GPCRdb

Initializing potency table...

Ligand source activities (1 row/activity)

Affinity
Potency

Search:

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

ABT-594	219818	3H-NPC 17731	0	Human	Binding	pKi	=	1000.00	6.00	-2	37	-	PDSP KiDatabase	198.1	3	1	3	1.48	Clc1ccc(OCC2CCN2)cn1	-
alprenolol	370	None	37	Human	Binding	AC50	=	14000.10	4.85	-	16	Binding affinity towards human BDKRB2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	249.2	8	2	3	2.15	C=CCc1ccccc1OCC(O)CNC(C)C	https://dx.doi.org/10.1038/s41467-023-40064-9
amiodarone	398	None	47	Human	Binding	pKi	=	5.12	8.29	-5	40	DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin)	Drug Central	645.0	11	0	4	6.94	CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1	-
amiodarone	398	None	47	Human	Binding	IC50	=	12966.00	4.89	-5	40	DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin)	ChEMBL	645.0	11	0	4	6.94	CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1	-
amiodarone	398	None	47	Human	Binding	Ki	=	7674.00	5.12	-5	40	DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin)	ChEMBL	645.0	11	0	4	6.94	CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1	-
AMSACRINE	167616	None	49	Human	Binding	AC50	=	8900.00	5.05	-	15	Binding affinity towards human BDKRB2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	393.1	5	2	5	4.51	COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12	https://dx.doi.org/10.1038/s41467-023-40064-9
anatibant	414	None	0	Human	Binding	pKi	=	-	8.20	2	2	Unclassified	Guide to Pharmacology	710.2	12	4	7	5.11	Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)N4CCC[C@H]4C(=O)NCCCNC(=O)c4ccc(C(=N)N)cc4)c3Cl)c2n1	https://pubmed.ncbi.nlm.nih.gov/10596852
anatibant	414	None	0	Rat	Binding	pKi	None	-	7.80	-2	2	Unclassified	Guide to Pharmacology	710.2	12	4	7	5.11	Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)N4CCC[C@H]4C(=O)NCCCNC(=O)c4ccc(C(=N)N)cc4)c3Cl)c2n1	https://pubmed.ncbi.nlm.nih.gov/10596852
B-9430	565	None	0	Human	Binding	pKi	None	-	9.10	1	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9276157
B-9430	565	None	0	Human	Binding	pKi	None	-	9.10	1	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8856115
B-9430	565	None	0	Mouse	Binding	pKi	None	-	9.00	-1	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9276157
BCTC	218979	3H-BRADYKININ	0	Rat	Binding	pKi	=	10000.00	5.00	-10471285	17	-	PDSP KiDatabase	372.2	2	1	3	4.39	CC(C)(C)c1ccc(NC(=O)N2CCN(c3ncccc3Cl)CC2)cc1	-
BENZETHONIUM	11852	None	18	Human	Binding	AC50	=	29999.90	4.52	-	35	Binding affinity towards human BDKRB2 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	412.3	11	0	2	6.07	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	https://dx.doi.org/10.1038/s41467-023-40064-9
bradykinin	717	None	37	Human	Binding	IC50	=	1.80	8.74	1	7	Displacement of [3H]Bradykinin from human recombinant bradykinin B2 receptor expressed in CHEM1 cells after 60 mins	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1016/j.bmcl.2013.01.025
bradykinin	717	None	37	Human	Binding	Ki	=	1.10	8.96	1	7	Displacement of [3H]Bradykinin from human recombinant bradykinin B2 receptor expressed in CHEM1 cells after 60 mins	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1016/j.bmcl.2013.01.025
bradykinin	717	None	37	Human	Binding	Ki	=	0.11	9.96	1	7	Ability to bind to human cloned B2 receptor in competition binding experiments with [3H]- bradykinin	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm990961s
bradykinin	717	None	37	Human	Binding	Ki	=	0.68	9.17	1	7	Binding affinity towards Bradykinin receptor B2 in human S34 clone cells	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm950716i
bradykinin	717	None	37	Human	Binding	Ki	=	0.07	10.19	1	7	Binding affinity towards human cloned Bradykinin receptor B2 expressed in CHO cells by [3H]bradykinin displacement.	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm9901531
bradykinin	717	None	37	Human	Binding	Ki	=	0.65	9.19	1	7	Binding affinity against human cloned Bradykinin receptor B2 expressed in CHO cells using [3H]-bradykinin as radioligand	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm9901529
bradykinin	717	None	37	Mouse	Binding	pKd	=	-	9.40	-1	7	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9333122

Showing 1 to 20 of 1,006 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)