GPCRdb

Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Δ¹²-PGJ₂	1361	None	0	Human	Binding	pKd	None	-	7.00	-15	3	Unclassified	Guide to Pharmacology	334.2	12	2	3	4.20	CCCCC[C@H](O)C/C=C1/C(=O)C=C[C@@H]1C/C=C\CCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/9579725
15-deoxy-Δ^12,14-PGJ₂	20	None	0	Human	Binding	pKi	None	-	6.60	-79	3	Unclassified	Guide to Pharmacology	316.2	11	1	2	5.01	CCCCC/C=C\C=C1\C(=O)C=C[C@@H]1C/C=C\CCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/9579725
AH-23848	218901	3H-PGD2	0	Human	Binding	pKi	=	1380.00	5.86	4	6	-	PDSP KiDatabase	477.3	11	1	5	5.08	O=C1CCC(CCC(=CCC(C(=O)O)N2CCOCC2)OCc2ccc(-c3ccccc3)cc2)C1	-
AH-23848	218901	3H-PGD2	0	Human	Binding	pKi	=	697.00	6.16	4	6	-	PDSP KiDatabase	477.3	11	1	5	5.08	O=C1CCC(CCC(=CCC(C(=O)O)N2CCOCC2)OCc2ccc(-c3ccccc3)cc2)C1	-
AH6809	320	None	49	Human	Binding	pKi	None	-	5.80	-4	10	Unclassified	Guide to Pharmacology	298.1	3	1	4	3.43	CC(C)Oc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1	https://pubmed.ncbi.nlm.nih.gov/10634944
AH6809	320	3H-PGD2	49	Human	Binding	pKi	=	1415.00	5.85	-4	10	-	PDSP KiDatabase	298.1	3	1	4	3.43	CC(C)Oc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1	-
asapiprant	493	None	42	Human	Binding	pKi	=	-	6.62	-	1	Displacement of [³H]-PGD₂ from DP receptor in human platelet membranes	Guide to Pharmacology	501.2	9	1	8	3.10	CC(C)Oc1ccc(S(=O)(=O)N2CCN(c3ccc(-c4ncco4)c(OCC(=O)O)c3)CC2)cc1	-
asapiprant	493	None	42	Human	Binding	Ki	=	240.00	6.62	-	1	Displacement of [3H]-PGD2 from PGD2 receptor in human platelet membranes after 2 hrs by micro beta scintillation counting analysis	ChEMBL	501.2	9	1	8	3.10	CC(C)Oc1ccc(S(=O)(=O)N2CCN(c3ccc(-c4ncco4)c(OCC(=O)O)c3)CC2)cc1	-
BI-671800	197807	None	33	Human	Binding	IC50	=	25600.00	4.59	-	3	Displacement of [3H]PGD2 from prostaglandin D1 receptor in human platelet membrane	ChEMBL	501.2	8	2	6	4.10	CN(C)c1nc(Cc2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cc2)nc(N(C)C)c1CC(=O)O	https://dx.doi.org/10.1016/j.bmcl.2009.06.085
BUTAPROST	97856	3H-PGD2	23	Human	Binding	pKi	=	10000.00	5.00	-91	9	-	PDSP KiDatabase	408.3	13	2	5	4.34	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	-
BUTAPROST	97856	3H-PGD2	23	Human	Binding	pKi	=	10000.00	5.00	-91	9	-	PDSP KiDatabase	408.3	13	2	5	4.34	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	-
butaprost (free acid form)	747	None	19	Human	Binding	pKi	None	-	4.90	-199	9	Unclassified	Guide to Pharmacology	394.3	13	3	4	4.25	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1	https://pubmed.ncbi.nlm.nih.gov/10634944
BW 245C	752	None	0	Human	Binding	pKi	=	-	8.90	22	9	Unclassified	Guide to Pharmacology	368.2	11	3	4	2.66	O=C(O)CCCCCCC1C(=O)NC(=O)N1CCC(O)C1CCCCC1	https://pubmed.ncbi.nlm.nih.gov/10448933
BW 245C	752	None	0	Human	Binding	pKi	=	-	8.90	22	9	Unclassified	Guide to Pharmacology	368.2	11	3	4	2.66	O=C(O)CCCCCCC1C(=O)NC(=O)N1CCC(O)C1CCCCC1	https://pubmed.ncbi.nlm.nih.gov/7642548
BW 245C	752	None	0	Human	Binding	pKi	=	-	8.90	22	9	Unclassified	Guide to Pharmacology	368.2	11	3	4	2.66	O=C(O)CCCCCCC1C(=O)NC(=O)N1CCC(O)C1CCCCC1	https://pubmed.ncbi.nlm.nih.gov/9579725
BW 245C	752	3H-PGD2	0	Human	Binding	pKi	=	0.40	9.40	22	9	-	PDSP KiDatabase	368.2	11	3	4	2.66	O=C(O)CCCCCCC1C(=O)NC(=O)N1CCC(O)C1CCCCC1	-
BW 245C	752	None	0	Rat	Binding	pKi	None	-	7.80	-22	9	Unclassified	Guide to Pharmacology	368.2	11	3	4	2.66	O=C(O)CCCCCCC1C(=O)NC(=O)N1CCC(O)C1CCCCC1	https://pubmed.ncbi.nlm.nih.gov/10448933
BW 245C	752	None	0	Mouse	Binding	pKi	None	-	6.60	-354	9	Unclassified	Guide to Pharmacology	368.2	11	3	4	2.66	O=C(O)CCCCCCC1C(=O)NC(=O)N1CCC(O)C1CCCCC1	https://pubmed.ncbi.nlm.nih.gov/9313928
BW 245C	752	3H-PGD2	0	Mouse	Binding	pKi	=	250.00	6.60	-354	9	-	PDSP KiDatabase	368.2	11	3	4	2.66	O=C(O)CCCCCCC1C(=O)NC(=O)N1CCC(O)C1CCCCC1	-
BWA868C	756	None	0	Human	Binding	pKi	=	-	8.95	151	4	Unclassified	Guide to Pharmacology	459.3	13	3	5	3.69	O=C(O)CCCCCCC1C(=O)N(Cc2ccccc2)C(=O)N1NCC(O)C1CCCCC1	https://pubmed.ncbi.nlm.nih.gov/7642548

Showing 1 to 20 of 698 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

AH6809	320	None	49	Human	Functional	Ki	=	1400.00	5.85	-	10	Antagonist activity at DP1 receptor (unknown origin) by functional cAMP assay	ChEMBL	298.1	3	1	4	3.43	CC(C)Oc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1	https://dx.doi.org/10.1021/jm401431x
asapiprant	493	None	42	Human	Functional	IC50	=	520.00	6.28	-	1	Antagonist activity at PGD2 receptor in human platelets assessed as inhibition of PGD2-mediated cAMP accumulation preincubated for 5 mins followed by PGD2 addition measured after 2 mins by HTRF assay	ChEMBL	501.2	9	1	8	3.10	CC(C)Oc1ccc(S(=O)(=O)N2CCN(c3ccc(-c4ncco4)c(OCC(=O)O)c3)CC2)cc1	-
CHEMBL116836	10521	None	0	Human	Functional	IC50	=	1.80	8.74	616	2	Inhibition of cAMP formation evoked by the prostaglandin D2 receptor in human platelets	ChEMBL	443.2	8	2	3	6.02	CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3csc4ccc(F)cc34)[C@@H]1C2	https://dx.doi.org/10.1021/jm970343g
CHEMBL116837	10522	None	23	Human	Functional	IC50	=	1.00	9.00	151	2	Inhibition of cAMP formation evoked by the prostaglandin D2 receptor in human platelets	ChEMBL	441.2	8	3	4	5.59	CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3csc4ccc(O)cc34)[C@@H]1C2	https://dx.doi.org/10.1021/jm970343g
CHEMBL117399	11015	None	0	Human	Functional	IC50	=	64.00	7.19	69	2	Inhibition of cAMP formation evoked by the prostaglandin D2 receptor in human platelets	ChEMBL	358.2	8	3	2	4.00	CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3ccc[nH]3)[C@@H]1C2	https://dx.doi.org/10.1021/jm970343g
CHEMBL119550	13794	None	0	Human	Functional	IC50	=	220.00	6.66	3	3	Inhibition of cAMP formation evoked by the prostaglandin D2 receptor in human platelets	ChEMBL	459.2	8	2	3	6.57	CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3ccc4oc5ccccc5c4c3)[C@@H]1C2	https://dx.doi.org/10.1021/jm970343g
CHEMBL119809	14146	None	0	Human	Functional	IC50	=	5.60	8.25	17	2	Inhibition of cAMP formation evoked by the prostaglandin D2 receptor in human platelets	ChEMBL	425.2	8	2	3	5.88	CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3cccc4ccsc34)[C@@H]1C2	https://dx.doi.org/10.1021/jm970343g
CHEMBL119810	14147	None	0	Human	Functional	IC50	=	2.80	8.55	213	2	Inhibition of cAMP formation evoked by the prostaglandin D2 receptor in human platelets	ChEMBL	441.2	8	3	4	5.59	CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3csc4cc(O)ccc34)[C@@H]1C2	https://dx.doi.org/10.1021/jm970343g
CHEMBL1287835	18987	None	0	Human	Functional	Ki	=	0.33	9.48	-	2	Antagonist activity at prostanoid DP1 receptor	ChEMBL	497.1	5	1	4	6.00	C[C@@H](c1ccc(Cl)c(Cl)c1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O	https://dx.doi.org/10.1016/j.bmcl.2010.10.018
CHEMBL1289084	19097	None	0	Human	Functional	Ki	=	12.00	7.92	-	1	Antagonist activity at prostanoid DP1 receptor	ChEMBL	463.1	5	1	4	5.34	CC(c1ccc(Cl)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCCC2CC(=O)O	https://dx.doi.org/10.1016/j.bmcl.2010.10.018
CHEMBL1289084	19097	None	0	Human	Functional	Ki	=	1.30	8.89	-	1	Antagonist activity at prostanoid DP1 receptor	ChEMBL	463.1	5	1	4	5.34	CC(c1ccc(Cl)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCCC2CC(=O)O	https://dx.doi.org/10.1016/j.bmcl.2010.10.018
CHEMBL1289984	19227	None	0	Human	Functional	Ki	=	0.89	9.05	-	2	Antagonist activity at prostanoid DP1 receptor	ChEMBL	449.1	5	1	4	4.78	CS(=O)(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)C(CC(=O)O)CCC3	https://dx.doi.org/10.1016/j.bmcl.2010.10.018
CHEMBL1290079	19241	None	0	Human	Functional	Ki	=	0.75	9.12	-	2	Antagonist activity at prostanoid DP1 receptor	ChEMBL	463.1	5	1	4	5.34	C[C@@H](c1ccc(Cl)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O	https://dx.doi.org/10.1016/j.bmcl.2010.10.018
CHEMBL1290080	19242	None	0	Human	Functional	Ki	=	0.38	9.42	-	2	Antagonist activity at prostanoid DP1 receptor	ChEMBL	481.1	5	1	4	5.48	C[C@@H](c1ccc(Cl)c(F)c1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O	https://dx.doi.org/10.1016/j.bmcl.2010.10.018
CHEMBL1290187	19257	None	0	Human	Functional	Ki	=	0.41	9.39	-	2	Antagonist activity at prostanoid DP1 receptor	ChEMBL	481.1	5	1	4	5.48	C[C@@H](c1ccc(Cl)cc1F)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O	https://dx.doi.org/10.1016/j.bmcl.2010.10.018
CHEMBL1290298	19274	None	0	Human	Functional	Ki	=	0.36	9.44	-	2	Antagonist activity at prostanoid DP1 receptor	ChEMBL	429.1	5	1	4	4.69	C[C@@H](c1ccccc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O	https://dx.doi.org/10.1016/j.bmcl.2010.10.018
CHEMBL1290299	19275	None	0	Human	Functional	Ki	=	0.31	9.51	-	2	Antagonist activity at prostanoid DP1 receptor	ChEMBL	463.1	5	1	4	5.34	C[C@@H](c1cccc(Cl)c1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O	https://dx.doi.org/10.1016/j.bmcl.2010.10.018
CHEMBL1290413	19298	None	0	Human	Functional	IC50	=	2.50	8.60	7762	8	Antagonist activity at prostanoid DP1 receptor in human platelet assessed as inhibition of PGD2 induced accumulation of cAMP	ChEMBL	497.1	5	1	4	5.71	C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O	https://dx.doi.org/10.1016/j.bmcl.2010.10.018
CHEMBL1290413	19298	None	0	Human	Functional	Ki	=	0.43	9.37	7762	8	Antagonist activity at prostanoid DP1 receptor	ChEMBL	497.1	5	1	4	5.71	C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O	https://dx.doi.org/10.1016/j.bmcl.2010.10.018
CHEMBL1290414	19299	None	0	Human	Functional	Ki	=	0.33	9.48	-	2	Antagonist activity at prostanoid DP1 receptor	ChEMBL	447.1	5	1	4	4.83	C[C@@H](c1ccc(F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O	https://dx.doi.org/10.1016/j.bmcl.2010.10.018

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Ligand source activities (1 row/activity)