Ligand source activities (1 row/activity)
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 1327 | 7284 | 0 | None | -6 | 2 | Human | 7.3 | pIC50 | None | 7.3 | Functional | Guide to Pharmacology | None | None | None | None | 11705773 | ||||
| 13339 | 7990 | 0 | None | -1 | 2 | Human | 9.5 | pKB | = | 9.5 | Functional | Guide to Pharmacology | 613 | 8 | 1 | 6 | 5.1 | CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6 | 38628803 | ||
| 146361282 | 7990 | 0 | None | -1 | 2 | Human | 9.5 | pKB | = | 9.5 | Functional | Guide to Pharmacology | 613 | 8 | 1 | 6 | 5.1 | CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6 | 38628803 | ||
| 13339 | 7990 | 0 | None | 1 | 2 | Rat | 9.6 | pKB | = | 9.6 | Functional | Guide to Pharmacology | 613 | 8 | 1 | 6 | 5.1 | CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6 | 38628803 | ||
| 146361282 | 7990 | 0 | None | 1 | 2 | Rat | 9.6 | pKB | = | 9.6 | Functional | Guide to Pharmacology | 613 | 8 | 1 | 6 | 5.1 | CCOC1=C(C=CC=C1)C2=CC=C(N3CCN(C[C@H]3CC)C(=O)C4(CCC4)C(F)(F)F)C(=N2)C(=O)N[C@@H]5CN6CCC5CC6 | 38628803 | ||
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 134611880 | 7066 | 0 | None | -2 | 5 | Mouse | 8.0 | pKd | = | 8.0 | Binding | Drug Central | None | None | None | None | None | ||||
| 16132265 | 7066 | 0 | None | -2 | 5 | Mouse | 8.0 | pKd | = | 8.0 | Binding | Drug Central | None | None | None | None | None | ||||
| 3633 | 7066 | 0 | None | -2 | 5 | Mouse | 8.0 | pKd | = | 8.0 | Binding | Drug Central | None | None | None | None | None | ||||
| 4931 | 7066 | 0 | None | -2 | 5 | Mouse | 8.0 | pKd | = | 8.0 | Binding | Drug Central | None | None | None | None | None | ||||
| CHEMBL1201610 | 7066 | 0 | None | -2 | 5 | Mouse | 8.0 | pKd | = | 8.0 | Binding | Drug Central | None | None | None | None | None | ||||
| DB01285 | 7066 | 0 | None | -2 | 5 | Mouse | 8.0 | pKd | = | 8.0 | Binding | Drug Central | None | None | None | None | None | ||||
| 1331 | 7065 | 0 | None | - | 1 | Mouse | 9.8 | pKd | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 8754753 | ||||
| 1332 | 7067 | 0 | None | - | 1 | Human | 9.0 | pKd | None | 9 | Binding | Guide to Pharmacology | None | None | None | None | 8754753 | ||||
| 3037130 | 7067 | 0 | None | - | 1 | Human | 9.0 | pKd | None | 9 | Binding | Guide to Pharmacology | None | None | None | None | 8754753 | ||||
| CHEMBL3274101 | 7067 | 0 | None | - | 1 | Human | 9.0 | pKd | None | 9 | Binding | Guide to Pharmacology | None | None | None | None | 8754753 | ||||
| 129627786 | 7068 | 32 | None | 10 | 2 | Mouse | 9.1 | pKd | None | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8754753 | ||||
| 1330 | 7068 | 32 | None | 10 | 2 | Mouse | 9.1 | pKd | None | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8754753 | ||||
| 16129617 | 7068 | 32 | None | 10 | 2 | Mouse | 9.1 | pKd | None | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8754753 | ||||
| 16129674 | 7068 | 32 | None | 10 | 2 | Mouse | 9.1 | pKd | None | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8754753 | ||||
| 16133751 | 7068 | 32 | None | 10 | 2 | Mouse | 9.1 | pKd | None | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8754753 | ||||
| 16133802 | 7068 | 32 | None | 10 | 2 | Mouse | 9.1 | pKd | None | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8754753 | ||||
| 16162116 | 7068 | 32 | None | 10 | 2 | Mouse | 9.1 | pKd | None | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8754753 | ||||
| 3767 | 7068 | 32 | None | 10 | 2 | Mouse | 9.1 | pKd | None | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8754753 | ||||
| 4516 | 7068 | 32 | None | 10 | 2 | Mouse | 9.1 | pKd | None | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8754753 | ||||
| 60210072 | 7068 | 32 | None | 10 | 2 | Mouse | 9.1 | pKd | None | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8754753 | ||||
| 6965 | 7068 | 32 | None | 10 | 2 | Mouse | 9.1 | pKd | None | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8754753 | ||||
| CHEMBL2103784 | 7068 | 32 | None | 10 | 2 | Mouse | 9.1 | pKd | None | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8754753 | ||||
| DB01284 | 7068 | 32 | None | 10 | 2 | Mouse | 9.1 | pKd | None | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8754753 | ||||
| None | 224520 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 4538 | 145 | 63 | 61 | -15.2 | CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O | None | ||
| 129627786 | 7068 | 32 | None | -10 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | None | None | None | None | None | ||||
| 1330 | 7068 | 32 | None | -10 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | None | None | None | None | None | ||||
| 16129617 | 7068 | 32 | None | -10 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | None | None | None | None | None | ||||
| 16129674 | 7068 | 32 | None | -10 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | None | None | None | None | None | ||||
| 16133751 | 7068 | 32 | None | -10 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | None | None | None | None | None | ||||
| 16133802 | 7068 | 32 | None | -10 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | None | None | None | None | None | ||||
| 16162116 | 7068 | 32 | None | -10 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | None | None | None | None | None | ||||
| 3767 | 7068 | 32 | None | -10 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | None | None | None | None | None | ||||
| 4516 | 7068 | 32 | None | -10 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | None | None | None | None | None | ||||
| 60210072 | 7068 | 32 | None | -10 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | None | None | None | None | None | ||||
| 6965 | 7068 | 32 | None | -10 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | None | None | None | None | None | ||||
| CHEMBL2103784 | 7068 | 32 | None | -10 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | None | None | None | None | None | ||||
| DB01284 | 7068 | 32 | None | -10 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | None | None | None | None | None | ||||