	2	Human	10.8	pIC50	=	10.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL329263	119099	0	None	-25	2	Human	10.8	pIC50	=	10.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm980026p
	57781211	132630	0	None	-	0	Human	10.7	pIC50	=	10.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	376	8	1	3	4.9	CC(=O)NCCC1CCc2ccc3nc(CCCCc4ccccc4)oc3c21	nan
	CHEMBL3648361	132630	0	None	-	0	Human	10.7	pIC50	=	10.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	376	8	1	3	4.9	CC(=O)NCCC1CCc2ccc3nc(CCCCc4ccccc4)oc3c21	nan
	23634404	132628	0	None	-	0	Human	10.5	pIC50	=	10.5	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648359	132628	0	None	-	0	Human	10.5	pIC50	=	10.5	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	nan
	23725569	132632	0	None	-	0	Human	10.4	pIC50	=	10.4	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)sc3c21	nan
	CHEMBL3648363	132632	0	None	-	0	Human	10.4	pIC50	=	10.4	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)sc3c21	nan
	57781216	132625	0	None	2	2	Human	10.2	pIC50	=	10.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648356	132625	0	None	2	2	Human	10.2	pIC50	=	10.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	nan
	23725512	132622	0	None	-	0	Human	10.2	pIC50	=	10.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	256	3	1	3	2.6	CC(=O)NCCC1=CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648350	132622	0	None	-	0	Human	10.2	pIC50	=	10.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	256	3	1	3	2.6	CC(=O)NCCC1=CCc2ccc3nc(C)oc3c21	nan
	57781262	167615	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	374	7	1	3	4.9	CC(=O)NC/C=C1\CCc2ccc3nc(CCCCc4ccccc4)oc3c21	nan
	CHEMBL4114715	167615	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	374	7	1	3	4.9	CC(=O)NC/C=C1\CCc2ccc3nc(CCCCc4ccccc4)oc3c21	nan
	57781258	132638	0	None	-	0	Human	10.0	pIC50	=	10.0	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	312	3	1	3	3.2	Cc1nc2ccc3c(c2o1)C(CCNC(=O)C(F)(F)F)CC3	nan
	CHEMBL3648369	132638	0	None	-	0	Human	10.0	pIC50	=	10.0	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	312	3	1	3	3.2	Cc1nc2ccc3c(c2o1)C(CCNC(=O)C(F)(F)F)CC3	nan
	1357	9263	139	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.03.006
	1672	9263	139	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.03.006
	224	9263	139	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.03.006
	896	9263	139	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.03.006
	CHEMBL45	9263	139	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.03.006
	DB01065	9263	139	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.03.006
	1357	9263	139	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.11.014
	1672	9263	139	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.11.014
	224	9263	139	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.11.014
	896	9263	139	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.11.014
	CHEMBL45	9263	139	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.11.014
	DB01065	9263	139	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.11.014
	23725514	132627	0	None	1	2	Human	9.9	pIC50	=	9.9	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648358	132627	0	None	1	2	Human	9.9	pIC50	=	9.9	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21	nan
	23725565	132624	0	None	1	2	Human	9.8	pIC50	=	9.8	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCCC1CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648355	132624	0	None	1	2	Human	9.8	pIC50	=	9.8	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCCC1CCc2ccc3nc(C)oc3c21	nan
	23725567	132631	0	None	2	2	Human	9.8	pIC50	=	9.8	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCCC1CCc2ccc3nc(C)sc3c21	nan
	CHEMBL3648362	132631	0	None	2	2	Human	9.8	pIC50	=	9.8	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCCC1CCc2ccc3nc(C)sc3c21	nan
	15340632	16546	1	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	267	3	1	2	2.9	CC(=O)NCCc1cccc2ccc3c(c12)C=CCO3	10.1021/jm980026p
	CHEMBL11356	16546	1	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	267	3	1	2	2.9	CC(=O)NCCc1cccc2ccc3c(c12)C=CCO3	10.1021/jm980026p
	72548703	168346	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [125I]NDP-alpha -MSH from human recombinant MT1 receptor after 240 mins by scintillation counting analysisDisplacement of [125I]NDP-alpha -MSH from human recombinant MT1 receptor after 240 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	CHEMBL4128926	168346	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [125I]NDP-alpha -MSH from human recombinant MT1 receptor after 240 mins by scintillation counting analysisDisplacement of [125I]NDP-alpha -MSH from human recombinant MT1 receptor after 240 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	1357	9263	139	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	1672	9263	139	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	224	9263	139	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	896	9263	139	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	CHEMBL45	9263	139	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	DB01065	9263	139	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	57781280	167743	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	2	1	3	3.1	CC(=O)NC/C=C1\CCc2ccc3nc(C)sc3c21	nan
	CHEMBL4115681	167743	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	2	1	3	3.1	CC(=O)NC/C=C1\CCc2ccc3nc(C)sc3c21	nan
	1357	9263	139	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
	1672	9263	139	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
	224	9263	139	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
	896	9263	139	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
	CHEMBL45	9263	139	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
	DB01065	9263	139	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
	1357	9263	139	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
	1672	9263	139	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
	224	9263	139	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
	896	9263	139	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
	CHEMBL45	9263	139	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
	DB01065	9263	139	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
	57781261	132637	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	284	4	1	3	3.1	Cc1nc2ccc3c(c2o1)C(CCNC(=O)C1CC1)CC3	nan
	CHEMBL3648368	132637	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	284	4	1	3	3.1	Cc1nc2ccc3c(c2o1)C(CCNC(=O)C1CC1)CC3	nan
	57781244	167612	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	270	3	1	3	3.0	CCC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21	nan
	CHEMBL4114700	167612	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	270	3	1	3	3.0	CCC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21	nan
	15340633	105005	1	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	3	1	2	2.8	CC(=O)NCCc1cccc2ccc3c(c12)CCCO3	10.1021/jm980026p
	CHEMBL274358	105005	1	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	3	1	2	2.8	CC(=O)NCCc1cccc2ccc3c(c12)CCCO3	10.1021/jm980026p
	15289276	123565	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	347	6	1	3	3.8	COc1ccc2cc(C(=O)c3ccccc3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL337764	123565	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	347	6	1	3	3.8	COc1ccc2cc(C(=O)c3ccccc3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	57781268	167609	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	256	2	1	3	2.6	CC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21	nan
	CHEMBL4114658	167609	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	256	2	1	3	2.6	CC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21	nan
	23725515	132634	0	None	-1	2	Human	9.4	pIC50	=	9.4	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	2.9	CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	nan
	CHEMBL3648365	132634	0	None	-1	2	Human	9.4	pIC50	=	9.4	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	2.9	CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	nan
	1357	9263	139	None	-1	9	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	1672	9263	139	None	-1	9	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	224	9263	139	None	-1	9	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	896	9263	139	None	-1	9	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	CHEMBL45	9263	139	None	-1	9	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	DB01065	9263	139	None	-1	9	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	1357	9263	139	None	-1	9	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human ML1A receptor by radioligand displacement assayBinding affinity to human ML1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2013.03.016
	1672	9263	139	None	-1	9	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human ML1A receptor by radioligand displacement assayBinding affinity to human ML1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2013.03.016
	224	9263	139	None	-1	9	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human ML1A receptor by radioligand displacement assayBinding affinity to human ML1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2013.03.016
	896	9263	139	None	-1	9	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human ML1A receptor by radioligand displacement assayBinding affinity to human ML1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2013.03.016
	CHEMBL45	9263	139	None	-1	9	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human ML1A receptor by radioligand displacement assayBinding affinity to human ML1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2013.03.016
	DB01065	9263	139	None	-1	9	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human ML1A receptor by radioligand displacement assayBinding affinity to human ML1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2013.03.016
	23725612	132636	0	None	-2	2	Human	9.3	pIC50	=	9.3	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	4	1	4	2.4	COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	nan
	CHEMBL3648367	132636	0	None	-2	2	Human	9.3	pIC50	=	9.3	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	4	1	4	2.4	COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	nan
	10059864	116600	5	None	2	2	Human	9.2	pIC50	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL323332	116600	5	None	2	2	Human	9.2	pIC50	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
	1357	9263	139	None	-1	9	Human	9.2	pIC50	=	9.2	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
	1672	9263	139	None	-1	9	Human	9.2	pIC50	=	9.2	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
	224	9263	139	None	-1	9	Human	9.2	pIC50	=	9.2	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
	896	9263	139	None	-1	9	Human	9.2	pIC50	=	9.2	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
	CHEMBL45	9263	139	None	-1	9	Human	9.2	pIC50	=	9.2	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
	DB01065	9263	139	None	-1	9	Human	9.2	pIC50	=	9.2	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
	57781246	132635	0	None	-2	2	Human	9.2	pIC50	=	9.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	284	4	1	3	3.3	CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21	nan
	CHEMBL3648366	132635	0	None	-2	2	Human	9.2	pIC50	=	9.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	284	4	1	3	3.3	CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21	nan
	44359126	35576	1	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	271	6	1	2	3.3	CCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	CHEMBL137878	35576	1	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	271	6	1	2	3.3	CCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	44359127	35715	1	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	5	1	2	2.9	CCOc1ccc2cccc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL137998	35715	1	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	5	1	2	2.9	CCOc1ccc2cccc(CCNC(C)=O)c2c1	10.1021/jm980026p
	594980	116468	13	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	286	4	2	2	2.4	COc1ccc2[nH]cc(CCNC(=O)C(F)(F)F)c2c1	10.1021/jm980026p
	CHEMBL322762	116468	13	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	286	4	2	2	2.4	COc1ccc2[nH]cc(CCNC(=O)C(F)(F)F)c2c1	10.1021/jm980026p
	9859969	181802	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	259	4	1	2	3.2	CSc1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	CHEMBL456727	181802	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	259	4	1	2	3.2	CSc1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	57781227	132623	0	None	-6	2	Human	9.1	pIC50	=	9.1	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	244	3	1	3	2.4	CC(=O)NCCC1CCc2ccc3ncoc3c21	nan
	CHEMBL3648354	132623	0	None	-6	2	Human	9.1	pIC50	=	9.1	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	244	3	1	3	2.4	CC(=O)NCCC1CCc2ccc3ncoc3c21	nan
	1357	9263	139	None	-1	9	Human	9.0	pIC50	=	9	Binding	Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980026p
	1672	9263	139	None	-1	9	Human	9.0	pIC50	=	9	Binding	Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980026p
	224	9263	139	None	-1	9	Human	9.0	pIC50	=	9	Binding	Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980026p
	896	9263	139	None	-1	9	Human	9.0	pIC50	=	9	Binding	Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980026p
	CHEMBL45	9263	139	None	-1	9	Human	9.0	pIC50	=	9	Binding	Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980026p
	DB01065	9263	139	None	-1	9	Human	9.0	pIC50	=	9	Binding	Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980026p
	115348	6858	47	None	4	2	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm980026p
	1343	6858	47	None	4	2	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm980026p
	CHEMBL289233	6858	47	None	4	2	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm980026p
	DB08190	6858	47	None	4	2	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm980026p
	9834952	36093	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	3	1	3	2.4	CC(=O)NCCc1coc2ccc3c(c12)CCCO3	10.1021/jm980026p
	CHEMBL138321	36093	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	3	1	3	2.4	CC(=O)NCCc1coc2ccc3c(c12)CCCO3	10.1021/jm980026p
	10265261	148740	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	272	2	1	3	2.7	COc1ccc2c(c1)c1c(n2C)CCCC1NC(C)=O	10.1021/jm980026p
	CHEMBL38728	148740	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	272	2	1	3	2.7	COc1ccc2c(c1)c1c(n2C)CCCC1NC(C)=O	10.1021/jm980026p
	34247	15022	4	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	4	1	3	2.6	COc1ccc2scc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL109235	15022	4	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	4	1	3	2.6	COc1ccc2scc(CCNC(C)=O)c2c1	10.1021/jm980026p
	9975634	16519	1	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	358	5	2	2	2.3	COc1ccc2[nH]cc(CCNC(=O)CI)c2c1	10.1021/jm980026p
	CHEMBL113441	16519	1	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	358	5	2	2	2.3	COc1ccc2[nH]cc(CCNC(=O)CI)c2c1	10.1021/jm980026p
	15340631	16614	1	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	253	3	1	2	3.3	CC(=O)NCCc1cccc2ccc3occc3c12	10.1021/jm980026p
	CHEMBL11404	16614	1	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	253	3	1	2	3.3	CC(=O)NCCc1cccc2ccc3occc3c12	10.1021/jm980026p
	164405	169530	9	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	5	1	2	2.9	COc1ccc2cccc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	CHEMBL417151	169530	9	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	5	1	2	2.9	COc1ccc2cccc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	10059864	116600	5	None	2	2	Human	8.8	pIC50	=	8.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL323332	116600	5	None	2	2	Human	8.8	pIC50	=	8.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	10061999	14809	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	276	5	2	2	2.4	COc1cc2c(CCNC(=O)C3CC3)c[nH]c2cc1F	10.1021/jm980026p
	CHEMBL109086	14809	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	276	5	2	2	2.4	COc1cc2c(CCNC(=O)C3CC3)c[nH]c2cc1F	10.1021/jm980026p
	44358991	36624	1	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	283	7	1	2	3.5	C=CCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	CHEMBL138766	36624	1	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	283	7	1	2	3.5	C=CCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	3071631	145438	7	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	5	1	2	2.9	CCC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL37771	145438	7	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	5	1	2	2.9	CCC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	10038961	16496	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	3	1	2	3.0	CC(=O)NCCC1CCCc2ccc3c(c21)CCCO3	10.1021/jm980026p
	CHEMBL11328	16496	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	3	1	2	3.0	CC(=O)NCCC1CCCc2ccc3c(c21)CCCO3	10.1021/jm980026p
	9993398	36060	2	None	-	0	Human	8.0	pIC50	=	8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	272	5	2	2	2.7	CCNC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL138288	36060	2	None	-	0	Human	8.0	pIC50	=	8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	272	5	2	2	2.7	CCNC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	10131203	125518	1	None	-	0	Human	8.0	pIC50	=	8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	4	1	3	2.2	CNC(=O)CCCc1cccc2c1SCCO2	10.1021/jm980026p
	CHEMBL341761	125518	1	None	-	0	Human	8.0	pIC50	=	8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	4	1	3	2.2	CNC(=O)CCCc1cccc2c1SCCO2	10.1021/jm980026p
	4284525	195493	42	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	275	4	3	3	2.0	COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL504585	195493	42	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	275	4	3	3	2.0	COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
	3071635	16175	4	None	-	0	Human	7.0	pIC50	=	7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	4	0	2	3.0	COc1ccc2cccc(CCN3CCCC3=O)c2c1	10.1021/jm980026p
	CHEMBL111558	16175	4	None	-	0	Human	7.0	pIC50	=	7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	4	0	2	3.0	COc1ccc2cccc(CCN3CCCC3=O)c2c1	10.1021/jm980026p
	21469690	35522	1	None	-	0	Human	7.0	pIC50	=	7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	262	4	2	2	2.9	CCc1ccc2scc(CCNC(=O)NC)c2c1	10.1021/jm980026p
	CHEMBL137823	35522	1	None	-	0	Human	7.0	pIC50	=	7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	262	4	2	2	2.9	CCc1ccc2scc(CCNC(=O)NC)c2c1	10.1021/jm980026p
	44359466	125934	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	283	6	1	4	1.9	CCS(=O)(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL342949	125934	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	283	6	1	4	1.9	CCS(=O)(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	4284525	195493	42	None	-	0	Human	6.0	pIC50	=	6	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	275	4	3	3	2.0	COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	CHEMBL504585	195493	42	None	-	0	Human	6.0	pIC50	=	6	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	275	4	3	3	2.0	COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	18177433	36168	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	4	1	3	1.8	COc1ccc2c(c1)CC(CCNC(C)=O)CO2	10.1021/jm980026p
	CHEMBL138387	36168	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	4	1	3	1.8	COc1ccc2c(c1)CC(CCNC(C)=O)CO2	10.1021/jm980026p
	44358869	125648	1	None	-	0	Human	6.0	pIC50	=	6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	229	4	1	2	2.3	COc1ccc2cccc(CCC(N)=O)c2c1	10.1021/jm980026p
	CHEMBL342207	125648	1	None	-	0	Human	6.0	pIC50	=	6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	229	4	1	2	2.3	COc1ccc2cccc(CCC(N)=O)c2c1	10.1021/jm980026p
	18357874	171827	2	None	-	0	Human	6.0	pIC50	=	6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	219	3	1	3	1.8	CC(=O)NCCC1=COc2ccccc2O1	10.1021/jm980026p
	CHEMBL422636	171827	2	None	-	0	Human	6.0	pIC50	=	6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	219	3	1	3	1.8	CC(=O)NCCC1=COc2ccccc2O1	10.1021/jm980026p
	19703067	35690	2	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	203	3	1	3	1.2	CC(=O)NCCn1ccc2cccnc21	10.1021/jm980026p
	CHEMBL137970	35690	2	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	203	3	1	3	1.2	CC(=O)NCCn1ccc2cccnc21	10.1021/jm980026p
	12288745	36076	2	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	221	2	1	3	1.1	COc1ccc2c(c1)CC(NC(C)=O)CO2	10.1021/jm980026p
	CHEMBL138301	36076	2	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	221	2	1	3	1.1	COc1ccc2c(c1)CC(NC(C)=O)CO2	10.1021/jm980026p
	19703053	36265	2	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	234	4	1	4	1.5	COc1nccc2c(CCNC(C)=O)coc12	10.1021/jm980026p
	CHEMBL138468	36265	2	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	234	4	1	4	1.5	COc1nccc2c(CCNC(C)=O)coc12	10.1021/jm980026p
	18175018	36310	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	260	4	2	2	2.2	CC(=O)NCCC1CCc2ccc(NC(C)=O)cc21	10.1021/jm980026p
	CHEMBL138508	36310	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	260	4	2	2	2.2	CC(=O)NCCC1CCc2ccc(NC(C)=O)cc21	10.1021/jm980026p
	15838838	37023	3	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	207	2	1	3	1.1	CC(=O)NCc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL139091	37023	3	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	207	2	1	3	1.1	CC(=O)NCc1cccc2c1OCCO2	10.1021/jm980026p
	15372705	37407	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	4	1	4	3.0	COc1ccc2c(c1)OC(CNC(C)=O)=C(c1ccccc1)O2	10.1021/jm980026p
	CHEMBL139418	37407	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	4	1	4	3.0	COc1ccc2c(c1)OC(CNC(C)=O)=C(c1ccccc1)O2	10.1021/jm980026p
	15391788	38479	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	1	1	4	0.9	CC(=O)NC1COc2cc3c(cc2C1)OCCO3	10.1021/jm980026p
	CHEMBL140548	38479	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	1	1	4	0.9	CC(=O)NC1COc2cc3c(cc2C1)OCCO3	10.1021/jm980026p
	44359047	126029	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	3	1	4	0.5	CNC(=O)CCc1cccc2c1S(=O)(=O)CCO2	10.1021/jm980026p
	CHEMBL343575	126029	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	3	1	4	0.5	CNC(=O)CCc1cccc2c1S(=O)(=O)CCO2	10.1021/jm980026p
	15149134	106978	1	None	-	0	Human	4.0	pIC50	=	4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	313	9	1	2	4.5	CCCCCCC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL288300	106978	1	None	-	0	Human	4.0	pIC50	=	4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	313	9	1	2	4.5	CCCCCCC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	44359375	125999	3	None	-	0	Human	4.0	pIC50	=	4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	211	1	1	1	2.4	O=C1CC(c2cccc3ccccc23)CN1	10.1021/jm980026p
	CHEMBL343381	125999	3	None	-	0	Human	4.0	pIC50	=	4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	211	1	1	1	2.4	O=C1CC(c2cccc3ccccc23)CN1	10.1021/jm980026p
	23725566	132629	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648360	132629	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	nan
	44272486	76603	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	302	3	0	3	2.5	COc1ccc2c(c1)[C@H](N1CCN(C(=O)C(C)C)CC1)CC2	10.1016/s0960-894x(03)00090-8
	CHEMBL19374	76603	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	302	3	0	3	2.5	COc1ccc2c(c1)[C@H](N1CCN(C(=O)C(C)C)CC1)CC2	10.1016/s0960-894x(03)00090-8
	44358830	37181	2	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	5	1	4	1.5	COc1ccc2occ(CCNS(C)(=O)=O)c2c1	10.1021/jm980026p
	CHEMBL139228	37181	2	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	5	1	4	1.5	COc1ccc2occ(CCNS(C)(=O)=O)c2c1	10.1021/jm980026p
	44359427	37488	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	373	5	1	2	3.1	COc1ccc2c(c1)C(CCNC(=O)CI)CCC2	10.1021/jm980026p
	CHEMBL139516	37488	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	373	5	1	2	3.1	COc1ccc2c(c1)C(CCNC(=O)CI)CCC2	10.1021/jm980026p
	19696845	123311	1	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	243	4	1	2	2.5	CNC(=O)CCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL336225	123311	1	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	243	4	1	2	2.5	CNC(=O)CCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	44359390	125784	1	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	295	7	1	2	3.5	C=CCOc1ccc2cccc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	CHEMBL342592	125784	1	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	295	7	1	2	3.5	C=CCOc1ccc2cccc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	19385775	126207	1	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	274	4	2	2	2.9	CN/C(S)=N/CCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL344880	126207	1	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	274	4	2	2	2.9	CN/C(S)=N/CCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	44576404	199886	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	286	5	2	3	1.9	CNC(=O)c1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL522674	199886	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	286	5	2	3	1.9	CNC(=O)c1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1016/j.bmc.2008.03.036
	10399169	35664	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	235	4	1	3	1.5	CC(=O)NCCCc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL137948	35664	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	235	4	1	3	1.5	CC(=O)NCCCc1cccc2c1OCCO2	10.1021/jm980026p
	19703063	35688	1	None	2	2	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1021/jm980026p
	CHEMBL137969	35688	1	None	2	2	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1021/jm980026p
	23360853	38823	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	6	1	3	3.1	COc1ccc2cc(C(C)=O)cc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	CHEMBL140826	38823	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	6	1	3	3.1	COc1ccc2cc(C(C)=O)cc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	44359206	126156	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	265	5	1	3	2.6	CC(=O)NCCCCc1cccc2c1SCCO2	10.1021/jm980026p
	CHEMBL344488	126156	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	265	5	1	3	2.6	CC(=O)NCCCCc1cccc2c1SCCO2	10.1021/jm980026p
	44359079	172035	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	247	5	1	3	2.5	CCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL423011	172035	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	247	5	1	3	2.5	CCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	44358887	33635	1	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	215	2	1	2	2.2	CNC(=O)c1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL136346	33635	1	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	215	2	1	2	2.2	CNC(=O)c1cccc2ccc(OC)cc12	10.1021/jm980026p
	44359058	36452	4	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	203	3	2	2	1.2	CC(=O)NCCc1c[nH]c2ncccc12	10.1021/jm980026p
	CHEMBL138631	36452	4	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	203	3	2	2	1.2	CC(=O)NCCc1c[nH]c2ncccc12	10.1021/jm980026p
	23725513	132626	0	None	-3	2	Human	7.8	pIC50	=	7.8	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648357	132626	0	None	-3	2	Human	7.8	pIC50	=	7.8	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	nan
	15340629	16638	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	3	1	3	2.1	CC(=O)NCCc1cccc2ccc3c(c12)C(=O)CO3	10.1021/jm980026p
	CHEMBL11416	16638	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	3	1	3	2.1	CC(=O)NCCc1cccc2ccc3c(c12)C(=O)CO3	10.1021/jm980026p
	44359205	35704	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	299	8	1	2	4.1	CCCCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	CHEMBL137983	35704	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	299	8	1	2	4.1	CCCCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	44358971	35762	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	5	1	3	2.1	C#CCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138037	35762	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	5	1	3	2.1	C#CCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	10059969	35784	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	235	4	1	3	1.5	CNC(=O)CCCc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL138053	35784	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	235	4	1	3	1.5	CNC(=O)CCCc1cccc2c1OCCO2	10.1021/jm980026p
	15289277	35963	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	333	6	1	2	4.1	COc1ccc2cc(Cc3ccccc3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138201	35963	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	333	6	1	2	4.1	COc1ccc2cc(Cc3ccccc3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	23360848	168450	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	6	1	2	3.5	CCc1cc(CCNC(=O)C2CC2)c2cc(OC)ccc2c1	10.1021/jm980026p
	CHEMBL413121	168450	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	6	1	2	3.5	CCc1cc(CCNC(=O)C2CC2)c2cc(OC)ccc2c1	10.1021/jm980026p
	22375366	76268	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	300	3	0	3	2.2	COc1ccc2c(c1)C(N1CCN(C(=O)C3CC3)CC1)CC2	10.1016/s0960-894x(03)00090-8
	CHEMBL19339	76268	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	300	3	0	3	2.2	COc1ccc2c(c1)C(N1CCN(C(=O)C3CC3)CC1)CC2	10.1016/s0960-894x(03)00090-8
	44358744	33481	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	5	1	3	1.9	CC(=O)NCCCCc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL136214	33481	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	5	1	3	1.9	CC(=O)NCCCCc1cccc2c1OCCO2	10.1021/jm980026p
	15340628	34190	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	287	6	2	3	2.0	CC(=O)NCCc1cccc2ccc(OCC(=O)O)cc12	10.1021/jm980026p
	CHEMBL136815	34190	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	287	6	2	3	2.0	CC(=O)NCCc1cccc2ccc(OCC(=O)O)cc12	10.1021/jm980026p
	10060719	177215	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	4	1	3	2.2	CC(=O)NCCCc1cccc2c1SCCO2	10.1021/jm980026p
	CHEMBL444857	177215	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	4	1	3	2.2	CC(=O)NCCCc1cccc2c1SCCO2	10.1021/jm980026p
	44359046	36635	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	265	6	1	4	1.8	CC(=O)NCCCCOc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL138774	36635	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	265	6	1	4	1.8	CC(=O)NCCCCOc1cccc2c1OCCO2	10.1021/jm980026p
	18782997	39975	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	277	6	2	4	1.6	CC(=O)NCCc1coc2ccc(OCC(=O)O)cc12	10.1021/jm980026p
	CHEMBL141785	39975	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	277	6	2	4	1.6	CC(=O)NCCc1coc2ccc(OCC(=O)O)cc12	10.1021/jm980026p
	19703028	125921	2	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	204	3	1	3	1.5	CC(=O)NCCc1coc2cnccc12	10.1021/jm980026p
	CHEMBL342836	125921	2	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	204	3	1	3	1.5	CC(=O)NCCc1coc2cnccc12	10.1021/jm980026p
	44359374	126178	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	241	2	1	2	2.5	COc1ccc2cccc(C3CNC(=O)C3)c2c1	10.1021/jm980026p
	CHEMBL344632	126178	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	241	2	1	2	2.5	COc1ccc2cccc(C3CNC(=O)C3)c2c1	10.1021/jm980026p
	21460931	175234	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	245	5	1	2	3.1	CCCc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL435032	175234	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	245	5	1	2	3.1	CCCc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	15391785	35937	1	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	3	1	3	1.6	COc1ccc2c(c1)C=C(CNC(C)=O)CO2	10.1021/jm980026p
	CHEMBL138180	35937	1	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	3	1	3	1.6	COc1ccc2c(c1)C=C(CNC(C)=O)CO2	10.1021/jm980026p
	44358928	36941	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	333	7	1	2	4.1	COc1ccc2cccc(CC(=O)NCCCc3ccccc3)c2c1	10.1021/jm980026p
	CHEMBL139016	36941	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	333	7	1	2	4.1	COc1ccc2cccc(CC(=O)NCCCc3ccccc3)c2c1	10.1021/jm980026p
	44359070	39572	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	205	3	1	3	0.6	CC(=O)NCCN1CCc2cccnc21	10.1021/jm980026p
	CHEMBL141430	39572	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	205	3	1	3	0.6	CC(=O)NCCN1CCc2cccnc21	10.1021/jm980026p
	22375372	74032	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	302	3	0	3	2.5	COc1ccc2c(c1)C(N1CCN(C(=O)C(C)C)CC1)CC2	10.1016/s0960-894x(03)00090-8
	CHEMBL18808	74032	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	302	3	0	3	2.5	COc1ccc2c(c1)C(N1CCN(C(=O)C(C)C)CC1)CC2	10.1016/s0960-894x(03)00090-8
	11059058	16863	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity against melatonin receptor type 1ABinding affinity against melatonin receptor type 1A	ChEMBL	429	3	1	7	4.1	O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1	10.1021/jm010878g
	CHEMBL115444	16863	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity against melatonin receptor type 1ABinding affinity against melatonin receptor type 1A	ChEMBL	429	3	1	7	4.1	O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1	10.1021/jm010878g
	44576399	195565	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	260	4	2	3	1.5	CNC(=O)c1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL505744	195565	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	260	4	2	3	1.5	CNC(=O)c1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
	23725568	132633	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCC[C@H]1CCc2ccc3nc(C)sc3c21	nan
	CHEMBL3648364	132633	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCC[C@H]1CCc2ccc3nc(C)sc3c21	nan
	10039072	35665	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	6	3	2	2.4	CCCNC(=O)NCCc1c[nH]c2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL137949	35665	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	6	3	2	2.4	CCCNC(=O)NCCc1c[nH]c2ccc(OC)cc12	10.1021/jm980026p
	10377971	36298	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	5	1	3	2.4	CCCC(=O)NCC1=Cc2cc(OC)ccc2OC1	10.1021/jm980026p
	CHEMBL138496	36298	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	5	1	3	2.4	CCCC(=O)NCC1=Cc2cc(OC)ccc2OC1	10.1021/jm980026p
	44359437	36673	0	None	1	3	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138807	36673	0	None	1	3	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1021/jm980026p
	19752678	36675	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	243	5	1	2	2.7	COc1ccc2cccc(CCCC(N)=O)c2c1	10.1021/jm980026p
	CHEMBL138808	36675	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	243	5	1	2	2.7	COc1ccc2cccc(CCCC(N)=O)c2c1	10.1021/jm980026p
	10448305	36832	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	313	9	1	2	4.5	CCCCCCOc1ccc2cccc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138924	36832	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	313	9	1	2	4.5	CCCCCCOc1ccc2cccc(CCNC(C)=O)c2c1	10.1021/jm980026p
	44359018	126222	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	5	1	3	2.5	COc1ccc2occ(CCNC(=O)CBr)c2c1	10.1021/jm980026p
	CHEMBL345029	126222	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	5	1	3	2.5	COc1ccc2occ(CCNC(=O)CBr)c2c1	10.1021/jm980026p
	44358910	34191	1	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	7	1	2	3.7	CCCOc1ccc2cccc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	CHEMBL136816	34191	1	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	7	1	2	3.7	CCCOc1ccc2cccc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	2821758	36130	15	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	207	2	1	3	1.0	CC(=O)NCC1COc2ccccc2O1	10.1021/jm980026p
	CHEMBL138355	36130	15	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	207	2	1	3	1.0	CC(=O)NCC1COc2ccccc2O1	10.1021/jm980026p
	44358944	39676	3	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	286	9	2	1	4.2	CCCCCCCC(=O)NCCc1c[nH]c2ccccc12	10.1021/jm980026p
	CHEMBL141522	39676	3	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	286	9	2	1	4.2	CCCCCCCC(=O)NCCc1c[nH]c2ccccc12	10.1021/jm980026p
	15149133	126793	1	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	299	8	1	2	4.1	CCCCCC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL35017	126793	1	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	299	8	1	2	4.1	CCCCCC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	53827707	117643	3	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK293 cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	279	6	1	3	3.0	CCCNC(=O)CCCc1cccc2c1SCCO2	10.1021/jm401343c
	CHEMBL3260981	117643	3	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK293 cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	279	6	1	3	3.0	CCCNC(=O)CCCc1cccc2c1SCCO2	10.1021/jm401343c
	18360745	36687	1	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	258	4	2	2	2.3	CNC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL138817	36687	1	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	258	4	2	2	2.3	CNC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	3071630	145017	6	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	271	5	1	2	3.2	COc1ccc2cccc(CCNC(=O)C(C)C)c2c1	10.1021/jm980026p
	CHEMBL37703	145017	6	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	271	5	1	2	3.2	COc1ccc2cccc(CCNC(=O)C(C)C)c2c1	10.1021/jm980026p
	10266979	105795	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	303	3	1	3	2.0	CCNC(=O)N1CCN([C@@H]2CCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
	CHEMBL280142	105795	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	303	3	1	3	2.0	CCNC(=O)N1CCN([C@@H]2CCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
	11178762	73780	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	463	5	0	2	6.1	COc1cc2c(cc1Br)CCN(C(C)=O)C2CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
	CHEMBL186941	73780	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	463	5	0	2	6.1	COc1cc2c(cc1Br)CCN(C(C)=O)C2CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
	44340895	16191	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	219	3	1	2	1.9	COc1ccc2c(c1)C(CNC(C)=O)CC2	10.1021/jm980026p
	CHEMBL111667	16191	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	219	3	1	2	1.9	COc1ccc2c(c1)C(CNC(C)=O)CC2	10.1021/jm980026p
	44359479	36946	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	277	6	1	3	3.4	CCCOc1ccc2scc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL139021	36946	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	277	6	1	3	3.4	CCCOc1ccc2scc(CCNC(C)=O)c2c1	10.1021/jm980026p
	44359019	38372	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	6	1	3	2.7	C=CCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL140427	38372	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	6	1	3	2.7	C=CCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	19086015	37416	4	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	300	7	2	2	3.5	CCCNC(=O)NCCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL139428	37416	4	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	300	7	2	2	3.5	CCCNC(=O)NCCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	19703043	126104	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	5	1	4	1.7	COc1cnc2c(c1)c(CCNC(=O)C1CC1)cn2C	10.1021/jm980026p
	CHEMBL344179	126104	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	5	1	4	1.7	COc1cnc2c(c1)c(CCNC(=O)C1CC1)cn2C	10.1021/jm980026p
	3071647	143122	3	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	344	5	2	2	4.3	COc1ccc2cccc(CCNC(=O)c3cc4ccccc4[nH]3)c2c1	10.1021/jm980026p
	CHEMBL37341	143122	3	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	344	5	2	2	4.3	COc1ccc2cccc(CCNC(=O)c3cc4ccccc4[nH]3)c2c1	10.1021/jm980026p
	9064	111996	94	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cellsAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells	ChEMBL	290	1	5	6	1.5	Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2	10.1016/j.bmc.2021.116270
	CHEMBL311498	111996	94	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cellsAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells	ChEMBL	290	1	5	6	1.5	Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2	10.1016/j.bmc.2021.116270
	18175032	182375	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	358	6	2	4	2.3	CNS(=O)(=O)c1ccc2cccc(CCNC(=O)c3ccco3)c2c1	10.1016/j.ejmech.2011.02.010
	CHEMBL457992	182375	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	358	6	2	4	2.3	CNS(=O)(=O)c1ccc2cccc(CCNC(=O)c3ccco3)c2c1	10.1016/j.ejmech.2011.02.010
	44593610	194151	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	302	6	2	4	2.8	C=CCC(=O)NCCc1coc2ccc(NC(=O)OC)cc12	10.1016/j.bmc.2008.03.036
	CHEMBL493424	194151	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	302	6	2	4	2.8	C=CCC(=O)NCCc1coc2ccc(NC(=O)OC)cc12	10.1016/j.bmc.2008.03.036
	44359035	38481	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	285	7	1	2	3.7	CCCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	CHEMBL140549	38481	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	285	7	1	2	3.7	CCCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	18947294	39181	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	248	4	2	3	1.9	CNC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL141115	39181	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	248	4	2	3	1.9	CNC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	44359270	175385	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	283	6	2	2	3.3	C=CCc1c(O)ccc2cccc(CCNC(=O)CC)c12	10.1021/jm980026p
	CHEMBL436006	175385	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	283	6	2	2	3.3	C=CCc1c(O)ccc2cccc(CCNC(=O)CC)c12	10.1021/jm980026p
	10333620	115981	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	5	1	3	3.0	COc1ccc2scc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	CHEMBL321612	115981	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	5	1	3	3.0	COc1ccc2scc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	44359308	122268	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	244	4	2	2	2.1	COc1ccc2cccc(CCNC(N)=O)c2c1	10.1021/jm980026p
	CHEMBL335116	122268	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	244	4	2	2	2.1	COc1ccc2cccc(CCNC(N)=O)c2c1	10.1021/jm980026p
	18783022	123534	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	3	1	3	2.5	CC(=O)NCCc1coc2ccc3c(c12)C=CCO3	10.1021/jm980026p
	CHEMBL337580	123534	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	3	1	3	2.5	CC(=O)NCCc1coc2ccc3c(c12)C=CCO3	10.1021/jm980026p
	19967248	176098	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	6	1	3	3.2	CCCC(=O)NOCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL441664	176098	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	6	1	3	3.2	CCCC(=O)NOCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	18175008	182274	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	292	4	2	3	1.2	CC(=O)NCCc1cccc2ccc(S(N)(=O)=O)cc12	10.1016/j.ejmech.2011.02.010
	CHEMBL457763	182274	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	292	4	2	3	1.2	CC(=O)NCCc1cccc2ccc(S(N)(=O)=O)cc12	10.1016/j.ejmech.2011.02.010
	44358896	37483	2	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	228	3	2	1	2.3	CNC(=O)NCCc1cccc2ccccc12	10.1021/jm980026p
	CHEMBL139510	37483	2	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	228	3	2	1	2.3	CNC(=O)NCCc1cccc2ccccc12	10.1021/jm980026p
	44358943	38170	1	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	5	1	2	4.2	CC(=O)NCCc1cccc2ccc(OC3CCCCC3)cc12	10.1021/jm980026p
	CHEMBL140244	38170	1	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	5	1	2	4.2	CC(=O)NCCc1cccc2ccc(OC3CCCCC3)cc12	10.1021/jm980026p
	10243074	16570	2	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	4	1	4	1.2	COc1ccc2ncn(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL113692	16570	2	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	4	1	4	1.2	COc1ccc2ncn(CCNC(C)=O)c2c1	10.1021/jm980026p
	44359228	37076	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	237	4	1	4	1.0	CC(=O)NCCOc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL139133	37076	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	237	4	1	4	1.0	CC(=O)NCCOc1cccc2c1OCCO2	10.1021/jm980026p
	15372706	126205	1	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	281	3	1	3	3.0	CC(=O)NCC1=C(c2ccccc2)Oc2ccccc2O1	10.1021/jm980026p
	CHEMBL344866	126205	1	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	281	3	1	3	3.0	CC(=O)NCC1=C(c2ccccc2)Oc2ccccc2O1	10.1021/jm980026p
	9861677	194338	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	315	5	1	4	3.1	COC(=O)c1ccc2occ(CCNC(=O)C3CCCC3)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL494566	194338	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	315	5	1	4	3.1	COC(=O)c1ccc2occ(CCNC(=O)C3CCCC3)c2c1	10.1016/j.bmc.2008.03.036
	10379422	15209	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	289	5	1	3	3.4	COc1ccc2scc(CCNC(=O)C3CCC3)c2c1	10.1021/jm980026p
	CHEMBL109361	15209	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	289	5	1	3	3.4	COc1ccc2scc(CCNC(=O)C3CCC3)c2c1	10.1021/jm980026p
	15391789	36386	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	235	3	1	3	1.4	COc1ccc2c(c1)CC(CNC(C)=O)CO2	10.1021/jm980026p
	CHEMBL138581	36386	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	235	3	1	3	1.4	COc1ccc2c(c1)CC(CNC(C)=O)CO2	10.1021/jm980026p
	23360817	37565	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	6	1	3	3.1	COc1ccc2cc(C(=O)C3CC3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL139627	37565	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	6	1	3	3.1	COc1ccc2cc(C(=O)C3CC3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	44359020	38378	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	337	7	1	3	4.1	CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL140433	38378	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	337	7	1	3	4.1	CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm980026p
	44358768	123572	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	6	1	3	2.8	CCCC(=O)NCCCc1cccc2c1OC=CO2	10.1021/jm980026p
	CHEMBL337802	123572	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	6	1	3	2.8	CCCC(=O)NCCCc1cccc2c1OC=CO2	10.1021/jm980026p
	44358840	125525	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	4	1	3	2.7	COC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL341802	125525	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	4	1	3	2.7	COC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	2368416	106857	5	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	242	4	2	1	2.6	O=C(NCCc1c[nH]c2ccccc12)C1CCC1	10.1021/jm980026p
	CHEMBL287310	106857	5	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	242	4	2	1	2.6	O=C(NCCc1c[nH]c2ccccc12)C1CCC1	10.1021/jm980026p
	44272591	78480	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	300	3	0	3	2.2	COc1ccc2c(c1)[C@H](N1CCN(C(=O)C3CC3)CC1)CC2	10.1016/s0960-894x(03)00090-8
	CHEMBL19653	78480	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	300	3	0	3	2.2	COc1ccc2c(c1)[C@H](N1CCN(C(=O)C3CC3)CC1)CC2	10.1016/s0960-894x(03)00090-8
	21916760	182478	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	291	4	1	3	1.9	CC(=O)NCCc1cccc2ccc(S(C)(=O)=O)cc12	10.1016/j.ejmech.2011.02.010
	CHEMBL458209	182478	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	291	4	1	3	1.9	CC(=O)NCCc1cccc2ccc(S(C)(=O)=O)cc12	10.1016/j.ejmech.2011.02.010
	10422677	16076	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	5	1	3	2.5	COc1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	CHEMBL110980	16076	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	5	1	3	2.5	COc1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	18783019	35613	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	267	5	1	2	2.5	C#CCOc1ccc2cccc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL137910	35613	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	267	5	1	2	2.5	C#CCOc1ccc2cccc(CCNC(C)=O)c2c1	10.1021/jm980026p
	44359309	36230	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	4	2	3	2.0	COc1ccc2cccc(C(O)CNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138440	36230	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	4	2	3	2.0	COc1ccc2cccc(C(O)CNC(C)=O)c2c1	10.1021/jm980026p
	9881916	36609	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	271	2	1	3	2.3	COc1ccc2ccc3c(c2c1)CC(NC(C)=O)CO3	10.1021/jm980026p
	CHEMBL138752	36609	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	271	2	1	3	2.3	COc1ccc2ccc3c(c2c1)CC(NC(C)=O)CO3	10.1021/jm980026p
	10248871	115342	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	375	5	1	3	3.0	COc1ccc2scc(CCNC(=O)CI)c2c1	10.1021/jm980026p
	CHEMBL320253	115342	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	375	5	1	3	3.0	COc1ccc2scc(CCNC(=O)CI)c2c1	10.1021/jm980026p
	44359464	36721	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	7	1	3	3.3	CCCCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138841	36721	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	7	1	3	3.3	CCCCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	18947318	125576	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	293	6	3	2	2.6	CCCNC(=O)NCCc1c[nH]c2cc(F)c(OC)cc12	10.1021/jm980026p
	CHEMBL342162	125576	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	293	6	3	2	2.6	CCCNC(=O)NCCc1c[nH]c2cc(F)c(OC)cc12	10.1021/jm980026p
	44358743	125820	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	5	1	3	1.9	CNC(=O)CCCCc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL342649	125820	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	5	1	3	1.9	CNC(=O)CCCCc1cccc2c1OCCO2	10.1021/jm980026p
	23360832	126061	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	299	6	1	3	3.1	CCC(=O)c1cc(CCNC(C)=O)c2cc(OC)ccc2c1	10.1021/jm980026p
	CHEMBL343819	126061	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	299	6	1	3	3.1	CCC(=O)c1cc(CCNC(C)=O)c2cc(OC)ccc2c1	10.1021/jm980026p
	22133298	126151	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	286	6	2	2	3.1	CCCNC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL344454	126151	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	286	6	2	2	3.1	CCCNC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	18175028	66853	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	306	5	2	3	1.4	CNS(=O)(=O)c1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	CHEMBL1738752	66853	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	306	5	2	3	1.4	CNS(=O)(=O)c1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	10085672	36279	1	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	291	7	1	3	3.8	CCCCC(=O)NCCc1csc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL138475	36279	1	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	291	7	1	3	3.8	CCCCC(=O)NCCc1csc2ccc(OC)cc12	10.1021/jm980026p
	21572387	36513	3	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	214	3	2	1	2.1	NC(=O)NCCc1cccc2ccccc12	10.1021/jm980026p
	CHEMBL138675	36513	3	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	214	3	2	1	2.1	NC(=O)NCCc1cccc2ccccc12	10.1021/jm980026p
	44359120	36849	1	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	4	1	2	3.4	O=C(NCCc1csc2ccccc12)C1CCC1	10.1021/jm980026p
	CHEMBL138938	36849	1	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	4	1	2	3.4	O=C(NCCc1csc2ccccc12)C1CCC1	10.1021/jm980026p
	9837777	38911	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	247	4	1	4	1.3	COc1cnc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm980026p
	CHEMBL140896	38911	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	247	4	1	4	1.3	COc1cnc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm980026p
	15838839	39993	2	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	221	3	1	3	1.1	CC(=O)NCCc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL141796	39993	2	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	221	3	1	3	1.1	CC(=O)NCCc1cccc2c1OCCO2	10.1021/jm980026p
	11749479	73672	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	385	5	0	2	5.4	COc1ccc2c(c1)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2	10.1016/j.bmcl.2004.09.024
	CHEMBL186452	73672	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	385	5	0	2	5.4	COc1ccc2c(c1)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2	10.1016/j.bmcl.2004.09.024
	44576406	194149	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	330	5	2	4	3.5	COC(=O)Nc1ccc2occ(CCNC(=O)C3CCCC3)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL493414	194149	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	330	5	2	4	3.5	COC(=O)Nc1ccc2occ(CCNC(=O)C3CCCC3)c2c1	10.1016/j.bmc.2008.03.036
	17957007	199434	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	304	5	2	4	2.9	COC(=O)Nc1ccc2occ(CCNC(=O)C(C)C)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL521826	199434	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	304	5	2	4	2.9	COC(=O)Nc1ccc2occ(CCNC(=O)C(C)C)c2c1	10.1016/j.bmc.2008.03.036
	10265421	16205	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	7	1	3	3.3	CCCCC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL111718	16205	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	7	1	3	3.3	CCCCC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	44359121	36938	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	313	9	1	2	4.5	CCCCCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	CHEMBL139014	36938	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	313	9	1	2	4.5	CCCCCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	23360808	37399	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	285	6	1	2	3.5	CCCc1cc(CCNC(C)=O)c2cc(OC)ccc2c1	10.1021/jm980026p
	CHEMBL139410	37399	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	285	6	1	2	3.5	CCCc1cc(CCNC(C)=O)c2cc(OC)ccc2c1	10.1021/jm980026p
	11361621	132585	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	401	7	0	3	5.0	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C=O)CC2	10.1016/j.bmcl.2004.09.024
	CHEMBL364816	132585	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	401	7	0	3	5.0	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C=O)CC2	10.1016/j.bmcl.2004.09.024
	18177435	35940	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	285	3	1	3	2.5	COc1ccc2ccc3c(c2c1)CC(CNC(C)=O)CO3	10.1021/jm980026p
	CHEMBL138182	35940	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	285	3	1	3	2.5	COc1ccc2ccc3c(c2c1)CC(CNC(C)=O)CO3	10.1021/jm980026p
	21469691	125924	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	5	1	2	3.5	CCC(=O)NCCc1csc2ccc(CC)cc12	10.1021/jm980026p
	CHEMBL342855	125924	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	5	1	2	3.5	CCC(=O)NCCc1csc2ccc(CC)cc12	10.1021/jm980026p
	21469682	38549	1	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	289	7	1	2	4.3	CCCCC(=O)NCCc1csc2ccc(CC)cc12	10.1021/jm980026p
	CHEMBL140611	38549	1	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	289	7	1	2	4.3	CCCCC(=O)NCCc1csc2ccc(CC)cc12	10.1021/jm980026p
	44359381	39292	1	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	5	1	4	1.4	CC(=O)NCCCOc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL141208	39292	1	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	5	1	4	1.4	CC(=O)NCCCOc1cccc2c1OCCO2	10.1021/jm980026p
	44359294	123566	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	406	8	4	3	3.8	COc1ccc2[nH]cc(CCNC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1021/jm980026p
	CHEMBL337767	123566	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	406	8	4	3	3.8	COc1ccc2[nH]cc(CCNC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1021/jm980026p
	17524911	38833	4	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	256	4	2	1	3.0	O=C(NCCc1c[nH]c2ccccc12)C1CCCC1	10.1021/jm980026p
	CHEMBL140835	38833	4	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	256	4	2	1	3.0	O=C(NCCc1c[nH]c2ccccc12)C1CCCC1	10.1021/jm980026p
	588712	39870	10	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	244	6	2	1	3.0	CCCCC(=O)NCCc1c[nH]c2ccccc12	10.1021/jm980026p
	CHEMBL141694	39870	10	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	244	6	2	1	3.0	CCCCC(=O)NCCc1c[nH]c2ccccc12	10.1021/jm980026p
	11430378	174998	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	431	6	0	4	5.6	COC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
	CHEMBL433573	174998	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	431	6	0	4	5.6	COC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
	9837740	36355	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	245	4	1	3	2.4	COc1ccc2cccc(CONC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138549	36355	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	245	4	1	3	2.4	COc1ccc2cccc(CONC(C)=O)c2c1	10.1021/jm980026p
	44359113	123180	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	7	1	2	3.7	CCC(=O)NCCc1cccc2ccc(OCC3CC3)cc12	10.1021/jm980026p
	CHEMBL336010	123180	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	7	1	2	3.7	CCC(=O)NCCc1cccc2ccc(OCC3CC3)cc12	10.1021/jm980026p
	23360842	125755	1	None	-	1	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	6	1	2	3.5	COc1ccc2cc(CC3CC3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL342432	125755	1	None	-	1	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	6	1	2	3.5	COc1ccc2cc(CC3CC3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	44358970	125821	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	359	5	1	3	2.5	COc1ccc2occ(CCNC(=O)CI)c2c1	10.1021/jm980026p
	CHEMBL342655	125821	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	359	5	1	3	2.5	COc1ccc2occ(CCNC(=O)CI)c2c1	10.1021/jm980026p
	18947325	126121	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	262	5	2	3	2.3	CCNC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL344268	126121	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	262	5	2	3	2.3	CCNC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	9817006	181763	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	275	4	1	2	2.3	CC(=O)NCCc1cccc2ccc([S+](C)[O-])cc12	10.1016/j.ejmech.2011.02.010
	CHEMBL456646	181763	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	275	4	1	2	2.3	CC(=O)NCCc1cccc2ccc([S+](C)[O-])cc12	10.1016/j.ejmech.2011.02.010
	44358879	36839	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	6	1	2	3.7	CCOc1ccc2cccc(CCNC(=O)C3CCC3)c2c1	10.1021/jm980026p
	CHEMBL138929	36839	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	6	1	2	3.7	CCOc1ccc2cccc(CCNC(=O)C3CCC3)c2c1	10.1021/jm980026p
	44359266	38482	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	316	4	0	5	2.2	COc1ccc2c(c1)c(CCN(C(C)=O)C(C)=O)cn2C(C)=O	10.1021/jm980026p
	CHEMBL140551	38482	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	316	4	0	5	2.2	COc1ccc2c(c1)c(CCN(C(C)=O)C(C)=O)cn2C(C)=O	10.1021/jm980026p
	18947270	39662	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	276	6	2	3	2.7	CCCNC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL141507	39662	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	276	6	2	3	2.7	CCCNC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	44359465	125556	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	5	1	3	2.9	CC(=O)NCCc1coc2ccc(OC(C)C)cc12	10.1021/jm980026p
	CHEMBL341989	125556	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	5	1	3	2.9	CC(=O)NCCc1coc2ccc(OC(C)C)cc12	10.1021/jm980026p
	21469693	37653	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	290	6	2	2	3.7	CCCNC(=O)NCCc1csc2ccc(CC)cc12	10.1021/jm980026p
	CHEMBL139744	37653	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	290	6	2	2	3.7	CCCNC(=O)NCCc1csc2ccc(CC)cc12	10.1021/jm980026p
	18177465	126118	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	4	1	4	1.4	COc1ccc2c(c1)OC(CCNC(C)=O)CO2	10.1021/jm980026p
	CHEMBL344242	126118	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	4	1	4	1.4	COc1ccc2c(c1)OC(CCNC(C)=O)CO2	10.1021/jm980026p
	15838841	37018	1	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	280	6	2	4	1.5	CCCNC(=O)NCCOc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL139087	37018	1	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	280	6	2	4	1.5	CCCNC(=O)NCCOc1cccc2c1OCCO2	10.1021/jm980026p
	25014882	194474	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	302	5	2	4	2.7	COC(=O)Nc1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL495232	194474	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	302	5	2	4	2.7	COC(=O)Nc1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1016/j.bmc.2008.03.036
	17957000	68179	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	286	4	2	3	2.7	COC(=O)Nc1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	CHEMBL1770214	68179	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	286	4	2	3	2.7	COC(=O)Nc1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	1357	9263	139	None	-1	9	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT1 (unknown origin)Binding affinity to melatonin receptor MT1 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	1672	9263	139	None	-1	9	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT1 (unknown origin)Binding affinity to melatonin receptor MT1 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	224	9263	139	None	-1	9	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT1 (unknown origin)Binding affinity to melatonin receptor MT1 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	896	9263	139	None	-1	9	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT1 (unknown origin)Binding affinity to melatonin receptor MT1 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	CHEMBL45	9263	139	None	-1	9	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT1 (unknown origin)Binding affinity to melatonin receptor MT1 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	DB01065	9263	139	None	-1	9	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT1 (unknown origin)Binding affinity to melatonin receptor MT1 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	10440	9458	20	None	-21	3	Human	5.2	pKd	=	5.2	Binding	Agonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	139030523	9458	20	None	-21	3	Human	5.2	pKd	=	5.2	Binding	Agonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	CHEMBL4449712	9458	20	None	-21	3	Human	5.2	pKd	=	5.2	Binding	Agonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	9903515	29565	0	None	9	2	Human	11.0	pKi	=	11	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	3	1	2	3.0	COc1ccc2cccc3c2c1C(CNC(C)=O)CC3	10.1021/jm000922c
	CHEMBL132802	29565	0	None	9	2	Human	11.0	pKi	=	11	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	3	1	2	3.0	COc1ccc2cccc3c2c1C(CNC(C)=O)CC3	10.1021/jm000922c
	9839629	106892	0	None	1	2	Human	11.0	pKi	=	11	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL287560	106892	0	None	1	2	Human	11.0	pKi	=	11	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	10925712	119357	0	None	1	2	Human	11.0	pKi	=	11	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	7	1	3	4.3	C=CCC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL330137	119357	0	None	1	2	Human	11.0	pKi	=	11	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	7	1	3	4.3	C=CCC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	9839629	106892	0	None	1	2	Human	11.0	pKi	=	11	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 mins	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.5b00982
	CHEMBL287560	106892	0	None	1	2	Human	11.0	pKi	=	11	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 mins	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.5b00982
	9796846	123214	0	None	12	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	313	5	1	3	3.4	CCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL336054	123214	0	None	12	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	313	5	1	3	3.4	CCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	53237947	68789	0	None	-1	2	Human	10.9	pKi	=	10.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	299	5	1	2	3.5	CCC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774514	68789	0	None	-1	2	Human	10.9	pKi	=	10.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	299	5	1	2	3.5	CCC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	115348	6858	47	None	4	2	Human	10.9	pKi	=	10.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm011053+
	1343	6858	47	None	4	2	Human	10.9	pKi	=	10.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm011053+
	CHEMBL289233	6858	47	None	4	2	Human	10.9	pKi	=	10.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm011053+
	DB08190	6858	47	None	4	2	Human	10.9	pKi	=	10.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm011053+
	1356	10061	99	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
	208902	10061	99	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
	2355	10061	99	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
	CHEMBL1218	10061	99	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
	DB00980	10061	99	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
	1356	10061	99	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity to human MT1 expressed in CHO cellsBinding affinity to human MT1 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
	208902	10061	99	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity to human MT1 expressed in CHO cellsBinding affinity to human MT1 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
	2355	10061	99	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity to human MT1 expressed in CHO cellsBinding affinity to human MT1 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
	CHEMBL1218	10061	99	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity to human MT1 expressed in CHO cellsBinding affinity to human MT1 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
	DB00980	10061	99	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity to human MT1 expressed in CHO cellsBinding affinity to human MT1 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
	9926304	123353	0	None	9	2	Human	10.8	pKi	=	10.8	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	299	4	1	3	3.0	COc1ccc2ccc(OC)c3c2c1CCC3CNC(C)=O	10.1021/jm000922c
	CHEMBL336509	123353	0	None	9	2	Human	10.8	pKi	=	10.8	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	299	4	1	3	3.0	COc1ccc2ccc(OC)c3c2c1CCC3CNC(C)=O	10.1021/jm000922c
	9797460	124931	0	None	6	2	Human	10.8	pKi	=	10.8	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	327	6	1	3	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL340832	124931	0	None	6	2	Human	10.8	pKi	=	10.8	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	327	6	1	3	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	11723593	113655	0	None	-1	2	Human	10.7	pKi	=	10.7	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	321	6	1	3	4.0	C=CC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL314512	113655	0	None	-1	2	Human	10.7	pKi	=	10.7	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	321	6	1	3	4.0	C=CC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	53237946	68788	0	None	-1	2	Human	10.6	pKi	=	10.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	285	4	1	2	3.1	CC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774513	68788	0	None	-1	2	Human	10.6	pKi	=	10.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	285	4	1	2	3.1	CC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	9840277	30335	0	None	10	2	Human	10.6	pKi	=	10.6	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	325	5	1	3	3.4	COc1ccc2ccc(OC)c3c2c1CCC3CNC(=O)C1CC1	10.1021/jm000922c
	CHEMBL133416	30335	0	None	10	2	Human	10.6	pKi	=	10.6	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	325	5	1	3	3.4	COc1ccc2ccc(OC)c3c2c1CCC3CNC(=O)C1CC1	10.1021/jm000922c
	53310841	70571	0	None	5	2	Human	10.6	pKi	=	10.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	299	5	1	4	2.2	CCC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802028	70571	0	None	5	2	Human	10.6	pKi	=	10.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	299	5	1	4	2.2	CCC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	164621472	192674	0	None	2	2	Human	10.6	pKi	=	10.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	288	4	1	3	3.6	CCC(=O)NCCC1CCc2ccc3nc(C)sc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4868554	192674	0	None	2	2	Human	10.6	pKi	=	10.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	288	4	1	3	3.6	CCC(=O)NCCC1CCc2ccc3nc(C)sc3c21	10.1021/acs.jmedchem.0c01836
	9873402	42613	0	None	1	2	Human	10.5	pKi	=	10.5	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	596	19	2	4	7.9	CC(=O)NCCc1cccc2ccc(OCCCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	CHEMBL14417	42613	0	None	1	2	Human	10.5	pKi	=	10.5	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	596	19	2	4	7.9	CC(=O)NCCc1cccc2ccc(OCCCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	18466111	26617	0	None	1	2	Human	10.5	pKi	=	10.5	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL130214	26617	0	None	1	2	Human	10.5	pKi	=	10.5	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	122188346	129940	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	262	4	1	3	2.0	CCC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612603	129940	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	262	4	1	3	2.0	CCC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	71533431	6866	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	10.1016/j.bmcl.2012.11.069
	7775	6866	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	10.1016/j.bmcl.2012.11.069
	CHEMBL2314259	6866	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	10.1016/j.bmcl.2012.11.069
	57781216	132625	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648356	132625	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	53237949	68791	0	None	-3	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	4	1	2	3.7	CC(C)C1=C(CCNC(=O)C(F)(F)F)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
	CHEMBL1774516	68791	0	None	-3	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	4	1	2	3.7	CC(C)C1=C(CCNC(=O)C(F)(F)F)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
	23725567	132631	0	None	2	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	3	1	3	3.2	CC(=O)NCCC1CCc2ccc3nc(C)sc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648362	132631	0	None	2	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	3	1	3	3.2	CC(=O)NCCC1CCc2ccc3nc(C)sc3c21	10.1021/acs.jmedchem.0c01836
	24954990	70569	0	None	5	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	287	5	1	4	1.9	CCC(=O)NCCc1c(CC)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802026	70569	0	None	5	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	287	5	1	4	1.9	CCC(=O)NCCc1c(CC)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	10925379	214344	0	None	1	2	Human	10.4	pKi	=	10.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	324	5	2	3	3.6	CNC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL94838	214344	0	None	1	2	Human	10.4	pKi	=	10.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	324	5	2	3	3.6	CNC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	56659223	71763	0	None	5	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	2	3	2.9	COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2011.06.030
	CHEMBL1823015	71763	0	None	5	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	2	3	2.9	COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2011.06.030
	127042142	144853	0	None	3	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	310	5	1	4	3.2	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3765540	144853	0	None	3	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	310	5	1	4	3.2	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	71533430	93189	0	None	-1	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	241	3	1	2	3.0	COc1ccc2cccc(/C=C/NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
	CHEMBL2314255	93189	0	None	-1	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	241	3	1	2	3.0	COc1ccc2cccc(/C=C/NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
	53310840	70570	0	None	6	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	285	4	1	4	1.8	CC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802027	70570	0	None	6	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	285	4	1	4	1.8	CC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	22004791	68787	0	None	-2	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	243	3	1	2	2.1	CC(=O)NCCC1=CCc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774512	68787	0	None	-2	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	243	3	1	2	2.1	CC(=O)NCCC1=CCc2ccc3c(c21)CCO3	10.1021/jm200221q
	9916005	39486	0	None	3	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	568	17	2	4	7.1	CC(=O)NCCc1cccc2ccc(OCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	CHEMBL14136	39486	0	None	3	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	568	17	2	4	7.1	CC(=O)NCCc1cccc2ccc(OCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	9914839	104932	0	None	34	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	526	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	CHEMBL273787	104932	0	None	34	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	526	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	44264903	212397	0	None	4	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	270	4	1	3	3.4	COc1cccc(N(C)c2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL8168	212397	0	None	4	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	270	4	1	3	3.4	COc1cccc(N(C)c2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
	44272316	74374	0	None	4	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	392	10	2	3	5.3	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL19026	74374	0	None	4	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	392	10	2	3	5.3	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2	10.1016/j.bmcl.2003.12.052
	10452167	85564	0	None	1	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	376	9	1	3	5.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2003.12.052
	CHEMBL2112690	85564	0	None	1	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	376	9	1	3	5.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2003.12.052
	9998754	85569	0	None	7	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	362	8	1	3	4.6	CC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2003.12.052
	CHEMBL2112700	85569	0	None	7	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	362	8	1	3	4.6	CC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2003.12.052
	10446712	85573	0	None	6	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	286	6	1	3	3.4	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12	10.1016/j.bmcl.2003.12.052
	CHEMBL2112722	85573	0	None	6	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	286	6	1	3	3.4	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12	10.1016/j.bmcl.2003.12.052
	10016733	85574	0	None	3	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	284	5	1	3	3.0	CCc1nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2003.12.052
	CHEMBL2112724	85574	0	None	3	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	284	5	1	3	3.0	CCc1nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2003.12.052
	10423378	85575	0	None	8	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	272	5	1	3	3.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12	10.1016/j.bmcl.2003.12.052
	CHEMBL2112727	85575	0	None	8	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	272	5	1	3	3.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12	10.1016/j.bmcl.2003.12.052
	11741001	85579	0	None	9	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	388	9	1	3	5.0	O=C(NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2003.12.052
	CHEMBL2112734	85579	0	None	9	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	388	9	1	3	5.0	O=C(NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2003.12.052
	57381112	8198	0	None	20	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
	7776	8198	0	None	20	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
	CHEMBL1946221	8198	0	None	20	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
	57381112	8198	0	None	20	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
	7776	8198	0	None	20	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
	CHEMBL1946221	8198	0	None	20	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
	9798080	26257	0	None	3	2	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	341	7	1	3	4.2	CCCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL129890	26257	0	None	3	2	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	341	7	1	3	4.2	CCCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	53238407	68799	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1cccc(C2=C(CCNC(C)=O)c3c(ccc4c3CCO4)C2)c1	10.1021/jm200221q
	CHEMBL1774526	68799	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1cccc(C2=C(CCNC(C)=O)c3c(ccc4c3CCO4)C2)c1	10.1021/jm200221q
	198	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	82148	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	99	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	CHEMBL10878	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	DB06594	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	198	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	82148	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	99	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	CHEMBL10878	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	DB06594	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	15453090	93187	0	None	3	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	285	4	1	3	2.8	COc1ccc2ccc(OC)c([C@@H]3C[C@H]3NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
	CHEMBL2314253	93187	0	None	3	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	285	4	1	3	2.8	COc1ccc2ccc(OC)c([C@@H]3C[C@H]3NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
	24954989	8314	1	None	6	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	7774	8314	1	None	6	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	CHEMBL1802025	8314	1	None	6	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	23725565	132624	0	None	1	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCCC1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648355	132624	0	None	1	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCCC1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	23725514	132627	0	None	1	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	272	4	1	3	3.1	CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648358	132627	0	None	1	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	272	4	1	3	3.1	CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	115348	6858	47	None	4	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm401343c
	1343	6858	47	None	4	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm401343c
	CHEMBL289233	6858	47	None	4	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm401343c
	DB08190	6858	47	None	4	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm401343c
	53238185	68797	0	None	-2	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	320	4	1	3	3.0	CC(=O)NCCC1=C(c2cccnc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774524	68797	0	None	-2	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	320	4	1	3	3.0	CC(=O)NCCC1=C(c2cccnc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	9883864	123432	0	None	7	2	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	327	6	1	3	3.8	CCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL337024	123432	0	None	7	2	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	327	6	1	3	3.8	CCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	46888521	15416	0	None	26	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	499	12	1	5	5.6	COC(=O)Cc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095196	15416	0	None	26	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	499	12	1	5	5.6	COC(=O)Cc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	1351	9174	21	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Binding affinity to MT1 receptor (unknown origin)Binding affinity to MT1 receptor (unknown origin)	ChEMBL	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	10.1039/C4MD00149D
	219018	9174	21	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Binding affinity to MT1 receptor (unknown origin)Binding affinity to MT1 receptor (unknown origin)	ChEMBL	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	10.1039/C4MD00149D
	CHEMBL4079759	9174	21	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Binding affinity to MT1 receptor (unknown origin)Binding affinity to MT1 receptor (unknown origin)	ChEMBL	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	10.1039/C4MD00149D
	9893513	37734	0	None	29	2	Human	10.1	pKi	=	10.1	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	540	15	2	4	6.4	CC(=O)NCCc1cccc2ccc(OCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	CHEMBL13985	37734	0	None	29	2	Human	10.1	pKi	=	10.1	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	540	15	2	4	6.4	CC(=O)NCCc1cccc2ccc(OCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	115348	6858	47	None	4	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1016/S0960-894X(97)00444-7
	1343	6858	47	None	4	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1016/S0960-894X(97)00444-7
	CHEMBL289233	6858	47	None	4	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1016/S0960-894X(97)00444-7
	DB08190	6858	47	None	4	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1016/S0960-894X(97)00444-7
	11100761	108568	4	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	372	4	1	3	2.5	COc1ccc2c(c1)c(CCNC(C)=O)c(I)n2C	10.1021/jm011053+
	CHEMBL300056	108568	4	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	372	4	1	3	2.5	COc1ccc2c(c1)c(CCNC(C)=O)c(I)n2C	10.1021/jm011053+
	1357	9263	139	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
	1672	9263	139	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
	224	9263	139	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
	896	9263	139	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
	CHEMBL45	9263	139	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
	DB01065	9263	139	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
	24955343	70566	0	None	1	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	321	4	1	4	2.6	CC(=O)NCCc1c(-c2ccccc2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802022	70566	0	None	1	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	321	4	1	4	2.6	CC(=O)NCCc1c(-c2ccccc2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	1357	9263	139	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
	1672	9263	139	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
	224	9263	139	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
	896	9263	139	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
	CHEMBL45	9263	139	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
	DB01065	9263	139	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
	53310839	70568	0	None	2	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.6	CCC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802024	70568	0	None	2	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.6	CCC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	10163052	15293	0	None	72	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	483	12	2	4	5.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1094212	15293	0	None	72	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	483	12	2	4	5.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12	10.1016/j.bmc.2010.04.008
	1357	9263	139	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1672	9263	139	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	224	9263	139	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	896	9263	139	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	CHEMBL45	9263	139	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	DB01065	9263	139	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1357	9263	139	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
	1672	9263	139	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
	224	9263	139	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
	896	9263	139	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
	CHEMBL45	9263	139	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
	DB01065	9263	139	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
	10016919	107386	1	None	3	2	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	287	6	1	3	2.9	CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL291857	107386	1	None	3	2	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	287	6	1	3	2.9	CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	10016919	107386	1	None	3	2	Human	10.0	pKi	=	10	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	287	6	1	3	2.9	CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12	10.1021/jm970437q
	CHEMBL291857	107386	1	None	3	2	Human	10.0	pKi	=	10	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	287	6	1	3	2.9	CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12	10.1021/jm970437q
	10659603	27028	0	None	-1	2	Human	10.0	pKi	=	10	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	4	1	2	3.0	CCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL130542	27028	0	None	-1	2	Human	10.0	pKi	=	10	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	4	1	2	3.0	CCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	9925797	29024	0	None	3	2	Human	10.0	pKi	=	10	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	COc1ccc2cccc3c2c1C(CCNC(C)=O)CC3	10.1021/jm000922c
	CHEMBL132340	29024	0	None	3	2	Human	10.0	pKi	=	10	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	COc1ccc2cccc3c2c1C(CCNC(C)=O)CC3	10.1021/jm000922c
	198	7101	126	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	82148	7101	126	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	99	7101	126	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	CHEMBL10878	7101	126	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	DB06594	7101	126	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	145982070	173254	0	None	1	2	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	283	3	1	2	3.2	COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4278248	173254	0	None	1	2	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	283	3	1	2	3.2	COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	198	7101	126	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	82148	7101	126	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	99	7101	126	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	CHEMBL10878	7101	126	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	DB06594	7101	126	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	198	7101	126	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
	82148	7101	126	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
	99	7101	126	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
	CHEMBL10878	7101	126	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
	DB06594	7101	126	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
	71540389	93190	0	None	-1	2	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	241	3	1	2	3.0	COc1ccc2ccccc2c1/C=C/NC(C)=O	10.1016/j.bmcl.2012.11.069
	CHEMBL2314257	93190	0	None	-1	2	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	241	3	1	2	3.0	COc1ccc2ccccc2c1/C=C/NC(C)=O	10.1016/j.bmcl.2012.11.069
	9839199	28135	0	None	-1	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	CHEMBL131424	28135	0	None	-1	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	53237948	68790	0	None	-3	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	311	5	1	2	3.5	CC(C)C1=C(CCNC(=O)C2CC2)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
	CHEMBL1774515	68790	0	None	-3	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	311	5	1	2	3.5	CC(C)C1=C(CCNC(=O)C2CC2)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
	1357	9263	139	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	1672	9263	139	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	224	9263	139	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	896	9263	139	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	CHEMBL45	9263	139	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	DB01065	9263	139	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	10562968	26967	0	None	1	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	255	3	1	2	2.6	COc1ccc2cccc3c2c1C(CNC(C)=O)C3	10.1021/jm000922c
	CHEMBL130490	26967	0	None	1	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	255	3	1	2	2.6	COc1ccc2cccc3c2c1C(CNC(C)=O)C3	10.1021/jm000922c
	1357	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	1672	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	224	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	896	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	CHEMBL45	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	DB01065	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	198	7101	126	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	82148	7101	126	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	99	7101	126	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	CHEMBL10878	7101	126	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	DB06594	7101	126	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	1357	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
	1672	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
	224	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
	896	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
	CHEMBL45	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
	DB01065	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
	198	7101	126	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	82148	7101	126	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	99	7101	126	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	CHEMBL10878	7101	126	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	DB06594	7101	126	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	1357	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
	1672	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
	224	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
	896	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
	CHEMBL45	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
	DB01065	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
	198	7101	126	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	82148	7101	126	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	99	7101	126	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	CHEMBL10878	7101	126	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	DB06594	7101	126	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	1357	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
	1672	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
	224	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
	896	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
	CHEMBL45	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
	DB01065	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
	44272305	74097	0	None	14	2	Human	9.9	pKi	=	9.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	392	9	2	3	5.1	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL18845	74097	0	None	14	2	Human	9.9	pKi	=	9.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	392	9	2	3	5.1	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2	10.1016/j.bmcl.2003.12.052
	44358146	33850	0	None	2	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	4	1	3	2.1	CCCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL136531	33850	0	None	2	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	4	1	3	2.1	CCCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	1357	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	1672	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	224	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	896	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	CHEMBL45	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	DB01065	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	1357	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	1672	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	224	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	896	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	CHEMBL45	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	DB01065	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	1357	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
	1672	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
	224	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
	896	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
	CHEMBL45	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
	DB01065	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
	1357	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
	1672	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
	224	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
	896	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
	CHEMBL45	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
	DB01065	9263	139	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
	10059864	116600	5	None	2	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL323332	116600	5	None	2	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm0005252
	56653119	178571	0	None	1	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	322	7	2	2	3.5	CC(=O)NCCc1c[nH]c2ccc(OCCc3ccccc3)cc12	10.1016/j.ejmech.2019.111847
	CHEMBL4467954	178571	0	None	1	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	322	7	2	2	3.5	CC(=O)NCCc1c[nH]c2ccc(OCCc3ccccc3)cc12	10.1016/j.ejmech.2019.111847
	10059864	116600	5	None	2	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL323332	116600	5	None	2	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.ejmech.2015.12.047
	10059864	116600	5	None	2	2	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.ejmech.2016.01.008
	CHEMBL323332	116600	5	None	2	2	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.ejmech.2016.01.008
	24954991	70567	0	None	3	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	259	3	1	4	1.3	CC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802023	70567	0	None	3	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	259	3	1	4	1.3	CC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	1357	9263	139	None	-1	9	Human	9.8	pKi	=	9.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
	1672	9263	139	None	-1	9	Human	9.8	pKi	=	9.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
	224	9263	139	None	-1	9	Human	9.8	pKi	=	9.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
	896	9263	139	None	-1	9	Human	9.8	pKi	=	9.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
	CHEMBL45	9263	139	None	-1	9	Human	9.8	pKi	=	9.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
	DB01065	9263	139	None	-1	9	Human	9.8	pKi	=	9.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
	25025104	193094	0	None	5	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	4	1	3	2.6	CCC(=O)NCCC1CCc2ccn3nc(C)cc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4874630	193094	0	None	5	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	4	1	3	2.6	CCC(=O)NCCC1CCc2ccn3nc(C)cc3c21	10.1021/acs.jmedchem.0c01836
	44358196	126064	0	None	2	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	260	3	1	3	1.7	CCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL343825	126064	0	None	2	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	260	3	1	3	1.7	CCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	198	7101	126	None	-1	6	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
	82148	7101	126	None	-1	6	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
	99	7101	126	None	-1	6	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
	CHEMBL10878	7101	126	None	-1	6	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
	DB06594	7101	126	None	-1	6	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
	44272317	105689	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	300	6	2	3	3.2	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL279343	105689	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	300	6	2	3	3.2	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1	10.1016/j.bmcl.2003.12.052
	1357	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	1672	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	224	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	896	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	CHEMBL45	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	DB01065	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	9817262	26256	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	CCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	CHEMBL129889	26256	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	CCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	1357	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
	1672	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
	224	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
	896	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
	CHEMBL45	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
	DB01065	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
	9948714	27476	0	None	2	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	313	5	1	3	3.4	COc1ccc2ccc(OC)c3c2c1CCC3CCNC(C)=O	10.1021/jm000922c
	CHEMBL130898	27476	0	None	2	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	313	5	1	3	3.4	COc1ccc2ccc(OC)c3c2c1CCC3CCNC(C)=O	10.1021/jm000922c
	44272422	174658	0	None	3	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	288	5	2	3	3.1	CCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL431103	174658	0	None	3	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	288	5	2	3	3.1	CCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1	10.1016/j.bmcl.2003.12.052
	21581654	67526	1	None	1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760944	67526	1	None	1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	1357	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
	1672	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
	224	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
	896	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
	CHEMBL45	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
	DB01065	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
	1357	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
	1672	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
	224	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
	896	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
	CHEMBL45	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
	DB01065	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
	59145922	193051	0	None	7	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	257	3	1	3	2.2	CC(=O)NCCC1CCc2ccn3nc(C)cc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4874010	193051	0	None	7	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	257	3	1	3	2.2	CC(=O)NCCC1CCc2ccn3nc(C)cc3c21	10.1021/acs.jmedchem.0c01836
	127042442	144689	0	None	-6	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	328	5	1	4	3.3	COc1ccc2oc(-c3ccc(F)cc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3763503	144689	0	None	-6	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	328	5	1	4	3.3	COc1ccc2oc(-c3ccc(F)cc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	127042791	144838	0	None	-2	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	4	1	4	2.1	COc1ccc2oc(I)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3765401	144838	0	None	-2	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	4	1	4	2.1	COc1ccc2oc(I)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	1357	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
	1672	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
	224	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
	896	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
	CHEMBL45	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
	DB01065	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
	71540396	93192	0	None	1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	286	4	2	3	2.8	CNC(=O)N/C=C/c1c(OC)ccc2ccc(OC)cc12	10.1016/j.bmcl.2012.11.069
	CHEMBL2314260	93192	0	None	1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	286	4	2	3	2.8	CNC(=O)N/C=C/c1c(OC)ccc2ccc(OC)cc12	10.1016/j.bmcl.2012.11.069
	1357	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1672	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	224	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	896	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	CHEMBL45	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	DB01065	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1357	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
	1672	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
	224	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
	896	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
	CHEMBL45	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
	DB01065	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
	10540964	123406	0	None	1	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL336858	123406	0	None	1	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	44272320	105378	0	None	-2	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	288	6	2	3	3.2	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)CC)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL276921	105378	0	None	-2	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	288	6	2	3	3.2	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)CC)c2O1	10.1016/j.bmcl.2003.12.052
	1357	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
	1672	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
	224	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
	896	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
	CHEMBL45	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
	DB01065	9263	139	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
	23725515	132634	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	272	4	1	3	2.9	CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	10.1021/acs.jmedchem.0c01836
	CHEMBL3648365	132634	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	272	4	1	3	2.9	CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	10.1021/acs.jmedchem.0c01836
	1357	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
	1672	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
	224	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
	896	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
	CHEMBL45	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
	DB01065	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
	1357	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	1672	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	224	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	896	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	CHEMBL45	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	DB01065	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	21581654	67526	1	None	1	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2011.06.030
	CHEMBL1760944	67526	1	None	1	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2011.06.030
	1357	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	1672	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	224	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	896	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	CHEMBL45	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	DB01065	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	1357	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	1672	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	224	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	896	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	CHEMBL45	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	DB01065	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	21581654	67526	1	None	1	2	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL1760944	67526	1	None	1	2	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	1357	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	1672	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	224	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	896	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	CHEMBL45	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	DB01065	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	1357	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
	1672	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
	224	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
	896	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
	CHEMBL45	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
	DB01065	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
	1357	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
	1672	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
	224	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
	896	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
	CHEMBL45	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
	DB01065	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
	18360631	15487	0	None	26	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	516	13	2	4	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4c(c3)C(CCNC(C)=O)CCC4)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095831	15487	0	None	26	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	516	13	2	4	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4c(c3)C(CCNC(C)=O)CCC4)cc12	10.1016/j.bmc.2010.04.008
	1357	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
	1672	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
	224	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
	896	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
	CHEMBL45	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
	DB01065	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
	1357	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
	1672	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
	224	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
	896	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
	CHEMBL45	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
	DB01065	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
	1357	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
	1672	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
	224	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
	896	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
	CHEMBL45	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
	DB01065	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
	1357	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	1672	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	224	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	896	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	CHEMBL45	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	DB01065	9263	139	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	1357	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
	1672	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
	224	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
	896	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
	CHEMBL45	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
	DB01065	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
	1357	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
	1672	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
	224	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
	896	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
	CHEMBL45	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
	DB01065	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
	1357	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
	1672	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
	224	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
	896	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
	CHEMBL45	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
	DB01065	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
	1357	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970721h
	1672	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970721h
	224	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970721h
	896	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970721h
	CHEMBL45	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970721h
	DB01065	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970721h
	1357	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
	1672	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
	224	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
	896	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
	CHEMBL45	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
	DB01065	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
	1357	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
	1672	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
	224	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
	896	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
	CHEMBL45	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
	DB01065	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
	1357	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
	1672	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
	224	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
	896	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
	CHEMBL45	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
	DB01065	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
	145981162	173276	0	None	-3	3	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	270	3	2	2	2.5	COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4278575	173276	0	None	-3	3	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	270	3	2	2	2.5	COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3	10.1016/j.ejmech.2017.10.025
	145986532	174060	0	None	-1	3	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	269	3	1	2	3.0	COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4293386	174060	0	None	-1	3	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	269	3	1	2	3.0	COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	137660333	166299	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1ccc2cccc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4102177	166299	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1ccc2cccc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.12.013
	25024912	192698	0	None	1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	4	1	3	2.5	CCC(=O)NCCC1CCc2ccc3nn(C)cc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4869029	192698	0	None	1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	4	1	3	2.5	CCC(=O)NCCC1CCc2ccc3nn(C)cc3c21	10.1021/acs.jmedchem.0c01836
	15453084	93185	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	255	3	1	2	2.8	COc1ccc2cccc([C@@H]3C[C@H]3NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
	CHEMBL2314251	93185	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	255	3	1	2	2.8	COc1ccc2cccc([C@@H]3C[C@H]3NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
	11079938	200636	4	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	403	5	2	4	2.4	COc1cc2c(CCNC(C)=O)c(I)[nH]c2cc1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL52755	200636	4	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	403	5	2	4	2.4	COc1cc2c(CCNC(C)=O)c(I)[nH]c2cc1[N+](=O)[O-]	10.1021/jm011053+
	1357	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
	1672	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
	224	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
	896	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
	CHEMBL45	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
	DB01065	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
	1357	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jnatprod.7b00853
	1672	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jnatprod.7b00853
	224	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jnatprod.7b00853
	896	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jnatprod.7b00853
	CHEMBL45	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jnatprod.7b00853
	DB01065	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jnatprod.7b00853
	53310987	70573	0	None	1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	327	4	1	4	2.4	CCC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802030	70573	0	None	1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	327	4	1	4	2.4	CCC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	1357	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
	1672	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
	224	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
	896	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
	CHEMBL45	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
	DB01065	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
	1357	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
	1672	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
	224	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
	896	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
	CHEMBL45	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
	DB01065	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
	139451781	191637	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4852440	191637	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	1357	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	1672	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	224	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	896	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	CHEMBL45	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	DB01065	9263	139	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	44272440	74300	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	260	4	2	3	2.5	CCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL18960	74300	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	260	4	2	3	2.5	CCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1	10.1016/j.bmcl.2003.12.052
	59145872	192955	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	257	3	1	3	2.1	CC(=O)NCCC1CCc2ccc3nn(C)cc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4872592	192955	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	257	3	1	3	2.1	CC(=O)NCCC1CCc2ccc3nn(C)cc3c21	10.1021/acs.jmedchem.0c01836
	18466111	26617	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL130214	26617	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	10661735	175103	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	6	1	2	3.8	CCCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL434226	175103	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	6	1	2	3.8	CCCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	46888522	15417	0	None	11	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	513	12	1	5	6.2	COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1	10.1016/j.bmc.2010.04.008
	CHEMBL1095197	15417	0	None	11	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	513	12	1	5	6.2	COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1	10.1016/j.bmc.2010.04.008
	1357	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptorDisplacement of [125I]2-iodomelatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm2006782
	1672	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptorDisplacement of [125I]2-iodomelatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm2006782
	224	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptorDisplacement of [125I]2-iodomelatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm2006782
	896	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptorDisplacement of [125I]2-iodomelatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm2006782
	CHEMBL45	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptorDisplacement of [125I]2-iodomelatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm2006782
	DB01065	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptorDisplacement of [125I]2-iodomelatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm2006782
	1357	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
	1672	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
	224	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
	896	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
	CHEMBL45	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
	DB01065	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
	139451763	193112	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	305	8	1	5	2.4	CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21	10.1021/acs.jmedchem.0c00627
	CHEMBL4874954	193112	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	305	8	1	5	2.4	CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21	10.1021/acs.jmedchem.0c00627
	44317845	212285	0	None	3	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	301	7	1	3	3.3	CCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
	CHEMBL80736	212285	0	None	3	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	301	7	1	3	3.3	CCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
	1357	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
	1672	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
	224	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
	896	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
	CHEMBL45	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
	DB01065	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
	57781246	132635	0	None	-2	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	284	4	1	3	3.3	CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648366	132635	0	None	-2	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	284	4	1	3	3.3	CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21	10.1021/acs.jmedchem.0c01836
	1357	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
	1672	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
	224	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
	896	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
	CHEMBL45	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
	DB01065	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
	1357	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
	1672	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
	224	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
	896	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
	CHEMBL45	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
	DB01065	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
	1357	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
	1672	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
	224	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
	896	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
	CHEMBL45	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
	DB01065	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
	145982333	173336	0	None	1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4279639	173336	0	None	1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145981769	173446	0	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	270	3	1	3	2.4	COc1ccc2ccc3c(c2n1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4281712	173446	0	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	270	3	1	3	2.4	COc1ccc2ccc3c(c2n1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	10778397	26607	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	4	1	2	3.0	COc1ccc2cccc3c2c1C(CCNC(C)=O)C3	10.1021/jm000922c
	CHEMBL130203	26607	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	4	1	2	3.0	COc1ccc2cccc3c2c1C(CCNC(C)=O)C3	10.1021/jm000922c
	139451795	192108	0	None	2	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859677	192108	0	None	2	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	9839199	28135	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	CHEMBL131424	28135	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	57781227	132623	0	None	-6	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	244	3	1	3	2.4	CC(=O)NCCC1CCc2ccc3ncoc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648354	132623	0	None	-6	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	244	3	1	3	2.4	CC(=O)NCCC1CCc2ccc3ncoc3c21	10.1021/acs.jmedchem.0c01836
	23725612	132636	0	None	-2	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	4	1	4	2.4	COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	10.1021/acs.jmedchem.0c01836
	CHEMBL3648367	132636	0	None	-2	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	4	1	4	2.4	COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	10.1021/acs.jmedchem.0c01836
	1357	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
	1672	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
	224	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
	896	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
	CHEMBL45	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
	DB01065	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
	1357	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	1672	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	224	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	896	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	CHEMBL45	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	DB01065	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	1357	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
	1672	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
	224	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
	896	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
	CHEMBL45	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
	DB01065	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
	1357	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
	1672	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
	224	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
	896	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
	CHEMBL45	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
	DB01065	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
	1357	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1672	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	224	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	896	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	CHEMBL45	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	DB01065	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	24954992	70572	0	None	1	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	313	3	1	4	2.0	CC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802029	70572	0	None	1	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	313	3	1	4	2.0	CC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	1362	10210	22	None	39	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
	9870523	10210	22	None	39	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
	CHEMBL429392	10210	22	None	39	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
	1362	10210	22	None	39	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	9870523	10210	22	None	39	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	CHEMBL429392	10210	22	None	39	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	1362	10210	22	None	39	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	9870523	10210	22	None	39	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	CHEMBL429392	10210	22	None	39	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	1357	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
	1672	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
	224	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
	896	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
	CHEMBL45	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
	DB01065	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
	1357	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
	1672	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
	224	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
	896	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
	CHEMBL45	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
	DB01065	9263	139	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
	7778	7601	0	None	97	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
	9957516	7601	0	None	97	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
	CHEMBL1094546	7601	0	None	97	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
	1355	10211	5	None	70	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
	9806449	10211	5	None	70	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
	CHEMBL14453	10211	5	None	70	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
	1355	10211	5	None	70	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	9806449	10211	5	None	70	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	CHEMBL14453	10211	5	None	70	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	44272425	74101	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	300	5	2	3	3.1	CC(C)C1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL18846	74101	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	300	5	2	3	3.1	CC(C)C1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1	10.1016/j.bmcl.2003.12.052
	1355	10211	5	None	70	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	9806449	10211	5	None	70	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	CHEMBL14453	10211	5	None	70	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	145982333	173336	0	None	1	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4279639	173336	0	None	1	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145993188	173801	0	None	-3	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	319	4	1	3	2.6	COc1ccc2ccc3c(c2c1)C(C)(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4288497	173801	0	None	-3	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	319	4	1	3	2.6	COc1ccc2ccc3c(c2c1)C(C)(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	145988741	174015	0	None	-6	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	299	5	1	3	2.6	COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4292336	174015	0	None	-6	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	299	5	1	3	2.6	COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	1355	10211	5	None	70	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	9806449	10211	5	None	70	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	CHEMBL14453	10211	5	None	70	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	137647756	164723	0	None	-6	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	259	4	2	3	1.7	CNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4084612	164723	0	None	-6	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	259	4	2	3	1.7	CNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	139451764	193046	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4873903	193046	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	44349100	121589	0	None	34	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	376	10	1	3	4.9	O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2004.04.082
	CHEMBL334079	121589	0	None	34	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	376	10	1	3	4.9	O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2004.04.082
	44349100	121589	0	None	34	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	376	10	1	3	4.9	O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1021/jm401343c
	CHEMBL334079	121589	0	None	34	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	376	10	1	3	4.9	O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1021/jm401343c
	46888492	15615	0	None	18	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	564	14	2	5	6.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)c5ccco5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1096991	15615	0	None	18	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	564	14	2	5	6.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)c5ccco5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	10468642	33891	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	275	3	2	3	1.5	CCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL136564	33891	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	275	3	2	3	1.5	CCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	10640828	28254	0	None	2	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	339	6	1	3	3.8	COc1ccc2ccc(OC)c3c2c1CCC3CCNC(=O)C1CC1	10.1021/jm000922c
	CHEMBL131575	28254	0	None	2	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	339	6	1	3	3.8	COc1ccc2ccc(OC)c3c2c1CCC3CCNC(=O)C1CC1	10.1021/jm000922c
	1357	9263	139	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
	1672	9263	139	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
	224	9263	139	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
	896	9263	139	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
	CHEMBL45	9263	139	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
	DB01065	9263	139	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
	1357	9263	139	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1672	9263	139	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	224	9263	139	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	896	9263	139	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	CHEMBL45	9263	139	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	DB01065	9263	139	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	10400294	25321	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	258	5	1	3	2.6	Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL127570	25321	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	258	5	1	3	2.6	Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	122188347	129941	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	232	3	1	2	2.0	CCC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612604	129941	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	232	3	1	2	2.0	CCC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	139451780	192723	0	None	5	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	303	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1	10.1021/acs.jmedchem.0c00627
	CHEMBL4869463	192723	0	None	5	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	303	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1	10.1021/acs.jmedchem.0c00627
	46935150	22651	0	None	6	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(O[C@@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223130	22651	0	None	6	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(O[C@@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	9884406	214405	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	341	6	1	3	3.9	COc1ccc2oc(Cc3cccc(F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL95166	214405	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	341	6	1	3	3.9	COc1ccc2oc(Cc3cccc(F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	10361427	119648	0	None	18	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	364	10	1	3	4.9	CCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL330969	119648	0	None	18	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	364	10	1	3	4.9	CCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	12324	10683	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	10.1021/acs.jmedchem.8b00893
	145966622	10683	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	10.1021/acs.jmedchem.8b00893
	CHEMBL4210086	10683	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	10.1021/acs.jmedchem.8b00893
	10515048	123589	0	None	-8	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	253	4	1	1	3.4	CCCC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL337882	123589	0	None	-8	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	253	4	1	1	3.4	CCCC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	46888520	15415	0	None	10	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	538	15	2	4	6.1	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095195	15415	0	None	10	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	538	15	2	4	6.1	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	10199282	123371	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	3	1	2	3.0	COc1ccc2cccc3c2c1CCC3CNC(C)=O	10.1021/jm000922c
	CHEMBL336647	123371	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	3	1	2	3.0	COc1ccc2cccc3c2c1CCC3CNC(C)=O	10.1021/jm000922c
	145982167	173390	0	None	-7	3	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	305	4	1	3	2.4	COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4280601	173390	0	None	-7	3	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	305	4	1	3	2.4	COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	145990662	173708	0	None	-2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	312	4	2	2	3.4	CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4286896	173708	0	None	-2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	312	4	2	2	3.4	CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137636213	162865	0	None	-8	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4062947	162865	0	None	-8	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	24750192	10689	13	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	10.1021/jm700957j
	7777	10689	13	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	10.1021/jm700957j
	CHEMBL237236	10689	13	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	10.1021/jm700957j
	24750193	95328	1	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	236	6	1	3	1.7	COc1cccc(N(C)CCCNC(C)=O)c1	10.1021/jm700957j
	CHEMBL235329	95328	1	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	236	6	1	3	1.7	COc1cccc(N(C)CCCNC(C)=O)c1	10.1021/jm700957j
	1357	9263	139	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1672	9263	139	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	224	9263	139	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	896	9263	139	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	CHEMBL45	9263	139	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	DB01065	9263	139	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	139451757	191610	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4852096	191610	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	1357	9263	139	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1672	9263	139	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	224	9263	139	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	896	9263	139	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	CHEMBL45	9263	139	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	DB01065	9263	139	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	53238182	68794	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	5	1	3	3.8	CC(=O)NCCC1=C(Cc2ccsc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774520	68794	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	5	1	3	3.8	CC(=O)NCCC1=C(Cc2ccsc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	44358274	35726	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	261	2	2	3	1.1	CNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL138012	35726	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	261	2	2	3	1.1	CNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	9937825	15640	0	None	12	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	564	17	2	4	6.7	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097315	15640	0	None	12	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	564	17	2	4	6.7	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12	10.1016/j.bmc.2010.04.008
	49865268	22649	0	None	13	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(OC(C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223128	22649	0	None	13	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(OC(C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	44272335	75451	0	None	-23	2	Human	9.0	pKi	=	9.0	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	7	2	3	3.6	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCC)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL19211	75451	0	None	-23	2	Human	9.0	pKi	=	9.0	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	7	2	3	3.6	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCC)N2	10.1016/j.bmcl.2003.12.052
	9817636	27447	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	295	4	1	2	3.4	COc1ccc2cccc3c2c1CCC3CNC(=O)C1CC1	10.1021/jm000922c
	CHEMBL130876	27447	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	295	4	1	2	3.4	COc1ccc2cccc3c2c1CCC3CNC(=O)C1CC1	10.1021/jm000922c
	44272410	74791	0	None	-7	2	Human	9.0	pKi	=	9.0	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	274	5	2	3	2.9	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL19128	74791	0	None	-7	2	Human	9.0	pKi	=	9.0	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	274	5	2	3	2.9	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1	10.1016/j.bmcl.2003.12.052
	44389812	69776	0	None	19	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	365	10	1	2	4.9	CCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL178678	69776	0	None	19	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	365	10	1	2	4.9	CCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	11581340	129119	0	None	1	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	363	8	1	2	4.6	CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL359921	129119	0	None	1	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	363	8	1	2	4.6	CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	20590653	130053	0	None	5	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	389	9	1	2	5.0	O=C(NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1	10.1016/j.bmcl.2005.01.015
	CHEMBL361410	130053	0	None	5	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	389	9	1	2	5.0	O=C(NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1	10.1016/j.bmcl.2005.01.015
	20590654	136948	0	None	1	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	377	9	1	2	5.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL367797	136948	0	None	1	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	377	9	1	2	5.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	44264892	211959	0	None	-5	2	Human	9.0	pKi	=	9	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	284	5	1	3	3.8	CCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7832	211959	0	None	-5	2	Human	9.0	pKi	=	9	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	284	5	1	3	3.8	CCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	139451799	192618	0	None	3	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	279	5	1	5	1.9	COc1ccc2nc(SC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4867553	192618	0	None	3	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	279	5	1	5	1.9	COc1ccc2nc(SC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	145979689	173402	0	None	-5	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	314	3	2	2	3.1	CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4280791	173402	0	None	-5	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	314	3	2	2	3.1	CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145993214	173530	0	None	-5	3	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	285	3	2	3	2.2	CNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4283539	173530	0	None	-5	3	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	285	3	2	3	2.2	CNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	11110447	214568	0	None	-4	2	Human	9.0	pKi	=	9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	6	1	3	4.3	C/C=C/C(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL96104	214568	0	None	-4	2	Human	9.0	pKi	=	9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	6	1	3	4.3	C/C=C/C(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	9850873	15639	0	None	13	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	564	15	2	4	6.4	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12)C1CC1	10.1016/j.bmc.2010.04.008
	CHEMBL1097314	15639	0	None	13	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	564	15	2	4	6.4	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12)C1CC1	10.1016/j.bmc.2010.04.008
	10753255	125269	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	251	3	1	1	3.0	O=C(NCC1Cc2cccc3cccc1c23)C1CC1	10.1021/jm000922c
	CHEMBL341439	125269	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	251	3	1	1	3.0	O=C(NCC1Cc2cccc3cccc1c23)C1CC1	10.1021/jm000922c
	18007985	15488	0	None	10	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	538	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095832	15488	0	None	10	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	538	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	44264769	103772	0	None	-10	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	298	6	1	3	4.2	CCCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL266549	103772	0	None	-10	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	298	6	1	3	4.2	CCCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	139451761	191376	0	None	4	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4848885	191376	0	None	4	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451769	192921	0	None	1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC	10.1021/acs.jmedchem.0c00627
	CHEMBL4872217	192921	0	None	1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC	10.1021/acs.jmedchem.0c00627
	53237950	68792	0	None	-13	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	314	5	2	2	3.3	CCNC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774517	68792	0	None	-13	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	314	5	2	2	3.3	CCNC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	53238186	68798	0	None	-54	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1ccccc1C1=C(CCNC(C)=O)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
	CHEMBL1774525	68798	0	None	-54	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1ccccc1C1=C(CCNC(C)=O)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
	10873443	202003	4	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	417	5	1	5	2.4	COc1cc2c(CCNC(C)=O)c(I)n(C)c2cc1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL55084	202003	4	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	417	5	1	5	2.4	COc1cc2c(CCNC(C)=O)c(I)n(C)c2cc1[N+](=O)[O-]	10.1021/jm011053+
	11536239	83477	1	None	2	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	2	2	2.6	COc1ccc2[nH]cc(C(C)(C)CNC(C)=O)c2c1	10.1021/jm0512544
	CHEMBL206472	83477	1	None	2	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	2	2	2.6	COc1ccc2[nH]cc(C(C)(C)CNC(C)=O)c2c1	10.1021/jm0512544
	24763223	7004	0	None	74	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 mins	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1039/C5MD00190K
	8289	7004	0	None	74	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 mins	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1039/C5MD00190K
	CHEMBL3260987	7004	0	None	74	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 mins	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1039/C5MD00190K
	20642483	37425	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	272	3	1	3	1.7	O=C(N[C@H]1CCN(c2cccc3c2CCO3)C1)C1CC1	10.1016/j.bmcl.2003.09.030
	CHEMBL139439	37425	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	272	3	1	3	1.7	O=C(N[C@H]1CCN(c2cccc3c2CCO3)C1)C1CC1	10.1016/j.bmcl.2003.09.030
	10752506	26758	0	None	-5	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	2	1	1	3.0	CC(=O)NCC1CCc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL130319	26758	0	None	-5	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	2	1	1	3.0	CC(=O)NCC1CCc2cccc3cccc1c23	10.1021/jm000922c
	85880795	117645	0	None	12	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	319	9	1	3	4.0	CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2	10.1021/jm401343c
	CHEMBL3260984	117645	0	None	12	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	319	9	1	3	4.0	CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2	10.1021/jm401343c
	139451767	191783	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854625	191783	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	127041169	143626	0	None	6	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	570	14	2	4	5.7	O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	CHEMBL3741890	143626	0	None	6	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	570	14	2	4	5.7	O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	57781248	191342	0	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	4	2	4	1.9	CC(=O)NCCC1CCc2ccc3nc(CO)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4848381	191342	0	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	4	2	4	1.9	CC(=O)NCCC1CCc2ccc3nc(CO)oc3c21	10.1021/acs.jmedchem.0c01836
	11644612	85073	0	None	-9	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
	CHEMBL210791	85073	0	None	-9	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
	127041169	143626	0	None	6	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	570	14	2	4	5.7	O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	CHEMBL3741890	143626	0	None	6	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	570	14	2	4	5.7	O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	164946945	197008	1	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5174929	197008	1	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	9927219	119099	0	None	-25	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL329263	119099	0	None	-25	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	9927219	119099	0	None	-25	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 mins	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.5b00982
	CHEMBL329263	119099	0	None	-25	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 mins	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.5b00982
	9927219	119099	0	None	-25	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm401343c
	CHEMBL329263	119099	0	None	-25	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm401343c
	10019103	74267	0	None	-5	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	323	5	1	2	3.8	CCCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm040768k
	CHEMBL189395	74267	0	None	-5	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	323	5	1	2	3.8	CCCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm040768k
	10089253	123863	0	None	12	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	350	9	1	3	4.5	CC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL339265	123863	0	None	12	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	350	9	1	3	4.5	CC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	10022570	175326	0	None	13	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	378	10	1	3	5.1	CC(C)C(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL435586	175326	0	None	13	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	378	10	1	3	5.1	CC(C)C(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	44353165	123692	0	None	-7	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	267	4	1	1	3.8	CCCC(=O)NCC1CCc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL338425	123692	0	None	-7	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	267	4	1	1	3.8	CCCC(=O)NCC1CCc2cccc3cccc1c23	10.1021/jm000922c
	44272438	77084	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	5	2	3	3.3	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL19441	77084	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	5	2	3	3.3	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	52918079	67529	0	None	-4	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	261	6	1	4	2.0	CCCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	CHEMBL1760947	67529	0	None	-4	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	261	6	1	4	2.0	CCCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	57781208	192400	0	None	-5	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	320	4	1	3	4.1	CC(=O)NCCC1CCc2ccc3nc(-c4ccccc4)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4864102	192400	0	None	-5	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	320	4	1	3	4.1	CC(=O)NCCC1CCc2ccc3nc(-c4ccccc4)oc3c21	10.1021/acs.jmedchem.0c01836
	53238412	68804	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	375	4	1	3	4.8	CC(=O)NCCC1=C(c2csc3ccccc23)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774531	68804	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	375	4	1	3	4.8	CC(=O)NCCC1=C(c2csc3ccccc23)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	10763177	31509	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	393	7	1	4	3.2	CCC(=O)NCCc1c(OC(=O)CBr)ccc2ccc(OC)cc12	10.1021/jm970437q
	CHEMBL134416	31509	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	393	7	1	4	3.2	CCC(=O)NCCc1c(OC(=O)CBr)ccc2ccc(OC)cc12	10.1021/jm970437q
	10850411	122135	0	None	-4	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	281	4	1	2	3.0	COc1ccc2cccc3c2c1C(CNC(=O)C1CC1)C3	10.1021/jm000922c
	CHEMBL334962	122135	0	None	-4	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	281	4	1	2	3.0	COc1ccc2cccc3c2c1C(CNC(=O)C1CC1)C3	10.1021/jm000922c
	20355585	117642	6	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	280	4	2	2	2.8	COc1cc2c(CCNC(C)=O)c(C)[nH]c2cc1Cl	10.1021/jm401343c
	CHEMBL3260979	117642	6	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	280	4	2	2	2.8	COc1cc2c(CCNC(C)=O)c(C)[nH]c2cc1Cl	10.1021/jm401343c
	10244841	74269	1	None	-8	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	309	4	1	2	3.5	CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm040768k
	CHEMBL189414	74269	1	None	-8	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	309	4	1	2	3.5	CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm040768k
	23642306	165852	1	None	2	3	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4097233	165852	1	None	2	3	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	9870683	15661	0	None	9	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	502	13	2	5	5.2	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4occ(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097496	15661	0	None	9	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	502	13	2	5	5.2	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4occ(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	52918077	67527	2	None	-2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760945	67527	2	None	-2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	10244841	74269	1	None	-8	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	309	4	1	2	3.5	CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm800974d
	CHEMBL189414	74269	1	None	-8	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	309	4	1	2	3.5	CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm800974d
	53238411	68803	0	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	375	4	1	2	4.9	CC(=O)NCCC1=C(c2ccc(C(C)(C)C)cc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774530	68803	0	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	375	4	1	2	4.9	CC(=O)NCCC1=C(c2ccc(C(C)(C)C)cc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	12004056	181001	0	None	13	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	340	6	3	3	2.0	CC(=O)NCCc1c(Br)[nH]c2ccc(OCCO)cc12	10.1016/j.ejmech.2019.111847
	CHEMBL4548591	181001	0	None	13	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	340	6	3	3	2.0	CC(=O)NCCc1c(Br)[nH]c2ccc(OCCO)cc12	10.1016/j.ejmech.2019.111847
	44358184	123318	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	246	2	1	3	1.3	CC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL336268	123318	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	246	2	1	3	1.3	CC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	46845151	15438	0	None	38	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	499	12	2	4	6.1	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095505	15438	0	None	38	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	499	12	2	4	6.1	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12	10.1016/j.bmc.2010.04.008
	137641357	163858	0	None	-3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4074273	163858	0	None	-3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	122188351	129944	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.7	CCC(=O)NCC1CCc2ccccc2N1c1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612608	129944	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.7	CCC(=O)NCC1CCc2ccccc2N1c1ccccc1	10.1021/acs.jmedchem.5b01066
	19703015	144676	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	234	4	1	4	1.5	COc1ccc2occ(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3763281	144676	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	234	4	1	4	1.5	COc1ccc2occ(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	11630146	84860	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	246	4	2	2	2.4	COc1ccc2[nH]cc(C(C)CNC(C)=O)c2c1	10.1021/jm0512544
	CHEMBL210147	84860	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	246	4	2	2	2.4	COc1ccc2[nH]cc(C(C)CNC(C)=O)c2c1	10.1021/jm0512544
	49865204	22622	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(O[C@@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223050	22622	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(O[C@@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	44429442	157002	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	5	2	2	2.6	CCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL395221	157002	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	5	2	2	2.6	CCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	44272443	202266	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	6	2	3	3.5	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL553105	202266	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	6	2	3	3.5	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	9858255	214856	0	None	-30	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	320	4	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1	10.1021/jm980684+
	CHEMBL9772	214856	0	None	-30	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	320	4	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1	10.1021/jm980684+
	168296374	199297	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	CHEMBL5209359	199297	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	10542922	123370	0	None	6	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	309	5	1	2	3.8	COc1ccc2cccc3c2c1CCC3CCNC(=O)C1CC1	10.1021/jm000922c
	CHEMBL336633	123370	0	None	6	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	309	5	1	2	3.8	COc1ccc2cccc3c2c1CCC3CCNC(=O)C1CC1	10.1021/jm000922c
	127026427	144462	0	None	-3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758679	144462	0	None	-3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	122220128	166454	0	None	-5	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	6	2	3	2.3	COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1	10.1039/C4MD00149D
	CHEMBL4104020	166454	0	None	-5	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	6	2	3	2.3	COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1	10.1039/C4MD00149D
	10637638	27373	0	None	4	2	Human	8.0	pKi	=	8	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	295	5	1	2	3.4	COc1ccc2cccc3c2c1C(CCNC(=O)C1CC1)C3	10.1021/jm000922c
	CHEMBL130813	27373	0	None	4	2	Human	8.0	pKi	=	8	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	295	5	1	2	3.4	COc1ccc2cccc3c2c1C(CCNC(=O)C1CC1)C3	10.1021/jm000922c
	127026424	144470	0	None	-5	2	Human	8.0	pKi	=	8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3oc(CCNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758720	144470	0	None	-5	2	Human	8.0	pKi	=	8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3oc(CCNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	44394415	131185	0	None	1	2	Human	8.0	pKi	=	8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	389	10	1	2	6.0	CCCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL363947	131185	0	None	1	2	Human	8.0	pKi	=	8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	389	10	1	2	6.0	CCCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	44429449	94138	0	None	-7	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	324	4	1	3	2.6	COc1cc(Br)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
	CHEMBL233309	94138	0	None	-7	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	324	4	1	3	2.6	COc1cc(Br)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
	11536939	83889	0	None	-12	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	314	6	1	3	3.5	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	CHEMBL207625	83889	0	None	-12	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	314	6	1	3	3.5	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	44264818	212004	0	None	-91	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	283	6	1	2	4.0	CCCC(=O)Nc1ccc(Cc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7867	212004	0	None	-91	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	283	6	1	2	4.0	CCCC(=O)Nc1ccc(Cc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	44359437	36673	0	None	1	3	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1039/C4MD00149D
	CHEMBL138807	36673	0	None	1	3	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1039/C4MD00149D
	10526493	212073	0	None	-1	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	427	8	1	3	3.7	CCC(=O)NCCc1c(OCCI)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL79224	212073	0	None	-1	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	427	8	1	3	3.7	CCC(=O)NCCc1c(OCCI)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	24750188	156023	0	None	-114	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	314	7	1	4	3.0	COc1ccc(N(CCNC(C)=O)c2cccc(OC)c2)cc1	10.1021/jm700957j
	CHEMBL394430	156023	0	None	-114	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	314	7	1	4	3.0	COc1ccc(N(CCNC(C)=O)c2cccc(OC)c2)cc1	10.1021/jm700957j
	16105169	181456	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	345	3	1	3	3.3	CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2	10.1016/j.bmc.2009.04.068
	CHEMBL455909	181456	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	345	3	1	3	3.3	CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2	10.1016/j.bmc.2009.04.068
	45268309	203050	0	None	-4	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	303	7	2	3	2.3	CCN(C)Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2009.04.068
	CHEMBL561928	203050	0	None	-4	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	303	7	2	3	2.3	CCN(C)Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2009.04.068
	16105169	181456	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	345	3	1	3	3.3	CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2	10.1016/j.bmc.2008.07.012
	CHEMBL455909	181456	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	345	3	1	3	3.3	CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2	10.1016/j.bmc.2008.07.012
	25210130	6857	0	None	-91	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
	7782	6857	0	None	-91	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
	CHEMBL514415	6857	0	None	-91	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
	1358	6912	41	None	-870	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm048956y
	3976006	6912	41	None	-870	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm048956y
	CHEMBL285718	6912	41	None	-870	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm048956y
	54584155	67530	0	None	-2	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	366	8	1	5	2.8	COc1ccc2c(CN(C)Cc3ccccc3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760949	67530	0	None	-2	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	366	8	1	5	2.8	COc1ccc2c(CN(C)Cc3ccccc3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	49865148	22603	2	None	-2	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1ccccc1OC(C)CNC(C)=O	10.1016/j.bmc.2010.06.100
	CHEMBL1222984	22603	2	None	-2	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1ccccc1OC(C)CNC(C)=O	10.1016/j.bmc.2010.06.100
	44394478	73063	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	404	8	1	3	5.3	CC(C)C(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	CHEMBL184762	73063	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	404	8	1	3	5.3	CC(C)C(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	44264849	212151	0	None	-19	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	298	5	1	3	4.1	COc1cccc(N(C)c2ccc(NC(=O)C(C)C)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL7990	212151	0	None	-19	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	298	5	1	3	4.1	COc1cccc(N(C)c2ccc(NC(=O)C(C)C)cc2)c1	10.1016/j.bmcl.2003.11.030
	10956792	108588	7	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1ccc2[nH]cc(CCNC(C)=O)c2c1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL300195	108588	7	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1ccc2[nH]cc(CCNC(C)=O)c2c1[N+](=O)[O-]	10.1021/jm011053+
	25210135	181703	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	378	6	3	4	3.0	COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL456505	181703	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	378	6	3	4	3.0	COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	25210135	181703	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	378	6	3	4	3.0	COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL456505	181703	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	378	6	3	4	3.0	COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	45268310	203342	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	419	7	2	3	4.5	COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	CHEMBL563847	203342	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	419	7	2	3	4.5	COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	46935149	22623	2	None	2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC(C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223051	22623	2	None	2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC(C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	44394508	72919	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	404	9	1	3	5.5	CCCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	CHEMBL184144	72919	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	404	9	1	3	5.5	CCCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	10831675	28552	0	None	-6	2	Human	8.0	pKi	=	8.0	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	349	7	1	4	3.1	CCC(=O)NCCc1c(OC(=O)CCl)ccc2ccc(OC)cc12	10.1021/jm970437q
	CHEMBL131919	28552	0	None	-6	2	Human	8.0	pKi	=	8.0	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	349	7	1	4	3.1	CCC(=O)NCCc1c(OC(=O)CCl)ccc2ccc(OC)cc12	10.1021/jm970437q
	1346	6948	47	None	-25	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1016/j.ejmech.2019.111847
	1858	6948	47	None	-25	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1016/j.ejmech.2019.111847
	CHEMBL34730	6948	47	None	-25	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1016/j.ejmech.2019.111847
	1346	6948	47	None	-25	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1021/jm401343c
	1858	6948	47	None	-25	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1021/jm401343c
	CHEMBL34730	6948	47	None	-25	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1021/jm401343c
	11587169	84092	0	None	-8	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	4	1	3	2.6	COc1ccc2c(c1)c(C(C)(C)CNC(C)=O)cn2C	10.1021/jm0512544
	CHEMBL208307	84092	0	None	-8	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	4	1	3	2.6	COc1ccc2c(c1)c(C(C)(C)CNC(C)=O)cn2C	10.1021/jm0512544
	127041170	143467	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	584	15	2	4	6.1	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	CHEMBL3740377	143467	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	584	15	2	4	6.1	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	45268303	203524	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	301	4	1	4	1.8	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCN(C)C1	10.1016/j.bmc.2009.04.068
	CHEMBL565176	203524	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	301	4	1	4	1.8	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCN(C)C1	10.1016/j.bmc.2009.04.068
	44272424	75850	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	289	4	3	3	2.5	CNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL19237	75850	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	289	4	3	3	2.5	CNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	11666721	71764	0	None	-18	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	1	4	2.7	CNC(=O)CCc1c(-c2ccccc2)nc2ccc(OC)cn12	10.1016/j.ejmech.2011.06.030
	CHEMBL1823016	71764	0	None	-18	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	1	4	2.7	CNC(=O)CCc1c(-c2ccccc2)nc2ccc(OC)cn12	10.1016/j.ejmech.2011.06.030
	45268310	203342	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	419	7	2	3	4.5	COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	CHEMBL563847	203342	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	419	7	2	3	4.5	COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	1362	10210	22	None	39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	9870523	10210	22	None	39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	CHEMBL429392	10210	22	None	39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	11403195	130457	1	None	1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	278	3	1	2	3.4	CC(=O)NCCN1c2ccccc2C=Cc2ccccc21	10.1021/jm040768k
	CHEMBL362133	130457	1	None	1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	278	3	1	2	3.4	CC(=O)NCCN1c2ccccc2C=Cc2ccccc21	10.1021/jm040768k
	90666309	116163	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CCC3)c2c1	10.1039/C1MD00149C
	CHEMBL3219330	116163	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CCC3)c2c1	10.1039/C1MD00149C
	1362	10210	22	None	39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	9870523	10210	22	None	39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	CHEMBL429392	10210	22	None	39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	25210130	6857	0	None	-91	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
	7782	6857	0	None	-91	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
	CHEMBL514415	6857	0	None	-91	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
	16743124	98984	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	282	5	1	2	3.0	O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CC1	10.1016/j.ejmech.2007.01.005
	CHEMBL242573	98984	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	282	5	1	2	3.0	O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CC1	10.1016/j.ejmech.2007.01.005
	162661094	188222	3	None	-10	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4764211	188222	3	None	-10	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	12436516	22628	6	None	-2	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	179	4	1	2	1.2	CC(=O)NCCOc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223056	22628	6	None	-2	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	179	4	1	2	1.2	CC(=O)NCCOc1ccccc1	10.1016/j.bmc.2010.06.100
	49865377	22706	0	None	1	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC[C@@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223280	22706	0	None	1	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC[C@@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	10664333	214962	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	332	4	1	2	4.3	CCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
	CHEMBL9838	214962	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	332	4	1	2	4.3	CCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
	122188227	129923	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	233	3	3	2	1.7	CCNC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612458	129923	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	233	3	3	2	1.7	CCNC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	22718579	23294	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	5	1	3	3.0	CC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL123690	23294	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	5	1	3	3.0	CC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	11543959	83899	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	6	2	2	3.5	CCCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	CHEMBL207676	83899	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	6	2	2	3.5	CCCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	11791741	214889	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	344	4	1	2	4.3	O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CC1	10.1021/jm980684+
	CHEMBL9791	214889	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	344	4	1	2	4.3	O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CC1	10.1021/jm980684+
	46885228	14477	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	341	10	1	3	4.1	CCCC(=O)NCCCc1cc(OC)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
	CHEMBL1088825	14477	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	341	10	1	3	4.1	CCCC(=O)NCCCc1cc(OC)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
	22718619	23546	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	7	1	3	3.8	CCCC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124445	23546	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	7	1	3	3.8	CCCC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	44264844	211641	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	296	5	1	3	3.8	COc1cccc(N(C)c2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL7567	211641	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	296	5	1	3	3.8	COc1cccc(N(C)c2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
	127041170	143467	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	584	15	2	4	6.1	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	CHEMBL3740377	143467	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	584	15	2	4	6.1	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	145964105	170997	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	475	12	2	5	4.9	CC(=O)NCCN(C)c1cccc(OCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4211018	170997	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	475	12	2	5	4.9	CC(=O)NCCN(C)c1cccc(OCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	11068422	214623	0	None	-7	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	361	6	1	4	4.7	COc1ccc2oc(-c3ccccc3)c(CCNC(=O)c3ccco3)c2c1	10.1021/jm0005252
	CHEMBL96420	214623	0	None	-7	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	361	6	1	4	4.7	COc1ccc2oc(-c3ccccc3)c(CCNC(=O)c3ccco3)c2c1	10.1021/jm0005252
	127038225	144766	0	None	-13	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	338	5	1	4	3.8	COc1ccc2oc(-c3c(C)cccc3C)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3764421	144766	0	None	-13	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	338	5	1	4	3.8	COc1ccc2oc(-c3c(C)cccc3C)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	25210134	196403	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	315	6	2	3	2.5	COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL514904	196403	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	315	6	2	3	2.5	COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	49865317	22666	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(S[C@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223191	22666	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(S[C@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	10544425	215116	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	330	4	1	2	4.1	O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CCC1	10.1021/jm980684+
	CHEMBL9934	215116	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	330	4	1	2	4.1	O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CCC1	10.1021/jm980684+
	16094578	90047	1	None	-8	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.4	CC(=O)NC/C(=C\c1ccccc1)c1ccccc1	10.1021/jm060850a
	CHEMBL218808	90047	1	None	-8	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.4	CC(=O)NC/C(=C\c1ccccc1)c1ccccc1	10.1021/jm060850a
	12436514	22699	6	None	-3	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)NC(C)COc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223273	22699	6	None	-3	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)NC(C)COc1ccccc1	10.1016/j.bmc.2010.06.100
	49865376	22705	2	None	-9	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SCC(C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223279	22705	2	None	-9	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SCC(C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	25210134	196403	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	315	6	2	3	2.5	COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL514904	196403	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	315	6	2	3	2.5	COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	46865422	93846	0	None	-575	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326199	93846	0	None	-575	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	54586061	67533	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	441	7	1	6	3.2	COc1ccc2c(CN3CCN(c4cccc(Cl)c4)CC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760952	67533	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	441	7	1	6	3.2	COc1ccc2c(CN3CCN(c4cccc(Cl)c4)CC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	122188238	129933	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.1	CC(=O)NC[C@@H]1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612470	129933	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.1	CC(=O)NC[C@@H]1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	10656443	215154	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	218	3	2	2	1.8	COc1cccc2[nH]c(CNC(C)=O)cc12	10.1021/jm001125h
	CHEMBL99534	215154	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	218	3	2	2	1.8	COc1cccc2[nH]c(CNC(C)=O)cc12	10.1021/jm001125h
	10656443	215154	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	218	3	2	2	1.8	COc1cccc2[nH]c(CNC(C)=O)cc12	10.1021/jm970721h
	CHEMBL99534	215154	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	218	3	2	2	1.8	COc1cccc2[nH]c(CNC(C)=O)cc12	10.1021/jm970721h
	137660180	165901	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	270	5	1	3	2.3	COc1cnc2cccc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2016.12.013
	CHEMBL4097817	165901	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	270	5	1	3	2.3	COc1cnc2cccc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2016.12.013
	44579164	188909	0	None	-14	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	406	7	2	4	4.8	CCOC(=O)Nc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	CHEMBL478218	188909	0	None	-14	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	406	7	2	4	4.8	CCOC(=O)Nc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	12985494	197408	0	None	-239	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	363	7	2	3	4.1	CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
	CHEMBL518113	197408	0	None	-239	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	363	7	2	3	4.1	CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
	24750190	96660	1	None	-32	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	254	5	1	2	3.0	CC(=O)NCCN(c1ccccc1)c1ccccc1	10.1021/jm700957j
	CHEMBL237840	96660	1	None	-32	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	254	5	1	2	3.0	CC(=O)NCCN(c1ccccc1)c1ccccc1	10.1021/jm700957j
	44429455	94523	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	322	5	1	3	3.5	COc1cc(-c2ccccc2)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
	CHEMBL233740	94523	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	322	5	1	3	3.5	COc1cc(-c2ccccc2)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
	12985492	188610	0	None	-177	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	459	6	1	2	5.1	COc1ccc2cc(-c3cccc(CI)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL477833	188610	0	None	-177	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	459	6	1	2	5.1	COc1ccc2cc(-c3cccc(CI)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	46885283	15027	0	None	-48	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	237	6	1	3	1.8	COc1ccc(OC)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1092400	15027	0	None	-48	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	237	6	1	3	1.8	COc1ccc(OC)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	10428383	10685	5	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm001125h
	7783	10685	5	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm001125h
	CHEMBL33185	10685	5	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm001125h
	10903368	214883	0	None	-4	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2ccc(OC)cc2n1Cc1ccccc1	10.1021/jm001125h
	CHEMBL97885	214883	0	None	-4	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2ccc(OC)cc2n1Cc1ccccc1	10.1021/jm001125h
	45267465	201546	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	365	8	2	3	3.5	COc1ccc2[nH]c(CN(C)Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	CHEMBL538129	201546	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	365	8	2	3	3.5	COc1ccc2[nH]c(CN(C)Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	24750195	95329	0	None	-24	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	298	6	0	3	3.3	COc1cccc(N(CCN(C)C(C)=O)c2ccccc2)c1	10.1021/jm700957j
	CHEMBL235334	95329	0	None	-24	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	298	6	0	3	3.3	COc1cccc(N(CCN(C)C(C)=O)c2ccccc2)c1	10.1021/jm700957j
	10428383	10685	5	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm048956y
	7783	10685	5	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm048956y
	CHEMBL33185	10685	5	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm048956y
	44429452	94140	0	None	-4	2	Human	4.9	pKi	=	4.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	308	5	2	2	3.5	COc1cc(-c2ccccc2)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
	CHEMBL233311	94140	0	None	-4	2	Human	4.9	pKi	=	4.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	308	5	2	2	3.5	COc1cc(-c2ccccc2)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
	44358087	123191	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	3	1	3	2.0	CC(C)C(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL336024	123191	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	3	1	3	2.0	CC(C)C(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	10428383	10685	5	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Antagonist activity at human MT1 receptorAntagonist activity at human MT1 receptor	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm401343c
	7783	10685	5	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Antagonist activity at human MT1 receptorAntagonist activity at human MT1 receptor	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm401343c
	CHEMBL33185	10685	5	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Antagonist activity at human MT1 receptorAntagonist activity at human MT1 receptor	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm401343c
	10428383	10685	5	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm800974d
	7783	10685	5	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm800974d
	CHEMBL33185	10685	5	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm800974d
	139451766	191226	0	None	-8	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4846505	191226	0	None	-8	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	122188225	129921	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	218	3	2	2	1.9	CCC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612456	129921	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	218	3	2	2	1.9	CCC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	122193492	130720	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	261	4	1	4	1.5	COc1ccc2oc(=O)cc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2015.09.003
	CHEMBL3628489	130720	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	261	4	1	4	1.5	COc1ccc2oc(=O)cc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2015.09.003
	53238410	68802	0	None	-1174	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	361	5	1	2	4.7	CC(=O)NCCC1=C(c2cccc(C(C)C)c2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774529	68802	0	None	-1174	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	361	5	1	2	4.7	CC(=O)NCCC1=C(c2cccc(C(C)C)c2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	22718610	23660	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	308	6	1	3	4.0	CCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL125033	23660	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	308	6	1	3	4.0	CCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	22718602	103319	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	6	1	3	3.1	CCc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL262890	103319	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	6	1	3	3.1	CCc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
	24750189	96255	0	None	-1174	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	334	6	1	3	4.1	COc1cccc(N(CCNC(C)=O)c2ccc3ccccc3c2)c1	10.1021/jm700957j
	CHEMBL237234	96255	0	None	-1174	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	334	6	1	3	4.1	COc1cccc(N(CCNC(C)=O)c2ccc3ccccc3c2)c1	10.1021/jm700957j
	122188232	129927	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	353	6	2	3	3.3	CCNC(=O)NCC1CCc2c(OC)cccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612463	129927	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	353	6	2	3	3.3	CCNC(=O)NCC1CCc2c(OC)cccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	44581851	181990	0	None	-1202	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	333	6	1	2	4.5	COc1cccc(C(CCNC(C)=O)c2ccc3ccccc3c2)c1	10.1021/jm800974d
	CHEMBL457128	181990	0	None	-1202	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	333	6	1	2	4.5	COc1cccc(C(CCNC(C)=O)c2ccc3ccccc3c2)c1	10.1021/jm800974d
	10610443	215086	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	246	5	2	2	2.2	CCC(=O)NCCc1cc2c(OC)cccc2[nH]1	10.1021/jm001125h
	CHEMBL99084	215086	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	246	5	2	2	2.2	CCC(=O)NCCc1cc2c(OC)cccc2[nH]1	10.1021/jm001125h
	10610443	215086	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	246	5	2	2	2.2	CCC(=O)NCCc1cc2c(OC)cccc2[nH]1	10.1021/jm970721h
	CHEMBL99084	215086	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	246	5	2	2	2.2	CCC(=O)NCCc1cc2c(OC)cccc2[nH]1	10.1021/jm970721h
	46865422	93846	0	None	-575	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1039/C1MD00149C
	CHEMBL2326199	93846	0	None	-575	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1039/C1MD00149C
	46865422	93846	0	None	-575	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.ejmech.2016.01.008
	CHEMBL2326199	93846	0	None	-575	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.ejmech.2016.01.008
	44579259	193893	0	None	-331	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	347	6	1	3	4.0	COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL491604	193893	0	None	-331	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	347	6	1	3	4.0	COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	12436515	22604	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)NCC(C)Oc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1222985	22604	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)NCC(C)Oc1ccccc1	10.1016/j.bmc.2010.06.100
	10427851	188612	0	None	-407	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	348	6	2	3	3.7	COc1ccc2cc(-c3cccc(CN)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL477834	188612	0	None	-407	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	348	6	2	3	3.7	COc1ccc2cc(-c3cccc(CN)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	86273227	128095	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	242	4	2	2	1.5	C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580907	128095	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	242	4	2	2	1.5	C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	44429450	94139	0	None	-6	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	338	5	1	3	3.0	CCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL233310	94139	0	None	-6	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	338	5	1	3	3.0	CCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	11824364	119329	0	None	-42	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1ccc2oc(Cc3ccccc3OC)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL329960	119329	0	None	-42	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1ccc2oc(Cc3ccccc3OC)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	56671857	71227	0	None	10	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	384	13	1	4	4.3	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2ccccc2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813324	71227	0	None	10	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	384	13	1	4	4.3	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2ccccc2)c1	10.1016/j.bmc.2011.06.063
	10617720	214598	0	None	-56	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2Cc2ccccc2-1	10.1021/jm980684+
	CHEMBL9630	214598	0	None	-56	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2Cc2ccccc2-1	10.1021/jm980684+
	3956219	108324	11	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1cc2c(CCNC(C)=O)c[nH]c2cc1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL298335	108324	11	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1cc2c(CCNC(C)=O)c[nH]c2cc1[N+](=O)[O-]	10.1021/jm011053+
	127027022	144587	0	None	-19	3	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	314	4	2	3	3.6	CCNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759677	144587	0	None	-19	3	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	314	4	2	3	3.6	CCNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	25210132	177656	0	None	-9	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3CCc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1021/jm800974d
	CHEMBL445427	177656	0	None	-9	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3CCc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1021/jm800974d
	10829695	125983	0	None	-21	2	Human	6.9	pKi	=	6.9	Binding	Binding Affinity (pKi) towards Melatonin receptor type 1ABinding Affinity (pKi) towards Melatonin receptor type 1A	ChEMBL	322	6	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1	10.1021/jm020982d
	CHEMBL34327	125983	0	None	-21	2	Human	6.9	pKi	=	6.9	Binding	Binding Affinity (pKi) towards Melatonin receptor type 1ABinding Affinity (pKi) towards Melatonin receptor type 1A	ChEMBL	322	6	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1	10.1021/jm020982d
	10829695	125983	0	None	-21	2	Human	6.9	pKi	=	6.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	322	6	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1	10.1021/jm048956y
	CHEMBL34327	125983	0	None	-21	2	Human	6.9	pKi	=	6.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	322	6	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1	10.1021/jm048956y
	25210132	177656	0	None	-9	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3CCc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1021/jm800974d
	CHEMBL445427	177656	0	None	-9	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3CCc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1021/jm800974d
	22718585	23278	0	None	-9	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	6	1	3	3.4	CCC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL123634	23278	0	None	-9	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	6	1	3	3.4	CCC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	46884599	15191	0	None	-13	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1cccc(COc2ccc(CCCNC(C)=O)cc2OC)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1093457	15191	0	None	-13	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1cccc(COc2ccc(CCCNC(C)=O)cc2OC)c1	10.1016/j.bmcl.2010.02.084
	25209860	195762	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.8	COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL508552	195762	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.8	COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	168274836	196926	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5173623	196926	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	162647716	186666	0	None	-3	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4745789	186666	0	None	-3	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	10853020	104942	0	None	-15	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	4	1	2	3.9	CCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
	CHEMBL273897	104942	0	None	-15	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	4	1	2	3.9	CCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
	25209860	195762	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.8	COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL508552	195762	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.8	COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	11536746	146229	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	4	1	3	3.1	COc1ccc2c(c1)c(C1(CNC(C)=O)CCCC1)cn2C	10.1021/jm0512544
	CHEMBL379403	146229	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	4	1	3	3.1	COc1ccc2c(c1)c(C1(CNC(C)=O)CCCC1)cn2C	10.1021/jm0512544
	44241666	202875	0	None	-6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	351	7	2	3	3.5	COc1ccc2[nH]c(CN(C)c3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	CHEMBL560865	202875	0	None	-6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	351	7	2	3	3.5	COc1ccc2[nH]c(CN(C)c3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	44429445	94307	0	None	-6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	5	1	3	2.6	CCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL233516	94307	0	None	-6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	5	1	3	2.6	CCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	12985496	189110	0	None	-31	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	389	7	2	3	4.5	COc1ccc2cc(-c3cccc(CO)c3)cc(CCNC(=O)C3CCC3)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL478438	189110	0	None	-31	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	389	7	2	3	4.5	COc1ccc2cc(-c3cccc(CO)c3)cc(CCNC(=O)C3CCC3)c2c1	10.1016/j.bmc.2008.08.052
	44412079	173036	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	4	2	3	2.8	CCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
	CHEMBL426861	173036	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	4	2	3	2.8	CCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
	11098363	175895	1	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	293	5	1	2	3.7	CC(=O)NCCc1c(Cc2ccccc2)oc2ccccc12	10.1021/jm0005252
	CHEMBL440144	175895	1	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	293	5	1	2	3.7	CC(=O)NCCc1c(Cc2ccccc2)oc2ccccc12	10.1021/jm0005252
	127025786	144627	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12	10.1016/j.ejmech.2015.12.047
	CHEMBL3760044	144627	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12	10.1016/j.ejmech.2015.12.047
	127025782	144509	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	297	4	1	3	3.9	COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759054	144509	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	297	4	1	3	3.9	COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1	10.1016/j.ejmech.2015.12.047
	122162	9166	75	None	-18	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm401343c
	1363	9166	75	None	-18	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm401343c
	CHEMBL286615	9166	75	None	-18	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm401343c
	54581170	67537	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	359	4	1	4	1.8	COc1ccc2c(I)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760956	67537	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	359	4	1	4	1.8	COc1ccc2c(I)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	137660726	166111	0	None	-15	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	322	6	1	5	1.6	CCS(=O)(=O)NC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4100108	166111	0	None	-15	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	322	6	1	5	1.6	CCS(=O)(=O)NC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	18522267	73099	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	377	11	1	2	5.8	CCCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL184990	73099	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	377	11	1	2	5.8	CCCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	44394394	129488	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	387	9	1	2	5.6	O=C(NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12)C1CC1	10.1016/j.bmcl.2004.07.055
	CHEMBL360428	129488	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	387	9	1	2	5.6	O=C(NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12)C1CC1	10.1016/j.bmcl.2004.07.055
	145971624	171392	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	517	15	2	5	6.0	CCC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4215980	171392	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	517	15	2	5	6.0	CCC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	10849065	6925	8	None	4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1345	6925	8	None	4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	CHEMBL126809	6925	8	None	4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	24750191	95327	0	None	-85	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	332	5	1	2	3.7	CC(=O)NCCN(c1ccccc1)c1cccc(Br)c1	10.1021/jm700957j
	CHEMBL235328	95327	0	None	-85	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	332	5	1	2	3.7	CC(=O)NCCN(c1ccccc1)c1cccc(Br)c1	10.1021/jm700957j
	11392720	73825	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	309	4	1	2	3.5	COc1ccc2c(c1)C(CCNC(C)=O)Cc1ccccc1C2	10.1021/jm040768k
	CHEMBL187160	73825	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	309	4	1	2	3.5	COc1ccc2c(c1)C(CCNC(C)=O)Cc1ccccc1C2	10.1021/jm040768k
	10513752	115277	3	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2[nH]c(CCNC(C)=O)cc2c1	10.1021/jm001125h
	CHEMBL319970	115277	3	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2[nH]c(CCNC(C)=O)cc2c1	10.1021/jm001125h
	10513752	115277	3	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2[nH]c(CCNC(C)=O)cc2c1	10.1021/jm970721h
	CHEMBL319970	115277	3	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2[nH]c(CCNC(C)=O)cc2c1	10.1021/jm970721h
	22718571	23610	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	8	1	3	3.6	CCCC(=O)NCCCc1cccc2nc(CCC)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124782	23610	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	8	1	3	3.6	CCCC(=O)NCCCc1cccc2nc(CCC)oc12	10.1016/j.bmcl.2004.04.082
	121231413	10681	1	None	-16982	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	10.1021/acs.jmedchem.5b01066
	9226	10681	1	None	-16982	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	10.1021/acs.jmedchem.5b01066
	CHEMBL3612464	10681	1	None	-16982	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	10.1021/acs.jmedchem.5b01066
	86273229	128097	1	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	244	5	2	2	2.0	C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580909	128097	1	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	244	5	2	2	2.0	C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	127025787	144510	0	None	-4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	298	4	2	3	3.4	CCNC(=O)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759080	144510	0	None	-4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	298	4	2	3	3.4	CCNC(=O)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	44587357	194929	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	393	7	3	4	2.8	COc1ccc2[nH]c(CN3c4ccccc4CC3CO)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.07.012
	CHEMBL498494	194929	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	393	7	3	4	2.8	COc1ccc2[nH]c(CN3c4ccccc4CC3CO)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.07.012
	44358218	34289	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	289	4	2	3	1.9	CCCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL136895	34289	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	289	4	2	3	1.9	CCCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	86273222	128101	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580913	128101	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1	10.1021/acs.jmedchem.5b00245
	11515177	147838	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	314	5	1	3	3.4	COc1ccc2c(c1)c(C(C)(C)CNC(=O)C1CCC1)cn2C	10.1021/jm0512544
	CHEMBL382439	147838	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	314	5	1	3	3.4	COc1ccc2c(c1)c(C(C)(C)CNC(=O)C1CCC1)cn2C	10.1021/jm0512544
	122188348	129942	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	308	5	1	2	3.2	CC(=O)NCC1CCc2ccccc2N1CCc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612605	129942	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	308	5	1	2	3.2	CC(=O)NCC1CCc2ccccc2N1CCc1ccccc1	10.1021/acs.jmedchem.5b01066
	10591657	11448	0	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	5	1	2	4.1	CCCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
	CHEMBL10328	11448	0	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	5	1	2	4.1	CCCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
	11616029	84769	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	272	4	1	3	2.4	COc1ccc2c(c1)c(C1(CNC(C)=O)CC1)cn2C	10.1021/jm0512544
	CHEMBL209711	84769	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	272	4	1	3	2.4	COc1ccc2c(c1)c(C1(CNC(C)=O)CC1)cn2C	10.1021/jm0512544
	16105170	196506	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm800974d
	CHEMBL515696	196506	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm800974d
	44264871	211809	0	None	-26	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	297	5	1	3	4.2	CCCC(=O)Nc1ccc(Oc2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7700	211809	0	None	-26	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	297	5	1	3	4.2	CCCC(=O)Nc1ccc(Oc2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
	10854190	105089	0	None	-87	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	5	1	3	3.7	CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1	10.1021/jm980684+
	CHEMBL274896	105089	0	None	-87	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	5	1	3	3.7	CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1	10.1021/jm980684+
	15453819	211762	0	None	-30	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	287	6	1	4	3.1	COCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7659	211762	0	None	-30	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	287	6	1	4	3.1	COCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	16105170	196506	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to MT1 receptor (unknown origin)Binding affinity to MT1 receptor (unknown origin)	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm401343c
	CHEMBL515696	196506	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to MT1 receptor (unknown origin)Binding affinity to MT1 receptor (unknown origin)	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm401343c
	16105170	196506	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm800974d
	CHEMBL515696	196506	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm800974d
	16105170	196506	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1016/j.bmc.2008.07.012
	CHEMBL515696	196506	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1016/j.bmc.2008.07.012
	10447987	123747	2	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	308	5	1	3	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2-c1ccccc1	10.1021/jm020982d
	CHEMBL33869	123747	2	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	308	5	1	3	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2-c1ccccc1	10.1021/jm020982d
	90666303	116157	0	None	-31	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	361	6	2	3	3.9	COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
	CHEMBL3219324	116157	0	None	-31	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	361	6	2	3	3.9	COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
	23658145	164242	1	None	-33	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4079214	164242	1	None	-33	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	10705590	214986	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	246	4	1	3	1.9	COc1ccc2cc(CCNC(C)=O)n(C)c2c1	10.1021/jm001125h
	CHEMBL98484	214986	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	246	4	1	3	1.9	COc1ccc2cc(CCNC(C)=O)n(C)c2c1	10.1021/jm001125h
	10705590	214986	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	246	4	1	3	1.9	COc1ccc2cc(CCNC(C)=O)n(C)c2c1	10.1021/jm970721h
	CHEMBL98484	214986	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	246	4	1	3	1.9	COc1ccc2cc(CCNC(C)=O)n(C)c2c1	10.1021/jm970721h
	16105170	196506	0	None	-4	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1016/j.bmc.2009.04.068
	CHEMBL515696	196506	0	None	-4	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1016/j.bmc.2009.04.068
	22718521	23425	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	2.8	CCCc1nc2cccc(CCCNC(C)=O)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL124216	23425	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	2.8	CCCc1nc2cccc(CCCNC(C)=O)c2o1	10.1016/j.bmcl.2004.04.082
	46885284	14877	0	None	-114	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	251	7	1	3	2.2	CCOc1ccc(OC)cc1CCCNC(C)=O	10.1016/j.bmcl.2010.02.084
	CHEMBL1091561	14877	0	None	-114	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	251	7	1	3	2.2	CCOc1ccc(OC)cc1CCCNC(C)=O	10.1016/j.bmcl.2010.02.084
	46884552	14899	0	None	-1122	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	314	8	1	4	2.7	COc1ccc(OCc2ccccn2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1091716	14899	0	None	-1122	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	314	8	1	4	2.7	COc1ccc(OCc2ccccn2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	122188233	129928	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2cc(OC)ccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612465	129928	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2cc(OC)ccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	145977894	170628	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	372	11	2	5	3.2	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(O)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4206516	170628	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	372	11	2	5	3.2	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(O)c2)c1	10.1021/acs.jmedchem.8b00893
	10454621	108657	4	None	-47	2	Human	5.7	pKi	=	5.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	417	5	1	5	2.4	COc1ccc2c(c(CCNC(C)=O)c(I)n2C)c1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL300728	108657	4	None	-47	2	Human	5.7	pKi	=	5.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	417	5	1	5	2.4	COc1ccc2c(c(CCNC(C)=O)c(I)n2C)c1[N+](=O)[O-]	10.1021/jm011053+
	137636173	162780	0	None	-63	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	276	6	1	3	2.3	COc1ccc2cccc(CCC(=O)NCCF)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4061905	162780	0	None	-63	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	276	6	1	3	2.3	COc1ccc2cccc(CCC(=O)NCCF)c2n1	10.1016/j.ejmech.2016.12.013
	71540275	93184	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	225	2	1	1	2.8	CC(=O)N[C@@H]1C[C@H]1c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
	CHEMBL2314250	93184	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	225	2	1	1	2.8	CC(=O)N[C@@H]1C[C@H]1c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
	18522208	134064	0	None	6	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	349	9	1	2	5.1	CC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL365852	134064	0	None	6	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	349	9	1	2	5.1	CC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	24750077	155823	0	None	-691	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	314	7	1	4	3.0	COc1cccc(N(CCNC(C)=O)c2cccc(OC)c2)c1	10.1021/jm700957j
	CHEMBL394273	155823	0	None	-691	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	314	7	1	4	3.0	COc1cccc(N(CCNC(C)=O)c2cccc(OC)c2)c1	10.1021/jm700957j
	10069719	200177	4	None	1	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	403	5	2	4	2.4	COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL52559	200177	4	None	1	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	403	5	2	4	2.4	COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1[N+](=O)[O-]	10.1021/jm011053+
	44429446	153510	0	None	-14	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	288	6	1	3	3.0	CCCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL392422	153510	0	None	-14	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	288	6	1	3	3.0	CCCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	56671856	71225	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	526	19	2	6	4.6	CC(=O)NCCN(C)c1cccc(OCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813322	71225	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	526	19	2	6	4.6	CC(=O)NCCN(C)c1cccc(OCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	16743294	98856	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	256	4	1	2	2.7	CC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
	CHEMBL241928	98856	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	256	4	1	2	2.7	CC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
	1550607	109845	68	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	298	6	0	3	4.9	CC(C)=CCC/C(C)=C/COc1ccc2ccc(=O)oc2c1	10.1021/acs.jnatprod.7b00853
	CHEMBL307341	109845	68	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	298	6	0	3	4.9	CC(C)=CCC/C(C)=C/COc1ccc2ccc(=O)oc2c1	10.1021/acs.jnatprod.7b00853
	44349269	23360	1	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	289	6	2	3	3.2	CCNC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL123972	23360	1	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	289	6	2	3	3.2	CCNC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	10517621	214843	0	None	-11	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	290	3	1	2	3.3	CC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
	CHEMBL9765	214843	0	None	-11	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	290	3	1	2	3.3	CC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
	127039212	144805	0	None	-154	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	5	1	4	4.3	COc1ccc2oc(-c3cccc4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3764879	144805	0	None	-154	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	5	1	4	4.3	COc1ccc2oc(-c3cccc4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	10245336	45994	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	318	5	2	1	4.3	O=C(NCCc1c(-c2ccccc2)[nH]c2ccccc12)C1CCC1	10.1021/jm970721h
	CHEMBL14701	45994	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	318	5	2	1	4.3	O=C(NCCc1c(-c2ccccc2)[nH]c2ccccc12)C1CCC1	10.1021/jm970721h
	44389845	71606	0	None	15	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	377	10	1	2	4.9	O=C(NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1	10.1016/j.bmcl.2005.01.015
	CHEMBL181974	71606	0	None	15	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	377	10	1	2	4.9	O=C(NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1	10.1016/j.bmcl.2005.01.015
	20590652	136756	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	391	10	1	2	5.4	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL367604	136756	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	391	10	1	2	5.4	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	44389813	138152	0	None	15	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	379	11	1	2	5.3	CCCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL368886	138152	0	None	15	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	379	11	1	2	5.3	CCCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	145991966	173615	0	None	-5	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	285	3	1	3	3.2	COC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4285145	173615	0	None	-5	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	285	3	1	3	3.2	COC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145987794	173899	0	None	-19	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	298	4	2	2	3.2	CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4290302	173899	0	None	-19	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	298	4	2	2	3.2	CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145988269	173969	0	None	-10	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	326	5	2	2	3.8	CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4291381	173969	0	None	-10	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	326	5	2	2	3.8	CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137639112	163631	0	None	-10	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	245	4	2	3	1.5	COc1ccc2cccc(CCNC(N)=O)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4071572	163631	0	None	-10	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	245	4	2	3	1.5	COc1ccc2cccc(CCNC(N)=O)c2n1	10.1016/j.ejmech.2016.12.013
	137655238	165664	0	None	-19	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	275	4	2	3	1.9	CNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4095210	165664	0	None	-19	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	275	4	2	3	1.9	CNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	9805364	43737	0	None	89	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	484	11	2	4	4.8	CC(=O)NCCc1cccc2ccc(OCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	CHEMBL14514	43737	0	None	89	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	484	11	2	4	4.8	CC(=O)NCCc1cccc2ccc(OCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	9796251	124888	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCC(=O)NCCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	CHEMBL340745	124888	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCC(=O)NCCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	139451790	192075	18	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859295	192075	18	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	127026062	144467	0	None	-5	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758717	144467	0	None	-5	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	44394438	73738	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	375	9	1	2	5.6	CCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL186736	73738	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	375	9	1	2	5.6	CCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	44358238	126150	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	261	2	2	3	1.1	CNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL344449	126150	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	261	2	2	3	1.1	CNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	10333442	210665	0	None	-5	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	272	6	1	3	2.7	CCCC(=O)NCCc1ccnc2ccc(OC)cc12	10.1016/S0960-894X(97)00392-2
	CHEMBL68864	210665	0	None	-5	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	272	6	1	3	2.7	CCCC(=O)NCCc1ccnc2ccc(OC)cc12	10.1016/S0960-894X(97)00392-2
	139451776	191790	0	None	5	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854836	191790	0	None	5	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	10754723	175977	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	273	5	2	3	2.6	CCC(=O)NCCc1c(O)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL440692	175977	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	273	5	2	3	2.6	CCC(=O)NCCc1c(O)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	127040021	144797	0	None	-24	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	5	1	4	4.3	COc1ccc2oc(-c3ccc4ccccc4c3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3764765	144797	0	None	-24	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	5	1	4	4.3	COc1ccc2oc(-c3ccc4ccccc4c3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	11776674	123427	1	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	246	4	1	3	1.9	COc1ccc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm020982d
	CHEMBL33700	123427	1	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	246	4	1	3	1.9	COc1ccc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm020982d
	10038243	123739	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	3.0	CCCC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL338659	123739	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	3.0	CCCC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	168274836	196926	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5173623	196926	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	10301190	15337	0	None	7	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	511	12	1	5	6.2	COC(=O)c1ccc(-c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc2)cc1	10.1016/j.bmc.2010.04.008
	CHEMBL1094545	15337	0	None	7	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	511	12	1	5	6.2	COC(=O)c1ccc(-c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc2)cc1	10.1016/j.bmc.2010.04.008
	137641357	163858	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4074273	163858	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	44394535	73787	0	None	2	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	390	8	1	3	5.1	CCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	CHEMBL186977	73787	0	None	2	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	390	8	1	3	5.1	CCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	86273228	128098	0	None	-5	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	258	6	2	2	2.4	C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580910	128098	0	None	-5	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	258	6	2	2	2.4	C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	11776674	123427	1	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	246	4	1	3	1.9	COc1ccc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm011053+
	CHEMBL33700	123427	1	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	246	4	1	3	1.9	COc1ccc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm011053+
	44394435	73701	0	None	3	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	361	8	1	2	5.2	CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL186586	73701	0	None	3	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	361	8	1	2	5.2	CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	10561982	29794	0	None	-12	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	3	1	1	3.0	CCC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL133001	29794	0	None	-12	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	3	1	1	3.0	CCC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	16094584	90020	0	None	-33	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
	CHEMBL218708	90020	0	None	-33	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
	44429441	93501	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	246	4	2	2	2.2	COc1cc(C)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
	CHEMBL231872	93501	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	246	4	2	2	2.2	COc1cc(C)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
	53237951	68793	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	333	5	1	2	3.7	CC(=O)NCCC1=C(Cc2ccccc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774518	68793	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	333	5	1	2	3.7	CC(=O)NCCC1=C(Cc2ccccc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	10332159	23566	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	5	1	3	2.6	CCC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124577	23566	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	5	1	3	2.6	CCC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	127026423	144597	0	None	-31	3	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759802	144597	0	None	-31	3	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	44429443	152123	0	None	-4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	6	2	2	2.9	CCCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL391350	152123	0	None	-4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	6	2	2	2.9	CCCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	9839199	28135	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	CHEMBL131424	28135	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	137636079	163006	0	None	-19	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	232	3	1	2	1.8	CCN1CC(CNC(C)=O)Cc2ccccc21	10.1021/acs.jmedchem.8b00359
	CHEMBL4064626	163006	0	None	-19	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	232	3	1	2	1.8	CCN1CC(CNC(C)=O)Cc2ccccc21	10.1021/acs.jmedchem.8b00359
	127026425	144598	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759816	144598	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	53310838	70565	0	None	-4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	321	4	1	4	2.8	CC(=O)NCCn1c(-c2ccccc2)nc2ccc3c(c21)CCO3	10.1021/jm200385u
	CHEMBL1802021	70565	0	None	-4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	321	4	1	4	2.8	CC(=O)NCCn1c(-c2ccccc2)nc2ccc3c(c21)CCO3	10.1021/jm200385u
	44424018	92133	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	620	16	4	8	4.2	COc1ccc2[nH]c(C(=O)OCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL226162	92133	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	620	16	4	8	4.2	COc1ccc2[nH]c(C(=O)OCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	56661499	71198	0	None	102	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	456	14	2	6	2.7	CC(=O)NCCN(C)c1cccc(OCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813174	71198	0	None	102	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	456	14	2	6	2.7	CC(=O)NCCN(C)c1cccc(OCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	46884555	15114	0	None	-16	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.7	CCC(=O)NCCCc1ccc(OCc2ccccc2)c(OC)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1092911	15114	0	None	-16	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.7	CCC(=O)NCCCc1ccc(OCc2ccccc2)c(OC)c1	10.1016/j.bmcl.2010.02.084
	44358088	33554	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	246	2	1	3	1.3	CC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL136273	33554	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	246	2	1	3	1.3	CC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	10518621	104090	0	None	-11	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	304	4	1	2	3.7	CCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
	CHEMBL269175	104090	0	None	-11	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	304	4	1	2	3.7	CCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
	12985493	193871	0	None	-213	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	363	7	1	3	4.3	COCc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	CHEMBL491403	193871	0	None	-213	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	363	7	1	3	4.3	COCc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	10736247	215142	0	None	-5	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	344	4	1	2	4.3	O=C(NCCc1c2n(c3ccccc13)CCc1ccccc1-2)C1CCC1	10.1021/jm980684+
	CHEMBL9950	215142	0	None	-5	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	344	4	1	2	4.3	O=C(NCCc1c2n(c3ccccc13)CCc1ccccc1-2)C1CCC1	10.1021/jm980684+
	11208578	132667	0	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	292	2	1	2	3.0	CC(=O)NCC(=O)N1c2ccccc2C=Cc2ccccc21	10.1021/jm040768k
	CHEMBL364845	132667	0	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	292	2	1	2	3.0	CC(=O)NCC(=O)N1c2ccccc2C=Cc2ccccc21	10.1021/jm040768k
	189748	23588	9	None	-60	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	262	5	2	3	1.9	COc1cc2[nH]cc(CCNC(C)=O)c2cc1OC	10.1021/jm401343c
	CHEMBL124699	23588	9	None	-60	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	262	5	2	3	1.9	COc1cc2[nH]cc(CCNC(C)=O)c2cc1OC	10.1021/jm401343c
	11287002	22701	2	None	-4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)N[C@@H](C)COc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223275	22701	2	None	-4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)N[C@@H](C)COc1ccccc1	10.1016/j.bmc.2010.06.100
	44358217	34285	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	287	3	2	3	1.7	O=C(NC1CC1)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL136894	34285	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	287	3	2	3	1.7	O=C(NC1CC1)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	44394456	72890	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	378	10	2	2	5.3	CCNC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL183962	72890	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	378	10	2	2	5.3	CCNC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	145963877	171035	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	503	14	2	5	5.7	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4211530	171035	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	503	14	2	5	5.7	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	10385056	119013	0	None	-194	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL329086	119013	0	None	-194	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	10385056	119013	0	None	-194	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm401343c
	CHEMBL329086	119013	0	None	-194	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm401343c
	145	6928	49	None	-40	30	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1832	6928	49	None	-40	30	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	CHEMBL7257	6928	49	None	-40	30	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	DB14010	6928	49	None	-40	30	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	122178507	128102	0	None	-13	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580915	128102	0	None	-13	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	127025170	144520	0	None	-4	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759180	144520	0	None	-4	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	162656758	187701	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4757920	187701	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	162658247	187797	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2cnnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4759137	187797	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2cnnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	11688043	84770	0	None	-28	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	6	1	3	3.1	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1	10.1021/jm0512544
	CHEMBL209712	84770	0	None	-28	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	6	1	3	3.1	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1	10.1021/jm0512544
	122188234	129929	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2ccc(OC)cc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612466	129929	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2ccc(OC)cc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	44424019	92134	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	648	18	4	8	5.0	COc1ccc2[nH]c(C(=O)OCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL226163	92134	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	648	18	4	8	5.0	COc1ccc2[nH]c(C(=O)OCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	16094595	90036	4	None	-407	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.4	COc1cccc(C(CCNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
	CHEMBL218773	90036	4	None	-407	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.4	COc1cccc(C(CCNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
	44412078	146295	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	272	3	2	3	2.4	CC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
	CHEMBL379504	146295	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	272	3	2	3	2.4	CC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
	137637884	163025	0	None	-10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.3	CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4064813	163025	0	None	-10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.3	CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	122188352	129945	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	263	3	2	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612609	129945	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	263	3	2	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	44394532	74020	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	376	7	1	3	4.7	CC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	CHEMBL188016	74020	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	376	7	1	3	4.7	CC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	11351216	69178	0	None	-4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	441	6	1	3	5.4	O=C(CBr)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779807	69178	0	None	-4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	441	6	1	3	5.4	O=C(CBr)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	162668689	189537	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	285	5	1	4	2.2	COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4790145	189537	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	285	5	1	4	2.2	COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	71508233	93849	0	None	-40	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	355	10	1	3	3.9	CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326201	93849	0	None	-40	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	355	10	1	3	3.9	CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	11066802	106863	0	None	-21	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	308	5	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
	CHEMBL287343	106863	0	None	-21	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	308	5	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
	11463056	69176	0	None	-51	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	1	3	5.4	CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779805	69176	0	None	-51	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	1	3	5.4	CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	11131123	177412	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	323	6	1	3	3.7	COc1cccc(Cc2oc3ccccc3c2CCNC(C)=O)c1	10.1021/jm0005252
	CHEMBL445117	177412	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	323	6	1	3	3.7	COc1cccc(Cc2oc3ccccc3c2CCNC(C)=O)c1	10.1021/jm0005252
	16094593	172823	0	None	-91	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C\CNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
	CHEMBL425644	172823	0	None	-91	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C\CNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
	44349305	177915	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	320	6	1	3	4.0	O=C(NCCCc1cccc2nc(-c3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2004.04.082
	CHEMBL445840	177915	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	320	6	1	3	4.0	O=C(NCCCc1cccc2nc(-c3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2004.04.082
	23725513	132626	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648357	132626	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	44394416	73012	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	389	9	1	2	5.9	CC(C)C(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL184562	73012	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	389	9	1	2	5.9	CC(C)C(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	10750842	195461	3	None	-30	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	207	5	1	2	1.8	COc1cccc(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL50398	195461	3	None	-30	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	207	5	1	2	1.8	COc1cccc(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	127026426	144578	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759606	144578	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	90666307	116161	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	389	8	2	3	3.9	C=CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12	10.1039/C1MD00149C
	CHEMBL3219328	116161	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	389	8	2	3	3.9	C=CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12	10.1039/C1MD00149C
	16094584	90020	0	None	-33	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1	10.1021/jm800974d
	CHEMBL218708	90020	0	None	-33	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1	10.1021/jm800974d
	86079062	187511	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2ncnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4755860	187511	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2ncnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	10808489	214554	0	None	-42	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	360	6	1	3	4.1	CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1	10.1021/jm980684+
	CHEMBL9600	214554	0	None	-42	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	360	6	1	3	4.1	CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1	10.1021/jm980684+
	53231464	69180	0	None	-21	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	375	6	1	3	5.2	C=CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779809	69180	0	None	-21	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	375	6	1	3	5.2	C=CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	11173131	130876	0	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	265	2	1	1	3.1	CC(=O)NCC1Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
	CHEMBL363321	130876	0	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	265	2	1	1	3.1	CC(=O)NCC1Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
	11014883	214907	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	400	6	1	3	4.1	COc1ccc2c(Br)c(CCNC(C)=O)n(Cc3ccccc3)c2c1	10.1021/jm001125h
	CHEMBL98028	214907	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	400	6	1	3	4.1	COc1ccc2c(Br)c(CCNC(C)=O)n(Cc3ccccc3)c2c1	10.1021/jm001125h
	22718576	121383	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	1	3	2.2	CC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL333810	121383	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	1	3	2.2	CC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	11824365	114144	0	None	-47	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1ccc(Cc2oc3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1021/jm0005252
	CHEMBL317742	114144	0	None	-47	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1ccc(Cc2oc3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1021/jm0005252
	44424021	148869	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	690	21	4	8	6.2	COc1ccc2[nH]c(C(=O)OCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL388141	148869	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	690	21	4	8	6.2	COc1ccc2[nH]c(C(=O)OCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	53231465	69174	0	None	-5	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	237	3	1	2	2.7	CC(=O)NCCc1csc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779803	69174	0	None	-5	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	237	3	1	2	2.7	CC(=O)NCCc1csc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	44579260	193894	0	None	-38	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	377	6	1	4	4.0	COC(=O)c1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	CHEMBL491605	193894	0	None	-38	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	377	6	1	4	4.0	COC(=O)c1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	10853021	104913	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	3	1	2	3.9	CC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
	CHEMBL273623	104913	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	3	1	2	3.9	CC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
	10465460	215085	2	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	202	3	2	1	1.8	CC(=O)NCCc1cc2ccccc2[nH]1	10.1021/jm001125h
	CHEMBL99083	215085	2	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	202	3	2	1	1.8	CC(=O)NCCc1cc2ccccc2[nH]1	10.1021/jm001125h
	10465460	215085	2	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	202	3	2	1	1.8	CC(=O)NCCc1cc2ccccc2[nH]1	10.1021/jm970721h
	CHEMBL99083	215085	2	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	202	3	2	1	1.8	CC(=O)NCCc1cc2ccccc2[nH]1	10.1021/jm970721h
	137656715	166326	0	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	308	5	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(CCc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4102517	166326	0	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	308	5	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(CCc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	71540393	93188	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	226	2	2	1	2.7	CNC(=O)N/C=C/c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
	CHEMBL2314254	93188	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	226	2	2	1	2.7	CNC(=O)N/C=C/c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
	127038130	143401	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	347	8	1	2	4.5	CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3739824	143401	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	347	8	1	2	4.5	CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12	10.1039/C5MD00190K
	44424022	90247	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	718	23	4	8	6.9	COc1ccc2[nH]c(C(=O)OCCCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL220091	90247	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	718	23	4	8	6.9	COc1ccc2[nH]c(C(=O)OCCCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	10737123	104155	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	358	4	1	2	4.7	O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CCC1	10.1021/jm980684+
	CHEMBL269670	104155	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	358	4	1	2	4.7	O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CCC1	10.1021/jm980684+
	90666302	116156	0	None	-11	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.4	COc1ccc2[nH]c(CN3CCc4ccccc4C3)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
	CHEMBL3219323	116156	0	None	-11	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.4	COc1ccc2[nH]c(CN3CCc4ccccc4C3)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
	CHEMBL3109562	217869	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 mins	ChEMBL		None	None	None		CCC1=C(C)C2=Cc3c(CCNC(C)=O)c4cc(OC)ccc4n3[B-](F)(F)[N+]2=C1C	10.1021/ml4004155
	10596576	10945	0	None	-39	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	390	7	1	3	5.1	CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)CCCc1ccccc1-2	10.1021/jm980684+
	CHEMBL10007	10945	0	None	-39	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	390	7	1	3	5.1	CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)CCCc1ccccc1-2	10.1021/jm980684+
	46884598	14962	0	None	-20	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	223	5	2	3	1.5	COc1cc(CCCNC(C)=O)ccc1O	10.1016/j.bmcl.2010.02.084
	CHEMBL1092047	14962	0	None	-20	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	223	5	2	3	1.5	COc1cc(CCCNC(C)=O)ccc1O	10.1016/j.bmcl.2010.02.084
	45269177	201644	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	299	5	1	3	2.5	CCCC(=O)NCCc1c2n(c3ccccc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
	CHEMBL540182	201644	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	299	5	1	3	2.5	CCCC(=O)NCCc1c2n(c3ccccc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
	45269183	202804	0	None	-6	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	385	7	2	3	4.1	COc1ccc2[nH]c(CN(C)c3ccc(Cl)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	CHEMBL560186	202804	0	None	-6	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	385	7	2	3	4.1	COc1ccc2[nH]c(CN(C)c3ccc(Cl)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	16094594	90021	0	None	-165	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	321	6	1	2	4.0	COc1cccc(/C(=C\CNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm060850a
	CHEMBL218709	90021	0	None	-165	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	321	6	1	2	4.0	COc1cccc(/C(=C\CNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm060850a
	162674581	190091	0	None	-51	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	268	3	1	4	2.7	COc1ccc2cccc(/C=C/c3n[nH]c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	CHEMBL4797226	190091	0	None	-51	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	268	3	1	4	2.7	COc1ccc2cccc(/C=C/c3n[nH]c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	46885227	14845	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
	CHEMBL1091161	14845	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
	16743464	99101	0	None	-11	2	Human	5.6	pKi	=	5.6	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	310	3	1	2	3.9	CC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1	10.1016/j.ejmech.2007.01.005
	CHEMBL243002	99101	0	None	-11	2	Human	5.6	pKi	=	5.6	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	310	3	1	2	3.9	CC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1	10.1016/j.ejmech.2007.01.005
	10714573	105269	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	CHEMBL276005	105269	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	1353	10208	5	None	-112	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm800974d
	9998187	10208	5	None	-112	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm800974d
	CHEMBL33549	10208	5	None	-112	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm800974d
	145976375	170576	0	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	525	15	2	6	5.7	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4206000	170576	0	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	525	15	2	6	5.7	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1	10.1021/acs.jmedchem.8b00893
	46885288	15101	0	None	-95	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1ccc(COc2ccc(OC)cc2CCCNC(C)=O)cc1	10.1016/j.bmcl.2010.02.084
	CHEMBL1092839	15101	0	None	-95	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1ccc(COc2ccc(OC)cc2CCCNC(C)=O)cc1	10.1016/j.bmcl.2010.02.084
	10760155	105195	0	None	-43	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	4	1	3	3.9	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	CHEMBL275529	105195	0	None	-43	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	4	1	3	3.9	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	7922	8737	0	None	-741	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	10.1016/j.bmc.2008.08.052
	9798456	8737	0	None	-741	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	10.1016/j.bmc.2008.08.052
	CHEMBL476131	8737	0	None	-741	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	10.1016/j.bmc.2008.08.052
	11045144	215061	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	310	4	2	2	3.0	CCC(=O)NCc1[nH]c2cc(OC)ccc2c1Br	10.1021/jm001125h
	CHEMBL98956	215061	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	310	4	2	2	3.0	CCC(=O)NCc1[nH]c2cc(OC)ccc2c1Br	10.1021/jm001125h
	49865205	22624	0	None	-4	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(S[C@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223052	22624	0	None	-4	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(S[C@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	137644121	164928	0	None	-7	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	291	4	1	1	4.0	CCC(=O)NCC1=C(c2ccccc2)c2ccccc2CC1	10.1021/acs.jmedchem.8b00359
	CHEMBL4087265	164928	0	None	-7	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	291	4	1	1	4.0	CCC(=O)NCC1=C(c2ccccc2)c2ccccc2CC1	10.1021/acs.jmedchem.8b00359
	11702296	71765	6	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	1	4	2.7	COc1ccc2nc(-c3ccccc3)c(CCNC(C)=O)n2c1	10.1016/j.ejmech.2011.06.030
	CHEMBL1823017	71765	6	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	1	4	2.7	COc1ccc2nc(-c3ccccc3)c(CCNC(C)=O)n2c1	10.1016/j.ejmech.2011.06.030
	86273223	128099	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	242	3	1	3	3.1	COc1ccc2[nH]cc(Cc3ncc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580911	128099	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	242	3	1	3	3.1	COc1ccc2[nH]cc(Cc3ncc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	90666305	116159	0	None	-125	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
	CHEMBL3219326	116159	0	None	-125	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
	49865266	22647	2	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1ccc(SCCNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223126	22647	2	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1ccc(SCCNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
	10520058	104914	0	None	-8	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	324	3	1	2	4.0	CC(=O)NCCc1c2n(c3ccc(Cl)cc13)Cc1ccccc1-2	10.1021/jm980684+
	CHEMBL273624	104914	0	None	-8	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	324	3	1	2	4.0	CC(=O)NCCc1c2n(c3ccc(Cl)cc13)Cc1ccccc1-2	10.1021/jm980684+
	53231367	69179	0	None	-117	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	425	8	1	3	6.0	O=C(CCCCl)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779808	69179	0	None	-117	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	425	8	1	3	6.0	O=C(CCCCl)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	11078652	214697	0	None	-16	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	7	1	3	4.3	CCc1ccc2oc(Cc3cccc(OC)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL96778	214697	0	None	-16	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	7	1	3	4.3	CCc1ccc2oc(Cc3cccc(OC)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	10641756	105054	0	None	-57	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	352	3	1	2	4.6	CC(=O)NCCc1c2n(c3ccc(Cl)cc13)CCCc1ccccc1-2	10.1021/jm980684+
	CHEMBL274630	105054	0	None	-57	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	352	3	1	2	4.6	CC(=O)NCCc1c2n(c3ccc(Cl)cc13)CCCc1ccccc1-2	10.1021/jm980684+
	56662799	71230	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	526	15	2	6	2.9	COc1cccc(N(CCNC(C)=O)C(=O)CCCCC(=O)N(CCNC(C)=O)c2cccc(OC)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813327	71230	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	526	15	2	6	2.9	COc1cccc(N(CCNC(C)=O)C(=O)CCCCC(=O)N(CCNC(C)=O)c2cccc(OC)c2)c1	10.1016/j.bmc.2011.06.063
	11088627	214324	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	324	6	1	4	3.1	COc1ccc2oc(Cc3cccnc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL94745	214324	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	324	6	1	4	3.1	COc1ccc2oc(Cc3cccnc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	15453821	211884	0	None	-151	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	301	6	1	3	4.6	CCCC(=O)Nc1ccc(Sc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7771	211884	0	None	-151	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	301	6	1	3	4.6	CCCC(=O)Nc1ccc(Sc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	145983175	173210	0	None	-14	3	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	314	4	2	2	3.4	CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4277390	173210	0	None	-14	3	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	314	4	2	2	3.4	CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137661786	165894	0	None	-4	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	262	5	1	3	1.9	COc1cnc2cccc(CCNC(=O)CF)c2c1	10.1016/j.ejmech.2016.12.013
	CHEMBL4097693	165894	0	None	-4	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	262	5	1	3	1.9	COc1cnc2cccc(CCNC(=O)CF)c2c1	10.1016/j.ejmech.2016.12.013
	145975938	170678	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	519	14	3	6	5.4	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(O)c3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4207166	170678	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	519	14	3	6	5.4	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(O)c3)c2)c1	10.1021/acs.jmedchem.8b00893
	122188239	129934	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	320	5	1	2	3.5	O=C(NCC1CCc2ccccc2N1Cc1ccccc1)C1CC1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612471	129934	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	320	5	1	2	3.5	O=C(NCC1CCc2ccccc2N1Cc1ccccc1)C1CC1	10.1021/acs.jmedchem.5b01066
	46885286	14940	0	None	-218	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.4	COc1ccc(OCCc2ccccc2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1091895	14940	0	None	-218	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.4	COc1ccc(OCCc2ccccc2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	10620323	215119	0	None	-34	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	388	6	1	3	4.7	CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	CHEMBL9935	215119	0	None	-34	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	388	6	1	3	4.7	CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	10658090	215073	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	246	5	2	2	2.2	COc1ccc2[nH]c(CCCNC(C)=O)cc2c1	10.1021/jm001125h
	CHEMBL99000	215073	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	246	5	2	2	2.2	COc1ccc2[nH]c(CCCNC(C)=O)cc2c1	10.1021/jm001125h
	10658090	215073	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	246	5	2	2	2.2	COc1ccc2[nH]c(CCCNC(C)=O)cc2c1	10.1021/jm970721h
	CHEMBL99000	215073	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	246	5	2	2	2.2	COc1ccc2[nH]c(CCCNC(C)=O)cc2c1	10.1021/jm970721h
	12985490	187999	0	None	-12	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2cc(-c3ccc(CO)cc3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL476132	187999	0	None	-12	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2cc(-c3ccc(CO)cc3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	10015474	25332	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	5	1	3	2.8	Cc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL127596	25332	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	5	1	3	2.8	Cc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
	145979282	173454	0	None	-16	3	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4281915	173454	0	None	-16	3	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	53238408	68800	0	None	-81	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1ccc(C2=C(CCNC(C)=O)c3c(ccc4c3CCO4)C2)cc1	10.1021/jm200221q
	CHEMBL1774527	68800	0	None	-81	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1ccc(C2=C(CCNC(C)=O)c3c(ccc4c3CCO4)C2)cc1	10.1021/jm200221q
	11426853	173147	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	309	3	1	3	2.7	COc1ccc2c(c1)C(CNC(C)=O)Cc1ccccc1C2=O	10.1021/jm040768k
	CHEMBL427516	173147	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	309	3	1	3	2.7	COc1ccc2c(c1)C(CNC(C)=O)Cc1ccccc1C2=O	10.1021/jm040768k
	137641357	163858	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4074273	163858	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	49865321	22670	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NC[C@H](C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223195	22670	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NC[C@H](C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	44272406	75957	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	289	5	3	3	2.7	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CC)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL19260	75957	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	289	5	3	3	2.7	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CC)N2	10.1016/j.bmcl.2003.12.052
	1355	10211	5	None	70	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	9806449	10211	5	None	70	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	CHEMBL14453	10211	5	None	70	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	71540395	93191	0	None	2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	256	3	2	2	2.7	CNC(=O)N/C=C/c1c(OC)ccc2ccccc12	10.1016/j.bmcl.2012.11.069
	CHEMBL2314258	93191	0	None	2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	256	3	2	2	2.7	CNC(=O)N/C=C/c1c(OC)ccc2ccccc12	10.1016/j.bmcl.2012.11.069
	11810280	214710	0	None	-16	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	8	1	3	4.5	CCCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL96859	214710	0	None	-16	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	8	1	3	4.5	CCCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	10091075	24053	0	None	8	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	378	11	1	3	5.2	CCCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL125705	24053	0	None	8	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	378	11	1	3	5.2	CCCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	52918078	67528	0	None	-11	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	247	5	1	4	1.6	CCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	CHEMBL1760946	67528	0	None	-11	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	247	5	1	4	1.6	CCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	23658146	163897	1	None	-10	3	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4074895	163897	1	None	-10	3	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	56664925	71224	0	None	53	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	498	17	2	6	3.8	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813321	71224	0	None	53	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	498	17	2	6	3.8	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	137631636	163387	0	None	-7	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	308	4	1	2	3.4	CCC(=O)NC[C@@H]1CN(C)c2ccccc2[C@@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
	CHEMBL4068887	163387	0	None	-7	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	308	4	1	2	3.4	CCC(=O)NC[C@@H]1CN(C)c2ccccc2[C@@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
	85880795	117645	0	None	12	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	319	9	1	3	4.0	CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2	10.1021/jm401343c
	CHEMBL3260984	117645	0	None	12	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	319	9	1	3	4.0	CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2	10.1021/jm401343c
	18360658	15662	0	None	4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	518	13	2	5	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097497	15662	0	None	4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	518	13	2	5	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	10015475	23535	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	2.8	CCC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124362	23535	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	2.8	CCC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
	44272444	74721	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	303	6	3	3	3.0	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)NCC)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL19109	74721	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	303	6	3	3	3.0	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)NCC)c2O1	10.1016/j.bmcl.2003.12.052
	137648419	164618	0	None	-15	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	293	4	1	1	3.9	CCC(=O)NC[C@@H]1CCc2ccccc2[C@@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
	CHEMBL4083618	164618	0	None	-15	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	293	4	1	1	3.9	CCC(=O)NC[C@@H]1CCc2ccccc2[C@@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
	10926138	214756	0	None	-57	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	349	8	1	3	4.3	C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL97186	214756	0	None	-57	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	349	8	1	3	4.3	C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	44429447	94521	0	None	-5	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	310	4	2	2	2.6	COc1cc(Br)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
	CHEMBL233728	94521	0	None	-5	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	310	4	2	2	2.6	COc1cc(Br)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
	139451784	192174	0	None	6	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	317	7	1	5	2.4	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1	10.1021/acs.jmedchem.0c00627
	CHEMBL4860729	192174	0	None	6	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	317	7	1	5	2.4	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1	10.1021/acs.jmedchem.0c00627
	49865149	22605	2	None	2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC(C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1222986	22605	2	None	2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC(C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	25270146	37466	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	262	5	1	3	2.2	CCCC(=O)N[C@H]1CCN(c2cccc(OC)c2)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL139497	37466	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	262	5	1	3	2.2	CCCC(=O)N[C@H]1CCN(c2cccc(OC)c2)C1	10.1016/j.bmcl.2003.09.030
	15453093	93186	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	255	3	1	2	2.8	COc1ccc2ccccc2c1[C@@H]1C[C@H]1NC(C)=O	10.1016/j.bmcl.2012.11.069
	CHEMBL2314252	93186	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	255	3	1	2	2.8	COc1ccc2ccccc2c1[C@@H]1C[C@H]1NC(C)=O	10.1016/j.bmcl.2012.11.069
	10022490	73831	0	None	22	2	Human	8.4	pKi	=	8.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	377	10	1	2	5.7	CC(C)C(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL187186	73831	0	None	22	2	Human	8.4	pKi	=	8.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	377	10	1	2	5.7	CC(C)C(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	49865324	22673	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NC[C@H](C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223198	22673	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NC[C@H](C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	9860296	35990	0	None	8	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	272	3	1	3	1.7	O=C(N[C@@H]1CCN(c2cccc3c2CCO3)C1)C1CC1	10.1016/j.bmcl.2003.09.030
	CHEMBL138228	35990	0	None	8	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	272	3	1	3	1.7	O=C(N[C@@H]1CCN(c2cccc3c2CCO3)C1)C1CC1	10.1016/j.bmcl.2003.09.030
	18466111	26617	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL130214	26617	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	1362	10210	22	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	9870523	10210	22	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	CHEMBL429392	10210	22	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	56653120	117646	0	None	12	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	336	8	2	2	3.9	CC(=O)NCCc1c[nH]c2ccc(OCCCc3ccccc3)cc12	10.1021/jm401343c
	CHEMBL3260985	117646	0	None	12	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	336	8	2	2	3.9	CC(=O)NCCc1c[nH]c2ccc(OCCCc3ccccc3)cc12	10.1021/jm401343c
	56681902	71226	0	None	10	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	554	21	2	6	5.4	CC(=O)NCCN(C)c1cccc(OCCCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813323	71226	0	None	10	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	554	21	2	6	5.4	CC(=O)NCCN(C)c1cccc(OCCCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	22718532	23555	0	None	-7	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	218	4	1	3	1.9	CC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124488	23555	0	None	-7	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	218	4	1	3	1.9	CC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
	9881917	103816	0	None	-44	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	271	5	1	3	3.8	CCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL266970	103816	0	None	-44	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	271	5	1	3	3.8	CCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	25210000	196273	0	None	-11	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	408	7	2	5	3.3	COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL513933	196273	0	None	-11	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	408	7	2	5	3.3	COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	25022442	196338	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1021/jm800974d
	CHEMBL514413	196338	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1021/jm800974d
	11681201	147854	0	None	-2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	314	5	1	3	3.5	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1	10.1021/jm0512544
	CHEMBL382555	147854	0	None	-2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	314	5	1	3	3.5	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1	10.1021/jm0512544
	162663385	188777	0	None	-2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	271	5	1	4	1.7	COc1ccc2cnnc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4780509	188777	0	None	-2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	271	5	1	4	1.7	COc1ccc2cnnc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2020.112078
	122188229	129924	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	249	3	3	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612460	129924	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	249	3	3	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	11573203	147856	0	None	-2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	312	5	1	3	3.1	COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCC1)cn2C	10.1021/jm0512544
	CHEMBL382579	147856	0	None	-2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	312	5	1	3	3.1	COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCC1)cn2C	10.1021/jm0512544
	10991315	215074	0	None	-23	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	336	7	1	3	4.1	CCC(=O)NCCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
	CHEMBL99001	215074	0	None	-23	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	336	7	1	3	4.1	CCC(=O)NCCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
	25210000	196273	0	None	-11	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	408	7	2	5	3.3	COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL513933	196273	0	None	-11	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	408	7	2	5	3.3	COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	145974583	171269	0	None	4	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	279	9	2	4	1.4	CC(=O)NCCN(C)c1cccc(OCCCCN)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4214348	171269	0	None	4	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	279	9	2	4	1.4	CC(=O)NCCN(C)c1cccc(OCCCCN)c1	10.1021/acs.jmedchem.8b00893
	44264705	211240	1	None	-79	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	284	6	2	3	4.2	CCCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7229	211240	1	None	-79	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	284	6	2	3	4.2	CCCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	127040022	144729	0	None	-6	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	410	5	1	4	5.5	COc1ccc2oc(-c3c4ccccc4cc4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3764063	144729	0	None	-6	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	410	5	1	4	5.5	COc1ccc2oc(-c3c4ccccc4cc4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	9819843	214917	0	None	-20	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	8	1	3	4.3	COc1ccc2oc(CCCc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL98074	214917	0	None	-20	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	8	1	3	4.3	COc1ccc2oc(CCCc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	145978811	170639	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	531	16	2	5	6.4	CC(=O)NCCN(C)c1cccc(OCCCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4206642	170639	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	531	16	2	5	6.4	CC(=O)NCCN(C)c1cccc(OCCCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	137655489	165754	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	245	4	2	3	1.5	COc1cnc2cccc(CCNC(N)=O)c2c1	10.1016/j.ejmech.2016.12.013
	CHEMBL4096197	165754	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	245	4	2	3	1.5	COc1cnc2cccc(CCNC(N)=O)c2c1	10.1016/j.ejmech.2016.12.013
	25022442	196338	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1016/j.bmc.2009.04.068
	CHEMBL514413	196338	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1016/j.bmc.2009.04.068
	11058163	214993	0	None	-22	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	386	5	1	3	4.1	COc1cccc2c1c(Br)c(CNC(C)=O)n2Cc1ccccc1	10.1021/jm001125h
	CHEMBL98520	214993	0	None	-22	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	386	5	1	3	4.1	COc1cccc2c1c(Br)c(CNC(C)=O)n2Cc1ccccc1	10.1021/jm001125h
	49865423	22730	2	None	-4	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)NC(C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223345	22730	2	None	-4	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)NC(C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
	25022442	196338	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1016/j.bmc.2008.07.012
	CHEMBL514413	196338	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1016/j.bmc.2008.07.012
	145982333	173336	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4279639	173336	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL3109563	217870	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 mins	ChEMBL		None	None	None		COc1ccc2c(c1)c(CCNC(C)=O)c1n2[B-](F)(F)[N+]2=C(C)C=C(C)C2=C1	10.1021/ml4004155
	129776	6930	6	None	-128	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1016/j.ejmech.2019.111847
	1364	6930	6	None	-128	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1016/j.ejmech.2019.111847
	CHEMBL339105	6930	6	None	-128	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1016/j.ejmech.2019.111847
	129776	6930	6	None	-128	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1021/jm401343c
	1364	6930	6	None	-128	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1021/jm401343c
	CHEMBL339105	6930	6	None	-128	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1021/jm401343c
	71508235	93850	0	None	-95	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	327	8	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326203	93850	0	None	-95	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	327	8	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	25022442	196338	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1021/jm800974d
	CHEMBL514413	196338	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1021/jm800974d
	162649850	186917	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4748822	186917	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	24750194	96723	0	None	-87	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	324	7	1	3	3.8	COc1cccc(N(CCNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm700957j
	CHEMBL238049	96723	0	None	-87	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	324	7	1	3	3.8	COc1cccc(N(CCNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm700957j
	122188353	129946	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	322	6	1	2	3.9	CCC(=O)NCCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612610	129946	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	322	6	1	2	3.9	CCC(=O)NCCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	20590664	130450	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	390	9	2	2	5.4	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL362097	130450	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	390	9	2	2	5.4	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	44429451	155991	0	None	-15	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	352	6	1	3	3.4	CCCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL394406	155991	0	None	-15	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	352	6	1	3	3.4	CCCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	11002150	114330	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	334	6	1	3	3.7	COc1cccc2c1cc(CCNC(=O)C1CC1)n2-c1ccccc1	10.1021/jm001125h
	CHEMBL318871	114330	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	334	6	1	3	3.7	COc1cccc2c1cc(CCNC(=O)C1CC1)n2-c1ccccc1	10.1021/jm001125h
	44349270	119869	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	286	6	1	3	3.4	CC(C)c1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL331317	119869	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	286	6	1	3	3.4	CC(C)c1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	44264843	211626	0	None	-4	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	300	5	1	4	4.0	CCOC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7556	211626	0	None	-4	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	300	5	1	4	4.0	CCOC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	137640407	163522	0	None	-67	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	270	5	1	3	2.5	COc1ccc2cccc(CCC(=O)NC3CC3)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4070527	163522	0	None	-67	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	270	5	1	3	2.5	COc1ccc2cccc(CCC(=O)NC3CC3)c2n1	10.1016/j.ejmech.2016.12.013
	11638009	172542	0	None	-7	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	5	1	3	3.1	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	CHEMBL424693	172542	0	None	-7	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	5	1	3	3.1	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	44587356	200163	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	423	8	3	5	2.8	COc1ccc2c(c1)CC(CO)N2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2008.07.012
	CHEMBL525374	200163	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	423	8	3	5	2.8	COc1ccc2c(c1)CC(CO)N2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2008.07.012
	168296374	199297	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	CHEMBL5209359	199297	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	145966403	170987	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	497	13	2	6	4.9	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4210884	170987	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	497	13	2	6	4.9	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1	10.1021/acs.jmedchem.8b00893
	44349294	25325	1	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	323	6	2	3	3.7	CCNC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL127576	25325	1	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	323	6	2	3	3.7	CCNC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	23658143	163156	1	None	-6	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4066279	163156	1	None	-6	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	49865375	22704	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC[C@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223278	22704	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC[C@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	127038131	143429	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	363	9	1	3	4.4	CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3740052	143429	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	363	9	1	3	4.4	CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	122178509	128106	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580919	128106	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	122178509	128106	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	CHEMBL3580919	128106	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	127038131	143429	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	363	9	1	3	4.4	CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3740052	143429	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	363	9	1	3	4.4	CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	49865373	22702	2	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OCC(C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223276	22702	2	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OCC(C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	44264861	211923	0	None	-74	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	310	5	1	3	4.1	CCCC(=O)Nc1ccc(N(C)c2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7807	211923	0	None	-74	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	310	5	1	3	4.1	CCCC(=O)Nc1ccc(N(C)c2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
	16094587	90037	3	None	-72	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	297	7	1	2	3.7	CCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
	CHEMBL218774	90037	3	None	-72	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	297	7	1	2	3.7	CCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
	16094592	90060	1	None	-6	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.4	CC(=O)NC/C(=C/c1ccccc1)c1ccccc1	10.1021/jm060850a
	CHEMBL218926	90060	1	None	-6	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.4	CC(=O)NC/C(=C/c1ccccc1)c1ccccc1	10.1021/jm060850a
	49865267	22648	2	None	-7	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1ccccc1SCCNC(C)=O	10.1016/j.bmc.2010.06.100
	CHEMBL1223127	22648	2	None	-7	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1ccccc1SCCNC(C)=O	10.1016/j.bmc.2010.06.100
	49865374	22703	0	None	-7	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC[C@@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223277	22703	0	None	-7	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC[C@@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	122188235	129930	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	308	5	1	2	3.5	CCC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612467	129930	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	308	5	1	2	3.5	CCC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	145971692	169799	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	264	3	0	3	3.8	O=c1ccc2ccc(O/C=C/c3ccccc3)cc2o1	10.1021/acs.jnatprod.7b00853
	CHEMBL4175759	169799	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	264	3	0	3	3.8	O=c1ccc2ccc(O/C=C/c3ccccc3)cc2o1	10.1021/acs.jnatprod.7b00853
	16743125	99078	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	296	5	1	2	3.4	O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CCC1	10.1016/j.ejmech.2007.01.005
	CHEMBL242786	99078	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	296	5	1	2	3.4	O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CCC1	10.1016/j.ejmech.2007.01.005
	49865425	22732	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)N[C@@H](C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223347	22732	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)N[C@@H](C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
	4207624	22627	37	None	-5	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1ccccc1OCCNC(C)=O	10.1016/j.bmc.2010.06.100
	CHEMBL1223055	22627	37	None	-5	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1ccccc1OCCNC(C)=O	10.1016/j.bmc.2010.06.100
	46885230	14965	0	None	-8	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	223	5	2	3	1.5	COc1ccc(O)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1092062	14965	0	None	-8	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	223	5	2	3	1.5	COc1ccc(O)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	25210131	182094	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	CHEMBL457352	182094	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	25210131	182094	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	CHEMBL457352	182094	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	71508232	93848	0	None	-524	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	351	7	1	3	3.6	CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326200	93848	0	None	-524	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	351	7	1	3	3.6	CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	44579296	193573	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	376	6	2	3	4.2	COc1ccc2cc(-c3cccc(NC(C)=O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL489170	193573	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	376	6	2	3	4.2	COc1ccc2cc(-c3cccc(NC(C)=O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	145969866	171620	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	546	15	3	6	4.8	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4218897	171620	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	546	15	3	6	4.8	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)c1	10.1021/acs.jmedchem.8b00893
	56662798	71229	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	554	21	2	6	5.4	COc1cccc(N(CCCCCCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813326	71229	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	554	21	2	6	5.4	COc1cccc(N(CCCCCCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1	10.1016/j.bmc.2011.06.063
	10704742	114038	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1cccc2cc(CCNC(C)=O)[nH]c12	10.1021/jm001125h
	CHEMBL316952	114038	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1cccc2cc(CCNC(C)=O)[nH]c12	10.1021/jm001125h
	10704742	114038	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1cccc2cc(CCNC(C)=O)[nH]c12	10.1021/jm970721h
	CHEMBL316952	114038	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1cccc2cc(CCNC(C)=O)[nH]c12	10.1021/jm970721h
	13250272	22646	17	None	-11	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	195	4	1	2	1.9	CC(=O)NCCSc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223125	22646	17	None	-11	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	195	4	1	2	1.9	CC(=O)NCCSc1ccccc1	10.1016/j.bmc.2010.06.100
	44579261	193758	0	None	-87	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	363	6	2	3	3.9	COc1ccc2cc(-c3cccc(C(=O)O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL490594	193758	0	None	-87	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	363	6	2	3	3.9	COc1ccc2cc(-c3cccc(C(=O)O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	44424026	149114	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	546	17	4	4	5.8	COc1ccc2[nH]cc(CCNC(=O)CCCCCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL388591	149114	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	546	17	4	4	5.8	COc1ccc2[nH]cc(CCNC(=O)CCCCCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1016/j.bmc.2007.03.080
	10709646	214612	0	None	-10	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	304	3	1	2	3.5	CC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
	CHEMBL9634	214612	0	None	-10	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	304	3	1	2	3.5	CC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
	11219713	132621	0	None	-4	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	279	3	1	1	3.4	CC(=O)NCCC1Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
	CHEMBL364835	132621	0	None	-4	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	279	3	1	1	3.4	CC(=O)NCCC1Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
	16094579	87617	5	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	267	6	1	1	3.3	CCC(=O)NCCc1cccc(Cc2ccccc2)c1	10.1021/jm060850a
	CHEMBL215252	87617	5	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	267	6	1	1	3.3	CCC(=O)NCCc1cccc(Cc2ccccc2)c1	10.1021/jm060850a
	44394338	128821	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	405	8	2	3	4.9	CCNC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	CHEMBL359561	128821	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	405	8	2	3	4.9	CCNC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	71508234	7492	0	None	-38	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	7924	7492	0	None	-38	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	CHEMBL2326202	7492	0	None	-38	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	10638747	215146	0	None	-11	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	310	4	2	2	2.6	COc1ccc2c(Br)c(CCNC(C)=O)[nH]c2c1	10.1021/jm001125h
	CHEMBL99512	215146	0	None	-11	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	310	4	2	2	2.6	COc1ccc2c(Br)c(CCNC(C)=O)[nH]c2c1	10.1021/jm001125h
	10638747	215146	0	None	-11	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	310	4	2	2	2.6	COc1ccc2c(Br)c(CCNC(C)=O)[nH]c2c1	10.1021/jm970721h
	CHEMBL99512	215146	0	None	-11	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	310	4	2	2	2.6	COc1ccc2c(Br)c(CCNC(C)=O)[nH]c2c1	10.1021/jm970721h
	44389839	71375	0	None	10	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	379	10	1	2	5.1	CC(C)C(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL181687	71375	0	None	10	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	379	10	1	2	5.1	CC(C)C(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	12071674	130721	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	351	9	1	2	4.5	CC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL362849	130721	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	351	9	1	2	4.5	CC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	145979282	173454	0	None	-16	3	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4281915	173454	0	None	-16	3	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145988801	173825	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	283	4	1	2	3.4	COc1ccc2ccc3c(c2c1)C(CCNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4288925	173825	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	283	4	1	2	3.4	COc1ccc2ccc3c(c2c1)C(CCNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	145986700	173998	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	328	4	2	2	3.5	CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4292109	173998	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	328	4	2	2	3.5	CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137650826	164284	0	None	-10	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4079699	164284	0	None	-10	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	46888491	15443	0	None	20	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	501	13	3	4	4.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4[nH]cc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095522	15443	0	None	20	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	501	13	3	4	4.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4[nH]cc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	10522675	11110	0	None	-20	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	6	1	3	4.3	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1021/jm980684+
	CHEMBL10099	11110	0	None	-20	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	6	1	3	4.3	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1021/jm980684+
	10522675	11110	0	None	-20	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	362	6	1	3	4.3	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1016/j.ejmech.2019.111847
	CHEMBL10099	11110	0	None	-20	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	362	6	1	3	4.3	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1016/j.ejmech.2019.111847
	16656789	95326	0	None	-63	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1cccc(N(CCNC(C)=O)c2ccccc2)c1	10.1021/jm700957j
	CHEMBL235327	95326	0	None	-63	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1cccc(N(CCNC(C)=O)c2ccccc2)c1	10.1021/jm700957j
	24750071	105696	0	None	-39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	312	8	1	3	3.8	CCCC(=O)NCCN(c1ccccc1)c1cccc(OC)c1	10.1021/jm700957j
	CHEMBL279401	105696	0	None	-39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	312	8	1	3	3.8	CCCC(=O)NCCN(c1ccccc1)c1cccc(OC)c1	10.1021/jm700957j
	44429448	94522	0	None	-7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	324	5	2	2	3.0	CCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL233729	94522	0	None	-7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	324	5	2	2	3.0	CCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	49865319	22668	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NCC(C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223193	22668	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NCC(C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	10704399	28279	0	None	-8	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	225	2	1	1	2.6	CC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL131602	28279	0	None	-8	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	225	2	1	1	2.6	CC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	11652196	145091	0	None	-9	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	288	6	1	3	3.2	CCCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	CHEMBL377101	145091	0	None	-9	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	288	6	1	3	3.2	CCCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	10495702	212014	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	317	8	2	4	2.3	CCC(=O)NCCc1c(OCCO)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL78751	212014	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	317	8	2	4	2.3	CCC(=O)NCCc1c(OCCO)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	10729569	123334	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	253	4	1	1	3.4	CCC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL336333	123334	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	253	4	1	1	3.4	CCC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	9840647	104997	0	None	-25	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	5	1	3	3.7	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)Cc1ccccc1-2	10.1021/jm980684+
	CHEMBL274317	104997	0	None	-25	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	5	1	3	3.7	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)Cc1ccccc1-2	10.1021/jm980684+
	44358276	125750	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	289	4	2	3	1.9	CCCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL342393	125750	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	289	4	2	3	1.9	CCCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	57781240	192767	0	None	-36	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	334	5	1	3	4.0	CC(=O)NCCC1CCc2ccc3nc(Cc4ccccc4)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4870108	192767	0	None	-36	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	334	5	1	3	4.0	CC(=O)NCCC1CCc2ccc3nc(Cc4ccccc4)oc3c21	10.1021/acs.jmedchem.0c01836
	1350	8771	0	None	-95	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm980684+
	4172142	8771	0	None	-95	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm980684+
	CHEMBL10009	8771	0	None	-95	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm980684+
	1350	8771	0	None	-95	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cells	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm401343c
	4172142	8771	0	None	-95	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cells	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm401343c
	CHEMBL10009	8771	0	None	-95	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cells	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm401343c
	44348996	23979	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	272	6	1	3	2.8	CCc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL125642	23979	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	272	6	1	3	2.8	CCc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	127029516	144412	0	None	-6	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3occ(CNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758225	144412	0	None	-6	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3occ(CNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	23642307	165674	1	None	-8	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4095334	165674	1	None	-8	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	145976009	170311	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	541	15	3	4	7.0	CC(=O)NCCc1c[nH]c2ccc(OCCCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12	10.1021/acs.jmedchem.8b00893
	CHEMBL4202816	170311	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	541	15	3	4	7.0	CC(=O)NCCc1c[nH]c2ccc(OCCCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12	10.1021/acs.jmedchem.8b00893
	44272334	74409	0	None	-17	2	Human	8.3	pKi	=	8.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	6	2	3	3.5	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL19050	74409	0	None	-17	2	Human	8.3	pKi	=	8.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	6	2	3	3.5	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1	10.1016/j.bmcl.2003.12.052
	44272430	173711	0	None	-15	2	Human	8.3	pKi	=	8.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	288	5	2	3	3.1	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL428692	173711	0	None	-15	2	Human	8.3	pKi	=	8.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	288	5	2	3	3.1	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	11550834	146322	0	None	-4	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	5	1	3	2.8	CCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	CHEMBL379616	146322	0	None	-4	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	5	1	3	2.8	CCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	22718555	23361	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	6	1	3	3.7	CC(C)C(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL123973	23361	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	6	1	3	3.7	CC(C)C(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	22718530	24719	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	294	5	1	3	3.6	CC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL126005	24719	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	294	5	1	3	3.6	CC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	19703063	35688	1	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.bmcl.2011.02.097
	CHEMBL137969	35688	1	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.bmcl.2011.02.097
	19703063	35688	1	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.ejmech.2016.01.008
	CHEMBL137969	35688	1	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.ejmech.2016.01.008
	1347	6950	56	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10.1016/j.ejmech.2019.111847
	1864	6950	56	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10.1016/j.ejmech.2019.111847
	CHEMBL127421	6950	56	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10.1016/j.ejmech.2019.111847
	1353	10208	5	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	9998187	10208	5	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	CHEMBL33549	10208	5	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	1353	10208	5	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm401343c
	9998187	10208	5	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm401343c
	CHEMBL33549	10208	5	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm401343c
	25209861	181998	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	8	2	3	4.6	CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	CHEMBL457138	181998	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	8	2	3	4.6	CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	25210133	196340	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.7	COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL514427	196340	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.7	COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	44436051	158142	6	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1cccc(OCCNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL396132	158142	6	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1cccc(OCCNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	1353	10208	5	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm048956y
	9998187	10208	5	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm048956y
	CHEMBL33549	10208	5	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm048956y
	46885285	14939	0	None	-186	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	265	8	1	3	2.6	CCCOc1ccc(OC)cc1CCCNC(C)=O	10.1016/j.bmcl.2010.02.084
	CHEMBL1091894	14939	0	None	-186	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	265	8	1	3	2.6	CCCOc1ccc(OC)cc1CCCNC(C)=O	10.1016/j.bmcl.2010.02.084
	10657206	126467	2	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	2.2	CCC(=O)NCc1cc2c(OC)cccc2[nH]1	10.1021/jm001125h
	CHEMBL34728	126467	2	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	2.2	CCC(=O)NCc1cc2c(OC)cccc2[nH]1	10.1021/jm001125h
	10657206	126467	2	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	2.2	CCC(=O)NCc1cc2c(OC)cccc2[nH]1	10.1021/jm970721h
	CHEMBL34728	126467	2	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	2.2	CCC(=O)NCc1cc2c(OC)cccc2[nH]1	10.1021/jm970721h
	44264904	212400	0	None	-57	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	295	5	1	2	4.0	CCCC(=O)Nc1ccc(Cc2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL8169	212400	0	None	-57	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	295	5	1	2	4.0	CCCC(=O)Nc1ccc(Cc2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
	25209861	181998	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	8	2	3	4.6	CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	CHEMBL457138	181998	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	8	2	3	4.6	CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	25210133	196340	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.7	COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL514427	196340	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.7	COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	16743295	99964	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	284	6	1	2	3.4	CCCC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
	CHEMBL244472	99964	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	284	6	1	2	3.4	CCCC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
	5151463	90108	12	None	-29	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	253	5	1	1	3.3	CC(=O)NCCC(c1ccccc1)c1ccccc1	10.1021/jm060850a
	CHEMBL219177	90108	12	None	-29	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	253	5	1	1	3.3	CC(=O)NCCC(c1ccccc1)c1ccccc1	10.1021/jm060850a
	10545399	212291	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	344	9	1	4	2.9	CCC(=O)NCCc1c(OCCN(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL80792	212291	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	344	9	1	4	2.9	CCC(=O)NCCc1c(OCCN(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	44394556	131003	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	402	8	1	3	5.1	O=C(N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1)C1CC1	10.1016/j.bmcl.2004.07.055
	CHEMBL363441	131003	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	402	8	1	3	5.1	O=C(N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1)C1CC1	10.1016/j.bmcl.2004.07.055
	56661512	71221	0	None	23	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	470	15	2	6	3.1	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813319	71221	0	None	23	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	470	15	2	6	3.1	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	10959837	214357	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	379	10	1	3	5.3	CCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL94919	214357	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	379	10	1	3	5.3	CCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	49865147	22602	2	None	-3	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1ccc(OC(C)CNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
	CHEMBL1222983	22602	2	None	-3	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1ccc(OC(C)CNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
	127025788	144545	0	None	-53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	300	3	2	3	3.2	CNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759372	144545	0	None	-53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	300	3	2	3	3.2	CNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	130400672	163775	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	204	2	2	2	1.4	CC(=O)NCC1CNc2ccccc2C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4073210	163775	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	204	2	2	2	1.4	CC(=O)NCC1CNc2ccccc2C1	10.1021/acs.jmedchem.8b00359
	10595585	105322	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	374	5	1	3	4.3	COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCc2ccccc2-1	10.1021/jm980684+
	CHEMBL276490	105322	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	374	5	1	3	4.3	COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCc2ccccc2-1	10.1021/jm980684+
	44349362	23346	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	286	7	1	3	3.2	CCCc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL123899	23346	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	286	7	1	3	3.2	CCCc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	46884553	15069	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1cccc(COc2ccc(OC)cc2CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1092646	15069	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1cccc(COc2ccc(OC)cc2CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	910172	44503	24	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	252	3	0	3	3.4	O=c1ccc2ccc(OCc3ccccc3)cc2o1	10.1021/acs.jnatprod.7b00853
	CHEMBL145781	44503	24	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	252	3	0	3	3.4	O=c1ccc2ccc(OCc3ccccc3)cc2o1	10.1021/acs.jnatprod.7b00853
	145965883	170861	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	307	11	2	4	2.2	CC(=O)NCCN(C)c1cccc(OCCCCCCN)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4209446	170861	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	307	11	2	4	2.2	CC(=O)NCCN(C)c1cccc(OCCCCCCN)c1	10.1021/acs.jmedchem.8b00893
	122188236	129931	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.1	CC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612468	129931	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.1	CC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	122188237	129932	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.1	CC(=O)NC[C@H]1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612469	129932	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.1	CC(=O)NC[C@H]1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	10712600	11130	0	None	-48	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	346	5	1	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1	10.1021/jm980684+
	CHEMBL10110	11130	0	None	-48	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	346	5	1	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1	10.1021/jm980684+
	11602301	83476	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	326	5	1	3	3.5	COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCCC1)cn2C	10.1021/jm0512544
	CHEMBL206471	83476	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	326	5	1	3	3.5	COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCCC1)cn2C	10.1021/jm0512544
	10950593	118298	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	459	6	1	3	5.7	COc1ccc2oc(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL327864	118298	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	459	6	1	3	5.7	COc1ccc2oc(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	164946945	197008	1	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5174929	197008	1	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	49865378	22707	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC[C@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223281	22707	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC[C@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	11501012	84017	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	340	5	1	3	3.9	COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCCC1)cn2C	10.1021/jm0512544
	CHEMBL207959	84017	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	340	5	1	3	3.9	COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCCC1)cn2C	10.1021/jm0512544
	49865203	22621	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(O[C@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223049	22621	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(O[C@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	122188226	129922	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	263	4	3	3	1.7	CCNC(=O)NCC1CCc2c(cccc2OC)N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612457	129922	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	263	4	3	3	1.7	CCNC(=O)NCC1CCc2c(cccc2OC)N1	10.1021/acs.jmedchem.5b01066
	11616210	146236	0	None	-6	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	4	1	3	2.7	COc1ccc2c(c1)c(C1(CNC(C)=O)CCC1)cn2C	10.1021/jm0512544
	CHEMBL379413	146236	0	None	-6	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	4	1	3	2.7	COc1ccc2c(c1)c(C1(CNC(C)=O)CCC1)cn2C	10.1021/jm0512544
	44347098	23188	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	344	5	1	4	2.7	CCCCC(=O)n1c(OC)cc2c1=C(CN)C1CCCCC(C)C1C=2	10.1021/jm970721h
	CHEMBL123119	23188	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	344	5	1	4	2.7	CCCCC(=O)n1c(OC)cc2c1=C(CN)C1CCCCC(C)C1C=2	10.1021/jm970721h
	CHEMBL3109561	217868	0	None	6	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 mins	ChEMBL		None	None	None		COc1ccc(C2=[N+]3C(=Cc4c(CCNC(C)=O)c5cc(OC)ccc5n4[B-]3(F)F)C=C2)cc1	10.1021/ml4004155
	11065731	108658	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1cc([N+](=O)[O-])c2[nH]cc(CCNC(C)=O)c2c1	10.1021/jm011053+
	CHEMBL300729	108658	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1cc([N+](=O)[O-])c2[nH]cc(CCNC(C)=O)c2c1	10.1021/jm011053+
	44358035	36737	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	260	3	1	3	1.7	CCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL138848	36737	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	260	3	1	3	1.7	CCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	44579163	188908	0	None	-53	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	362	6	1	3	4.3	COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL478217	188908	0	None	-53	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	362	6	1	3	4.3	COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	44349329	25320	1	None	-13	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	289	7	2	3	3.0	CCCc1nc2cccc(CCCNC(=O)NCC)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL127565	25320	1	None	-13	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	289	7	2	3	3.0	CCCc1nc2cccc(CCCNC(=O)NCC)c2o1	10.1016/j.bmcl.2004.04.082
	11500596	145457	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	312	5	2	2	3.5	COc1ccc2[nH]cc(C3(CNC(=O)C4CCC4)CCC3)c2c1	10.1021/jm0512544
	CHEMBL377809	145457	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	312	5	2	2	3.5	COc1ccc2[nH]cc(C3(CNC(=O)C4CCC4)CCC3)c2c1	10.1021/jm0512544
	122188230	129925	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	277	4	2	3	1.8	CCNC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612461	129925	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	277	4	2	3	1.8	CCNC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	10424693	116420	1	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	297	4	1	2	3.1	COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1	10.1039/C5MD00190K
	CHEMBL322339	116420	1	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	297	4	1	2	3.1	COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1	10.1039/C5MD00190K
	127038129	143650	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	311	5	1	2	3.3	COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1	10.1039/C5MD00190K
	CHEMBL3742090	143650	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	311	5	1	2	3.3	COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1	10.1039/C5MD00190K
	86273226	128096	0	None	-5	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	256	5	2	2	1.9	C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580908	128096	0	None	-5	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	256	5	2	2	1.9	C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	145983929	173200	0	None	-6	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	4	1	3	2.8	COc1ccc2ccc3c(c2n1)C(CCNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4277185	173200	0	None	-6	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	4	1	3	2.8	COc1ccc2ccc3c(c2n1)C(CCNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	145993566	174150	0	None	-25	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	312	5	2	2	3.6	CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4294790	174150	0	None	-25	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	312	5	2	2	3.6	CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137642160	165171	0	None	-165	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	308	5	1	5	1.3	COc1ccc2cccc(CCC(=O)NS(C)(=O)=O)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4089965	165171	0	None	-165	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	308	5	1	5	1.3	COc1ccc2cccc(CCC(=O)NS(C)(=O)=O)c2n1	10.1016/j.ejmech.2016.12.013
	127038129	143650	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	311	5	1	2	3.3	COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1	10.1039/C5MD00190K
	CHEMBL3742090	143650	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	311	5	1	2	3.3	COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1	10.1039/C5MD00190K
	44272431	105633	0	None	-4	2	Human	8.3	pKi	=	8.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	274	4	2	3	2.7	CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL278922	105633	0	None	-4	2	Human	8.3	pKi	=	8.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	274	4	2	3	2.7	CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	16750569	94137	0	None	-14	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	338	6	2	2	3.4	CCCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL233308	94137	0	None	-14	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	338	6	2	2	3.4	CCCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	9888609	15664	0	None	46	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO-K1 cells after 2 hrsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO-K1 cells after 2 hrs	ChEMBL	424	7	2	2	5.0	CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1039/C5MD00190K
	CHEMBL1097525	15664	0	None	46	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO-K1 cells after 2 hrsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO-K1 cells after 2 hrs	ChEMBL	424	7	2	2	5.0	CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1039/C5MD00190K
	9888609	15664	0	None	46	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	424	7	2	2	5.0	CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm401343c
	CHEMBL1097525	15664	0	None	46	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	424	7	2	2	5.0	CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm401343c
	24750070	160332	4	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	208	5	2	3	1.2	COc1cccc(NCCNC(C)=O)c1	10.1021/jm700957j
	CHEMBL398017	160332	4	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	208	5	2	3	1.2	COc1cccc(NCCNC(C)=O)c1	10.1021/jm700957j
	122188231	129926	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	247	3	2	2	1.8	CCNC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612462	129926	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	247	3	2	2	1.8	CCNC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	10882307	214253	0	None	-15	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	338	6	2	3	3.5	CNC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL94301	214253	0	None	-15	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	338	6	2	3	3.5	CNC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	49865318	22667	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(S[C@@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223192	22667	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(S[C@@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	11644612	85073	0	None	-9	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
	CHEMBL210791	85073	0	None	-9	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
	90666306	116160	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12	10.1039/C1MD00149C
	CHEMBL3219327	116160	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12	10.1039/C1MD00149C
	127025784	144511	0	None	-8	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759084	144511	0	None	-8	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1	10.1016/j.ejmech.2015.12.047
	10424693	116420	1	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	297	4	1	2	3.1	COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1	10.1039/C5MD00190K
	CHEMBL322339	116420	1	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	297	4	1	2	3.1	COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1	10.1039/C5MD00190K
	25209998	196521	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	393	7	2	4	3.4	COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1021/jm800974d
	CHEMBL515856	196521	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	393	7	2	4	3.4	COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1021/jm800974d
	49865206	22625	1	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(S[C@@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223053	22625	1	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(S[C@@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	122188349	129943	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	246	4	1	2	2.4	CCCN1c2ccccc2CCC1CNC(C)=O	10.1021/acs.jmedchem.5b01066
	CHEMBL3612606	129943	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	246	4	1	2	2.4	CCCN1c2ccccc2CCC1CNC(C)=O	10.1021/acs.jmedchem.5b01066
	25209998	196521	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	393	7	2	4	3.4	COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1021/jm800974d
	CHEMBL515856	196521	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	393	7	2	4	3.4	COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1021/jm800974d
	23658144	164958	1	None	-6	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4087633	164958	1	None	-6	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	10712733	215221	0	None	-48	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	5	1	3	3.9	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1021/jm980684+
	CHEMBL9997	215221	0	None	-48	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	5	1	3	3.9	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1021/jm980684+
	10399579	210762	0	None	-4	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	244	4	1	3	1.9	COc1ccc2nccc(CCNC(C)=O)c2c1	10.1016/S0960-894X(97)00392-2
	CHEMBL69521	210762	0	None	-4	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	244	4	1	3	1.9	COc1ccc2nccc(CCNC(C)=O)c2c1	10.1016/S0960-894X(97)00392-2
	12985489	197015	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2cc(-c3ccccc3CO)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL517502	197015	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2cc(-c3ccccc3CO)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	44349258	23689	1	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	261	5	2	3	2.4	CCNC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL125226	23689	1	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	261	5	2	3	2.4	CCNC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	10903463	215143	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	324	5	2	2	3.0	CCC(=O)NCCc1[nH]c2cccc(OC)c2c1Br	10.1021/jm001125h
	CHEMBL99502	215143	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	324	5	2	2	3.0	CCC(=O)NCCc1[nH]c2cccc(OC)c2c1Br	10.1021/jm001125h
	24750069	157262	0	None	-66	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	298	7	1	3	2.8	COc1cccc(N(CCNC(C)=O)Cc2ccccc2)c1	10.1021/jm700957j
	CHEMBL395437	157262	0	None	-66	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	298	7	1	3	2.8	COc1cccc(N(CCNC(C)=O)Cc2ccccc2)c1	10.1021/jm700957j
	12985491	193759	0	None	-91	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	411	6	1	2	5.1	COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL490595	193759	0	None	-91	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	411	6	1	2	5.1	COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	118712359	120927	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	350	3	1	4	3.4	O=C(CN1CCCC2Cc3cc4c(cc3C21)OCO4)Nc1ccccc1	10.1016/j.ejmech.2014.09.038
	CHEMBL3329376	120927	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	350	3	1	4	3.4	O=C(CN1CCCC2Cc3cc4c(cc3C21)OCO4)Nc1ccccc1	10.1016/j.ejmech.2014.09.038
	162649247	186854	0	None	-10	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	351	6	1	5	3.0	COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1	10.1016/j.ejmech.2020.112078
	CHEMBL4747996	186854	0	None	-10	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	351	6	1	5	3.0	COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1	10.1016/j.ejmech.2020.112078
	10738183	11149	0	None	-41	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	374	5	1	3	4.3	COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	CHEMBL10124	11149	0	None	-41	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	374	5	1	3	4.3	COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	1358	6912	41	None	-870	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm401343c
	3976006	6912	41	None	-870	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm401343c
	CHEMBL285718	6912	41	None	-870	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm401343c
	22718661	23611	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	7	1	3	3.2	CCCc1nc2cccc(CCCNC(=O)CC)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL124783	23611	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	7	1	3	3.2	CCCc1nc2cccc(CCCNC(=O)CC)c2o1	10.1016/j.bmcl.2004.04.082
	168288029	198400	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	471	9	1	9	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5195595	198400	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	471	9	1	9	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	54582194	67531	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	330	6	1	5	2.2	COc1ccc2c(CN3CCCCC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760950	67531	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	330	6	1	5	2.2	COc1ccc2c(CN3CCCCC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	16094582	90089	5	None	-44	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.3	CC(=O)NCC=C(c1ccccc1)c1ccccc1	10.1021/jm060850a
	CHEMBL219076	90089	5	None	-44	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.3	CC(=O)NCC=C(c1ccccc1)c1ccccc1	10.1021/jm060850a
	10666373	105097	0	None	-4	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	5	1	3	4.3	CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	CHEMBL274995	105097	0	None	-4	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	5	1	3	4.3	CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	10737372	11404	0	None	-37	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	5	1	3	4.3	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCCc1ccccc1-2	10.1021/jm980684+
	CHEMBL10293	11404	0	None	-37	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	5	1	3	4.3	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCCc1ccccc1-2	10.1021/jm980684+
	52953165	69182	0	None	-218	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	389	7	1	3	5.6	C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779810	69182	0	None	-218	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	389	7	1	3	5.6	C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	320362	56501	47	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	230	3	0	3	3.1	CC(C)=CCOc1ccc2ccc(=O)oc2c1	10.1021/acs.jnatprod.7b00853
	CHEMBL156692	56501	47	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	230	3	0	3	3.1	CC(C)=CCOc1ccc2ccc(=O)oc2c1	10.1021/acs.jnatprod.7b00853
	10563168	126470	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	258	4	2	2	2.6	COc1cccc2[nH]c(CNC(=O)C3CCC3)cc12	10.1021/jm001125h
	CHEMBL34729	126470	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	258	4	2	2	2.6	COc1cccc2[nH]c(CNC(=O)C3CCC3)cc12	10.1021/jm001125h
	10563168	126470	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	258	4	2	2	2.6	COc1cccc2[nH]c(CNC(=O)C3CCC3)cc12	10.1021/jm970721h
	CHEMBL34729	126470	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	258	4	2	2	2.6	COc1cccc2[nH]c(CNC(=O)C3CCC3)cc12	10.1021/jm970721h
	16094577	90253	4	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	297	7	1	2	3.5	CCC(=O)NCC(Cc1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
	CHEMBL220136	90253	4	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	297	7	1	2	3.5	CCC(=O)NCC(Cc1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
	9818487	180312	0	None	-141	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	319	5	1	2	4.2	COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL453138	180312	0	None	-141	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	319	5	1	2	4.2	COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	9884156	214655	0	None	-77	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	7	1	3	3.9	C=CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL96548	214655	0	None	-77	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	7	1	3	3.9	C=CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	44429457	176130	0	None	-6	2	Human	5.3	pKi	=	5.3	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	350	7	1	3	4.3	CCCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL441916	176130	0	None	-6	2	Human	5.3	pKi	=	5.3	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	350	7	1	3	4.3	CCCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	49865265	22645	2	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1cccc(SCCNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223124	22645	2	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1cccc(SCCNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	162643514	188466	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	271	5	1	4	1.7	COc1ccc2ncnc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4776540	188466	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	271	5	1	4	1.7	COc1ccc2ncnc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2020.112078
	11208632	129683	1	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	294	4	1	2	3.5	CCC(=O)NCCN1c2ccccc2CCc2ccccc21	10.1021/jm040768k
	CHEMBL360600	129683	1	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	294	4	1	2	3.5	CCC(=O)NCCN1c2ccccc2CCc2ccccc21	10.1021/jm040768k
	11277044	133380	1	None	-6	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	263	2	1	1	3.3	CC(=O)NCC1=Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
	CHEMBL365249	133380	1	None	-6	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	263	2	1	1	3.3	CC(=O)NCC1=Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
	16094588	143500	4	None	-208	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	311	8	1	2	4.1	CCCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
	CHEMBL374075	143500	4	None	-208	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	311	8	1	2	4.1	CCCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
	11046748	214716	0	None	-19	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	365	8	1	4	3.9	C=CC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL96916	214716	0	None	-19	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	365	8	1	4	3.9	C=CC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	162673916	189813	0	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	327	6	1	5	2.9	COc1ccc2[nH]cc(CCc3nn(CC4CCC4)c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	CHEMBL4793947	189813	0	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	327	6	1	5	2.9	COc1ccc2[nH]cc(CCc3nn(CC4CCC4)c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	162673578	189897	0	None	-5	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	272	5	2	5	2.4	CNc1nnc(CCc2c[nH]c3ccc(OC)cc23)o1	10.1016/j.ejmech.2020.112090
	CHEMBL4794879	189897	0	None	-5	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	272	5	2	5	2.4	CNc1nnc(CCc2c[nH]c3ccc(OC)cc23)o1	10.1016/j.ejmech.2020.112090
	45268318	203105	0	None	-6	2	Human	5.3	pKi	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	315	4	1	4	2.2	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCN(C)C1	10.1016/j.bmc.2009.04.068
	CHEMBL562328	203105	0	None	-6	2	Human	5.3	pKi	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	315	4	1	4	2.2	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCN(C)C1	10.1016/j.bmc.2009.04.068
	11109646	213851	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	309	5	2	3	3.4	CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(O)cc12	10.1021/jm0005252
	CHEMBL91813	213851	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	309	5	2	3	3.4	CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(O)cc12	10.1021/jm0005252
	122188224	129920	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	248	4	2	3	1.9	CCC(=O)NCC1CCc2c(cccc2OC)N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612455	129920	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	248	4	2	3	1.9	CCC(=O)NCC1CCc2c(cccc2OC)N1	10.1021/acs.jmedchem.5b01066
	53231366	69175	0	None	-66	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	5	1	3	5.0	CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779804	69175	0	None	-66	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	5	1	3	5.0	CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	11393103	132582	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	322	5	1	3	3.8	CCC(=O)NCCN1c2ccccc2C=Cc2ccc(OC)cc21	10.1021/jm040768k
	CHEMBL364806	132582	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	322	5	1	3	3.8	CCC(=O)NCCN1c2ccccc2C=Cc2ccc(OC)cc21	10.1021/jm040768k
	90666304	116158	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	401	7	2	3	4.6	COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1039/C1MD00149C
	CHEMBL3219325	116158	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	401	7	2	3	4.6	COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1039/C1MD00149C
	56678563	71223	0	None	14	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	484	16	2	6	3.5	CC(=O)NCCN(C)c1cccc(OCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813320	71223	0	None	14	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	484	16	2	6	3.5	CC(=O)NCCN(C)c1cccc(OCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	11529521	83534	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	298	5	2	2	3.1	COc1ccc2[nH]cc(C3(CNC(=O)C4CC4)CCC3)c2c1	10.1021/jm0512544
	CHEMBL206790	83534	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	298	5	2	2	3.1	COc1ccc2[nH]cc(C3(CNC(=O)C4CC4)CCC3)c2c1	10.1021/jm0512544
	122178508	128104	0	None	-8	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	243	4	1	4	2.3	COc1ccc2[nH]cc(CCc3nnco3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580917	128104	0	None	-8	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	243	4	1	4	2.3	COc1ccc2[nH]cc(CCc3nnco3)c2c1	10.1021/acs.jmedchem.5b00245
	137633839	163389	0	None	-7	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4068922	163389	0	None	-7	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
	137640743	163824	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1ccc2ccc(CCNC(C)=O)cc2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4073867	163824	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1ccc2ccc(CCNC(C)=O)cc2n1	10.1016/j.ejmech.2016.12.013
	16094586	89923	4	None	-213	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	311	6	1	3	3.3	COc1cccc(C(=CCNC(C)=O)c2cccc(OC)c2)c1	10.1021/jm060850a
	CHEMBL218225	89923	4	None	-213	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	311	6	1	3	3.3	COc1cccc(C(=CCNC(C)=O)c2cccc(OC)c2)c1	10.1021/jm060850a
	145968467	171568	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	400	13	2	5	4.0	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(O)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4218247	171568	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	400	13	2	5	4.0	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(O)c2)c1	10.1021/acs.jmedchem.8b00893
	44429456	94704	0	None	-8	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	336	6	1	3	3.9	CCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL233945	94704	0	None	-8	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	336	6	1	3	3.9	CCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	16743288	99102	0	None	-14	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	338	5	1	2	4.7	CCCC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1	10.1016/j.ejmech.2007.01.005
	CHEMBL243003	99102	0	None	-14	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	338	5	1	2	4.7	CCCC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1	10.1016/j.ejmech.2007.01.005
	11595087	83442	0	None	-6	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	328	6	1	3	3.9	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1	10.1021/jm0512544
	CHEMBL206419	83442	0	None	-6	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	328	6	1	3	3.9	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1	10.1021/jm0512544
	137645887	164719	0	None	-58	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	294	4	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(Cc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4084568	164719	0	None	-58	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	294	4	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(Cc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	1358	6912	41	None	-870	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm800974d
	3976006	6912	41	None	-870	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm800974d
	CHEMBL285718	6912	41	None	-870	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm800974d
	44424020	92137	0	None	-7	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	676	20	4	8	5.8	COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL226171	92137	0	None	-7	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	676	20	4	8	5.8	COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	39847023	91176	1	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	330	9	1	3	4.9	COc1cc(/C=C/C(=O)O)ccc1OC/C=C(\C)CCC=C(C)C	10.1021/acs.jnatprod.7b00853
	CHEMBL221960	91176	1	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	330	9	1	3	4.9	COc1cc(/C=C/C(=O)O)ccc1OC/C=C(\C)CCC=C(C)C	10.1021/acs.jnatprod.7b00853
	20590665	130407	0	None	14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	391	9	1	2	5.3	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL361854	130407	0	None	14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	391	9	1	2	5.3	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	44358312	36595	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	3	1	3	2.0	CC(C)C(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL138744	36595	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	3	1	3	2.0	CC(C)C(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	145986330	173836	0	None	-15	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	286	3	2	2	2.7	COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4289115	173836	0	None	-15	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	286	3	2	2	2.7	COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3	10.1016/j.ejmech.2017.10.025
	18522272	72863	0	None	15	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	375	10	1	2	5.5	O=C(NCCCc1cccc2oc(CCCCc3ccccc3)cc12)C1CC1	10.1016/j.bmcl.2004.07.055
	CHEMBL183846	72863	0	None	15	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	375	10	1	2	5.5	O=C(NCCCc1cccc2oc(CCCCc3ccccc3)cc12)C1CC1	10.1016/j.bmcl.2004.07.055
	145972981	171274	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	513	13	3	4	6.2	CC(=O)NCCc1c[nH]c2ccc(OCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12	10.1021/acs.jmedchem.8b00893
	CHEMBL4214478	171274	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	513	13	3	4	6.2	CC(=O)NCCc1c[nH]c2ccc(OCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12	10.1021/acs.jmedchem.8b00893
	11507534	172912	0	None	-5	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	288	5	1	3	3.0	CCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	CHEMBL426127	172912	0	None	-5	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	288	5	1	3	3.0	CCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	11185529	10686	5	None	-14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm040768k
	7772	10686	5	None	-14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm040768k
	CHEMBL189449	10686	5	None	-14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm040768k
	127041168	143382	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	388	10	2	3	3.9	O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F	10.1039/C5MD00190K
	CHEMBL3739674	143382	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	388	10	2	3	3.9	O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F	10.1039/C5MD00190K
	11185529	10686	5	None	-14	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm048956y
	7772	10686	5	None	-14	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm048956y
	CHEMBL189449	10686	5	None	-14	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm048956y
	127041168	143382	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	388	10	2	3	3.9	O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F	10.1039/C5MD00190K
	CHEMBL3739674	143382	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	388	10	2	3	3.9	O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F	10.1039/C5MD00190K
	10611901	30348	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	267	5	1	1	3.8	CCCC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL133426	30348	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	267	5	1	1	3.8	CCCC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	10801655	28147	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	265	4	1	1	3.4	O=C(NCCC1Cc2cccc3cccc1c23)C1CC1	10.1021/jm000922c
	CHEMBL131431	28147	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	265	4	1	1	3.4	O=C(NCCC1Cc2cccc3cccc1c23)C1CC1	10.1021/jm000922c
	10800029	123488	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	3	1	1	3.0	CC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL337295	123488	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	3	1	1	3.0	CC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	44358275	175232	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	287	3	2	3	1.7	O=C(NC1CC1)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL435023	175232	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	287	3	2	3	1.7	O=C(NC1CC1)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	22718564	23552	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	5	1	3	2.3	CCC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124476	23552	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	5	1	3	2.3	CCC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
	44241665	202479	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	329	6	1	4	2.6	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
	CHEMBL556908	202479	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	329	6	1	4	2.6	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
	44426096	92511	0	None	-4	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	211	2	1	1	2.9	CC(=O)N/C=C/c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
	CHEMBL229015	92511	0	None	-4	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	211	2	1	1	2.9	CC(=O)N/C=C/c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
	10061064	109745	0	None	-7	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	258	5	1	3	2.3	CCC(=O)NCCc1ccnc2ccc(OC)cc12	10.1016/S0960-894X(97)00392-2
	CHEMBL306468	109745	0	None	-7	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	258	5	1	3	2.3	CCC(=O)NCCc1ccnc2ccc(OC)cc12	10.1016/S0960-894X(97)00392-2
	44389768	71317	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	426	9	2	2	5.5	CCNC(=O)NC[C@@H]1C[C@H]1c1c(Cl)ccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL181457	71317	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	426	9	2	2	5.5	CCNC(=O)NC[C@@H]1C[C@H]1c1c(Cl)ccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	22718654	120109	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	7	1	3	3.5	CCCc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL331636	120109	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	7	1	3	3.5	CCCc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
	22718596	124151	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	322	7	1	3	4.3	CCCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL339784	124151	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	322	7	1	3	4.3	CCCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	137655435	165589	0	None	-15	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1cnc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2016.12.013
	CHEMBL4094436	165589	0	None	-15	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1cnc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2016.12.013
	12985495	188165	0	None	-213	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	377	8	2	3	4.5	CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
	CHEMBL476341	188165	0	None	-213	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	377	8	2	3	4.5	CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
	122162	9166	75	None	-18	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm980684+
	1363	9166	75	None	-18	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm980684+
	CHEMBL286615	9166	75	None	-18	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm980684+
	44264706	211209	1	None	-33	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	270	5	2	3	3.8	CCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7215	211209	1	None	-33	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	270	5	2	3	3.8	CCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	44264689	211830	1	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	282	5	2	3	3.8	COc1cccc(Nc2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL7713	211830	1	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	282	5	2	3	3.8	COc1cccc(Nc2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
	90666308	116162	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	389	7	2	3	3.8	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CC3)c2c1	10.1039/C1MD00149C
	CHEMBL3219329	116162	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	389	7	2	3	3.8	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CC3)c2c1	10.1039/C1MD00149C
	44429453	94316	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	322	6	2	2	3.9	CCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL233517	94316	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	322	6	2	2	3.9	CCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	3964826	22626	30	None	-1	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1ccc(OCCNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223054	22626	30	None	-1	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1ccc(OCCNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
	44412063	84363	0	None	2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	298	4	2	3	2.8	Cn1cc(C2(CNC(=O)C3CC3)CCC2)c2cc(O)ccc21	10.1021/jm0512544
	CHEMBL208802	84363	0	None	2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	298	4	2	3	2.8	Cn1cc(C2(CNC(=O)C3CC3)CCC2)c2cc(O)ccc21	10.1021/jm0512544
	137637541	162777	0	None	-269	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	293	4	1	1	3.9	CCC(=O)NC[C@@H]1CCc2ccccc2[C@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
	CHEMBL4061850	162777	0	None	-269	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	293	4	1	1	3.9	CCC(=O)NC[C@@H]1CCc2ccccc2[C@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
	9947753	211679	0	None	-83	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	285	6	1	3	4.2	CCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7599	211679	0	None	-83	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	285	6	1	3	4.2	CCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	44264949	211747	0	None	-83	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	299	7	1	3	4.6	CCCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7650	211747	0	None	-83	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	299	7	1	3	4.6	CCCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	145990308	173811	0	None	-20	3	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	328	5	2	2	3.8	CCCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4288690	173811	0	None	-20	3	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	328	5	2	2	3.8	CCCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	10567865	10950	0	None	-38	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	322	6	1	3	3.7	CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
	CHEMBL100104	10950	0	None	-38	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	322	6	1	3	3.7	CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
	10567865	10950	0	None	-38	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	322	6	1	3	3.7	CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm970721h
	CHEMBL100104	10950	0	None	-38	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	322	6	1	3	3.7	CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm970721h
	10639585	121241	0	None	-83	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm001125h
	CHEMBL33346	121241	0	None	-83	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm001125h
	10513751	170073	1	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1cccc2[nH]c(CCNC(C)=O)cc12	10.1021/jm001125h
	CHEMBL418789	170073	1	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1cccc2[nH]c(CCNC(C)=O)cc12	10.1021/jm001125h
	10639585	121241	0	None	-83	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm970721h
	CHEMBL33346	121241	0	None	-83	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm970721h
	10513751	170073	1	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1cccc2[nH]c(CCNC(C)=O)cc12	10.1021/jm970721h
	CHEMBL418789	170073	1	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1cccc2[nH]c(CCNC(C)=O)cc12	10.1021/jm970721h
	11310062	22700	2	None	-1	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)N[C@H](C)COc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223274	22700	2	None	-1	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)N[C@H](C)COc1ccccc1	10.1016/j.bmc.2010.06.100
	122188345	129939	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	334	5	1	2	3.9	O=C(NCC1CCc2ccccc2N1Cc1ccccc1)C1CCC1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612602	129939	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	334	5	1	2	3.9	O=C(NCC1CCc2ccccc2N1Cc1ccccc1)C1CCC1	10.1021/acs.jmedchem.5b01066
	10969292	214611	0	None	-7	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	321	6	1	2	4.3	CCc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL96333	214611	0	None	-7	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	321	6	1	2	4.3	CCc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	44424025	91949	0	None	1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	504	14	4	4	4.6	COc1ccc2[nH]cc(CCNC(=O)CCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL225302	91949	0	None	1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	504	14	4	4	4.6	COc1ccc2[nH]cc(CCNC(=O)CCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1016/j.bmc.2007.03.080
	11680808	83854	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	5	2	2	3.1	CCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	CHEMBL207420	83854	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	5	2	2	3.1	CCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	1359	8951	21	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm800974d
	5311198	8951	21	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm800974d
	CHEMBL274438	8951	21	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm800974d
	1359	8951	21	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm048956y
	5311198	8951	21	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm048956y
	CHEMBL274438	8951	21	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm048956y
	1359	8951	21	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm980684+
	5311198	8951	21	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm980684+
	CHEMBL274438	8951	21	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm980684+
	1359	8951	21	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm401343c
	5311198	8951	21	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm401343c
	CHEMBL274438	8951	21	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm401343c
	10925526	119111	0	None	-26	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	329	6	1	3	4.2	COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL329299	119111	0	None	-26	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	329	6	1	3	4.2	COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	44357899	125459	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	4	1	3	2.1	CCCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL341705	125459	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	4	1	3	2.1	CCCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	118712372	120929	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	308	2	1	2	3.4	CCNC(=O)N1CCCC2Cc3cc(Cl)c(OC)cc3C21	10.1016/j.ejmech.2014.09.038
	CHEMBL3329390	120929	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	308	2	1	2	3.4	CCNC(=O)N1CCCC2Cc3cc(Cl)c(OC)cc3C21	10.1016/j.ejmech.2014.09.038
	127040355	144691	0	None	-13	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	410	5	1	4	5.5	COc1ccc2oc(-c3cc4ccccc4c4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3763537	144691	0	None	-13	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	410	5	1	4	5.5	COc1ccc2oc(-c3cc4ccccc4c4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	16094580	88333	4	None	-11	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.0	COc1ccc(Cc2ccccc2)c(CCNC(C)=O)c1	10.1021/jm060850a
	CHEMBL216158	88333	4	None	-11	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.0	COc1ccc(Cc2ccccc2)c(CCNC(C)=O)c1	10.1021/jm060850a
	137657824	166576	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4105511	166576	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
	162668486	189353	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	377	8	1	5	3.7	COc1ccc2[nH]cc(CCc3nn(CCCc4ccccc4)c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	CHEMBL4787877	189353	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	377	8	1	5	3.7	COc1ccc2[nH]cc(CCc3nn(CCCc4ccccc4)c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	10893437	215228	0	None	-6	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	348	6	1	3	4.1	COc1cccc2c1cc(CCNC(=O)C1CCC1)n2-c1ccccc1	10.1021/jm001125h
	CHEMBL99987	215228	0	None	-6	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	348	6	1	3	4.1	COc1cccc2c1cc(CCNC(=O)C1CCC1)n2-c1ccccc1	10.1021/jm001125h
	16094591	90098	4	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.2	COc1cccc(C(CNC(C)=O)Cc2ccccc2)c1	10.1021/jm060850a
	CHEMBL219127	90098	4	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.2	COc1cccc(C(CNC(C)=O)Cc2ccccc2)c1	10.1021/jm060850a
	10948786	214579	0	None	-18	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	375	7	1	4	4.6	COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)c3ccco3)c2c1	10.1021/jm0005252
	CHEMBL96173	214579	0	None	-18	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	375	7	1	4	4.6	COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)c3ccco3)c2c1	10.1021/jm0005252
	44358231	33721	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	275	3	2	3	1.5	CCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL136431	33721	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	275	3	2	3	1.5	CCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	145979585	173269	0	None	-17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	313	5	2	3	3.0	CCCNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4278446	173269	0	None	-17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	313	5	2	3	3.0	CCCNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	145991111	173691	0	None	-17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	319	5	1	3	2.8	CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4286494	173691	0	None	-17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	319	5	1	3	2.8	CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137645530	164502	0	None	-23	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	260	4	1	4	2.1	COC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4082097	164502	0	None	-23	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	260	4	1	4	2.1	COC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	11002840	214306	0	None	-33	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	357	6	1	3	4.4	COc1ccc2oc(Cc3cccc(Cl)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL94607	214306	0	None	-33	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	357	6	1	3	4.4	COc1ccc2oc(Cc3cccc(Cl)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	10616723	105081	0	None	-14	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	4	1	3	3.6	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCc2ccccc2-1	10.1021/jm980684+
	CHEMBL274842	105081	0	None	-14	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	4	1	3	3.6	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCc2ccccc2-1	10.1021/jm980684+
	44436051	158142	6	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	209	5	1	3	1.2	COc1cccc(OCCNC(C)=O)c1	10.1021/jm700957j
	CHEMBL396132	158142	6	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	209	5	1	3	1.2	COc1cccc(OCCNC(C)=O)c1	10.1021/jm700957j
	10384120	131169	0	None	7	2	Human	8.1	pKi	=	8.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	363	10	1	2	5.5	CCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL363936	131169	0	None	7	2	Human	8.1	pKi	=	8.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	363	10	1	2	5.5	CCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	44317725	212450	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	329	9	1	3	4.1	CCCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
	CHEMBL82135	212450	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	329	9	1	3	4.1	CCCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
	11644612	85073	0	None	-9	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
	CHEMBL210791	85073	0	None	-9	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
	168288029	198400	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	471	9	1	9	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5195595	198400	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	471	9	1	9	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	49865269	22650	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(O[C@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223129	22650	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(O[C@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	56653479	117647	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3260986	117647	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	56653479	117647	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1021/jm401343c
	CHEMBL3260986	117647	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1021/jm401343c
	16750566	148810	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	662	19	4	8	5.4	COc1ccc2[nH]c(C(=O)OCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL387655	148810	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	662	19	4	8	5.4	COc1ccc2[nH]c(C(=O)OCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	56653479	117647	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3260986	117647	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	44424023	151592	0	None	-14	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	346	9	2	4	3.2	CCCCCOC(=O)c1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2007.03.080
	CHEMBL390944	151592	0	None	-14	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	346	9	2	4	3.2	CCCCCOC(=O)c1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2007.03.080
	49865323	22672	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NC[C@@H](C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223197	22672	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NC[C@@H](C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	10711649	214563	0	None	-19	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	332	5	1	2	4.3	CCCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
	CHEMBL9605	214563	0	None	-19	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	332	5	1	2	4.3	CCCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
	16094576	144910	6	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	253	5	1	1	3.1	CC(=O)NCC(Cc1ccccc1)c1ccccc1	10.1021/jm060850a
	CHEMBL376693	144910	6	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	253	5	1	1	3.1	CC(=O)NCC(Cc1ccccc1)c1ccccc1	10.1021/jm060850a
	81689735	128103	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	257	4	1	4	2.7	COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580916	128103	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	257	4	1	4	2.7	COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3109560	217867	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 mins	ChEMBL		None	None	None		COc1ccc(/C=C/C2=[N+]3C(=Cc4c(CCNC(C)=O)c5cc(OC)ccc5n4[B-]3(F)F)C=C2)cc1	10.1021/ml4004155
	681	8247	72	None	-38	38	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
	940	8247	72	None	-38	38	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
	947	8247	72	None	-38	38	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
	CHEMBL59	8247	72	None	-38	38	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
	DB00988	8247	72	None	-38	38	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
	11624018	147666	0	None	5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	326	5	1	3	3.5	COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCC1)cn2C	10.1021/jm0512544
	CHEMBL382050	147666	0	None	5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	326	5	1	3	3.5	COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCC1)cn2C	10.1021/jm0512544
	44412082	146057	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	5	2	3	3.2	CCCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
	CHEMBL379096	146057	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	5	2	3	3.2	CCCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
	127025781	144602	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3oc(CCNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759859	144602	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3oc(CCNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	127039218	144674	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	234	4	1	4	1.5	COc1cc2c(CCNC(C)=O)coc2cn1	10.1016/j.ejmech.2016.01.008
	CHEMBL3763247	144674	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	234	4	1	4	1.5	COc1cc2c(CCNC(C)=O)coc2cn1	10.1016/j.ejmech.2016.01.008
	56671858	71228	0	None	-20	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	498	17	2	6	3.8	COc1cccc(N(CCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813325	71228	0	None	-20	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	498	17	2	6	3.8	COc1cccc(N(CCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1	10.1016/j.bmc.2011.06.063
	49865424	22731	0	None	-1	2	Human	4.1	pKi	=	4.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)N[C@H](C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223346	22731	0	None	-1	2	Human	4.1	pKi	=	4.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)N[C@H](C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
	44349171	23427	1	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	275	6	2	3	2.6	CCNC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124217	23427	1	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	275	6	2	3	2.6	CCNC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
	16743123	99851	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	270	5	1	2	3.0	CCC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
	CHEMBL244263	99851	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	270	5	1	2	3.0	CCC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
	11794657	215100	0	None	-23	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	388	5	1	3	4.7	COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	CHEMBL9917	215100	0	None	-23	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	388	5	1	3	4.7	COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	10567427	11012	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	316	4	1	2	3.7	O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CC1	10.1021/jm980684+
	CHEMBL10043	11012	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	316	4	1	2	3.7	O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CC1	10.1021/jm980684+
	24749950	10688	8	None	-588	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C	10.1021/jm700957j
	7923	10688	8	None	-588	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C	10.1021/jm700957j
	CHEMBL394676	10688	8	None	-588	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C	10.1021/jm700957j
	9859693	80900	1	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	246	6	0	3	3.3	COc1cc(/C=C/C=O)ccc1OCC=C(C)C	10.1021/acs.jnatprod.7b00853
	CHEMBL2022666	80900	1	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	246	6	0	3	3.3	COc1cc(/C=C/C=O)ccc1OCC=C(C)C	10.1021/acs.jnatprod.7b00853
	10807560	214926	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	346	5	1	2	4.7	CCCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
	CHEMBL9815	214926	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	346	5	1	2	4.7	CCCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
	122162	9166	75	None	-18	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1016/j.ejmech.2007.01.005
	1363	9166	75	None	-18	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1016/j.ejmech.2007.01.005
	CHEMBL286615	9166	75	None	-18	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1016/j.ejmech.2007.01.005
	10044270	196323	0	None	-891	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	1	2	4.8	COc1ccc2c(c1)[C@@H](CCNC(=O)C1CCC1)C[C@@H](c1ccccc1)C2	10.1021/jm800974d
	CHEMBL514280	196323	0	None	-891	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	1	2	4.8	COc1ccc2c(c1)[C@@H](CCNC(=O)C1CCC1)C[C@@H](c1ccccc1)C2	10.1021/jm800974d
	45270052	202172	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	381	8	2	4	3.5	COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1016/j.bmc.2009.04.068
	CHEMBL552002	202172	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	381	8	2	4	3.5	COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1016/j.bmc.2009.04.068
	137650611	164291	0	None	-26	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	CNC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4079784	164291	0	None	-26	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	CNC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	9970584	23543	0	None	-8	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	7	1	3	3.2	CCCC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124422	23543	0	None	-8	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	7	1	3	3.2	CCCC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
	44317822	111653	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	315	8	1	3	3.7	CCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
	CHEMBL311106	111653	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	315	8	1	3	3.7	CCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
	45270052	202172	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	381	8	2	4	3.5	COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1016/j.bmc.2009.04.068
	CHEMBL552002	202172	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	381	8	2	4	3.5	COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1016/j.bmc.2009.04.068
	10938056	113835	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	393	11	1	3	5.7	CCCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL315653	113835	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	393	11	1	3	5.7	CCCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	11637615	84022	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	272	4	2	2	2.7	COc1ccc2[nH]cc(C3(CNC(C)=O)CCC3)c2c1	10.1021/jm0512544
	CHEMBL207960	84022	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	272	4	2	2	2.7	COc1ccc2[nH]cc(C3(CNC(C)=O)CCC3)c2c1	10.1021/jm0512544
	11681026	83915	0	None	-11	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	302	6	1	3	3.4	CCCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	CHEMBL207745	83915	0	None	-11	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	302	6	1	3	3.4	CCCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	49865270	22652	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(SC(C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223131	22652	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(SC(C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	11733059	118431	0	None	-21	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	449	7	1	3	4.1	COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)CI)c2c1	10.1021/jm0005252
	CHEMBL328617	118431	0	None	-21	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	449	7	1	3	4.1	COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)CI)c2c1	10.1021/jm0005252
	44429444	153509	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.2	COc1cc(C)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
	CHEMBL392421	153509	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.2	COc1cc(C)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
	9860588	26718	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	COc1ccc2cccc3c2c1CCC3CCNC(C)=O	10.1021/jm000922c
	CHEMBL130286	26718	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	COc1ccc2cccc3c2c1CCC3CCNC(C)=O	10.1021/jm000922c
	10522674	214540	0	None	-56	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	7	1	3	4.5	CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)Cc1ccccc1-2	10.1021/jm980684+
	CHEMBL9590	214540	0	None	-56	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	7	1	3	4.5	CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)Cc1ccccc1-2	10.1021/jm980684+
	11784134	113726	0	None	-67	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	391	6	1	3	4.7	COc1ccc2oc(Cc3cccc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL314947	113726	0	None	-67	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	391	6	1	3	4.7	COc1ccc2oc(Cc3cccc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	49865320	22669	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NC[C@@H](C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223194	22669	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NC[C@@H](C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	1354	10209	15	None	-275	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	10.1016/j.bmc.2008.08.052
	22133318	10209	15	None	-275	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	10.1016/j.bmc.2008.08.052
	CHEMBL490188	10209	15	None	-275	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	10.1016/j.bmc.2008.08.052
	44579115	188614	0	None	-162	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	348	6	2	3	4.2	CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	CHEMBL477835	188614	0	None	-162	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	348	6	2	3	4.2	CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	54583162	67535	0	None	-7	2	Human	5.1	pKi	=	5.1	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	276	6	2	5	0.9	CNCc1cn(CCNC(C)=O)c2nc(OC)ccc12	10.1016/j.bmcl.2011.02.097
	CHEMBL1760954	67535	0	None	-7	2	Human	5.1	pKi	=	5.1	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	276	6	2	5	0.9	CNCc1cn(CCNC(C)=O)c2nc(OC)ccc12	10.1016/j.bmcl.2011.02.097
	137653199	165402	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	218	2	1	2	1.4	CC(=O)NCC1Cc2ccccc2N(C)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4092308	165402	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	218	2	1	2	1.4	CC(=O)NCC1Cc2ccccc2N(C)C1	10.1021/acs.jmedchem.8b00359
	44424024	91948	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	522	16	2	6	5.6	COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL225301	91948	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	522	16	2	6	5.6	COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	10640625	215075	0	None	-46	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	336	7	1	3	3.8	CCC(=O)NCCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm001125h
	CHEMBL99002	215075	0	None	-46	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	336	7	1	3	3.8	CCC(=O)NCCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm001125h
	10640625	215075	0	None	-46	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	336	7	1	3	3.8	CCC(=O)NCCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm970721h
	CHEMBL99002	215075	0	None	-46	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	336	7	1	3	3.8	CCC(=O)NCCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm970721h
	44264707	103946	1	None	-19	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	256	4	2	3	3.4	COc1cccc(Nc2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL268165	103946	1	None	-19	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	256	4	2	3	3.4	COc1cccc(Nc2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
	9859913	212309	0	None	-20	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	257	4	1	3	3.4	COc1cccc(Oc2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL8094	212309	0	None	-20	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	257	4	1	3	3.4	COc1cccc(Oc2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
	9930390	214659	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	391	6	1	3	5.0	COc1ccc2oc(Cc3c(Cl)cccc3Cl)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL96562	214659	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	391	6	1	3	5.0	COc1ccc2oc(Cc3c(Cl)cccc3Cl)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	25209999	182297	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	441	6	2	3	4.2	COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL457807	182297	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	441	6	2	3	4.2	COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	25209999	182297	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	441	6	2	3	4.2	COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL457807	182297	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	441	6	2	3	4.2	COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	10104923	108277	2	None	-12	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	221	6	1	2	2.2	CCC(=O)NCCCc1cccc(OC)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL297947	108277	2	None	-12	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	221	6	1	2	2.2	CCC(=O)NCCCc1cccc(OC)c1	10.1016/j.bmcl.2010.02.084
	10609620	215088	1	None	-5	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2cc(CCNC(C)=O)[nH]c2c1	10.1021/jm001125h
	CHEMBL99091	215088	1	None	-5	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2cc(CCNC(C)=O)[nH]c2c1	10.1021/jm001125h
	10609620	215088	1	None	-5	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2cc(CCNC(C)=O)[nH]c2c1	10.1021/jm970721h
	CHEMBL99091	215088	1	None	-5	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2cc(CCNC(C)=O)[nH]c2c1	10.1021/jm970721h
	10946222	201520	0	None	-43	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	291	5	1	5	1.8	COc1ccc2c(c(CCNC(C)=O)cn2C)c1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL53622	201520	0	None	-43	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	291	5	1	5	1.8	COc1ccc2c(c(CCNC(C)=O)cn2C)c1[N+](=O)[O-]	10.1021/jm011053+
	11623375	145470	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	5	1	3	2.7	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1	10.1021/jm0512544
	CHEMBL377871	145470	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	5	1	3	2.7	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1	10.1021/jm0512544
	22718548	23273	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	322	6	1	3	4.2	CC(C)C(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL123612	23273	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	322	6	1	3	4.2	CC(C)C(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	71540390	93193	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	235	4	1	3	1.7	COc1ccc(OC)c([C@@H]2C[C@H]2NC(C)=O)c1	10.1016/j.bmcl.2012.11.069
	CHEMBL2314263	93193	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	235	4	1	3	1.7	COc1ccc(OC)c([C@@H]2C[C@H]2NC(C)=O)c1	10.1016/j.bmcl.2012.11.069
	10518884	119331	0	None	-11	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	308	5	1	3	3.3	COc1cccc2c1cc(CCNC(C)=O)n2-c1ccccc1	10.1021/jm001125h
	CHEMBL329979	119331	0	None	-11	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	308	5	1	3	3.3	COc1cccc2c1cc(CCNC(C)=O)n2-c1ccccc1	10.1021/jm001125h
	10518884	119331	0	None	-11	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	308	5	1	3	3.3	COc1cccc2c1cc(CCNC(C)=O)n2-c1ccccc1	10.1021/jm970721h
	CHEMBL329979	119331	0	None	-11	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	308	5	1	3	3.3	COc1cccc2c1cc(CCNC(C)=O)n2-c1ccccc1	10.1021/jm970721h
	46885226	14844	0	None	-18620	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	313	8	1	3	3.3	COc1ccc(OCc2ccccc2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1091160	14844	0	None	-18620	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	313	8	1	3	3.3	COc1ccc(OCc2ccccc2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	76319554	92258	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	228	2	0	3	2.6	CCC#CCOc1ccc2ccc(=O)oc2c1	10.1021/acs.jnatprod.7b00853
	CHEMBL2268532	92258	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	228	2	0	3	2.6	CCC#CCOc1ccc2ccc(=O)oc2c1	10.1021/acs.jnatprod.7b00853
	137656978	166542	0	None	-147	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	294	4	1	2	3.1	CCC(=O)NC1Cc2ccccc2N(Cc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4105125	166542	0	None	-147	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	294	4	1	2	3.1	CCC(=O)NC1Cc2ccccc2N(Cc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	162644724	186173	0	None	-57	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	321	5	1	4	3.0	COc1ccc2nc(-c3ccccc3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4739898	186173	0	None	-57	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	321	5	1	4	3.0	COc1ccc2nc(-c3ccccc3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	46884554	15070	0	None	-128	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	313	8	1	3	3.3	COc1cc(CCCNC(C)=O)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
	CHEMBL1092647	15070	0	None	-128	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	313	8	1	3	3.3	COc1cc(CCCNC(C)=O)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
	44389864	71110	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	380	10	2	2	4.7	CCNC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL181192	71110	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	380	10	2	2	4.7	CCNC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	11165283	129910	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	392	9	2	2	4.8	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL361206	129910	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	392	9	2	2	4.8	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	22718561	24027	0	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	5	1	3	2.5	CCc1nc2cccc(CCCNC(C)=O)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL125665	24027	0	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	5	1	3	2.5	CCc1nc2cccc(CCCNC(C)=O)c2o1	10.1016/j.bmcl.2004.04.082
	52918080	67538	0	None	-13	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	287	4	1	4	2.1	COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3	10.1016/j.bmcl.2011.02.097
	CHEMBL1760957	67538	0	None	-13	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	287	4	1	4	2.1	COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3	10.1016/j.bmcl.2011.02.097
	127038130	143401	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	347	8	1	2	4.5	CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3739824	143401	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	347	8	1	2	4.5	CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12	10.1039/C5MD00190K
	127038132	143592	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	361	9	1	2	4.9	CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3741561	143592	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	361	9	1	2	4.9	CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12	10.1039/C5MD00190K
	145992795	173570	0	None	-29	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	342	5	2	2	3.9	CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4284223	173570	0	None	-29	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	342	5	2	2	3.9	CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	18007928	15437	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	485	12	2	4	5.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CC(=O)O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095504	15437	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	485	12	2	4	5.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CC(=O)O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	49865322	22671	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NCC(C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223196	22671	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NCC(C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	53238181	7721	0	None	-741	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	7780	7721	0	None	-741	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	CHEMBL1774519	7721	0	None	-741	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	59145848	192846	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	3	1	3	2.5	CC(=O)NCCC1CCc2ccn3nc(C)c(C)c3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4871181	192846	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	3	1	3	2.5	CC(=O)NCCC1CCc2ccn3nc(C)c(C)c3c21	10.1021/acs.jmedchem.0c01836
	127038132	143592	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	361	9	1	2	4.9	CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3741561	143592	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	361	9	1	2	4.9	CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12	10.1039/C5MD00190K
	44424017	92098	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	592	14	4	8	3.4	COc1ccc2[nH]c(C(=O)OCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL226112	92098	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	592	14	4	8	3.4	COc1ccc2[nH]c(C(=O)OCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	21581653	144821	0	None	3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.3	COc1cc2c(CCNC(C)=O)c[nH]c2cn1	10.1016/j.ejmech.2016.01.008
	CHEMBL3765249	144821	0	None	3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.3	COc1cc2c(CCNC(C)=O)c[nH]c2cn1	10.1016/j.ejmech.2016.01.008
	25022429	194928	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	393	7	3	4	2.8	COc1ccc2[nH]c(CN3c4ccccc4C[C@H]3CO)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.07.012
	CHEMBL498493	194928	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	393	7	3	4	2.8	COc1ccc2[nH]c(CN3c4ccccc4C[C@H]3CO)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.07.012
	44349108	23636	0	None	-2	2	Human	8.0	pKi	=	8	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	6	1	3	2.7	CCCC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124914	23636	0	None	-2	2	Human	8.0	pKi	=	8	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	6	1	3	2.7	CCCC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
	127025783	144516	0	None	-4	2	Human	8.0	pKi	=	8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759160	144516	0	None	-4	2	Human	8.0	pKi	=	8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1	10.1016/j.ejmech.2015.12.047
	137633385	163192	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human melatonin MT1 assessed as inhibition constantBinding affinity to human melatonin MT1 assessed as inhibition constant	ChEMBL	311	4	0	1	4.8	O=C(c1ccc(F)cc1)N(Cc1ccccc1)C1CCCCC1	10.1021/acs.jmedchem.1c01571
	CHEMBL4066660	163192	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human melatonin MT1 assessed as inhibition constantBinding affinity to human melatonin MT1 assessed as inhibition constant	ChEMBL	311	4	0	1	4.8	O=C(c1ccc(F)cc1)N(Cc1ccccc1)C1CCCCC1	10.1021/acs.jmedchem.1c01571
	CHEMBL5200484	163192	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human melatonin MT1 assessed as inhibition constantBinding affinity to human melatonin MT1 assessed as inhibition constant	ChEMBL	311	4	0	1	4.8	O=C(c1ccc(F)cc1)N(Cc1ccccc1)C1CCCCC1	10.1021/acs.jmedchem.1c01571
	1348	8626	5	None	-100	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10.1021/jm401343c
	44208891	8626	5	None	-100	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10.1021/jm401343c
	CHEMBL3260983	8626	5	None	-100	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10.1021/jm401343c
	54582195	67536	0	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	329	5	1	5	1.9	COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760955	67536	0	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	329	5	1	5	1.9	COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	16094583	172919	3	None	-69	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	291	5	1	1	4.0	O=C(NCC=C(c1ccccc1)c1ccccc1)C1CCC1	10.1021/jm060850a
	CHEMBL426168	172919	3	None	-69	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	291	5	1	1	4.0	O=C(NCC=C(c1ccccc1)c1ccccc1)C1CCC1	10.1021/jm060850a
	11418246	69177	0	None	-4	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	6	1	3	5.8	O=C(NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12)C1CCC1	10.1016/j.ejmech.2011.02.044
	CHEMBL1779806	69177	0	None	-4	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	6	1	3	5.8	O=C(NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12)C1CCC1	10.1016/j.ejmech.2011.02.044
	44264909	212013	0	None	-117	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	293	5	1	2	4.8	CCCC(=O)Nc1ccc(Cc2cccc3occc23)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7875	212013	0	None	-117	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	293	5	1	2	4.8	CCCC(=O)Nc1ccc(Cc2cccc3occc23)cc1	10.1016/j.bmcl.2003.11.030
	44264942	212223	0	None	-19	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	313	5	1	4	4.0	CCCC(=O)Nc1ccc(Oc2cccc3c2OCCO3)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL8032	212223	0	None	-19	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	313	5	1	4	4.0	CCCC(=O)Nc1ccc(Oc2cccc3c2OCCO3)cc1	10.1016/j.bmcl.2003.11.030
	10390684	18102	0	None	-4	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	359	9	1	3	3.0	CCC(=O)NCCc1c(OCC[N+](C)(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL1179488	18102	0	None	-4	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	359	9	1	3	3.0	CCC(=O)NCCc1c(OCC[N+](C)(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL78338	18102	0	None	-4	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	359	9	1	3	3.0	CCC(=O)NCCc1c(OCC[N+](C)(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	16094585	89665	0	None	-204	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	321	6	1	2	4.0	COc1cccc(/C(=C/CNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm060850a
	CHEMBL218065	89665	0	None	-204	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	321	6	1	2	4.0	COc1cccc(/C(=C/CNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm060850a
	54583161	67534	0	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	452	8	1	6	3.4	COc1ccc2c(CN3CCC(C(=O)c4ccc(F)cc4)CC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760953	67534	0	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	452	8	1	6	3.4	COc1ccc2c(CN3CCC(C(=O)c4ccc(F)cc4)CC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	44429454	155994	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	336	7	2	2	4.3	CCCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL394408	155994	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	336	7	2	2	4.3	CCCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	44264962	211629	0	None	-46	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	283	5	1	3	4.0	C/C=C/C(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7559	211629	0	None	-46	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	283	5	1	3	4.0	C/C=C/C(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	18702059	211776	4	None	-7	2	Human	7.0	pKi	=	7	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	283	5	1	3	3.8	COc1cccc(Oc2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL7673	211776	4	None	-7	2	Human	7.0	pKi	=	7	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	283	5	1	3	3.8	COc1cccc(Oc2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
	145979282	173454	0	None	-16	3	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4281915	173454	0	None	-16	3	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	1357	9263	139	None	-1	9	Human	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
	1672	9263	139	None	-1	9	Human	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
	224	9263	139	None	-1	9	Human	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
	896	9263	139	None	-1	9	Human	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
	CHEMBL45	9263	139	None	-1	9	Human	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
	DB01065	9263	139	None	-1	9	Human	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	10.7	pKi	=	10.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	10.7	pKi	=	10.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	10.7	pKi	=	10.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	10.7	pKi	=	10.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	10.7	pKi	=	10.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	10.7	pKi	=	10.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	198	7101	126	125I-Iodomelatonin	-1	6	Human	10.4	pKi	=	10.4	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	82148	7101	126	125I-Iodomelatonin	-1	6	Human	10.4	pKi	=	10.4	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	99	7101	126	125I-Iodomelatonin	-1	6	Human	10.4	pKi	=	10.4	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	CHEMBL10878	7101	126	125I-Iodomelatonin	-1	6	Human	10.4	pKi	=	10.4	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	DB06594	7101	126	125I-Iodomelatonin	-1	6	Human	10.4	pKi	=	10.4	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	9263	139	125I-Mel	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Mel	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Mel	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Mel	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Mel	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Mel	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1349	8630	0	125I-Iodomelatonin	-1	2	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	None
	5311134	8630	0	125I-Iodomelatonin	-1	2	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	None
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	9263	139	125I-Mel	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Mel	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Mel	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Mel	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Mel	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Mel	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	4004	21193	57	35S-GTPGammaS	-	1	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	330	9	0	8	2.1	CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC	None
	CHEMBL1200468	21193	57	35S-GTPGammaS	-	1	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	330	9	0	8	2.1	CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC	None
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	198	7101	126	125I-Mel	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	82148	7101	126	125I-Mel	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	99	7101	126	125I-Mel	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	CHEMBL10878	7101	126	125I-Mel	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	DB06594	7101	126	125I-Mel	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	198	7101	126	125I-Iodomelatonin	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	82148	7101	126	125I-Iodomelatonin	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	99	7101	126	125I-Iodomelatonin	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	CHEMBL10878	7101	126	125I-Iodomelatonin	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	DB06594	7101	126	125I-Iodomelatonin	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	9263	139	125I-Mel	-1	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Mel	-1	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Mel	-1	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Mel	-1	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Mel	-1	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Mel	-1	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	198	7101	126	None	-1	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	82148	7101	126	None	-1	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	99	7101	126	None	-1	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	CHEMBL10878	7101	126	None	-1	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	DB06594	7101	126	None	-1	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	1356	10061	99	None	3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
	208902	10061	99	None	3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
	2355	10061	99	None	3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
	CHEMBL1218	10061	99	None	3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
	DB00980	10061	99	None	3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
	5	6927	72	125I-Mel	-23442	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	6927	72	125I-Mel	-23442	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	6927	72	125I-Mel	-23442	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	6927	72	125I-Mel	-23442	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	107	6929	121	125I-Iodomelatonin	-14791	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	6929	121	125I-Iodomelatonin	-14791	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	6929	121	125I-Iodomelatonin	-14791	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	4209	9937	75	125I-Mel	-26915	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	4893	9937	75	125I-Mel	-26915	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	503	9937	75	125I-Mel	-26915	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	5385	9937	75	125I-Mel	-26915	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	CHEMBL2	9937	75	125I-Mel	-26915	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	DB00457	9937	75	125I-Mel	-26915	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	122162	9166	75	125I-Iodomelatonin	-18	2	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	1363	9166	75	125I-Iodomelatonin	-18	2	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	CHEMBL286615	9166	75	125I-Iodomelatonin	-18	2	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	70547	120120	79	125I-Iodomelatonin	-10	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	202	3	2	1	1.8	CC(=O)NCCc1c[nH]c2ccccc12	None
	CHEMBL33171	120120	79	125I-Iodomelatonin	-10	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	202	3	2	1	1.8	CC(=O)NCCc1c[nH]c2ccccc12	None
	1349	8630	0	125I-Iodomelatonin	-1	2	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	None
	5311134	8630	0	125I-Iodomelatonin	-1	2	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	None
	164157684	222881	0	125I-Iodomelatonin	-60	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	1094	24	4	18	8.7	CC(C)(C)OC(=O)N(C)CC(CN(C)C(=O)OC(C)(C)C)CSP(=O)(O)O.CNCC(CNC)CSP(=O)(OCOC(=O)C1=CC=CC=C1)OCOC(=O)C2=CC=CC=C2.C1=CC=C(C=C1)C(=O)OCCl	None
	903	119678	89	125I-Iodomelatonin	1	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	218	3	3	2	1.6	CC(=O)NCCc1c[nH]c2ccc(O)cc12	None
	CHEMBL33103	119678	89	125I-Iodomelatonin	1	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	218	3	3	2	1.6	CC(=O)NCCc1c[nH]c2ccc(O)cc12	None
	122162	9166	75	125I-Iodomelatonin	-18	2	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	1363	9166	75	125I-Iodomelatonin	-18	2	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	CHEMBL286615	9166	75	125I-Iodomelatonin	-18	2	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	9263	139	125I-Iodomelatonin	-1	9	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Iodomelatonin	-1	9	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Iodomelatonin	-1	9	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Iodomelatonin	-1	9	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Iodomelatonin	-1	9	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Iodomelatonin	-1	9	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1358	6912	41	125I-Iodomelatonin	-870	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	None
	3976006	6912	41	125I-Iodomelatonin	-870	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	None
	CHEMBL285718	6912	41	125I-Iodomelatonin	-870	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	None
	None	222878	0	125I-Iodomelatonin	-1	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	218	2	2	4	1.5	CC(=O)N1C=C(C2=C1C=CC(=C2)O)CCN	None
	None	222878	0	35S-GTPGammaS	-1	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	218	2	2	4	1.5	CC(=O)N1C=C(C2=C1C=CC(=C2)O)CCN	None
	681	8247	72	None	-38	38	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	8247	72	None	-38	38	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	8247	72	None	-38	38	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	8247	72	None	-38	38	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	8247	72	None	-38	38	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	12835	222882	0	125I-Iodomelatonin	-6	2	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	191	3	2	2	1.7	COC1=CC2=C(C=C1)NC=C2CCO	None
	122162	9166	75	125I-Iodomelatonin	-18	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	1363	9166	75	125I-Iodomelatonin	-18	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	CHEMBL286615	9166	75	125I-Iodomelatonin	-18	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	1357	9263	139	125I-Mel	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	9263	139	125I-Mel	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	9263	139	125I-Mel	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	9263	139	125I-Mel	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	9263	139	125I-Mel	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	9263	139	125I-Mel	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	903	119678	89	125I-Iodomelatonin	1	2	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	218	3	3	2	1.6	CC(=O)NCCc1c[nH]c2ccc(O)cc12	None
	CHEMBL33103	119678	89	125I-Iodomelatonin	1	2	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	218	3	3	2	1.6	CC(=O)NCCc1c[nH]c2ccc(O)cc12	None
	70547	120120	79	125I-Iodomelatonin	-10	2	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	202	3	2	1	1.8	CC(=O)NCCc1c[nH]c2ccccc12	None
	CHEMBL33171	120120	79	125I-Iodomelatonin	-10	2	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	202	3	2	1	1.8	CC(=O)NCCc1c[nH]c2ccccc12	None
	10220503	10528	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
	4820	10528	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
	7393	10528	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
	CHEMBL2103822	10528	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
	DB09071	10528	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
	None	222878	0	125I-Mel	-1	2	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	218	2	2	4	1.5	CC(=O)N1C=C(C2=C1C=CC(=C2)O)CCN	None
	198	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
	198	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
	82148	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
	82148	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
	99	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
	99	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
	CHEMBL10878	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
	CHEMBL10878	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
	DB06594	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
	DB06594	7101	126	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
	24954989	8314	1	None	6	2	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	21568291
	7774	8314	1	None	6	2	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	21568291
	CHEMBL1802025	8314	1	None	6	2	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	21568291
	71533431	6866	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	23265885
	7775	6866	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	23265885
	CHEMBL2314259	6866	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	23265885
	57381112	8198	0	None	20	2	Human	10.5	pKi	=	10.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	22301214
	7776	8198	0	None	20	2	Human	10.5	pKi	=	10.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	22301214
	CHEMBL1946221	8198	0	None	20	2	Human	10.5	pKi	=	10.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	22301214
	115348	6858	47	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	12764576
	115348	6858	47	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	2991499
	1343	6858	47	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	12764576
	1343	6858	47	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	2991499
	CHEMBL289233	6858	47	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	12764576
	CHEMBL289233	6858	47	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	2991499
	DB08190	6858	47	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	12764576
	DB08190	6858	47	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	2991499
	1356	10061	99	None	3	2	Human	10.9	pKi	=	10.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
	208902	10061	99	None	3	2	Human	10.9	pKi	=	10.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
	2355	10061	99	None	3	2	Human	10.9	pKi	=	10.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
	CHEMBL1218	10061	99	None	3	2	Human	10.9	pKi	=	10.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
	DB00980	10061	99	None	3	2	Human	10.9	pKi	=	10.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
	11196	8767	0	None	-3	2	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	888	18	3	11	5.9	COc1ccc2c(n1)c(CCNC(=O)C)cn2CCNC(=O)CCCCCN1c2ccc(cc2C(/C/1=C\C=C\C1=[N+](CC)c2c(C1(C)C)cc(cc2)S(=O)(=O)O)(C)C)S(=O)(=O)[O-]	28493341
	154699456	8767	0	None	-3	2	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	888	18	3	11	5.9	COc1ccc2c(n1)c(CCNC(=O)C)cn2CCNC(=O)CCCCCN1c2ccc(cc2C(/C/1=C\C=C\C1=[N+](CC)c2c(C1(C)C)cc(cc2)S(=O)(=O)O)(C)C)S(=O)(=O)[O-]	28493341
	122162	9166	75	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10696085
	122162	9166	75	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	12764576
	122162	9166	75	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	2843633
	122162	9166	75	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	9089668
	1363	9166	75	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10696085
	1363	9166	75	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	12764576
	1363	9166	75	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	2843633
	1363	9166	75	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	9089668
	CHEMBL286615	9166	75	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10696085
	CHEMBL286615	9166	75	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	12764576
	CHEMBL286615	9166	75	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	2843633
	CHEMBL286615	9166	75	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	9089668
	7773	10687	0	None	-12	2	Human	6.9	pKi	=	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	296	3	2	2	2.6	COc1ccc2c(c1)C(CNC(=O)N)Cc1c(C2)cccc1	17907131
	86277838	10687	0	None	-12	2	Human	6.9	pKi	=	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	296	3	2	2	2.6	COc1ccc2c(c1)C(CNC(=O)N)Cc1c(C2)cccc1	17907131
	11185529	10686	5	None	-14	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	15293992
	11185529	10686	5	None	-14	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	17907131
	7772	10686	5	None	-14	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	15293992
	7772	10686	5	None	-14	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	17907131
	CHEMBL189449	10686	5	None	-14	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	15293992
	CHEMBL189449	10686	5	None	-14	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	17907131
	1346	6948	47	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	12764576
	1346	6948	47	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	2991499
	1346	6948	47	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9089668
	1346	6948	47	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9618428
	1858	6948	47	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	12764576
	1858	6948	47	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	2991499
	1858	6948	47	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9089668
	1858	6948	47	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9618428
	CHEMBL34730	6948	47	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	12764576
	CHEMBL34730	6948	47	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	2991499
	CHEMBL34730	6948	47	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9089668
	CHEMBL34730	6948	47	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9618428
	24763223	7004	0	None	74	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	22927210
	8289	7004	0	None	74	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	22927210
	CHEMBL3260987	7004	0	None	74	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	22927210
	1347	6950	56	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10696085
	1347	6950	56	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	2991499
	1347	6950	56	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9089668
	1347	6950	56	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9618428
	1864	6950	56	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10696085
	1864	6950	56	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	2991499
	1864	6950	56	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9089668
	1864	6950	56	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9618428
	CHEMBL127421	6950	56	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10696085
	CHEMBL127421	6950	56	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	2991499
	CHEMBL127421	6950	56	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9089668
	CHEMBL127421	6950	56	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9618428
	24750192	10689	13	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	18052314
	7777	10689	13	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	18052314
	CHEMBL237236	10689	13	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	18052314
	12324	10683	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	30126274
	145966622	10683	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	30126274
	CHEMBL4210086	10683	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	30126274
	7778	7601	0	None	97	2	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	20444610
	9957516	7601	0	None	97	2	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	20444610
	CHEMBL1094546	7601	0	None	97	2	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	20444610
	1357	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
	1357	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
	1357	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
	1672	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
	1672	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
	1672	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
	224	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
	224	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
	224	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
	896	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
	896	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
	896	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
	CHEMBL45	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
	CHEMBL45	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
	CHEMBL45	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
	DB01065	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
	DB01065	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
	DB01065	9263	139	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
	10220503	10528	0	None	-2	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
	4820	10528	0	None	-2	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
	7393	10528	0	None	-2	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
	CHEMBL2103822	10528	0	None	-2	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
	DB09071	10528	0	None	-2	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
	4004	21193	57	None	-	1	Human	8.0	pKi	None	8.0	Binding	NoneNone	Drug Central	330	9	0	8	2.1	CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC	None
	CHEMBL1200468	21193	57	None	-	1	Human	8.0	pKi	None	8.0	Binding	NoneNone	Drug Central	330	9	0	8	2.1	CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC	None
	1351	9174	21	None	-1	2	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	15302228
	219018	9174	21	None	-1	2	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	15302228
	CHEMBL4079759	9174	21	None	-1	2	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	15302228
	127856	10206	0	None	-3	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	4	1	1	3.3	O=C(C1CCC1)NCCc1cccc2c1cccc2	12764576
	1360	10206	0	None	-3	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	4	1	1	3.3	O=C(C1CCC1)NCCc1cccc2c1cccc2	12764576
	CHEMBL12296	10206	0	None	-3	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	4	1	1	3.3	O=C(C1CCC1)NCCc1cccc2c1cccc2	12764576
	1358	6912	41	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	12764576
	1358	6912	41	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9089668
	1358	6912	41	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9737724
	3976006	6912	41	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	12764576
	3976006	6912	41	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9089668
	3976006	6912	41	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9737724
	CHEMBL285718	6912	41	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	12764576
	CHEMBL285718	6912	41	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9089668
	CHEMBL285718	6912	41	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9737724
	1348	8626	5	None	-100	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10205014
	1348	8626	5	None	-100	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	9089668
	44208891	8626	5	None	-100	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10205014
	44208891	8626	5	None	-100	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	9089668
	CHEMBL3260983	8626	5	None	-100	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10205014
	CHEMBL3260983	8626	5	None	-100	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	9089668
	1354	10209	15	None	-275	2	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	12764576
	22133318	10209	15	None	-275	2	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	12764576
	CHEMBL490188	10209	15	None	-275	2	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	12764576
	1359	8951	21	None	-125	2	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10737738
	5311198	8951	21	None	-125	2	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10737738
	CHEMBL274438	8951	21	None	-125	2	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10737738
	1353	10208	5	None	-112	2	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	12764576
	9998187	10208	5	None	-112	2	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	12764576
	CHEMBL33549	10208	5	None	-112	2	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	12764576
	10849065	6925	8	None	4	2	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	11068946
	1345	6925	8	None	4	2	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	11068946
	CHEMBL126809	6925	8	None	4	2	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	11068946
	1361	10207	0	None	-1	2	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	4	1	2	3.1	CCc1ccc2c(c1)c(CCNC(=O)C)cs2	12764576
	9816339	10207	0	None	-1	2	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	4	1	2	3.1	CCc1ccc2c(c1)c(CCNC(=O)C)cs2	12764576
	1350	8771	0	None	-95	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10737738
	4172142	8771	0	None	-95	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10737738
	CHEMBL10009	8771	0	None	-95	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10737738
	1362	10210	22	None	39	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
	9870523	10210	22	None	39	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
	CHEMBL429392	10210	22	None	39	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
	1355	10211	5	None	70	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
	9806449	10211	5	None	70	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
	CHEMBL14453	10211	5	None	70	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
	1349	8630	0	None	-1	2	Human	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	10696085
	1349	8630	0	None	-1	2	Human	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	9618428
	5311134	8630	0	None	-1	2	Human	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	10696085
	5311134	8630	0	None	-1	2	Human	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	9618428

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)