GPCRdb

Initializing potency table...

Ligand source activities (1 row/activity)

Affinity
Potency

Search:

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

5-(3-METHYL-1-TRIAZENO)IMIDAZOLE-4-CARBOXAMIDE	190457	None	0	Human	Binding	Ki	=	5.01	8.30	-	1	Binding affinity to NK3 receptor	ChEMBL	393.2	5	2	3	5.37	Nc1c(-c2ccccc2)nc2ccccc2c1C(=O)N[C@H](c1ccccc1)C1CC1	https://dx.doi.org/10.1016/j.bmcl.2008.12.005
[Phe(Me)⁷]neurokinin B	3094	None	0	Human	Binding	pKi	=	-	9.15	-1	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9190866
[Phe(Me)⁷]neurokinin B	3094	None	0	Human	Binding	pKi	=	-	9.15	-1	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/11226387
[Phe(Me)⁷]neurokinin B	3094	None	0	Mouse	Binding	pKi	None	-	9.20	1	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/11226387
A-85380	218616	3H-Eledoisin	0	Human	Binding	pKi	=	10000.00	5.00	-1	13	-	PDSP KiDatabase	164.1	3	1	3	0.82	c1cncc(OCC2CCN2)c1	-
ABT-594	219818	3H-SENKTIDE	0	Human	Binding	pKi	=	1000.00	6.00	-2	37	-	PDSP KiDatabase	198.1	3	1	3	1.48	Clc1ccc(OCC2CCN2)cn1	-
aprepitant	448	None	58	Human	Binding	pKi	=	6.34	8.20	-50	8	Displacement of [3H]osanetant from wild type human NK3 receptor expressed in HEK293 cells	Drug Central	534.1	6	2	5	4.95	C[C@@H](O[C@H]1OCCN(Cc2nc(=O)[nH][nH]2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1	-
aprepitant	448	None	58	Human	Binding	Ki	=	454.10	6.34	-50	8	Displacement of [3H]osanetant from wild type human NK3 receptor expressed in HEK293 cells	ChEMBL	534.1	6	2	5	4.95	C[C@@H](O[C@H]1OCCN(Cc2nc(=O)[nH][nH]2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1	https://dx.doi.org/10.1021/jm2017072
ATOMOXETINE	205585	UNDEFINED	33	Rat	Binding	pKi	=	1000.00	6.00	-1	37	-	PDSP KiDatabase	255.2	6	1	2	3.73	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	-
AZD-7624	210849	None	1	Human	Binding	Ki	=	18.00	7.75	13	2	Binding Affinity of [125I]-MePhe7-NKB towards Tachykinin receptor 3-CHO cell membranes(n=3-8)	ChEMBL	366.2	5	1	2	5.78	CC[C@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1	https://dx.doi.org/10.1021/jm9602423
BCTC	218979	125I-Eledoisin	0	Rat	Binding	pKi	=	10000.00	5.00	-10471285	17	-	PDSP KiDatabase	372.2	2	1	3	4.39	CC(C)(C)c1ccc(NC(=O)N2CCN(c3ncccc3Cl)CC2)cc1	-
BUFOKININ	212014	None	0	Human	Binding	IC50	=	2990.00	5.52	-	1	Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysis	ChEMBL	-	-	-	-	-	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(N)=O	https://dx.doi.org/10.1016/j.bmc.2013.01.036
CHEMBL10020	4207	None	0	Human	Binding	Ki	=	29.90	7.52	-	1	Binding affinity towards cloned human Tachykinin receptor 3 (hNK-3) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	400.1	5	1	2	6.44	CC[C@@H](NC(=O)c1c(Cl)c(-c2ccccc2)nc2ccccc12)c1ccccc1	https://dx.doi.org/10.1021/jm980633c
CHEMBL10031	4221	None	0	Human	Binding	Ki	=	129.00	6.89	-	1	Binding affinity towards cloned human Tachykinin receptor 3 (hNK-3) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	392.2	4	1	2	6.10	O=C(NC1(c2ccccc2)CCCC1)c1cc(-c2ccccc2)nc2ccccc12	https://dx.doi.org/10.1021/jm980633c
CHEMBL10039	4235	None	0	Human	Binding	Ki	=	1653.00	5.78	-	1	Binding affinity towards cloned human Tachykinin receptor 3 (hNK-3) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	382.1	5	2	3	4.46	O=C(N[C@H](C(=O)O)c1ccccc1)c1cc(-c2ccccc2)nc2ccccc12	https://dx.doi.org/10.1021/jm980633c
CHEMBL10079	4297	None	0	Human	Binding	Ki	=	840.00	6.08	2	2	Binding affinity towards cloned human Tachykinin receptor 3 (hNK-3) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	366.2	5	1	2	5.78	CC[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1	https://dx.doi.org/10.1021/jm980633c
CHEMBL10079	4297	None	0	Human	Binding	Ki	=	13.80	7.86	2	2	Binding affinity towards cloned human Tachykinin receptor 3 (hNK-3) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	366.2	5	1	2	5.78	CC[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1	https://dx.doi.org/10.1021/jm980633c
CHEMBL10134	4391	None	0	Human	Binding	Ki	=	7.10	8.15	-	1	Binding affinity towards cloned human Tachykinin receptor 3 (hNK-3) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	394.2	6	1	2	6.34	CCc1c(-c2ccccc2)nc2ccccc2c1C(=O)NC(CC)c1ccccc1	https://dx.doi.org/10.1021/jm980633c
CHEMBL10134	4391	None	0	Human	Binding	Ki	=	6.31	8.20	-	1	Displacement of [125I]-MePhe7-NKB from human NK3 receptor expressed in CHO cells after 90 mins by gamma counting	ChEMBL	394.2	6	1	2	6.34	CCc1c(-c2ccccc2)nc2ccccc2c1C(=O)NC(CC)c1ccccc1	https://dx.doi.org/10.1021/jm1010012
CHEMBL10134	4391	None	0	Human	Binding	Ki	=	6.31	8.20	-	1	Binding affinity to human NK3 receptor expressed in CHO cells	ChEMBL	394.2	6	1	2	6.34	CCc1c(-c2ccccc2)nc2ccccc2c1C(=O)NC(CC)c1ccccc1	https://dx.doi.org/10.1016/j.bmcl.2011.10.014

Showing 1 to 20 of 1,319 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)