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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

α-ergocryptine	358	None	18	Rat	Binding	Ki	=	7.94	8.10	-6	21	DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)	ChEMBL	575.3	5	3	6	2.43	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	-
α-ergocryptine	358	None	18	Rat	Binding	IC50	=	14.00	7.85	-6	21	DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)	ChEMBL	575.3	5	3	6	2.43	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	-
α-ergocryptine	358	None	18	Rat	Binding	pKi	=	8.10	8.09	-6	21	DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)	Drug Central	575.3	5	3	6	2.43	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	-
(±)-adrenaline	3139	None	60	Human	Binding	pKi	=	5.10	8.29	-43	14	None	Drug Central	183.1	3	4	4	0.35	CNCC(O)c1ccc(O)c(O)c1	-
(±)-adrenaline	3139	125I-HEAT	60	Human	Binding	pKi	=	9400.00	5.03	-43	14	-	PDSP KiDatabase	183.1	3	4	4	0.35	CNCC(O)c1ccc(O)c(O)c1	-
(+)-adrenaline	290	None	26	Human	Binding	pKi	=	-	5.10	-7	5	Unclassified	Guide to Pharmacology	183.1	3	4	4	0.35	CNC[C@@H](O)c1ccc(O)c(O)c1	https://pubmed.ncbi.nlm.nih.gov/7651358
(+)-chlorpheniramine	918	None	42	Rat	Binding	Ki	=	8613.00	5.07	-436	27	DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)	ChEMBL	274.1	5	0	2	3.82	CN(C)CC[C@@H](c1ccc(Cl)cc1)c1ccccn1	-
(+)-chlorpheniramine	918	None	42	Rat	Binding	IC50	=	15560.00	4.81	-436	27	DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)	ChEMBL	274.1	5	0	2	3.82	CN(C)CC[C@@H](c1ccc(Cl)cc1)c1ccccn1	-
(+)-chlorpheniramine	918	None	42	Rat	Binding	pKi	=	5.07	8.30	-436	27	DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)	Drug Central	274.1	5	0	2	3.82	CN(C)CC[C@@H](c1ccc(Cl)cc1)c1ccccn1	-
(+)-cyclazosin	1278	None	10	Human	Binding	pKi	=	-	9.30	2	9	Unclassified	Guide to Pharmacology	437.2	4	1	8	3.10	COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC	https://pubmed.ncbi.nlm.nih.gov/8917649
(+)-cyclazosin	1278	None	10	Human	Binding	pKi	=	-	9.30	2	9	Unclassified	Guide to Pharmacology	437.2	4	1	8	3.10	COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC	https://pubmed.ncbi.nlm.nih.gov/32608144
(+)-cyclazosin	1278	None	10	Human	Binding	Ki	=	0.20	9.70	2	9	Binding affinity was tested on cloned hamster Alpha-1B adrenergic receptor	ChEMBL	437.2	4	1	8	3.10	COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC	https://dx.doi.org/10.1021/jm960697s
(+)-cyclazosin	1278	None	10	Human	Binding	Ki	=	0.31	9.51	2	9	Compound was tested for binding affinity against cloned Alpha-1B adrenergic receptor from hamster smooth muscle using radioligand ([3H]prazosin) binding assay	ChEMBL	437.2	4	1	8	3.10	COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC	https://dx.doi.org/10.1021/jm960510x
(+)-cyclazosin	1278	None	10	Human	Binding	Ki	=	0.32	9.49	2	9	Displacement of [3H]prazosin from human Alpha-1B adrenoceptor expressed in CHO cells	ChEMBL	437.2	4	1	8	3.10	COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC	https://dx.doi.org/10.1021/jm8016046
(+)-CYCLAZOSIN	85391	None	0	Human	Binding	Ki	=	0.13	9.87	-1	5	Displacement of [3H]prazosin from Homo sapiens (human) alpha1B adrenergic receptor	ChEMBL	437.2	4	1	8	3.10	COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC	https://dx.doi.org/10.1007/s00044-004-0024-8
(+)-CYCLAZOSIN	85391	None	0	Human	Binding	Ki	=	0.69	9.16	-1	5	Binding affinity to alpha1B adrenoreceptor (unknown origin) by radioligand binding assay	ChEMBL	437.2	4	1	8	3.10	COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC	https://dx.doi.org/10.1007/s00044-004-0024-8
(+)-cyclazosin	1278	None	10	Human	Binding	Ki	=	0.69	9.16	2	9	Binding affinity to human alpha1B adrenergic receptor	ChEMBL	437.2	4	1	8	3.10	COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC	https://dx.doi.org/10.1016/j.bmc.2018.05.023
(+)-cyclazosin	1278	None	10	Human	Binding	Ki	=	0.13	9.87	2	9	Displacement of [3H]prazosin from human alpha1B adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method	ChEMBL	437.2	4	1	8	3.10	COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC	https://dx.doi.org/10.1016/j.bmc.2018.05.023
(+)-cyclazosin	1278	None	10	Human	Binding	Ki	=	0.13	9.87	2	9	Displacement of [3H]prazosin from human adrenergic alpha-1b receptor expressed in CHO cells	ChEMBL	437.2	4	1	8	3.10	COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC	https://dx.doi.org/10.1016/j.bmc.2007.01.028
(+)-CYCLAZOSIN	85391	None	0	Rat	Binding	Ki	=	0.21	9.68	1	5	Binding affinity to alpha1B adrenoreceptor in Rattus norvegicus (rat) liver	ChEMBL	437.2	4	1	8	3.10	COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC	https://dx.doi.org/10.1007/s00044-004-0024-8

Showing 1 to 20 of 2,501 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)