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Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	169260419	195986	None	0	Human	Functional	pEC50	=	9.6	9.6	-	1	Agonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysisAgonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysis	ChEMBL	377	5	1	5	4.4	C[C@@H](Nc1ncc(-c2cncc(CC(F)(F)F)c2)nn1)c1ccc(F)cc1	10.1021/acs.jmedchem.3c00784
	CHEMBL5414688	195986	None	0	Human	Functional	pEC50	=	9.6	9.6	-	1	Agonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysisAgonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysis	ChEMBL	377	5	1	5	4.4	C[C@@H](Nc1ncc(-c2cncc(CC(F)(F)F)c2)nn1)c1ccc(F)cc1	10.1021/acs.jmedchem.3c00784
	169260355	196629	None	3	Human	Functional	pEC50	=	9.6	9.6	-	1	Agonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysisAgonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysis	ChEMBL	376	5	1	4	5.0	C[C@@H](Nc1cnc(-c2cncc(CC(F)(F)F)c2)cn1)c1ccc(F)cc1	10.1021/acs.jmedchem.3c00784
	CHEMBL5428306	196629	None	3	Human	Functional	pEC50	=	9.6	9.6	-	1	Agonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysisAgonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysis	ChEMBL	376	5	1	4	5.0	C[C@@H](Nc1cnc(-c2cncc(CC(F)(F)F)c2)cn1)c1ccc(F)cc1	10.1021/acs.jmedchem.3c00784
	169260297	196551	None	0	Human	Functional	pEC50	=	9.4	9.4	-	1	Agonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysisAgonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysis	ChEMBL	358	6	1	4	4.7	C[C@@H](Nc1cnc(-c2cncc(CC(F)F)c2)cn1)c1ccc(F)cc1	10.1021/acs.jmedchem.3c00784
	CHEMBL5426486	196551	None	0	Human	Functional	pEC50	=	9.4	9.4	-	1	Agonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysisAgonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysis	ChEMBL	358	6	1	4	4.7	C[C@@H](Nc1cnc(-c2cncc(CC(F)F)c2)cn1)c1ccc(F)cc1	10.1021/acs.jmedchem.3c00784
	169260304	196634	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysisAgonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysis	ChEMBL	307	4	1	3	4.8	Cc1cncc(-c2ccc(N[C@H](C)c3ccc(F)cc3)nc2)c1	10.1021/acs.jmedchem.3c00784
	CHEMBL5428424	196634	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysisAgonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysis	ChEMBL	307	4	1	3	4.8	Cc1cncc(-c2ccc(N[C@H](C)c3ccc(F)cc3)nc2)c1	10.1021/acs.jmedchem.3c00784
	137658912	159536	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Agonist activity at beta-galactosidase enzyme fragment-fused GPR55 (unknown origin) expressed in CHOK1 cells assessed as increase in N-terminal deletion beta-galactosidase mutant-tagged beta arrestin recruitment measured for 1 sec by chemiluminescence based pathhunter assayAgonist activity at beta-galactosidase enzyme fragment-fused GPR55 (unknown origin) expressed in CHOK1 cells assessed as increase in N-terminal deletion beta-galactosidase mutant-tagged beta arrestin recruitment measured for 1 sec by chemiluminescence based pathhunter assay	ChEMBL	577	10	3	7	4.7	COc1ccccc1/C=C/C(=O)NC(=S)Nc1ccc(S(=O)(=O)N(Cc2ccc(CO)o2)c2ccccc2)cc1	10.1016/j.bmc.2017.06.016
	CHEMBL4101162	159536	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Agonist activity at beta-galactosidase enzyme fragment-fused GPR55 (unknown origin) expressed in CHOK1 cells assessed as increase in N-terminal deletion beta-galactosidase mutant-tagged beta arrestin recruitment measured for 1 sec by chemiluminescence based pathhunter assayAgonist activity at beta-galactosidase enzyme fragment-fused GPR55 (unknown origin) expressed in CHOK1 cells assessed as increase in N-terminal deletion beta-galactosidase mutant-tagged beta arrestin recruitment measured for 1 sec by chemiluminescence based pathhunter assay	ChEMBL	577	10	3	7	4.7	COc1ccccc1/C=C/C(=O)NC(=S)Nc1ccc(S(=O)(=O)N(Cc2ccc(CO)o2)c2ccccc2)cc1	10.1016/j.bmc.2017.06.016
	137660243	159378	None	0	Human	Functional	pEC50	=	6	6.0	-	1	Agonist activity at beta-galactosidase enzyme fragment-fused GPR55 (unknown origin) expressed in CHOK1 cells assessed as increase in N-terminal deletion beta-galactosidase mutant-tagged beta arrestin recruitment measured for 1 sec by chemiluminescence based pathhunter assayAgonist activity at beta-galactosidase enzyme fragment-fused GPR55 (unknown origin) expressed in CHOK1 cells assessed as increase in N-terminal deletion beta-galactosidase mutant-tagged beta arrestin recruitment measured for 1 sec by chemiluminescence based pathhunter assay	ChEMBL	476	5	2	5	4.2	CN(c1ccccc1)S(=O)(=O)c1ccc(NC(=S)NC(=O)c2ccc3cccnc3c2)cc1	10.1016/j.bmc.2017.06.016
	CHEMBL4099471	159378	None	0	Human	Functional	pEC50	=	6	6.0	-	1	Agonist activity at beta-galactosidase enzyme fragment-fused GPR55 (unknown origin) expressed in CHOK1 cells assessed as increase in N-terminal deletion beta-galactosidase mutant-tagged beta arrestin recruitment measured for 1 sec by chemiluminescence based pathhunter assayAgonist activity at beta-galactosidase enzyme fragment-fused GPR55 (unknown origin) expressed in CHOK1 cells assessed as increase in N-terminal deletion beta-galactosidase mutant-tagged beta arrestin recruitment measured for 1 sec by chemiluminescence based pathhunter assay	ChEMBL	476	5	2	5	4.2	CN(c1ccccc1)S(=O)(=O)c1ccc(NC(=S)NC(=O)c2ccc3cccnc3c2)cc1	10.1016/j.bmc.2017.06.016
	1724914	47404	None	14	Human	Functional	pEC50	=	6	6.0	-	1	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	474	3	0	5	7.2	O=C(CSc1nc2ccccc2s1)N1c2ccccc2Sc2ccc(C(F)(F)F)cc21	nan
	CHEMBL1544821	47404	None	14	Human	Functional	pEC50	=	6	6.0	-	1	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	474	3	0	5	7.2	O=C(CSc1nc2ccccc2s1)N1c2ccccc2Sc2ccc(C(F)(F)F)cc21	nan
	1172037	53300	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	461	6	1	8	5.1	COc1ccc2cc(C)c3nnc(SCC(=O)Nc4nc(-c5ccccc5)cs4)n3c2c1	nan
	CHEMBL1599391	53300	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	461	6	1	8	5.1	COc1ccc2cc(C)c3nnc(SCC(=O)Nc4nc(-c5ccccc5)cs4)n3c2c1	nan
	16320697	47493	None	2	Human	Functional	pEC50	=	6.0	6.0	-	1	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	472	7	1	7	5.4	COc1ccc(C2=NN(c3nc(-c4ccc(CNC(C)=O)cc4)cs3)C(c3ccco3)C2)cc1	nan
	CHEMBL1545460	47493	None	2	Human	Functional	pEC50	=	6.0	6.0	-	1	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	472	7	1	7	5.4	COc1ccc(C2=NN(c3nc(-c4ccc(CNC(C)=O)cc4)cs3)C(c3ccco3)C2)cc1	nan
	5336094	45419	None	5	Human	Functional	pEC50	=	6.0	6.0	2	2	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	419	8	1	6	5.5	CCOC(=O)/C(=C\c1ccccc1)C(=O)c1cc(C(C)=O)c(Nc2ccccc2)s1	nan
	CHEMBL1527447	45419	None	5	Human	Functional	pEC50	=	6.0	6.0	2	2	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	419	8	1	6	5.5	CCOC(=O)/C(=C\c1ccccc1)C(=O)c1cc(C(C)=O)c(Nc2ccccc2)s1	nan
	4562786	49072	None	6	Human	Functional	pEC50	=	5.0	5.0	-	1	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	329	4	2	8	1.5	CN1CCN(c2nc(Nc3ccccc3)nc(N)c2[N+](=O)[O-])CC1	nan
	CHEMBL1561279	49072	None	6	Human	Functional	pEC50	=	5.0	5.0	-	1	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	329	4	2	8	1.5	CN1CCN(c2nc(Nc3ccccc3)nc(N)c2[N+](=O)[O-])CC1	nan
	16060986	24116	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	440	10	0	4	5.0	COc1ccc(SC[C@H](CC(C)C)N2CCN(CCc3ccccc3)CCC2=O)cc1	nan
	CHEMBL1338630	24116	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	440	10	0	4	5.0	COc1ccc(SC[C@H](CC(C)C)N2CCN(CCc3ccccc3)CCC2=O)cc1	nan
	3662261	33335	None	5	Human	Functional	pEC50	=	5.0	5.0	1	3	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	401	6	2	6	3.2	CC/C(Nc1ccc(OC)cc1OC)=C1/C(=O)NC(=O)N(C2CCCCC2)C1=O	nan
	CHEMBL1418843	33335	None	5	Human	Functional	pEC50	=	5.0	5.0	1	3	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	401	6	2	6	3.2	CC/C(Nc1ccc(OC)cc1OC)=C1/C(=O)NC(=O)N(C2CCCCC2)C1=O	nan
	169260346	195381	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysisAgonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysis	ChEMBL	361	4	1	3	5.5	C[C@@H](Nc1ccc(-c2cncc(C(F)(F)F)c2)cn1)c1ccc(F)cc1	10.1021/acs.jmedchem.3c00784
	CHEMBL5402444	195381	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysisAgonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysis	ChEMBL	361	4	1	3	5.5	C[C@@H](Nc1ccc(-c2cncc(C(F)(F)F)c2)cn1)c1ccc(F)cc1	10.1021/acs.jmedchem.3c00784
	24817051	52058	None	5	Human	Functional	pEC50	=	5.0	5.0	-	1	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	392	7	0	4	4.9	CCCc1ccc2oc(C(=O)N(Cc3ccncc3)CC3CCCO3)c(C)c2c1	nan
	CHEMBL1587026	52058	None	5	Human	Functional	pEC50	=	5.0	5.0	-	1	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	392	7	0	4	4.9	CCCc1ccc2oc(C(=O)N(Cc3ccncc3)CC3CCCO3)c(C)c2c1	nan
	1792197	931	None	16	Human	Functional	pEC50	=	6.9	6.9	-	1	PUBCHEM_BIOASSAY: SAR analysis of selective Agonists of GPR55 using an Image-Based Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965]PUBCHEM_BIOASSAY: SAR analysis of selective Agonists of GPR55 using an Image-Based Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965]	ChEMBL	481	7	2	5	4.0	COc1ccccc1/C=C/C(=O)NC(=S)Nc1ccc(cc1)S(=O)(=O)N(c1ccccc1)C	nan
	5563	931	None	16	Human	Functional	pEC50	=	6.9	6.9	-	1	PUBCHEM_BIOASSAY: SAR analysis of selective Agonists of GPR55 using an Image-Based Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965]PUBCHEM_BIOASSAY: SAR analysis of selective Agonists of GPR55 using an Image-Based Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965]	ChEMBL	481	7	2	5	4.0	COc1ccccc1/C=C/C(=O)NC(=S)Nc1ccc(cc1)S(=O)(=O)N(c1ccccc1)C	nan
	CHEMBL1532240	931	None	16	Human	Functional	pEC50	=	6.9	6.9	-	1	PUBCHEM_BIOASSAY: SAR analysis of selective Agonists of GPR55 using an Image-Based Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965]PUBCHEM_BIOASSAY: SAR analysis of selective Agonists of GPR55 using an Image-Based Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965]	ChEMBL	481	7	2	5	4.0	COc1ccccc1/C=C/C(=O)NC(=S)Nc1ccc(cc1)S(=O)(=O)N(c1ccccc1)C	nan
	2964873	33177	None	6	Human	Functional	pEC50	=	5.9	5.9	-	1	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	377	5	1	4	5.6	COc1cc2c(cc1NC(=O)CSc1ccc(C)cc1)oc1ccccc12	nan
	CHEMBL1417504	33177	None	6	Human	Functional	pEC50	=	5.9	5.9	-	1	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	377	5	1	4	5.6	COc1cc2c(cc1NC(=O)CSc1ccc(C)cc1)oc1ccccc12	nan
	16253428	59187	None	4	Human	Functional	pEC50	=	4.9	4.9	-	1	PUBCHEM_BIOASSAY: SAR analysis of selective Agonists of GPR55 using an Image-Based Assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965]PUBCHEM_BIOASSAY: SAR analysis of selective Agonists of GPR55 using an Image-Based Assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965]	ChEMBL	445	5	1	7	5.4	Cc1ccc(-c2csc(NC(=O)CSc3nnc4cc(C)c5ccccc5n34)n2)cc1	nan
	CHEMBL1699880	59187	None	4	Human	Functional	pEC50	=	4.9	4.9	-	1	PUBCHEM_BIOASSAY: SAR analysis of selective Agonists of GPR55 using an Image-Based Assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965]PUBCHEM_BIOASSAY: SAR analysis of selective Agonists of GPR55 using an Image-Based Assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965]	ChEMBL	445	5	1	7	5.4	Cc1ccc(-c2csc(NC(=O)CSc3nnc4cc(C)c5ccccc5n34)n2)cc1	nan
	1724914	47404	None	14	Human	Functional	pEC50	=	5.9	5.9	-	1	PUBCHEM_BIOASSAY: SAR analysis of selective Agonists of GPR55 using an Image-Based Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965]PUBCHEM_BIOASSAY: SAR analysis of selective Agonists of GPR55 using an Image-Based Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965]	ChEMBL	474	3	0	5	7.2	O=C(CSc1nc2ccccc2s1)N1c2ccccc2Sc2ccc(C(F)(F)F)cc21	nan
	CHEMBL1544821	47404	None	14	Human	Functional	pEC50	=	5.9	5.9	-	1	PUBCHEM_BIOASSAY: SAR analysis of selective Agonists of GPR55 using an Image-Based Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965]PUBCHEM_BIOASSAY: SAR analysis of selective Agonists of GPR55 using an Image-Based Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965]	ChEMBL	474	3	0	5	7.2	O=C(CSc1nc2ccccc2s1)N1c2ccccc2Sc2ccc(C(F)(F)F)cc21	nan
	127037894	137200	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human GPR55 expressed in HEK293 cells assessed as calcium signalling by fura 2-based digital epifluorescence microscopyAgonist activity at human GPR55 expressed in HEK293 cells assessed as calcium signalling by fura 2-based digital epifluorescence microscopy	ChEMBL	515	7	3	4	5.3	Cc1ccc(CNS(=O)(=O)c2ccc(NC(=S)NC(=O)c3ccc(-c4ccccc4)cc3)cc2)cc1	10.1016/j.ejmech.2015.10.050
	CHEMBL3747626	137200	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human GPR55 expressed in HEK293 cells assessed as calcium signalling by fura 2-based digital epifluorescence microscopyAgonist activity at human GPR55 expressed in HEK293 cells assessed as calcium signalling by fura 2-based digital epifluorescence microscopy	ChEMBL	515	7	3	4	5.3	Cc1ccc(CNS(=O)(=O)c2ccc(NC(=S)NC(=O)c3ccc(-c4ccccc4)cc3)cc2)cc1	10.1016/j.ejmech.2015.10.050
	6412316	42264	None	12	Human	Functional	pEC50	=	4.9	4.9	2	2	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	403	5	0	6	5.1	CCOC(=O)c1nnc(-c2ccc(C)cc2)nc1Oc1ccc(Cl)cc1Cl	nan
	CHEMBL1497403	42264	None	12	Human	Functional	pEC50	=	4.9	4.9	2	2	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	403	5	0	6	5.1	CCOC(=O)c1nnc(-c2ccc(C)cc2)nc1Oc1ccc(Cl)cc1Cl	nan
	1959655	34666	None	18	Human	Functional	pEC50	=	4.9	4.9	-1	2	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	406	3	0	5	6.2	O=C(CSc1nc2ccccc2s1)N1c2ccccc2Sc2ccccc21	nan
	CHEMBL1430016	34666	None	18	Human	Functional	pEC50	=	4.9	4.9	-1	2	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	406	3	0	5	6.2	O=C(CSc1nc2ccccc2s1)N1c2ccccc2Sc2ccccc21	nan
	3230764	53915	None	2	Human	Functional	pEC50	=	4.9	4.9	-	1	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	375	4	0	7	1.3	O=CN1CCN(c2ncnc3c2nnn3Cc2c(F)cccc2Cl)CC1	nan
	CHEMBL1605039	53915	None	2	Human	Functional	pEC50	=	4.9	4.9	-	1	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	375	4	0	7	1.3	O=CN1CCN(c2ncnc3c2nnn3Cc2c(F)cccc2Cl)CC1	nan
	1130106	46843	None	11	Human	Functional	pEC50	=	5.9	5.9	-	1	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	403	3	0	5	5.5	Cn1c(SCC(=O)N2c3ccccc3Sc3ccccc32)nc2ccccc21	nan
	CHEMBL1540265	46843	None	11	Human	Functional	pEC50	=	5.9	5.9	-	1	PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279]	ChEMBL	403	3	0	5	5.5	Cn1c(SCC(=O)N2c3ccccc3Sc3ccccc32)nc2ccccc21	nan
	169260368	196455	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysisAgonist activity at human GPR55 expressed in human HEK293 cells assessed as effect on calcium flux incubated for 5 mins by FLIPR analysis	ChEMBL	333	5	1	3	5.3	C[C@@H](Nc1ccc(-c2cncc(C3CC3)c2)cn1)c1ccc(F)cc1	10.1021/acs.jmedchem.3c00784

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Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	127030161	138925	None	0	Human	Binding	pEC50	=	9.4	9.4	-	1	Partial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assayPartial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assay	ChEMBL	440	5	0	7	2.5	COc1ccc2c(c1)OC(C)(C)c1cn(CCN3CCN(C(=O)C4CCCO4)CC3)nc1-2	10.1021/acs.jmedchem.5b01331
	CHEMBL3781437	138925	None	0	Human	Binding	pEC50	=	9.4	9.4	-	1	Partial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assayPartial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assay	ChEMBL	440	5	0	7	2.5	COc1ccc2c(c1)OC(C)(C)c1cn(CCN3CCN(C(=O)C4CCCO4)CC3)nc1-2	10.1021/acs.jmedchem.5b01331
	127034073	138962	None	0	Human	Binding	pEC50	=	9.3	9.3	-	1	Partial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assayPartial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assay	ChEMBL	452	5	0	7	3.7	COc1ccc2c(c1)OC(C)(C)c1cn(CCN3CCN(C(=O)c4cccs4)CC3)nc1-2	10.1021/acs.jmedchem.5b01331
	CHEMBL3781953	138962	None	0	Human	Binding	pEC50	=	9.3	9.3	-	1	Partial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assayPartial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assay	ChEMBL	452	5	0	7	3.7	COc1ccc2c(c1)OC(C)(C)c1cn(CCN3CCN(C(=O)c4cccs4)CC3)nc1-2	10.1021/acs.jmedchem.5b01331
	127034071	138809	None	0	Human	Binding	pEC50	=	9.2	9.2	-	1	Partial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assayPartial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assay	ChEMBL	446	5	0	6	3.6	COc1ccc2c(c1)OC(C)(C)c1cn(CCN3CCN(C(=O)c4ccccc4)CC3)nc1-2	10.1021/acs.jmedchem.5b01331
	CHEMBL3779969	138809	None	0	Human	Binding	pEC50	=	9.2	9.2	-	1	Partial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assayPartial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assay	ChEMBL	446	5	0	6	3.6	COc1ccc2c(c1)OC(C)(C)c1cn(CCN3CCN(C(=O)c4ccccc4)CC3)nc1-2	10.1021/acs.jmedchem.5b01331
	127029838	138932	None	0	Human	Binding	pEC50	=	9.2	9.2	-	1	Partial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assayPartial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assay	ChEMBL	426	4	0	6	3.4	COc1ccc2c(c1)OC(C)(C)c1cn(CCN3CCN(C(=O)C(C)(C)C)CC3)nc1-2	10.1021/acs.jmedchem.5b01331
	CHEMBL3781521	138932	None	0	Human	Binding	pEC50	=	9.2	9.2	-	1	Partial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assayPartial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assay	ChEMBL	426	4	0	6	3.4	COc1ccc2c(c1)OC(C)(C)c1cn(CCN3CCN(C(=O)C(C)(C)C)CC3)nc1-2	10.1021/acs.jmedchem.5b01331
	127034069	138902	None	0	Human	Binding	pEC50	=	9.1	9.1	-	1	Partial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assayPartial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assay	ChEMBL	436	5	0	7	3.2	COc1ccc2c(c1)OC(C)(C)c1cn(CCN3CCN(C(=O)c4ccco4)CC3)nc1-2	10.1021/acs.jmedchem.5b01331
	CHEMBL3781158	138902	None	0	Human	Binding	pEC50	=	9.1	9.1	-	1	Partial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assayPartial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assay	ChEMBL	436	5	0	7	3.2	COc1ccc2c(c1)OC(C)(C)c1cn(CCN3CCN(C(=O)c4ccco4)CC3)nc1-2	10.1021/acs.jmedchem.5b01331
	127030160	138808	None	0	Human	Binding	pEC50	=	8.9	8.9	-	0	Partial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assayPartial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assay	ChEMBL	476	7	0	7	3.4	COc1ccc2c(c1)OC(C)(C)c1cn(CCN3CCN(C(=O)COc4ccccc4)CC3)nc1-2	10.1021/acs.jmedchem.5b01331
	CHEMBL3779954	138808	None	0	Human	Binding	pEC50	=	8.9	8.9	-	0	Partial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assayPartial agonist activity at recombinant human GPR55 expressed in HEK293 cells after 5 mins by xCELLigence assay	ChEMBL	476	7	0	7	3.4	COc1ccc2c(c1)OC(C)(C)c1cn(CCN3CCN(C(=O)COc4ccccc4)CC3)nc1-2	10.1021/acs.jmedchem.5b01331
	90667664	109576	None	0	Human	Binding	pEC50	=	6	6.0	-	0	Agonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	620	21	7	11	2.4	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O[C@H](CO)COP(=O)(O)O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O	10.1039/C3MD00394A
	CHEMBL3221204	109576	None	0	Human	Binding	pEC50	=	6	6.0	-	0	Agonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	620	21	7	11	2.4	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O[C@H](CO)COP(=O)(O)O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O	10.1039/C3MD00394A
	73353471	90655	None	0	Human	Binding	pEC50	=	6	6.0	-	0	Agonist activity at human GPR55 transfected in CHO cells after 90 mins by beta-arrestin translocation assay relative to LPIAgonist activity at human GPR55 transfected in CHO cells after 90 mins by beta-arrestin translocation assay relative to LPI	ChEMBL	620	21	7	11	2.4	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O[C@H](CO)COP(=O)(O)O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O	10.1021/jm4005175
	CHEMBL2387746	90655	None	0	Human	Binding	pEC50	=	6	6.0	-	0	Agonist activity at human GPR55 transfected in CHO cells after 90 mins by beta-arrestin translocation assay relative to LPIAgonist activity at human GPR55 transfected in CHO cells after 90 mins by beta-arrestin translocation assay relative to LPI	ChEMBL	620	21	7	11	2.4	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O[C@H](CO)COP(=O)(O)O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O	10.1021/jm4005175
	11338511	109570	None	0	Human	Binding	pEC50	=	5.0	5.0	-	2	Agonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	398	4	0	4	5.0	O=C1/C(=C/c2cccc(OCc3ccc(Cl)cc3)c2)N=C2SCCCCN12	10.1039/C3MD00394A
	CHEMBL3221198	109570	None	0	Human	Binding	pEC50	=	5.0	5.0	-	2	Agonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	398	4	0	4	5.0	O=C1/C(=C/c2cccc(OCc3ccc(Cl)cc3)c2)N=C2SCCCCN12	10.1039/C3MD00394A
	1792197	931	None	16	Human	Binding	pEC50	=	7.0	7.0	-	0	Agonist activity at HA-epitope-tagged variant of GPR55E with serine enhanced C terminus (unknown origin) expressed in human U2OS cells assessed as increase in GFP-tagged beta arrestin2 recruitment after 75 mins by fluorescence assayAgonist activity at HA-epitope-tagged variant of GPR55E with serine enhanced C terminus (unknown origin) expressed in human U2OS cells assessed as increase in GFP-tagged beta arrestin2 recruitment after 75 mins by fluorescence assay	ChEMBL	481	7	2	5	4.0	COc1ccccc1/C=C/C(=O)NC(=S)Nc1ccc(cc1)S(=O)(=O)N(c1ccccc1)C	10.1016/j.bmc.2017.06.016
	5563	931	None	16	Human	Binding	pEC50	=	7.0	7.0	-	0	Agonist activity at HA-epitope-tagged variant of GPR55E with serine enhanced C terminus (unknown origin) expressed in human U2OS cells assessed as increase in GFP-tagged beta arrestin2 recruitment after 75 mins by fluorescence assayAgonist activity at HA-epitope-tagged variant of GPR55E with serine enhanced C terminus (unknown origin) expressed in human U2OS cells assessed as increase in GFP-tagged beta arrestin2 recruitment after 75 mins by fluorescence assay	ChEMBL	481	7	2	5	4.0	COc1ccccc1/C=C/C(=O)NC(=S)Nc1ccc(cc1)S(=O)(=O)N(c1ccccc1)C	10.1016/j.bmc.2017.06.016
	CHEMBL1532240	931	None	16	Human	Binding	pEC50	=	7.0	7.0	-	0	Agonist activity at HA-epitope-tagged variant of GPR55E with serine enhanced C terminus (unknown origin) expressed in human U2OS cells assessed as increase in GFP-tagged beta arrestin2 recruitment after 75 mins by fluorescence assayAgonist activity at HA-epitope-tagged variant of GPR55E with serine enhanced C terminus (unknown origin) expressed in human U2OS cells assessed as increase in GFP-tagged beta arrestin2 recruitment after 75 mins by fluorescence assay	ChEMBL	481	7	2	5	4.0	COc1ccccc1/C=C/C(=O)NC(=S)Nc1ccc(cc1)S(=O)(=O)N(c1ccccc1)C	10.1016/j.bmc.2017.06.016
	56649300	157863	None	30	Rat	Binding	pEC50	=	6.9	6.9	-	0	CHO-based cAMP assay (rat)CHO-based cAMP assay (rat)	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL4507305
	CHEMBL4082756	157863	None	30	Rat	Binding	pEC50	=	6.9	6.9	-	0	CHO-based cAMP assay (rat)CHO-based cAMP assay (rat)	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL4507305
	16078	1362	None	15	Human	Binding	pEC50	=	4.9	4.9	-	6	Agonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1039/C3MD00394A
	16078.0	1362	None	15	Human	Binding	pEC50	=	4.9	4.9	-	6	Agonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1039/C3MD00394A
	2424	1362	None	15	Human	Binding	pEC50	=	4.9	4.9	-	6	Agonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1039/C3MD00394A
	4109	1362	None	15	Human	Binding	pEC50	=	4.9	4.9	-	6	Agonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1039/C3MD00394A
	CHEMBL465	1362	None	15	Human	Binding	pEC50	=	4.9	4.9	-	6	Agonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1039/C3MD00394A
	DB00470	1362	None	15	Human	Binding	pEC50	=	4.9	4.9	-	6	Agonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	314	4	1	2	5.7	CCCCCc1cc(O)c2c(c1)OC([C@H]1[C@H]2C=C(C)CC1)(C)C	10.1039/C3MD00394A
	127034071	138809	None	0	Human	Binding	pEC50	=	7.8	7.8	-	1	Antagonist activity at recombinant human GPR55 expressed in HEK293 cells assessed as inhibition of LPI mediated receptor activation by measuring LPI EC50 after 5 mins by xCELLigence assay (Rvb = 1.6 to 4.1 nM)Antagonist activity at recombinant human GPR55 expressed in HEK293 cells assessed as inhibition of LPI mediated receptor activation by measuring LPI EC50 after 5 mins by xCELLigence assay (Rvb = 1.6 to 4.1 nM)	ChEMBL	446	5	0	6	3.6	COc1ccc2c(c1)OC(C)(C)c1cn(CCN3CCN(C(=O)c4ccccc4)CC3)nc1-2	10.1021/acs.jmedchem.5b01331
	CHEMBL3779969	138809	None	0	Human	Binding	pEC50	=	7.8	7.8	-	1	Antagonist activity at recombinant human GPR55 expressed in HEK293 cells assessed as inhibition of LPI mediated receptor activation by measuring LPI EC50 after 5 mins by xCELLigence assay (Rvb = 1.6 to 4.1 nM)Antagonist activity at recombinant human GPR55 expressed in HEK293 cells assessed as inhibition of LPI mediated receptor activation by measuring LPI EC50 after 5 mins by xCELLigence assay (Rvb = 1.6 to 4.1 nM)	ChEMBL	446	5	0	6	3.6	COc1ccc2c(c1)OC(C)(C)c1cn(CCN3CCN(C(=O)c4ccccc4)CC3)nc1-2	10.1021/acs.jmedchem.5b01331
	56649300	157863	None	30	Rat	Binding	pEC50	=	6.8	6.8	-	0	cAMP increase in rat primary cultured striatal neuronscAMP increase in rat primary cultured striatal neurons	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL4507305
	CHEMBL4082756	157863	None	30	Rat	Binding	pEC50	=	6.8	6.8	-	0	cAMP increase in rat primary cultured striatal neuronscAMP increase in rat primary cultured striatal neurons	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL4507305
	5561	1884	None	13	Human	Binding	pEC50	=	6.8	6.8	-	0	Agonist activity at human GPR55 expressed in Saccharomyces cerevisiae by beta-galactosidase reporter assayAgonist activity at human GPR55 expressed in Saccharomyces cerevisiae by beta-galactosidase reporter assay	ChEMBL	471	4	1	5	3.6	Fc1ccc(cc1)c1ccc(cc1C(=O)N1CCN(CC1)c1ccc(cc1F)N)S(=O)(=O)C	10.1016/j.ejmech.2015.10.050
	59822766	1884	None	13	Human	Binding	pEC50	=	6.8	6.8	-	0	Agonist activity at human GPR55 expressed in Saccharomyces cerevisiae by beta-galactosidase reporter assayAgonist activity at human GPR55 expressed in Saccharomyces cerevisiae by beta-galactosidase reporter assay	ChEMBL	471	4	1	5	3.6	Fc1ccc(cc1)c1ccc(cc1C(=O)N1CCN(CC1)c1ccc(cc1F)N)S(=O)(=O)C	10.1016/j.ejmech.2015.10.050
	CHEMBL3747673	1884	None	13	Human	Binding	pEC50	=	6.8	6.8	-	0	Agonist activity at human GPR55 expressed in Saccharomyces cerevisiae by beta-galactosidase reporter assayAgonist activity at human GPR55 expressed in Saccharomyces cerevisiae by beta-galactosidase reporter assay	ChEMBL	471	4	1	5	3.6	Fc1ccc(cc1)c1ccc(cc1C(=O)N1CCN(CC1)c1ccc(cc1F)N)S(=O)(=O)C	10.1016/j.ejmech.2015.10.050
	1172084	929	None	10	Human	Binding	pEC50	=	6.8	6.8	-	0	Agonist activity at HA-epitope-tagged variant of GPR55E with serine enhanced C terminus (unknown origin) expressed in human U2OS cells assessed as increase in GFP-tagged beta arrestin2 recruitment after 75 mins by fluorescence assayAgonist activity at HA-epitope-tagged variant of GPR55E with serine enhanced C terminus (unknown origin) expressed in human U2OS cells assessed as increase in GFP-tagged beta arrestin2 recruitment after 75 mins by fluorescence assay	ChEMBL	479	6	1	8	5.2	COc1ccc2c(c1)n1c(SCC(=O)Nc3scc(n3)c3ccc(cc3)F)nnc1c(c2)C	10.1016/j.bmc.2017.06.016
	5564	929	None	10	Human	Binding	pEC50	=	6.8	6.8	-	0	Agonist activity at HA-epitope-tagged variant of GPR55E with serine enhanced C terminus (unknown origin) expressed in human U2OS cells assessed as increase in GFP-tagged beta arrestin2 recruitment after 75 mins by fluorescence assayAgonist activity at HA-epitope-tagged variant of GPR55E with serine enhanced C terminus (unknown origin) expressed in human U2OS cells assessed as increase in GFP-tagged beta arrestin2 recruitment after 75 mins by fluorescence assay	ChEMBL	479	6	1	8	5.2	COc1ccc2c(c1)n1c(SCC(=O)Nc3scc(n3)c3ccc(cc3)F)nnc1c(c2)C	10.1016/j.bmc.2017.06.016
	CHEMBL1718432	929	None	10	Human	Binding	pEC50	=	6.8	6.8	-	0	Agonist activity at HA-epitope-tagged variant of GPR55E with serine enhanced C terminus (unknown origin) expressed in human U2OS cells assessed as increase in GFP-tagged beta arrestin2 recruitment after 75 mins by fluorescence assayAgonist activity at HA-epitope-tagged variant of GPR55E with serine enhanced C terminus (unknown origin) expressed in human U2OS cells assessed as increase in GFP-tagged beta arrestin2 recruitment after 75 mins by fluorescence assay	ChEMBL	479	6	1	8	5.2	COc1ccc2c(c1)n1c(SCC(=O)Nc3scc(n3)c3ccc(cc3)F)nnc1c(c2)C	10.1016/j.bmc.2017.06.016
	142635551	174134	None	0	Human	Binding	pEC50	=	5.8	5.8	-	0	Inverse agonist activity at GPR55 in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assayInverse agonist activity at GPR55 in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	ChEMBL	307	1	2	5	2.4	O=C1C(Cl)=C(N2CCCCC2)C(=O)c2c(O)ccc(O)c21	10.1021/acsmedchemlett.8b00333
	CHEMBL4543362	174134	None	0	Human	Binding	pEC50	=	5.8	5.8	-	0	Inverse agonist activity at GPR55 in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assayInverse agonist activity at GPR55 in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	ChEMBL	307	1	2	5	2.4	O=C1C(Cl)=C(N2CCCCC2)C(=O)c2c(O)ccc(O)c21	10.1021/acsmedchemlett.8b00333
	104895	1184	None	15	Human	Binding	pEC50	=	5.8	5.8	-	4	Agonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	376	10	3	3	5.7	CCCCCCC(c1ccc(c(c1)O)[C@@H]1C[C@H](O)CC[C@H]1CCCO)(C)C	10.1039/C3MD00394A
	730	1184	None	15	Human	Binding	pEC50	=	5.8	5.8	-	4	Agonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	376	10	3	3	5.7	CCCCCCC(c1ccc(c(c1)O)[C@@H]1C[C@H](O)CC[C@H]1CCCO)(C)C	10.1039/C3MD00394A
	734	1184	None	15	Human	Binding	pEC50	=	5.8	5.8	-	4	Agonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	376	10	3	3	5.7	CCCCCCC(c1ccc(c(c1)O)[C@@H]1C[C@H](O)CC[C@H]1CCCO)(C)C	10.1039/C3MD00394A
	CHEMBL559612	1184	None	15	Human	Binding	pEC50	=	5.8	5.8	-	4	Agonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation methodAgonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	376	10	3	3	5.7	CCCCCCC(c1ccc(c(c1)O)[C@@H]1C[C@H](O)CC[C@H]1CCCO)(C)C	10.1039/C3MD00394A
	127030160	138808	None	0	Human	Binding	pEC50	=	7.7	7.7	-	0	Antagonist activity at recombinant human GPR55 expressed in HEK293 cells assessed as inhibition of LPI mediated receptor activation by measuring LPI EC50 after 5 mins by xCELLigence assay (Rvb = 1.6 to 4.1 nM)Antagonist activity at recombinant human GPR55 expressed in HEK293 cells assessed as inhibition of LPI mediated receptor activation by measuring LPI EC50 after 5 mins by xCELLigence assay (Rvb = 1.6 to 4.1 nM)	ChEMBL	476	7	0	7	3.4	COc1ccc2c(c1)OC(C)(C)c1cn(CCN3CCN(C(=O)COc4ccccc4)CC3)nc1-2	10.1021/acs.jmedchem.5b01331
	CHEMBL3779954	138808	None	0	Human	Binding	pEC50	=	7.7	7.7	-	0	Antagonist activity at recombinant human GPR55 expressed in HEK293 cells assessed as inhibition of LPI mediated receptor activation by measuring LPI EC50 after 5 mins by xCELLigence assay (Rvb = 1.6 to 4.1 nM)Antagonist activity at recombinant human GPR55 expressed in HEK293 cells assessed as inhibition of LPI mediated receptor activation by measuring LPI EC50 after 5 mins by xCELLigence assay (Rvb = 1.6 to 4.1 nM)	ChEMBL	476	7	0	7	3.4	COc1ccc2c(c1)OC(C)(C)c1cn(CCN3CCN(C(=O)COc4ccccc4)CC3)nc1-2	10.1021/acs.jmedchem.5b01331
	127034068	138946	None	0	Human	Binding	pEC50	=	7.7	7.7	-	0	Antagonist activity at recombinant human GPR55 expressed in HEK293 cells assessed as inhibition of LPI mediated receptor activation by measuring LPI EC50 after 5 mins by xCELLigence assay (Rvb = 1.6 to 4.1 nM)Antagonist activity at recombinant human GPR55 expressed in HEK293 cells assessed as inhibition of LPI mediated receptor activation by measuring LPI EC50 after 5 mins by xCELLigence assay (Rvb = 1.6 to 4.1 nM)	ChEMBL	436	5	0	7	3.2	COc1ccc2c(c1)OC(C)(C)c1cnn(CCN3CCN(C(=O)c4ccco4)CC3)c1-2	10.1021/acs.jmedchem.5b01331
	CHEMBL3781764	138946	None	0	Human	Binding	pEC50	=	7.7	7.7	-	0	Antagonist activity at recombinant human GPR55 expressed in HEK293 cells assessed as inhibition of LPI mediated receptor activation by measuring LPI EC50 after 5 mins by xCELLigence assay (Rvb = 1.6 to 4.1 nM)Antagonist activity at recombinant human GPR55 expressed in HEK293 cells assessed as inhibition of LPI mediated receptor activation by measuring LPI EC50 after 5 mins by xCELLigence assay (Rvb = 1.6 to 4.1 nM)	ChEMBL	436	5	0	7	3.2	COc1ccc2c(c1)OC(C)(C)c1cnn(CCN3CCN(C(=O)c4ccco4)CC3)c1-2	10.1021/acs.jmedchem.5b01331
	127034069	138902	None	0	Human	Binding	pEC50	=	7.7	7.7	-	1	Antagonist activity at recombinant human GPR55 expressed in HEK293 cells assessed as inhibition of LPI mediated receptor activation by measuring LPI EC50 after 5 mins by xCELLigence assay (Rvb = 1.6 to 4.1 nM)Antagonist activity at recombinant human GPR55 expressed in HEK293 cells assessed as inhibition of LPI mediated receptor activation by measuring LPI EC50 after 5 mins by xCELLigence assay (Rvb = 1.6 to 4.1 nM)	ChEMBL	436	5	0	7	3.2	COc1ccc2c(c1)OC(C)(C)c1cn(CCN3CCN(C(=O)c4ccco4)CC3)nc1-2	10.1021/acs.jmedchem.5b01331

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Ligand source activities (1 row/activity)