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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Δ⁹-tetrahydrocannabinol	1362	None	15	Human	Binding	EC50	=	14200.00	4.85	-	9	Agonist activity at human GPR55 expressed in CHO cells assessed as induction of LPI-induced beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation method	ChEMBL	314.2	4	1	2	5.74	CCCCCc1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(C)=C[C@@H]21	https://dx.doi.org/10.1039/C3MD00394A
Δ⁹-tetrahydrocannabinol	1362	None	15	Human	Binding	IC50	=	14200.00	4.85	-	9	Antagonist activity at human GPR55 transfected in CHO cells assessed as inhibition of LPI-induced beta-arrestin recruitment incubated 60 mins prior to LPI addition by beta-arrestin translocation assay	ChEMBL	314.2	4	1	2	5.74	CCCCCc1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(C)=C[C@@H]21	https://dx.doi.org/10.1021/jm4005175
cannabidiol	788	None	26	Human	Binding	EC50	=	445.00	6.35	-	23	Binding affinity to GPR55	ChEMBL	314.2	6	2	2	5.85	C=C(C)[C@@H]1CCC(C)=C[C@H]1c1c(O)cc(CCCCC)cc1O	https://dx.doi.org/10.1021/jm9018756
CANNABIDIVARIN	90652	None	24	Human	Binding	EC50	=	400.00	6.40	-	5	Binding affinity to human GPR55 expressed in HEK293 cells assessed as LPI-stimulated ERK1/2 phosphorylation	ChEMBL	286.2	4	2	2	5.07	C=C(C)[C@@H]1CCC(C)=C[C@H]1c1c(O)cc(CCC)cc1O	https://dx.doi.org/10.1021/acs.jnatprod.0c00965
CHEMBL1402920	31462	None	30	Human	Binding	IC50	=	2020.00	5.70	-	1	Antagonist activity at beta-galactosidase fused human GPR55 expressed in CHO cells assessed as inhibition of LPI-induced receptor activation by measuring beta-arrestin 2 recruitment incubated for 90 mins by PathHunter chemiluminescence based assay	ChEMBL	382.1	2	0	6	3.43	Cc1nc(N2CCN(C(=O)c3ccco3)CC2)c2c3c(sc2n1)CCCC3	https://dx.doi.org/10.1021/acsmedchemlett.2c00325
CHEMBL1402920	31462	None	30	Human	Binding	IC50	=	7500.00	5.12	-	1	Antagonist activity at human GPR55 expressed in HEK293 cells coexpressing serum response element assessed as inhibition of LPI-induced MAPK/ERK signalling pathway by measuring SRE response incubated for 5 hrs in serum-free medium by luciferin based bioluminescence analysis	ChEMBL	382.1	2	0	6	3.43	Cc1nc(N2CCN(C(=O)c3ccco3)CC2)c2c3c(sc2n1)CCCC3	https://dx.doi.org/10.1021/acsmedchemlett.2c00325
CHEMBL1402920	31462	None	30	Human	Binding	IC50	=	700.00	6.16	-	1	Antagonist activity at GPR55 (unknown origin) by beta-arrestin recruitment assay	ChEMBL	382.1	2	0	6	3.43	Cc1nc(N2CCN(C(=O)c3ccco3)CC2)c2c3c(sc2n1)CCCC3	https://dx.doi.org/10.1021/acsmedchemlett.2c00325
CHEMBL1484306	40687	None	3	Human	Binding	IC50	=	430.00	6.37	-	4	Antagonist activity at human GPR55 expressed in human U2OS cells assessed as inhibition of LPI-induced receptor activation by measuring beta-arrestin 2 recruitment preincubated for 30 mins followed by LPI addition and measured after 75 mins by microplate reader analysis	ChEMBL	396.2	2	0	6	3.68	Cc1nc(N2CCN(C(=O)c3ccco3)CC2)c2c3c(sc2n1)CC(C)CC3	https://dx.doi.org/10.1021/acsmedchemlett.2c00325
CHEMBL1507657	43426	None	1	Human	Binding	IC50	=	860.00	6.07	-	3	Antagonist activity at human GPR55 expressed in human U2OS cells assessed as inhibition of LPI-induced receptor activation by measuring beta-arrestin 2 recruitment preincubated for 30 mins followed by LPI addition and measured after 75 mins by microplate reader analysis	ChEMBL	408.2	3	0	6	4.00	O=C(c1ccco1)N1CCN(c2nc(C3CC3)nc3sc4c(c23)CCCC4)CC1	https://dx.doi.org/10.1021/acsmedchemlett.2c00325
CHEMBL1542168	47072	None	8	Human	Binding	IC50	=	640.00	6.19	-	2	Antagonist activity at beta-galactosidase fragment-fused GRP55 (unknown origin) over-expressed with N-terminal deletion beta-galactosidase mutant-tagged beta-arr2 in human CHOK1 cells assessed as inhibition of LPI induced beta-arrestin activity preincubated for 30 mins by PathHunter chemiluminescent complementation assay	ChEMBL	423.1	4	0	5	4.05	O=C(N1CCC(n2nc(-c3ccccc3)oc2=O)CC1)C1(c2ccc(Cl)cc2)CC1	https://dx.doi.org/10.1016/j.bmcl.2016.02.030
CHEMBL1567371	49810	None	9	Human	Binding	IC50	=	500.00	6.30	-	1	Antagonist activity at GPR55 (unknown origin) by beta-arrestin recruitment assay	ChEMBL	527.2	6	2	7	5.57	Cc1cc(C)c2nc(-c3cccnc3)cc(C(=O)Nc3ccc(S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1	https://dx.doi.org/10.1021/acsmedchemlett.2c00325
CHEMBL1703772	59277	None	4	Human	Binding	IC50	=	12000.00	4.92	-	2	Antagonist activity at beta-galactosidase fragment-fused GRP55 (unknown origin) over-expressed with N-terminal deletion beta-galactosidase mutant-tagged beta-arr2 in human CHOK1 cells assessed as inhibition of LPI induced beta-arrestin activity preincubated for 30 mins by PathHunter chemiluminescent complementation assay	ChEMBL	389.2	4	0	5	3.40	O=C(N1CCC(n2nc(-c3ccccc3)oc2=O)CC1)C1(c2ccccc2)CC1	https://dx.doi.org/10.1016/j.bmcl.2016.02.030
CHEMBL2177249	82526	None	0	Human	Binding	IC50	=	3230.00	5.49	-	3	Antagonist activity at human GPR55 transfected in CHO cells assessed as inhibition of LPI-induced beta-arrestin recruitment incubated 60 mins prior to LPI addition by beta-arrestin translocation assay	ChEMBL	366.2	8	0	4	5.13	CCCCCc1cc(OC)c2cc(Cc3cccc(OC)c3)c(=O)oc2c1	https://dx.doi.org/10.1021/jm4005175
CHEMBL2177250	82527	None	0	Human	Binding	IC50	=	10600.00	4.97	-	3	Antagonist activity at human GPR55 transfected in CHO cells assessed as inhibition of LPI-induced beta-arrestin recruitment incubated 60 mins prior to LPI addition by beta-arrestin translocation assay	ChEMBL	338.2	6	2	4	4.53	CCCCCc1cc(O)c2cc(Cc3cccc(O)c3)c(=O)oc2c1	https://dx.doi.org/10.1021/jm4005175
CHEMBL2177253	82530	None	0	Human	Binding	IC50	=	5080.00	5.29	-	3	Antagonist activity at human GPR55 transfected in CHO cells assessed as inhibition of LPI-induced beta-arrestin recruitment incubated 60 mins prior to LPI addition by beta-arrestin translocation assay	ChEMBL	350.2	7	0	3	5.43	CCCCCc1cc(OC)c2cc(Cc3ccccc3C)c(=O)oc2c1	https://dx.doi.org/10.1021/jm4005175
CHEMBL2177257	82534	None	22	Human	Binding	IC50	=	6350.00	5.20	-	3	Antagonist activity at human GPR55 transfected in CHO cells assessed as inhibition of LPI-induced beta-arrestin recruitment incubated 60 mins prior to LPI addition by beta-arrestin translocation assay	ChEMBL	366.2	8	0	4	5.13	CCCCCc1cc(OC)c2cc(Cc3ccccc3OC)c(=O)oc2c1	https://dx.doi.org/10.1021/jm4005175
CHEMBL2177259	82536	None	0	Human	Binding	IC50	=	9000.00	5.05	-	3	Antagonist activity at human GPR55 transfected in CHO cells assessed as inhibition of LPI-induced beta-arrestin recruitment incubated 60 mins prior to LPI addition by beta-arrestin translocation assay	ChEMBL	370.1	7	0	3	5.78	CCCCCc1cc(OC)c2cc(Cc3ccccc3Cl)c(=O)oc2c1	https://dx.doi.org/10.1021/jm4005175
CHEMBL2177263	82540	None	0	Human	Binding	IC50	=	10000.00	5.00	-	3	Antagonist activity at human GPR55 transfected in CHO cells assessed as inhibition of LPI-induced beta-arrestin recruitment incubated 60 mins prior to LPI addition by beta-arrestin translocation assay	ChEMBL	392.2	9	0	3	6.64	CCCCCCC(C)(C)c1cc(OC)c2cc(Cc3ccccc3)c(=O)oc2c1	https://dx.doi.org/10.1021/jm4005175
CHEMBL2177264	82541	None	0	Human	Binding	IC50	=	358.00	6.45	-	4	Antagonist activity at human GPR55 transfected in CHO cells assessed as inhibition of LPI-induced beta-arrestin recruitment incubated 60 mins prior to LPI addition by beta-arrestin translocation assay	ChEMBL	378.2	8	1	3	6.34	CCCCCCC(C)(C)c1cc(O)c2cc(Cc3ccccc3)c(=O)oc2c1	https://dx.doi.org/10.1021/jm4005175
CHEMBL2181540	83067	None	0	Human	Binding	IC50	=	261.00	6.58	-	4	Antagonist activity at human GPR55 transfected in CHO cells assessed as inhibition of LPI-induced beta-arrestin recruitment incubated 60 mins prior to LPI addition by beta-arrestin translocation assay	ChEMBL	394.2	8	2	4	6.04	CCCCCCC(C)(C)c1cc(O)c2cc(Cc3ccccc3O)c(=O)oc2c1	https://dx.doi.org/10.1021/jm4005175

Showing 1 to 20 of 111 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)