Ligand source activities (1 row/activity)
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| CHEMBL1627325 | 215590 | 0 | None | 1 | 8 | Human | 10.5 | pEC50 | = | 10.5 | Functional | ChEMBL | None | None | None | CSCC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(C)(C)C)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O)[C@@H](C)O | 10.1021/jm900604g | ||||
| 3812 | 7504 | 42 | None | -1 | 3 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm900604g | ||||
| 439201 | 7504 | 42 | None | -1 | 3 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm900604g | ||||
| 649 | 7504 | 42 | None | -1 | 3 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm900604g | ||||
| CHEMBL406291 | 7504 | 42 | None | -1 | 3 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm900604g | ||||
| DB12126 | 7504 | 42 | None | -1 | 3 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm900604g | ||||
| 9851817 | 16453 | 0 | None | - | 1 | Guinea pig | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 607 | 8 | 1 | 5 | 7.3 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(F)(F)F)cc4)c3Cl)cccc2s1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL112991 | 16453 | 0 | None | - | 1 | Guinea pig | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 607 | 8 | 1 | 5 | 7.3 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(F)(F)F)cc4)c3Cl)cccc2s1 | 10.1016/s0960-894x(98)00736-7 | ||
| 44340964 | 16479 | 0 | None | - | 1 | Guinea pig | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 609 | 10 | 1 | 6 | 6.7 | COc1c(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)ccc(SC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113176 | 16479 | 0 | None | - | 1 | Guinea pig | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 609 | 10 | 1 | 6 | 6.7 | COc1c(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)ccc(SC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| 44341039 | 16283 | 0 | None | - | 1 | Guinea pig | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 597 | 9 | 1 | 5 | 6.6 | COc1ccc(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)c(Cl)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL112140 | 16283 | 0 | None | - | 1 | Guinea pig | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 597 | 9 | 1 | 5 | 6.6 | COc1ccc(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)c(Cl)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| 44340818 | 117386 | 0 | None | - | 1 | Guinea pig | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 539 | 8 | 1 | 5 | 6.3 | Cc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4scnc34)c2Cl)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL325624 | 117386 | 0 | None | - | 1 | Guinea pig | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 539 | 8 | 1 | 5 | 6.3 | Cc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4scnc34)c2Cl)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| 18941161 | 16501 | 0 | None | - | 1 | Guinea pig | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | 615 | 9 | 1 | 5 | 8.0 | Cc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4sc(-c5ccccc5)nc34)c2Cl)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113320 | 16501 | 0 | None | - | 1 | Guinea pig | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | 615 | 9 | 1 | 5 | 8.0 | Cc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4sc(-c5ccccc5)nc34)c2Cl)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| 44341214 | 117207 | 0 | None | - | 1 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 621 | 12 | 1 | 6 | 6.7 | CCCOc1c(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)ccc(OC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL324575 | 117207 | 0 | None | - | 1 | Guinea pig | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 621 | 12 | 1 | 6 | 6.7 | CCCOc1c(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)ccc(OC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| 18941160 | 16687 | 0 | None | - | 1 | Guinea pig | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 553 | 8 | 1 | 5 | 6.6 | Cc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4sc(C)nc34)c2Cl)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL114401 | 16687 | 0 | None | - | 1 | Guinea pig | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 553 | 8 | 1 | 5 | 6.6 | Cc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4sc(C)nc34)c2Cl)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| 44214279 | 16488 | 0 | None | - | 1 | Guinea pig | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 489 | 8 | 1 | 5 | 5.3 | C=C/C=C/C(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccc3sc(C)nc23)c1Cl | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113222 | 16488 | 0 | None | - | 1 | Guinea pig | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 489 | 8 | 1 | 5 | 5.3 | C=C/C=C/C(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccc3sc(C)nc23)c1Cl | 10.1016/s0960-894x(98)00736-7 | ||
| 10895913 | 16641 | 0 | None | - | 1 | Guinea pig | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 465 | 7 | 2 | 5 | 3.9 | CCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1C#N | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL114180 | 16641 | 0 | None | - | 1 | Guinea pig | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 465 | 7 | 2 | 5 | 3.9 | CCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1C#N | 10.1016/s0960-894x(98)00736-7 | ||
| 9831859 | 16478 | 0 | None | - | 1 | Guinea pig | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 508 | 10 | 3 | 6 | 3.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCCCCN)c3C#N)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113169 | 16478 | 0 | None | - | 1 | Guinea pig | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 508 | 10 | 3 | 6 | 3.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCCCCN)c3C#N)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| 10257108 | 16603 | 1 | None | - | 1 | Guinea pig | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 554 | 9 | 1 | 6 | 5.4 | COc1cccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2C#N)c1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113963 | 16603 | 1 | None | - | 1 | Guinea pig | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 554 | 9 | 1 | 6 | 5.4 | COc1cccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2C#N)c1 | 10.1016/s0960-894x(98)00736-7 | ||
| 44340760 | 117285 | 0 | None | - | 1 | Guinea pig | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 523 | 10 | 3 | 6 | 3.8 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCCCC(=O)O)c3C#N)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL324950 | 117285 | 0 | None | - | 1 | Guinea pig | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 523 | 10 | 3 | 6 | 3.8 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCCCC(=O)O)c3C#N)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| 22008916 | 16534 | 0 | None | - | 1 | Guinea pig | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 461 | 8 | 2 | 6 | 3.3 | CCNC(=O)NCC(=O)N(C)c1ccc(OC)c(COc2cccc3ccc(C)nc23)c1C#N | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113502 | 16534 | 0 | None | - | 1 | Guinea pig | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 461 | 8 | 2 | 6 | 3.3 | CCNC(=O)NCC(=O)N(C)c1ccc(OC)c(COc2cccc3ccc(C)nc23)c1C#N | 10.1016/s0960-894x(98)00736-7 | ||
| 44214619 | 117382 | 0 | None | - | 1 | Guinea pig | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 553 | 13 | 1 | 8 | 4.7 | COC(=O)CCCCC(=O)NCC(=O)N(C)c1ccc(OC)c(COc2cccc3ccc(C)nc23)c1SC | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL325601 | 117382 | 0 | None | - | 1 | Guinea pig | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 553 | 13 | 1 | 8 | 4.7 | COC(=O)CCCCC(=O)NCC(=O)N(C)c1ccc(OC)c(COc2cccc3ccc(C)nc23)c1SC | 10.1016/s0960-894x(98)00736-7 | ||
| 18941145 | 16735 | 0 | None | - | 1 | Guinea pig | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 569 | 9 | 1 | 6 | 6.3 | COc1cccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4sc(C)nc34)c2Cl)c1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL114732 | 16735 | 0 | None | - | 1 | Guinea pig | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 569 | 9 | 1 | 6 | 6.3 | COc1cccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4sc(C)nc34)c2Cl)c1 | 10.1016/s0960-894x(98)00736-7 | ||
| 22008929 | 16522 | 0 | None | - | 1 | Guinea pig | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 597 | 9 | 1 | 5 | 6.6 | COc1c(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)ccc(Cl)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113465 | 16522 | 0 | None | - | 1 | Guinea pig | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 597 | 9 | 1 | 5 | 6.6 | COc1c(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)ccc(Cl)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| 22008895 | 117335 | 0 | None | - | 1 | Guinea pig | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 592 | 8 | 1 | 5 | 6.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(F)(F)F)cc4)c3C#N)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL325255 | 117335 | 0 | None | - | 1 | Guinea pig | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 592 | 8 | 1 | 5 | 6.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(F)(F)F)cc4)c3C#N)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| 44340859 | 16815 | 0 | None | - | 1 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 599 | 11 | 2 | 8 | 5.0 | COc1ccc(N(C)C(=O)CNC(=O)/C=C/c2ccc(NC(C)=O)nc2)c(SC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL115163 | 16815 | 0 | None | - | 1 | Guinea pig | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 599 | 11 | 2 | 8 | 5.0 | COc1ccc(N(C)C(=O)CNC(=O)/C=C/c2ccc(NC(C)=O)nc2)c(SC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| 44340951 | 16774 | 0 | None | - | 1 | Guinea pig | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 587 | 11 | 1 | 7 | 6.4 | COc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(SC)c(COc3cccc4ccc(C)nc34)c2SC)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL114915 | 16774 | 0 | None | - | 1 | Guinea pig | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 587 | 11 | 1 | 7 | 6.4 | COc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(SC)c(COc3cccc4ccc(C)nc34)c2SC)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| 3812 | 7504 | 42 | None | -1 | 3 | Human | 8.8 | pED50 | = | 8.8 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00144a008 | ||||
| 439201 | 7504 | 42 | None | -1 | 3 | Human | 8.8 | pED50 | = | 8.8 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00144a008 | ||||
| 649 | 7504 | 42 | None | -1 | 3 | Human | 8.8 | pED50 | = | 8.8 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00144a008 | ||||
| CHEMBL406291 | 7504 | 42 | None | -1 | 3 | Human | 8.8 | pED50 | = | 8.8 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00144a008 | ||||
| DB12126 | 7504 | 42 | None | -1 | 3 | Human | 8.8 | pED50 | = | 8.8 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00144a008 | ||||
| CHEMBL2372138 | 216968 | 0 | None | - | 1 | Human | 8.0 | pED50 | = | 8 | Functional | ChEMBL | None | None | None | [N-]=[N+]=Nc1ccc(C[C@H](NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)cc1 | 10.1021/jm00144a008 | ||||
| CHEMBL2372165 | 216972 | 0 | None | - | 1 | Human | 7.7 | pED50 | = | 7.7 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)O | 10.1021/jm00144a008 | ||||
| CHEMBL2372173 | 216975 | 0 | None | - | 1 | Human | 7.6 | pED50 | = | 7.6 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)O | 10.1021/jm00144a008 | ||||
| CHEMBL2372157 | 216970 | 0 | None | - | 1 | Human | 7.6 | pED50 | = | 7.6 | Functional | ChEMBL | None | None | None | N#[N+]c1ccc(C[C@H](NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)cc1 | 10.1021/jm00144a008 | ||||
| CHEMBL2372164 | 216971 | 0 | None | - | 1 | Human | 7.6 | pED50 | = | 7.6 | Functional | ChEMBL | None | None | None | N#[N+]c1ccc(C[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)cc1 | 10.1021/jm00144a008 | ||||
| CHEMBL2372172 | 216974 | 0 | None | - | 1 | Human | 7.2 | pED50 | = | 7.2 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)O | 10.1021/jm00144a008 | ||||
| CHEMBL2372156 | 216969 | 0 | None | - | 1 | Human | 8.2 | pED50 | = | 8.2 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)O | 10.1021/jm00144a008 | ||||
| CHEMBL2372168 | 216973 | 0 | None | - | 1 | Human | 8.2 | pED50 | = | 8.2 | Functional | ChEMBL | None | None | None | [N-]=[N+]=Nc1ccc(C[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)cc1 | 10.1021/jm00144a008 | ||||
| 44191040 | 202763 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 519 | 6 | 0 | 7 | 5.5 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(C)ccnc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL559825 | 202763 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 519 | 6 | 0 | 7 | 5.5 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(C)ccnc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | 10.1021/jm9002445 | ||
| 667 | 8754 | 37 | None | 2 | 2 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00015a001 | ||||
| 6918173 | 8754 | 37 | None | 2 | 2 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00015a001 | ||||
| 71364 | 8754 | 37 | None | 2 | 2 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00015a001 | ||||
| CHEMBL2028850 | 8754 | 37 | None | 2 | 2 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00015a001 | ||||
| DB06196 | 8754 | 37 | None | 2 | 2 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00015a001 | ||||
| 25019714 | 203362 | 2 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 519 | 6 | 1 | 6 | 5.8 | Cc1cc(-c2[nH]ncc2C)c2cccc(OCc3c(C)ccnc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL563956 | 203362 | 2 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 519 | 6 | 1 | 6 | 5.8 | Cc1cc(-c2[nH]ncc2C)c2cccc(OCc3c(C)ccnc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | 10.1021/jm9002445 | ||
| 45272156 | 201838 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 556 | 6 | 0 | 7 | 6.8 | Cc1cc(-c2ncsc2Cl)c2cccc(OCc3c(C)ccnc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL549534 | 201838 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 556 | 6 | 0 | 7 | 6.8 | Cc1cc(-c2ncsc2Cl)c2cccc(OCc3c(C)ccnc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | 10.1021/jm9002445 | ||
| 44190944 | 202712 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 539 | 6 | 0 | 7 | 5.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL559436 | 202712 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 539 | 6 | 0 | 7 | 5.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | 10.1021/jm9002445 | ||
| 44190263 | 202733 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 483 | 7 | 1 | 6 | 5.4 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(C)ccnc3CNC(=O)C3CCCCC3)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL559565 | 202733 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 483 | 7 | 1 | 6 | 5.4 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(C)ccnc3CNC(=O)C3CCCCC3)c2n1 | 10.1021/jm9002445 | ||
| 10327403 | 85360 | 0 | None | 1 | 2 | Rat | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 702 | 14 | 4 | 10 | 3.8 | CN(C)CCCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL2112220 | 85360 | 0 | None | 1 | 2 | Rat | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 702 | 14 | 4 | 10 | 3.8 | CN(C)CCCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 9987299 | 85376 | 0 | None | 2 | 2 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 706 | 14 | 4 | 9 | 3.3 | CN(C)CCCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL2112283 | 85376 | 0 | None | 2 | 2 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 706 | 14 | 4 | 9 | 3.3 | CN(C)CCCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 44190941 | 202210 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 471 | 7 | 1 | 7 | 3.6 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CNS(C)(=O)=O)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL552296 | 202210 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 471 | 7 | 1 | 7 | 3.6 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CNS(C)(=O)=O)c2n1 | 10.1021/jm9002445 | ||
| 10327403 | 85360 | 0 | None | -1 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 702 | 14 | 4 | 10 | 3.8 | CN(C)CCCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL2112220 | 85360 | 0 | None | -1 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 702 | 14 | 4 | 10 | 3.8 | CN(C)CCCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 44190852 | 202185 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 465 | 6 | 0 | 7 | 4.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3COC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL552090 | 202185 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 465 | 6 | 0 | 7 | 4.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3COC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| 44191220 | 201809 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 398 | 4 | 0 | 5 | 5.3 | Cc1cc(-n2ccnc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL549337 | 201809 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 398 | 4 | 0 | 5 | 5.3 | Cc1cc(-n2ccnc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL2370243 | 216591 | 0 | None | - | 1 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@@H]1C2CCCCC2CN1C(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](CO)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)c1ccc(CN2CCCNCCNCCCNCC2)cc1)c1cccs1)C(=O)O | 10.1021/jm00015a001 | ||||
| 10327403 | 85360 | 0 | None | 1 | 2 | Rat | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 702 | 14 | 4 | 10 | 3.8 | CN(C)CCCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL2112220 | 85360 | 0 | None | 1 | 2 | Rat | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 702 | 14 | 4 | 10 | 3.8 | CN(C)CCCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 44190672 | 202123 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 364 | 4 | 0 | 5 | 4.6 | Cc1cc(-c2ccnn2C)c2cccc(OCc3ccncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL551757 | 202123 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 364 | 4 | 0 | 5 | 4.6 | Cc1cc(-c2ccnn2C)c2cccc(OCc3ccncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 9987299 | 85376 | 0 | None | -2 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 706 | 14 | 4 | 9 | 3.3 | CN(C)CCCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL2112283 | 85376 | 0 | None | -2 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 706 | 14 | 4 | 9 | 3.3 | CN(C)CCCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 44189787 | 203123 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 398 | 4 | 0 | 5 | 5.2 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL562434 | 203123 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 398 | 4 | 0 | 5 | 5.2 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44190853 | 203068 | 4 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 435 | 7 | 1 | 6 | 4.0 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CCC(N)=O)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL562097 | 203068 | 4 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 435 | 7 | 1 | 6 | 4.0 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CCC(N)=O)c2n1 | 10.1021/jm9002445 | ||
| 44190850 | 202002 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 463 | 7 | 1 | 6 | 4.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CNC(=O)C(C)C)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL550827 | 202002 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 463 | 7 | 1 | 6 | 4.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CNC(=O)C(C)C)c2n1 | 10.1021/jm9002445 | ||
| 9987299 | 85376 | 0 | None | 2 | 2 | Rat | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 706 | 14 | 4 | 9 | 3.3 | CN(C)CCCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL2112283 | 85376 | 0 | None | 2 | 2 | Rat | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 706 | 14 | 4 | 9 | 3.3 | CN(C)CCCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 44190851 | 203349 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 464 | 6 | 1 | 6 | 4.3 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CNC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL563878 | 203349 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 464 | 6 | 1 | 6 | 4.3 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CNC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| 44190854 | 202224 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 435 | 6 | 1 | 6 | 4.2 | CC(=O)NCc1cncc(Cl)c1COc1cccc2c(-c3ccnn3C)cc(C)nc12 | 10.1021/jm9002445 | ||
| CHEMBL552384 | 202224 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 435 | 6 | 1 | 6 | 4.2 | CC(=O)NCc1cncc(Cl)c1COc1cccc2c(-c3ccnn3C)cc(C)nc12 | 10.1021/jm9002445 | ||
| 44190753 | 203482 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 481 | 7 | 0 | 7 | 4.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3SCC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL564841 | 203482 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 481 | 7 | 0 | 7 | 4.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3SCC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| 44190077 | 203249 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 399 | 4 | 0 | 6 | 4.6 | Cc1cc(-c2ncnn2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL563254 | 203249 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 399 | 4 | 0 | 6 | 4.6 | Cc1cc(-c2ncnn2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44190266 | 202235 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 435 | 4 | 0 | 5 | 6.6 | Cc1cc(-c2scnc2Cl)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL552442 | 202235 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 435 | 4 | 0 | 5 | 6.6 | Cc1cc(-c2scnc2Cl)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44191138 | 202695 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 384 | 4 | 0 | 5 | 5.0 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL559273 | 202695 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 384 | 4 | 0 | 5 | 5.0 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44190943 | 202732 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 471 | 7 | 0 | 7 | 5.5 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3COc3ccccn3)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL559564 | 202732 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 471 | 7 | 0 | 7 | 5.5 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3COc3ccccn3)c2n1 | 10.1021/jm9002445 | ||
| 45267862 | 203099 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 434 | 5 | 0 | 7 | 4.3 | CC(=O)OCc1cncc(Cl)c1C(=O)c1cccc2c(-c3ccnn3C)cc(C)nc12 | 10.1021/jm9002445 | ||
| CHEMBL562296 | 203099 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 434 | 5 | 0 | 7 | 4.3 | CC(=O)OCc1cncc(Cl)c1C(=O)c1cccc2c(-c3ccnn3C)cc(C)nc12 | 10.1021/jm9002445 | ||
| 44190751 | 202124 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 479 | 6 | 0 | 8 | 6.2 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Sc3nccs3)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL551758 | 202124 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 479 | 6 | 0 | 8 | 6.2 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Sc3nccs3)c2n1 | 10.1021/jm9002445 | ||
| 44190942 | 203006 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 471 | 6 | 0 | 7 | 4.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Cn3ccccc3=O)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL561634 | 203006 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 471 | 6 | 0 | 7 | 4.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Cn3ccccc3=O)c2n1 | 10.1021/jm9002445 | ||
| 44190581 | 202723 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 443 | 7 | 1 | 6 | 4.5 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(C)ccnc3CNC(=O)C(C)C)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL559506 | 202723 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 443 | 7 | 1 | 6 | 4.5 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(C)ccnc3CNC(=O)C(C)C)c2n1 | 10.1021/jm9002445 | ||
| 44190267 | 201915 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 401 | 4 | 0 | 5 | 5.9 | Cc1cc(-c2cscn2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL550143 | 201915 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 401 | 4 | 0 | 5 | 5.9 | Cc1cc(-c2cscn2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44190168 | 201897 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 415 | 4 | 0 | 5 | 6.3 | Cc1cc(-c2csnc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL550016 | 201897 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 415 | 4 | 0 | 5 | 6.3 | Cc1cc(-c2csnc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44191224 | 203040 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 412 | 4 | 0 | 5 | 5.5 | Cc1cc(-c2ncc(C)n2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL561839 | 203040 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 412 | 4 | 0 | 5 | 5.5 | Cc1cc(-c2ncc(C)n2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44191226 | 202081 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 384 | 4 | 1 | 4 | 5.2 | Cc1cc(-c2ccn[nH]2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL551435 | 202081 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 384 | 4 | 1 | 4 | 5.2 | Cc1cc(-c2ccn[nH]2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44190361 | 201582 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 399 | 4 | 0 | 5 | 5.8 | Cc1cc(-c2conc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL538865 | 201582 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 399 | 4 | 0 | 5 | 5.8 | Cc1cc(-c2conc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44189789 | 202932 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 398 | 4 | 1 | 4 | 5.5 | Cc1cc(-c2n[nH]cc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL561223 | 202932 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 398 | 4 | 1 | 4 | 5.5 | Cc1cc(-c2n[nH]cc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44190167 | 203268 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 415 | 4 | 0 | 5 | 6.3 | Cc1cc(-c2ncsc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL563391 | 203268 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 415 | 4 | 0 | 5 | 6.3 | Cc1cc(-c2ncsc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44189792 | 201914 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 401 | 4 | 0 | 5 | 5.9 | Cc1cc(-c2cncs2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL550142 | 201914 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 401 | 4 | 0 | 5 | 5.9 | Cc1cc(-c2cncs2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44190752 | 202125 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 476 | 6 | 0 | 8 | 5.5 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Sc3nccn3C)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL551759 | 202125 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 476 | 6 | 0 | 8 | 5.5 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Sc3nccn3C)c2n1 | 10.1021/jm9002445 | ||
| 44190165 | 202742 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 401 | 4 | 0 | 5 | 5.9 | Cc1cc(-c2nccs2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL559645 | 202742 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 401 | 4 | 0 | 5 | 5.9 | Cc1cc(-c2nccs2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 667 | 8754 | 37 | None | 2 | 2 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00015a001 | ||||
| 6918173 | 8754 | 37 | None | 2 | 2 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00015a001 | ||||
| 71364 | 8754 | 37 | None | 2 | 2 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00015a001 | ||||
| CHEMBL2028850 | 8754 | 37 | None | 2 | 2 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00015a001 | ||||
| DB06196 | 8754 | 37 | None | 2 | 2 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | None | None | None | None | 10.1021/jm00015a001 | ||||
| 10327403 | 85360 | 0 | None | -1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 702 | 14 | 4 | 10 | 3.8 | CN(C)CCCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL2112220 | 85360 | 0 | None | -1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 702 | 14 | 4 | 10 | 3.8 | CN(C)CCCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 44189790 | 203421 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 398 | 4 | 1 | 4 | 5.5 | Cc1cc(-c2cn[nH]c2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL564341 | 203421 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 398 | 4 | 1 | 4 | 5.5 | Cc1cc(-c2cn[nH]c2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44190166 | 203413 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 415 | 4 | 0 | 5 | 6.3 | Cc1cc(-c2scnc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL564294 | 203413 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 415 | 4 | 0 | 5 | 6.3 | Cc1cc(-c2scnc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44190269 | 202975 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 415 | 4 | 0 | 5 | 6.3 | Cc1cc(-c2nscc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL561415 | 202975 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 415 | 4 | 0 | 5 | 6.3 | Cc1cc(-c2nscc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44190756 | 202216 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 463 | 7 | 0 | 6 | 4.6 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CCC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL552359 | 202216 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 463 | 7 | 0 | 6 | 4.6 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CCC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| 44190268 | 203290 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 435 | 4 | 0 | 5 | 6.6 | Cc1cc(-c2ncsc2Cl)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL563516 | 203290 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 435 | 4 | 0 | 5 | 6.6 | Cc1cc(-c2ncsc2Cl)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44190754 | 203227 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 497 | 7 | 0 | 7 | 3.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3[S+]([O-])CC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL563068 | 203227 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 497 | 7 | 0 | 7 | 3.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3[S+]([O-])CC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| 44191223 | 203046 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 398 | 4 | 0 | 5 | 5.2 | Cc1cc(-c2nccn2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL561899 | 203046 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 398 | 4 | 0 | 5 | 5.2 | Cc1cc(-c2nccn2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL2370243 | 216591 | 0 | None | - | 1 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@@H]1C2CCCCC2CN1C(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](CO)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)c1ccc(CN2CCCNCCNCCCNCC2)cc1)c1cccs1)C(=O)O | 10.1021/jm00015a001 | ||||
| 9987299 | 85376 | 0 | None | -2 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 706 | 14 | 4 | 9 | 3.3 | CN(C)CCCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL2112283 | 85376 | 0 | None | -2 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 706 | 14 | 4 | 9 | 3.3 | CN(C)CCCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 44190755 | 202606 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 465 | 7 | 0 | 7 | 4.0 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3OCC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL558279 | 202606 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 465 | 7 | 0 | 7 | 4.0 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3OCC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| 44191225 | 203175 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 384 | 4 | 0 | 5 | 5.0 | Cc1cc(-n2cccn2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL562747 | 203175 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 384 | 4 | 0 | 5 | 5.0 | Cc1cc(-n2cccn2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 10463883 | 90608 | 0 | None | - | 0 | Guinea pig | 10.4 | pKd | = | 10.4 | Functional | ChEMBL | 746 | 13 | 2 | 8 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@@H](N)CCCN(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL220596 | 90608 | 0 | None | - | 0 | Guinea pig | 10.4 | pKd | = | 10.4 | Functional | ChEMBL | 746 | 13 | 2 | 8 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@@H](N)CCCN(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 11498853 | 89963 | 13 | None | - | 1 | Human | 10.3 | pKd | = | 10.3 | Functional | ChEMBL | 763 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL218427 | 89963 | 13 | None | - | 1 | Human | 10.3 | pKd | = | 10.3 | Functional | ChEMBL | 763 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL541758 | 89963 | 13 | None | - | 1 | Human | 10.3 | pKd | = | 10.3 | Functional | ChEMBL | 763 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 11498853 | 89963 | 13 | None | - | 1 | Human | 10.3 | pKd | = | 10.3 | Functional | ChEMBL | 763 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL218427 | 89963 | 13 | None | - | 1 | Human | 10.3 | pKd | = | 10.3 | Functional | ChEMBL | 763 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL541758 | 89963 | 13 | None | - | 1 | Human | 10.3 | pKd | = | 10.3 | Functional | ChEMBL | 763 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 57345657 | 78367 | 0 | None | - | 0 | Guinea pig | 10.2 | pKd | = | 10.2 | Functional | ChEMBL | 748 | 12 | 1 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956722 | 78367 | 0 | None | - | 0 | Guinea pig | 10.2 | pKd | = | 10.2 | Functional | ChEMBL | 748 | 12 | 1 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963183 | 78367 | 0 | None | - | 0 | Guinea pig | 10.2 | pKd | = | 10.2 | Functional | ChEMBL | 748 | 12 | 1 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 10439868 | 82701 | 0 | None | - | 0 | Guinea pig | 10.0 | pKd | = | 10 | Functional | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL205093 | 82701 | 0 | None | - | 0 | Guinea pig | 10.0 | pKd | = | 10 | Functional | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10373970 | 144392 | 0 | None | - | 0 | Guinea pig | 10.0 | pKd | = | 10 | Functional | ChEMBL | 760 | 13 | 5 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCNC(=N)N)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL375689 | 144392 | 0 | None | - | 0 | Guinea pig | 10.0 | pKd | = | 10 | Functional | ChEMBL | 760 | 13 | 5 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCNC(=N)N)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10032895 | 144409 | 0 | None | - | 0 | Guinea pig | 10.0 | pKd | = | 10 | Functional | ChEMBL | 734 | 13 | 5 | 8 | 3.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCNC(=N)N)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL375820 | 144409 | 0 | None | - | 0 | Guinea pig | 10.0 | pKd | = | 10 | Functional | ChEMBL | 734 | 13 | 5 | 8 | 3.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCNC(=N)N)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10101294 | 146932 | 0 | None | - | 0 | Guinea pig | 10.0 | pKd | = | 10 | Functional | ChEMBL | 706 | 12 | 2 | 8 | 4.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL380273 | 146932 | 0 | None | - | 0 | Guinea pig | 10.0 | pKd | = | 10 | Functional | ChEMBL | 706 | 12 | 2 | 8 | 4.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 57403503 | 78440 | 0 | None | - | 0 | Human | 9.9 | pKd | = | 9.9 | Functional | ChEMBL | 748 | 12 | 2 | 9 | 3.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCN(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956856 | 78440 | 0 | None | - | 0 | Human | 9.9 | pKd | = | 9.9 | Functional | ChEMBL | 748 | 12 | 2 | 9 | 3.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCN(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963651 | 78440 | 0 | None | - | 0 | Human | 9.9 | pKd | = | 9.9 | Functional | ChEMBL | 748 | 12 | 2 | 9 | 3.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCN(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 16105746 | 168709 | 0 | None | - | 0 | Human | 9.8 | pKd | = | 9.8 | Functional | ChEMBL | 779 | 12 | 2 | 8 | 4.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCSCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL415366 | 168709 | 0 | None | - | 0 | Human | 9.8 | pKd | = | 9.8 | Functional | ChEMBL | 779 | 12 | 2 | 8 | 4.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCSCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 9988753 | 90607 | 0 | None | - | 0 | Guinea pig | 9.8 | pKd | = | 9.8 | Functional | ChEMBL | 746 | 13 | 2 | 8 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL220595 | 90607 | 0 | None | - | 0 | Guinea pig | 9.8 | pKd | = | 9.8 | Functional | ChEMBL | 746 | 13 | 2 | 8 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10010104 | 148052 | 0 | None | - | 0 | Guinea pig | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL383167 | 148052 | 0 | None | - | 0 | Guinea pig | 9.7 | pKd | = | 9.7 | Functional | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 16105703 | 143258 | 0 | None | - | 0 | Human | 9.6 | pKd | = | 9.6 | Functional | ChEMBL | 776 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCN(C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL373607 | 143258 | 0 | None | - | 0 | Human | 9.6 | pKd | = | 9.6 | Functional | ChEMBL | 776 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCN(C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10373970 | 144392 | 0 | None | - | 0 | Human | 9.6 | pKd | = | 9.6 | Functional | ChEMBL | 760 | 13 | 5 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCNC(=N)N)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL375689 | 144392 | 0 | None | - | 0 | Human | 9.6 | pKd | = | 9.6 | Functional | ChEMBL | 760 | 13 | 5 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCNC(=N)N)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 44378635 | 175526 | 0 | None | - | 0 | Human | 9.6 | pKd | = | 9.6 | Functional | ChEMBL | 1351 | 29 | 15 | 18 | -2.0 | C[C@@]12CCCC[C@]1(C)N(C(=O)[C@H]1Cc3ccccc3CN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1cccs1)NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)c1ccc(NC(N)C=N)cc1)[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C2 | 10.1016/S0960-894X(01)80847-7 | ||
| CHEMBL437155 | 175526 | 0 | None | - | 0 | Human | 9.6 | pKd | = | 9.6 | Functional | ChEMBL | 1351 | 29 | 15 | 18 | -2.0 | C[C@@]12CCCC[C@]1(C)N(C(=O)[C@H]1Cc3ccccc3CN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1cccs1)NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)c1ccc(NC(N)C=N)cc1)[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C2 | 10.1016/S0960-894X(01)80847-7 | ||
| 667 | 8754 | 37 | None | -2 | 2 | Human | 9.6 | pKd | = | 9.6 | Functional | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2006.01.125 | ||||
| 6918173 | 8754 | 37 | None | -2 | 2 | Human | 9.6 | pKd | = | 9.6 | Functional | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2006.01.125 | ||||
| 71364 | 8754 | 37 | None | -2 | 2 | Human | 9.6 | pKd | = | 9.6 | Functional | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2006.01.125 | ||||
| CHEMBL2028850 | 8754 | 37 | None | -2 | 2 | Human | 9.6 | pKd | = | 9.6 | Functional | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2006.01.125 | ||||
| DB06196 | 8754 | 37 | None | -2 | 2 | Human | 9.6 | pKd | = | 9.6 | Functional | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2006.01.125 | ||||
| 57345657 | 78367 | 0 | None | - | 0 | Human | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 748 | 12 | 1 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956722 | 78367 | 0 | None | - | 0 | Human | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 748 | 12 | 1 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963183 | 78367 | 0 | None | - | 0 | Human | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 748 | 12 | 1 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 11600324 | 148774 | 0 | None | - | 0 | Human | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 747 | 12 | 2 | 7 | 4.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL387452 | 148774 | 0 | None | - | 0 | Human | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 747 | 12 | 2 | 7 | 4.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 44412007 | 83986 | 1 | None | - | 0 | Guinea pig | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 710 | 12 | 4 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)N4CCC[C@@H]4C(=O)NCCCNC(=O)c4ccc(C(=N)N)cc4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL207939 | 83986 | 1 | None | - | 0 | Guinea pig | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | 710 | 12 | 4 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)N4CCC[C@@H]4C(=O)NCCCNC(=O)c4ccc(C(=N)N)cc4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 667 | 8754 | 37 | None | - | 2 | Rat | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | None | None | None | None | 10.1021/jm950716i | ||||
| 6918173 | 8754 | 37 | None | - | 2 | Rat | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | None | None | None | None | 10.1021/jm950716i | ||||
| 71364 | 8754 | 37 | None | - | 2 | Rat | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | None | None | None | None | 10.1021/jm950716i | ||||
| CHEMBL2028850 | 8754 | 37 | None | - | 2 | Rat | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | None | None | None | None | 10.1021/jm950716i | ||||
| DB06196 | 8754 | 37 | None | - | 2 | Rat | 9.5 | pKd | = | 9.5 | Functional | ChEMBL | None | None | None | None | 10.1021/jm950716i | ||||
| 57399983 | 78350 | 0 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 777 | 13 | 2 | 8 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956859 | 78350 | 0 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 777 | 13 | 2 | 8 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963149 | 78350 | 0 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 777 | 13 | 2 | 8 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57401772 | 78363 | 0 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 734 | 12 | 3 | 9 | 3.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956857 | 78363 | 0 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 734 | 12 | 3 | 9 | 3.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963175 | 78363 | 0 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 734 | 12 | 3 | 9 | 3.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 44412007 | 83986 | 1 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 710 | 12 | 4 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)N4CCC[C@@H]4C(=O)NCCCNC(=O)c4ccc(C(=N)N)cc4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL207939 | 83986 | 1 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 710 | 12 | 4 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)N4CCC[C@@H]4C(=O)NCCCNC(=O)c4ccc(C(=N)N)cc4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 57401770 | 78358 | 0 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 733 | 12 | 1 | 8 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCN(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956853 | 78358 | 0 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 733 | 12 | 1 | 8 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCN(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963162 | 78358 | 0 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 733 | 12 | 1 | 8 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCN(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57396534 | 78439 | 0 | None | - | 0 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 705 | 11 | 2 | 8 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCN)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956854 | 78439 | 0 | None | - | 0 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 705 | 11 | 2 | 8 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCN)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963650 | 78439 | 0 | None | - | 0 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 705 | 11 | 2 | 8 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCN)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL3038099 | 217711 | 0 | None | - | 0 | Rat | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C1CCCCC1 | 10.1021/jm950716i | ||||
| 10079793 | 100895 | 0 | None | - | 0 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 717 | 11 | 3 | 7 | 4.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=N)NCCCN(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL249235 | 100895 | 0 | None | - | 0 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 717 | 11 | 3 | 7 | 4.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=N)NCCCN(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 16105698 | 143124 | 0 | None | - | 0 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 747 | 12 | 2 | 7 | 4.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCN)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL373459 | 143124 | 0 | None | - | 0 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 747 | 12 | 2 | 7 | 4.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCN)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10079797 | 144375 | 0 | None | - | 0 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 718 | 12 | 3 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@@H](N)CCCN)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL375576 | 144375 | 0 | None | - | 0 | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 718 | 12 | 3 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@@H](N)CCCN)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 16105734 | 91047 | 0 | None | - | 0 | Human | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 803 | 14 | 4 | 7 | 4.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCCNC(=N)N)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL221285 | 91047 | 0 | None | - | 0 | Human | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 803 | 14 | 4 | 7 | 4.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCCNC(=N)N)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 57394782 | 78418 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 720 | 11 | 3 | 9 | 3.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCN)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956855 | 78418 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 720 | 11 | 3 | 9 | 3.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCN)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963557 | 78418 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 720 | 11 | 3 | 9 | 3.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCN)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 10101294 | 146932 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 706 | 12 | 2 | 8 | 4.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL380273 | 146932 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 706 | 12 | 2 | 8 | 4.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 57399228 | 78347 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 706 | 9 | 1 | 7 | 3.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956720 | 78347 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 706 | 9 | 1 | 7 | 3.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963146 | 78347 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 706 | 9 | 1 | 7 | 3.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57402746 | 78348 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 734 | 11 | 1 | 7 | 4.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956721 | 78348 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 734 | 11 | 1 | 7 | 4.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963147 | 78348 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 734 | 11 | 1 | 7 | 4.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57401778 | 78353 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 748 | 14 | 1 | 7 | 6.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(CCCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956870 | 78353 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 748 | 14 | 1 | 7 | 6.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(CCCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963152 | 78353 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 748 | 14 | 1 | 7 | 6.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(CCCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57400986 | 78357 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 762 | 13 | 1 | 7 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956723 | 78357 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 762 | 13 | 1 | 7 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963161 | 78357 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 762 | 13 | 1 | 7 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 9988753 | 90607 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 746 | 13 | 2 | 8 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL220595 | 90607 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 746 | 13 | 2 | 8 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10418701 | 103877 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 760 | 13 | 5 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@@H](N)CCCNC(=N)N)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL267493 | 103877 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 760 | 13 | 5 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@@H](N)CCCNC(=N)N)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10032895 | 144409 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 734 | 13 | 5 | 8 | 3.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCNC(=N)N)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL375820 | 144409 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 734 | 13 | 5 | 8 | 3.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCNC(=N)N)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10101294 | 146932 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 706 | 12 | 2 | 8 | 4.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL380273 | 146932 | 0 | None | - | 0 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 706 | 12 | 2 | 8 | 4.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL3038100 | 217712 | 0 | None | - | 0 | Rat | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | None | None | None | N=C(N)NCCCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N1C[C@@H](O)C[C@@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C1CCCCC1 | 10.1021/jm950716i | ||||
| 667 | 8754 | 37 | None | -2 | 2 | Human | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)80847-7 | ||||
| 6918173 | 8754 | 37 | None | -2 | 2 | Human | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)80847-7 | ||||
| 71364 | 8754 | 37 | None | -2 | 2 | Human | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)80847-7 | ||||
| CHEMBL2028850 | 8754 | 37 | None | -2 | 2 | Human | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)80847-7 | ||||
| DB06196 | 8754 | 37 | None | -2 | 2 | Human | 9.0 | pKd | = | 9.0 | Functional | ChEMBL | None | None | None | None | 10.1016/S0960-894X(01)80847-7 | ||||
| 57396538 | 78364 | 0 | None | - | 0 | Human | 9.0 | pKd | = | 9 | Functional | ChEMBL | 721 | 11 | 1 | 6 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956861 | 78364 | 0 | None | - | 0 | Human | 9.0 | pKd | = | 9 | Functional | ChEMBL | 721 | 11 | 1 | 6 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963176 | 78364 | 0 | None | - | 0 | Human | 9.0 | pKd | = | 9 | Functional | ChEMBL | 721 | 11 | 1 | 6 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57394780 | 78417 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 776 | 14 | 1 | 7 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956852 | 78417 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 776 | 14 | 1 | 7 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963556 | 78417 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 776 | 14 | 1 | 7 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 16105751 | 90004 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 804 | 12 | 2 | 8 | 3.9 | CC(=O)N1CCC(NS(=O)(=O)c2ccc(Cl)c(COc3cccc4c(C)cc(C)nc34)c2Cl)(C(=O)N2CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC2)CC1 | 10.1021/jm061143k | ||
| CHEMBL218636 | 90004 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 804 | 12 | 2 | 8 | 3.9 | CC(=O)N1CCC(NS(=O)(=O)c2ccc(Cl)c(COc3cccc4c(C)cc(C)nc34)c2Cl)(C(=O)N2CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC2)CC1 | 10.1021/jm061143k | ||
| 16105690 | 90409 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 761 | 13 | 2 | 7 | 5.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@H](CCCN)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL220478 | 90409 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 761 | 13 | 2 | 7 | 5.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@H](CCCN)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 16105729 | 143712 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 761 | 13 | 2 | 7 | 5.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL374273 | 143712 | 0 | None | - | 0 | Human | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 761 | 13 | 2 | 7 | 5.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL3038095 | 217708 | 0 | None | - | 0 | Rat | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)c1ccccc1 | 10.1021/jm950716i | ||||
| CHEMBL2371961 | 216937 | 0 | None | - | 0 | Guinea pig | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@@H]1CN(C(=O)[C@H]2c3ccccc3CCN2C(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C2CCCCC21)C(=O)O | 10.1021/jm00069a016 | ||||
| 57401776 | 78351 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 690 | 7 | 1 | 7 | 4.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CCN(C)CC6)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956866 | 78351 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 690 | 7 | 1 | 7 | 4.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CCN(C)CC6)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963150 | 78351 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 690 | 7 | 1 | 7 | 4.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CCN(C)CC6)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57401782 | 78361 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 705 | 11 | 1 | 6 | 6.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956873 | 78361 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 705 | 11 | 1 | 6 | 6.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963165 | 78361 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 705 | 11 | 1 | 6 | 6.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 10463883 | 90608 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 746 | 13 | 2 | 8 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@@H](N)CCCN(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL220596 | 90608 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 746 | 13 | 2 | 8 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@@H](N)CCCN(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 16105701 | 90744 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 762 | 12 | 3 | 8 | 3.6 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCNCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL220693 | 90744 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 762 | 12 | 3 | 8 | 3.6 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCNCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10441167 | 103763 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 732 | 11 | 3 | 6 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=N)NCCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL266493 | 103763 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 732 | 11 | 3 | 6 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=N)NCCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10102701 | 144216 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 761 | 13 | 2 | 7 | 5.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCCN)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL375354 | 144216 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 761 | 13 | 2 | 7 | 5.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCCN)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 16105694 | 148672 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 732 | 12 | 1 | 6 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL386794 | 148672 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 732 | 12 | 1 | 6 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 9897921 | 168680 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 761 | 13 | 2 | 7 | 5.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@@H](N)CCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL415151 | 168680 | 0 | None | - | 0 | Human | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 761 | 13 | 2 | 7 | 5.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@@H](N)CCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL2372283 | 216988 | 0 | None | - | 0 | Rat | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)N1C[C@@H](O)C[C@@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C1CCCCC1 | 10.1021/jm950716i | ||||
| 57398324 | 78360 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 735 | 12 | 1 | 6 | 5.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956862 | 78360 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 735 | 12 | 1 | 6 | 5.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963164 | 78360 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 735 | 12 | 1 | 6 | 5.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 16105727 | 90586 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 718 | 12 | 3 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL220591 | 90586 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 718 | 12 | 3 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10396101 | 91117 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 718 | 11 | 1 | 6 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL221683 | 91117 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 718 | 11 | 1 | 6 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10441194 | 91397 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 745 | 13 | 4 | 7 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCCNC(=N)N)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL222156 | 91397 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 745 | 13 | 4 | 7 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCCNC(=N)N)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 16105742 | 144932 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 733 | 11 | 2 | 7 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL376866 | 144932 | 0 | None | - | 0 | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 733 | 11 | 2 | 7 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10418495 | 84650 | 0 | None | - | 0 | Human | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 649 | 10 | 4 | 7 | 3.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=N)NCCCN)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL209346 | 84650 | 0 | None | - | 0 | Human | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 649 | 10 | 4 | 7 | 3.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=N)NCCCN)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 44354187 | 123578 | 0 | None | - | 0 | Guinea pig | 6.0 | pKd | = | 6 | Functional | ChEMBL | 925 | 29 | 11 | 10 | 0.2 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)O)C[C@H]2CCCC[C@H]21)C1Cc2ccccc2C1 | 10.1021/jm980495r | ||
| CHEMBL337833 | 123578 | 0 | None | - | 0 | Guinea pig | 6.0 | pKd | = | 6 | Functional | ChEMBL | 925 | 29 | 11 | 10 | 0.2 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)O)C[C@H]2CCCC[C@H]21)C1Cc2ccccc2C1 | 10.1021/jm980495r | ||
| CHEMBL410363 | 219595 | 24 | None | - | 0 | Guinea pig | 6.0 | pKd | = | 6 | Functional | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)O | 10.1021/jm980495r | ||||
| 10010669 | 83586 | 0 | None | - | 0 | Human | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 706 | 13 | 2 | 8 | 4.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL206938 | 83586 | 0 | None | - | 0 | Human | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 706 | 13 | 2 | 8 | 4.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 70685700 | 81278 | 0 | None | - | 0 | Rabbit | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 670 | 6 | 6 | 6 | 0.7 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](Cc2ccccc2)NC(=O)CNC1=O | 10.1021/jm950682e | ||
| CHEMBL2028840 | 81278 | 0 | None | - | 0 | Rabbit | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 670 | 6 | 6 | 6 | 0.7 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](Cc2ccccc2)NC(=O)CNC1=O | 10.1021/jm950682e | ||
| CHEMBL2370040 | 216552 | 0 | None | - | 0 | Guinea pig | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | None | None | None | C[C@@](Cc1ccccc1)(NC(=O)CNC(=O)[C@@H]1C[C@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm00069a016 | ||||
| 44354059 | 123837 | 0 | None | - | 0 | Guinea pig | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | 925 | 34 | 11 | 10 | 1.8 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CO)NC(=O)CCCCCCCCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)O | 10.1021/jm980495r | ||
| CHEMBL339159 | 123837 | 0 | None | - | 0 | Guinea pig | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | 925 | 34 | 11 | 10 | 1.8 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CO)NC(=O)CCCCCCCCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)O | 10.1021/jm980495r | ||
| CHEMBL3038103 | 217715 | 0 | None | - | 1 | Rat | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C1CCCCC1)C1CCCC1 | 10.1021/jm950716i | ||||
| 70685699 | 81272 | 0 | None | - | 0 | Rabbit | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 747 | 10 | 6 | 9 | 1.1 | NCCCC[C@@H]1N[C@@H](Cc2cccs2)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2C3CCCCC3C[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC1=O | 10.1021/jm950682e | ||
| CHEMBL2028835 | 81272 | 0 | None | - | 0 | Rabbit | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 747 | 10 | 6 | 9 | 1.1 | NCCCC[C@@H]1N[C@@H](Cc2cccs2)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2C3CCCCC3C[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC1=O | 10.1021/jm950682e | ||
| CHEMBL3038104 | 217716 | 0 | None | - | 1 | Rat | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)O)C1CCCCC1 | 10.1021/jm950716i | ||||
| CHEMBL3038096 | 217709 | 0 | None | - | 1 | Rat | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C1CCCCC1 | 10.1021/jm950716i | ||||
| 10056816 | 84524 | 0 | None | - | 0 | Human | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 649 | 13 | 2 | 7 | 5.1 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(CCCCCCN)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL209038 | 84524 | 0 | None | - | 0 | Human | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 649 | 13 | 2 | 7 | 5.1 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(CCCCCCN)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11513471 | 145425 | 0 | None | - | 0 | Human | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 748 | 14 | 2 | 8 | 4.4 | CC(=O)N[C@@H](CCCCN(C)C)C(=O)N1CCN(C(=O)C(C)(C)NS(=O)(=O)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)CC1 | 10.1021/jm060137l | ||
| CHEMBL377612 | 145425 | 0 | None | - | 0 | Human | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 748 | 14 | 2 | 8 | 4.4 | CC(=O)N[C@@H](CCCCN(C)C)C(=O)N1CCN(C(=O)C(C)(C)NS(=O)(=O)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)CC1 | 10.1021/jm060137l | ||
| 56668285 | 70092 | 0 | None | - | 0 | Guinea pig | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 1145 | 26 | 13 | 15 | -1.1 | C=C([C@H]1Cc2ccccc2CN1C(=O)[C@H](CO)CC(=O)[C@H](Cc1cccs1)NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCNC(=N)N)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| CHEMBL1793829 | 70092 | 0 | None | - | 0 | Guinea pig | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 1145 | 26 | 13 | 15 | -1.1 | C=C([C@H]1Cc2ccccc2CN1C(=O)[C@H](CO)CC(=O)[C@H](Cc1cccs1)NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCNC(=N)N)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| 10439868 | 82701 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL205093 | 82701 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11600186 | 85072 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 734 | 14 | 2 | 8 | 4.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL210788 | 85072 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 734 | 14 | 2 | 8 | 4.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10418252 | 145669 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 663 | 10 | 4 | 7 | 3.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=N)NCCCN)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL378237 | 145669 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 663 | 10 | 4 | 7 | 3.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=N)NCCCN)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 57401774 | 78368 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 749 | 13 | 1 | 6 | 5.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956863 | 78368 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 749 | 13 | 1 | 6 | 5.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963184 | 78368 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 749 | 13 | 1 | 6 | 5.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57391279 | 78369 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 748 | 14 | 2 | 7 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CNCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956876 | 78369 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 748 | 14 | 2 | 7 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CNCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963185 | 78369 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 748 | 14 | 2 | 7 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CNCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57401784 | 78414 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 734 | 13 | 2 | 7 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CNCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956875 | 78414 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 734 | 13 | 2 | 7 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CNCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963532 | 78414 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 734 | 13 | 2 | 7 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CNCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57392147 | 78444 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 720 | 12 | 2 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CNCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1955876 | 78444 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 720 | 12 | 2 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CNCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963660 | 78444 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 720 | 12 | 2 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CNCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 10439868 | 82701 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL205093 | 82701 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 16105696 | 89983 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 790 | 13 | 1 | 6 | 5.6 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCC[N+](C)(C)C)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL218540 | 89983 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 790 | 13 | 1 | 6 | 5.6 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCC[N+](C)(C)C)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 57403505 | 78420 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 675 | 7 | 1 | 6 | 5.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CCCCC6)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956865 | 78420 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 675 | 7 | 1 | 6 | 5.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CCCCC6)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963559 | 78420 | 0 | None | - | 0 | Human | 8.6 | pKd | = | 8.6 | Functional | ChEMBL | 675 | 7 | 1 | 6 | 5.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CCCCC6)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL3038101 | 217713 | 0 | None | - | 0 | Rat | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)c1ccccc1 | 10.1021/jm950716i | ||||
| CHEMBL3038105 | 217717 | 0 | None | - | 1 | Rat | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N(CC(=O)N1C2CCCCC2C[C@H]1C(=O)O)Cc1ccccc1 | 10.1021/jm950716i | ||||
| 70696204 | 81273 | 0 | None | - | 0 | Rabbit | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 690 | 6 | 4 | 7 | 0.9 | CN1CC(=O)N[C@@H](Cc2cccs2)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2C3CCCCC3C[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C1=O | 10.1021/jm950682e | ||
| CHEMBL2028836 | 81273 | 0 | None | - | 0 | Rabbit | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 690 | 6 | 4 | 7 | 0.9 | CN1CC(=O)N[C@@H](Cc2cccs2)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2C3CCCCC3C[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C1=O | 10.1021/jm950682e | ||
| CHEMBL2372278 | 216986 | 0 | None | - | 0 | Rat | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | None | None | None | N=C(N)NCCCCC(=O)N1CCC[C@@H]1C(=O)N1C[C@@H](O)C[C@@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C1CCCCC1 | 10.1021/jm950716i | ||||
| CHEMBL2370010 | 216546 | 0 | None | - | 0 | Guinea pig | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@@H]1C2CCCCC2CN1C(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](CO)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N2CCC[C@H]2C(=O)NCC(=O)N1)C(=O)O | 10.1021/jm00069a016 | ||||
| 70687850 | 81279 | 0 | None | - | 0 | Rabbit | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 594 | 4 | 5 | 6 | -0.7 | C[C@@H]1NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C1=O | 10.1021/jm950682e | ||
| CHEMBL2028841 | 81279 | 0 | None | - | 0 | Rabbit | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 594 | 4 | 5 | 6 | -0.7 | C[C@@H]1NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C1=O | 10.1021/jm950682e | ||
| 11506007 | 84786 | 0 | None | - | 0 | Human | 7.6 | pKd | = | 7.6 | Functional | ChEMBL | 676 | 9 | 2 | 8 | 3.1 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)CN5CCNCC5)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL209773 | 84786 | 0 | None | - | 0 | Human | 7.6 | pKd | = | 7.6 | Functional | ChEMBL | 676 | 9 | 2 | 8 | 3.1 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)CN5CCNCC5)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10463758 | 145649 | 0 | None | - | 0 | Human | 7.6 | pKd | = | 7.6 | Functional | ChEMBL | 692 | 12 | 2 | 8 | 3.8 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL378189 | 145649 | 0 | None | - | 0 | Human | 7.6 | pKd | = | 7.6 | Functional | ChEMBL | 692 | 12 | 2 | 8 | 3.8 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 90662813 | 113344 | 0 | None | - | 0 | Rabbit | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 722 | 15 | 6 | 8 | 1.3 | NCCCC(=O)N[C@@H](Cc1cccs1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm950682e | ||
| CHEMBL3142191 | 113344 | 0 | None | - | 0 | Rabbit | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 722 | 15 | 6 | 8 | 1.3 | NCCCC(=O)N[C@@H](Cc1cccs1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm950682e | ||
| CHEMBL2370042 | 216554 | 0 | None | - | 0 | Guinea pig | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | None | None | None | CN(C(=O)CNC(=O)[C@@H]1C[C@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm00069a016 | ||||
| 44410425 | 103914 | 0 | None | - | 0 | Human | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 1332 | 32 | 16 | 17 | -4.3 | NC(N)=NCCC[C@H](NC(=O)[C@@H]1CC2(CCCC2)C2CCC[C@](Cc3ccccc3)(NC(=O)[C@H](CO)NC(=O)[C@H](Cc3cccs3)NC(=O)CNC(=O)[C@@H]3CC(O)CN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N21)C(=O)O | 10.1016/j.bmcl.2006.01.125 | ||
| CHEMBL267822 | 103914 | 0 | None | - | 0 | Human | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 1332 | 32 | 16 | 17 | -4.3 | NC(N)=NCCC[C@H](NC(=O)[C@@H]1CC2(CCCC2)C2CCC[C@](Cc3ccccc3)(NC(=O)[C@H](CO)NC(=O)[C@H](Cc3cccs3)NC(=O)CNC(=O)[C@@H]3CC(O)CN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N21)C(=O)O | 10.1016/j.bmcl.2006.01.125 | ||
| 10010104 | 148052 | 0 | None | - | 0 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL383167 | 148052 | 0 | None | - | 0 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 57396536 | 78359 | 0 | None | - | 0 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 707 | 10 | 1 | 6 | 4.6 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956860 | 78359 | 0 | None | - | 0 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 707 | 10 | 1 | 6 | 4.6 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963163 | 78359 | 0 | None | - | 0 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 707 | 10 | 1 | 6 | 4.6 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57393060 | 78362 | 0 | None | - | 0 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 661 | 7 | 1 | 6 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CCCC6)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956851 | 78362 | 0 | None | - | 0 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 661 | 7 | 1 | 6 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CCCC6)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963174 | 78362 | 0 | None | - | 0 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 661 | 7 | 1 | 6 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CCCC6)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57398326 | 78419 | 0 | None | - | 0 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 763 | 14 | 1 | 6 | 6.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956864 | 78419 | 0 | None | - | 0 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 763 | 14 | 1 | 6 | 6.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963558 | 78419 | 0 | None | - | 0 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 763 | 14 | 1 | 6 | 6.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 11766718 | 143711 | 0 | None | - | 0 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 774 | 14 | 1 | 8 | 5.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCCN(C)C)N(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL374272 | 143711 | 0 | None | - | 0 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 774 | 14 | 1 | 8 | 5.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCCN(C)C)N(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10010104 | 148052 | 0 | None | - | 0 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL383167 | 148052 | 0 | None | - | 0 | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL3038094 | 217707 | 0 | None | - | 0 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C1CCCC1 | 10.1021/jm950716i | ||||
| CHEMBL3038106 | 217718 | 0 | None | - | 0 | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H](O)C[C@@H]1C(=O)N1C[C@@H](O)C[C@@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C1CCCCC1 | 10.1021/jm950716i | ||||
| 57401780 | 78354 | 0 | None | - | 0 | Human | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 691 | 10 | 1 | 6 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956872 | 78354 | 0 | None | - | 0 | Human | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 691 | 10 | 1 | 6 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963153 | 78354 | 0 | None | - | 0 | Human | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 691 | 10 | 1 | 6 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57398328 | 78443 | 0 | None | - | 0 | Human | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 719 | 12 | 1 | 6 | 6.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956874 | 78443 | 0 | None | - | 0 | Human | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 719 | 12 | 1 | 6 | 6.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963659 | 78443 | 0 | None | - | 0 | Human | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 719 | 12 | 1 | 6 | 6.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 90662795 | 113341 | 0 | None | - | 0 | Rabbit | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | 778 | 17 | 9 | 8 | 1.4 | N=C(N)NCCCCC(=O)N[C@@H](Cc1cccs1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm950682e | ||
| CHEMBL3142173 | 113341 | 0 | None | - | 0 | Rabbit | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | 778 | 17 | 9 | 8 | 1.4 | N=C(N)NCCCCC(=O)N[C@@H](Cc1cccs1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm950682e | ||
| 70681476 | 81281 | 0 | None | - | 0 | Rabbit | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 709 | 5 | 7 | 8 | -1.5 | C[C@@H]1NC(=O)CCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](CO)NC1=O | 10.1021/jm950682e | ||
| CHEMBL2028844 | 81281 | 0 | None | - | 0 | Rabbit | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 709 | 5 | 7 | 8 | -1.5 | C[C@@H]1NC(=O)CCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](CO)NC1=O | 10.1021/jm950682e | ||
| 44354175 | 103683 | 0 | None | - | 0 | Guinea pig | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | 1025 | 35 | 12 | 12 | 0.8 | NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N1[C@H]2CCCC[C@H]2C[C@@H]1C(=O)O)C1Cc2ccccc2C1 | 10.1021/jm980495r | ||
| CHEMBL265814 | 103683 | 0 | None | - | 0 | Guinea pig | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | 1025 | 35 | 12 | 12 | 0.8 | NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N1[C@H]2CCCC[C@H]2C[C@@H]1C(=O)O)C1Cc2ccccc2C1 | 10.1021/jm980495r | ||
| CHEMBL2370700 | 216695 | 0 | None | - | 0 | Guinea pig | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | None | None | None | NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21)C1Cc2ccccc2C1)C1Cc2ccccc2C1 | 10.1021/jm980495r | ||||
| 70696205 | 81276 | 0 | None | - | 0 | Rabbit | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 704 | 6 | 6 | 7 | 1.5 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](Cc2cccs2)NC(=O)CCCNC1=O | 10.1021/jm950682e | ||
| CHEMBL2028839 | 81276 | 0 | None | - | 0 | Rabbit | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 704 | 6 | 6 | 7 | 1.5 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](Cc2cccs2)NC(=O)CCCNC1=O | 10.1021/jm950682e | ||
| 90662796 | 113342 | 0 | None | - | 0 | Rabbit | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | 792 | 18 | 9 | 8 | 1.8 | N=C(N)NCCCCCC(=O)N[C@@H](Cc1cccs1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm950682e | ||
| CHEMBL3142174 | 113342 | 0 | None | - | 0 | Rabbit | 5.5 | pKd | = | 5.5 | Functional | ChEMBL | 792 | 18 | 9 | 8 | 1.8 | N=C(N)NCCCCCC(=O)N[C@@H](Cc1cccs1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/jm950682e | ||
| 90662812 | 113343 | 0 | None | - | 0 | Rabbit | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 716 | 15 | 6 | 7 | 1.2 | NCCCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm950682e | ||
| CHEMBL3142190 | 113343 | 0 | None | - | 0 | Rabbit | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 716 | 15 | 6 | 7 | 1.2 | NCCCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm950682e | ||
| 11527838 | 85133 | 0 | None | - | 0 | Human | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 635 | 10 | 3 | 7 | 2.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(CCN=C(N)N)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL211017 | 85133 | 0 | None | - | 0 | Human | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 635 | 10 | 3 | 7 | 2.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(CCN=C(N)N)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10008626 | 145456 | 0 | None | - | 0 | Human | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 592 | 7 | 3 | 6 | 3.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=N)N)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL377800 | 145456 | 0 | None | - | 0 | Human | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 592 | 7 | 3 | 6 | 3.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=N)N)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10463818 | 146050 | 0 | None | - | 0 | Human | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 720 | 14 | 2 | 8 | 4.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL379063 | 146050 | 0 | None | - | 0 | Human | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 720 | 14 | 2 | 8 | 4.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10102599 | 148182 | 0 | None | - | 0 | Human | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 706 | 13 | 2 | 8 | 4.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL383989 | 148182 | 0 | None | - | 0 | Human | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 706 | 13 | 2 | 8 | 4.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 44354176 | 103530 | 0 | None | - | 0 | Guinea pig | 5.4 | pKd | = | 5.4 | Functional | ChEMBL | 925 | 28 | 10 | 10 | 0.6 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| CHEMBL264517 | 103530 | 0 | None | - | 0 | Guinea pig | 5.4 | pKd | = | 5.4 | Functional | ChEMBL | 925 | 28 | 10 | 10 | 0.6 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21 | 10.1021/jm980495r | ||
| 10032469 | 81275 | 0 | None | - | 0 | Rabbit | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 676 | 6 | 6 | 7 | 0.8 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](Cc2cccs2)NC(=O)CNC1=O | 10.1021/jm950682e | ||
| CHEMBL2028838 | 81275 | 0 | None | - | 0 | Rabbit | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 676 | 6 | 6 | 7 | 0.8 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](Cc2cccs2)NC(=O)CNC1=O | 10.1021/jm950682e | ||
| 70696206 | 81284 | 0 | None | - | 0 | Rabbit | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 797 | 5 | 7 | 8 | 0.2 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](CO)NC(=O)[C@@H]2Cc3ccccc3CN2C(=O)CCCNC1=O | 10.1021/jm950682e | ||
| CHEMBL2028847 | 81284 | 0 | None | - | 0 | Rabbit | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 797 | 5 | 7 | 8 | 0.2 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](CO)NC(=O)[C@@H]2Cc3ccccc3CN2C(=O)CCCNC1=O | 10.1021/jm950682e | ||
| 70696207 | 81286 | 0 | None | - | 0 | Rabbit | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 791 | 7 | 8 | 9 | 0.0 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CCCNC1=O | 10.1021/jm950682e | ||
| CHEMBL2028849 | 81286 | 0 | None | - | 0 | Rabbit | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 791 | 7 | 8 | 9 | 0.0 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CCCNC1=O | 10.1021/jm950682e | ||
| 90662814 | 113345 | 0 | None | - | 0 | Rabbit | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 806 | 21 | 6 | 8 | 3.6 | NCCCCCCCCCC(=O)N[C@@H](Cc1cccs1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm950682e | ||
| CHEMBL3142192 | 113345 | 0 | None | - | 0 | Rabbit | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 806 | 21 | 6 | 8 | 3.6 | NCCCCCCCCCC(=O)N[C@@H](Cc1cccs1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm950682e | ||
| 70694084 | 81280 | 0 | None | - | 0 | Rabbit | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 808 | 6 | 7 | 7 | 1.3 | C[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C1=O | 10.1021/jm950682e | ||
| CHEMBL2028843 | 81280 | 0 | None | - | 0 | Rabbit | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 808 | 6 | 7 | 7 | 1.3 | C[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C1=O | 10.1021/jm950682e | ||
| 57396540 | 78365 | 0 | None | - | 0 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 705 | 7 | 1 | 6 | 4.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CC5)CC[N+](C)(C)CC6)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956867 | 78365 | 0 | None | - | 0 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 705 | 7 | 1 | 6 | 4.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CC5)CC[N+](C)(C)CC6)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963177 | 78365 | 0 | None | - | 0 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 705 | 7 | 1 | 6 | 4.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CC5)CC[N+](C)(C)CC6)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57394784 | 78442 | 0 | None | - | 0 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 677 | 9 | 1 | 6 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(C[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956871 | 78442 | 0 | None | - | 0 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 677 | 9 | 1 | 6 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(C[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963658 | 78442 | 0 | None | - | 0 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 677 | 9 | 1 | 6 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(C[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 10350966 | 91399 | 0 | None | - | 0 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 746 | 13 | 1 | 6 | 6.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL222167 | 91399 | 0 | None | - | 0 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 746 | 13 | 1 | 6 | 6.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10102296 | 168681 | 0 | None | - | 0 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 690 | 9 | 1 | 6 | 4.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL415152 | 168681 | 0 | None | - | 0 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 690 | 9 | 1 | 6 | 4.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL3038102 | 217714 | 0 | None | - | 0 | Rat | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N(CC(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)Cc1ccccc1 | 10.1021/jm950716i | ||||
| CHEMBL2370011 | 216547 | 0 | None | - | 0 | Guinea pig | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@@H]1C2CCCCC2CN1C(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)O | 10.1021/jm00069a016 | ||||
| CHEMBL2372276 | 216985 | 0 | None | - | 1 | Rat | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)[C@@H]1CCCN1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CCCN=C(N)N)C(=O)O | 10.1021/jm950716i | ||||
| 70694085 | 81283 | 0 | None | - | 0 | Rabbit | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 771 | 6 | 8 | 8 | 0.1 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](CO)NC(=O)[C@H](c2ccccc2)NC(=O)CCCNC1=O | 10.1021/jm950682e | ||
| CHEMBL2028846 | 81283 | 0 | None | - | 0 | Rabbit | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 771 | 6 | 8 | 8 | 0.1 | N=C(N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](CO)NC(=O)[C@H](c2ccccc2)NC(=O)CCCNC1=O | 10.1021/jm950682e | ||
| 10441297 | 143666 | 0 | None | - | 0 | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 804 | 14 | 1 | 6 | 6.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCC[N+](C)(C)C)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL374224 | 143666 | 0 | None | - | 0 | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 804 | 14 | 1 | 6 | 6.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCC[N+](C)(C)C)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL2370699 | 216694 | 7 | None | - | 0 | Guinea pig | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1C(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C1Cc2ccccc2C1)C(=O)O | 10.1021/jm980495r | ||||
| 70681477 | 81282 | 0 | None | - | 0 | Rabbit | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 775 | 6 | 6 | 8 | 0.8 | C[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)CCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C1=O | 10.1021/jm950682e | ||
| CHEMBL2028845 | 81282 | 0 | None | - | 0 | Rabbit | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 775 | 6 | 6 | 8 | 0.8 | C[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)CCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C1=O | 10.1021/jm950682e | ||
| 10349694 | 83358 | 0 | None | - | 0 | Human | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 691 | 13 | 4 | 7 | 4.7 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=N)NCCCCCCN)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL206312 | 83358 | 0 | None | - | 0 | Human | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 691 | 13 | 4 | 7 | 4.7 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=N)NCCCCCCN)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10055774 | 83478 | 0 | None | - | 0 | Human | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 734 | 14 | 4 | 8 | 3.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCCN=C(N)N)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL206474 | 83478 | 0 | None | - | 0 | Human | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 734 | 14 | 4 | 8 | 3.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCCN=C(N)N)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10260476 | 84772 | 0 | None | - | 0 | Human | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 691 | 14 | 3 | 7 | 4.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(CCCCCCN=C(N)N)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL209719 | 84772 | 0 | None | - | 0 | Human | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 691 | 14 | 3 | 7 | 4.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(CCCCCCN=C(N)N)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL2372276 | 216985 | 0 | None | - | 1 | Rabbit | 5.1 | pKd | = | 5.1 | Functional | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)[C@@H]1CCCN1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CCCN=C(N)N)C(=O)O | 10.1021/jm950682e | ||||
| 70692045 | 81274 | 0 | None | - | 0 | Rabbit | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 775 | 10 | 9 | 8 | 0.4 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](Cc2cccs2)NC1=O | 10.1021/jm950682e | ||
| CHEMBL2028837 | 81274 | 0 | None | - | 0 | Rabbit | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 775 | 10 | 9 | 8 | 0.4 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](Cc2cccs2)NC1=O | 10.1021/jm950682e | ||
| 70689879 | 81285 | 0 | None | - | 0 | Rabbit | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 777 | 7 | 7 | 9 | -0.6 | C[C@@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC1=O | 10.1021/jm950682e | ||
| CHEMBL2028848 | 81285 | 0 | None | - | 0 | Rabbit | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 777 | 7 | 7 | 9 | -0.6 | C[C@@H]1NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC1=O | 10.1021/jm950682e | ||
| 44354174 | 148337 | 0 | None | - | 0 | Guinea pig | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 1081 | 35 | 14 | 12 | -1.3 | NC(N)=NCCC[C@H](NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1C(=O)[C@H](NC(=O)[C@H](CO)NC(=O)CCCCCCCCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(=O)O | 10.1021/jm980495r | ||
| CHEMBL384846 | 148337 | 0 | None | - | 0 | Guinea pig | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 1081 | 35 | 14 | 12 | -1.3 | NC(N)=NCCC[C@H](NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2N1C(=O)[C@H](NC(=O)[C@H](CO)NC(=O)CCCCCCCCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(=O)O | 10.1021/jm980495r | ||
| 73345363 | 96116 | 0 | None | - | 0 | Rabbit | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 793 | 17 | 8 | 9 | -0.1 | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](Cc1cccs1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm950682e | ||
| CHEMBL2369364 | 96116 | 0 | None | - | 0 | Rabbit | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 793 | 17 | 8 | 9 | -0.1 | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](Cc1cccs1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm950682e | ||
| 73354461 | 96127 | 0 | None | - | 0 | Rabbit | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 688 | 13 | 6 | 7 | 0.4 | NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm950682e | ||
| CHEMBL2369400 | 96127 | 0 | None | - | 0 | Rabbit | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 688 | 13 | 6 | 7 | 0.4 | NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm950682e | ||
| 73354460 | 96125 | 0 | None | - | 0 | Rabbit | 6.0 | pKd | = | 6.0 | Functional | ChEMBL | 718 | 14 | 7 | 8 | -0.2 | NC(N)=NCCC[C@H](NC(=O)[C@@H]1CC2CCCCC2N1C(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)O | 10.1021/jm950682e | ||
| CHEMBL2369392 | 96125 | 0 | None | - | 0 | Rabbit | 6.0 | pKd | = | 6.0 | Functional | ChEMBL | 718 | 14 | 7 | 8 | -0.2 | NC(N)=NCCC[C@H](NC(=O)[C@@H]1CC2CCCCC2N1C(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)O | 10.1021/jm950682e | ||
| 119343 | 9649 | 22 | None | -30 | 2 | Human | 5.2 | pA2 | = | 5.2 | Functional | Guide to Pharmacology | None | None | None | None | 9650825 | ||||
| 676 | 9649 | 22 | None | -30 | 2 | Human | 5.2 | pA2 | = | 5.2 | Functional | Guide to Pharmacology | None | None | None | None | 9650825 | ||||
| CHEMBL446325 | 9649 | 22 | None | -30 | 2 | Human | 5.2 | pA2 | = | 5.2 | Functional | Guide to Pharmacology | None | None | None | None | 9650825 | ||||
| 653 | 7353 | 0 | None | 5 | 3 | Human | 8.4 | pA2 | = | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 9650825 | ||||
| 5311108 | 8467 | 18 | None | -9 | 2 | Human | 8.2 | pA2 | = | 8.2 | Functional | Guide to Pharmacology | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 9095082 | ||
| 674 | 8467 | 18 | None | -9 | 2 | Human | 8.2 | pA2 | = | 8.2 | Functional | Guide to Pharmacology | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 9095082 | ||
| CHEMBL130517 | 8467 | 18 | None | -9 | 2 | Human | 8.2 | pA2 | = | 8.2 | Functional | Guide to Pharmacology | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 9095082 | ||
| 667 | 8754 | 37 | None | -2 | 2 | Human | 8.4 | pA2 | = | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 8735629 | ||||
| 6918173 | 8754 | 37 | None | -2 | 2 | Human | 8.4 | pA2 | = | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 8735629 | ||||
| 71364 | 8754 | 37 | None | -2 | 2 | Human | 8.4 | pA2 | = | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 8735629 | ||||
| CHEMBL2028850 | 8754 | 37 | None | -2 | 2 | Human | 8.4 | pA2 | = | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 8735629 | ||||
| DB06196 | 8754 | 37 | None | -2 | 2 | Human | 8.4 | pA2 | = | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 8735629 | ||||
| 5128451 | 8162 | 0 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 646 | 8162 | 0 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 5128451 | 8162 | 0 | None | 1 | 2 | Mouse | 5.2 | pIC50 | = | 5.2 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 646 | 8162 | 0 | None | 1 | 2 | Mouse | 5.2 | pIC50 | = | 5.2 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 672 | 9047 | 21 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | None | None | None | None | 23362191 | ||||
| 6918284 | 9047 | 21 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | None | None | None | None | 23362191 | ||||
| CHEMBL2105864 | 9047 | 21 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | None | None | None | None | 23362191 | ||||
| DB06549 | 9047 | 21 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | None | None | None | None | 23362191 | ||||
| 5311108 | 8467 | 18 | None | -9 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 9203620 | ||
| 674 | 8467 | 18 | None | -9 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 9203620 | ||
| CHEMBL130517 | 8467 | 18 | None | -9 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 9203620 | ||
| 3812 | 7504 | 42 | None | -1 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 3812 | 7504 | 42 | None | -1 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 9203620 | ||||
| 439201 | 7504 | 42 | None | -1 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 439201 | 7504 | 42 | None | -1 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 9203620 | ||||
| 649 | 7504 | 42 | None | -1 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 649 | 7504 | 42 | None | -1 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 9203620 | ||||
| CHEMBL406291 | 7504 | 42 | None | -1 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| CHEMBL406291 | 7504 | 42 | None | -1 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 9203620 | ||||
| DB12126 | 7504 | 42 | None | -1 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| DB12126 | 7504 | 42 | None | -1 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 9203620 | ||||
| 667 | 8754 | 37 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 667 | 8754 | 37 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 9203620 | ||||
| 6918173 | 8754 | 37 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 6918173 | 8754 | 37 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 9203620 | ||||
| 71364 | 8754 | 37 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 71364 | 8754 | 37 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 9203620 | ||||
| CHEMBL2028850 | 8754 | 37 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| CHEMBL2028850 | 8754 | 37 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 9203620 | ||||
| DB06196 | 8754 | 37 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| DB06196 | 8754 | 37 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 9203620 | ||||
| 10255 | 9592 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 19111586 | ||||
| 5311111 | 8956 | 0 | None | -1 | 2 | Mouse | 9.3 | pIC50 | = | 9.3 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 650 | 8956 | 0 | None | -1 | 2 | Mouse | 9.3 | pIC50 | = | 9.3 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 122227 | 8160 | 31 | None | -28840 | 3 | Mouse | 4.6 | pIC50 | None | 4.6 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 3825 | 8160 | 31 | None | -28840 | 3 | Mouse | 4.6 | pIC50 | None | 4.6 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 644 | 8160 | 31 | None | -28840 | 3 | Mouse | 4.6 | pIC50 | None | 4.6 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| CHEMBL264100 | 8160 | 31 | None | -28840 | 3 | Mouse | 4.6 | pIC50 | None | 4.6 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 678 | 10580 | 0 | None | -5 | 2 | Human | 6.3 | pIC50 | None | 6.3 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 119343 | 9649 | 22 | None | -30 | 2 | Human | 6.9 | pIC50 | None | 6.9 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 676 | 9649 | 22 | None | -30 | 2 | Human | 6.9 | pIC50 | None | 6.9 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| CHEMBL446325 | 9649 | 22 | None | -30 | 2 | Human | 6.9 | pIC50 | None | 6.9 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 123973 | 9648 | 0 | None | -79 | 2 | Human | 7.0 | pIC50 | None | 7 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 675 | 9648 | 0 | None | -79 | 2 | Human | 7.0 | pIC50 | None | 7 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 678 | 10580 | 0 | None | 5 | 2 | Mouse | 7.0 | pIC50 | None | 7 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 673 | 8466 | 15 | None | -8 | 2 | Human | 7.2 | pIC50 | None | 7.2 | Functional | Guide to Pharmacology | 671 | 9 | 1 | 6 | 5.8 | O=C(/C=C/c1ccc(cc1)C(=O)N(C)C)NCC(=O)N(c1ccc(c(c1Cl)COc1cccn2c1nc(c2Br)C)Cl)C | 9203620 | ||
| 9810391 | 8466 | 15 | None | -8 | 2 | Human | 7.2 | pIC50 | None | 7.2 | Functional | Guide to Pharmacology | 671 | 9 | 1 | 6 | 5.8 | O=C(/C=C/c1ccc(cc1)C(=O)N(C)C)NCC(=O)N(c1ccc(c(c1Cl)COc1cccn2c1nc(c2Br)C)Cl)C | 9203620 | ||
| CHEMBL1192627 | 8466 | 15 | None | -8 | 2 | Human | 7.2 | pIC50 | None | 7.2 | Functional | Guide to Pharmacology | 671 | 9 | 1 | 6 | 5.8 | O=C(/C=C/c1ccc(cc1)C(=O)N(C)C)NCC(=O)N(c1ccc(c(c1Cl)COc1cccn2c1nc(c2Br)C)Cl)C | 9203620 | ||
| 671 | 10669 | 0 | None | -1 | 2 | Human | 8.0 | pIC50 | None | 8 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 671 | 10669 | 0 | None | 1 | 2 | Mouse | 8.1 | pIC50 | None | 8.1 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 3035449 | 9294 | 0 | None | -1 | 3 | Mouse | 8.4 | pIC50 | None | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 638 | 9294 | 0 | None | -1 | 3 | Mouse | 8.4 | pIC50 | None | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 3035449 | 9294 | 0 | None | 1 | 3 | Human | 8.7 | pIC50 | None | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 638 | 9294 | 0 | None | 1 | 3 | Human | 8.7 | pIC50 | None | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 119343 | 9649 | 22 | None | 30 | 2 | Mouse | 8.7 | pIC50 | None | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 676 | 9649 | 22 | None | 30 | 2 | Mouse | 8.7 | pIC50 | None | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| CHEMBL446325 | 9649 | 22 | None | 30 | 2 | Mouse | 8.7 | pIC50 | None | 8.7 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 123973 | 9648 | 0 | None | 79 | 2 | Mouse | 8.9 | pIC50 | None | 8.9 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 675 | 9648 | 0 | None | 79 | 2 | Mouse | 8.9 | pIC50 | None | 8.9 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 10394861 | 8470 | 5 | None | 9 | 2 | Human | 9.2 | pIC50 | None | 9.2 | Functional | Guide to Pharmacology | 687 | 12 | 2 | 9 | 5.5 | COc1nc2c(n1Cc1ccccn1)cccc2OCc1c(Cl)ccc(c1Cl)N(C(=O)CNC(=O)/C=C/c1ccc(nc1)NC(=O)C)C | 15139763 | ||
| 669 | 8470 | 5 | None | 9 | 2 | Human | 9.2 | pIC50 | None | 9.2 | Functional | Guide to Pharmacology | 687 | 12 | 2 | 9 | 5.5 | COc1nc2c(n1Cc1ccccn1)cccc2OCc1c(Cl)ccc(c1Cl)N(C(=O)CNC(=O)/C=C/c1ccc(nc1)NC(=O)C)C | 15139763 | ||
| CHEMBL329762 | 8470 | 5 | None | 9 | 2 | Human | 9.2 | pIC50 | None | 9.2 | Functional | Guide to Pharmacology | 687 | 12 | 2 | 9 | 5.5 | COc1nc2c(n1Cc1ccccn1)cccc2OCc1c(Cl)ccc(c1Cl)N(C(=O)CNC(=O)/C=C/c1ccc(nc1)NC(=O)C)C | 15139763 | ||
| 3812 | 7504 | 42 | None | 1 | 3 | Mouse | 9.3 | pIC50 | None | 9.3 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 439201 | 7504 | 42 | None | 1 | 3 | Mouse | 9.3 | pIC50 | None | 9.3 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 649 | 7504 | 42 | None | 1 | 3 | Mouse | 9.3 | pIC50 | None | 9.3 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| CHEMBL406291 | 7504 | 42 | None | 1 | 3 | Mouse | 9.3 | pIC50 | None | 9.3 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| DB12126 | 7504 | 42 | None | 1 | 3 | Mouse | 9.3 | pIC50 | None | 9.3 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 5311111 | 8956 | 0 | None | 1 | 2 | Human | 9.3 | pIC50 | None | 9.3 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 650 | 8956 | 0 | None | 1 | 2 | Human | 9.3 | pIC50 | None | 9.3 | Functional | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 11980903 | 21264 | 19 | None | - | 0 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| 22526 | 21264 | 19 | None | - | 0 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| 5281035 | 21264 | 19 | None | - | 0 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1201303 | 21264 | 19 | None | - | 0 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| 137 | 7158 | 52 | None | - | 12 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 249 | 8 | 2 | 3 | 2.2 | C=CCc1ccccc1OCC(CNC(C)C)O | 10.1038/s41467-023-40064-9 | ||
| 2119 | 7158 | 52 | None | - | 12 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 249 | 8 | 2 | 3 | 2.2 | C=CCc1ccccc1OCC(CNC(C)C)O | 10.1038/s41467-023-40064-9 | ||
| 563 | 7158 | 52 | None | - | 12 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 249 | 8 | 2 | 3 | 2.2 | C=CCc1ccccc1OCC(CNC(C)C)O | 10.1038/s41467-023-40064-9 | ||
| 66368 | 7158 | 52 | None | - | 12 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 249 | 8 | 2 | 3 | 2.2 | C=CCc1ccccc1OCC(CNC(C)C)O | 10.1038/s41467-023-40064-9 | ||
| CHEMBL266195 | 7158 | 52 | None | - | 12 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 249 | 8 | 2 | 3 | 2.2 | C=CCc1ccccc1OCC(CNC(C)C)O | 10.1038/s41467-023-40064-9 | ||
| DB00866 | 7158 | 52 | None | - | 12 | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 249 | 8 | 2 | 3 | 2.2 | C=CCc1ccccc1OCC(CNC(C)C)O | 10.1038/s41467-023-40064-9 | ||
| 6436173 | 61890 | 45 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 785 | 2 | 5 | 13 | 6.2 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1617 | 61890 | 45 | None | - | 0 | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 785 | 2 | 5 | 13 | 6.2 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | ||
| 135398735 | 143746 | 32 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 822 | 4 | 6 | 15 | 4.3 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | ||
| 136262914 | 143746 | 32 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 822 | 4 | 6 | 15 | 4.3 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | ||
| CHEMBL374478 | 143746 | 32 | None | - | 0 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 822 | 4 | 6 | 15 | 4.3 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | ||
| 4495 | 203314 | 92 | None | - | 29 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL56367 | 203314 | 92 | None | - | 29 | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | 10.1038/s41467-023-40064-9 | ||
| 5329102 | 201505 | 86 | None | - | 0 | Human | 5.6 | pAC50 | = | 5.6 | Binding | ChEMBL | 398 | 7 | 3 | 3 | 3.3 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | 10.1038/s41467-023-40064-9 | ||
| CHEMBL535 | 201505 | 86 | None | - | 0 | Human | 5.6 | pAC50 | = | 5.6 | Binding | ChEMBL | 398 | 7 | 3 | 3 | 3.3 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | 10.1038/s41467-023-40064-9 | ||
| 135564886 | 21265 | 5 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | ||
| 135673376 | 21265 | 5 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | ||
| 137157436 | 21265 | 5 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | ||
| 145948239 | 21265 | 5 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | ||
| 71587099 | 21265 | 5 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1201304 | 21265 | 5 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | ||
| 26248 | 168318 | 102 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 368 | 3 | 1 | 7 | 2.0 | CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O | 10.1038/s41467-023-40064-9 | ||
| CHEMBL41286 | 168318 | 102 | None | - | 0 | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 368 | 3 | 1 | 7 | 2.0 | CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O | 10.1038/s41467-023-40064-9 | ||
| 2335 | 18620 | 22 | None | - | 12 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | ||
| 8478 | 18620 | 22 | None | - | 12 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1182210 | 18620 | 22 | None | - | 12 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL221753 | 18620 | 22 | None | - | 12 | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | ||
| 41684 | 37995 | 105 | None | - | 0 | Human | 5.3 | pAC50 | = | 5.3 | Binding | ChEMBL | 307 | 4 | 1 | 7 | 2.2 | CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1401 | 37995 | 105 | None | - | 0 | Human | 5.3 | pAC50 | = | 5.3 | Binding | ChEMBL | 307 | 4 | 1 | 7 | 2.2 | CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 | 10.1038/s41467-023-40064-9 | ||
| 2179 | 174297 | 76 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 393 | 5 | 2 | 5 | 4.5 | COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL1256655 | 174297 | 76 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 393 | 5 | 2 | 5 | 4.5 | COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12 | 10.1038/s41467-023-40064-9 | ||
| CHEMBL43 | 174297 | 76 | None | - | 0 | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 393 | 5 | 2 | 5 | 4.5 | COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12 | 10.1038/s41467-023-40064-9 | ||
| 11498853 | 89963 | 13 | None | - | 1 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 763 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL218427 | 89963 | 13 | None | - | 1 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 763 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL541758 | 89963 | 13 | None | - | 1 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 763 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1021/jm9002445 | ||
| 667 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980300f | ||||
| 6918173 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980300f | ||||
| 71364 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980300f | ||||
| CHEMBL2028850 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980300f | ||||
| DB06196 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980300f | ||||
| 667 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980214f | ||||
| 6918173 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980214f | ||||
| 71364 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980214f | ||||
| CHEMBL2028850 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980214f | ||||
| DB06196 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980214f | ||||
| 667 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm030159x | ||||
| 6918173 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm030159x | ||||
| 71364 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm030159x | ||||
| CHEMBL2028850 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm030159x | ||||
| DB06196 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm030159x | ||||
| CHEMBL2370160 | 216581 | 0 | None | - | 0 | Guinea pig | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CS)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1c2ccccc2C[C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm030326t | ||||
| 11801968 | 20483 | 0 | None | - | 0 | Guinea pig | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 617 | 9 | 1 | 6 | 5.7 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1194974 | 20483 | 0 | None | - | 0 | Guinea pig | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 617 | 9 | 1 | 6 | 5.7 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL553614 | 20483 | 0 | None | - | 0 | Guinea pig | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 617 | 9 | 1 | 6 | 5.7 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 11250851 | 20389 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 5.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(-n5cccn5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL1194270 | 20389 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 5.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(-n5cccn5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL3216880 | 20389 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 5.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(-n5cccn5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 9874617 | 20078 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 670 | 10 | 1 | 7 | 6.1 | Cc1cc(-n2cccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL1191908 | 20078 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 670 | 10 | 1 | 7 | 6.1 | Cc1cc(-n2cccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL543070 | 20078 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 670 | 10 | 1 | 7 | 6.1 | Cc1cc(-n2cccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| 11250929 | 20607 | 0 | None | - | 0 | Guinea pig | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 634 | 11 | 2 | 6 | 6.0 | CCOc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/jm030468n | ||
| CHEMBL1195824 | 20607 | 0 | None | - | 0 | Guinea pig | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 634 | 11 | 2 | 6 | 6.0 | CCOc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/jm030468n | ||
| CHEMBL555403 | 20607 | 0 | None | - | 0 | Guinea pig | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 634 | 11 | 2 | 6 | 6.0 | CCOc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/jm030468n | ||
| 11158089 | 19689 | 0 | None | - | 0 | Guinea pig | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 620 | 10 | 2 | 6 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OC)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL1189084 | 19689 | 0 | None | - | 0 | Guinea pig | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 620 | 10 | 2 | 6 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OC)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL538022 | 19689 | 0 | None | - | 0 | Guinea pig | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 620 | 10 | 2 | 6 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OC)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| 18704946 | 19942 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 657 | 10 | 2 | 8 | 5.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(-n5cncn5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL1190879 | 19942 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 657 | 10 | 2 | 8 | 5.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(-n5cncn5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL3217081 | 19942 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 657 | 10 | 2 | 8 | 5.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(-n5cncn5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 44214214 | 20033 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 708 | 10 | 3 | 8 | 7.0 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL1191492 | 20033 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 708 | 10 | 3 | 8 | 7.0 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL542598 | 20033 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 708 | 10 | 3 | 8 | 7.0 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| 44360533 | 19664 | 0 | None | - | 0 | Guinea pig | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 686 | 11 | 1 | 7 | 5.3 | Cc1ccc2cccc(OCc3c(C(=O)N(C)C)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3C(=O)N(C)C)c2n1 | 10.1021/jm980330i | ||
| CHEMBL1188925 | 19664 | 0 | None | - | 0 | Guinea pig | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 686 | 11 | 1 | 7 | 5.3 | Cc1ccc2cccc(OCc3c(C(=O)N(C)C)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3C(=O)N(C)C)c2n1 | 10.1021/jm980330i | ||
| CHEMBL537683 | 19664 | 0 | None | - | 0 | Guinea pig | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 686 | 11 | 1 | 7 | 5.3 | Cc1ccc2cccc(OCc3c(C(=O)N(C)C)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3C(=O)N(C)C)c2n1 | 10.1021/jm980330i | ||
| 10009762 | 19701 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 678 | 10 | 1 | 7 | 7.4 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1016/j.ejmech.2019.07.064 | ||
| CHEMBL1189175 | 19701 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 678 | 10 | 1 | 7 | 7.4 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1016/j.ejmech.2019.07.064 | ||
| CHEMBL3217072 | 19701 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 678 | 10 | 1 | 7 | 7.4 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1016/j.ejmech.2019.07.064 | ||
| 10009762 | 19701 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 678 | 10 | 1 | 7 | 7.4 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL1189175 | 19701 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 678 | 10 | 1 | 7 | 7.4 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL3217072 | 19701 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 678 | 10 | 1 | 7 | 7.4 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| 10627384 | 20510 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 598 | 9 | 2 | 5 | 6.9 | CNC(=O)c1ccc(/C=C/C(=O)NCc2cccn2-c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| CHEMBL1195129 | 20510 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 598 | 9 | 2 | 5 | 6.9 | CNC(=O)c1ccc(/C=C/C(=O)NCc2cccn2-c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| CHEMBL553911 | 20510 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 598 | 9 | 2 | 5 | 6.9 | CNC(=O)c1ccc(/C=C/C(=O)NCc2cccn2-c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| 11490839 | 19941 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 671 | 10 | 1 | 8 | 5.5 | Cc1cc(-n2ccnn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL1190878 | 19941 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 671 | 10 | 1 | 8 | 5.5 | Cc1cc(-n2ccnn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL541805 | 19941 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 671 | 10 | 1 | 8 | 5.5 | Cc1cc(-n2ccnn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| 11273808 | 20570 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 5.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(-n5ccnc5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL1195573 | 20570 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 5.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(-n5ccnc5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL3215979 | 20570 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 5.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(-n5ccnc5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 22008895 | 117335 | 0 | None | - | 1 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 592 | 8 | 1 | 5 | 6.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(F)(F)F)cc4)c3C#N)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL325255 | 117335 | 0 | None | - | 1 | Guinea pig | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 592 | 8 | 1 | 5 | 6.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(F)(F)F)cc4)c3C#N)c2n1 | 10.1021/jm9002445 | ||
| 11445288 | 20648 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 670 | 10 | 1 | 7 | 6.1 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL1196072 | 20648 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 670 | 10 | 1 | 7 | 6.1 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL3217085 | 20648 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 670 | 10 | 1 | 7 | 6.1 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| 11262728 | 145242 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 744 | 13 | 1 | 8 | 8.2 | Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3Cl)c2n1 | 10.1016/j.ejmech.2020.112948 | ||
| CHEMBL3774617 | 145242 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 744 | 13 | 1 | 8 | 8.2 | Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3Cl)c2n1 | 10.1016/j.ejmech.2020.112948 | ||
| 11802489 | 20505 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 658 | 9 | 2 | 7 | 4.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cn1 | 10.1021/jm980214f | ||
| CHEMBL1195106 | 20505 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 658 | 9 | 2 | 7 | 4.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cn1 | 10.1021/jm980214f | ||
| CHEMBL553844 | 20505 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 658 | 9 | 2 | 7 | 4.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cn1 | 10.1021/jm980214f | ||
| 11262728 | 145242 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 744 | 13 | 1 | 8 | 8.2 | Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3Cl)c2n1 | 10.1021/acs.jmedchem.5b00982 | ||
| CHEMBL3774617 | 145242 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 744 | 13 | 1 | 8 | 8.2 | Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3Cl)c2n1 | 10.1021/acs.jmedchem.5b00982 | ||
| 44329173 | 174591 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 787 | 14 | 2 | 9 | 7.4 | Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N/C=C/c5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm030468n | ||
| CHEMBL430652 | 174591 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 787 | 14 | 2 | 9 | 7.4 | Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N/C=C/c5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm030468n | ||
| 44360597 | 20656 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 645 | 11 | 4 | 8 | 5.5 | CC(=O)Nc1ccc(/C=C/C(=O)NCc2cccn2-c2ccc(NC(C)=O)c(COc3cccc4ccc(C)nc34)c2NC(C)=O)cn1 | 10.1021/jm980330i | ||
| CHEMBL1196121 | 20656 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 645 | 11 | 4 | 8 | 5.5 | CC(=O)Nc1ccc(/C=C/C(=O)NCc2cccn2-c2ccc(NC(C)=O)c(COc3cccc4ccc(C)nc34)c2NC(C)=O)cn1 | 10.1021/jm980330i | ||
| CHEMBL555976 | 20656 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 645 | 11 | 4 | 8 | 5.5 | CC(=O)Nc1ccc(/C=C/C(=O)NCc2cccn2-c2ccc(NC(C)=O)c(COc3cccc4ccc(C)nc34)c2NC(C)=O)cn1 | 10.1021/jm980330i | ||
| 10349737 | 19888 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 658 | 9 | 2 | 7 | 5.4 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cn1 | 10.1021/jm980214f | ||
| CHEMBL1190430 | 19888 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 658 | 9 | 2 | 7 | 5.4 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cn1 | 10.1021/jm980214f | ||
| CHEMBL540840 | 19888 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 658 | 9 | 2 | 7 | 5.4 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cn1 | 10.1021/jm980214f | ||
| 11411675 | 103270 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 760 | 13 | 2 | 8 | 7.8 | Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030468n | ||
| CHEMBL262507 | 103270 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 760 | 13 | 2 | 8 | 7.8 | Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030468n | ||
| 5311114 | 8469 | 8 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 697 | 12 | 2 | 7 | 6.6 | CNC(=O)c1ccc(cc1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2OCc1ccccn1)Cl)C | 10.1016/j.ejmech.2020.112948 | ||
| 668 | 8469 | 8 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 697 | 12 | 2 | 7 | 6.6 | CNC(=O)c1ccc(cc1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2OCc1ccccn1)Cl)C | 10.1016/j.ejmech.2020.112948 | ||
| CHEMBL99869 | 8469 | 8 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 697 | 12 | 2 | 7 | 6.6 | CNC(=O)c1ccc(cc1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2OCc1ccccn1)Cl)C | 10.1016/j.ejmech.2020.112948 | ||
| 5311114 | 8469 | 8 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 697 | 12 | 2 | 7 | 6.6 | CNC(=O)c1ccc(cc1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2OCc1ccccn1)Cl)C | 10.1021/acs.jmedchem.5b00982 | ||
| 668 | 8469 | 8 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 697 | 12 | 2 | 7 | 6.6 | CNC(=O)c1ccc(cc1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2OCc1ccccn1)Cl)C | 10.1021/acs.jmedchem.5b00982 | ||
| CHEMBL99869 | 8469 | 8 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 697 | 12 | 2 | 7 | 6.6 | CNC(=O)c1ccc(cc1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2OCc1ccccn1)Cl)C | 10.1021/acs.jmedchem.5b00982 | ||
| 5311114 | 8469 | 8 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 697 | 12 | 2 | 7 | 6.6 | CNC(=O)c1ccc(cc1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2OCc1ccccn1)Cl)C | 10.1021/jm030468n | ||
| 668 | 8469 | 8 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 697 | 12 | 2 | 7 | 6.6 | CNC(=O)c1ccc(cc1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2OCc1ccccn1)Cl)C | 10.1021/jm030468n | ||
| CHEMBL99869 | 8469 | 8 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 697 | 12 | 2 | 7 | 6.6 | CNC(=O)c1ccc(cc1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2OCc1ccccn1)Cl)C | 10.1021/jm030468n | ||
| 44360533 | 19664 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 686 | 11 | 1 | 7 | 5.3 | Cc1ccc2cccc(OCc3c(C(=O)N(C)C)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3C(=O)N(C)C)c2n1 | 10.1021/jm980330i | ||
| CHEMBL1188925 | 19664 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 686 | 11 | 1 | 7 | 5.3 | Cc1ccc2cccc(OCc3c(C(=O)N(C)C)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3C(=O)N(C)C)c2n1 | 10.1021/jm980330i | ||
| CHEMBL537683 | 19664 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 686 | 11 | 1 | 7 | 5.3 | Cc1ccc2cccc(OCc3c(C(=O)N(C)C)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3C(=O)N(C)C)c2n1 | 10.1021/jm980330i | ||
| 44360877 | 20459 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 722 | 11 | 1 | 7 | 6.6 | Cc1ccc2cccc(OCc3c(N4CCCC4=O)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3N3CCCC3=O)c2n1 | 10.1021/jm980330i | ||
| CHEMBL1194797 | 20459 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 722 | 11 | 1 | 7 | 6.6 | Cc1ccc2cccc(OCc3c(N4CCCC4=O)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3N3CCCC3=O)c2n1 | 10.1021/jm980330i | ||
| CHEMBL553315 | 20459 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 722 | 11 | 1 | 7 | 6.6 | Cc1ccc2cccc(OCc3c(N4CCCC4=O)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3N3CCCC3=O)c2n1 | 10.1021/jm980330i | ||
| 11491041 | 20228 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 8 | 7.1 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL1193122 | 20228 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 8 | 7.1 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL544480 | 20228 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 8 | 7.1 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| 11227974 | 20077 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 8.1 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL1191906 | 20077 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 8.1 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL543068 | 20077 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 8.1 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| 10652092 | 19789 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 672 | 9 | 1 | 7 | 5.2 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)nc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1189828 | 19789 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 672 | 9 | 1 | 7 | 5.2 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)nc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL539550 | 19789 | 0 | None | - | 0 | Guinea pig | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 672 | 9 | 1 | 7 | 5.2 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)nc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 5311108 | 8467 | 18 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 10.1021/jm980300f | ||
| 674 | 8467 | 18 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 10.1021/jm980300f | ||
| CHEMBL130517 | 8467 | 18 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 10.1021/jm980300f | ||
| 10531497 | 19985 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1 | 10.1016/j.ejmech.2019.07.064 | ||
| CHEMBL1191172 | 19985 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1 | 10.1016/j.ejmech.2019.07.064 | ||
| CHEMBL542232 | 19985 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1 | 10.1016/j.ejmech.2019.07.064 | ||
| 5311108 | 8467 | 18 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 10.1021/jm980330i | ||
| 674 | 8467 | 18 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 10.1021/jm980330i | ||
| CHEMBL130517 | 8467 | 18 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 10.1021/jm980330i | ||
| 10674687 | 20399 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 576 | 9 | 1 | 5 | 5.7 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3C)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1194363 | 20399 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 576 | 9 | 1 | 5 | 5.7 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3C)c2n1 | 10.1021/jm980300f | ||
| CHEMBL552543 | 20399 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 576 | 9 | 1 | 5 | 5.7 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3C)c2n1 | 10.1021/jm980300f | ||
| 11251046 | 19977 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 696 | 11 | 2 | 7 | 6.9 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1191121 | 19977 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 696 | 11 | 2 | 7 | 6.9 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL542173 | 19977 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 696 | 11 | 2 | 7 | 6.9 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 667 | 8754 | 37 | None | -1 | 6 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm030159x | ||||
| 6918173 | 8754 | 37 | None | -1 | 6 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm030159x | ||||
| 71364 | 8754 | 37 | None | -1 | 6 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm030159x | ||||
| CHEMBL2028850 | 8754 | 37 | None | -1 | 6 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm030159x | ||||
| DB06196 | 8754 | 37 | None | -1 | 6 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm030159x | ||||
| CHEMBL2370160 | 216581 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CS)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1c2ccccc2C[C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm030326t | ||||
| 667 | 8754 | 37 | None | -1 | 6 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980300f | ||||
| 6918173 | 8754 | 37 | None | -1 | 6 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980300f | ||||
| 71364 | 8754 | 37 | None | -1 | 6 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980300f | ||||
| CHEMBL2028850 | 8754 | 37 | None | -1 | 6 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980300f | ||||
| DB06196 | 8754 | 37 | None | -1 | 6 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980300f | ||||
| 11802476 | 19736 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL1189415 | 19736 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL538732 | 19736 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 10698671 | 20240 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 6.2 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL1193229 | 20240 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 6.2 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL544599 | 20240 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 6.2 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 11802476 | 19736 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL1189415 | 19736 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL538732 | 19736 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| 11802476 | 19736 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL1189415 | 19736 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL538732 | 19736 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 10348414 | 175852 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL439737 | 175852 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL542096 | 175852 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 10348414 | 175852 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL439737 | 175852 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL542096 | 175852 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| 10348414 | 175852 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL439737 | 175852 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL542096 | 175852 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 10348414 | 175852 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL439737 | 175852 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL542096 | 175852 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 10348414 | 175852 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| CHEMBL439737 | 175852 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| CHEMBL542096 | 175852 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| 44360968 | 127862 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 775 | 14 | 1 | 8 | 9.0 | Cc1ccc2cccc(OCc3c(/C=C/c4ccncc4)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3/C=C/c3ccncc3)c2n1 | 10.1021/jm980330i | ||
| CHEMBL357075 | 127862 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 775 | 14 | 1 | 8 | 9.0 | Cc1ccc2cccc(OCc3c(/C=C/c4ccncc4)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3/C=C/c3ccncc3)c2n1 | 10.1021/jm980330i | ||
| 10371910 | 26906 | 1 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 637 | 10 | 1 | 6 | 7.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL130436 | 26906 | 1 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 637 | 10 | 1 | 6 | 7.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 11411594 | 19680 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 736 | 11 | 2 | 7 | 7.9 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1189023 | 19680 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 736 | 11 | 2 | 7 | 7.9 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL537927 | 19680 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 736 | 11 | 2 | 7 | 7.9 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 44360818 | 20250 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 783 | 14 | 1 | 8 | 10.3 | Cc1ccc2cccc(OCc3c(/C=C/c4ccncc4)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3/C=C/c3ccncc3)c2n1 | 10.1021/jm980330i | ||
| CHEMBL1193250 | 20250 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 783 | 14 | 1 | 8 | 10.3 | Cc1ccc2cccc(OCc3c(/C=C/c4ccncc4)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3/C=C/c3ccncc3)c2n1 | 10.1021/jm980330i | ||
| CHEMBL544623 | 20250 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 783 | 14 | 1 | 8 | 10.3 | Cc1ccc2cccc(OCc3c(/C=C/c4ccncc4)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3/C=C/c3ccncc3)c2n1 | 10.1021/jm980330i | ||
| 10555818 | 20457 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 616 | 9 | 1 | 5 | 6.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1194778 | 20457 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 616 | 9 | 1 | 5 | 6.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL553293 | 20457 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 616 | 9 | 1 | 5 | 6.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 10675847 | 20189 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 6.0 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL1192831 | 20189 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 6.0 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL544134 | 20189 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 6.0 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| 44361029 | 20138 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 714 | 11 | 1 | 7 | 5.3 | Cc1ccc2cccc(OCc3c(N4CCCC4=O)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3N3CCCC3=O)c2n1 | 10.1021/jm980330i | ||
| CHEMBL1192448 | 20138 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 714 | 11 | 1 | 7 | 5.3 | Cc1ccc2cccc(OCc3c(N4CCCC4=O)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3N3CCCC3=O)c2n1 | 10.1021/jm980330i | ||
| CHEMBL543685 | 20138 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 714 | 11 | 1 | 7 | 5.3 | Cc1ccc2cccc(OCc3c(N4CCCC4=O)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3N3CCCC3=O)c2n1 | 10.1021/jm980330i | ||
| 11479739 | 214982 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 760 | 13 | 2 | 8 | 7.8 | Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030468n | ||
| CHEMBL98460 | 214982 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 760 | 13 | 2 | 8 | 7.8 | Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030468n | ||
| 44360597 | 20656 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 645 | 11 | 4 | 8 | 5.5 | CC(=O)Nc1ccc(/C=C/C(=O)NCc2cccn2-c2ccc(NC(C)=O)c(COc3cccc4ccc(C)nc34)c2NC(C)=O)cn1 | 10.1021/jm980330i | ||
| CHEMBL1196121 | 20656 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 645 | 11 | 4 | 8 | 5.5 | CC(=O)Nc1ccc(/C=C/C(=O)NCc2cccn2-c2ccc(NC(C)=O)c(COc3cccc4ccc(C)nc34)c2NC(C)=O)cn1 | 10.1021/jm980330i | ||
| CHEMBL555976 | 20656 | 0 | None | - | 0 | Guinea pig | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 645 | 11 | 4 | 8 | 5.5 | CC(=O)Nc1ccc(/C=C/C(=O)NCc2cccn2-c2ccc(NC(C)=O)c(COc3cccc4ccc(C)nc34)c2NC(C)=O)cn1 | 10.1021/jm980330i | ||
| 44360877 | 20459 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 722 | 11 | 1 | 7 | 6.6 | Cc1ccc2cccc(OCc3c(N4CCCC4=O)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3N3CCCC3=O)c2n1 | 10.1021/jm980330i | ||
| CHEMBL1194797 | 20459 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 722 | 11 | 1 | 7 | 6.6 | Cc1ccc2cccc(OCc3c(N4CCCC4=O)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3N3CCCC3=O)c2n1 | 10.1021/jm980330i | ||
| CHEMBL553315 | 20459 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 722 | 11 | 1 | 7 | 6.6 | Cc1ccc2cccc(OCc3c(N4CCCC4=O)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3N3CCCC3=O)c2n1 | 10.1021/jm980330i | ||
| 10604613 | 19885 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 683 | 9 | 1 | 6 | 6.2 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1190420 | 19885 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 683 | 9 | 1 | 6 | 6.2 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL540828 | 19885 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 683 | 9 | 1 | 6 | 6.2 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10580156 | 19883 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 653 | 10 | 2 | 6 | 6.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5cccnc5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1190412 | 19883 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 653 | 10 | 2 | 6 | 6.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5cccnc5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL540819 | 19883 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 653 | 10 | 2 | 6 | 6.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5cccnc5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 11239595 | 20495 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 738 | 11 | 2 | 8 | 6.7 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1195041 | 20495 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 738 | 11 | 2 | 8 | 6.7 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL553762 | 20495 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 738 | 11 | 2 | 8 | 6.7 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 10627384 | 20510 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 598 | 9 | 2 | 5 | 6.9 | CNC(=O)c1ccc(/C=C/C(=O)NCc2cccn2-c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| CHEMBL1195129 | 20510 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 598 | 9 | 2 | 5 | 6.9 | CNC(=O)c1ccc(/C=C/C(=O)NCc2cccn2-c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| CHEMBL553911 | 20510 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 598 | 9 | 2 | 5 | 6.9 | CNC(=O)c1ccc(/C=C/C(=O)NCc2cccn2-c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| 10675243 | 103555 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 610 | 10 | 2 | 8 | 4.6 | COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc2n1C | 10.1021/jm980300f | ||
| CHEMBL264751 | 103555 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 610 | 10 | 2 | 8 | 4.6 | COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc2n1C | 10.1021/jm980300f | ||
| 10675243 | 103555 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 610 | 10 | 2 | 8 | 4.6 | COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc2n1C | 10.1021/jm030468n | ||
| CHEMBL264751 | 103555 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 610 | 10 | 2 | 8 | 4.6 | COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc2n1C | 10.1021/jm030468n | ||
| 673 | 8466 | 15 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 5.8 | O=C(/C=C/c1ccc(cc1)C(=O)N(C)C)NCC(=O)N(c1ccc(c(c1Cl)COc1cccn2c1nc(c2Br)C)Cl)C | 10.1021/jm980300f | ||
| 9810391 | 8466 | 15 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 5.8 | O=C(/C=C/c1ccc(cc1)C(=O)N(C)C)NCC(=O)N(c1ccc(c(c1Cl)COc1cccn2c1nc(c2Br)C)Cl)C | 10.1021/jm980300f | ||
| CHEMBL1192627 | 8466 | 15 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 5.8 | O=C(/C=C/c1ccc(cc1)C(=O)N(C)C)NCC(=O)N(c1ccc(c(c1Cl)COc1cccn2c1nc(c2Br)C)Cl)C | 10.1021/jm980300f | ||
| 673 | 8466 | 15 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 5.8 | O=C(/C=C/c1ccc(cc1)C(=O)N(C)C)NCC(=O)N(c1ccc(c(c1Cl)COc1cccn2c1nc(c2Br)C)Cl)C | 10.1021/jm980214f | ||
| 9810391 | 8466 | 15 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 5.8 | O=C(/C=C/c1ccc(cc1)C(=O)N(C)C)NCC(=O)N(c1ccc(c(c1Cl)COc1cccn2c1nc(c2Br)C)Cl)C | 10.1021/jm980214f | ||
| CHEMBL1192627 | 8466 | 15 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 5.8 | O=C(/C=C/c1ccc(cc1)C(=O)N(C)C)NCC(=O)N(c1ccc(c(c1Cl)COc1cccn2c1nc(c2Br)C)Cl)C | 10.1021/jm980214f | ||
| 45269613 | 201633 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 695 | 12 | 3 | 7 | 6.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)N4CCC[C@H]4C(=O)CCCNC(=O)c4ccc(C(=N)N)cc4)c3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL539924 | 201633 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 695 | 12 | 3 | 7 | 6.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)N4CCC[C@H]4C(=O)CCCNC(=O)c4ccc(C(=N)N)cc4)c3Cl)c2n1 | 10.1021/jm9002445 | ||
| 10531497 | 19985 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1 | 10.1021/jm980300f | ||
| CHEMBL1191172 | 19985 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1 | 10.1021/jm980300f | ||
| CHEMBL542232 | 19985 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1 | 10.1021/jm980300f | ||
| 10394861 | 8470 | 5 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 687 | 12 | 2 | 9 | 5.5 | COc1nc2c(n1Cc1ccccn1)cccc2OCc1c(Cl)ccc(c1Cl)N(C(=O)CNC(=O)/C=C/c1ccc(nc1)NC(=O)C)C | 10.1021/jm030468n | ||
| 669 | 8470 | 5 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 687 | 12 | 2 | 9 | 5.5 | COc1nc2c(n1Cc1ccccn1)cccc2OCc1c(Cl)ccc(c1Cl)N(C(=O)CNC(=O)/C=C/c1ccc(nc1)NC(=O)C)C | 10.1021/jm030468n | ||
| CHEMBL329762 | 8470 | 5 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 687 | 12 | 2 | 9 | 5.5 | COc1nc2c(n1Cc1ccccn1)cccc2OCc1c(Cl)ccc(c1Cl)N(C(=O)CNC(=O)/C=C/c1ccc(nc1)NC(=O)C)C | 10.1021/jm030468n | ||
| 44360879 | 19743 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 637 | 11 | 4 | 8 | 2.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C(=O)NC)c(COc3cccc4ccc(C)nc34)c2C(=O)NC)cn1 | 10.1021/jm980330i | ||
| CHEMBL1189464 | 19743 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 637 | 11 | 4 | 8 | 2.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C(=O)NC)c(COc3cccc4ccc(C)nc34)c2C(=O)NC)cn1 | 10.1021/jm980330i | ||
| CHEMBL538784 | 19743 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 637 | 11 | 4 | 8 | 2.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C(=O)NC)c(COc3cccc4ccc(C)nc34)c2C(=O)NC)cn1 | 10.1021/jm980330i | ||
| 10394861 | 8470 | 5 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 687 | 12 | 2 | 9 | 5.5 | COc1nc2c(n1Cc1ccccn1)cccc2OCc1c(Cl)ccc(c1Cl)N(C(=O)CNC(=O)/C=C/c1ccc(nc1)NC(=O)C)C | 10.1016/j.ejmech.2020.112948 | ||
| 669 | 8470 | 5 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 687 | 12 | 2 | 9 | 5.5 | COc1nc2c(n1Cc1ccccn1)cccc2OCc1c(Cl)ccc(c1Cl)N(C(=O)CNC(=O)/C=C/c1ccc(nc1)NC(=O)C)C | 10.1016/j.ejmech.2020.112948 | ||
| CHEMBL329762 | 8470 | 5 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 687 | 12 | 2 | 9 | 5.5 | COc1nc2c(n1Cc1ccccn1)cccc2OCc1c(Cl)ccc(c1Cl)N(C(=O)CNC(=O)/C=C/c1ccc(nc1)NC(=O)C)C | 10.1016/j.ejmech.2020.112948 | ||
| 9958759 | 20243 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 533 | 8 | 1 | 4 | 6.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccccc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1193231 | 20243 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 533 | 8 | 1 | 4 | 6.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccccc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL544601 | 20243 | 0 | None | - | 0 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 533 | 8 | 1 | 4 | 6.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccccc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 11445540 | 174952 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 727 | 13 | 2 | 8 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OCc5ccccn5)cc(C)nc34)c2Cl)cc1OC | 10.1021/jm030468n | ||
| CHEMBL433214 | 174952 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 727 | 13 | 2 | 8 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OCc5ccccn5)cc(C)nc34)c2Cl)cc1OC | 10.1021/jm030468n | ||
| 10032884 | 20237 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 696 | 11 | 2 | 7 | 6.9 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1193185 | 20237 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 696 | 11 | 2 | 7 | 6.9 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL544549 | 20237 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 696 | 11 | 2 | 7 | 6.9 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 10257108 | 16603 | 1 | None | - | 1 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 554 | 9 | 1 | 6 | 5.4 | COc1cccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2C#N)c1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113963 | 16603 | 1 | None | - | 1 | Guinea pig | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 554 | 9 | 1 | 6 | 5.4 | COc1cccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2C#N)c1 | 10.1016/s0960-894x(98)00736-7 | ||
| 10371910 | 26906 | 1 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 637 | 10 | 1 | 6 | 7.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL130436 | 26906 | 1 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 637 | 10 | 1 | 6 | 7.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 10651980 | 20190 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 660 | 8 | 2 | 6 | 5.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C(=O)N(C)C)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1192832 | 20190 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 660 | 8 | 2 | 6 | 5.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C(=O)N(C)C)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL544135 | 20190 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 660 | 8 | 2 | 6 | 5.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C(=O)N(C)C)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 11365972 | 20415 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 687 | 10 | 1 | 6 | 6.9 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1194477 | 20415 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 687 | 10 | 1 | 6 | 6.9 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL3216391 | 20415 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 687 | 10 | 1 | 6 | 6.9 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 44360968 | 127862 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 775 | 14 | 1 | 8 | 9.0 | Cc1ccc2cccc(OCc3c(/C=C/c4ccncc4)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3/C=C/c3ccncc3)c2n1 | 10.1021/jm980330i | ||
| CHEMBL357075 | 127862 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 775 | 14 | 1 | 8 | 9.0 | Cc1ccc2cccc(OCc3c(/C=C/c4ccncc4)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3/C=C/c3ccncc3)c2n1 | 10.1021/jm980330i | ||
| 44353012 | 20161 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 600 | 8 | 1 | 5 | 6.1 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C\c4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1192626 | 20161 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 600 | 8 | 1 | 5 | 6.1 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C\c4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL543898 | 20161 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 600 | 8 | 1 | 5 | 6.1 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C\c4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10721082 | 20067 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 534 | 8 | 1 | 5 | 5.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4cccnc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1191809 | 20067 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 534 | 8 | 1 | 5 | 5.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4cccnc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL542958 | 20067 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 534 | 8 | 1 | 5 | 5.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4cccnc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 10818426 | 20133 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 690 | 11 | 3 | 7 | 5.5 | COCCNC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL1192425 | 20133 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 690 | 11 | 3 | 7 | 5.5 | COCCNC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL543657 | 20133 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 690 | 11 | 3 | 7 | 5.5 | COCCNC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| 10746610 | 20188 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 631 | 8 | 2 | 6 | 6.3 | CC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL1192829 | 20188 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 631 | 8 | 2 | 6 | 6.3 | CC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL544132 | 20188 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 631 | 8 | 2 | 6 | 6.3 | CC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| 10578612 | 20504 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 551 | 9 | 2 | 6 | 4.9 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| CHEMBL1195105 | 20504 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 551 | 9 | 2 | 6 | 4.9 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| CHEMBL553843 | 20504 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 551 | 9 | 2 | 6 | 4.9 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| 10722424 | 177738 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 609 | 10 | 2 | 7 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(OC)n4C)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL44557 | 177738 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 609 | 10 | 2 | 7 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(OC)n4C)c2Cl)cc1 | 10.1021/jm980300f | ||
| 10722424 | 177738 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 609 | 10 | 2 | 7 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(OC)n4C)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL44557 | 177738 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 609 | 10 | 2 | 7 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(OC)n4C)c2Cl)cc1 | 10.1021/jm030159x | ||
| 11491055 | 214980 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 723 | 12 | 1 | 7 | 7.3 | Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm030468n | ||
| CHEMBL98459 | 214980 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 723 | 12 | 1 | 7 | 7.3 | Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm030468n | ||
| 44360553 | 20578 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 645 | 11 | 4 | 8 | 3.7 | CNC(=O)c1ccc(/C=C/C(=O)NCc2cccn2-c2ccc(C(=O)NC)c(COc3cccc4ccc(C)nc34)c2C(=O)NC)cn1 | 10.1021/jm980330i | ||
| CHEMBL1195619 | 20578 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 645 | 11 | 4 | 8 | 3.7 | CNC(=O)c1ccc(/C=C/C(=O)NCc2cccn2-c2ccc(C(=O)NC)c(COc3cccc4ccc(C)nc34)c2C(=O)NC)cn1 | 10.1021/jm980330i | ||
| CHEMBL555006 | 20578 | 0 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 645 | 11 | 4 | 8 | 3.7 | CNC(=O)c1ccc(/C=C/C(=O)NCc2cccn2-c2ccc(C(=O)NC)c(COc3cccc4ccc(C)nc34)c2C(=O)NC)cn1 | 10.1021/jm980330i | ||
| 11377448 | 19827 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 689 | 10 | 1 | 7 | 5.8 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1190058 | 19827 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 689 | 10 | 1 | 7 | 5.8 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL3216622 | 19827 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 689 | 10 | 1 | 7 | 5.8 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 10842202 | 20618 | 1 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 672 | 9 | 3 | 6 | 5.8 | CNC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL1195903 | 20618 | 1 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 672 | 9 | 3 | 6 | 5.8 | CNC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL555555 | 20618 | 1 | None | - | 0 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 672 | 9 | 3 | 6 | 5.8 | CNC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| 9831859 | 16478 | 0 | None | - | 1 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 508 | 10 | 3 | 6 | 3.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCCCCN)c3C#N)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113169 | 16478 | 0 | None | - | 1 | Guinea pig | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 508 | 10 | 3 | 6 | 3.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCCCCN)c3C#N)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| 11422541 | 214946 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 682 | 13 | 2 | 10 | 4.6 | CCOC(=O)Cn1c(OC)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc21 | 10.1021/jm030468n | ||
| CHEMBL98292 | 214946 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 682 | 13 | 2 | 10 | 4.6 | CCOC(=O)Cn1c(OC)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc21 | 10.1021/jm030468n | ||
| 10627732 | 29239 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 623 | 10 | 1 | 7 | 5.0 | COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)cccc2n1C | 10.1021/jm980300f | ||
| CHEMBL132510 | 29239 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 623 | 10 | 1 | 7 | 5.0 | COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)cccc2n1C | 10.1021/jm980300f | ||
| 10769383 | 29637 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 570 | 10 | 2 | 8 | 3.9 | COc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3C)cccc2n1C | 10.1021/jm980300f | ||
| CHEMBL132860 | 29637 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 570 | 10 | 2 | 8 | 3.9 | COc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3C)cccc2n1C | 10.1021/jm980300f | ||
| 10745254 | 42101 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 550 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980300f | ||
| CHEMBL143697 | 42101 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 550 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980300f | ||
| CHEMBL543781 | 42101 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 550 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980300f | ||
| 10745254 | 42101 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 550 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL143697 | 42101 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 550 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL543781 | 42101 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 550 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm030159x | ||
| 10745254 | 42101 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 550 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980330i | ||
| CHEMBL143697 | 42101 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 550 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980330i | ||
| CHEMBL543781 | 42101 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 550 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980330i | ||
| 10579332 | 20526 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL1195281 | 20526 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL554206 | 20526 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 10579332 | 20526 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL1195281 | 20526 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL554206 | 20526 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 11239019 | 20259 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 626 | 10 | 2 | 5 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c(-c5ccccc5)cc(C)nc34)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL1193332 | 20259 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 626 | 10 | 2 | 5 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c(-c5ccccc5)cc(C)nc34)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL544720 | 20259 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 626 | 10 | 2 | 5 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c(-c5ccccc5)cc(C)nc34)c2C)cc1 | 10.1021/jm030159x | ||
| 11468276 | 20285 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 738 | 11 | 2 | 8 | 6.7 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1193590 | 20285 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 738 | 11 | 2 | 8 | 6.7 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL545021 | 20285 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 738 | 11 | 2 | 8 | 6.7 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 10651897 | 19773 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 653 | 10 | 2 | 6 | 6.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1189702 | 19773 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 653 | 10 | 2 | 6 | 6.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL539294 | 19773 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 653 | 10 | 2 | 6 | 6.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 10841531 | 27330 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 617 | 9 | 1 | 6 | 5.7 | Cc1cnc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL130782 | 27330 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 617 | 9 | 1 | 6 | 5.7 | Cc1cnc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 11801800 | 27932 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 604 | 9 | 1 | 5 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4cccc(C(=O)N(C)C)c4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL131263 | 27932 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 604 | 9 | 1 | 5 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4cccc(C(=O)N(C)C)c4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 10699672 | 19729 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 6.1 | CC(=O)N(C)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL1189342 | 19729 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 6.1 | CC(=O)N(C)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL538531 | 19729 | 0 | None | - | 0 | Guinea pig | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 6.1 | CC(=O)N(C)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| 10348414 | 175852 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/acs.jmedchem.5b00982 | ||
| CHEMBL439737 | 175852 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/acs.jmedchem.5b00982 | ||
| CHEMBL542096 | 175852 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/acs.jmedchem.5b00982 | ||
| 10348414 | 175852 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL439737 | 175852 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL542096 | 175852 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 10348414 | 175852 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL439737 | 175852 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL542096 | 175852 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| 11456652 | 19979 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 676 | 10 | 2 | 8 | 4.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCOCC5)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| CHEMBL1191124 | 19979 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 676 | 10 | 2 | 8 | 4.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCOCC5)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| CHEMBL542176 | 19979 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 676 | 10 | 2 | 8 | 4.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCOCC5)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| 11468051 | 20462 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 673 | 10 | 2 | 6 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL1194820 | 20462 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 673 | 10 | 2 | 6 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL3215558 | 20462 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 673 | 10 | 2 | 6 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 10348414 | 175852 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL439737 | 175852 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL542096 | 175852 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 10348414 | 175852 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| CHEMBL439737 | 175852 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| CHEMBL542096 | 175852 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| 10348414 | 175852 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL439737 | 175852 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL542096 | 175852 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 11216111 | 20062 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 648 | 12 | 2 | 6 | 6.4 | CCCOc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/jm030468n | ||
| CHEMBL1191769 | 20062 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 648 | 12 | 2 | 6 | 6.4 | CCCOc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/jm030468n | ||
| CHEMBL542911 | 20062 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 648 | 12 | 2 | 6 | 6.4 | CCCOc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/jm030468n | ||
| 11169915 | 20311 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 648 | 11 | 2 | 6 | 6.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OC(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL1193789 | 20311 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 648 | 11 | 2 | 6 | 6.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OC(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL545255 | 20311 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 648 | 11 | 2 | 6 | 6.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OC(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| 11169975 | 214979 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 698 | 12 | 2 | 8 | 6.5 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OCc5ccccn5)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030468n | ||
| CHEMBL98458 | 214979 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 698 | 12 | 2 | 8 | 6.5 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OCc5ccccn5)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030468n | ||
| 11169975 | 214979 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 698 | 12 | 2 | 8 | 6.5 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OCc5ccccn5)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030468n | ||
| CHEMBL98458 | 214979 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 698 | 12 | 2 | 8 | 6.5 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OCc5ccccn5)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030468n | ||
| 11445066 | 20183 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 634 | 10 | 2 | 7 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| CHEMBL1192789 | 20183 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 634 | 10 | 2 | 7 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| CHEMBL544087 | 20183 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 634 | 10 | 2 | 7 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| 11456756 | 20581 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 699 | 10 | 1 | 6 | 7.3 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1195624 | 20581 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 699 | 10 | 1 | 6 | 7.3 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL3216405 | 20581 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 699 | 10 | 1 | 6 | 7.3 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 22008895 | 117335 | 0 | None | - | 1 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 592 | 8 | 1 | 5 | 6.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(F)(F)F)cc4)c3C#N)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL325255 | 117335 | 0 | None | - | 1 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 592 | 8 | 1 | 5 | 6.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(F)(F)F)cc4)c3C#N)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| 10603710 | 20433 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 604 | 9 | 1 | 5 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1194615 | 20433 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 604 | 9 | 1 | 5 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL552986 | 20433 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 604 | 9 | 1 | 5 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 10348414 | 175852 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL439737 | 175852 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL542096 | 175852 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 10603710 | 20433 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 604 | 9 | 1 | 5 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL1194615 | 20433 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 604 | 9 | 1 | 5 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL552986 | 20433 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 604 | 9 | 1 | 5 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| 44360617 | 20249 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 678 | 11 | 1 | 7 | 4.0 | Cc1ccc2cccc(OCc3c(C(=O)N(C)C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3C(=O)N(C)C)c2n1 | 10.1021/jm980330i | ||
| CHEMBL1193249 | 20249 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 678 | 11 | 1 | 7 | 4.0 | Cc1ccc2cccc(OCc3c(C(=O)N(C)C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3C(=O)N(C)C)c2n1 | 10.1021/jm980330i | ||
| CHEMBL544622 | 20249 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 678 | 11 | 1 | 7 | 4.0 | Cc1ccc2cccc(OCc3c(C(=O)N(C)C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3C(=O)N(C)C)c2n1 | 10.1021/jm980330i | ||
| 10555195 | 20016 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 577 | 9 | 1 | 6 | 5.1 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)nc4)c3C)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1191388 | 20016 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 577 | 9 | 1 | 6 | 5.1 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)nc4)c3C)c2n1 | 10.1021/jm980300f | ||
| CHEMBL542479 | 20016 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 577 | 9 | 1 | 6 | 5.1 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)nc4)c3C)c2n1 | 10.1021/jm980300f | ||
| 673 | 8466 | 15 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 5.8 | O=C(/C=C/c1ccc(cc1)C(=O)N(C)C)NCC(=O)N(c1ccc(c(c1Cl)COc1cccn2c1nc(c2Br)C)Cl)C | 10.1021/jm980300f | ||
| 9810391 | 8466 | 15 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 5.8 | O=C(/C=C/c1ccc(cc1)C(=O)N(C)C)NCC(=O)N(c1ccc(c(c1Cl)COc1cccn2c1nc(c2Br)C)Cl)C | 10.1021/jm980300f | ||
| CHEMBL1192627 | 8466 | 15 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 5.8 | O=C(/C=C/c1ccc(cc1)C(=O)N(C)C)NCC(=O)N(c1ccc(c(c1Cl)COc1cccn2c1nc(c2Br)C)Cl)C | 10.1021/jm980300f | ||
| 11801941 | 20619 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 614 | 7 | 2 | 6 | 5.9 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C#N)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1195904 | 20619 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 614 | 7 | 2 | 6 | 5.9 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C#N)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL555556 | 20619 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 614 | 7 | 2 | 6 | 5.9 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C#N)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10698666 | 20779 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 589 | 7 | 2 | 5 | 6.1 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1197062 | 20779 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 589 | 7 | 2 | 5 | 6.1 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL559195 | 20779 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 589 | 7 | 2 | 5 | 6.1 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10627456 | 26922 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 602 | 9 | 1 | 5 | 6.0 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)CCc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL130452 | 26922 | 0 | None | - | 0 | Guinea pig | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 602 | 9 | 1 | 5 | 6.0 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)CCc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 673 | 8466 | 15 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 5.8 | O=C(/C=C/c1ccc(cc1)C(=O)N(C)C)NCC(=O)N(c1ccc(c(c1Cl)COc1cccn2c1nc(c2Br)C)Cl)C | 10.1021/jm980214f | ||
| 9810391 | 8466 | 15 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 5.8 | O=C(/C=C/c1ccc(cc1)C(=O)N(C)C)NCC(=O)N(c1ccc(c(c1Cl)COc1cccn2c1nc(c2Br)C)Cl)C | 10.1021/jm980214f | ||
| CHEMBL1192627 | 8466 | 15 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 5.8 | O=C(/C=C/c1ccc(cc1)C(=O)N(C)C)NCC(=O)N(c1ccc(c(c1Cl)COc1cccn2c1nc(c2Br)C)Cl)C | 10.1021/jm980214f | ||
| 5311108 | 8467 | 18 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 10.1021/jm9002445 | ||
| 674 | 8467 | 18 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 10.1021/jm9002445 | ||
| CHEMBL130517 | 8467 | 18 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 10.1021/jm9002445 | ||
| 11204833 | 118410 | 1 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 711 | 12 | 1 | 7 | 6.9 | Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030468n | ||
| CHEMBL328509 | 118410 | 1 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 711 | 12 | 1 | 7 | 6.9 | Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030468n | ||
| 11433973 | 119172 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 698 | 12 | 2 | 8 | 6.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OCc5ccccn5)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030468n | ||
| CHEMBL329701 | 119172 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 698 | 12 | 2 | 8 | 6.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OCc5ccccn5)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030468n | ||
| 5311108 | 8467 | 18 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 10.1021/jm980330i | ||
| 674 | 8467 | 18 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 10.1021/jm980330i | ||
| CHEMBL130517 | 8467 | 18 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 10.1021/jm980330i | ||
| 5311108 | 8467 | 18 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 10.1021/jm980300f | ||
| 674 | 8467 | 18 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 10.1021/jm980300f | ||
| CHEMBL130517 | 8467 | 18 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(cn1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2)Cl)C | 10.1021/jm980300f | ||
| 11802476 | 19736 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL1189415 | 19736 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL538732 | 19736 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 11802476 | 19736 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL1189415 | 19736 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL538732 | 19736 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| 44360553 | 20578 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 645 | 11 | 4 | 8 | 3.7 | CNC(=O)c1ccc(/C=C/C(=O)NCc2cccn2-c2ccc(C(=O)NC)c(COc3cccc4ccc(C)nc34)c2C(=O)NC)cn1 | 10.1021/jm980330i | ||
| CHEMBL1195619 | 20578 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 645 | 11 | 4 | 8 | 3.7 | CNC(=O)c1ccc(/C=C/C(=O)NCc2cccn2-c2ccc(C(=O)NC)c(COc3cccc4ccc(C)nc34)c2C(=O)NC)cn1 | 10.1021/jm980330i | ||
| CHEMBL555006 | 20578 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 645 | 11 | 4 | 8 | 3.7 | CNC(=O)c1ccc(/C=C/C(=O)NCc2cccn2-c2ccc(C(=O)NC)c(COc3cccc4ccc(C)nc34)c2C(=O)NC)cn1 | 10.1021/jm980330i | ||
| 10721752 | 175997 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 569 | 10 | 2 | 7 | 3.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(OC)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| CHEMBL44087 | 175997 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 569 | 10 | 2 | 7 | 3.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(OC)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| 10675847 | 20189 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 6.0 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL1192831 | 20189 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 6.0 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL544134 | 20189 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 6.0 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| 10721752 | 175997 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 569 | 10 | 2 | 7 | 3.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(OC)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL44087 | 175997 | 0 | None | - | 0 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 569 | 10 | 2 | 7 | 3.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(OC)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| 11308648 | 19807 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 736 | 11 | 2 | 7 | 7.9 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1189935 | 19807 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 736 | 11 | 2 | 7 | 7.9 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL539792 | 19807 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 736 | 11 | 2 | 7 | 7.9 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 11445066 | 20183 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 634 | 10 | 2 | 7 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| CHEMBL1192789 | 20183 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 634 | 10 | 2 | 7 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| CHEMBL544087 | 20183 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 634 | 10 | 2 | 7 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| 122189857 | 130192 | 0 | None | - | 2 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 1742 | 42 | 23 | 22 | -4.6 | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)CC1C(=O)NCC(=O)NC(Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1C(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)CC2CCCCC21 | 10.1016/j.bmcl.2015.08.014 | ||
| CHEMBL3616881 | 130192 | 0 | None | - | 2 | Guinea pig | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 1742 | 42 | 23 | 22 | -4.6 | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)CC1C(=O)NCC(=O)NC(Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1C(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)CC2CCCCC21 | 10.1016/j.bmcl.2015.08.014 | ||
| 122189855 | 130190 | 0 | None | - | 3 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1816 | 45 | 23 | 23 | -3.5 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)CC1C(=O)NCC(=O)NC(Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1C(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)CC2CCCCC21 | 10.1016/j.bmcl.2015.08.014 | ||
| CHEMBL3616879 | 130190 | 0 | None | - | 3 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1816 | 45 | 23 | 23 | -3.5 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)CC1C(=O)NCC(=O)NC(Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1C(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)CC2CCCCC21 | 10.1016/j.bmcl.2015.08.014 | ||
| 3812 | 7504 | 42 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2013.01.025 | ||||
| 439201 | 7504 | 42 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2013.01.025 | ||||
| 649 | 7504 | 42 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2013.01.025 | ||||
| CHEMBL406291 | 7504 | 42 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2013.01.025 | ||||
| DB12126 | 7504 | 42 | None | 1 | 6 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2013.01.025 | ||||
| 11399463 | 20229 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 633 | 10 | 2 | 6 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL1193123 | 20229 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 633 | 10 | 2 | 6 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL3143949 | 20229 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 633 | 10 | 2 | 6 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 11399463 | 20229 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 633 | 10 | 2 | 6 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL1193123 | 20229 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 633 | 10 | 2 | 6 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL3143949 | 20229 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 633 | 10 | 2 | 6 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 11445445 | 20490 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 701 | 10 | 1 | 7 | 6.2 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1195018 | 20490 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 701 | 10 | 1 | 7 | 6.2 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL3215999 | 20490 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 701 | 10 | 1 | 7 | 6.2 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 11204664 | 118350 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 676 | 10 | 2 | 8 | 5.4 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCOCC5)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| CHEMBL328131 | 118350 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 676 | 10 | 2 | 8 | 5.4 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCOCC5)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| 10651897 | 19773 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 653 | 10 | 2 | 6 | 6.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1189702 | 19773 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 653 | 10 | 2 | 6 | 6.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL539294 | 19773 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 653 | 10 | 2 | 6 | 6.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 122189856 | 130191 | 0 | None | - | 1 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1858 | 43 | 22 | 22 | -2.5 | N=C(N)NCCC[C@H](NC(=O)C1CC2CCCCC2N1C(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](CO)NC(=O)C(Cc1cccs1)NC(=O)CNC(=O)C1CC(O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O | 10.1016/j.bmcl.2015.08.014 | ||
| CHEMBL3616880 | 130191 | 0 | None | - | 1 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1858 | 43 | 22 | 22 | -2.5 | N=C(N)NCCC[C@H](NC(=O)C1CC2CCCCC2N1C(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](CO)NC(=O)C(Cc1cccs1)NC(=O)CNC(=O)C1CC(O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O | 10.1016/j.bmcl.2015.08.014 | ||
| 10531744 | 123121 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 605 | 9 | 1 | 6 | 5.3 | Cc1cnc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL335946 | 123121 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 605 | 9 | 1 | 6 | 5.3 | Cc1cnc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 10698671 | 20240 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 6.2 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL1193229 | 20240 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 6.2 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL544599 | 20240 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 590 | 9 | 2 | 5 | 6.2 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 119343 | 9649 | 22 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2013.03.016 | ||||
| 676 | 9649 | 22 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2013.03.016 | ||||
| CHEMBL446325 | 9649 | 22 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2013.03.016 | ||||
| 45272156 | 201838 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 556 | 6 | 0 | 7 | 6.8 | Cc1cc(-c2ncsc2Cl)c2cccc(OCc3c(C)ccnc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL549534 | 201838 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 556 | 6 | 0 | 7 | 6.8 | Cc1cc(-c2ncsc2Cl)c2cccc(OCc3c(C)ccnc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | 10.1021/jm9002445 | ||
| 44190263 | 202733 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 483 | 7 | 1 | 6 | 5.4 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(C)ccnc3CNC(=O)C3CCCCC3)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL559565 | 202733 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 483 | 7 | 1 | 6 | 5.4 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(C)ccnc3CNC(=O)C3CCCCC3)c2n1 | 10.1021/jm9002445 | ||
| 18941145 | 16735 | 0 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 569 | 9 | 1 | 6 | 6.3 | COc1cccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4sc(C)nc34)c2Cl)c1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL114732 | 16735 | 0 | None | - | 1 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 569 | 9 | 1 | 6 | 6.3 | COc1cccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4sc(C)nc34)c2Cl)c1 | 10.1016/s0960-894x(98)00736-7 | ||
| 10627129 | 108323 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 583 | 11 | 2 | 7 | 4.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(COC)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| CHEMBL298320 | 108323 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 583 | 11 | 2 | 7 | 4.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(COC)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| 10627129 | 108323 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 583 | 11 | 2 | 7 | 4.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(COC)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL298320 | 108323 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 583 | 11 | 2 | 7 | 4.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(COC)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| 10663541 | 126300 | 1 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 320 | 4 | 0 | 3 | 4.8 | CCc1cn2cccc(OCc3c(Cl)cccc3Cl)c2n1 | 10.1021/jm970591c | ||
| CHEMBL345670 | 126300 | 1 | None | - | 0 | Guinea pig | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 320 | 4 | 0 | 3 | 4.8 | CCc1cn2cccc(OCc3c(Cl)cccc3Cl)c2n1 | 10.1021/jm970591c | ||
| 10818058 | 123362 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 653 | 10 | 2 | 6 | 6.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL336574 | 123362 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 653 | 10 | 2 | 6 | 6.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 10579547 | 20348 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 603 | 8 | 2 | 5 | 5.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1194034 | 20348 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 603 | 8 | 2 | 5 | 5.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL545534 | 20348 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 603 | 8 | 2 | 5 | 5.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10556247 | 29800 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 652 | 10 | 2 | 5 | 7.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccccc5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL133005 | 29800 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 652 | 10 | 2 | 5 | 7.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccccc5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 44341039 | 16283 | 0 | None | - | 1 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 597 | 9 | 1 | 5 | 6.6 | COc1ccc(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)c(Cl)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL112140 | 16283 | 0 | None | - | 1 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 597 | 9 | 1 | 5 | 6.6 | COc1ccc(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)c(Cl)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| 22008892 | 116939 | 0 | None | - | 1 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 561 | 8 | 1 | 4 | 6.6 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(F)(F)F)cc4)c3C)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL323693 | 116939 | 0 | None | - | 1 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 561 | 8 | 1 | 4 | 6.6 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(F)(F)F)cc4)c3C)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| 10651074 | 108338 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4cnc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL298463 | 108338 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4cnc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 44189789 | 202932 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 398 | 4 | 1 | 4 | 5.5 | Cc1cc(-c2n[nH]cc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL561223 | 202932 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 398 | 4 | 1 | 4 | 5.5 | Cc1cc(-c2n[nH]cc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44190166 | 203413 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 415 | 4 | 0 | 5 | 6.3 | Cc1cc(-c2scnc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL564294 | 203413 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 415 | 4 | 0 | 5 | 6.3 | Cc1cc(-c2scnc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 10651074 | 108338 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4cnc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL298463 | 108338 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4cnc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 10626618 | 40249 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 556 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2)cc1 | 10.1021/jm980330i | ||
| CHEMBL142015 | 40249 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 556 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2)cc1 | 10.1021/jm980330i | ||
| 10603982 | 86860 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 625 | 12 | 2 | 8 | 4.0 | CCOC(=O)Cc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3C)cccc2n1C | 10.1021/jm980300f | ||
| CHEMBL21311 | 86860 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 625 | 12 | 2 | 8 | 4.0 | CCOC(=O)Cc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3C)cccc2n1C | 10.1021/jm980300f | ||
| 10603982 | 86860 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 625 | 12 | 2 | 8 | 4.0 | CCOC(=O)Cc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3C)cccc2n1C | 10.1021/jm030159x | ||
| CHEMBL21311 | 86860 | 0 | None | - | 0 | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 625 | 12 | 2 | 8 | 4.0 | CCOC(=O)Cc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3C)cccc2n1C | 10.1021/jm030159x | ||
| 10579143 | 175243 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 580 | 9 | 2 | 6 | 5.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4oc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL43510 | 175243 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 580 | 9 | 2 | 6 | 5.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4oc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 10579143 | 175243 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 580 | 9 | 2 | 6 | 5.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4oc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL43510 | 175243 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 580 | 9 | 2 | 6 | 5.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4oc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 18941161 | 16501 | 0 | None | - | 1 | Guinea pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 615 | 9 | 1 | 5 | 8.0 | Cc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4sc(-c5ccccc5)nc34)c2Cl)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113320 | 16501 | 0 | None | - | 1 | Guinea pig | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 615 | 9 | 1 | 5 | 8.0 | Cc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4sc(-c5ccccc5)nc34)c2Cl)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| 10675163 | 20014 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 603 | 7 | 2 | 5 | 6.4 | Cc1ccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL1191383 | 20014 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 603 | 7 | 2 | 5 | 6.4 | Cc1ccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL542472 | 20014 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 603 | 7 | 2 | 5 | 6.4 | Cc1ccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| 44190854 | 202224 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 435 | 6 | 1 | 6 | 4.2 | CC(=O)NCc1cncc(Cl)c1COc1cccc2c(-c3ccnn3C)cc(C)nc12 | 10.1021/jm9002445 | ||
| CHEMBL552384 | 202224 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 435 | 6 | 1 | 6 | 4.2 | CC(=O)NCc1cncc(Cl)c1COc1cccc2c(-c3ccnn3C)cc(C)nc12 | 10.1021/jm9002445 | ||
| 19603349 | 19980 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 685 | 10 | 3 | 7 | 6.9 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C(=O)Nc5ccncc5)c4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1191125 | 19980 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 685 | 10 | 3 | 7 | 6.9 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C(=O)Nc5ccncc5)c4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL542177 | 19980 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 685 | 10 | 3 | 7 | 6.9 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C(=O)Nc5ccncc5)c4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 11296863 | 20182 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 675 | 10 | 2 | 7 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCOCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL1192787 | 20182 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 675 | 10 | 2 | 7 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCOCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL3216859 | 20182 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 675 | 10 | 2 | 7 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCOCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 44353012 | 20161 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 600 | 8 | 1 | 5 | 6.1 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C\c4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1192626 | 20161 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 600 | 8 | 1 | 5 | 6.1 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C\c4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL543898 | 20161 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 600 | 8 | 1 | 5 | 6.1 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C\c4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10854681 | 126799 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 339 | 3 | 1 | 3 | 5.2 | Cc1nc2c(NCc3c(Cl)cccc3Cl)cccn2c1Cl | 10.1021/jm970591c | ||
| CHEMBL350232 | 126799 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 339 | 3 | 1 | 3 | 5.2 | Cc1nc2c(NCc3c(Cl)cccc3Cl)cccn2c1Cl | 10.1021/jm970591c | ||
| 176 | 7186 | 66 | None | -5 | 31 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
| 2157 | 7186 | 66 | None | -5 | 31 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
| 2566 | 7186 | 66 | None | -5 | 31 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
| CHEMBL633 | 7186 | 66 | None | -5 | 31 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
| DB01118 | 7186 | 66 | None | -5 | 31 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
| 11169915 | 20311 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 648 | 11 | 2 | 6 | 6.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OC(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL1193789 | 20311 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 648 | 11 | 2 | 6 | 6.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OC(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL545255 | 20311 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 648 | 11 | 2 | 6 | 6.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OC(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| 11445445 | 20490 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 701 | 10 | 1 | 7 | 6.2 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1195018 | 20490 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 701 | 10 | 1 | 7 | 6.2 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL3215999 | 20490 | 0 | None | - | 0 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 701 | 10 | 1 | 7 | 6.2 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 11801083 | 122026 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 565 | 9 | 1 | 6 | 4.6 | Cc1cnc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3C)c2n1 | 10.1021/jm980300f | ||
| CHEMBL334753 | 122026 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 565 | 9 | 1 | 6 | 4.6 | Cc1cnc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3C)c2n1 | 10.1021/jm980300f | ||
| 10530740 | 172371 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 552 | 9 | 2 | 7 | 4.3 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ncc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| CHEMBL424268 | 172371 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 552 | 9 | 2 | 7 | 4.3 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ncc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| 44189792 | 201914 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 401 | 4 | 0 | 5 | 5.9 | Cc1cc(-c2cncs2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL550142 | 201914 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 401 | 4 | 0 | 5 | 5.9 | Cc1cc(-c2cncs2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44340818 | 117386 | 0 | None | - | 1 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 539 | 8 | 1 | 5 | 6.3 | Cc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4scnc34)c2Cl)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL325624 | 117386 | 0 | None | - | 1 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 539 | 8 | 1 | 5 | 6.3 | Cc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4scnc34)c2Cl)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| 11801800 | 27932 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 604 | 9 | 1 | 5 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4cccc(C(=O)N(C)C)c4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL131263 | 27932 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 604 | 9 | 1 | 5 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4cccc(C(=O)N(C)C)c4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 119343 | 9649 | 22 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.03.006 | ||||
| 676 | 9649 | 22 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.03.006 | ||||
| CHEMBL446325 | 9649 | 22 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.03.006 | ||||
| 44190941 | 202210 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 471 | 7 | 1 | 7 | 3.6 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CNS(C)(=O)=O)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL552296 | 202210 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 471 | 7 | 1 | 7 | 3.6 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CNS(C)(=O)=O)c2n1 | 10.1021/jm9002445 | ||
| 119343 | 9649 | 22 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| 676 | 9649 | 22 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| CHEMBL446325 | 9649 | 22 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| 11800992 | 125560 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 559 | 9 | 2 | 4 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NC/C=C\c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| CHEMBL342016 | 125560 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 559 | 9 | 2 | 4 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NC/C=C\c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| 10627732 | 29239 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 623 | 10 | 1 | 7 | 5.0 | COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)cccc2n1C | 10.1021/jm980300f | ||
| CHEMBL132510 | 29239 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 623 | 10 | 1 | 7 | 5.0 | COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)cccc2n1C | 10.1021/jm980300f | ||
| 18941160 | 16687 | 0 | None | - | 1 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 553 | 8 | 1 | 5 | 6.6 | Cc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4sc(C)nc34)c2Cl)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL114401 | 16687 | 0 | None | - | 1 | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 553 | 8 | 1 | 5 | 6.6 | Cc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4sc(C)nc34)c2Cl)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| 10651302 | 20089 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 603 | 7 | 2 | 5 | 6.4 | Cc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL1192012 | 20089 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 603 | 7 | 2 | 5 | 6.4 | Cc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL543188 | 20089 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 603 | 7 | 2 | 5 | 6.4 | Cc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| 44190943 | 202732 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 471 | 7 | 0 | 7 | 5.5 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3COc3ccccn3)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL559564 | 202732 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 471 | 7 | 0 | 7 | 5.5 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3COc3ccccn3)c2n1 | 10.1021/jm9002445 | ||
| 10743094 | 52078 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 471 | 4 | 0 | 5 | 5.5 | COC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL152650 | 52078 | 0 | None | - | 0 | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 471 | 4 | 0 | 5 | 5.5 | COC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL2392354 | 217194 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1016/j.ejmech.2013.01.044 | ||||
| 10818067 | 20134 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 654 | 10 | 2 | 7 | 6.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1192427 | 20134 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 654 | 10 | 2 | 7 | 6.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL543659 | 20134 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 654 | 10 | 2 | 7 | 6.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 10722378 | 28112 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 604 | 7 | 3 | 6 | 5.7 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(N)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL131404 | 28112 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 604 | 7 | 3 | 6 | 5.7 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(N)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10698666 | 20779 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 589 | 7 | 2 | 5 | 6.1 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1197062 | 20779 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 589 | 7 | 2 | 5 | 6.1 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL559195 | 20779 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 589 | 7 | 2 | 5 | 6.1 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10651301 | 123306 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 603 | 7 | 2 | 5 | 6.4 | Cc1ccccc1NC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| CHEMBL336209 | 123306 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 603 | 7 | 2 | 5 | 6.4 | Cc1ccccc1NC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| 10604425 | 171926 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 661 | 9 | 2 | 7 | 6.3 | CCOC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL422794 | 171926 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 661 | 9 | 2 | 7 | 6.3 | CCOC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| 10552342 | 54342 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 469 | 5 | 0 | 4 | 5.7 | CCN(C(C)=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL154625 | 54342 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 469 | 5 | 0 | 4 | 5.7 | CCN(C(C)=O)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 10744917 | 125614 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 536 | 9 | 2 | 5 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2cccc(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980330i | ||
| CHEMBL342195 | 125614 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 536 | 9 | 2 | 5 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2cccc(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980330i | ||
| 10503130 | 19776 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 399 | 3 | 1 | 4 | 4.9 | Cc1nc2c(OCc3c(Cl)ccc(N)c3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| CHEMBL1189725 | 19776 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 399 | 3 | 1 | 4 | 4.9 | Cc1nc2c(OCc3c(Cl)ccc(N)c3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| CHEMBL539324 | 19776 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 399 | 3 | 1 | 4 | 4.9 | Cc1nc2c(OCc3c(Cl)ccc(N)c3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| 10737855 | 52773 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 368 | 3 | 0 | 3 | 4.8 | Cc1nc2c(OCc3c(F)cccc3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| CHEMBL153271 | 52773 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 368 | 3 | 0 | 3 | 4.8 | Cc1nc2c(OCc3c(F)cccc3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| 11239381 | 19916 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 688 | 10 | 2 | 7 | 5.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCN(C)CC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL1190638 | 19916 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 688 | 10 | 2 | 7 | 5.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCN(C)CC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL3215541 | 19916 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 688 | 10 | 2 | 7 | 5.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCN(C)CC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 10601892 | 53805 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 512 | 6 | 1 | 5 | 4.4 | CC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| CHEMBL154188 | 53805 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 512 | 6 | 1 | 5 | 4.4 | CC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| CHEMBL558018 | 53805 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 512 | 6 | 1 | 5 | 4.4 | CC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| 10699672 | 19729 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 6.1 | CC(=O)N(C)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL1189342 | 19729 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 6.1 | CC(=O)N(C)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL538531 | 19729 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 6.1 | CC(=O)N(C)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| 10601892 | 53805 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 512 | 6 | 1 | 5 | 4.4 | CC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL154188 | 53805 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 512 | 6 | 1 | 5 | 4.4 | CC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL558018 | 53805 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 512 | 6 | 1 | 5 | 4.4 | CC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 10531338 | 98482 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 582 | 10 | 2 | 7 | 4.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(N(C)C)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL240875 | 98482 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 582 | 10 | 2 | 7 | 4.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(N(C)C)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| 10531338 | 98482 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 582 | 10 | 2 | 7 | 4.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(N(C)C)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| CHEMBL240875 | 98482 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 582 | 10 | 2 | 7 | 4.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(N(C)C)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| 10506334 | 126417 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 526 | 6 | 0 | 5 | 4.7 | CC(=O)N(C)CC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL346718 | 126417 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 526 | 6 | 0 | 5 | 4.7 | CC(=O)N(C)CC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 11491041 | 20228 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 719 | 11 | 2 | 8 | 7.1 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL1193122 | 20228 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 719 | 11 | 2 | 8 | 7.1 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL544480 | 20228 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 719 | 11 | 2 | 8 | 7.1 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| 11800992 | 125560 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 559 | 9 | 2 | 4 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NC/C=C\c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| CHEMBL342016 | 125560 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 559 | 9 | 2 | 4 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NC/C=C\c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| 10744917 | 125614 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 536 | 9 | 2 | 5 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2cccc(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980330i | ||
| CHEMBL342195 | 125614 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 536 | 9 | 2 | 5 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2cccc(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980330i | ||
| 10579159 | 126085 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 582 | 11 | 2 | 7 | 4.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(OC)c(COc3cccc4ccc(C)nc34)c2OC)cc1 | 10.1021/jm980330i | ||
| CHEMBL344021 | 126085 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 582 | 11 | 2 | 7 | 4.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(OC)c(COc3cccc4ccc(C)nc34)c2OC)cc1 | 10.1021/jm980330i | ||
| 10674242 | 30929 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 551 | 9 | 2 | 6 | 4.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ncc(C)nc34)c2C)cc1 | 10.1021/jm980300f | ||
| CHEMBL133913 | 30929 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 551 | 9 | 2 | 6 | 4.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ncc(C)nc34)c2C)cc1 | 10.1021/jm980300f | ||
| 11801594 | 107208 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4nc(C)cnc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL290431 | 107208 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4nc(C)cnc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 11801594 | 107208 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4nc(C)cnc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL290431 | 107208 | 0 | None | - | 0 | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4nc(C)cnc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 10693943 | 126388 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 428 | 3 | 0 | 3 | 5.4 | Cc1nc2c(OCc3c(Br)cccc3Br)cccn2c1Cl | 10.1021/jm970591c | ||
| CHEMBL346458 | 126388 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 428 | 3 | 0 | 3 | 5.4 | Cc1nc2c(OCc3c(Br)cccc3Br)cccn2c1Cl | 10.1021/jm970591c | ||
| 10554743 | 121932 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 552 | 9 | 2 | 7 | 3.7 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ncc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| CHEMBL334421 | 121932 | 0 | None | - | 0 | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 552 | 9 | 2 | 7 | 3.7 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ncc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| 44190752 | 202125 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 476 | 6 | 0 | 8 | 5.5 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Sc3nccn3C)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL551759 | 202125 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 476 | 6 | 0 | 8 | 5.5 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Sc3nccn3C)c2n1 | 10.1021/jm9002445 | ||
| 10508305 | 20381 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 634 | 8 | 2 | 7 | 6.0 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc([N+](=O)[O-])c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1194233 | 20381 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 634 | 8 | 2 | 7 | 6.0 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc([N+](=O)[O-])c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL545765 | 20381 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 634 | 8 | 2 | 7 | 6.0 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc([N+](=O)[O-])c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10836951 | 54264 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 441 | 4 | 1 | 4 | 5.2 | CC(=O)Nc1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL154558 | 54264 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 441 | 4 | 1 | 4 | 5.2 | CC(=O)Nc1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 10518915 | 126342 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 308 | 3 | 0 | 3 | 4.2 | Cc1nc2c(OCc3c(F)cccc3F)cccn2c1Cl | 10.1021/jm970591c | ||
| CHEMBL346034 | 126342 | 0 | None | - | 0 | Guinea pig | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 308 | 3 | 0 | 3 | 4.2 | Cc1nc2c(OCc3c(F)cccc3F)cccn2c1Cl | 10.1021/jm970591c | ||
| 10649831 | 20141 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 526 | 7 | 1 | 5 | 4.8 | CCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL1192462 | 20141 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 526 | 7 | 1 | 5 | 4.8 | CCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL543700 | 20141 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 526 | 7 | 1 | 5 | 4.8 | CCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 11262636 | 20609 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 721 | 16 | 2 | 8 | 5.7 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(CCOC)CCOC)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL1195841 | 20609 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 721 | 16 | 2 | 8 | 5.7 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(CCOC)CCOC)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL3215972 | 20609 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 721 | 16 | 2 | 8 | 5.7 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(CCOC)CCOC)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 11801941 | 20619 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 614 | 7 | 2 | 6 | 5.9 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C#N)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1195904 | 20619 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 614 | 7 | 2 | 6 | 5.9 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C#N)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL555556 | 20619 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 614 | 7 | 2 | 6 | 5.9 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C#N)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10841637 | 20691 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 623 | 7 | 2 | 5 | 6.7 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(Cl)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1196403 | 20691 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 623 | 7 | 2 | 5 | 6.7 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(Cl)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL556816 | 20691 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 623 | 7 | 2 | 5 | 6.7 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(Cl)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 11181406 | 19710 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 663 | 11 | 2 | 7 | 5.7 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1OC | 10.1021/jm030326t | ||
| CHEMBL1189212 | 19710 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 663 | 11 | 2 | 7 | 5.7 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1OC | 10.1021/jm030326t | ||
| CHEMBL3217073 | 19710 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 663 | 11 | 2 | 7 | 5.7 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1OC | 10.1021/jm030326t | ||
| 11479285 | 19927 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 647 | 10 | 1 | 6 | 6.0 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL1190741 | 19927 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 647 | 10 | 1 | 6 | 6.0 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL3143958 | 19927 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 647 | 10 | 1 | 6 | 6.0 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| 11479285 | 19927 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 647 | 10 | 1 | 6 | 6.0 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1190741 | 19927 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 647 | 10 | 1 | 6 | 6.0 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL3143958 | 19927 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 647 | 10 | 1 | 6 | 6.0 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 10650330 | 19932 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 551 | 9 | 2 | 6 | 4.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| CHEMBL1190789 | 19932 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 551 | 9 | 2 | 6 | 4.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| CHEMBL541590 | 19932 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 551 | 9 | 2 | 6 | 4.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| 10604425 | 171926 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 661 | 9 | 2 | 7 | 6.3 | CCOC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL422794 | 171926 | 0 | None | - | 0 | Guinea pig | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 661 | 9 | 2 | 7 | 6.3 | CCOC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| 10722424 | 177738 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 609 | 10 | 2 | 7 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(OC)n4C)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL44557 | 177738 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 609 | 10 | 2 | 7 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(OC)n4C)c2Cl)cc1 | 10.1021/jm030159x | ||
| 19603349 | 19980 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 685 | 10 | 3 | 7 | 6.9 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C(=O)Nc5ccncc5)c4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1191125 | 19980 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 685 | 10 | 3 | 7 | 6.9 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C(=O)Nc5ccncc5)c4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL542177 | 19980 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 685 | 10 | 3 | 7 | 6.9 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C(=O)Nc5ccncc5)c4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 673 | 8466 | 15 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 5.8 | O=C(/C=C/c1ccc(cc1)C(=O)N(C)C)NCC(=O)N(c1ccc(c(c1Cl)COc1cccn2c1nc(c2Br)C)Cl)C | 10.1021/jm980300f | ||
| 9810391 | 8466 | 15 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 5.8 | O=C(/C=C/c1ccc(cc1)C(=O)N(C)C)NCC(=O)N(c1ccc(c(c1Cl)COc1cccn2c1nc(c2Br)C)Cl)C | 10.1021/jm980300f | ||
| CHEMBL1192627 | 8466 | 15 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 671 | 9 | 1 | 6 | 5.8 | O=C(/C=C/c1ccc(cc1)C(=O)N(C)C)NCC(=O)N(c1ccc(c(c1Cl)COc1cccn2c1nc(c2Br)C)Cl)C | 10.1021/jm980300f | ||
| 10722424 | 177738 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 609 | 10 | 2 | 7 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(OC)n4C)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL44557 | 177738 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 609 | 10 | 2 | 7 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(OC)n4C)c2Cl)cc1 | 10.1021/jm980300f | ||
| 5311114 | 8469 | 8 | None | - | 1 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 697 | 12 | 2 | 7 | 6.6 | CNC(=O)c1ccc(cc1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2OCc1ccccn1)Cl)C | 10.1021/jm030468n | ||
| 668 | 8469 | 8 | None | - | 1 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 697 | 12 | 2 | 7 | 6.6 | CNC(=O)c1ccc(cc1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2OCc1ccccn1)Cl)C | 10.1021/jm030468n | ||
| CHEMBL99869 | 8469 | 8 | None | - | 1 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 697 | 12 | 2 | 7 | 6.6 | CNC(=O)c1ccc(cc1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2OCc1ccccn1)Cl)C | 10.1021/jm030468n | ||
| 10841582 | 20015 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 619 | 8 | 2 | 6 | 6.1 | COc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL1191384 | 20015 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 619 | 8 | 2 | 6 | 6.1 | COc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL542473 | 20015 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 619 | 8 | 2 | 6 | 6.1 | COc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| 9894265 | 38312 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 569 | 9 | 2 | 4 | 7.1 | CNC(=O)c1ccc(/C=C/C(=O)NCc2ccccc2-c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980330i | ||
| CHEMBL140383 | 38312 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 569 | 9 | 2 | 4 | 7.1 | CNC(=O)c1ccc(/C=C/C(=O)NCc2ccccc2-c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980330i | ||
| 10793563 | 20612 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL1195858 | 20612 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL555465 | 20612 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 10769517 | 30228 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 577 | 9 | 1 | 6 | 5.1 | Cc1cnc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3C)c2n1 | 10.1021/jm980300f | ||
| CHEMBL133339 | 30228 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 577 | 9 | 1 | 6 | 5.1 | Cc1cnc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3C)c2n1 | 10.1021/jm980300f | ||
| 10840534 | 29345 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 555 | 8 | 1 | 6 | 3.9 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)CN(C)C)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL132620 | 29345 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 555 | 8 | 1 | 6 | 3.9 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)CN(C)C)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10349737 | 19888 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 658 | 9 | 2 | 7 | 5.4 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cn1 | 10.1021/jm980214f | ||
| CHEMBL1190430 | 19888 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 658 | 9 | 2 | 7 | 5.4 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cn1 | 10.1021/jm980214f | ||
| CHEMBL540840 | 19888 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 658 | 9 | 2 | 7 | 5.4 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cn1 | 10.1021/jm980214f | ||
| 10840534 | 29345 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 555 | 8 | 1 | 6 | 3.9 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)CN(C)C)c3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| CHEMBL132620 | 29345 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 555 | 8 | 1 | 6 | 3.9 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)CN(C)C)c3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| 11320262 | 214958 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 775 | 14 | 2 | 9 | 7.2 | Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)Cc5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm030468n | ||
| CHEMBL98349 | 214958 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 775 | 14 | 2 | 9 | 7.2 | Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)Cc5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm030468n | ||
| 11181524 | 214800 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 686 | 12 | 2 | 8 | 6.1 | COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc2n1Cc1ccccc1 | 10.1021/jm030468n | ||
| CHEMBL97393 | 214800 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 686 | 12 | 2 | 8 | 6.1 | COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc2n1Cc1ccccc1 | 10.1021/jm030468n | ||
| 11193509 | 20509 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 750 | 12 | 2 | 7 | 7.5 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1195125 | 20509 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 750 | 12 | 2 | 7 | 7.5 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL553897 | 20509 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 750 | 12 | 2 | 7 | 7.5 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 10818067 | 20134 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 654 | 10 | 2 | 7 | 6.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1192427 | 20134 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 654 | 10 | 2 | 7 | 6.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL543659 | 20134 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 654 | 10 | 2 | 7 | 6.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 10793563 | 20612 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL1195858 | 20612 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL555465 | 20612 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 10842202 | 20618 | 1 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 672 | 9 | 3 | 6 | 5.8 | CNC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL1195903 | 20618 | 1 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 672 | 9 | 3 | 6 | 5.8 | CNC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL555555 | 20618 | 1 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 672 | 9 | 3 | 6 | 5.8 | CNC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| 11343115 | 19846 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 692 | 13 | 2 | 8 | 5.5 | CCOC(=O)COc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/jm030468n | ||
| CHEMBL1190165 | 19846 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 692 | 13 | 2 | 8 | 5.5 | CCOC(=O)COc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/jm030468n | ||
| CHEMBL540300 | 19846 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 692 | 13 | 2 | 8 | 5.5 | CCOC(=O)COc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/jm030468n | ||
| 44360818 | 20250 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 783 | 14 | 1 | 8 | 10.3 | Cc1ccc2cccc(OCc3c(/C=C/c4ccncc4)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3/C=C/c3ccncc3)c2n1 | 10.1021/jm980330i | ||
| CHEMBL1193250 | 20250 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 783 | 14 | 1 | 8 | 10.3 | Cc1ccc2cccc(OCc3c(/C=C/c4ccncc4)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3/C=C/c3ccncc3)c2n1 | 10.1021/jm980330i | ||
| CHEMBL544623 | 20250 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 783 | 14 | 1 | 8 | 10.3 | Cc1ccc2cccc(OCc3c(/C=C/c4ccncc4)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(/C=C/c5ccncc5)nc4)c3/C=C/c3ccncc3)c2n1 | 10.1021/jm980330i | ||
| 9894265 | 38312 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 569 | 9 | 2 | 4 | 7.1 | CNC(=O)c1ccc(/C=C/C(=O)NCc2ccccc2-c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980330i | ||
| CHEMBL140383 | 38312 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 569 | 9 | 2 | 4 | 7.1 | CNC(=O)c1ccc(/C=C/C(=O)NCc2ccccc2-c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980330i | ||
| 10651302 | 20089 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 603 | 7 | 2 | 5 | 6.4 | Cc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL1192012 | 20089 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 603 | 7 | 2 | 5 | 6.4 | Cc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL543188 | 20089 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 603 | 7 | 2 | 5 | 6.4 | Cc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| 10604560 | 27177 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 676 | 10 | 3 | 7 | 5.7 | COCC(=O)Nc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL130660 | 27177 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 676 | 10 | 3 | 7 | 5.7 | COCC(=O)Nc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| 11250851 | 20389 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 5.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(-n5cccn5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL1194270 | 20389 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 5.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(-n5cccn5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL3216880 | 20389 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 5.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(-n5cccn5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 11296863 | 20182 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 675 | 10 | 2 | 7 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCOCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL1192787 | 20182 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 675 | 10 | 2 | 7 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCOCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL3216859 | 20182 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 675 | 10 | 2 | 7 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCOCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 10769485 | 27322 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 575 | 9 | 2 | 5 | 7.2 | CNC(=O)c1ccc(/C=C/C(=O)NCc2sccc2-c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980330i | ||
| CHEMBL130775 | 27322 | 0 | None | - | 0 | Guinea pig | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 575 | 9 | 2 | 5 | 7.2 | CNC(=O)c1ccc(/C=C/C(=O)NCc2sccc2-c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980330i | ||
| 10746877 | 20590 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 654 | 10 | 2 | 7 | 6.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1195721 | 20590 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 654 | 10 | 2 | 7 | 6.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL555202 | 20590 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 654 | 10 | 2 | 7 | 6.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 11479285 | 19927 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 647 | 10 | 1 | 6 | 6.0 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL1190741 | 19927 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 647 | 10 | 1 | 6 | 6.0 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL3143958 | 19927 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 647 | 10 | 1 | 6 | 6.0 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| 11479285 | 19927 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 647 | 10 | 1 | 6 | 6.0 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1190741 | 19927 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 647 | 10 | 1 | 6 | 6.0 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL3143958 | 19927 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 647 | 10 | 1 | 6 | 6.0 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 11343115 | 19846 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 692 | 13 | 2 | 8 | 5.5 | CCOC(=O)COc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/jm030468n | ||
| CHEMBL1190165 | 19846 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 692 | 13 | 2 | 8 | 5.5 | CCOC(=O)COc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/jm030468n | ||
| CHEMBL540300 | 19846 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 692 | 13 | 2 | 8 | 5.5 | CCOC(=O)COc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/jm030468n | ||
| 10818426 | 20133 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 690 | 11 | 3 | 7 | 5.5 | COCCNC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL1192425 | 20133 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 690 | 11 | 3 | 7 | 5.5 | COCCNC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL543657 | 20133 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 690 | 11 | 3 | 7 | 5.5 | COCCNC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| 10651980 | 20190 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 660 | 8 | 2 | 6 | 5.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C(=O)N(C)C)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1192832 | 20190 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 660 | 8 | 2 | 6 | 5.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C(=O)N(C)C)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL544135 | 20190 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 660 | 8 | 2 | 6 | 5.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C(=O)N(C)C)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 44190269 | 202975 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 415 | 4 | 0 | 5 | 6.3 | Cc1cc(-c2nscc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL561415 | 202975 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 415 | 4 | 0 | 5 | 6.3 | Cc1cc(-c2nscc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 10555263 | 107873 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 581 | 10 | 2 | 7 | 4.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(C(C)=O)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| CHEMBL295005 | 107873 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 581 | 10 | 2 | 7 | 4.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(C(C)=O)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| 10841582 | 20015 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 619 | 8 | 2 | 6 | 6.1 | COc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL1191384 | 20015 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 619 | 8 | 2 | 6 | 6.1 | COc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL542473 | 20015 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 619 | 8 | 2 | 6 | 6.1 | COc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| 44191220 | 201809 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 398 | 4 | 0 | 5 | 5.3 | Cc1cc(-n2ccnc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL549337 | 201809 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 398 | 4 | 0 | 5 | 5.3 | Cc1cc(-n2ccnc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44190168 | 201897 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 415 | 4 | 0 | 5 | 6.3 | Cc1cc(-c2csnc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL550016 | 201897 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 415 | 4 | 0 | 5 | 6.3 | Cc1cc(-c2csnc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44191224 | 203040 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 412 | 4 | 0 | 5 | 5.5 | Cc1cc(-c2ncc(C)n2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL561839 | 203040 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 412 | 4 | 0 | 5 | 5.5 | Cc1cc(-c2ncc(C)n2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 10569271 | 56760 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 340 | 3 | 0 | 3 | 5.2 | Cc1nc2c(OCc3c(Cl)cccc3Cl)cccn2c1Cl | 10.1021/jm970591c | ||
| CHEMBL156902 | 56760 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 340 | 3 | 0 | 3 | 5.2 | Cc1nc2c(OCc3c(Cl)cccc3Cl)cccn2c1Cl | 10.1021/jm970591c | ||
| 10555263 | 107873 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 581 | 10 | 2 | 7 | 4.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(C(C)=O)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL295005 | 107873 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 581 | 10 | 2 | 7 | 4.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(C(C)=O)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| 10699094 | 30033 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 619 | 10 | 2 | 6 | 5.5 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccnc3-n3c(C)ccc3C)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL133186 | 30033 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 619 | 10 | 2 | 6 | 5.5 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccnc3-n3c(C)ccc3C)c2Cl)cc1 | 10.1021/jm980300f | ||
| 127034153 | 145342 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 365 | 5 | 2 | 3 | 4.5 | CC(C)CN1[C@H](C)Cc2cc(O)ccc2[C@H]1c1ccc(/C=C/C(=O)O)cc1 | 10.1021/acsmedchemlett.5b00413 | ||
| CHEMBL3775378 | 145342 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 365 | 5 | 2 | 3 | 4.5 | CC(C)CN1[C@H](C)Cc2cc(O)ccc2[C@H]1c1ccc(/C=C/C(=O)O)cc1 | 10.1021/acsmedchemlett.5b00413 | ||
| 1016 | 10519 | 78 | None | -46 | 35 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
| 2561 | 10519 | 78 | None | -46 | 35 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
| 2733526 | 10519 | 78 | None | -46 | 35 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
| 5384 | 10519 | 78 | None | -46 | 35 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
| CHEMBL83 | 10519 | 78 | None | -46 | 35 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
| DB00675 | 10519 | 78 | None | -46 | 35 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
| 72548703 | 168346 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | ||
| CHEMBL4128926 | 168346 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | ||
| 11296704 | 20597 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 647 | 10 | 2 | 6 | 6.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1C | 10.1021/jm030326t | ||
| CHEMBL1195759 | 20597 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 647 | 10 | 2 | 6 | 6.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1C | 10.1021/jm030326t | ||
| CHEMBL3216408 | 20597 | 0 | None | - | 0 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 647 | 10 | 2 | 6 | 6.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1C | 10.1021/jm030326t | ||
| 22008929 | 16522 | 0 | None | - | 1 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 597 | 9 | 1 | 5 | 6.6 | COc1c(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)ccc(Cl)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113465 | 16522 | 0 | None | - | 1 | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 597 | 9 | 1 | 5 | 6.6 | COc1c(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)ccc(Cl)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| 44190268 | 203290 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 435 | 4 | 0 | 5 | 6.6 | Cc1cc(-c2ncsc2Cl)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL563516 | 203290 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 435 | 4 | 0 | 5 | 6.6 | Cc1cc(-c2ncsc2Cl)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 10579159 | 126085 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 582 | 11 | 2 | 7 | 4.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(OC)c(COc3cccc4ccc(C)nc34)c2OC)cc1 | 10.1021/jm980330i | ||
| CHEMBL344021 | 126085 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 582 | 11 | 2 | 7 | 4.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(OC)c(COc3cccc4ccc(C)nc34)c2OC)cc1 | 10.1021/jm980330i | ||
| 10791325 | 51536 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 491 | 5 | 0 | 5 | 4.7 | Cc1nc2c(OCc3c(Cl)ccc(N(C)S(C)(=O)=O)c3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| CHEMBL152158 | 51536 | 0 | None | - | 0 | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 491 | 5 | 0 | 5 | 4.7 | Cc1nc2c(OCc3c(Cl)ccc(N(C)S(C)(=O)=O)c3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| 10841393 | 20055 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.2 | CCc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc2n1C | 10.1021/jm030159x | ||
| CHEMBL1191700 | 20055 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.2 | CCc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc2n1C | 10.1021/jm030159x | ||
| CHEMBL542836 | 20055 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.2 | CCc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc2n1C | 10.1021/jm030159x | ||
| 10841393 | 20055 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.2 | CCc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc2n1C | 10.1021/jm980300f | ||
| CHEMBL1191700 | 20055 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.2 | CCc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc2n1C | 10.1021/jm980300f | ||
| CHEMBL542836 | 20055 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.2 | CCc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc2n1C | 10.1021/jm980300f | ||
| 10792967 | 85302 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 559 | 9 | 2 | 4 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NC/C=C/c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| CHEMBL2111974 | 85302 | 0 | None | - | 0 | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 559 | 9 | 2 | 4 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NC/C=C/c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| 10507708 | 168602 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 593 | 9 | 2 | 5 | 6.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(C)c(C)oc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL41446 | 168602 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 593 | 9 | 2 | 5 | 6.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(C)c(C)oc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 10507708 | 168602 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 593 | 9 | 2 | 5 | 6.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(C)c(C)oc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL41446 | 168602 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 593 | 9 | 2 | 5 | 6.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(C)c(C)oc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 9851817 | 16453 | 0 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 607 | 8 | 1 | 5 | 7.3 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(F)(F)F)cc4)c3Cl)cccc2s1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL112991 | 16453 | 0 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 607 | 8 | 1 | 5 | 7.3 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(F)(F)F)cc4)c3Cl)cccc2s1 | 10.1016/s0960-894x(98)00736-7 | ||
| 10762703 | 54029 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 384 | 3 | 0 | 3 | 5.3 | Cc1nc2c(OCc3c(Cl)cccc3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| CHEMBL154386 | 54029 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 384 | 3 | 0 | 3 | 5.3 | Cc1nc2c(OCc3c(Cl)cccc3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| 44323787 | 19788 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 659 | 10 | 2 | 6 | 6.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL1189812 | 19788 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 659 | 10 | 2 | 6 | 6.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL3215529 | 19788 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 659 | 10 | 2 | 6 | 6.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 11468071 | 19809 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 676 | 13 | 3 | 7 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(NCCN(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL1189943 | 19809 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 676 | 13 | 3 | 7 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(NCCN(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL539800 | 19809 | 0 | None | - | 0 | Guinea pig | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 676 | 13 | 3 | 7 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(NCCN(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 10555061 | 123744 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 568 | 10 | 1 | 5 | 6.0 | CCCCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| CHEMBL338682 | 123744 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 568 | 10 | 1 | 5 | 6.0 | CCCCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| 11411594 | 19680 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 736 | 11 | 2 | 7 | 7.9 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1189023 | 19680 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 736 | 11 | 2 | 7 | 7.9 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL537927 | 19680 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 736 | 11 | 2 | 7 | 7.9 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 11239502 | 20475 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 674 | 11 | 2 | 6 | 6.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OC5CCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL1194911 | 20475 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 674 | 11 | 2 | 6 | 6.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OC5CCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL553530 | 20475 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 674 | 11 | 2 | 6 | 6.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OC5CCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| 44340760 | 117285 | 0 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 523 | 10 | 3 | 6 | 3.8 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCCCC(=O)O)c3C#N)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL324950 | 117285 | 0 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 523 | 10 | 3 | 6 | 3.8 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCCCC(=O)O)c3C#N)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| 11468071 | 19809 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 676 | 13 | 3 | 7 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(NCCN(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL1189943 | 19809 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 676 | 13 | 3 | 7 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(NCCN(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL539800 | 19809 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 676 | 13 | 3 | 7 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(NCCN(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 11181524 | 214800 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 686 | 12 | 2 | 8 | 6.1 | COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc2n1Cc1ccccc1 | 10.1021/jm030468n | ||
| CHEMBL97393 | 214800 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 686 | 12 | 2 | 8 | 6.1 | COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc2n1Cc1ccccc1 | 10.1021/jm030468n | ||
| 10816636 | 20539 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 555 | 8 | 2 | 5 | 5.0 | CCCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL1195365 | 20539 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 555 | 8 | 2 | 5 | 5.0 | CCCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL554412 | 20539 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 555 | 8 | 2 | 5 | 5.0 | CCCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 10841531 | 27330 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 617 | 9 | 1 | 6 | 5.7 | Cc1cnc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL130782 | 27330 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 617 | 9 | 1 | 6 | 5.7 | Cc1cnc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 44214279 | 16488 | 0 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 489 | 8 | 1 | 5 | 5.3 | C=C/C=C/C(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccc3sc(C)nc23)c1Cl | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113222 | 16488 | 0 | None | - | 1 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 489 | 8 | 1 | 5 | 5.3 | C=C/C=C/C(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccc3sc(C)nc23)c1Cl | 10.1016/s0960-894x(98)00736-7 | ||
| 10675163 | 20014 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 603 | 7 | 2 | 5 | 6.4 | Cc1ccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL1191383 | 20014 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 603 | 7 | 2 | 5 | 6.4 | Cc1ccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| CHEMBL542472 | 20014 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 603 | 7 | 2 | 5 | 6.4 | Cc1ccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980214f | ||
| 10507708 | 168602 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 593 | 9 | 2 | 5 | 6.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(C)c(C)oc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL41446 | 168602 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 593 | 9 | 2 | 5 | 6.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(C)c(C)oc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 10507708 | 168602 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 593 | 9 | 2 | 5 | 6.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(C)c(C)oc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL41446 | 168602 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 593 | 9 | 2 | 5 | 6.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(C)c(C)oc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 11422667 | 19757 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 710 | 12 | 2 | 7 | 6.6 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1189575 | 19757 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 710 | 12 | 2 | 7 | 6.6 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL539023 | 19757 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 710 | 12 | 2 | 7 | 6.6 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 11456756 | 20581 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 699 | 10 | 1 | 6 | 7.3 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1195624 | 20581 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 699 | 10 | 1 | 6 | 7.3 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL3216405 | 20581 | 0 | None | - | 0 | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 699 | 10 | 1 | 6 | 7.3 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 10555202 | 123530 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 577 | 9 | 3 | 6 | 5.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)Nc2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1 | 10.1021/jm980330i | ||
| CHEMBL337555 | 123530 | 0 | None | - | 0 | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 577 | 9 | 3 | 6 | 5.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)Nc2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1 | 10.1021/jm980330i | ||
| 11468276 | 20285 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 738 | 11 | 2 | 8 | 6.7 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1193590 | 20285 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 738 | 11 | 2 | 8 | 6.7 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL545021 | 20285 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 738 | 11 | 2 | 8 | 6.7 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 15388873 | 121509 | 0 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 529 | 8 | 1 | 6 | 5.9 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccco4)c3Cl)cccc2s1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL333832 | 121509 | 0 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 529 | 8 | 1 | 6 | 5.9 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccco4)c3Cl)cccc2s1 | 10.1016/s0960-894x(98)00736-7 | ||
| 11801594 | 107208 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4nc(C)cnc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL290431 | 107208 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4nc(C)cnc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 11801594 | 107208 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4nc(C)cnc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL290431 | 107208 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4nc(C)cnc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 10009762 | 19701 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 678 | 10 | 1 | 7 | 7.4 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL1189175 | 19701 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 678 | 10 | 1 | 7 | 7.4 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL3217072 | 19701 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 678 | 10 | 1 | 7 | 7.4 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| 10579332 | 20526 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL1195281 | 20526 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL554206 | 20526 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 11239019 | 20259 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 626 | 10 | 2 | 5 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c(-c5ccccc5)cc(C)nc34)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL1193332 | 20259 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 626 | 10 | 2 | 5 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c(-c5ccccc5)cc(C)nc34)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL544720 | 20259 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 626 | 10 | 2 | 5 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c(-c5ccccc5)cc(C)nc34)c2C)cc1 | 10.1021/jm030159x | ||
| 11399463 | 20229 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 633 | 10 | 2 | 6 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL1193123 | 20229 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 633 | 10 | 2 | 6 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL3143949 | 20229 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 633 | 10 | 2 | 6 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 11399463 | 20229 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 633 | 10 | 2 | 6 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL1193123 | 20229 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 633 | 10 | 2 | 6 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL3143949 | 20229 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 633 | 10 | 2 | 6 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 44361029 | 20138 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 714 | 11 | 1 | 7 | 5.3 | Cc1ccc2cccc(OCc3c(N4CCCC4=O)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3N3CCCC3=O)c2n1 | 10.1021/jm980330i | ||
| CHEMBL1192448 | 20138 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 714 | 11 | 1 | 7 | 5.3 | Cc1ccc2cccc(OCc3c(N4CCCC4=O)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3N3CCCC3=O)c2n1 | 10.1021/jm980330i | ||
| CHEMBL543685 | 20138 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 714 | 11 | 1 | 7 | 5.3 | Cc1ccc2cccc(OCc3c(N4CCCC4=O)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3N3CCCC3=O)c2n1 | 10.1021/jm980330i | ||
| 10555818 | 20457 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 616 | 9 | 1 | 5 | 6.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1194778 | 20457 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 616 | 9 | 1 | 5 | 6.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL553293 | 20457 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 616 | 9 | 1 | 5 | 6.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 10746877 | 20590 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 654 | 10 | 2 | 7 | 6.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1195721 | 20590 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 654 | 10 | 2 | 7 | 6.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL555202 | 20590 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 654 | 10 | 2 | 7 | 6.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 667 | 8754 | 37 | None | -1 | 6 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980300f | ||||
| 6918173 | 8754 | 37 | None | -1 | 6 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980300f | ||||
| 71364 | 8754 | 37 | None | -1 | 6 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980300f | ||||
| CHEMBL2028850 | 8754 | 37 | None | -1 | 6 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980300f | ||||
| DB06196 | 8754 | 37 | None | -1 | 6 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980300f | ||||
| 667 | 8754 | 37 | None | -1 | 6 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980214f | ||||
| 6918173 | 8754 | 37 | None | -1 | 6 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980214f | ||||
| 71364 | 8754 | 37 | None | -1 | 6 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980214f | ||||
| CHEMBL2028850 | 8754 | 37 | None | -1 | 6 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980214f | ||||
| DB06196 | 8754 | 37 | None | -1 | 6 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm980214f | ||||
| 9874617 | 20078 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 670 | 10 | 1 | 7 | 6.1 | Cc1cc(-n2cccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL1191908 | 20078 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 670 | 10 | 1 | 7 | 6.1 | Cc1cc(-n2cccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL543070 | 20078 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 670 | 10 | 1 | 7 | 6.1 | Cc1cc(-n2cccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| 10674242 | 30929 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 551 | 9 | 2 | 6 | 4.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ncc(C)nc34)c2C)cc1 | 10.1021/jm980300f | ||
| CHEMBL133913 | 30929 | 0 | None | - | 0 | Guinea pig | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 551 | 9 | 2 | 6 | 4.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ncc(C)nc34)c2C)cc1 | 10.1021/jm980300f | ||
| 11169752 | 119186 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 654 | 13 | 2 | 9 | 4.7 | COCCn1c(OC)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc21 | 10.1021/jm030468n | ||
| CHEMBL329758 | 119186 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 654 | 13 | 2 | 9 | 4.7 | COCCn1c(OC)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc21 | 10.1021/jm030468n | ||
| 10652092 | 19789 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 672 | 9 | 1 | 7 | 5.2 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)nc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1189828 | 19789 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 672 | 9 | 1 | 7 | 5.2 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)nc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL539550 | 19789 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 672 | 9 | 1 | 7 | 5.2 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)nc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 11273808 | 20570 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 5.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(-n5ccnc5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL1195573 | 20570 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 5.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(-n5ccnc5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL3215979 | 20570 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 5.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(-n5ccnc5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 11491069 | 19688 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 691 | 12 | 2 | 7 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OCC(=O)N(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL1189082 | 19688 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 691 | 12 | 2 | 7 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OCC(=O)N(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL538020 | 19688 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 691 | 12 | 2 | 7 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OCC(=O)N(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| 10841637 | 20691 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 623 | 7 | 2 | 5 | 6.7 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(Cl)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1196403 | 20691 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 623 | 7 | 2 | 5 | 6.7 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(Cl)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL556816 | 20691 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 623 | 7 | 2 | 5 | 6.7 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(Cl)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10580536 | 19712 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 693 | 10 | 2 | 7 | 5.5 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NS(C)(=O)=O)cc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1189218 | 19712 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 693 | 10 | 2 | 7 | 5.5 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NS(C)(=O)=O)cc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL538281 | 19712 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 693 | 10 | 2 | 7 | 5.5 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NS(C)(=O)=O)cc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10603710 | 20433 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 604 | 9 | 1 | 5 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL1194615 | 20433 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 604 | 9 | 1 | 5 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL552986 | 20433 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 604 | 9 | 1 | 5 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| 44360617 | 20249 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 678 | 11 | 1 | 7 | 4.0 | Cc1ccc2cccc(OCc3c(C(=O)N(C)C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3C(=O)N(C)C)c2n1 | 10.1021/jm980330i | ||
| CHEMBL1193249 | 20249 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 678 | 11 | 1 | 7 | 4.0 | Cc1ccc2cccc(OCc3c(C(=O)N(C)C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3C(=O)N(C)C)c2n1 | 10.1021/jm980330i | ||
| CHEMBL544622 | 20249 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 678 | 11 | 1 | 7 | 4.0 | Cc1ccc2cccc(OCc3c(C(=O)N(C)C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3C(=O)N(C)C)c2n1 | 10.1021/jm980330i | ||
| 10603710 | 20433 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 604 | 9 | 1 | 5 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1194615 | 20433 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 604 | 9 | 1 | 5 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL552986 | 20433 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 604 | 9 | 1 | 5 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 11491069 | 19688 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 691 | 12 | 2 | 7 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OCC(=O)N(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL1189082 | 19688 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 691 | 12 | 2 | 7 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OCC(=O)N(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL538020 | 19688 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 691 | 12 | 2 | 7 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OCC(=O)N(C)C)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| 11365972 | 20415 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 687 | 10 | 1 | 6 | 6.9 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1194477 | 20415 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 687 | 10 | 1 | 6 | 6.9 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL3216391 | 20415 | 0 | None | - | 0 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 687 | 10 | 1 | 6 | 6.9 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 10818058 | 123362 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 653 | 10 | 2 | 6 | 6.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL336574 | 123362 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 653 | 10 | 2 | 6 | 6.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 10840241 | 123247 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 541 | 7 | 2 | 5 | 4.6 | CCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| CHEMBL336116 | 123247 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 541 | 7 | 2 | 5 | 4.6 | CCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| 44191226 | 202081 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 384 | 4 | 1 | 4 | 5.2 | Cc1cc(-c2ccn[nH]2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL551435 | 202081 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 384 | 4 | 1 | 4 | 5.2 | Cc1cc(-c2ccn[nH]2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 10756101 | 52855 | 4 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 292 | 3 | 0 | 3 | 4.2 | Clc1cccc(Cl)c1COc1cccn2ccnc12 | 10.1021/jm970591c | ||
| CHEMBL153344 | 52855 | 4 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 292 | 3 | 0 | 3 | 4.2 | Clc1cccc(Cl)c1COc1cccn2ccnc12 | 10.1021/jm970591c | ||
| 44369201 | 128235 | 0 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 381 | 5 | 0 | 4 | 5.8 | CCn1c(C)cc(C#N)c1-c1ccc(COc2cc(C)nc3ccccc23)cc1 | 10.1021/jm970591c | ||
| CHEMBL358232 | 128235 | 0 | None | - | 0 | Guinea pig | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 381 | 5 | 0 | 4 | 5.8 | CCn1c(C)cc(C#N)c1-c1ccc(COc2cc(C)nc3ccccc23)cc1 | 10.1021/jm970591c | ||
| 44191225 | 203175 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 384 | 4 | 0 | 5 | 5.0 | Cc1cc(-n2cccn2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL562747 | 203175 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 384 | 4 | 0 | 5 | 5.0 | Cc1cc(-n2cccn2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL2372276 | 216985 | 0 | None | 3 | 3 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)[C@@H]1CCCN1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CCCN=C(N)N)C(=O)O | 10.1021/jm8007618 | ||||
| 44341214 | 117207 | 0 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 621 | 12 | 1 | 6 | 6.7 | CCCOc1c(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)ccc(OC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL324575 | 117207 | 0 | None | - | 1 | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 621 | 12 | 1 | 6 | 6.7 | CCCOc1c(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)ccc(OC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| 44190853 | 203068 | 4 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 435 | 7 | 1 | 6 | 4.0 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CCC(N)=O)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL562097 | 203068 | 4 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 435 | 7 | 1 | 6 | 4.0 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CCC(N)=O)c2n1 | 10.1021/jm9002445 | ||
| 11250929 | 20607 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 634 | 11 | 2 | 6 | 6.0 | CCOc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/acs.jmedchem.5b00982 | ||
| CHEMBL1195824 | 20607 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 634 | 11 | 2 | 6 | 6.0 | CCOc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/acs.jmedchem.5b00982 | ||
| CHEMBL555403 | 20607 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 634 | 11 | 2 | 6 | 6.0 | CCOc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/acs.jmedchem.5b00982 | ||
| 11250929 | 20607 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 634 | 11 | 2 | 6 | 6.0 | CCOc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/jm030468n | ||
| CHEMBL1195824 | 20607 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 634 | 11 | 2 | 6 | 6.0 | CCOc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/jm030468n | ||
| CHEMBL555403 | 20607 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 634 | 11 | 2 | 6 | 6.0 | CCOc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/jm030468n | ||
| 10579723 | 28089 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 617 | 7 | 2 | 6 | 5.4 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NC(=O)c4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL131380 | 28089 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 617 | 7 | 2 | 6 | 5.4 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NC(=O)c4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 9958759 | 20243 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 533 | 8 | 1 | 4 | 6.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccccc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1193231 | 20243 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 533 | 8 | 1 | 4 | 6.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccccc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL544601 | 20243 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 533 | 8 | 1 | 4 | 6.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccccc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 10699094 | 30033 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 619 | 10 | 2 | 6 | 5.5 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccnc3-n3c(C)ccc3C)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL133186 | 30033 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 619 | 10 | 2 | 6 | 5.5 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccnc3-n3c(C)ccc3C)c2Cl)cc1 | 10.1021/jm980300f | ||
| 10627456 | 26922 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 602 | 9 | 1 | 5 | 6.0 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)CCc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL130452 | 26922 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 602 | 9 | 1 | 5 | 6.0 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)CCc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10504612 | 127908 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 470 | 4 | 1 | 4 | 5.1 | CNC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL357530 | 127908 | 0 | None | - | 0 | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 470 | 4 | 1 | 4 | 5.1 | CNC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 10699094 | 30033 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 619 | 10 | 2 | 6 | 5.5 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccnc3-n3c(C)ccc3C)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL133186 | 30033 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 619 | 10 | 2 | 6 | 5.5 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccnc3-n3c(C)ccc3C)c2Cl)cc1 | 10.1021/jm980300f | ||
| 44190756 | 202216 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 463 | 7 | 0 | 6 | 4.6 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CCC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL552359 | 202216 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 463 | 7 | 0 | 6 | 4.6 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CCC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| 44189790 | 203421 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 398 | 4 | 1 | 4 | 5.5 | Cc1cc(-c2cn[nH]c2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL564341 | 203421 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 398 | 4 | 1 | 4 | 5.5 | Cc1cc(-c2cn[nH]c2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44190754 | 203227 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 497 | 7 | 0 | 7 | 3.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3[S+]([O-])CC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL563068 | 203227 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 497 | 7 | 0 | 7 | 3.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3[S+]([O-])CC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| 11239595 | 20495 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 738 | 11 | 2 | 8 | 6.7 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1195041 | 20495 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 738 | 11 | 2 | 8 | 6.7 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL553762 | 20495 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 738 | 11 | 2 | 8 | 6.7 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 11433935 | 19978 | 1 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 687 | 10 | 2 | 6 | 7.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCCCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL1191123 | 19978 | 1 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 687 | 10 | 2 | 6 | 7.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCCCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL3215986 | 19978 | 1 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 687 | 10 | 2 | 6 | 7.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCCCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 10531338 | 98482 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 582 | 10 | 2 | 7 | 4.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(N(C)C)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| CHEMBL240875 | 98482 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 582 | 10 | 2 | 7 | 4.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(N(C)C)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| 10531338 | 98482 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 582 | 10 | 2 | 7 | 4.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(N(C)C)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL240875 | 98482 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 582 | 10 | 2 | 7 | 4.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(N(C)C)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| 10579143 | 175243 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 580 | 9 | 2 | 6 | 5.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4oc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL43510 | 175243 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 580 | 9 | 2 | 6 | 5.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4oc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 10790603 | 51938 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 470 | 5 | 1 | 5 | 4.2 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CN)c3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| CHEMBL152542 | 51938 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 470 | 5 | 1 | 5 | 4.2 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CN)c3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| 10579143 | 175243 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 580 | 9 | 2 | 6 | 5.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4oc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL43510 | 175243 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 580 | 9 | 2 | 6 | 5.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4oc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 10555195 | 20016 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 577 | 9 | 1 | 6 | 5.1 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)nc4)c3C)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1191388 | 20016 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 577 | 9 | 1 | 6 | 5.1 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)nc4)c3C)c2n1 | 10.1021/jm980300f | ||
| CHEMBL542479 | 20016 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 577 | 9 | 1 | 6 | 5.1 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)nc4)c3C)c2n1 | 10.1021/jm980300f | ||
| 44346506 | 18211 | 0 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 545 | 29 | 0 | 0 | 12.9 | CCCC[P+](CCCC)(CCCC)CCCCCCCCCC[P+](CCCC)(CCCC)CCCC | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1180320 | 18211 | 0 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 545 | 29 | 0 | 0 | 12.9 | CCCC[P+](CCCC)(CCCC)CCCCCCCCCC[P+](CCCC)(CCCC)CCCC | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL121851 | 18211 | 0 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 545 | 29 | 0 | 0 | 12.9 | CCCC[P+](CCCC)(CCCC)CCCCCCCCCC[P+](CCCC)(CCCC)CCCC | 10.1016/0960-894X(95)00035-R | ||
| 44340964 | 16479 | 0 | None | - | 1 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 609 | 10 | 1 | 6 | 6.7 | COc1c(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)ccc(SC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113176 | 16479 | 0 | None | - | 1 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 609 | 10 | 1 | 6 | 6.7 | COc1c(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)ccc(SC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| 44190944 | 202712 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 539 | 6 | 0 | 7 | 5.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL559436 | 202712 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 539 | 6 | 0 | 7 | 5.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | 10.1021/jm9002445 | ||
| 11479294 | 20596 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 648 | 10 | 1 | 7 | 5.4 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)nc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1195758 | 20596 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 648 | 10 | 1 | 7 | 5.4 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)nc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL3216404 | 20596 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 648 | 10 | 1 | 7 | 5.4 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)nc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 11801083 | 122026 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 565 | 9 | 1 | 6 | 4.6 | Cc1cnc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3C)c2n1 | 10.1021/jm980300f | ||
| CHEMBL334753 | 122026 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 565 | 9 | 1 | 6 | 4.6 | Cc1cnc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3C)c2n1 | 10.1021/jm980300f | ||
| 10604613 | 19885 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 683 | 9 | 1 | 6 | 6.2 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1190420 | 19885 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 683 | 9 | 1 | 6 | 6.2 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL540828 | 19885 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 683 | 9 | 1 | 6 | 6.2 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 11422541 | 214946 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 682 | 13 | 2 | 10 | 4.6 | CCOC(=O)Cn1c(OC)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc21 | 10.1021/jm030468n | ||
| CHEMBL98292 | 214946 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 682 | 13 | 2 | 10 | 4.6 | CCOC(=O)Cn1c(OC)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc21 | 10.1021/jm030468n | ||
| 10508305 | 20381 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 634 | 8 | 2 | 7 | 6.0 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc([N+](=O)[O-])c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1194233 | 20381 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 634 | 8 | 2 | 7 | 6.0 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc([N+](=O)[O-])c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL545765 | 20381 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 634 | 8 | 2 | 7 | 6.0 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc([N+](=O)[O-])c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 18923274 | 26597 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 604 | 9 | 1 | 6 | 5.4 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)COc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL130196 | 26597 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 604 | 9 | 1 | 6 | 5.4 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)COc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10675243 | 103555 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 610 | 10 | 2 | 8 | 4.6 | COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc2n1C | 10.1021/jm030468n | ||
| CHEMBL264751 | 103555 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 610 | 10 | 2 | 8 | 4.6 | COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc2n1C | 10.1021/jm030468n | ||
| 11490605 | 20523 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 634 | 10 | 2 | 7 | 5.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| CHEMBL1195242 | 20523 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 634 | 10 | 2 | 7 | 5.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| CHEMBL554127 | 20523 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 634 | 10 | 2 | 7 | 5.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| 10675243 | 103555 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 610 | 10 | 2 | 8 | 4.6 | COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc2n1C | 10.1021/jm980300f | ||
| CHEMBL264751 | 103555 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 610 | 10 | 2 | 8 | 4.6 | COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc2n1C | 10.1021/jm980300f | ||
| 11445288 | 20648 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 670 | 10 | 1 | 7 | 6.1 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL1196072 | 20648 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 670 | 10 | 1 | 7 | 6.1 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL3217085 | 20648 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 670 | 10 | 1 | 7 | 6.1 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| 18704946 | 19942 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 657 | 10 | 2 | 8 | 5.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(-n5cncn5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL1190879 | 19942 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 657 | 10 | 2 | 8 | 5.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(-n5cncn5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL3217081 | 19942 | 0 | None | - | 0 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 657 | 10 | 2 | 8 | 5.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(-n5cncn5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 11169752 | 119186 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 654 | 13 | 2 | 9 | 4.7 | COCCn1c(OC)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc21 | 10.1021/jm030468n | ||
| CHEMBL329758 | 119186 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 654 | 13 | 2 | 9 | 4.7 | COCCn1c(OC)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3Cl)cccc21 | 10.1021/jm030468n | ||
| 44360879 | 19743 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 637 | 11 | 4 | 8 | 2.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C(=O)NC)c(COc3cccc4ccc(C)nc34)c2C(=O)NC)cn1 | 10.1021/jm980330i | ||
| CHEMBL1189464 | 19743 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 637 | 11 | 4 | 8 | 2.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C(=O)NC)c(COc3cccc4ccc(C)nc34)c2C(=O)NC)cn1 | 10.1021/jm980330i | ||
| CHEMBL538784 | 19743 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 637 | 11 | 4 | 8 | 2.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C(=O)NC)c(COc3cccc4ccc(C)nc34)c2C(=O)NC)cn1 | 10.1021/jm980330i | ||
| 10531497 | 19985 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1 | 10.1021/jm980300f | ||
| CHEMBL1191172 | 19985 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1 | 10.1021/jm980300f | ||
| CHEMBL542232 | 19985 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1 | 10.1021/jm980300f | ||
| 10580536 | 19712 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 693 | 10 | 2 | 7 | 5.5 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NS(C)(=O)=O)cc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1189218 | 19712 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 693 | 10 | 2 | 7 | 5.5 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NS(C)(=O)=O)cc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL538281 | 19712 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 693 | 10 | 2 | 7 | 5.5 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NS(C)(=O)=O)cc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10745254 | 42101 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 550 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL143697 | 42101 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 550 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL543781 | 42101 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 550 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm030159x | ||
| 11296704 | 20597 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 647 | 10 | 2 | 6 | 6.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1C | 10.1021/jm030326t | ||
| CHEMBL1195759 | 20597 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 647 | 10 | 2 | 6 | 6.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1C | 10.1021/jm030326t | ||
| CHEMBL3216408 | 20597 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 647 | 10 | 2 | 6 | 6.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1C | 10.1021/jm030326t | ||
| 10745254 | 42101 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 550 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980330i | ||
| CHEMBL143697 | 42101 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 550 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980330i | ||
| CHEMBL543781 | 42101 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 550 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980330i | ||
| 10745254 | 42101 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 550 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980300f | ||
| CHEMBL143697 | 42101 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 550 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980300f | ||
| CHEMBL543781 | 42101 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 550 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980300f | ||
| 11193509 | 20509 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 750 | 12 | 2 | 7 | 7.5 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1195125 | 20509 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 750 | 12 | 2 | 7 | 7.5 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL553897 | 20509 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 750 | 12 | 2 | 7 | 7.5 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 11331301 | 20059 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 663 | 13 | 3 | 7 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(NCCOC)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL1191763 | 20059 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 663 | 13 | 3 | 7 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(NCCOC)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL3215537 | 20059 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 663 | 13 | 3 | 7 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(NCCOC)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 44375675 | 63280 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 605 | 12 | 4 | 7 | 4.9 | O=C(O)CN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1016/s0960-894x(01)00044-0 | ||
| CHEMBL163506 | 63280 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 605 | 12 | 4 | 7 | 4.9 | O=C(O)CN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1016/s0960-894x(01)00044-0 | ||
| 10789357 | 54347 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 441 | 5 | 0 | 4 | 5.7 | CCN(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL154633 | 54347 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 441 | 5 | 0 | 4 | 5.7 | CCN(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 10601892 | 53805 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 512 | 6 | 1 | 5 | 4.4 | CC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| CHEMBL154188 | 53805 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 512 | 6 | 1 | 5 | 4.4 | CC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| CHEMBL558018 | 53805 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 512 | 6 | 1 | 5 | 4.4 | CC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| 11796916 | 56754 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 429 | 4 | 0 | 5 | 5.2 | Cc1nc2c(OCc3c(Cl)ccc([N+](=O)[O-])c3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| CHEMBL156899 | 56754 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 429 | 4 | 0 | 5 | 5.2 | Cc1nc2c(OCc3c(Cl)ccc([N+](=O)[O-])c3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| 44190165 | 202742 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 401 | 4 | 0 | 5 | 5.9 | Cc1cc(-c2nccs2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL559645 | 202742 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 401 | 4 | 0 | 5 | 5.9 | Cc1cc(-c2nccs2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 11799290 | 56699 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 489 | 4 | 0 | 4 | 5.9 | CC(=O)N(C)c1c(Cl)cc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL156847 | 56699 | 0 | None | - | 0 | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 489 | 4 | 0 | 4 | 5.9 | CC(=O)N(C)c1c(Cl)cc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 10555202 | 123530 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 577 | 9 | 3 | 6 | 5.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)Nc2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1 | 10.1021/jm980330i | ||
| CHEMBL337555 | 123530 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 577 | 9 | 3 | 6 | 5.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)Nc2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1 | 10.1021/jm980330i | ||
| 9916589 | 107014 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 593 | 9 | 2 | 6 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(C)n4C)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL288603 | 107014 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 593 | 9 | 2 | 6 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(C)n4C)c2Cl)cc1 | 10.1021/jm980300f | ||
| 11377448 | 19827 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 689 | 10 | 1 | 7 | 5.8 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1190058 | 19827 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 689 | 10 | 1 | 7 | 5.8 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL3216622 | 19827 | 0 | None | - | 0 | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 689 | 10 | 1 | 7 | 5.8 | Cc1cc(N2CCOCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 44190361 | 201582 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 399 | 4 | 0 | 5 | 5.8 | Cc1cc(-c2conc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL538865 | 201582 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 399 | 4 | 0 | 5 | 5.8 | Cc1cc(-c2conc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 11801594 | 107208 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4nc(C)cnc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL290431 | 107208 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4nc(C)cnc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 10531744 | 123121 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 605 | 9 | 1 | 6 | 5.3 | Cc1cnc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL335946 | 123121 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 605 | 9 | 1 | 6 | 5.3 | Cc1cnc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 44191221 | 203016 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 398 | 4 | 0 | 5 | 5.2 | Cc1cc(-c2cncn2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL561701 | 203016 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 398 | 4 | 0 | 5 | 5.2 | Cc1cc(-c2cncn2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 10852230 | 56391 | 0 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 306 | 3 | 0 | 3 | 4.5 | Cc1cn2cccc(OCc3c(Cl)cccc3Cl)c2n1 | 10.1021/jm970591c | ||
| CHEMBL156606 | 56391 | 0 | None | - | 0 | Guinea pig | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 306 | 3 | 0 | 3 | 4.5 | Cc1cn2cccc(OCc3c(Cl)cccc3Cl)c2n1 | 10.1021/jm970591c | ||
| 10792291 | 20667 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 527 | 6 | 2 | 5 | 4.2 | CNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL1196218 | 20667 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 527 | 6 | 2 | 5 | 4.2 | CNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL556176 | 20667 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 527 | 6 | 2 | 5 | 4.2 | CNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 10769517 | 30228 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 577 | 9 | 1 | 6 | 5.1 | Cc1cnc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3C)c2n1 | 10.1021/jm980300f | ||
| CHEMBL133339 | 30228 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 577 | 9 | 1 | 6 | 5.1 | Cc1cnc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3C)c2n1 | 10.1021/jm980300f | ||
| 44214619 | 117382 | 0 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 553 | 13 | 1 | 8 | 4.7 | COC(=O)CCCCC(=O)NCC(=O)N(C)c1ccc(OC)c(COc2cccc3ccc(C)nc23)c1SC | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL325601 | 117382 | 0 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 553 | 13 | 1 | 8 | 4.7 | COC(=O)CCCCC(=O)NCC(=O)N(C)c1ccc(OC)c(COc2cccc3ccc(C)nc23)c1SC | 10.1016/s0960-894x(98)00736-7 | ||
| 44190751 | 202124 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 479 | 6 | 0 | 8 | 6.2 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Sc3nccs3)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL551758 | 202124 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 479 | 6 | 0 | 8 | 6.2 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Sc3nccs3)c2n1 | 10.1021/jm9002445 | ||
| 10721082 | 20067 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 534 | 8 | 1 | 5 | 5.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4cccnc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1191809 | 20067 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 534 | 8 | 1 | 5 | 5.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4cccnc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL542958 | 20067 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 534 | 8 | 1 | 5 | 5.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4cccnc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 10530740 | 172371 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 552 | 9 | 2 | 7 | 4.3 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ncc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| CHEMBL424268 | 172371 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 552 | 9 | 2 | 7 | 4.3 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ncc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| 10675204 | 175559 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.4 | CCn1c(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc21 | 10.1021/jm030159x | ||
| CHEMBL43746 | 175559 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.4 | CCn1c(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc21 | 10.1021/jm030159x | ||
| 10675204 | 175559 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.4 | CCn1c(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc21 | 10.1021/jm980300f | ||
| CHEMBL43746 | 175559 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.4 | CCn1c(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc21 | 10.1021/jm980300f | ||
| 10603884 | 26909 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 616 | 10 | 1 | 5 | 6.4 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)CCCc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL130438 | 26909 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 616 | 10 | 1 | 5 | 6.4 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)CCCc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 11331301 | 20059 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 663 | 13 | 3 | 7 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(NCCOC)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL1191763 | 20059 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 663 | 13 | 3 | 7 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(NCCOC)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL3215537 | 20059 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 663 | 13 | 3 | 7 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(NCCOC)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 11796407 | 54549 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 418 | 3 | 0 | 3 | 5.9 | Cc1nc2c(OCc3c(Cl)ccc(Cl)c3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| CHEMBL154823 | 54549 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 418 | 3 | 0 | 3 | 5.9 | Cc1nc2c(OCc3c(Cl)ccc(Cl)c3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| 44190942 | 203006 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 471 | 6 | 0 | 7 | 4.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Cn3ccccc3=O)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL561634 | 203006 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 471 | 6 | 0 | 7 | 4.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Cn3ccccc3=O)c2n1 | 10.1021/jm9002445 | ||
| 10032884 | 20237 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 696 | 11 | 2 | 7 | 6.9 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1193185 | 20237 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 696 | 11 | 2 | 7 | 6.9 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL544549 | 20237 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 696 | 11 | 2 | 7 | 6.9 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 10626618 | 40249 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 556 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2)cc1 | 10.1021/jm980330i | ||
| CHEMBL142015 | 40249 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 556 | 9 | 2 | 5 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2)cc1 | 10.1021/jm980330i | ||
| 10579332 | 20526 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL1195281 | 20526 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL554206 | 20526 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 44340859 | 16815 | 0 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 599 | 11 | 2 | 8 | 5.0 | COc1ccc(N(C)C(=O)CNC(=O)/C=C/c2ccc(NC(C)=O)nc2)c(SC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL115163 | 16815 | 0 | None | - | 1 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 599 | 11 | 2 | 8 | 5.0 | COc1ccc(N(C)C(=O)CNC(=O)/C=C/c2ccc(NC(C)=O)nc2)c(SC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| 11801968 | 20483 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 617 | 9 | 1 | 6 | 5.7 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1194974 | 20483 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 617 | 9 | 1 | 6 | 5.7 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL553614 | 20483 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 617 | 9 | 1 | 6 | 5.7 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)nc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 10579332 | 20526 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL1195281 | 20526 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL554206 | 20526 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 10793528 | 20242 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 588 | 8 | 1 | 5 | 5.6 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Cc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1193230 | 20242 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 588 | 8 | 1 | 5 | 5.6 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Cc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL544600 | 20242 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 588 | 8 | 1 | 5 | 5.6 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Cc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 44190581 | 202723 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 443 | 7 | 1 | 6 | 4.5 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(C)ccnc3CNC(=O)C(C)C)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL559506 | 202723 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 443 | 7 | 1 | 6 | 4.5 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(C)ccnc3CNC(=O)C(C)C)c2n1 | 10.1021/jm9002445 | ||
| 10555061 | 123744 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 568 | 10 | 1 | 5 | 6.0 | CCCCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| CHEMBL338682 | 123744 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 568 | 10 | 1 | 5 | 6.0 | CCCCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| 11181406 | 19710 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 663 | 11 | 2 | 7 | 5.7 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1OC | 10.1021/jm030326t | ||
| CHEMBL1189212 | 19710 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 663 | 11 | 2 | 7 | 5.7 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1OC | 10.1021/jm030326t | ||
| CHEMBL3217073 | 19710 | 0 | None | - | 0 | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 663 | 11 | 2 | 7 | 5.7 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cc1OC | 10.1021/jm030326t | ||
| 10769485 | 27322 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 575 | 9 | 2 | 5 | 7.2 | CNC(=O)c1ccc(/C=C/C(=O)NCc2sccc2-c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980330i | ||
| CHEMBL130775 | 27322 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 575 | 9 | 2 | 5 | 7.2 | CNC(=O)c1ccc(/C=C/C(=O)NCc2sccc2-c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | 10.1021/jm980330i | ||
| 11422667 | 19757 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 710 | 12 | 2 | 7 | 6.6 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1189575 | 19757 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 710 | 12 | 2 | 7 | 6.6 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL539023 | 19757 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 710 | 12 | 2 | 7 | 6.6 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 11158136 | 215223 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 664 | 12 | 3 | 7 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OCC(=O)O)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL99978 | 215223 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 664 | 12 | 3 | 7 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OCC(=O)O)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| 44190751 | 202124 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 479 | 6 | 0 | 8 | 6.2 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Sc3nccs3)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL551758 | 202124 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 479 | 6 | 0 | 8 | 6.2 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Sc3nccs3)c2n1 | 10.1021/jm9002445 | ||
| 44189787 | 203123 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 398 | 4 | 0 | 5 | 5.2 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL562434 | 203123 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 398 | 4 | 0 | 5 | 5.2 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 10553878 | 54404 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 513 | 6 | 0 | 6 | 4.8 | CC(=O)OCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL154682 | 54404 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 513 | 6 | 0 | 6 | 4.8 | CC(=O)OCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 10842026 | 103497 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 655 | 10 | 2 | 6 | 6.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(-c3ccccc3)n4C)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL264259 | 103497 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 655 | 10 | 2 | 6 | 6.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(-c3ccccc3)n4C)c2Cl)cc1 | 10.1021/jm980300f | ||
| 18923274 | 26597 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 604 | 9 | 1 | 6 | 5.4 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)COc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL130196 | 26597 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 604 | 9 | 1 | 6 | 5.4 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)COc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10579723 | 28089 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 617 | 7 | 2 | 6 | 5.4 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NC(=O)c4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL131380 | 28089 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 617 | 7 | 2 | 6 | 5.4 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NC(=O)c4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 44190672 | 202123 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 364 | 4 | 0 | 5 | 4.6 | Cc1cc(-c2ccnn2C)c2cccc(OCc3ccncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL551757 | 202123 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 364 | 4 | 0 | 5 | 4.6 | Cc1cc(-c2ccnn2C)c2cccc(OCc3ccncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 10722735 | 26836 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 633 | 8 | 3 | 6 | 5.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C(=O)O)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL130379 | 26836 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 633 | 8 | 3 | 6 | 5.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C(=O)O)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 22008916 | 16534 | 0 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 461 | 8 | 2 | 6 | 3.3 | CCNC(=O)NCC(=O)N(C)c1ccc(OC)c(COc2cccc3ccc(C)nc23)c1C#N | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113502 | 16534 | 0 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 461 | 8 | 2 | 6 | 3.3 | CCNC(=O)NCC(=O)N(C)c1ccc(OC)c(COc2cccc3ccc(C)nc23)c1C#N | 10.1016/s0960-894x(98)00736-7 | ||
| 44190363 | 202082 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 318 | 3 | 0 | 3 | 4.8 | Cc1ccc2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL551436 | 202082 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 318 | 3 | 0 | 3 | 4.8 | Cc1ccc2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 10575810 | 128256 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 455 | 4 | 0 | 4 | 5.3 | CC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL358234 | 128256 | 0 | None | - | 0 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 455 | 4 | 0 | 4 | 5.3 | CC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 10693220 | 54141 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 414 | 4 | 0 | 4 | 5.3 | COc1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL154465 | 54141 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 414 | 4 | 0 | 4 | 5.3 | COc1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 10651074 | 108338 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4cnc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL298463 | 108338 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4cnc(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 10651074 | 108338 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4cnc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL298463 | 108338 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4cnc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 44340951 | 16774 | 0 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 587 | 11 | 1 | 7 | 6.4 | COc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(SC)c(COc3cccc4ccc(C)nc34)c2SC)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL114915 | 16774 | 0 | None | - | 1 | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 587 | 11 | 1 | 7 | 6.4 | COc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(SC)c(COc3cccc4ccc(C)nc34)c2SC)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| 11262636 | 20609 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 721 | 16 | 2 | 8 | 5.7 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(CCOC)CCOC)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL1195841 | 20609 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 721 | 16 | 2 | 8 | 5.7 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(CCOC)CCOC)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL3215972 | 20609 | 0 | None | - | 0 | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 721 | 16 | 2 | 8 | 5.7 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(CCOC)CCOC)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 10579547 | 20348 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 603 | 8 | 2 | 5 | 5.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1194034 | 20348 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 603 | 8 | 2 | 5 | 5.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL545534 | 20348 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 603 | 8 | 2 | 5 | 5.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10650330 | 19932 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 551 | 9 | 2 | 6 | 4.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| CHEMBL1190789 | 19932 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 551 | 9 | 2 | 6 | 4.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| CHEMBL541590 | 19932 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 551 | 9 | 2 | 6 | 4.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| 44191138 | 202695 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 384 | 4 | 0 | 5 | 5.0 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL559273 | 202695 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 384 | 4 | 0 | 5 | 5.0 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 10578574 | 20355 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 548 | 7 | 1 | 6 | 3.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNS(C)(=O)=O)c3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| CHEMBL1194067 | 20355 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 548 | 7 | 1 | 6 | 3.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNS(C)(=O)=O)c3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| CHEMBL545573 | 20355 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 548 | 7 | 1 | 6 | 3.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNS(C)(=O)=O)c3Cl)cccn2c1Br | 10.1021/jm970591c | ||
| 10743570 | 53718 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 485 | 6 | 0 | 5 | 4.9 | COCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL154122 | 53718 | 0 | None | - | 0 | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 485 | 6 | 0 | 5 | 4.9 | COCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 10651074 | 108338 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4cnc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL298463 | 108338 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 591 | 9 | 2 | 6 | 5.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4cnc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 10554743 | 121932 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 552 | 9 | 2 | 7 | 3.7 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ncc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| CHEMBL334421 | 121932 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 552 | 9 | 2 | 7 | 3.7 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ncc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| 45267862 | 203099 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 434 | 5 | 0 | 7 | 4.3 | CC(=O)OCc1cncc(Cl)c1C(=O)c1cccc2c(-c3ccnn3C)cc(C)nc12 | 10.1021/jm9002445 | ||
| CHEMBL562296 | 203099 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 434 | 5 | 0 | 7 | 4.3 | CC(=O)OCc1cncc(Cl)c1C(=O)c1cccc2c(-c3ccnn3C)cc(C)nc12 | 10.1021/jm9002445 | ||
| 11227974 | 20077 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 8.1 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL1191906 | 20077 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 8.1 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL543068 | 20077 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 8.1 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(-n4cccc4CNC(=O)/C=C/c4ccc(C(=O)NCc5ccccn5)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| 11479739 | 214982 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 760 | 13 | 2 | 8 | 7.8 | Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030468n | ||
| CHEMBL98460 | 214982 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 760 | 13 | 2 | 8 | 7.8 | Cc1cc(OCc2ccccn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030468n | ||
| 10556247 | 29800 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 652 | 10 | 2 | 5 | 7.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccccc5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL133005 | 29800 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 652 | 10 | 2 | 5 | 7.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccccc5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 10394861 | 8470 | 5 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 687 | 12 | 2 | 9 | 5.5 | COc1nc2c(n1Cc1ccccn1)cccc2OCc1c(Cl)ccc(c1Cl)N(C(=O)CNC(=O)/C=C/c1ccc(nc1)NC(=O)C)C | 10.1021/jm030468n | ||
| 669 | 8470 | 5 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 687 | 12 | 2 | 9 | 5.5 | COc1nc2c(n1Cc1ccccn1)cccc2OCc1c(Cl)ccc(c1Cl)N(C(=O)CNC(=O)/C=C/c1ccc(nc1)NC(=O)C)C | 10.1021/jm030468n | ||
| CHEMBL329762 | 8470 | 5 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 687 | 12 | 2 | 9 | 5.5 | COc1nc2c(n1Cc1ccccn1)cccc2OCc1c(Cl)ccc(c1Cl)N(C(=O)CNC(=O)/C=C/c1ccc(nc1)NC(=O)C)C | 10.1021/jm030468n | ||
| 11490605 | 20523 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 634 | 10 | 2 | 7 | 5.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| CHEMBL1195242 | 20523 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 634 | 10 | 2 | 7 | 5.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| CHEMBL554127 | 20523 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 634 | 10 | 2 | 7 | 5.6 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| 44190755 | 202606 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 465 | 7 | 0 | 7 | 4.0 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3OCC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL558279 | 202606 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 465 | 7 | 0 | 7 | 4.0 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3OCC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| 44190851 | 203349 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 464 | 6 | 1 | 6 | 4.3 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CNC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL563878 | 203349 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 464 | 6 | 1 | 6 | 4.3 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CNC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| 44214214 | 20033 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 708 | 10 | 3 | 8 | 7.0 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL1191492 | 20033 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 708 | 10 | 3 | 8 | 7.0 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL542598 | 20033 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 708 | 10 | 3 | 8 | 7.0 | Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4ccc(C(=O)Nc5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| 11251046 | 19977 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 696 | 11 | 2 | 7 | 6.9 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1191121 | 19977 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 696 | 11 | 2 | 7 | 6.9 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL542173 | 19977 | 0 | None | - | 0 | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 696 | 11 | 2 | 7 | 6.9 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 44190169 | 202067 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 399 | 4 | 0 | 5 | 5.8 | Cc1cc(-c2ocnc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL551354 | 202067 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 399 | 4 | 0 | 5 | 5.8 | Cc1cc(-c2ocnc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 10746610 | 20188 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 631 | 8 | 2 | 6 | 6.3 | CC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL1192829 | 20188 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 631 | 8 | 2 | 6 | 6.3 | CC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL544132 | 20188 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 631 | 8 | 2 | 6 | 6.3 | CC(=O)c1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| 11239502 | 20475 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 674 | 11 | 2 | 6 | 6.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OC5CCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL1194911 | 20475 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 674 | 11 | 2 | 6 | 6.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OC5CCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL553530 | 20475 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 674 | 11 | 2 | 6 | 6.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OC5CCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| 10506663 | 28204 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 540 | 8 | 1 | 5 | 5.2 | CCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| CHEMBL131517 | 28204 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 540 | 8 | 1 | 5 | 5.2 | CCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| 10722735 | 26836 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 633 | 8 | 3 | 6 | 5.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C(=O)O)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL130379 | 26836 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 633 | 8 | 3 | 6 | 5.8 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Nc4cccc(C(=O)O)c4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 44190167 | 203268 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 415 | 4 | 0 | 5 | 6.3 | Cc1cc(-c2ncsc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL563391 | 203268 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 415 | 4 | 0 | 5 | 6.3 | Cc1cc(-c2ncsc2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 10895913 | 16641 | 0 | None | - | 1 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 465 | 7 | 2 | 5 | 3.9 | CCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1C#N | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL114180 | 16641 | 0 | None | - | 1 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 465 | 7 | 2 | 5 | 3.9 | CCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1C#N | 10.1016/s0960-894x(98)00736-7 | ||
| 11204664 | 118350 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 676 | 10 | 2 | 8 | 5.4 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCOCC5)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| CHEMBL328131 | 118350 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 676 | 10 | 2 | 8 | 5.4 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCOCC5)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| 9916589 | 107014 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 593 | 9 | 2 | 6 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(C)n4C)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL288603 | 107014 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 593 | 9 | 2 | 6 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(C)n4C)c2Cl)cc1 | 10.1021/jm030159x | ||
| 9916589 | 107014 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 593 | 9 | 2 | 6 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(C)n4C)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL288603 | 107014 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 593 | 9 | 2 | 6 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(C)n4C)c2Cl)cc1 | 10.1021/jm980300f | ||
| 10793528 | 20242 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 588 | 8 | 1 | 5 | 5.6 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Cc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL1193230 | 20242 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 588 | 8 | 1 | 5 | 5.6 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Cc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL544600 | 20242 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 588 | 8 | 1 | 5 | 5.6 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)Cc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10793125 | 106953 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 568 | 10 | 3 | 7 | 4.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(NC)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL288079 | 106953 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 568 | 10 | 3 | 7 | 4.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(NC)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| 10793125 | 106953 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 568 | 10 | 3 | 7 | 4.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(NC)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| CHEMBL288079 | 106953 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 568 | 10 | 3 | 7 | 4.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(NC)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| 44190077 | 203249 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 399 | 4 | 0 | 6 | 4.6 | Cc1cc(-c2ncnn2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL563254 | 203249 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 399 | 4 | 0 | 6 | 4.6 | Cc1cc(-c2ncnn2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 11468051 | 20462 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 673 | 10 | 2 | 6 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL1194820 | 20462 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 673 | 10 | 2 | 6 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL3215558 | 20462 | 0 | None | - | 0 | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 673 | 10 | 2 | 6 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 119343 | 9649 | 22 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm701575k | ||||
| 676 | 9649 | 22 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm701575k | ||||
| CHEMBL446325 | 9649 | 22 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm701575k | ||||
| 10721752 | 175997 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 569 | 10 | 2 | 7 | 3.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(OC)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL44087 | 175997 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 569 | 10 | 2 | 7 | 3.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(OC)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| 10721752 | 175997 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 569 | 10 | 2 | 7 | 3.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(OC)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| CHEMBL44087 | 175997 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 569 | 10 | 2 | 7 | 3.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(OC)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| 44190753 | 203482 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 481 | 7 | 0 | 7 | 4.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3SCC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL564841 | 203482 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 481 | 7 | 0 | 7 | 4.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3SCC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| 10580156 | 19883 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 653 | 10 | 2 | 6 | 6.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5cccnc5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1190412 | 19883 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 653 | 10 | 2 | 6 | 6.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5cccnc5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| CHEMBL540819 | 19883 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 653 | 10 | 2 | 6 | 6.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5cccnc5)cc4)c3Cl)c2n1 | 10.1021/jm980300f | ||
| 44190850 | 202002 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 463 | 7 | 1 | 6 | 4.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CNC(=O)C(C)C)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL550827 | 202002 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 463 | 7 | 1 | 6 | 4.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CNC(=O)C(C)C)c2n1 | 10.1021/jm9002445 | ||
| 10816618 | 20546 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 554 | 9 | 1 | 5 | 5.6 | CCCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL1195382 | 20546 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 554 | 9 | 1 | 5 | 5.6 | CCCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL554431 | 20546 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 554 | 9 | 1 | 5 | 5.6 | CCCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 10792967 | 85302 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 559 | 9 | 2 | 4 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NC/C=C/c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| CHEMBL2111974 | 85302 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 559 | 9 | 2 | 4 | 6.6 | CNC(=O)c1ccc(/C=C/C(=O)NC/C=C/c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm980330i | ||
| 44189791 | 203345 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 399 | 4 | 0 | 6 | 4.6 | Cc1cc(-c2nncn2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL563861 | 203345 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 399 | 4 | 0 | 6 | 4.6 | Cc1cc(-c2nncn2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 10672078 | 55058 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 469 | 5 | 0 | 4 | 5.7 | CCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL155339 | 55058 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 469 | 5 | 0 | 4 | 5.7 | CCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 11801411 | 108121 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 583 | 11 | 2 | 7 | 4.3 | CCOc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3C)cccc2n1C | 10.1021/jm030159x | ||
| CHEMBL296865 | 108121 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 583 | 11 | 2 | 7 | 4.3 | CCOc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3C)cccc2n1C | 10.1021/jm030159x | ||
| 11801411 | 108121 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 583 | 11 | 2 | 7 | 4.3 | CCOc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3C)cccc2n1C | 10.1021/jm980300f | ||
| CHEMBL296865 | 108121 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 583 | 11 | 2 | 7 | 4.3 | CCOc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3C)cccc2n1C | 10.1021/jm980300f | ||
| 10604560 | 27177 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 676 | 10 | 3 | 7 | 5.7 | COCC(=O)Nc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| CHEMBL130660 | 27177 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 676 | 10 | 3 | 7 | 5.7 | COCC(=O)Nc1cccc(NC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)c1 | 10.1021/jm980214f | ||
| 11308648 | 19807 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 736 | 11 | 2 | 7 | 7.9 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1189935 | 19807 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 736 | 11 | 2 | 7 | 7.9 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL539792 | 19807 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 736 | 11 | 2 | 7 | 7.9 | Cc1cc(N2CCCCC2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(=O)c5ccncc5)cc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 10568916 | 53442 | 0 | None | - | 0 | Guinea pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 336 | 4 | 1 | 4 | 4.0 | Cc1nc2c(OCc3c(Cl)cccc3Cl)cccn2c1CO | 10.1021/jm970591c | ||
| CHEMBL153890 | 53442 | 0 | None | - | 0 | Guinea pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 336 | 4 | 1 | 4 | 4.0 | Cc1nc2c(OCc3c(Cl)cccc3Cl)cccn2c1CO | 10.1021/jm970591c | ||
| 13825921 | 51834 | 0 | None | - | 0 | Guinea pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 374 | 6 | 0 | 4 | 4.7 | C#CCOCc1c(C)nc2c(OCc3c(Cl)cccc3Cl)cccn12 | 10.1021/jm970591c | ||
| CHEMBL152439 | 51834 | 0 | None | - | 0 | Guinea pig | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 374 | 6 | 0 | 4 | 4.7 | C#CCOCc1c(C)nc2c(OCc3c(Cl)cccc3Cl)cccn12 | 10.1021/jm970591c | ||
| 11216111 | 20062 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 648 | 12 | 2 | 6 | 6.4 | CCCOc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/jm030468n | ||
| CHEMBL1191769 | 20062 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 648 | 12 | 2 | 6 | 6.4 | CCCOc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/jm030468n | ||
| CHEMBL542911 | 20062 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 648 | 12 | 2 | 6 | 6.4 | CCCOc1cc(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc12 | 10.1021/jm030468n | ||
| 15388870 | 117410 | 0 | None | - | 1 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 543 | 8 | 1 | 6 | 6.4 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)OCc4ccccc4)c3Cl)cccc2s1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL325742 | 117410 | 0 | None | - | 1 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 543 | 8 | 1 | 6 | 6.4 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)OCc4ccccc4)c3Cl)cccc2s1 | 10.1016/s0960-894x(98)00736-7 | ||
| 10768499 | 53727 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 526 | 6 | 1 | 5 | 4.8 | CC(=O)NC(C)C(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL154130 | 53727 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 526 | 6 | 1 | 5 | 4.8 | CC(=O)NC(C)C(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 10745895 | 107932 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 585 | 10 | 2 | 7 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(SC)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL295428 | 107932 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 585 | 10 | 2 | 7 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(SC)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| 10745895 | 107932 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 585 | 10 | 2 | 7 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(SC)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| CHEMBL295428 | 107932 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 585 | 10 | 2 | 7 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(SC)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| 11158089 | 19689 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 620 | 10 | 2 | 6 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OC)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL1189084 | 19689 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 620 | 10 | 2 | 6 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OC)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| CHEMBL538022 | 19689 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 620 | 10 | 2 | 6 | 5.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(OC)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030468n | ||
| 11479294 | 20596 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 648 | 10 | 1 | 7 | 5.4 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)nc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL1195758 | 20596 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 648 | 10 | 1 | 7 | 5.4 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)nc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| CHEMBL3216404 | 20596 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 648 | 10 | 1 | 7 | 5.4 | Cc1cc(N(C)C)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)nc4)c3Cl)c2n1 | 10.1021/jm030326t | ||
| 44190852 | 202185 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 465 | 6 | 0 | 7 | 4.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3COC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL552090 | 202185 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 465 | 6 | 0 | 7 | 4.8 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3COC(=O)N(C)C)c2n1 | 10.1021/jm9002445 | ||
| 10578612 | 20504 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 551 | 9 | 2 | 6 | 4.9 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| CHEMBL1195105 | 20504 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 551 | 9 | 2 | 6 | 4.9 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| CHEMBL553843 | 20504 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 551 | 9 | 2 | 6 | 4.9 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cn1 | 10.1021/jm980300f | ||
| 10769383 | 29637 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 570 | 10 | 2 | 8 | 3.9 | COc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3C)cccc2n1C | 10.1021/jm980300f | ||
| CHEMBL132860 | 29637 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 570 | 10 | 2 | 8 | 3.9 | COc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3C)cccc2n1C | 10.1021/jm980300f | ||
| 10841393 | 20055 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.2 | CCc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc2n1C | 10.1021/jm980300f | ||
| CHEMBL1191700 | 20055 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.2 | CCc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc2n1C | 10.1021/jm980300f | ||
| CHEMBL542836 | 20055 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.2 | CCc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc2n1C | 10.1021/jm980300f | ||
| 25019714 | 203362 | 2 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 519 | 6 | 1 | 6 | 5.8 | Cc1cc(-c2[nH]ncc2C)c2cccc(OCc3c(C)ccnc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL563956 | 203362 | 2 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 519 | 6 | 1 | 6 | 5.8 | Cc1cc(-c2[nH]ncc2C)c2cccc(OCc3c(C)ccnc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | 10.1021/jm9002445 | ||
| 10841393 | 20055 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.2 | CCc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc2n1C | 10.1021/jm030159x | ||
| CHEMBL1191700 | 20055 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.2 | CCc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc2n1C | 10.1021/jm030159x | ||
| CHEMBL542836 | 20055 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.2 | CCc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc2n1C | 10.1021/jm030159x | ||
| 44191040 | 202763 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 519 | 6 | 0 | 7 | 5.5 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(C)ccnc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL559825 | 202763 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 519 | 6 | 0 | 7 | 5.5 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(C)ccnc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | 10.1021/jm9002445 | ||
| 10675204 | 175559 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.4 | CCn1c(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc21 | 10.1021/jm980300f | ||
| CHEMBL43746 | 175559 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.4 | CCn1c(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc21 | 10.1021/jm980300f | ||
| 10603884 | 26909 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 616 | 10 | 1 | 5 | 6.4 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)CCCc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL130438 | 26909 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 616 | 10 | 1 | 5 | 6.4 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)CCCc4ccccc4)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 10506663 | 28204 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 540 | 8 | 1 | 5 | 5.2 | CCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| CHEMBL131517 | 28204 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 540 | 8 | 1 | 5 | 5.2 | CCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| 10506663 | 28204 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 540 | 8 | 1 | 5 | 5.2 | CCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL131517 | 28204 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 540 | 8 | 1 | 5 | 5.2 | CCCC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 10675204 | 175559 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.4 | CCn1c(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc21 | 10.1021/jm030159x | ||
| CHEMBL43746 | 175559 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 607 | 10 | 2 | 6 | 5.4 | CCn1c(C)nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3Cl)cccc21 | 10.1021/jm030159x | ||
| 44190267 | 201915 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 401 | 4 | 0 | 5 | 5.9 | Cc1cc(-c2cscn2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL550143 | 201915 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 401 | 4 | 0 | 5 | 5.9 | Cc1cc(-c2cscn2)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 44341060 | 16332 | 0 | None | - | 1 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 539 | 10 | 1 | 6 | 5.2 | COc1ccc(N(C)C(=O)CNC(=O)/C=C/c2cccc(C)c2)c(OC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL112360 | 16332 | 0 | None | - | 1 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 539 | 10 | 1 | 6 | 5.2 | COc1ccc(N(C)C(=O)CNC(=O)/C=C/c2cccc(C)c2)c(OC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| 10625996 | 127786 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 526 | 7 | 1 | 5 | 4.8 | CC(=O)NCCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL356480 | 127786 | 0 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 526 | 7 | 1 | 5 | 4.8 | CC(=O)NCCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 10651301 | 123306 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 603 | 7 | 2 | 5 | 6.4 | Cc1ccccc1NC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| CHEMBL336209 | 123306 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 603 | 7 | 2 | 5 | 6.4 | Cc1ccccc1NC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| 10840534 | 29345 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 555 | 8 | 1 | 6 | 3.9 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)CN(C)C)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| CHEMBL132620 | 29345 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 555 | 8 | 1 | 6 | 3.9 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)CN(C)C)c3Cl)cccn2c1Br | 10.1021/jm980214f | ||
| 11433935 | 19978 | 1 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 687 | 10 | 2 | 6 | 7.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCCCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL1191123 | 19978 | 1 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 687 | 10 | 2 | 6 | 7.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCCCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL3215986 | 19978 | 1 | None | - | 0 | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 687 | 10 | 2 | 6 | 7.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCCCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 10603982 | 86860 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 625 | 12 | 2 | 8 | 4.0 | CCOC(=O)Cc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3C)cccc2n1C | 10.1021/jm030159x | ||
| CHEMBL21311 | 86860 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 625 | 12 | 2 | 8 | 4.0 | CCOC(=O)Cc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3C)cccc2n1C | 10.1021/jm030159x | ||
| 10603982 | 86860 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 625 | 12 | 2 | 8 | 4.0 | CCOC(=O)Cc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3C)cccc2n1C | 10.1021/jm980300f | ||
| CHEMBL21311 | 86860 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 625 | 12 | 2 | 8 | 4.0 | CCOC(=O)Cc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3C)cccc2n1C | 10.1021/jm980300f | ||
| 11456652 | 19979 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 676 | 10 | 2 | 8 | 4.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCOCC5)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| CHEMBL1191124 | 19979 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 676 | 10 | 2 | 8 | 4.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCOCC5)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| CHEMBL542176 | 19979 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 676 | 10 | 2 | 8 | 4.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCOCC5)cc(C)nc34)c2Cl)cn1 | 10.1021/jm030326t | ||
| 10579143 | 175243 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 580 | 9 | 2 | 6 | 5.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4oc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL43510 | 175243 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 580 | 9 | 2 | 6 | 5.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4oc(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 44323787 | 19788 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 659 | 10 | 2 | 6 | 6.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL1189812 | 19788 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 659 | 10 | 2 | 6 | 6.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL3215529 | 19788 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 659 | 10 | 2 | 6 | 6.2 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCCC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 10840241 | 123247 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 541 | 7 | 2 | 5 | 4.6 | CCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| CHEMBL336116 | 123247 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 541 | 7 | 2 | 5 | 4.6 | CCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm980214f | ||
| 10840241 | 123247 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 541 | 7 | 2 | 5 | 4.6 | CCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| CHEMBL336116 | 123247 | 0 | None | - | 0 | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 541 | 7 | 2 | 5 | 4.6 | CCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccn3c(Br)c(C)nc23)c1Cl | 10.1021/jm970591c | ||
| 11802476 | 19736 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL1189415 | 19736 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL538732 | 19736 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm030159x | ||
| 11802476 | 19736 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL1189415 | 19736 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL538732 | 19736 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 657 | 9 | 2 | 6 | 5.4 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1 | 10.1021/jm980300f | ||
| 9916589 | 107014 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 593 | 9 | 2 | 6 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(C)n4C)c2Cl)cc1 | 10.1021/jm980300f | ||
| CHEMBL288603 | 107014 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 593 | 9 | 2 | 6 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(C)n4C)c2Cl)cc1 | 10.1021/jm980300f | ||
| 11802489 | 20505 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 658 | 9 | 2 | 7 | 4.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cn1 | 10.1021/jm980214f | ||
| CHEMBL1195106 | 20505 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 658 | 9 | 2 | 7 | 4.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cn1 | 10.1021/jm980214f | ||
| CHEMBL553844 | 20505 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 658 | 9 | 2 | 7 | 4.8 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cn1 | 10.1021/jm980214f | ||
| 11490839 | 19941 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 671 | 10 | 1 | 8 | 5.5 | Cc1cc(-n2ccnn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL1190878 | 19941 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 671 | 10 | 1 | 8 | 5.5 | Cc1cc(-n2ccnn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| CHEMBL541805 | 19941 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 671 | 10 | 1 | 8 | 5.5 | Cc1cc(-n2ccnn2)c2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm030159x | ||
| 9916589 | 107014 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 593 | 9 | 2 | 6 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(C)n4C)c2Cl)cc1 | 10.1021/jm030159x | ||
| CHEMBL288603 | 107014 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 593 | 9 | 2 | 6 | 4.9 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(C)n4C)c2Cl)cc1 | 10.1021/jm030159x | ||
| 10674687 | 20399 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 576 | 9 | 1 | 5 | 5.7 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3C)c2n1 | 10.1021/jm980300f | ||
| CHEMBL1194363 | 20399 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 576 | 9 | 1 | 5 | 5.7 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3C)c2n1 | 10.1021/jm980300f | ||
| CHEMBL552543 | 20399 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 576 | 9 | 1 | 5 | 5.7 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(N5CCCC5=O)cc4)c3C)c2n1 | 10.1021/jm980300f | ||
| 10745895 | 107932 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 585 | 10 | 2 | 7 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(SC)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| CHEMBL295428 | 107932 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 585 | 10 | 2 | 7 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(SC)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| 10745895 | 107932 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 585 | 10 | 2 | 7 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(SC)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL295428 | 107932 | 0 | None | - | 0 | Guinea pig | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 585 | 10 | 2 | 7 | 4.6 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(SC)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| 11801411 | 108121 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 583 | 11 | 2 | 7 | 4.3 | CCOc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3C)cccc2n1C | 10.1021/jm980300f | ||
| CHEMBL296865 | 108121 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 583 | 11 | 2 | 7 | 4.3 | CCOc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3C)cccc2n1C | 10.1021/jm980300f | ||
| 44191223 | 203046 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 4 | 0 | 5 | 5.2 | Cc1cc(-c2nccn2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL561899 | 203046 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 4 | 0 | 5 | 5.2 | Cc1cc(-c2nccn2C)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| 11801411 | 108121 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 583 | 11 | 2 | 7 | 4.3 | CCOc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3C)cccc2n1C | 10.1021/jm030159x | ||
| CHEMBL296865 | 108121 | 0 | None | - | 0 | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 583 | 11 | 2 | 7 | 4.3 | CCOc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)NC)cc4)c3C)cccc2n1C | 10.1021/jm030159x | ||
| 10627129 | 108323 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 583 | 11 | 2 | 7 | 4.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(COC)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL298320 | 108323 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 583 | 11 | 2 | 7 | 4.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(COC)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| 10627129 | 108323 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 583 | 11 | 2 | 7 | 4.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(COC)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| CHEMBL298320 | 108323 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 583 | 11 | 2 | 7 | 4.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(COC)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| 10793125 | 106953 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 568 | 10 | 3 | 7 | 4.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(NC)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| CHEMBL288079 | 106953 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 568 | 10 | 3 | 7 | 4.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(NC)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| 10793125 | 106953 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 568 | 10 | 3 | 7 | 4.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(NC)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL288079 | 106953 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 568 | 10 | 3 | 7 | 4.0 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(NC)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| 10555263 | 107873 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 581 | 10 | 2 | 7 | 4.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(C(C)=O)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| CHEMBL295005 | 107873 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 581 | 10 | 2 | 7 | 4.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(C(C)=O)n4C)c2C)cc1 | 10.1021/jm030159x | ||
| 10626599 | 37760 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 555 | 8 | 2 | 4 | 7.4 | CNC(=O)c1ccc(/C=C/C(=O)Nc2cccc(-c3ccc(C)c(COc4cccc5ccc(C)nc45)c3C)c2)cc1 | 10.1021/jm980330i | ||
| CHEMBL139870 | 37760 | 0 | None | - | 0 | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 555 | 8 | 2 | 4 | 7.4 | CNC(=O)c1ccc(/C=C/C(=O)Nc2cccc(-c3ccc(C)c(COc4cccc5ccc(C)nc45)c3C)c2)cc1 | 10.1021/jm980330i | ||
| 10555263 | 107873 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 581 | 10 | 2 | 7 | 4.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(C(C)=O)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| CHEMBL295005 | 107873 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 581 | 10 | 2 | 7 | 4.1 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(C(C)=O)n4C)c2C)cc1 | 10.1021/jm980300f | ||
| 11239381 | 19916 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 688 | 10 | 2 | 7 | 5.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCN(C)CC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL1190638 | 19916 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 688 | 10 | 2 | 7 | 5.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCN(C)CC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| CHEMBL3215541 | 19916 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 688 | 10 | 2 | 7 | 5.3 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N5CCN(C)CC5)cc(C)nc34)c2Cl)cc1 | 10.1021/jm030326t | ||
| 44190266 | 202235 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 435 | 4 | 0 | 5 | 6.6 | Cc1cc(-c2scnc2Cl)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL552442 | 202235 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 435 | 4 | 0 | 5 | 6.6 | Cc1cc(-c2scnc2Cl)c2cccc(OCc3c(Cl)cncc3Cl)c2n1 | 10.1021/jm9002445 | ||
| CHEMBL5274928 | 200610 | 0 | None | - | 1 | Human | 9.4 | pKd | = | 9.4 | Binding | ChEMBL | 1290 | 30 | 18 | 17 | -4.8 | N=C(N)NCCCC(NC(=O)[C@@H]1C[C@@H]2CCC[C@@H]2N1C(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1cccs1)NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.6b01029 | ||
| CHEMBL5280457 | 200847 | 0 | None | - | 1 | Human | 9.1 | pKd | = | 9.1 | Binding | ChEMBL | 1312 | 30 | 18 | 17 | -4.6 | N=C(N)NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.6b01029 | ||
| 44317520 | 111666 | 0 | None | - | 1 | Human | 4.9 | pKd | = | 4.9 | Binding | ChEMBL | 601 | 12 | 5 | 5 | 3.6 | N=C(N)NCC1N=C(c2ccccc2)c2cc(N(Cc3ccccc3)Cc3ccccc3)ccc2N(CCCN=C(N)N)C1=O | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL311191 | 111666 | 0 | None | - | 1 | Human | 4.9 | pKd | = | 4.9 | Binding | ChEMBL | 601 | 12 | 5 | 5 | 3.6 | N=C(N)NCC1N=C(c2ccccc2)c2cc(N(Cc3ccccc3)Cc3ccccc3)ccc2N(CCCN=C(N)N)C1=O | 10.1016/s0960-894x(00)00482-0 | ||
| 44317577 | 212424 | 0 | None | - | 1 | Human | 4.9 | pKd | = | 4.9 | Binding | ChEMBL | 382 | 9 | 2 | 4 | 5.2 | CCCCC1(CCCC)Oc2cccc(NC(=O)c3ccc(CN)cc3)c2O1 | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL81864 | 212424 | 0 | None | - | 1 | Human | 4.9 | pKd | = | 4.9 | Binding | ChEMBL | 382 | 9 | 2 | 4 | 5.2 | CCCCC1(CCCC)Oc2cccc(NC(=O)c3ccc(CN)cc3)c2O1 | 10.1016/s0960-894x(00)00482-0 | ||
| 44317502 | 212512 | 0 | None | - | 1 | Human | 4.9 | pKd | = | 4.9 | Binding | ChEMBL | 439 | 12 | 2 | 5 | 5.0 | CCCCC1(CCCC)Oc2cccc(N(CCCN)C(=O)c3ccc(CN)cc3)c2O1 | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL82600 | 212512 | 0 | None | - | 1 | Human | 4.9 | pKd | = | 4.9 | Binding | ChEMBL | 439 | 12 | 2 | 5 | 5.0 | CCCCC1(CCCC)Oc2cccc(N(CCCN)C(=O)c3ccc(CN)cc3)c2O1 | 10.1016/s0960-894x(00)00482-0 | ||
| 44317490 | 111473 | 0 | None | - | 1 | Human | 4.8 | pKd | = | 4.8 | Binding | ChEMBL | 402 | 6 | 3 | 3 | 3.1 | N=C(N)NC[C@H]1C[C@@H](OCc2ccccc2)CN1C(=O)c1ccc2ccccc2c1 | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL310531 | 111473 | 0 | None | - | 1 | Human | 4.8 | pKd | = | 4.8 | Binding | ChEMBL | 402 | 6 | 3 | 3 | 3.1 | N=C(N)NC[C@H]1C[C@@H](OCc2ccccc2)CN1C(=O)c1ccc2ccccc2c1 | 10.1016/s0960-894x(00)00482-0 | ||
| 44317519 | 112516 | 0 | None | - | 1 | Human | 4.8 | pKd | = | 4.8 | Binding | ChEMBL | 531 | 11 | 2 | 5 | 5.1 | NCCCN1C(=O)C(CCN)N=C(c2ccccc2)c2cc(N(Cc3ccccc3)Cc3ccccc3)ccc21 | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL312658 | 112516 | 0 | None | - | 1 | Human | 4.8 | pKd | = | 4.8 | Binding | ChEMBL | 531 | 11 | 2 | 5 | 5.1 | NCCCN1C(=O)C(CCN)N=C(c2ccccc2)c2cc(N(Cc3ccccc3)Cc3ccccc3)ccc21 | 10.1016/s0960-894x(00)00482-0 | ||
| 44317631 | 111902 | 0 | None | - | 1 | Human | 4.8 | pKd | = | 4.8 | Binding | ChEMBL | 501 | 11 | 4 | 5 | 3.7 | NCc1ccc(CNC(=O)[C@@H](CN)n2cccc2CNC(=O)C(c2ccccc2)C2CCCCC2)cc1 | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL311420 | 111902 | 0 | None | - | 1 | Human | 4.8 | pKd | = | 4.8 | Binding | ChEMBL | 501 | 11 | 4 | 5 | 3.7 | NCc1ccc(CNC(=O)[C@@H](CN)n2cccc2CNC(=O)C(c2ccccc2)C2CCCCC2)cc1 | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL5268547 | 200349 | 0 | None | - | 1 | Human | 5.7 | pKd | = | 5.7 | Binding | ChEMBL | 1250 | 30 | 18 | 17 | -5.6 | N=C(N)NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@]12Cc1ccccc1CN(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C2=O | 10.1021/acs.jmedchem.6b01029 | ||
| 73351522 | 96164 | 0 | None | - | 1 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 861 | 10 | 7 | 9 | 0.9 | NCCCC[C@@H]1NC(=O)[C@H](c2ccccc2)NC(=O)[C@H](CNC(=O)Cc2ccccc2)NC(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H](CN)NC1=O | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL2369879 | 96164 | 0 | None | - | 1 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 861 | 10 | 7 | 9 | 0.9 | NCCCC[C@@H]1NC(=O)[C@H](c2ccccc2)NC(=O)[C@H](CNC(=O)Cc2ccccc2)NC(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H](CN)NC1=O | 10.1016/s0960-894x(00)00482-0 | ||
| 90662959 | 113364 | 0 | None | - | 1 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 769 | 8 | 7 | 7 | 1.6 | N=C(N)NCCC[C@@H]1NC(=O)N2C3CCCCC3C[C@H]2C(=O)N2Cc3ccccc3C[C@@H]2C(=O)NCC[C@@H](NC(=O)CCc2ccccc2)C(=O)CCNC1=O | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL3142416 | 113364 | 0 | None | - | 1 | Human | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 769 | 8 | 7 | 7 | 1.6 | N=C(N)NCCC[C@@H]1NC(=O)N2C3CCCCC3C[C@H]2C(=O)N2Cc3ccccc3C[C@@H]2C(=O)NCC[C@@H](NC(=O)CCc2ccccc2)C(=O)CCNC1=O | 10.1016/s0960-894x(00)00482-0 | ||
| 44317544 | 212467 | 0 | None | - | 1 | Human | 4.6 | pKd | = | 4.6 | Binding | ChEMBL | 471 | 18 | 1 | 3 | 7.6 | CCCCc1ccnc([C@H](CC2CCCCC2)NC(=O)CCCCN(CCCC)CCCC)c1 | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL82249 | 212467 | 0 | None | - | 1 | Human | 4.6 | pKd | = | 4.6 | Binding | ChEMBL | 471 | 18 | 1 | 3 | 7.6 | CCCCc1ccnc([C@H](CC2CCCCC2)NC(=O)CCCCN(CCCC)CCCC)c1 | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL5266183 | 200251 | 0 | None | - | 1 | Human | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 1210 | 31 | 19 | 17 | -6.4 | N=C(N)NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@@H]1Cc2ccccc2CN(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C1=O | 10.1021/acs.jmedchem.6b01029 | ||
| CHEMBL5271423 | 200462 | 0 | None | - | 1 | Human | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 1312 | 30 | 18 | 17 | -4.6 | N=C(N)NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.6b01029 | ||
| 44317810 | 112407 | 0 | None | - | 1 | Human | 4.6 | pKd | = | 4.6 | Binding | ChEMBL | 537 | 14 | 4 | 5 | 4.6 | NCCCC[C@H](C(=O)NCc1ccc(CN)cc1)n1cccc1C(=O)NC(Cc1ccccc1)c1ccccc1 | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL312374 | 112407 | 0 | None | - | 1 | Human | 4.6 | pKd | = | 4.6 | Binding | ChEMBL | 537 | 14 | 4 | 5 | 4.6 | NCCCC[C@H](C(=O)NCc1ccc(CN)cc1)n1cccc1C(=O)NC(Cc1ccccc1)c1ccccc1 | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL5267275 | 200294 | 0 | None | - | 1 | Human | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 1250 | 30 | 18 | 17 | -5.6 | N=C(N)NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@]12Cc1ccccc1CN(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C2=O | 10.1021/acs.jmedchem.6b01029 | ||
| 90663066 | 113365 | 0 | None | - | 1 | Guinea pig | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 1081 | 34 | 14 | 12 | -0.5 | N=C(N)NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1CCc2ccccc2[C@@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1016/S0960-894X(97)10042-7 | ||
| CHEMBL3142595 | 113365 | 0 | None | - | 1 | Guinea pig | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 1081 | 34 | 14 | 12 | -0.5 | N=C(N)NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1CCc2ccccc2[C@@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1016/S0960-894X(97)10042-7 | ||
| CHEMBL5274916 | 200608 | 0 | None | - | 1 | Human | 5.4 | pKd | = | 5.4 | Binding | ChEMBL | 1405 | 31 | 20 | 19 | -4.2 | N=C(N)NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/acs.jmedchem.6b01029 | ||
| 10481702 | 111182 | 0 | None | - | 1 | Human | 5.4 | pKd | = | 5.4 | Binding | ChEMBL | 517 | 10 | 2 | 5 | 4.8 | NCCCN1C(=O)C(CN)N=C(c2ccccc2)c2cc(N(Cc3ccccc3)Cc3ccccc3)ccc21 | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL310300 | 111182 | 0 | None | - | 1 | Human | 5.4 | pKd | = | 5.4 | Binding | ChEMBL | 517 | 10 | 2 | 5 | 4.8 | NCCCN1C(=O)C(CN)N=C(c2ccccc2)c2cc(N(Cc3ccccc3)Cc3ccccc3)ccc21 | 10.1016/s0960-894x(00)00482-0 | ||
| 10371624 | 112201 | 0 | None | - | 1 | Human | 5.4 | pKd | = | 5.4 | Binding | ChEMBL | 615 | 13 | 5 | 5 | 4.0 | N=C(N)NCCC1N=C(c2ccccc2)c2cc(N(Cc3ccccc3)Cc3ccccc3)ccc2N(CCCN=C(N)N)C1=O | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL311969 | 112201 | 0 | None | - | 1 | Human | 5.4 | pKd | = | 5.4 | Binding | ChEMBL | 615 | 13 | 5 | 5 | 4.0 | N=C(N)NCCC1N=C(c2ccccc2)c2cc(N(Cc3ccccc3)Cc3ccccc3)ccc2N(CCCN=C(N)N)C1=O | 10.1016/s0960-894x(00)00482-0 | ||
| 44317826 | 212054 | 0 | None | - | 1 | Human | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 435 | 10 | 3 | 3 | 4.6 | CCCCc1ccnc([C@H](CC2CCCCC2)NC(=O)c2ccc(CN=C(N)N)cc2)c1 | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL79057 | 212054 | 0 | None | - | 1 | Human | 5.3 | pKd | = | 5.3 | Binding | ChEMBL | 435 | 10 | 3 | 3 | 4.6 | CCCCc1ccnc([C@H](CC2CCCCC2)NC(=O)c2ccc(CN=C(N)N)cc2)c1 | 10.1016/s0960-894x(00)00482-0 | ||
| 44317458 | 211976 | 0 | None | - | 1 | Human | 4.2 | pKd | = | 4.2 | Binding | ChEMBL | 359 | 11 | 2 | 3 | 4.7 | CCCCc1ccnc([C@H](CC2CCCCC2)NC(=O)CCCCN)c1 | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL78487 | 211976 | 0 | None | - | 1 | Human | 4.2 | pKd | = | 4.2 | Binding | ChEMBL | 359 | 11 | 2 | 3 | 4.7 | CCCCc1ccnc([C@H](CC2CCCCC2)NC(=O)CCCCN)c1 | 10.1016/s0960-894x(00)00482-0 | ||
| 44317602 | 212456 | 0 | None | - | 1 | Human | 4.2 | pKd | = | 4.2 | Binding | ChEMBL | 360 | 5 | 1 | 3 | 3.6 | NC[C@H]1C[C@@H](OCc2ccccc2)CN1C(=O)c1ccc2ccccc2c1 | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL82194 | 212456 | 0 | None | - | 1 | Human | 4.2 | pKd | = | 4.2 | Binding | ChEMBL | 360 | 5 | 1 | 3 | 3.6 | NC[C@H]1C[C@@H](OCc2ccccc2)CN1C(=O)c1ccc2ccccc2c1 | 10.1016/s0960-894x(00)00482-0 | ||
| 44317543 | 112102 | 0 | None | - | 1 | Human | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 393 | 9 | 2 | 3 | 5.3 | CCCCc1ccnc([C@H](CC2CCCCC2)NC(=O)c2ccc(CN)cc2)c1 | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL311593 | 112102 | 0 | None | - | 1 | Human | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 393 | 9 | 2 | 3 | 5.3 | CCCCc1ccnc([C@H](CC2CCCCC2)NC(=O)c2ccc(CN)cc2)c1 | 10.1016/s0960-894x(00)00482-0 | ||
| 44317849 | 110679 | 0 | None | - | 1 | Human | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 434 | 7 | 1 | 3 | 5.6 | NCc1cccc(Cn2ccc3c2C(=O)C(Cc2ccccc2)(Cc2ccccc2)CC3)c1 | 10.1016/s0960-894x(00)00482-0 | ||
| CHEMBL309221 | 110679 | 0 | None | - | 1 | Human | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 434 | 7 | 1 | 3 | 5.6 | NCc1cccc(Cn2ccc3c2C(=O)C(Cc2ccccc2)(Cc2ccccc2)CC3)c1 | 10.1016/s0960-894x(00)00482-0 | ||
| 11050762 | 74449 | 0 | None | 5248 | 2 | Rat | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 696 | 16 | 4 | 9 | 3.7 | CN(C)CCCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(N/N=C(\S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL1907651 | 74449 | 0 | None | 5248 | 2 | Rat | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 696 | 16 | 4 | 9 | 3.7 | CN(C)CCCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(N/N=C(\S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 667 | 8754 | 37 | None | -1 | 6 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2006.01.125 | ||||
| 6918173 | 8754 | 37 | None | -1 | 6 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2006.01.125 | ||||
| 71364 | 8754 | 37 | None | -1 | 6 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2006.01.125 | ||||
| CHEMBL2028850 | 8754 | 37 | None | -1 | 6 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2006.01.125 | ||||
| DB06196 | 8754 | 37 | None | -1 | 6 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2006.01.125 | ||||
| 57398326 | 78419 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 763 | 14 | 1 | 6 | 6.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956864 | 78419 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 763 | 14 | 1 | 6 | 6.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963558 | 78419 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 763 | 14 | 1 | 6 | 6.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57401774 | 78368 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 749 | 13 | 1 | 6 | 5.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956863 | 78368 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 749 | 13 | 1 | 6 | 5.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963184 | 78368 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 749 | 13 | 1 | 6 | 5.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57391279 | 78369 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 748 | 14 | 2 | 7 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CNCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956876 | 78369 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 748 | 14 | 2 | 7 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CNCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963185 | 78369 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 748 | 14 | 2 | 7 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CNCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57394782 | 78418 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 720 | 11 | 3 | 9 | 3.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCN)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956855 | 78418 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 720 | 11 | 3 | 9 | 3.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCN)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963557 | 78418 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 720 | 11 | 3 | 9 | 3.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCN)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57403503 | 78440 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 748 | 12 | 2 | 9 | 3.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCN(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956856 | 78440 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 748 | 12 | 2 | 9 | 3.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCN(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963651 | 78440 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 748 | 12 | 2 | 9 | 3.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCN(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 11498853 | 89963 | 13 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 763 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL218427 | 89963 | 13 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 763 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL541758 | 89963 | 13 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 763 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 11498853 | 89963 | 13 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 763 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL218427 | 89963 | 13 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 763 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL541758 | 89963 | 13 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 763 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 11600324 | 148774 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 747 | 12 | 2 | 7 | 4.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL387452 | 148774 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 747 | 12 | 2 | 7 | 4.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 16105746 | 168709 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 779 | 12 | 2 | 8 | 4.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCSCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL415366 | 168709 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 779 | 12 | 2 | 8 | 4.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCSCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 667 | 8754 | 37 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901531 | ||||
| 6918173 | 8754 | 37 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901531 | ||||
| 71364 | 8754 | 37 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901531 | ||||
| CHEMBL2028850 | 8754 | 37 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901531 | ||||
| DB06196 | 8754 | 37 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901531 | ||||
| 57399981 | 78349 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 762 | 13 | 2 | 9 | 4.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956858 | 78349 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 762 | 13 | 2 | 9 | 4.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963148 | 78349 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 762 | 13 | 2 | 9 | 4.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57401778 | 78353 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 748 | 14 | 1 | 7 | 6.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(CCCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956870 | 78353 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 748 | 14 | 1 | 7 | 6.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(CCCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963152 | 78353 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 748 | 14 | 1 | 7 | 6.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(CCCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57390466 | 78415 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 776 | 13 | 5 | 9 | 3.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCNC(=N)N)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956719 | 78415 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 776 | 13 | 5 | 9 | 3.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCNC(=N)N)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963540 | 78415 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 776 | 13 | 5 | 9 | 3.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCNC(=N)N)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 667 | 8754 | 37 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| 6918173 | 8754 | 37 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| 71364 | 8754 | 37 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| CHEMBL2028850 | 8754 | 37 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| DB06196 | 8754 | 37 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| 3812 | 7504 | 42 | None | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901531 | ||||
| 439201 | 7504 | 42 | None | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901531 | ||||
| 649 | 7504 | 42 | None | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901531 | ||||
| CHEMBL406291 | 7504 | 42 | None | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901531 | ||||
| DB12126 | 7504 | 42 | None | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901531 | ||||
| 44355428 | 175913 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 1200 | 31 | 15 | 18 | -5.4 | NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)NC1CSc2ccccc2N(CC(=O)N[C@H](CCCN=C(N)N)C(=O)O)C1=O | 10.1021/jm9901531 | ||
| CHEMBL440257 | 175913 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 1200 | 31 | 15 | 18 | -5.4 | NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)NC1CSc2ccccc2N(CC(=O)N[C@H](CCCN=C(N)N)C(=O)O)C1=O | 10.1021/jm9901531 | ||
| 667 | 8754 | 37 | None | -1 | 6 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| 6918173 | 8754 | 37 | None | -1 | 6 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| 71364 | 8754 | 37 | None | -1 | 6 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| CHEMBL2028850 | 8754 | 37 | None | -1 | 6 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| DB06196 | 8754 | 37 | None | -1 | 6 | Rat | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| 57399228 | 78347 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 706 | 9 | 1 | 7 | 3.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956720 | 78347 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 706 | 9 | 1 | 7 | 3.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963146 | 78347 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 706 | 9 | 1 | 7 | 3.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57398324 | 78360 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 735 | 12 | 1 | 6 | 5.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956862 | 78360 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 735 | 12 | 1 | 6 | 5.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963164 | 78360 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 735 | 12 | 1 | 6 | 5.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57345657 | 78367 | 0 | None | -2 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 748 | 12 | 1 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956722 | 78367 | 0 | None | -2 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 748 | 12 | 1 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963183 | 78367 | 0 | None | -2 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 748 | 12 | 1 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57396534 | 78439 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 705 | 11 | 2 | 8 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCN)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956854 | 78439 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 705 | 11 | 2 | 8 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCN)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963650 | 78439 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 705 | 11 | 2 | 8 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCN)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 16105703 | 143258 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 776 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCN(C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL373607 | 143258 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 776 | 12 | 2 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCN(C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 90662945 | 113363 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 1298 | 30 | 15 | 17 | -5.2 | NC(N)=NCCC[C@H](N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1c2ccccc2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm990961s | ||
| CHEMBL3142396 | 113363 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 1298 | 30 | 15 | 17 | -5.2 | NC(N)=NCCC[C@H](N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1c2ccccc2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm990961s | ||
| CHEMBL2371961 | 216937 | 0 | None | - | 1 | Guinea pig | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@@H]1CN(C(=O)[C@H]2c3ccccc3CCN2C(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C2CCCCC21)C(=O)O | 10.1021/jm00069a016 | ||||
| 57401770 | 78358 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 733 | 12 | 1 | 8 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCN(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956853 | 78358 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 733 | 12 | 1 | 8 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCN(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963162 | 78358 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 733 | 12 | 1 | 8 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCN(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57401772 | 78363 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 734 | 12 | 3 | 9 | 3.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956857 | 78363 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 734 | 12 | 3 | 9 | 3.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963175 | 78363 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 734 | 12 | 3 | 9 | 3.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57396538 | 78364 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 721 | 11 | 1 | 6 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956861 | 78364 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 721 | 11 | 1 | 6 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963176 | 78364 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 721 | 11 | 1 | 6 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 16105734 | 91047 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 803 | 14 | 4 | 7 | 4.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCCNC(=N)N)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL221285 | 91047 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 803 | 14 | 4 | 7 | 4.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCCNC(=N)N)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 9831859 | 16478 | 0 | None | - | 1 | Guinea pig | 10.0 | pKi | = | 10 | Binding | ChEMBL | 508 | 10 | 3 | 6 | 3.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCCCCN)c3C#N)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113169 | 16478 | 0 | None | - | 1 | Guinea pig | 10.0 | pKi | = | 10 | Binding | ChEMBL | 508 | 10 | 3 | 6 | 3.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCCCCN)c3C#N)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| 10257108 | 16603 | 1 | None | - | 1 | Guinea pig | 10.0 | pKi | = | 10 | Binding | ChEMBL | 554 | 9 | 1 | 6 | 5.4 | COc1cccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2C#N)c1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113963 | 16603 | 1 | None | - | 1 | Guinea pig | 10.0 | pKi | = | 10 | Binding | ChEMBL | 554 | 9 | 1 | 6 | 5.4 | COc1cccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2C#N)c1 | 10.1016/s0960-894x(98)00736-7 | ||
| 3812 | 7504 | 42 | None | 1 | 6 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990961s | ||||
| 439201 | 7504 | 42 | None | 1 | 6 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990961s | ||||
| 649 | 7504 | 42 | None | 1 | 6 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990961s | ||||
| CHEMBL406291 | 7504 | 42 | None | 1 | 6 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990961s | ||||
| DB12126 | 7504 | 42 | None | 1 | 6 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990961s | ||||
| CHEMBL2371961 | 216937 | 0 | None | - | 1 | Guinea pig | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@@H]1CN(C(=O)[C@H]2c3ccccc3CCN2C(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C2CCCCC21)C(=O)O | 10.1021/jm00035a015 | ||||
| 667 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00062a018 | ||||
| 6918173 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00062a018 | ||||
| 71364 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00062a018 | ||||
| CHEMBL2028850 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00062a018 | ||||
| DB06196 | 8754 | 37 | None | 1 | 6 | Guinea pig | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00062a018 | ||||
| 57402746 | 78348 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 734 | 11 | 1 | 7 | 4.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956721 | 78348 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 734 | 11 | 1 | 7 | 4.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963147 | 78348 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 734 | 11 | 1 | 7 | 4.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57402744 | 78356 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 762 | 12 | 5 | 9 | 2.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCNC(=N)N)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956718 | 78356 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 762 | 12 | 5 | 9 | 2.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCNC(=N)N)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963160 | 78356 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 762 | 12 | 5 | 9 | 2.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCNC(=N)N)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57400986 | 78357 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 762 | 13 | 1 | 7 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956723 | 78357 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 762 | 13 | 1 | 7 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963161 | 78357 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 762 | 13 | 1 | 7 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 16105690 | 90409 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 761 | 13 | 2 | 7 | 5.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@H](CCCN)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL220478 | 90409 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 761 | 13 | 2 | 7 | 5.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@H](CCCN)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10102701 | 144216 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 761 | 13 | 2 | 7 | 5.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCCN)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL375354 | 144216 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 761 | 13 | 2 | 7 | 5.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCCN)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 44337475 | 14854 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 329 | 5 | 0 | 4 | 1.4 | CC(=O)CN1CN(CCc2ccccc2)C2(CCN(C)CC2)C1=O | 10.1021/jm950676i | ||
| CHEMBL109123 | 14854 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 329 | 5 | 0 | 4 | 1.4 | CC(=O)CN1CN(CCc2ccccc2)C2(CCN(C)CC2)C1=O | 10.1021/jm950676i | ||
| 57401784 | 78414 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 734 | 13 | 2 | 7 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CNCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956875 | 78414 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 734 | 13 | 2 | 7 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CNCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963532 | 78414 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 734 | 13 | 2 | 7 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CNCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 16105751 | 90004 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 804 | 12 | 2 | 8 | 3.9 | CC(=O)N1CCC(NS(=O)(=O)c2ccc(Cl)c(COc3cccc4c(C)cc(C)nc34)c2Cl)(C(=O)N2CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC2)CC1 | 10.1021/jm061143k | ||
| CHEMBL218636 | 90004 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 804 | 12 | 2 | 8 | 3.9 | CC(=O)N1CCC(NS(=O)(=O)c2ccc(Cl)c(COc3cccc4c(C)cc(C)nc34)c2Cl)(C(=O)N2CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC2)CC1 | 10.1021/jm061143k | ||
| CHEMBL2369941 | 216516 | 0 | None | - | 1 | Guinea pig | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | CCCC1C[C@H](C(=O)N2C3CCCCC3C[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N(C(=O)[C@H](CO)NC(=O)[C@H](Cc2ccsc2)NC(=O)CNC(=O)[C@@H]2CC[C@H](O)N2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1 | 10.1021/jm00062a018 | ||||
| CHEMBL3038098 | 217710 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)CC1CCCCC1 | 10.1021/jm950716i | ||||
| CHEMBL5274928 | 200610 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 1290 | 30 | 18 | 17 | -4.8 | N=C(N)NCCCC(NC(=O)[C@@H]1C[C@@H]2CCC[C@@H]2N1C(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1cccs1)NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.6b01029 | ||
| 667 | 8754 | 37 | None | -1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm950716i | ||||
| 6918173 | 8754 | 37 | None | -1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm950716i | ||||
| 71364 | 8754 | 37 | None | -1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm950716i | ||||
| CHEMBL2028850 | 8754 | 37 | None | -1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm950716i | ||||
| DB06196 | 8754 | 37 | None | -1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm950716i | ||||
| 57394780 | 78417 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 776 | 14 | 1 | 7 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956852 | 78417 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 776 | 14 | 1 | 7 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963556 | 78417 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 776 | 14 | 1 | 7 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57392147 | 78444 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 720 | 12 | 2 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CNCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1955876 | 78444 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 720 | 12 | 2 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CNCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963660 | 78444 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 720 | 12 | 2 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CNCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 16105696 | 89983 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 790 | 13 | 1 | 6 | 5.6 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCC[N+](C)(C)C)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL218540 | 89983 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 790 | 13 | 1 | 6 | 5.6 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCC[N+](C)(C)C)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10441297 | 143666 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 804 | 14 | 1 | 6 | 6.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCC[N+](C)(C)C)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL374224 | 143666 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 804 | 14 | 1 | 6 | 6.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCC[N+](C)(C)C)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 11766718 | 143711 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 774 | 14 | 1 | 8 | 5.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCCN(C)C)N(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL374272 | 143711 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 774 | 14 | 1 | 8 | 5.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCCN(C)C)N(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 9897921 | 168680 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 761 | 13 | 2 | 7 | 5.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@@H](N)CCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL415151 | 168680 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 761 | 13 | 2 | 7 | 5.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@@H](N)CCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL3038106 | 217718 | 0 | None | 16 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H](O)C[C@@H]1C(=O)N1C[C@@H](O)C[C@@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C1CCCCC1 | 10.1021/jm950716i | ||||
| CHEMBL3038099 | 217711 | 0 | None | 2 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C1CCCCC1 | 10.1021/jm950716i | ||||
| 57399983 | 78350 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 777 | 13 | 2 | 8 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956859 | 78350 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 777 | 13 | 2 | 8 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963149 | 78350 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 777 | 13 | 2 | 8 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57396536 | 78359 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 707 | 10 | 1 | 6 | 4.6 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956860 | 78359 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 707 | 10 | 1 | 6 | 4.6 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963163 | 78359 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 707 | 10 | 1 | 6 | 4.6 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+](C)(CC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57396540 | 78365 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 705 | 7 | 1 | 6 | 4.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CC5)CC[N+](C)(C)CC6)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956867 | 78365 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 705 | 7 | 1 | 6 | 4.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CC5)CC[N+](C)(C)CC6)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963177 | 78365 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 705 | 7 | 1 | 6 | 4.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CC5)CC[N+](C)(C)CC6)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 16105698 | 143124 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 747 | 12 | 2 | 7 | 4.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCN)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL373459 | 143124 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 747 | 12 | 2 | 7 | 4.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@H](CCCN)[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 16105694 | 148672 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 732 | 12 | 1 | 6 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL386794 | 148672 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 732 | 12 | 1 | 6 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 22008895 | 117335 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 592 | 8 | 1 | 5 | 6.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(F)(F)F)cc4)c3C#N)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL325255 | 117335 | 0 | None | - | 1 | Guinea pig | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 592 | 8 | 1 | 5 | 6.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(F)(F)F)cc4)c3C#N)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| 10996140 | 74450 | 0 | None | 309 | 2 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 710 | 17 | 4 | 9 | 4.1 | CN(C)CCCN(C)CCCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(N/N=C(\S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL1907652 | 74450 | 0 | None | 309 | 2 | Rat | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 710 | 17 | 4 | 9 | 4.1 | CN(C)CCCN(C)CCCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(N/N=C(\S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 57393062 | 78352 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 706 | 11 | 1 | 7 | 4.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956869 | 78352 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 706 | 11 | 1 | 7 | 4.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963151 | 78352 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 706 | 11 | 1 | 7 | 4.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 16105727 | 90586 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 718 | 12 | 3 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL220591 | 90586 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 718 | 12 | 3 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 16105742 | 144932 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 733 | 11 | 2 | 7 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL376866 | 144932 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 733 | 11 | 2 | 7 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL5280457 | 200847 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 1312 | 30 | 18 | 17 | -4.6 | N=C(N)NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.6b01029 | ||
| CHEMBL3038094 | 217707 | 0 | None | 8 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C1CCCC1 | 10.1021/jm950716i | ||||
| CHEMBL3038095 | 217708 | 0 | None | 3 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)c1ccccc1 | 10.1021/jm950716i | ||||
| 57403505 | 78420 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 675 | 7 | 1 | 6 | 5.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CCCCC6)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956865 | 78420 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 675 | 7 | 1 | 6 | 5.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CCCCC6)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963559 | 78420 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 675 | 7 | 1 | 6 | 5.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CCCCC6)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57394784 | 78442 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 677 | 9 | 1 | 6 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(C[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956871 | 78442 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 677 | 9 | 1 | 6 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(C[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963658 | 78442 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 677 | 9 | 1 | 6 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(C[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 10463758 | 145649 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 692 | 12 | 2 | 8 | 3.8 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL378189 | 145649 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 692 | 12 | 2 | 8 | 3.8 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10101294 | 146932 | 0 | None | -5 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 706 | 12 | 2 | 8 | 4.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL380273 | 146932 | 0 | None | -5 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 706 | 12 | 2 | 8 | 4.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 44412007 | 83986 | 1 | None | -1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 710 | 12 | 4 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)N4CCC[C@@H]4C(=O)NCCCNC(=O)c4ccc(C(=N)N)cc4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL207939 | 83986 | 1 | None | -1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 710 | 12 | 4 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)N4CCC[C@@H]4C(=O)NCCCNC(=O)c4ccc(C(=N)N)cc4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10396101 | 91117 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 718 | 11 | 1 | 6 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL221683 | 91117 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 718 | 11 | 1 | 6 | 5.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10441167 | 103763 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 732 | 11 | 3 | 6 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=N)NCCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL266493 | 103763 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 732 | 11 | 3 | 6 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=N)NCCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10101294 | 146932 | 0 | None | -5 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 706 | 12 | 2 | 8 | 4.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL380273 | 146932 | 0 | None | -5 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 706 | 12 | 2 | 8 | 4.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10102296 | 168681 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 690 | 9 | 1 | 6 | 4.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL415152 | 168681 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 690 | 9 | 1 | 6 | 4.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 44316161 | 168295 | 0 | None | -1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 1043 | 25 | 12 | 16 | -4.0 | NCCCCC(N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)NC(Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O | 10.1021/jm990961s | ||
| CHEMBL412824 | 168295 | 0 | None | -1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 1043 | 25 | 12 | 16 | -4.0 | NCCCCC(N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)NC(Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O | 10.1021/jm990961s | ||
| 122189902 | 130201 | 0 | None | 13489 | 2 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 1304 | 30 | 18 | 17 | -4.4 | N=C(N)NCCC[C@H](NC(=O)C1CC2CCCCC2N1C(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](CO)NC(=O)C(Cc1cccs1)NC(=O)CNC(=O)C1CC(O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCNC(=N)N)C(=O)O | 10.1016/j.bmcl.2015.08.014 | ||
| CHEMBL3616944 | 130201 | 0 | None | 13489 | 2 | Guinea pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 1304 | 30 | 18 | 17 | -4.4 | N=C(N)NCCC[C@H](NC(=O)C1CC2CCCCC2N1C(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](CO)NC(=O)C(Cc1cccs1)NC(=O)CNC(=O)C1CC(O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCNC(=N)N)C(=O)O | 10.1016/j.bmcl.2015.08.014 | ||
| 3812 | 7504 | 42 | None | -1 | 6 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| 439201 | 7504 | 42 | None | -1 | 6 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| 649 | 7504 | 42 | None | -1 | 6 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| CHEMBL406291 | 7504 | 42 | None | -1 | 6 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| DB12126 | 7504 | 42 | None | -1 | 6 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| 5312119 | 7505 | 4 | None | 1148 | 2 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 682 | 15 | 4 | 9 | 2.9 | CN(CCN(C)C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])NNC(=S)NC(c1ccccc1)c1ccccc1 | 10.1021/jm991155o | ||
| 680 | 7505 | 4 | None | 1148 | 2 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 682 | 15 | 4 | 9 | 2.9 | CN(CCN(C)C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])NNC(=S)NC(c1ccccc1)c1ccccc1 | 10.1021/jm991155o | ||
| CHEMBL308468 | 7505 | 4 | None | 1148 | 2 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 682 | 15 | 4 | 9 | 2.9 | CN(CCN(C)C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])NNC(=S)NC(c1ccccc1)c1ccccc1 | 10.1021/jm991155o | ||
| 5312119 | 7505 | 4 | None | 1148 | 2 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 682 | 15 | 4 | 9 | 2.9 | CN(CCN(C)C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])NNC(=S)NC(c1ccccc1)c1ccccc1 | 10.1021/jm0111088 | ||
| 680 | 7505 | 4 | None | 1148 | 2 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 682 | 15 | 4 | 9 | 2.9 | CN(CCN(C)C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])NNC(=S)NC(c1ccccc1)c1ccccc1 | 10.1021/jm0111088 | ||
| CHEMBL308468 | 7505 | 4 | None | 1148 | 2 | Rat | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 682 | 15 | 4 | 9 | 2.9 | CN(CCN(C)C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])NNC(=S)NC(c1ccccc1)c1ccccc1 | 10.1021/jm0111088 | ||
| 57401782 | 78361 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 705 | 11 | 1 | 6 | 6.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956873 | 78361 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 705 | 11 | 1 | 6 | 6.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963165 | 78361 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 705 | 11 | 1 | 6 | 6.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 11600186 | 85072 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 734 | 14 | 2 | 8 | 4.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL210788 | 85072 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 734 | 14 | 2 | 8 | 4.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 16105701 | 90744 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 762 | 12 | 3 | 8 | 3.6 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCNCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL220693 | 90744 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 762 | 12 | 3 | 8 | 3.6 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCC[N+](C)(C)C)CC5)CCNCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10350966 | 91399 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 746 | 13 | 1 | 6 | 6.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL222167 | 91399 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 746 | 13 | 1 | 6 | 6.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL2370040 | 216552 | 0 | None | - | 1 | Guinea pig | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | C[C@@](Cc1ccccc1)(NC(=O)CNC(=O)[C@@H]1C[C@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm00069a016 | ||||
| 44337490 | 15940 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 307 | 3 | 0 | 4 | 1.5 | CC(=O)CN1CN(C2CCCCC2)C2(CCN(C)CC2)C1=O | 10.1021/jm950676i | ||
| CHEMBL110188 | 15940 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 307 | 3 | 0 | 4 | 1.5 | CC(=O)CN1CN(C2CCCCC2)C2(CCN(C)CC2)C1=O | 10.1021/jm950676i | ||
| 10556495 | 174718 | 0 | None | 2398 | 2 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 682 | 15 | 4 | 9 | 2.9 | CN(C)CCN(C)CCNC(=O)[C@H]1CCCN1S(=O)(=O)c1ccc(NNC(=S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm991155o | ||
| CHEMBL2112044 | 174718 | 0 | None | 2398 | 2 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 682 | 15 | 4 | 9 | 2.9 | CN(C)CCN(C)CCNC(=O)[C@H]1CCCN1S(=O)(=O)c1ccc(NNC(=S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm991155o | ||
| CHEMBL431562 | 174718 | 0 | None | 2398 | 2 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 682 | 15 | 4 | 9 | 2.9 | CN(C)CCN(C)CCNC(=O)[C@H]1CCCN1S(=O)(=O)c1ccc(NNC(=S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm991155o | ||
| 10556495 | 174718 | 0 | None | 2398 | 2 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 682 | 15 | 4 | 9 | 2.9 | CN(C)CCN(C)CCNC(=O)[C@H]1CCCN1S(=O)(=O)c1ccc(NNC(=S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL2112044 | 174718 | 0 | None | 2398 | 2 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 682 | 15 | 4 | 9 | 2.9 | CN(C)CCN(C)CCNC(=O)[C@H]1CCCN1S(=O)(=O)c1ccc(NNC(=S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL431562 | 174718 | 0 | None | 2398 | 2 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 682 | 15 | 4 | 9 | 2.9 | CN(C)CCN(C)CCNC(=O)[C@H]1CCCN1S(=O)(=O)c1ccc(NNC(=S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 44340859 | 16815 | 0 | None | - | 1 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 599 | 11 | 2 | 8 | 5.0 | COc1ccc(N(C)C(=O)CNC(=O)/C=C/c2ccc(NC(C)=O)nc2)c(SC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL115163 | 16815 | 0 | None | - | 1 | Guinea pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 599 | 11 | 2 | 8 | 5.0 | COc1ccc(N(C)C(=O)CNC(=O)/C=C/c2ccc(NC(C)=O)nc2)c(SC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| 57393060 | 78362 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 661 | 7 | 1 | 6 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CCCC6)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956851 | 78362 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 661 | 7 | 1 | 6 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CCCC6)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963174 | 78362 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 661 | 7 | 1 | 6 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CCCC6)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57398328 | 78443 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 719 | 12 | 1 | 6 | 6.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956874 | 78443 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 719 | 12 | 1 | 6 | 6.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963659 | 78443 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 719 | 12 | 1 | 6 | 6.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CCCC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 10439868 | 82701 | 0 | None | -12 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL205093 | 82701 | 0 | None | -12 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10463818 | 146050 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 720 | 14 | 2 | 8 | 4.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL379063 | 146050 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 720 | 14 | 2 | 8 | 4.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10010104 | 148052 | 0 | None | -7 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL383167 | 148052 | 0 | None | -7 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10439868 | 82701 | 0 | None | -12 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL205093 | 82701 | 0 | None | -12 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10463883 | 90608 | 0 | None | -25 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 746 | 13 | 2 | 8 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@@H](N)CCCN(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL220596 | 90608 | 0 | None | -25 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 746 | 13 | 2 | 8 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@@H](N)CCCN(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10079793 | 100895 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 717 | 11 | 3 | 7 | 4.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=N)NCCCN(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL249235 | 100895 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 717 | 11 | 3 | 7 | 4.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=N)NCCCN(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 16105729 | 143712 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 761 | 13 | 2 | 7 | 5.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL374273 | 143712 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 761 | 13 | 2 | 7 | 5.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCC[N+](C)(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10079797 | 144375 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 718 | 12 | 3 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@@H](N)CCCN)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL375576 | 144375 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 718 | 12 | 3 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@@H](N)CCCN)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10032895 | 144409 | 0 | None | -7 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 734 | 13 | 5 | 8 | 3.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCNC(=N)N)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL375820 | 144409 | 0 | None | -7 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 734 | 13 | 5 | 8 | 3.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCNC(=N)N)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10010104 | 148052 | 0 | None | -7 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL383167 | 148052 | 0 | None | -7 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 720 | 13 | 2 | 8 | 4.5 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 3812 | 7504 | 42 | None | 1 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| 439201 | 7504 | 42 | None | 1 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| 649 | 7504 | 42 | None | 1 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| CHEMBL406291 | 7504 | 42 | None | 1 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| DB12126 | 7504 | 42 | None | 1 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| 3812 | 7504 | 42 | None | 1 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm950716i | ||||
| 439201 | 7504 | 42 | None | 1 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm950716i | ||||
| 649 | 7504 | 42 | None | 1 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm950716i | ||||
| CHEMBL406291 | 7504 | 42 | None | 1 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm950716i | ||||
| DB12126 | 7504 | 42 | None | 1 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm950716i | ||||
| 71450888 | 85568 | 0 | None | 8 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1228 | 31 | 16 | 18 | -6.5 | NC(N)=NCCC[C@H](NC(=O)CN1C(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)CSc2ccccc21)C(=O)O | 10.1021/jm9901529 | ||
| CHEMBL2112698 | 85568 | 0 | None | 8 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1228 | 31 | 16 | 18 | -6.5 | NC(N)=NCCC[C@H](NC(=O)CN1C(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)CSc2ccccc21)C(=O)O | 10.1021/jm9901529 | ||
| CHEMBL5284501 | 201035 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1228 | 31 | 19 | 18 | -5.9 | N=C(N)NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C1=O | 10.1021/acs.jmedchem.6b01029 | ||
| 44355233 | 173435 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1228 | 31 | 16 | 18 | -6.5 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)NC1CSc2ccccc2N(CC(=O)N[C@H](CCCN=C(N)N)C(=O)O)C1=O | 10.1021/jm9901531 | ||
| CHEMBL428148 | 173435 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1228 | 31 | 16 | 18 | -6.5 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)NC1CSc2ccccc2N(CC(=O)N[C@H](CCCN=C(N)N)C(=O)O)C1=O | 10.1021/jm9901531 | ||
| 70683601 | 81293 | 0 | None | - | 1 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1270 | 33 | 15 | 15 | -4.3 | NC(N)=NCCC[C@H](NC(=O)[C@@H]1CC2CCCCC2N1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)O | 10.1021/jm00062a018 | ||
| CHEMBL2028979 | 81293 | 0 | None | - | 1 | Guinea pig | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1270 | 33 | 15 | 15 | -4.3 | NC(N)=NCCC[C@H](NC(=O)[C@@H]1CC2CCCCC2N1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)O | 10.1021/jm00062a018 | ||
| 667 | 8754 | 37 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01029 | ||||
| 6918173 | 8754 | 37 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01029 | ||||
| 71364 | 8754 | 37 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01029 | ||||
| CHEMBL2028850 | 8754 | 37 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01029 | ||||
| DB06196 | 8754 | 37 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | None | 10.1021/acs.jmedchem.6b01029 | ||||
| 9987299 | 85376 | 0 | None | 13 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 706 | 14 | 4 | 9 | 3.3 | CN(C)CCCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL2112283 | 85376 | 0 | None | 13 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 706 | 14 | 4 | 9 | 3.3 | CN(C)CCCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 57401780 | 78354 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 691 | 10 | 1 | 6 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956872 | 78354 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 691 | 10 | 1 | 6 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963153 | 78354 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 691 | 10 | 1 | 6 | 5.9 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCC(CC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 57391277 | 78441 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 692 | 10 | 1 | 7 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(CC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956868 | 78441 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 692 | 10 | 1 | 7 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(CC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963652 | 78441 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 692 | 10 | 1 | 7 | 4.4 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(CC[N+](C)(C)C)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 44412007 | 83986 | 1 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 710 | 12 | 4 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)N4CCC[C@@H]4C(=O)NCCCNC(=O)c4ccc(C(=N)N)cc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL207939 | 83986 | 1 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 710 | 12 | 4 | 7 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)N4CCC[C@@H]4C(=O)NCCCNC(=O)c4ccc(C(=N)N)cc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10102599 | 148182 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 706 | 13 | 2 | 8 | 4.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL383989 | 148182 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 706 | 13 | 2 | 8 | 4.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10418701 | 103877 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 760 | 13 | 5 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@@H](N)CCCNC(=N)N)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL267493 | 103877 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 760 | 13 | 5 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)C[C@@H](N)CCCNC(=N)N)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 122189902 | 130201 | 0 | None | 13489 | 2 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 1304 | 30 | 18 | 17 | -4.4 | N=C(N)NCCC[C@H](NC(=O)C1CC2CCCCC2N1C(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](CO)NC(=O)C(Cc1cccs1)NC(=O)CNC(=O)C1CC(O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCNC(=N)N)C(=O)O | 10.1016/j.bmcl.2015.08.014 | ||
| CHEMBL3616944 | 130201 | 0 | None | 13489 | 2 | Guinea pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 1304 | 30 | 18 | 17 | -4.4 | N=C(N)NCCC[C@H](NC(=O)C1CC2CCCCC2N1C(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](CO)NC(=O)C(Cc1cccs1)NC(=O)CNC(=O)C1CC(O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCNC(=N)N)C(=O)O | 10.1016/j.bmcl.2015.08.014 | ||
| 57401776 | 78351 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 690 | 7 | 1 | 7 | 4.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CCN(C)CC6)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1956866 | 78351 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 690 | 7 | 1 | 7 | 4.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CCN(C)CC6)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| CHEMBL1963150 | 78351 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 690 | 7 | 1 | 7 | 4.2 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CC[N+]6(CCN(C)CC6)CC5)CCOCC4)c3Cl)c2n1 | 10.1016/j.bmc.2012.01.036 | ||
| 10349694 | 83358 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 691 | 13 | 4 | 7 | 4.7 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=N)NCCCCCCN)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL206312 | 83358 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 691 | 13 | 4 | 7 | 4.7 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=N)NCCCCCCN)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10418252 | 145669 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 663 | 10 | 4 | 7 | 3.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=N)NCCCN)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL378237 | 145669 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 663 | 10 | 4 | 7 | 3.8 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=N)NCCCN)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10373970 | 144392 | 0 | None | -5 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 760 | 13 | 5 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCNC(=N)N)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL375689 | 144392 | 0 | None | -5 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 760 | 13 | 5 | 8 | 4.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCNC(=N)N)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 3812 | 7504 | 42 | None | 1 | 6 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2013.01.025 | ||||
| 439201 | 7504 | 42 | None | 1 | 6 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2013.01.025 | ||||
| 649 | 7504 | 42 | None | 1 | 6 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2013.01.025 | ||||
| CHEMBL406291 | 7504 | 42 | None | 1 | 6 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2013.01.025 | ||||
| DB12126 | 7504 | 42 | None | 1 | 6 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2013.01.025 | ||||
| 10055774 | 83478 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 734 | 14 | 4 | 8 | 3.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCCN=C(N)N)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL206474 | 83478 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 734 | 14 | 4 | 8 | 3.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)C[C@@H](N)CCCCN=C(N)N)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10441194 | 91397 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 745 | 13 | 4 | 7 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCCNC(=N)N)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL222156 | 91397 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 745 | 13 | 4 | 7 | 5.0 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)CCCCCNC(=N)N)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 44341039 | 16283 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 597 | 9 | 1 | 5 | 6.6 | COc1ccc(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)c(Cl)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL112140 | 16283 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 597 | 9 | 1 | 5 | 6.6 | COc1ccc(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)c(Cl)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| 18941145 | 16735 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 569 | 9 | 1 | 6 | 6.3 | COc1cccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4sc(C)nc34)c2Cl)c1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL114732 | 16735 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 569 | 9 | 1 | 6 | 6.3 | COc1cccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4sc(C)nc34)c2Cl)c1 | 10.1016/s0960-894x(98)00736-7 | ||
| 22008892 | 116939 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 561 | 8 | 1 | 4 | 6.6 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(F)(F)F)cc4)c3C)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL323693 | 116939 | 0 | None | - | 1 | Guinea pig | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 561 | 8 | 1 | 4 | 6.6 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(F)(F)F)cc4)c3C)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| 11136263 | 85361 | 0 | None | 43 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 704 | 13 | 4 | 10 | 3.9 | CN(C)CCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(N/N=C(\S)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL2112221 | 85361 | 0 | None | 43 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 704 | 13 | 4 | 10 | 3.9 | CN(C)CCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(N/N=C(\S)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL2370010 | 216546 | 0 | None | - | 1 | Guinea pig | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@@H]1C2CCCCC2CN1C(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](CO)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N2CCC[C@H]2C(=O)NCC(=O)N1)C(=O)O | 10.1021/jm00069a016 | ||||
| 10418495 | 84650 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 649 | 10 | 4 | 7 | 3.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=N)NCCCN)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL209346 | 84650 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 649 | 10 | 4 | 7 | 3.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=N)NCCCN)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10260476 | 84772 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 691 | 14 | 3 | 7 | 4.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(CCCCCCN=C(N)N)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL209719 | 84772 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 691 | 14 | 3 | 7 | 4.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(CCCCCCN=C(N)N)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 9988753 | 90607 | 0 | None | -7 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 746 | 13 | 2 | 8 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| CHEMBL220595 | 90607 | 0 | None | -7 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 746 | 13 | 2 | 8 | 5.1 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC4(C(=O)N5CCN(C(=O)[C@@H](N)CCCCN(C)C)CC5)CCCC4)c3Cl)c2n1 | 10.1021/jm061143k | ||
| 10788314 | 126745 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 421 | 7 | 4 | 5 | 3.7 | NC(=O)c1ccc(N/N=C(/S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm991155o | ||
| CHEMBL349817 | 126745 | 0 | None | - | 1 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 421 | 7 | 4 | 5 | 3.7 | NC(=O)c1ccc(N/N=C(/S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm991155o | ||
| 18941160 | 16687 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 553 | 8 | 1 | 5 | 6.6 | Cc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4sc(C)nc34)c2Cl)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL114401 | 16687 | 0 | None | - | 1 | Guinea pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 553 | 8 | 1 | 5 | 6.6 | Cc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4sc(C)nc34)c2Cl)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| 10010669 | 83586 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 706 | 13 | 2 | 8 | 4.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL206938 | 83586 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 706 | 13 | 2 | 8 | 4.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)[C@@H](N)CCCCN(C)C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 44276460 | 106015 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 610 | 9 | 0 | 6 | 7.6 | CCn1c(CC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)ccc1C(=O)c1ccc(C#N)cc1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL281706 | 106015 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 610 | 9 | 0 | 6 | 7.6 | CCn1c(CC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)ccc1C(=O)c1ccc(C#N)cc1 | 10.1016/s0960-894x(03)00104-5 | ||
| 11527838 | 85133 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 635 | 10 | 3 | 7 | 2.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(CCN=C(N)N)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL211017 | 85133 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 635 | 10 | 3 | 7 | 2.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(CCN=C(N)N)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11513471 | 145425 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 748 | 14 | 2 | 8 | 4.4 | CC(=O)N[C@@H](CCCCN(C)C)C(=O)N1CCN(C(=O)C(C)(C)NS(=O)(=O)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)CC1 | 10.1021/jm060137l | ||
| CHEMBL377612 | 145425 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 748 | 14 | 2 | 8 | 4.4 | CC(=O)N[C@@H](CCCCN(C)C)C(=O)N1CCN(C(=O)C(C)(C)NS(=O)(=O)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)CC1 | 10.1021/jm060137l | ||
| 9987299 | 85376 | 0 | None | -13 | 2 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 706 | 14 | 4 | 9 | 3.3 | CN(C)CCCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL2112283 | 85376 | 0 | None | -13 | 2 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 706 | 14 | 4 | 9 | 3.3 | CN(C)CCCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 44410425 | 103914 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 1332 | 32 | 16 | 17 | -4.3 | NC(N)=NCCC[C@H](NC(=O)[C@@H]1CC2(CCCC2)C2CCC[C@](Cc3ccccc3)(NC(=O)[C@H](CO)NC(=O)[C@H](Cc3cccs3)NC(=O)CNC(=O)[C@@H]3CC(O)CN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N21)C(=O)O | 10.1016/j.bmcl.2006.01.125 | ||
| CHEMBL267822 | 103914 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 1332 | 32 | 16 | 17 | -4.3 | NC(N)=NCCC[C@H](NC(=O)[C@@H]1CC2(CCCC2)C2CCC[C@](Cc3ccccc3)(NC(=O)[C@H](CO)NC(=O)[C@H](Cc3cccs3)NC(=O)CNC(=O)[C@@H]3CC(O)CN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N21)C(=O)O | 10.1016/j.bmcl.2006.01.125 | ||
| 11699718 | 83862 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 524 | 9 | 3 | 6 | 3.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCN)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL207465 | 83862 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 524 | 9 | 3 | 6 | 3.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCN)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11513163 | 84551 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 578 | 7 | 2 | 6 | 4.7 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCCNCCC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL209130 | 84551 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 578 | 7 | 2 | 6 | 4.7 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCCNCCC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 44320402 | 21120 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 713 | 18 | 3 | 2 | 11.2 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2cccc3ccccc23)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1021/jm00069a021 | ||
| CHEMBL1162589 | 21120 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 713 | 18 | 3 | 2 | 11.2 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2cccc3ccccc23)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1021/jm00069a021 | ||
| CHEMBL1200092 | 21120 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 713 | 18 | 3 | 2 | 11.2 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2cccc3ccccc23)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1021/jm00069a021 | ||
| 44347466 | 21108 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 836 | 20 | 3 | 3 | 11.4 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)C2Cc3ccccc3CN2C(=O)[C@H](CCc2ccccc2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00037-T | ||
| CHEMBL1162799 | 21108 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 836 | 20 | 3 | 3 | 11.4 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)C2Cc3ccccc3CN2C(=O)[C@H](CCc2ccccc2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00037-T | ||
| CHEMBL1200034 | 21108 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 836 | 20 | 3 | 3 | 11.4 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)C2Cc3ccccc3CN2C(=O)[C@H](CCc2ccccc2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00037-T | ||
| 44347552 | 18950 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 613 | 17 | 1 | 2 | 9.5 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)C2Cc3ccccc3CN2C(=O)CCCc2ccccc2)cc1 | 10.1016/0960-894X(95)00037-T | ||
| CHEMBL1184218 | 18950 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 613 | 17 | 1 | 2 | 9.5 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)C2Cc3ccccc3CN2C(=O)CCCc2ccccc2)cc1 | 10.1016/0960-894X(95)00037-T | ||
| CHEMBL339723 | 18950 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 613 | 17 | 1 | 2 | 9.5 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)C2Cc3ccccc3CN2C(=O)CCCc2ccccc2)cc1 | 10.1016/0960-894X(95)00037-T | ||
| 2324360 | 63967 | 12 | None | - | 1 | Rat | 4.0 | pKi | = | 4 | Binding | ChEMBL | 257 | 4 | 3 | 2 | 2.7 | S=C(NCc1ccccc1)NNc1ccccc1 | 10.1021/jm991155o | ||
| CHEMBL164968 | 63967 | 12 | None | - | 1 | Rat | 4.0 | pKi | = | 4 | Binding | ChEMBL | 257 | 4 | 3 | 2 | 2.7 | S=C(NCc1ccccc1)NNc1ccccc1 | 10.1021/jm991155o | ||
| 44215785 | 102309 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 557 | 8 | 0 | 7 | 5.8 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(C#N)nc5)n4C)c3C)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL25751 | 102309 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 557 | 8 | 0 | 7 | 5.8 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(C#N)nc5)n4C)c3C)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 101653258 | 20554 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 712 | 18 | 3 | 2 | 11.5 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2cccc3ccccc23)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 44320402 | 20554 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 712 | 18 | 3 | 2 | 11.5 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2cccc3ccccc23)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1195447 | 20554 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 712 | 18 | 3 | 2 | 11.5 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2cccc3ccccc23)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL554592 | 20554 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 712 | 18 | 3 | 2 | 11.5 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2cccc3ccccc23)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 44355241 | 175503 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 1134 | 31 | 16 | 17 | -8.4 | NC(N)=NCCC[C@H](NC(=O)CN1CC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1=O)C(=O)O | 10.1021/jm9901531 | ||
| CHEMBL436963 | 175503 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 1134 | 31 | 16 | 17 | -8.4 | NC(N)=NCCC[C@H](NC(=O)CN1CC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1=O)C(=O)O | 10.1021/jm9901531 | ||
| 118719116 | 122222 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 1285 | 32 | 16 | 18 | -5.8 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@H](CCCN=C(N)N)C(=O)O)C1=O | 10.1021/jm9901531 | ||
| CHEMBL3350763 | 122222 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 1285 | 32 | 16 | 18 | -5.8 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@H](CCCN=C(N)N)C(=O)O)C1=O | 10.1021/jm9901531 | ||
| 44346315 | 20613 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 771 | 12 | 3 | 2 | 10.1 | O=C(Nc1ccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1195864 | 20613 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 771 | 12 | 3 | 2 | 10.1 | O=C(Nc1ccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL555493 | 20613 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 771 | 12 | 3 | 2 | 10.1 | O=C(Nc1ccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| 44346282 | 19120 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 712 | 30 | 1 | 1 | 15.1 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(NC(=O)c2ccc(C[P+](CCCCC)(CCCCC)CCCCC)cc2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1185367 | 19120 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 712 | 30 | 1 | 1 | 15.1 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(NC(=O)c2ccc(C[P+](CCCCC)(CCCCC)CCCCC)cc2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL409910 | 19120 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 712 | 30 | 1 | 1 | 15.1 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(NC(=O)c2ccc(C[P+](CCCCC)(CCCCC)CCCCC)cc2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 9919335 | 113362 | 1 | None | -489 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 922 | 22 | 9 | 13 | -2.1 | NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC2(CC1)C(=O)N(CC(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc3ccccc3N(CC(=O)O)C1=O)CN2CCc1ccccc1 | 10.1021/jm990962k | ||
| CHEMBL3142392 | 113362 | 1 | None | -489 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 922 | 22 | 9 | 13 | -2.1 | NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC2(CC1)C(=O)N(CC(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc3ccccc3N(CC(=O)O)C1=O)CN2CCc1ccccc1 | 10.1021/jm990962k | ||
| 11050762 | 74449 | 0 | None | -5248 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 696 | 16 | 4 | 9 | 3.7 | CN(C)CCCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(N/N=C(\S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL1907651 | 74449 | 0 | None | -5248 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 696 | 16 | 4 | 9 | 3.7 | CN(C)CCCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(N/N=C(\S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 71456185 | 85304 | 0 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 473 | 6 | 3 | 3 | 5.0 | N=C(N)Nc1cccc(CN2C(=O)[C@@H](Cc3ccccc3)N=C(c3ccccc3)c3ccccc32)c1 | 10.1016/s0960-894x(99)00015-3 | ||
| CHEMBL2111994 | 85304 | 0 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 473 | 6 | 3 | 3 | 5.0 | N=C(N)Nc1cccc(CN2C(=O)[C@@H](Cc3ccccc3)N=C(c3ccccc3)c3ccccc32)c1 | 10.1016/s0960-894x(99)00015-3 | ||
| CHEMBL3038100 | 217712 | 0 | None | -14 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | None | None | None | N=C(N)NCCCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N1C[C@@H](O)C[C@@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C1CCCCC1 | 10.1021/jm950716i | ||||
| CHEMBL2372276 | 216985 | 0 | None | 3 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)[C@@H]1CCCN1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CCCN=C(N)N)C(=O)O | 10.1021/jm950716i | ||||
| 1016 | 10519 | 78 | None | -46 | 35 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
| 2561 | 10519 | 78 | None | -46 | 35 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
| 2733526 | 10519 | 78 | None | -46 | 35 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
| 5384 | 10519 | 78 | None | -46 | 35 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
| CHEMBL83 | 10519 | 78 | None | -46 | 35 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
| DB00675 | 10519 | 78 | None | -46 | 35 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | nan | ||
| 22288574 | 106354 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 606 | 8 | 0 | 6 | 7.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(Cl)nc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL283824 | 106354 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 606 | 8 | 0 | 6 | 7.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(Cl)nc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 11549560 | 85046 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 671 | 14 | 4 | 7 | 4.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4ccc(C(N)=O)cc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL210708 | 85046 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 671 | 14 | 4 | 7 | 4.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4ccc(C(N)=O)cc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL5268614 | 200354 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 1024 | 24 | 13 | 13 | -3.9 | N=C(N)NCCCC(NC(=O)CN1CCCCC2(CCCN2C(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCNC(=N)N)C1=O)C(=O)O | 10.1021/acs.jmedchem.6b01029 | ||
| 44276438 | 106221 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 580 | 9 | 0 | 6 | 7.0 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CCc4ccc(C(=O)c5ccc(Cl)nc5)n4C)c3C)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL282981 | 106221 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 580 | 9 | 0 | 6 | 7.0 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CCc4ccc(C(=O)c5ccc(Cl)nc5)n4C)c3C)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 44355038 | 168473 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1065 | 25 | 13 | 15 | -5.1 | NC(N)=NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)NC1CSc2ccccc2N(CC(=O)N[C@H](CCCN=C(N)N)C(=O)O)C1=O | 10.1021/jm9901529 | ||
| CHEMBL413386 | 168473 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1065 | 25 | 13 | 15 | -5.1 | NC(N)=NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)NC1CSc2ccccc2N(CC(=O)N[C@H](CCCN=C(N)N)C(=O)O)C1=O | 10.1021/jm9901529 | ||
| CHEMBL5279008 | 200789 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1049 | 25 | 14 | 14 | -3.7 | N=C(N)NCCC[C@H](NC(=O)CN1C(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCNC(=N)N)CSc2ccccc21)C(=O)O | 10.1021/acs.jmedchem.6b01029 | ||
| 70695304 | 84225 | 0 | None | 17 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 556 | 8 | 2 | 6 | 4.0 | Cc1ccc2cccc(OCc3cc(S(=O)(=O)N4CCC[C@H]4C(=O)NCC4CCNCC4)ccc3Cl)c2n1 | 10.1021/jm2016057 | ||
| CHEMBL2087027 | 84225 | 0 | None | 17 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 556 | 8 | 2 | 6 | 4.0 | Cc1ccc2cccc(OCc3cc(S(=O)(=O)N4CCC[C@H]4C(=O)NCC4CCNCC4)ccc3Cl)c2n1 | 10.1021/jm2016057 | ||
| 44346367 | 17023 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 547 | 7 | 3 | 3 | 7.1 | O=C(Nc1cnc2ccccc2c1)[C@@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1160972 | 17023 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 547 | 7 | 3 | 3 | 7.1 | O=C(Nc1cnc2ccccc2c1)[C@@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| 18941161 | 16501 | 0 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 615 | 9 | 1 | 5 | 8.0 | Cc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4sc(-c5ccccc5)nc34)c2Cl)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113320 | 16501 | 0 | None | - | 1 | Guinea pig | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 615 | 9 | 1 | 5 | 8.0 | Cc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4sc(-c5ccccc5)nc34)c2Cl)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| 11342079 | 168565 | 0 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 567 | 9 | 2 | 4 | 6.0 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL414091 | 168565 | 0 | None | - | 1 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 567 | 9 | 2 | 4 | 6.0 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| 44355196 | 148302 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1328 | 35 | 16 | 18 | -6.0 | NC(N)=NCCC[C@H](NC(=O)CN1C(=O)[C@](Cc2ccccc2)(NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)C1Cc1ccccc1)C(=O)O | 10.1021/jm9901531 | ||
| CHEMBL384617 | 148302 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1328 | 35 | 16 | 18 | -6.0 | NC(N)=NCCC[C@H](NC(=O)CN1C(=O)[C@](Cc2ccccc2)(NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)C1Cc1ccccc1)C(=O)O | 10.1021/jm9901531 | ||
| CHEMBL3038101 | 217713 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)c1ccccc1 | 10.1021/jm950716i | ||||
| 57393602 | 74454 | 0 | None | -3 | 2 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 708 | 13 | 4 | 9 | 3.0 | CN(C)CCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=S)NC2Cc3ccccc3Cc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL1907656 | 74454 | 0 | None | -3 | 2 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 708 | 13 | 4 | 9 | 3.0 | CN(C)CCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=S)NC2Cc3ccccc3Cc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL2370011 | 216547 | 0 | None | - | 1 | Guinea pig | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@@H]1C2CCCCC2CN1C(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)O | 10.1021/jm00069a016 | ||||
| 44346372 | 19876 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 727 | 18 | 3 | 2 | 12.3 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N/C(=N/c2ccc(C)cc2)Nc2ccc(C)cc2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1190356 | 19876 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 727 | 18 | 3 | 2 | 12.3 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N/C(=N/c2ccc(C)cc2)Nc2ccc(C)cc2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL540643 | 19876 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 727 | 18 | 3 | 2 | 12.3 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@@H](Cc2ccc3ccccc3c2)N/C(=N/c2ccc(C)cc2)Nc2ccc(C)cc2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 71456177 | 85281 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1222 | 30 | 16 | 17 | -6.7 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@@H]1CCc2cccc3c2N(C1=O)[C@@H](C(=O)N[C@H](CCCN=C(N)N)C(=O)O)C3 | 10.1021/jm9901531 | ||
| CHEMBL2111891 | 85281 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1222 | 30 | 16 | 17 | -6.7 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@@H]1CCc2cccc3c2N(C1=O)[C@@H](C(=O)N[C@H](CCCN=C(N)N)C(=O)O)C3 | 10.1021/jm9901531 | ||
| 11284303 | 73116 | 0 | None | 2 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 553 | 15 | 1 | 7 | 4.7 | CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm049747g | ||
| CHEMBL185068 | 73116 | 0 | None | 2 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 553 | 15 | 1 | 7 | 4.7 | CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm049747g | ||
| 44276461 | 105049 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 551 | 9 | 0 | 6 | 7.0 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CCc4ccc(C(=O)c5cccs5)n4C)c3C)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL27461 | 105049 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 551 | 9 | 0 | 6 | 7.0 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CCc4ccc(C(=O)c5cccs5)n4C)c3C)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 10556495 | 174718 | 0 | None | -2398 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 682 | 15 | 4 | 9 | 2.9 | CN(C)CCN(C)CCNC(=O)[C@H]1CCCN1S(=O)(=O)c1ccc(NNC(=S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL2112044 | 174718 | 0 | None | -2398 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 682 | 15 | 4 | 9 | 2.9 | CN(C)CCN(C)CCNC(=O)[C@H]1CCCN1S(=O)(=O)c1ccc(NNC(=S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL431562 | 174718 | 0 | None | -2398 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 682 | 15 | 4 | 9 | 2.9 | CN(C)CCN(C)CCNC(=O)[C@H]1CCCN1S(=O)(=O)c1ccc(NNC(=S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 10770256 | 63939 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 627 | 16 | 3 | 8 | 4.5 | CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(N/N=C(/S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm991155o | ||
| CHEMBL164754 | 63939 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 627 | 16 | 3 | 8 | 4.5 | CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(N/N=C(/S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm991155o | ||
| 44276793 | 106298 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 586 | 9 | 0 | 6 | 7.0 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CCc4ccc(C(=O)c5cccnc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL283394 | 106298 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 586 | 9 | 0 | 6 | 7.0 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CCc4ccc(C(=O)c5cccnc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 11467345 | 168730 | 0 | None | -489 | 2 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 581 | 9 | 2 | 4 | 6.4 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL415629 | 168730 | 0 | None | -489 | 2 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 581 | 9 | 2 | 4 | 6.4 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| 11549562 | 84287 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 671 | 14 | 3 | 7 | 5.8 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4ccc(N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL208738 | 84287 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 671 | 14 | 3 | 7 | 5.8 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4ccc(N(C)C)cc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11549335 | 146927 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 578 | 9 | 3 | 6 | 4.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCC4CCNCC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL380260 | 146927 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 578 | 9 | 3 | 6 | 4.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCC4CCNCC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11621618 | 146935 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 538 | 10 | 3 | 6 | 4.0 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCN)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL380282 | 146935 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 538 | 10 | 3 | 6 | 4.0 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCN)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11621850 | 173097 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 618 | 13 | 4 | 7 | 4.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4c[nH]cn4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL427217 | 173097 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 618 | 13 | 4 | 7 | 4.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4c[nH]cn4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 51351563 | 65282 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 473 | 6 | 3 | 3 | 5.0 | N=C(N)Nc1cccc(CN2C(=O)[C@H](Cc3ccccc3)N=C(c3ccccc3)c3ccccc32)c1 | 10.1016/s0960-894x(99)00015-3 | ||
| CHEMBL1683738 | 65282 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 473 | 6 | 3 | 3 | 5.0 | N=C(N)Nc1cccc(CN2C(=O)[C@H](Cc3ccccc3)N=C(c3ccccc3)c3ccccc32)c1 | 10.1016/s0960-894x(99)00015-3 | ||
| 71450890 | 85570 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 1222 | 30 | 16 | 17 | -6.7 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@H]1CCc2cccc3c2N(C1=O)[C@@H](C(=O)N[C@H](CCCN=C(N)N)C(=O)O)C3 | 10.1021/jm9901531 | ||
| CHEMBL2112709 | 85570 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 1222 | 30 | 16 | 17 | -6.7 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@H]1CCc2cccc3c2N(C1=O)[C@@H](C(=O)N[C@H](CCCN=C(N)N)C(=O)O)C3 | 10.1021/jm9901531 | ||
| 44340818 | 117386 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 539 | 8 | 1 | 5 | 6.3 | Cc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4scnc34)c2Cl)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL325624 | 117386 | 0 | None | - | 1 | Guinea pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 539 | 8 | 1 | 5 | 6.3 | Cc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4scnc34)c2Cl)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| 10662116 | 63323 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 302 | 5 | 3 | 4 | 3.0 | O=[N+]([O-])c1ccccc1N/N=C(/S)NCc1ccccc1 | 10.1021/jm991155o | ||
| CHEMBL163956 | 63323 | 0 | None | - | 1 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 302 | 5 | 3 | 4 | 3.0 | O=[N+]([O-])c1ccccc1N/N=C(/S)NCc1ccccc1 | 10.1021/jm991155o | ||
| 16108965 | 168109 | 0 | None | -1000 | 2 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 646 | 9 | 2 | 6 | 4.9 | CN1c2cc(CN3CCCCC3)ccc2[C@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O | 10.1021/jm061224g | ||
| CHEMBL412552 | 168109 | 0 | None | -1000 | 2 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 646 | 9 | 2 | 6 | 4.9 | CN1c2cc(CN3CCCCC3)ccc2[C@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O | 10.1021/jm061224g | ||
| 71459890 | 85280 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 1228 | 31 | 16 | 18 | -6.5 | NC(N)=NCCC[C@H](NC(=O)CN1C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)CSc2ccccc21)C(=O)O | 10.1021/jm9901529 | ||
| CHEMBL2111889 | 85280 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 1228 | 31 | 16 | 18 | -6.5 | NC(N)=NCCC[C@H](NC(=O)CN1C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)CSc2ccccc21)C(=O)O | 10.1021/jm9901529 | ||
| CHEMBL2370038 | 216551 | 0 | None | - | 1 | Guinea pig | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | None | None | None | CN(CC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(=O)[C@@H]1C[C@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N | 10.1021/jm00069a016 | ||||
| 44276753 | 172106 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 551 | 7 | 0 | 5 | 7.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)C(C)(C)C)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL423482 | 172106 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 551 | 7 | 0 | 5 | 7.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)C(C)(C)C)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 10327403 | 85360 | 0 | None | -63 | 2 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 702 | 14 | 4 | 10 | 3.8 | CN(C)CCCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL2112220 | 85360 | 0 | None | -63 | 2 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 702 | 14 | 4 | 10 | 3.8 | CN(C)CCCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 44276287 | 171598 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 577 | 8 | 0 | 5 | 7.7 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)C5CCCCC5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL421863 | 171598 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 577 | 8 | 0 | 5 | 7.7 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)C5CCCCC5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 44346451 | 17026 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 695 | 10 | 3 | 3 | 8.4 | O=C(NC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1160979 | 17026 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 695 | 10 | 3 | 3 | 8.4 | O=C(NC1C2CCN(CC2)C1C(c1ccccc1)c1ccccc1)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| 44355256 | 164002 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 1148 | 31 | 16 | 17 | -8.0 | NC(N)=NCCC[C@H](NC(=O)CN1CCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1=O)C(=O)O | 10.1021/jm9901531 | ||
| CHEMBL407626 | 164002 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 1148 | 31 | 16 | 17 | -8.0 | NC(N)=NCCC[C@H](NC(=O)CN1CCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1=O)C(=O)O | 10.1021/jm9901531 | ||
| 672 | 9047 | 21 | None | -1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| 6918284 | 9047 | 21 | None | -1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| CHEMBL2105864 | 9047 | 21 | None | -1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| DB06549 | 9047 | 21 | None | -1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9901529 | ||||
| 44276550 | 104073 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 570 | 9 | 0 | 6 | 6.8 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CCc4ccc(C(=O)c5ccc(C#N)cc5)n4C)c3C)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL26908 | 104073 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 570 | 9 | 0 | 6 | 6.8 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CCc4ccc(C(=O)c5ccc(C#N)cc5)n4C)c3C)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL2370748 | 216697 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | None | None | None | Cc1ccc(C[C@@H](CN[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCN=C(N)N)cc1 | 10.1021/jm9901531 | ||||
| 11577748 | 84872 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 566 | 10 | 4 | 6 | 2.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCN=C(N)N)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL210217 | 84872 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 566 | 10 | 4 | 6 | 2.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCN=C(N)N)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11505970 | 84956 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 656 | 13 | 5 | 7 | 5.4 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNc4ccc(C(=N)N)cc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL210472 | 84956 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 656 | 13 | 5 | 7 | 5.4 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNc4ccc(C(=N)N)cc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL5272490 | 200505 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1210 | 31 | 19 | 17 | -6.4 | N=C(N)NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C1=O | 10.1021/acs.jmedchem.6b01029 | ||
| 11585604 | 83902 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 566 | 11 | 2 | 6 | 4.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCN(C)C)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL207692 | 83902 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 566 | 11 | 2 | 6 | 4.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCN(C)C)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11672243 | 84973 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 658 | 14 | 3 | 7 | 5.8 | COc1ccc(CNCCCNC(=O)C(C)(C)NS(=O)(=O)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm060137l | ||
| CHEMBL210524 | 84973 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 658 | 14 | 3 | 7 | 5.8 | COc1ccc(CNCCCNC(=O)C(C)(C)NS(=O)(=O)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm060137l | ||
| 11600235 | 145189 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 642 | 13 | 3 | 6 | 6.1 | Cc1ccc(CNCCCNC(=O)C(C)(C)NS(=O)(=O)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm060137l | ||
| CHEMBL377370 | 145189 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 642 | 13 | 3 | 6 | 6.1 | Cc1ccc(CNCCCNC(=O)C(C)(C)NS(=O)(=O)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | 10.1021/jm060137l | ||
| 11707335 | 146097 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 552 | 11 | 3 | 6 | 4.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCCN)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL379259 | 146097 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 552 | 11 | 3 | 6 | 4.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCCN)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11672186 | 146473 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 628 | 13 | 3 | 6 | 5.8 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4ccccc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL379806 | 146473 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 628 | 13 | 3 | 6 | 5.8 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4ccccc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL5266765 | 200270 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1212 | 31 | 19 | 18 | -6.6 | N=C(N)NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@@H]1COc2ccccc2N(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C1=O | 10.1021/acs.jmedchem.6b01029 | ||
| 44355427 | 148655 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1212 | 31 | 16 | 18 | -7.2 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)NC1COc2ccccc2N(CC(=O)N[C@H](CCCN=C(N)N)C(=O)O)C1=O | 10.1021/jm9901531 | ||
| CHEMBL386697 | 148655 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1212 | 31 | 16 | 18 | -7.2 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)NC1COc2ccccc2N(CC(=O)N[C@H](CCCN=C(N)N)C(=O)O)C1=O | 10.1021/jm9901531 | ||
| 22008929 | 16522 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 597 | 9 | 1 | 5 | 6.6 | COc1c(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)ccc(Cl)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113465 | 16522 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 597 | 9 | 1 | 5 | 6.6 | COc1c(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)ccc(Cl)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| 10056816 | 84524 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 649 | 13 | 2 | 7 | 5.1 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(CCCCCCN)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL209038 | 84524 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 649 | 13 | 2 | 7 | 5.1 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(CCCCCCN)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL3038096 | 217709 | 0 | None | 6 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc1ccccc1)C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C1CCCCC1 | 10.1021/jm950716i | ||||
| 10327403 | 85360 | 0 | None | 63 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 702 | 14 | 4 | 10 | 3.8 | CN(C)CCCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL2112220 | 85360 | 0 | None | 63 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 702 | 14 | 4 | 10 | 3.8 | CN(C)CCCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 9851817 | 16453 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 607 | 8 | 1 | 5 | 7.3 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(F)(F)F)cc4)c3Cl)cccc2s1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL112991 | 16453 | 0 | None | - | 1 | Guinea pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 607 | 8 | 1 | 5 | 7.3 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(F)(F)F)cc4)c3Cl)cccc2s1 | 10.1016/s0960-894x(98)00736-7 | ||
| 44340760 | 117285 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 523 | 10 | 3 | 6 | 3.8 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCCCC(=O)O)c3C#N)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL324950 | 117285 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 523 | 10 | 3 | 6 | 3.8 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)NCCCC(=O)O)c3C#N)c2n1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL2372276 | 216985 | 0 | None | 3 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)[C@@H]1CCCN1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CCCN=C(N)N)C(=O)O | 10.1021/jm8007618 | ||||
| 22288598 | 103942 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 642 | 9 | 0 | 6 | 6.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(C(=O)N(C)C)cc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL26810 | 103942 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 642 | 9 | 0 | 6 | 6.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(C(=O)N(C)C)cc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 44355288 | 103549 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1224 | 33 | 16 | 17 | -6.8 | NC(N)=NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)N1CC[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1=O)C(=O)O | 10.1021/jm9901531 | ||
| CHEMBL264712 | 103549 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1224 | 33 | 16 | 17 | -6.8 | NC(N)=NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)N1CC[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1=O)C(=O)O | 10.1021/jm9901531 | ||
| 44346465 | 18205 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 584 | 23 | 0 | 0 | 13.2 | CCCC[P+](CCCC)(CCCC)Cc1ccc(-c2ccc(C[P+](CCCC)(CCCC)CCCC)cc2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1180311 | 18205 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 584 | 23 | 0 | 0 | 13.2 | CCCC[P+](CCCC)(CCCC)Cc1ccc(-c2ccc(C[P+](CCCC)(CCCC)CCCC)cc2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL121350 | 18205 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 584 | 23 | 0 | 0 | 13.2 | CCCC[P+](CCCC)(CCCC)Cc1ccc(-c2ccc(C[P+](CCCC)(CCCC)CCCC)cc2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 44346306 | 17019 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 529 | 7 | 3 | 3 | 5.2 | O=C(NC1CN2CCC1CC2)C(Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1160968 | 17019 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 529 | 7 | 3 | 3 | 5.2 | O=C(NC1CN2CCC1CC2)C(Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| 44320168 | 17020 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 529 | 7 | 3 | 3 | 5.2 | O=C(NC1CN2CCC1CC2)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1021/jm00069a021 | ||
| CHEMBL1160969 | 17020 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 529 | 7 | 3 | 3 | 5.2 | O=C(NC1CN2CCC1CC2)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1021/jm00069a021 | ||
| CHEMBL444322 | 17020 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 529 | 7 | 3 | 3 | 5.2 | O=C(NC1CN2CCC1CC2)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1021/jm00069a021 | ||
| 9826248 | 40856 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 439 | 8 | 3 | 3 | 3.7 | N=C(N)NCCCCN1C(=O)C(Cc2ccccc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/s0960-894x(99)00015-3 | ||
| CHEMBL142515 | 40856 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 439 | 8 | 3 | 3 | 3.7 | N=C(N)NCCCCN1C(=O)C(Cc2ccccc2)N=C(c2ccccc2)c2ccccc21 | 10.1016/s0960-894x(99)00015-3 | ||
| CHEMBL3038103 | 217715 | 0 | None | 61 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C1CCCCC1)C1CCCC1 | 10.1021/jm950716i | ||||
| 44276711 | 103706 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 571 | 8 | 0 | 5 | 7.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccccc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL26604 | 103706 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 571 | 8 | 0 | 5 | 7.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccccc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 15952860 | 106024 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 596 | 8 | 0 | 6 | 7.1 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(C#N)cc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL281756 | 106024 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 596 | 8 | 0 | 6 | 7.1 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(C#N)cc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 11050689 | 109044 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 678 | 15 | 4 | 10 | 3.8 | CN(C)CCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(N/N=C(\S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL303258 | 109044 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 678 | 15 | 4 | 10 | 3.8 | CN(C)CCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(N/N=C(\S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 44276375 | 103495 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 585 | 9 | 0 | 5 | 7.4 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)Cc5ccccc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL26422 | 103495 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 585 | 9 | 0 | 5 | 7.4 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)Cc5ccccc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 44276380 | 106195 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 577 | 8 | 0 | 6 | 7.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5cccs5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL28282 | 106195 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 577 | 8 | 0 | 6 | 7.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5cccs5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 44320404 | 19895 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 581 | 18 | 3 | 2 | 8.5 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccccc2)N/C(=N/C(C)C)NC(C)C)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1190474 | 19895 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 581 | 18 | 3 | 2 | 8.5 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccccc2)N/C(=N/C(C)C)NC(C)C)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL540896 | 19895 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 581 | 18 | 3 | 2 | 8.5 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccccc2)N/C(=N/C(C)C)NC(C)C)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL5267275 | 200294 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 1250 | 30 | 18 | 17 | -5.6 | N=C(N)NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@]12Cc1ccccc1CN(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C2=O | 10.1021/acs.jmedchem.6b01029 | ||
| 11679144 | 84071 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 552 | 10 | 3 | 6 | 4.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCN)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL208223 | 84071 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 552 | 10 | 3 | 6 | 4.3 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCN)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11636121 | 145789 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 564 | 7 | 2 | 6 | 4.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCCNCC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL378567 | 145789 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 564 | 7 | 2 | 6 | 4.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCCNCC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 44412412 | 175564 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 550 | 7 | 2 | 6 | 3.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCNCC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL437491 | 175564 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 550 | 7 | 2 | 6 | 3.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCNCC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 44346682 | 21015 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 696 | 18 | 2 | 1 | 12.3 | CCCC[PH](CCCC)(CCCC)Cc1ccc(/C=C/[C@H](Cc2ccc3ccccc3c2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1162798 | 21015 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 696 | 18 | 2 | 1 | 12.3 | CCCC[PH](CCCC)(CCCC)Cc1ccc(/C=C/[C@H](Cc2ccc3ccccc3c2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1199421 | 21015 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 696 | 18 | 2 | 1 | 12.3 | CCCC[PH](CCCC)(CCCC)Cc1ccc(/C=C/[C@H](Cc2ccc3ccccc3c2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 44320404 | 21121 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 582 | 18 | 3 | 2 | 8.2 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccccc2)N/C(=N/C(C)C)NC(C)C)cc1 | 10.1021/jm00069a021 | ||
| CHEMBL1162590 | 21121 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 582 | 18 | 3 | 2 | 8.2 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccccc2)N/C(=N/C(C)C)NC(C)C)cc1 | 10.1021/jm00069a021 | ||
| CHEMBL1200093 | 21121 | 0 | None | - | 1 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 582 | 18 | 3 | 2 | 8.2 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccccc2)N/C(=N/C(C)C)NC(C)C)cc1 | 10.1021/jm00069a021 | ||
| CHEMBL5268614 | 200354 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 1024 | 24 | 13 | 13 | -3.9 | N=C(N)NCCCC(NC(=O)CN1CCCCC2(CCCN2C(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCNC(=N)N)C1=O)C(=O)O | 10.1021/acs.jmedchem.6b01029 | ||
| 11707528 | 84546 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 621 | 11 | 2 | 7 | 4.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCN4CCN(C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL209117 | 84546 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 621 | 11 | 2 | 7 | 4.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCN4CCN(C)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL5284537 | 201036 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 1032 | 25 | 14 | 13 | -4.2 | N=C(N)NCCC[C@H](NC(=O)CN1Cc2ccccc2C[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCNC(=N)N)C1=O)C(=O)O | 10.1021/acs.jmedchem.6b01029 | ||
| 11657717 | 146845 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 594 | 10 | 2 | 7 | 3.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCN4CCOCC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL380045 | 146845 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 594 | 10 | 2 | 7 | 3.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCN4CCOCC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10876210 | 85359 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 691 | 13 | 4 | 8 | 4.5 | CN(C)CCCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c(Cl)c1 | 10.1021/jm0111088 | ||
| CHEMBL2112219 | 85359 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 691 | 13 | 4 | 8 | 4.5 | CN(C)CCCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(NNC(=O)NC2c3ccccc3CCc3ccccc32)c(Cl)c1 | 10.1021/jm0111088 | ||
| 44346347 | 17021 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 547 | 7 | 3 | 3 | 7.1 | O=C(Nc1cccc2ccncc12)[C@@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1160970 | 17021 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 547 | 7 | 3 | 3 | 7.1 | O=C(Nc1cccc2ccncc12)[C@@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| 44346416 | 19874 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 667 | 18 | 3 | 3 | 10.4 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2cccs2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1190354 | 19874 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 667 | 18 | 3 | 3 | 10.4 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2cccs2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL540641 | 19874 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 667 | 18 | 3 | 3 | 10.4 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2cccs2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL2370042 | 216554 | 0 | None | - | 1 | Guinea pig | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | None | None | None | CN(C(=O)CNC(=O)[C@@H]1C[C@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm00069a016 | ||||
| 44337466 | 12187 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 267 | 4 | 0 | 4 | 0.6 | CCCN1CN(CC(C)=O)C(=O)C12CCN(C)CC2 | 10.1021/jm950676i | ||
| CHEMBL107234 | 12187 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 267 | 4 | 0 | 4 | 0.6 | CCCN1CN(CC(C)=O)C(=O)C12CCN(C)CC2 | 10.1021/jm950676i | ||
| 44276482 | 106279 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 624 | 10 | 0 | 6 | 7.9 | CCCn1c(CC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)ccc1C(=O)c1ccc(C#N)cc1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL283295 | 106279 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 624 | 10 | 0 | 6 | 7.9 | CCCn1c(CC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)ccc1C(=O)c1ccc(C#N)cc1 | 10.1016/s0960-894x(03)00104-5 | ||
| 44346410 | 20555 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 701 | 18 | 4 | 2 | 10.8 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2c[nH]c3ccccc23)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1195448 | 20555 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 701 | 18 | 4 | 2 | 10.8 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2c[nH]c3ccccc23)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL554593 | 20555 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 701 | 18 | 4 | 2 | 10.8 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2c[nH]c3ccccc23)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 44215784 | 106774 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 566 | 8 | 0 | 6 | 6.6 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(Cl)nc5)n4C)c3C)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL286710 | 106774 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 566 | 8 | 0 | 6 | 6.6 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(Cl)nc5)n4C)c3C)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 44276513 | 106746 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 638 | 11 | 0 | 6 | 8.3 | CCCCn1c(CC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)ccc1C(=O)c1ccc(C#N)cc1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL286520 | 106746 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 638 | 11 | 0 | 6 | 8.3 | CCCCn1c(CC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)ccc1C(=O)c1ccc(C#N)cc1 | 10.1016/s0960-894x(03)00104-5 | ||
| 57395311 | 74453 | 0 | None | 2 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 580 | 7 | 4 | 7 | 2.9 | NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=S)NC2Cc3ccccc3Cc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL1907655 | 74453 | 0 | None | 2 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 580 | 7 | 4 | 7 | 2.9 | NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=S)NC2Cc3ccccc3Cc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 44214279 | 16488 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 489 | 8 | 1 | 5 | 5.3 | C=C/C=C/C(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccc3sc(C)nc23)c1Cl | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113222 | 16488 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 489 | 8 | 1 | 5 | 5.3 | C=C/C=C/C(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccc3sc(C)nc23)c1Cl | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL5268547 | 200349 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1250 | 30 | 18 | 17 | -5.6 | N=C(N)NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@]12Cc1ccccc1CN(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C2=O | 10.1021/acs.jmedchem.6b01029 | ||
| 15388873 | 121509 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 529 | 8 | 1 | 6 | 5.9 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccco4)c3Cl)cccc2s1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL333832 | 121509 | 0 | None | - | 1 | Guinea pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 529 | 8 | 1 | 6 | 5.9 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccco4)c3Cl)cccc2s1 | 10.1016/s0960-894x(98)00736-7 | ||
| 44341214 | 117207 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 621 | 12 | 1 | 6 | 6.7 | CCCOc1c(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)ccc(OC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL324575 | 117207 | 0 | None | - | 1 | Guinea pig | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 621 | 12 | 1 | 6 | 6.7 | CCCOc1c(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)ccc(OC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| 11506007 | 84786 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 676 | 9 | 2 | 8 | 3.1 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)CN5CCNCC5)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL209773 | 84786 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 676 | 9 | 2 | 8 | 3.1 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=O)CN5CCNCC5)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10008626 | 145456 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 592 | 7 | 3 | 6 | 3.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=N)N)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL377800 | 145456 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 592 | 7 | 3 | 6 | 3.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N4CCN(C(=N)N)CC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL2370028 | 216549 | 0 | None | - | 1 | Guinea pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | None | None | None | CN(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(=O)[C@@H]1C[C@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N | 10.1021/jm00069a016 | ||||
| 22288562 | 169733 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 586 | 8 | 1 | 6 | 6.8 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(N)cc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL417474 | 169733 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 586 | 8 | 1 | 6 | 6.8 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(N)cc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL2370035 | 216550 | 0 | None | - | 1 | Guinea pig | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | None | None | None | CC(NC(=O)[C@@H]1C[C@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm00069a016 | ||||
| 44276439 | 103739 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 546 | 9 | 0 | 6 | 6.3 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CCc4ccc(C(=O)c5cccnc5)n4C)c3C)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL26629 | 103739 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 546 | 9 | 0 | 6 | 6.3 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)CCc4ccc(C(=O)c5cccnc5)n4C)c3C)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 44276474 | 104166 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 591 | 9 | 0 | 6 | 7.7 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CCc4ccc(C(=O)c5cccs5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL26976 | 104166 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 591 | 9 | 0 | 6 | 7.7 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CCc4ccc(C(=O)c5cccs5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 10504589 | 63951 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 471 | 9 | 4 | 6 | 3.5 | O=[N+]([O-])c1cc(S(=O)(=O)NCc2ccccc2)ccc1N/N=C(/S)NCc1ccccc1 | 10.1021/jm991155o | ||
| CHEMBL164848 | 63951 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 471 | 9 | 4 | 6 | 3.5 | O=[N+]([O-])c1cc(S(=O)(=O)NCc2ccccc2)ccc1N/N=C(/S)NCc1ccccc1 | 10.1021/jm991155o | ||
| 44346389 | 17024 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 497 | 7 | 3 | 3 | 6.0 | O=C(Nc1cccnc1)[C@@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1160975 | 17024 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 497 | 7 | 3 | 3 | 6.0 | O=C(Nc1cccnc1)[C@@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL5266183 | 200251 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 1210 | 31 | 19 | 17 | -6.4 | N=C(N)NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@@H]1Cc2ccccc2CN(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C1=O | 10.1021/acs.jmedchem.6b01029 | ||
| 11614670 | 84429 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 618 | 13 | 3 | 7 | 5.4 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4ccoc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL208859 | 84429 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 618 | 13 | 3 | 7 | 5.4 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4ccoc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11571204 | 145488 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 592 | 10 | 2 | 6 | 5.1 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCN4CCCCC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL377966 | 145488 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 592 | 10 | 2 | 6 | 5.1 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCN4CCCCC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 44410526 | 90031 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 1332 | 32 | 16 | 17 | -4.3 | NC(N)=NCCC[C@H](NC(=O)[C@@H]1CC2(CCCC2)C2CCC[C@@](Cc3ccccc3)(NC(=O)[C@H](CO)NC(=O)[C@H](Cc3cccs3)NC(=O)CNC(=O)[C@@H]3CC(O)CN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N21)C(=O)O | 10.1016/j.bmcl.2006.01.125 | ||
| CHEMBL218749 | 90031 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 1332 | 32 | 16 | 17 | -4.3 | NC(N)=NCCC[C@H](NC(=O)[C@@H]1CC2(CCCC2)C2CCC[C@@](Cc3ccccc3)(NC(=O)[C@H](CO)NC(=O)[C@H](Cc3cccs3)NC(=O)CNC(=O)[C@@H]3CC(O)CN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N21)C(=O)O | 10.1016/j.bmcl.2006.01.125 | ||
| 44316621 | 88891 | 0 | None | -57 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 1091 | 24 | 13 | 15 | -4.9 | NC(N)=NCCCC(N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)NC(C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O)C1Cc2ccccc2C1 | 10.1021/jm990961s | ||
| CHEMBL216618 | 88891 | 0 | None | -57 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 1091 | 24 | 13 | 15 | -4.9 | NC(N)=NCCCC(N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)NC(C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O)C1Cc2ccccc2C1 | 10.1021/jm990961s | ||
| 101653256 | 19875 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 661 | 18 | 3 | 2 | 10.4 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccccc2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 44320170 | 19875 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 661 | 18 | 3 | 2 | 10.4 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccccc2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1190355 | 19875 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 661 | 18 | 3 | 2 | 10.4 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccccc2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL540642 | 19875 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 661 | 18 | 3 | 2 | 10.4 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccccc2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 44298960 | 202417 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 563 | 9 | 2 | 6 | 5.9 | CC(=O)Nc1ccc(/C=C/C(=O)NC[C@@H]2CCCN2c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cn1 | 10.1016/s0960-894x(03)00309-3 | ||
| CHEMBL55632 | 202417 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 563 | 9 | 2 | 6 | 5.9 | CC(=O)Nc1ccc(/C=C/C(=O)NC[C@@H]2CCCN2c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cn1 | 10.1016/s0960-894x(03)00309-3 | ||
| 44346104 | 18196 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 643 | 28 | 0 | 0 | 15.0 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc2cc(C[P+](CCCCC)(CCCCC)CCCCC)ccc2c1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1180289 | 18196 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 643 | 28 | 0 | 0 | 15.0 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc2cc(C[P+](CCCCC)(CCCCC)CCCCC)ccc2c1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL120282 | 18196 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 643 | 28 | 0 | 0 | 15.0 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc2cc(C[P+](CCCCC)(CCCCC)CCCCC)ccc2c1 | 10.1016/0960-894X(95)00035-R | ||
| 44320170 | 21064 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 663 | 18 | 3 | 2 | 10.1 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccccc2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1021/jm00069a021 | ||
| CHEMBL1162585 | 21064 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 663 | 18 | 3 | 2 | 10.1 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccccc2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1021/jm00069a021 | ||
| CHEMBL1199851 | 21064 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 663 | 18 | 3 | 2 | 10.1 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccccc2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1021/jm00069a021 | ||
| 22288578 | 105888 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 649 | 9 | 0 | 7 | 6.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(S(C)(=O)=O)cc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL280869 | 105888 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 649 | 9 | 0 | 7 | 6.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(S(C)(=O)=O)cc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 10930680 | 74452 | 0 | None | -6 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 750 | 15 | 4 | 9 | 4.7 | CN(C)CCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(N/N=C(\S)NC(c2ccccc2Cl)c2ccccc2Cl)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL1907654 | 74452 | 0 | None | -6 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 750 | 15 | 4 | 9 | 4.7 | CN(C)CCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(N/N=C(\S)NC(c2ccccc2Cl)c2ccccc2Cl)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 10100960 | 23261 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 669 | 29 | 0 | 0 | 15.5 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(-c2ccc(C[P+](CCCCC)(CCCCC)CCCCC)cc2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL123548 | 23261 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 669 | 29 | 0 | 0 | 15.5 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(-c2ccc(C[P+](CCCCC)(CCCCC)CCCCC)cc2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL333705 | 23261 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 669 | 29 | 0 | 0 | 15.5 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(-c2ccc(C[P+](CCCCC)(CCCCC)CCCCC)cc2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL539629 | 23261 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 669 | 29 | 0 | 0 | 15.5 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(-c2ccc(C[P+](CCCCC)(CCCCC)CCCCC)cc2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 10100960 | 23261 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 669 | 29 | 0 | 0 | 15.5 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(-c2ccc(C[P+](CCCCC)(CCCCC)CCCCC)cc2)cc1 | 10.1016/0960-894X(95)00036-S | ||
| CHEMBL123548 | 23261 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 669 | 29 | 0 | 0 | 15.5 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(-c2ccc(C[P+](CCCCC)(CCCCC)CCCCC)cc2)cc1 | 10.1016/0960-894X(95)00036-S | ||
| CHEMBL333705 | 23261 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 669 | 29 | 0 | 0 | 15.5 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(-c2ccc(C[P+](CCCCC)(CCCCC)CCCCC)cc2)cc1 | 10.1016/0960-894X(95)00036-S | ||
| CHEMBL539629 | 23261 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 669 | 29 | 0 | 0 | 15.5 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(-c2ccc(C[P+](CCCCC)(CCCCC)CCCCC)cc2)cc1 | 10.1016/0960-894X(95)00036-S | ||
| 44346418 | 20530 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 697 | 17 | 3 | 2 | 11.6 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)C(N/C(=N/C2CCCCC2)NC2CCCCC2)c2ccc3ccccc3c2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1195322 | 20530 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 697 | 17 | 3 | 2 | 11.6 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)C(N/C(=N/C2CCCCC2)NC2CCCCC2)c2ccc3ccccc3c2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL554254 | 20530 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 697 | 17 | 3 | 2 | 11.6 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)C(N/C(=N/C2CCCCC2)NC2CCCCC2)c2ccc3ccccc3c2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 11215913 | 143317 | 0 | None | -26915 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 646 | 9 | 2 | 6 | 4.9 | CN1c2cc(CN3CCCCC3)ccc2[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O | 10.1021/jm061224g | ||
| CHEMBL373654 | 143317 | 0 | None | -26915 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 646 | 9 | 2 | 6 | 4.9 | CN1c2cc(CN3CCCCC3)ccc2[C@@H](NC(=O)C[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc2)CS1(=O)=O | 10.1021/jm061224g | ||
| 44276975 | 103290 | 0 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 1081 | 34 | 13 | 12 | -0.8 | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1CCc2ccccc2C1C(=O)N1CC(C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C2CCCCC21 | 10.1021/jm00035a015 | ||
| CHEMBL262639 | 103290 | 0 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 1081 | 34 | 13 | 12 | -0.8 | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1CCc2ccccc2C1C(=O)N1CC(C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C2CCCCC21 | 10.1021/jm00035a015 | ||
| 90663066 | 113365 | 0 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 1081 | 34 | 14 | 12 | -0.5 | N=C(N)NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1CCc2ccccc2[C@@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1016/S0960-894X(97)10042-7 | ||
| CHEMBL3142595 | 113365 | 0 | None | - | 1 | Guinea pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 1081 | 34 | 14 | 12 | -0.5 | N=C(N)NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)NCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1CCc2ccccc2[C@@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1016/S0960-894X(97)10042-7 | ||
| 22288581 | 106059 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 582 | 8 | 1 | 5 | 7.1 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(C#N)cc5)[nH]4)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL281951 | 106059 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 582 | 8 | 1 | 5 | 7.1 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(C#N)cc5)[nH]4)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 9830551 | 106824 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 620 | 9 | 0 | 6 | 7.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CCc4ccc(C(=O)c5ccc(Cl)nc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL287018 | 106824 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 620 | 9 | 0 | 6 | 7.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CCc4ccc(C(=O)c5ccc(Cl)nc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 10571699 | 63926 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 378 | 6 | 3 | 4 | 4.6 | O=[N+]([O-])c1ccccc1N/N=C(/S)NC(c1ccccc1)c1ccccc1 | 10.1021/jm991155o | ||
| CHEMBL164636 | 63926 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 378 | 6 | 3 | 4 | 4.6 | O=[N+]([O-])c1ccccc1N/N=C(/S)NC(c1ccccc1)c1ccccc1 | 10.1021/jm991155o | ||
| 22288602 | 106505 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 624 | 10 | 0 | 6 | 7.9 | CCCN(C(=O)Cc1ccc(C(=O)c2ccc(C#N)cc2)n1C)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1Cl | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL284865 | 106505 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 624 | 10 | 0 | 6 | 7.9 | CCCN(C(=O)Cc1ccc(C(=O)c2ccc(C#N)cc2)n1C)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1Cl | 10.1016/s0960-894x(03)00104-5 | ||
| 11707423 | 84806 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 580 | 11 | 4 | 6 | 3.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCN=C(N)N)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL209873 | 84806 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 580 | 11 | 4 | 6 | 3.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCN=C(N)N)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11592927 | 146055 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 629 | 13 | 3 | 7 | 5.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4ccccn4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL379083 | 146055 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 629 | 13 | 3 | 7 | 5.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4ccccn4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11636064 | 84795 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 553 | 11 | 2 | 6 | 4.6 | COCCCNC(=O)C(C)(C)NS(=O)(=O)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1Cl | 10.1021/jm060137l | ||
| CHEMBL209819 | 84795 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 553 | 11 | 2 | 6 | 4.6 | COCCCNC(=O)C(C)(C)NS(=O)(=O)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1Cl | 10.1021/jm060137l | ||
| 11498691 | 85028 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 646 | 13 | 3 | 6 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4ccc(F)cc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL210662 | 85028 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 646 | 13 | 3 | 6 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4ccc(F)cc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 9916936 | 106487 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 610 | 9 | 0 | 6 | 7.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CCc4ccc(C(=O)c5ccc(C#N)cc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL284727 | 106487 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 610 | 9 | 0 | 6 | 7.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)CCc4ccc(C(=O)c5ccc(C#N)cc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 10790025 | 64232 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 457 | 7 | 4 | 6 | 3.2 | NS(=O)(=O)c1ccc(N/N=C(/S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm991155o | ||
| CHEMBL165627 | 64232 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 457 | 7 | 4 | 6 | 3.2 | NS(=O)(=O)c1ccc(N/N=C(/S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm991155o | ||
| 44316620 | 8902 | 0 | None | 19 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990961s | ||||
| 656 | 8902 | 0 | None | 19 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990961s | ||||
| CHEMBL408846 | 8902 | 0 | None | 19 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm990961s | ||||
| 57393602 | 74454 | 0 | None | 3 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 708 | 13 | 4 | 9 | 3.0 | CN(C)CCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=S)NC2Cc3ccccc3Cc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL1907656 | 74454 | 0 | None | 3 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 708 | 13 | 4 | 9 | 3.0 | CN(C)CCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=S)NC2Cc3ccccc3Cc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 44320168 | 17020 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 529 | 7 | 3 | 3 | 5.2 | O=C(NC1CN2CCC1CC2)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1160969 | 17020 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 529 | 7 | 3 | 3 | 5.2 | O=C(NC1CN2CCC1CC2)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL444322 | 17020 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 529 | 7 | 3 | 3 | 5.2 | O=C(NC1CN2CCC1CC2)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| 44320168 | 17020 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 529 | 7 | 3 | 3 | 5.2 | O=C(NC1CN2CCC1CC2)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1021/jm00069a021 | ||
| CHEMBL1160969 | 17020 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 529 | 7 | 3 | 3 | 5.2 | O=C(NC1CN2CCC1CC2)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1021/jm00069a021 | ||
| CHEMBL444322 | 17020 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 529 | 7 | 3 | 3 | 5.2 | O=C(NC1CN2CCC1CC2)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1021/jm00069a021 | ||
| 44346412 | 19872 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 717 | 18 | 3 | 3 | 11.6 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2cc3ccccc3s2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1190352 | 19872 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 717 | 18 | 3 | 3 | 11.6 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2cc3ccccc3s2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL540639 | 19872 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 717 | 18 | 3 | 3 | 11.6 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2cc3ccccc3s2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 70688994 | 84226 | 0 | None | -18 | 2 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 433 | 5 | 2 | 4 | 2.6 | Cc1c(Cl)ccc(S(=O)(=O)N2CCC[C@H]2C(=O)NCC2CCNCC2)c1Cl | 10.1021/jm2016057 | ||
| CHEMBL2087028 | 84226 | 0 | None | -18 | 2 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 433 | 5 | 2 | 4 | 2.6 | Cc1c(Cl)ccc(S(=O)(=O)N2CCC[C@H]2C(=O)NCC2CCNCC2)c1Cl | 10.1021/jm2016057 | ||
| 44276459 | 103132 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 652 | 11 | 0 | 6 | 8.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(C#N)cc5)n4CCC(C)C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL26160 | 103132 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 652 | 11 | 0 | 6 | 8.6 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(C#N)cc5)n4CCC(C)C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 90663068 | 113366 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 1095 | 35 | 13 | 12 | -0.3 | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1CCc2ccccc2[C@@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1016/S0960-894X(97)10042-7 | ||
| CHEMBL3142597 | 113366 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 1095 | 35 | 13 | 12 | -0.3 | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N1CCc2ccccc2[C@@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1016/S0960-894X(97)10042-7 | ||
| 44340964 | 16479 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 609 | 10 | 1 | 6 | 6.7 | COc1c(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)ccc(SC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113176 | 16479 | 0 | None | - | 1 | Guinea pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 609 | 10 | 1 | 6 | 6.7 | COc1c(N(C)C(=O)CNC(=O)/C=C/c2ccc(C(F)(F)F)cc2)ccc(SC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| 10482991 | 107426 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 563 | 9 | 2 | 6 | 5.9 | CC(=O)Nc1ccc(/C=C/C(=O)NC[C@H]2CCCN2c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cn1 | 10.1016/s0960-894x(03)00309-3 | ||
| CHEMBL292181 | 107426 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 563 | 9 | 2 | 6 | 5.9 | CC(=O)Nc1ccc(/C=C/C(=O)NC[C@H]2CCCN2c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cn1 | 10.1016/s0960-894x(03)00309-3 | ||
| 44346414 | 20531 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 676 | 19 | 3 | 2 | 10.7 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](CCc2ccccc2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1195323 | 20531 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 676 | 19 | 3 | 2 | 10.7 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](CCc2ccccc2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL554255 | 20531 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 676 | 19 | 3 | 2 | 10.7 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](CCc2ccccc2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 44276666 | 105393 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 639 | 8 | 0 | 5 | 8.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(C(F)(F)F)cc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL27701 | 105393 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 639 | 8 | 0 | 5 | 8.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(C(F)(F)F)cc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 44355289 | 168683 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 1134 | 31 | 16 | 17 | -8.4 | NC(N)=NCCC[C@H](NC(=O)CN1CC[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1=O)C(=O)O | 10.1021/jm9901531 | ||
| CHEMBL415209 | 168683 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 1134 | 31 | 16 | 17 | -8.4 | NC(N)=NCCC[C@H](NC(=O)CN1CC[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1=O)C(=O)O | 10.1021/jm9901531 | ||
| 16108960 | 176038 | 0 | None | -30902 | 2 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 567 | 9 | 2 | 4 | 6.0 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL441188 | 176038 | 0 | None | -30902 | 2 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 567 | 9 | 2 | 4 | 6.0 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| 44300140 | 108386 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 526 | 8 | 4 | 3 | 6.1 | O=C(Nc1ccc(CO)cc1)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL298832 | 108386 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 526 | 8 | 4 | 3 | 6.1 | O=C(Nc1ccc(CO)cc1)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| 44214619 | 117382 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 553 | 13 | 1 | 8 | 4.7 | COC(=O)CCCCC(=O)NCC(=O)N(C)c1ccc(OC)c(COc2cccc3ccc(C)nc23)c1SC | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL325601 | 117382 | 0 | None | - | 1 | Guinea pig | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 553 | 13 | 1 | 8 | 4.7 | COC(=O)CCCCC(=O)NCC(=O)N(C)c1ccc(OC)c(COc2cccc3ccc(C)nc23)c1SC | 10.1016/s0960-894x(98)00736-7 | ||
| 10930680 | 74452 | 0 | None | 6 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 750 | 15 | 4 | 9 | 4.7 | CN(C)CCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(N/N=C(\S)NC(c2ccccc2Cl)c2ccccc2Cl)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL1907654 | 74452 | 0 | None | 6 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 750 | 15 | 4 | 9 | 4.7 | CN(C)CCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(N/N=C(\S)NC(c2ccccc2Cl)c2ccccc2Cl)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL5278855 | 200780 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1046 | 25 | 14 | 13 | -3.8 | C[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)N1Cc2ccccc2C[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCNC(=N)N)C1=O | 10.1021/acs.jmedchem.6b01029 | ||
| 44276716 | 106486 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 622 | 10 | 0 | 6 | 7.6 | C=CCN(C(=O)Cc1ccc(C(=O)c2ccc(C#N)cc2)n1C)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1Cl | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL284726 | 106486 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 622 | 10 | 0 | 6 | 7.6 | C=CCN(C(=O)Cc1ccc(C(=O)c2ccc(C#N)cc2)n1C)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1Cl | 10.1016/s0960-894x(03)00104-5 | ||
| 44355287 | 168658 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1162 | 31 | 16 | 17 | -7.6 | NC(N)=NCCC[C@H](NC(=O)CN1CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1=O)C(=O)O | 10.1021/jm9901531 | ||
| CHEMBL415032 | 168658 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1162 | 31 | 16 | 17 | -7.6 | NC(N)=NCCC[C@H](NC(=O)CN1CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1=O)C(=O)O | 10.1021/jm9901531 | ||
| 122189855 | 130190 | 0 | None | -75 | 3 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 1816 | 45 | 23 | 23 | -3.5 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)CC1C(=O)NCC(=O)NC(Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1C(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)CC2CCCCC21 | 10.1016/j.bmcl.2015.08.014 | ||
| CHEMBL3616879 | 130190 | 0 | None | -75 | 3 | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 1816 | 45 | 23 | 23 | -3.5 | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)CC1C(=O)NCC(=O)NC(Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1C(C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)CC2CCCCC21 | 10.1016/j.bmcl.2015.08.014 | ||
| 44346361 | 17022 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 536 | 7 | 4 | 3 | 6.5 | O=C(Nc1nc2ccccc2[nH]1)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1160971 | 17022 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 536 | 7 | 4 | 3 | 6.5 | O=C(Nc1nc2ccccc2[nH]1)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| 10742229 | 127047 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 451 | 9 | 4 | 8 | 2.7 | O=[N+]([O-])c1cc(S(=O)(=O)NCc2ccco2)ccc1N/N=C(/S)NCc1ccco1 | 10.1021/jm991155o | ||
| CHEMBL352459 | 127047 | 0 | None | - | 1 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 451 | 9 | 4 | 8 | 2.7 | O=[N+]([O-])c1cc(S(=O)(=O)NCc2ccco2)ccc1N/N=C(/S)NCc1ccco1 | 10.1021/jm991155o | ||
| 44276455 | 105153 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 610 | 9 | 0 | 6 | 7.5 | CCN(C(=O)Cc1ccc(C(=O)c2ccc(C#N)cc2)n1C)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1Cl | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL27530 | 105153 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 610 | 9 | 0 | 6 | 7.5 | CCN(C(=O)Cc1ccc(C(=O)c2ccc(C#N)cc2)n1C)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1Cl | 10.1016/s0960-894x(03)00104-5 | ||
| 44346306 | 17019 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 529 | 7 | 3 | 3 | 5.2 | O=C(NC1CN2CCC1CC2)C(Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1160968 | 17019 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 529 | 7 | 3 | 3 | 5.2 | O=C(NC1CN2CCC1CC2)C(Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1016/0960-894X(95)00035-R | ||
| 44320168 | 17020 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 529 | 7 | 3 | 3 | 5.2 | O=C(NC1CN2CCC1CC2)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1021/jm00069a021 | ||
| CHEMBL1160969 | 17020 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 529 | 7 | 3 | 3 | 5.2 | O=C(NC1CN2CCC1CC2)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1021/jm00069a021 | ||
| CHEMBL444322 | 17020 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 529 | 7 | 3 | 3 | 5.2 | O=C(NC1CN2CCC1CC2)[C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1 | 10.1021/jm00069a021 | ||
| 44276487 | 106775 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 582 | 8 | 1 | 6 | 7.1 | Cc1ccc2cccc(OCc3c(Cl)ccc(NC(=O)Cc4ccc(C(=O)c5ccc(C#N)cc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL286711 | 106775 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 582 | 8 | 1 | 6 | 7.1 | Cc1ccc2cccc(OCc3c(Cl)ccc(NC(=O)Cc4ccc(C(=O)c5ccc(C#N)cc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 16108967 | 91119 | 0 | None | -147 | 2 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 541 | 10 | 2 | 4 | 5.6 | O=C(CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1 | 10.1021/jm061224g | ||
| CHEMBL221691 | 91119 | 0 | None | -147 | 2 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 541 | 10 | 2 | 4 | 5.6 | O=C(CC(NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)NCc1ccc(CN2CCCCC2)cc1 | 10.1021/jm061224g | ||
| 10461651 | 106149 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 628 | 9 | 1 | 6 | 7.2 | CC(=O)Nc1ccc(C(=O)c2ccc(CC(=O)N(C)c3ccc(Cl)c(COc4cccc5ccc(C)nc45)c3Cl)n2C)cc1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL282562 | 106149 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 628 | 9 | 1 | 6 | 7.2 | CC(=O)Nc1ccc(C(=O)c2ccc(CC(=O)N(C)c3ccc(Cl)c(COc4cccc5ccc(C)nc45)c3Cl)n2C)cc1 | 10.1016/s0960-894x(03)00104-5 | ||
| 16108969 | 89806 | 0 | None | -239883 | 2 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 581 | 9 | 2 | 4 | 6.4 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL218152 | 89806 | 0 | None | -239883 | 2 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 581 | 9 | 2 | 4 | 6.4 | O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc21 | 10.1021/jm061224g | ||
| CHEMBL5271423 | 200462 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 1312 | 30 | 18 | 17 | -4.6 | N=C(N)NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1021/acs.jmedchem.6b01029 | ||
| CHEMBL3038105 | 217717 | 0 | None | 3 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N(CC(=O)N1C2CCCCC2C[C@H]1C(=O)O)Cc1ccccc1 | 10.1021/jm950716i | ||||
| 71450888 | 85568 | 0 | None | -8 | 2 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1228 | 31 | 16 | 18 | -6.5 | NC(N)=NCCC[C@H](NC(=O)CN1C(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)CSc2ccccc21)C(=O)O | 10.1021/jm9901529 | ||
| CHEMBL2112698 | 85568 | 0 | None | -8 | 2 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1228 | 31 | 16 | 18 | -6.5 | NC(N)=NCCC[C@H](NC(=O)CN1C(=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)CSc2ccccc21)C(=O)O | 10.1021/jm9901529 | ||
| 44355234 | 103233 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1242 | 31 | 16 | 18 | -6.2 | Cc1ccc2c(c1)SCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cccs1)NC(=O)CNC(=O)[C@@H]1CC(O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N2CC(=O)N[C@H](CCCN=C(N)N)C(=O)O | 10.1021/jm9901531 | ||
| CHEMBL262313 | 103233 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1242 | 31 | 16 | 18 | -6.2 | Cc1ccc2c(c1)SCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cccs1)NC(=O)CNC(=O)[C@@H]1CC(O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N2CC(=O)N[C@H](CCCN=C(N)N)C(=O)O | 10.1021/jm9901531 | ||
| 22008916 | 16534 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 461 | 8 | 2 | 6 | 3.3 | CCNC(=O)NCC(=O)N(C)c1ccc(OC)c(COc2cccc3ccc(C)nc23)c1C#N | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL113502 | 16534 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 461 | 8 | 2 | 6 | 3.3 | CCNC(=O)NCC(=O)N(C)c1ccc(OC)c(COc2cccc3ccc(C)nc23)c1C#N | 10.1016/s0960-894x(98)00736-7 | ||
| 44337425 | 116654 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 315 | 3 | 0 | 4 | 1.7 | CC(=O)CN1CN(c2ccc(C)cc2)C2(CCN(C)CC2)C1=O | 10.1021/jm950676i | ||
| CHEMBL323421 | 116654 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 315 | 3 | 0 | 4 | 1.7 | CC(=O)CN1CN(c2ccc(C)cc2)C2(CCN(C)CC2)C1=O | 10.1021/jm950676i | ||
| 44340951 | 16774 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 587 | 11 | 1 | 7 | 6.4 | COc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(SC)c(COc3cccc4ccc(C)nc34)c2SC)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL114915 | 16774 | 0 | None | - | 1 | Guinea pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 587 | 11 | 1 | 7 | 6.4 | COc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(SC)c(COc3cccc4ccc(C)nc34)c2SC)cc1 | 10.1016/s0960-894x(98)00736-7 | ||
| 44337476 | 14900 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 321 | 4 | 0 | 4 | 1.7 | CC(=O)CN1CN(CC2CCCCC2)C2(CCN(C)CC2)C1=O | 10.1021/jm950676i | ||
| CHEMBL109172 | 14900 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 321 | 4 | 0 | 4 | 1.7 | CC(=O)CN1CN(CC2CCCCC2)C2(CCN(C)CC2)C1=O | 10.1021/jm950676i | ||
| 132927 | 10856 | 4 | None | 6 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 10.1016/0960-894X(95)00035-R | ||
| 138398059 | 10856 | 4 | None | 6 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 10.1016/0960-894X(95)00035-R | ||
| 677 | 10856 | 4 | None | 6 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL294453 | 10856 | 4 | None | 6 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL551291 | 10856 | 4 | None | 6 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 10.1016/0960-894X(95)00035-R | ||
| 101005081 | 19873 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 754 | 21 | 3 | 2 | 12.7 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 44346317 | 19873 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 754 | 21 | 3 | 2 | 12.7 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1190353 | 19873 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 754 | 21 | 3 | 2 | 12.7 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL540640 | 19873 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 754 | 21 | 3 | 2 | 12.7 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 132928 | 21069 | 4 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 713 | 18 | 3 | 2 | 11.2 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00036-S | ||
| CHEMBL1162586 | 21069 | 4 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 713 | 18 | 3 | 2 | 11.2 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00036-S | ||
| CHEMBL1199865 | 21069 | 4 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 713 | 18 | 3 | 2 | 11.2 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00036-S | ||
| 132928 | 21069 | 4 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 713 | 18 | 3 | 2 | 11.2 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1021/jm00069a021 | ||
| CHEMBL1162586 | 21069 | 4 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 713 | 18 | 3 | 2 | 11.2 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1021/jm00069a021 | ||
| CHEMBL1199865 | 21069 | 4 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 713 | 18 | 3 | 2 | 11.2 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1021/jm00069a021 | ||
| 90662943 | 113361 | 0 | None | -1778 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 1192 | 30 | 14 | 17 | -4.3 | NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O)C1Cc2ccccc2C1 | 10.1021/jm990961s | ||
| CHEMBL3142391 | 113361 | 0 | None | -1778 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 1192 | 30 | 14 | 17 | -4.3 | NCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O)C1Cc2ccccc2C1 | 10.1021/jm990961s | ||
| 11650337 | 145465 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 523 | 7 | 3 | 5 | 3.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N=C(N)N)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL377835 | 145465 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 523 | 7 | 3 | 5 | 3.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)N=C(N)N)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11542210 | 84384 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 608 | 11 | 2 | 7 | 4.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCN4CCOCC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL208807 | 84384 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 608 | 11 | 2 | 7 | 4.3 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCN4CCOCC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11136263 | 85361 | 0 | None | -43 | 2 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 704 | 13 | 4 | 10 | 3.9 | CN(C)CCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(N/N=C(\S)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL2112221 | 85361 | 0 | None | -43 | 2 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 704 | 13 | 4 | 10 | 3.9 | CN(C)CCN(C)CCNC(=O)c1cccn1S(=O)(=O)c1ccc(N/N=C(\S)NC2c3ccccc3CCc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 10952583 | 74455 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 694 | 14 | 4 | 9 | 3.7 | CN(C)CCCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(N/N=C(\S)NC2c3ccccc3-c3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL1907657 | 74455 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 694 | 14 | 4 | 9 | 3.7 | CN(C)CCCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(N/N=C(\S)NC2c3ccccc3-c3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 57395311 | 74453 | 0 | None | -2 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 580 | 7 | 4 | 7 | 2.9 | NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=S)NC2Cc3ccccc3Cc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL1907655 | 74453 | 0 | None | -2 | 2 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 580 | 7 | 4 | 7 | 2.9 | NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=S)NC2Cc3ccccc3Cc3ccccc32)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 9915727 | 102300 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 556 | 8 | 0 | 6 | 6.4 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(C#N)cc5)n4C)c3C)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL25745 | 102300 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 556 | 8 | 0 | 6 | 6.4 | Cc1ccc2cccc(OCc3c(C)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(C#N)cc5)n4C)c3C)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 10886849 | 74451 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 655 | 14 | 4 | 7 | 3.5 | CN(C)CCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=O)NC(c2ccccc2)c2ccccc2)c(Cl)c1 | 10.1021/jm0111088 | ||
| CHEMBL1907653 | 74451 | 0 | None | - | 1 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 655 | 14 | 4 | 7 | 3.5 | CN(C)CCN(C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(NNC(=O)NC(c2ccccc2)c2ccccc2)c(Cl)c1 | 10.1021/jm0111088 | ||
| 44337489 | 16002 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 301 | 3 | 0 | 4 | 1.3 | CC(=O)CN1CN(c2ccccc2)C2(CCN(C)CC2)C1=O | 10.1021/jm950676i | ||
| CHEMBL110652 | 16002 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 301 | 3 | 0 | 4 | 1.3 | CC(=O)CN1CN(c2ccccc2)C2(CCN(C)CC2)C1=O | 10.1021/jm950676i | ||
| CHEMBL2392354 | 217194 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | N=C(N)NCCC[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O | 10.1016/j.ejmech.2013.01.044 | ||||
| 11527906 | 146896 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 670 | 13 | 5 | 7 | 5.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNc4ccc(C(=N)N)cc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL380086 | 146896 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 670 | 13 | 5 | 7 | 5.7 | Cc1cc(C)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNc4ccc(C(=N)N)cc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 45266122 | 19877 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 726 | 18 | 2 | 2 | 11.9 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N(C)/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1190357 | 19877 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 726 | 18 | 2 | 2 | 11.9 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N(C)/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL540644 | 19877 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 726 | 18 | 2 | 2 | 11.9 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N(C)/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 44346679 | 19894 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 631 | 18 | 3 | 2 | 9.7 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N/C(=N/C(C)C)NC(C)C)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1190473 | 19894 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 631 | 18 | 3 | 2 | 9.7 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N/C(=N/C(C)C)NC(C)C)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL540895 | 19894 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 631 | 18 | 3 | 2 | 9.7 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)[C@H](Cc2ccc3ccccc3c2)N/C(=N/C(C)C)NC(C)C)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 10542327 | 64187 | 0 | None | - | 1 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 301 | 5 | 2 | 3 | 3.2 | O=[N+]([O-])c1ccccc1C/N=C(\S)NCc1ccccc1 | 10.1021/jm991155o | ||
| CHEMBL165240 | 64187 | 0 | None | - | 1 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 301 | 5 | 2 | 3 | 3.2 | O=[N+]([O-])c1ccccc1C/N=C(\S)NCc1ccccc1 | 10.1021/jm991155o | ||
| 44276840 | 106751 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 628 | 9 | 1 | 6 | 7.2 | CC(=O)Nc1cccc(C(=O)c2ccc(CC(=O)N(C)c3ccc(Cl)c(COc4cccc5ccc(C)nc45)c3Cl)n2C)c1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL286556 | 106751 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 628 | 9 | 1 | 6 | 7.2 | CC(=O)Nc1cccc(C(=O)c2ccc(CC(=O)N(C)c3ccc(Cl)c(COc4cccc5ccc(C)nc45)c3Cl)n2C)c1 | 10.1016/s0960-894x(03)00104-5 | ||
| 44276488 | 103984 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 597 | 8 | 0 | 7 | 6.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(C#N)nc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL26847 | 103984 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 597 | 8 | 0 | 7 | 6.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(C#N)nc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 44276624 | 103627 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 605 | 8 | 0 | 5 | 7.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(Cl)cc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL26532 | 103627 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 605 | 8 | 0 | 5 | 7.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(Cl)cc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 44276599 | 103183 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 650 | 9 | 1 | 7 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(S(N)(=O)=O)cc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL26192 | 103183 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 650 | 9 | 1 | 7 | 5.9 | Cc1ccc2cccc(OCc3c(Cl)ccc(N(C)C(=O)Cc4ccc(C(=O)c5ccc(S(N)(=O)=O)cc5)n4C)c3Cl)c2n1 | 10.1016/s0960-894x(03)00104-5 | ||
| 44346387 | 21107 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 696 | 18 | 2 | 1 | 12.3 | CCCC[PH](CCCC)(CCCC)Cc1ccc(/C=C\[C@H](Cc2ccc3ccccc3c2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1162797 | 21107 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 696 | 18 | 2 | 1 | 12.3 | CCCC[PH](CCCC)(CCCC)Cc1ccc(/C=C\[C@H](Cc2ccc3ccccc3c2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1200033 | 21107 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 696 | 18 | 2 | 1 | 12.3 | CCCC[PH](CCCC)(CCCC)Cc1ccc(/C=C\[C@H](Cc2ccc3ccccc3c2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 176 | 7186 | 66 | None | -5 | 31 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
| 2157 | 7186 | 66 | None | -5 | 31 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
| 2566 | 7186 | 66 | None | -5 | 31 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
| CHEMBL633 | 7186 | 66 | None | -5 | 31 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
| DB01118 | 7186 | 66 | None | -5 | 31 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | nan | ||
| 10373002 | 145089 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 697 | 30 | 0 | 1 | 15.1 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(C(=O)c2ccc(C[P+](CCCCC)(CCCCC)CCCCC)cc2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL121565 | 145089 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 697 | 30 | 0 | 1 | 15.1 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(C(=O)c2ccc(C[P+](CCCCC)(CCCCC)CCCCC)cc2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL377100 | 145089 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 697 | 30 | 0 | 1 | 15.1 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(C(=O)c2ccc(C[P+](CCCCC)(CCCCC)CCCCC)cc2)cc1 | 10.1016/0960-894X(95)00035-R | ||
| 10373002 | 145089 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 697 | 30 | 0 | 1 | 15.1 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(C(=O)c2ccc(C[P+](CCCCC)(CCCCC)CCCCC)cc2)cc1 | 10.1016/0960-894X(95)00036-S | ||
| CHEMBL121565 | 145089 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 697 | 30 | 0 | 1 | 15.1 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(C(=O)c2ccc(C[P+](CCCCC)(CCCCC)CCCCC)cc2)cc1 | 10.1016/0960-894X(95)00036-S | ||
| CHEMBL377100 | 145089 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 697 | 30 | 0 | 1 | 15.1 | CCCCC[P+](CCCCC)(CCCCC)Cc1ccc(C(=O)c2ccc(C[P+](CCCCC)(CCCCC)CCCCC)cc2)cc1 | 10.1016/0960-894X(95)00036-S | ||
| 44355257 | 173241 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1162 | 31 | 16 | 17 | -7.6 | NC(N)=NCCC[C@H](NC(=O)CN1CCCC[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1=O)C(=O)O | 10.1021/jm9901531 | ||
| CHEMBL427805 | 173241 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1162 | 31 | 16 | 17 | -7.6 | NC(N)=NCCC[C@H](NC(=O)CN1CCCC[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C1=O)C(=O)O | 10.1021/jm9901531 | ||
| 5312119 | 7505 | 4 | None | -1148 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 682 | 15 | 4 | 9 | 2.9 | CN(CCN(C)C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])NNC(=S)NC(c1ccccc1)c1ccccc1 | 10.1021/jm0111088 | ||
| 680 | 7505 | 4 | None | -1148 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 682 | 15 | 4 | 9 | 2.9 | CN(CCN(C)C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])NNC(=S)NC(c1ccccc1)c1ccccc1 | 10.1021/jm0111088 | ||
| CHEMBL308468 | 7505 | 4 | None | -1148 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 682 | 15 | 4 | 9 | 2.9 | CN(CCN(C)C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])NNC(=S)NC(c1ccccc1)c1ccccc1 | 10.1021/jm0111088 | ||
| 11650783 | 59203 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 706 | 14 | 3 | 8 | 5.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4ccc(S(C)(=O)=O)cc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL159066 | 59203 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 706 | 14 | 3 | 8 | 5.2 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4ccc(S(C)(=O)=O)cc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11636119 | 84853 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 564 | 8 | 3 | 6 | 4.4 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NC4CCNCC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL210100 | 84853 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 564 | 8 | 3 | 6 | 4.4 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NC4CCNCC4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11686399 | 146915 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 644 | 13 | 4 | 7 | 5.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4ccc(O)cc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL380206 | 146915 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 644 | 13 | 4 | 7 | 5.5 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4ccc(O)cc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL5285641 | 201085 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1032 | 25 | 14 | 13 | -4.2 | N=C(N)NCCC[C@H](NC(=O)CN1Cc2ccccc2CC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCNC(=N)N)C1=O)C(=O)O | 10.1021/acs.jmedchem.6b01029 | ||
| 11527892 | 146306 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 662 | 13 | 3 | 6 | 6.4 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4ccc(Cl)cc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL379541 | 146306 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 662 | 13 | 3 | 6 | 6.4 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)NCCCNCc4ccc(Cl)cc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 11671905 | 84534 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 539 | 10 | 2 | 6 | 4.2 | COCCNC(=O)C(C)(C)NS(=O)(=O)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1Cl | 10.1021/jm060137l | ||
| CHEMBL209068 | 84534 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 539 | 10 | 2 | 6 | 4.2 | COCCNC(=O)C(C)(C)NS(=O)(=O)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1Cl | 10.1021/jm060137l | ||
| 11513104 | 84943 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 557 | 8 | 2 | 5 | 6.1 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)Nc4ccccc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| CHEMBL210427 | 84943 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 557 | 8 | 2 | 5 | 6.1 | Cc1ccc2cccc(OCc3c(Cl)ccc(S(=O)(=O)NC(C)(C)C(=O)Nc4ccccc4)c3Cl)c2n1 | 10.1021/jm060137l | ||
| 10895913 | 16641 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 465 | 7 | 2 | 5 | 3.9 | CCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1C#N | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL114180 | 16641 | 0 | None | - | 1 | Guinea pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 465 | 7 | 2 | 5 | 3.9 | CCNC(=O)NCC(=O)N(C)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1C#N | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL3038102 | 217714 | 0 | None | 5 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N(CC(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)Cc1ccccc1 | 10.1021/jm950716i | ||||
| 44347466 | 21108 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 836 | 20 | 3 | 3 | 11.4 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)C2Cc3ccccc3CN2C(=O)[C@H](CCc2ccccc2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00037-T | ||
| CHEMBL1162799 | 21108 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 836 | 20 | 3 | 3 | 11.4 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)C2Cc3ccccc3CN2C(=O)[C@H](CCc2ccccc2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00037-T | ||
| CHEMBL1200034 | 21108 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 836 | 20 | 3 | 3 | 11.4 | CCCC[PH](CCCC)(CCCC)Cc1ccc(NC(=O)C2Cc3ccccc3CN2C(=O)[C@H](CCc2ccccc2)N/C(=N/C2CCCCC2)NC2CCCCC2)cc1 | 10.1016/0960-894X(95)00037-T | ||
| 44347757 | 18219 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 728 | 18 | 2 | 4 | 10.0 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)C2Cc3ccccc3CN2C(=O)C(CCc2ccccc2)NC(=O)OC(C)(C)C)cc1 | 10.1016/0960-894X(95)00037-T | ||
| CHEMBL1180347 | 18219 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 728 | 18 | 2 | 4 | 10.0 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)C2Cc3ccccc3CN2C(=O)C(CCc2ccccc2)NC(=O)OC(C)(C)C)cc1 | 10.1016/0960-894X(95)00037-T | ||
| CHEMBL123124 | 18219 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 728 | 18 | 2 | 4 | 10.0 | CCCC[P+](CCCC)(CCCC)Cc1ccc(NC(=O)C2Cc3ccccc3CN2C(=O)C(CCc2ccccc2)NC(=O)OC(C)(C)C)cc1 | 10.1016/0960-894X(95)00037-T | ||
| CHEMBL2370041 | 216553 | 0 | None | - | 1 | Guinea pig | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | None | None | None | CC(NC(=O)[C@@H]1C[C@H](O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O | 10.1021/jm00069a016 | ||||
| 44346449 | 17025 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 619 | 9 | 2 | 3 | 7.1 | O=C([C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1)N(Cc1ccccc1)C1CN2CCC1CC2 | 10.1016/0960-894X(95)00035-R | ||
| CHEMBL1160978 | 17025 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 619 | 9 | 2 | 3 | 7.1 | O=C([C@H](Cc1ccc2ccccc2c1)N/C(=N/C1CCCCC1)NC1CCCCC1)N(Cc1ccccc1)C1CN2CCC1CC2 | 10.1016/0960-894X(95)00035-R | ||
| 118719116 | 122222 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 1285 | 32 | 16 | 18 | -5.8 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@H](CCCN=C(N)N)C(=O)O)C1=O | 10.1021/jm9901531 | ||
| CHEMBL3350763 | 122222 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 1285 | 32 | 16 | 18 | -5.8 | NC(N)=NCCC[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@H](CCCN=C(N)N)C(=O)O)C1=O | 10.1021/jm9901531 | ||
| 44276841 | 102304 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 628 | 9 | 1 | 6 | 7.2 | CC(=O)Nc1ccccc1C(=O)c1ccc(CC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)n1C | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL25748 | 102304 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 628 | 9 | 1 | 6 | 7.2 | CC(=O)Nc1ccccc1C(=O)c1ccc(CC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)n1C | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL5274916 | 200608 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1405 | 31 | 20 | 19 | -4.2 | N=C(N)NCCC[C@@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@H]1CSSC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/acs.jmedchem.6b01029 | ||
| 10005078 | 40541 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 473 | 6 | 3 | 3 | 5.0 | N=C(N)Nc1cccc(CN2C(=O)C(Cc3ccccc3)N=C(c3ccccc3)c3ccccc32)c1 | 10.1016/s0960-894x(99)00015-3 | ||
| CHEMBL142260 | 40541 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 473 | 6 | 3 | 3 | 5.0 | N=C(N)Nc1cccc(CN2C(=O)C(Cc3ccccc3)N=C(c3ccccc3)c3ccccc32)c1 | 10.1016/s0960-894x(99)00015-3 | ||
| 15388870 | 117410 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 543 | 8 | 1 | 6 | 6.4 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)OCc4ccccc4)c3Cl)cccc2s1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL325742 | 117410 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 543 | 8 | 1 | 6 | 6.4 | Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)OCc4ccccc4)c3Cl)cccc2s1 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL3085458 | 217767 | 6 | None | -398 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | None | None | None | NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O)C1Cc2ccccc2C1 | 10.1021/jm990962k | ||||
| CHEMBL3085458 | 217767 | 6 | None | -398 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | None | None | None | NCCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]1CSc2ccccc2N(CC(=O)O)C1=O)C1Cc2ccccc2C1 | 10.1021/jm990961s | ||||
| 44341060 | 16332 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 539 | 10 | 1 | 6 | 5.2 | COc1ccc(N(C)C(=O)CNC(=O)/C=C/c2cccc(C)c2)c(OC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| CHEMBL112360 | 16332 | 0 | None | - | 1 | Guinea pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 539 | 10 | 1 | 6 | 5.2 | COc1ccc(N(C)C(=O)CNC(=O)/C=C/c2cccc(C)c2)c(OC)c1COc1cccc2ccc(C)nc12 | 10.1016/s0960-894x(98)00736-7 | ||
| 122189902 | 130201 | 0 | None | -13489 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 1304 | 30 | 18 | 17 | -4.4 | N=C(N)NCCC[C@H](NC(=O)C1CC2CCCCC2N1C(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](CO)NC(=O)C(Cc1cccs1)NC(=O)CNC(=O)C1CC(O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCNC(=N)N)C(=O)O | 10.1016/j.bmcl.2015.08.014 | ||
| CHEMBL3616944 | 130201 | 0 | None | -13489 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 1304 | 30 | 18 | 17 | -4.4 | N=C(N)NCCC[C@H](NC(=O)C1CC2CCCCC2N1C(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](CO)NC(=O)C(Cc1cccs1)NC(=O)CNC(=O)C1CC(O)CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCNC(=N)N)C(=O)O | 10.1016/j.bmcl.2015.08.014 | ||
| 44276667 | 105394 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 601 | 9 | 0 | 6 | 7.2 | COc1ccc(C(=O)c2ccc(CC(=O)N(C)c3ccc(Cl)c(COc4cccc5ccc(C)nc45)c3Cl)n2C)cc1 | 10.1016/s0960-894x(03)00104-5 | ||
| CHEMBL27702 | 105394 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 601 | 9 | 0 | 6 | 7.2 | COc1ccc(C(=O)c2ccc(CC(=O)N(C)c3ccc(Cl)c(COc4cccc5ccc(C)nc45)c3Cl)n2C)cc1 | 10.1016/s0960-894x(03)00104-5 | ||
| 44361937 | 176183 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 459 | 5 | 3 | 3 | 5.1 | N=C(N)Nc1ccc(N2C(=O)C(Cc3ccccc3)N=C(c3ccccc3)c3ccccc32)cc1 | 10.1016/s0960-894x(99)00015-3 | ||
| CHEMBL442294 | 176183 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 459 | 5 | 3 | 3 | 5.1 | N=C(N)Nc1ccc(N2C(=O)C(Cc3ccccc3)N=C(c3ccccc3)c3ccccc32)cc1 | 10.1016/s0960-894x(99)00015-3 | ||
| 10996140 | 74450 | 0 | None | -309 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 710 | 17 | 4 | 9 | 4.1 | CN(C)CCCN(C)CCCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(N/N=C(\S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| CHEMBL1907652 | 74450 | 0 | None | -309 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 710 | 17 | 4 | 9 | 4.1 | CN(C)CCCN(C)CCCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(N/N=C(\S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 | 10.1021/jm0111088 | ||
| 3812 | 7504 | 42 | None | -1 | 6 | Mouse | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 9333122 | ||||
| 439201 | 7504 | 42 | None | -1 | 6 | Mouse | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 9333122 | ||||
| 649 | 7504 | 42 | None | -1 | 6 | Mouse | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 9333122 | ||||
| CHEMBL406291 | 7504 | 42 | None | -1 | 6 | Mouse | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 9333122 | ||||
| DB12126 | 7504 | 42 | None | -1 | 6 | Mouse | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 9333122 | ||||
| 122173054 | 224513 | 0 | None | -1 | 6 | Rat | 8.0 | pKi | = | 8 | Binding | Drug Central | 1304 | 30 | 18 | 17 | -4.4 | N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CS1)C(=O)N[C@@H](CO)C(=O)N1CC2=C(C[C@@H]1C(=O)N1[C@H]3CCCC[C@H]3C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C=CC=C2 | None | ||
| 122173054 | 224513 | 0 | None | -1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 1304 | 30 | 18 | 17 | -4.4 | N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CS1)C(=O)N[C@@H](CO)C(=O)N1CC2=C(C[C@@H]1C(=O)N1[C@H]3CCCC[C@H]3C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C=CC=C2 | None | ||
| 3075702 | 224111 | 0 | 3H-NPC 17731 | -2 | 37 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 198 | 3 | 1 | 3 | 1.5 | C1CNC1COC2=CN=C(C=C2)Cl | None | ||
| 243 | 9976 | 91 | 3H-BRADYKININ | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| 3052762 | 9976 | 91 | 3H-BRADYKININ | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| 3502 | 9976 | 91 | 3H-BRADYKININ | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| CHEMBL117287 | 9976 | 91 | 3H-BRADYKININ | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| DB06480 | 9976 | 91 | 3H-BRADYKININ | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | ||
| 44208932 | 147485 | 7 | UNDEFINED | -89125 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 475 | 5 | 1 | 3 | 6.8 | Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 | None | ||
| CHEMBL381689 | 147485 | 7 | UNDEFINED | -89125 | 37 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 475 | 5 | 1 | 3 | 6.8 | Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 | None | ||
| 1973 | 210262 | 15 | 3H-NPC 17731 | -3 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | ||
| CHEMBL1394464 | 210262 | 15 | 3H-NPC 17731 | -3 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | ||
| CHEMBL66089 | 210262 | 15 | 3H-NPC 17731 | -3 | 36 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 462 | 3 | 1 | 7 | 3.9 | Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 | None | ||
| None | 223272 | 0 | 3H-BRADYKININ | -10471285 | 17 | Rat | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 372 | 2 | 1 | 3 | 4.4 | CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl | None | ||
| 1016 | 10519 | 78 | None | -46 | 35 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | None | ||
| 2561 | 10519 | 78 | None | -46 | 35 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | None | ||
| 2733526 | 10519 | 78 | None | -46 | 35 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | None | ||
| 5384 | 10519 | 78 | None | -46 | 35 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | None | ||
| CHEMBL83 | 10519 | 78 | None | -46 | 35 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | None | ||
| DB00675 | 10519 | 78 | None | -46 | 35 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 371 | 8 | 0 | 2 | 6.0 | CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 | None | ||
| 176 | 7186 | 66 | None | -5 | 31 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | ||
| 2157 | 7186 | 66 | None | -5 | 31 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | ||
| 2566 | 7186 | 66 | None | -5 | 31 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | ||
| CHEMBL633 | 7186 | 66 | None | -5 | 31 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | ||
| DB01118 | 7186 | 66 | None | -5 | 31 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 645 | 11 | 0 | 4 | 6.9 | CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 | None | ||
| 122173054 | 224513 | 0 | None | -1 | 6 | Mouse | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 1304 | 30 | 18 | 17 | -4.4 | N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CS1)C(=O)N[C@@H](CO)C(=O)N1CC2=C(C[C@@H]1C(=O)N1[C@H]3CCCC[C@H]3C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C=CC=C2 | None | ||
| 122173054 | 224513 | 0 | None | -1 | 6 | Guinea pig | 8.0 | pKi | = | 8 | Binding | Drug Central | 1304 | 30 | 18 | 17 | -4.4 | N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CS1)C(=O)N[C@@H](CO)C(=O)N1CC2=C(C[C@@H]1C(=O)N1[C@H]3CCCC[C@H]3C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C=CC=C2 | None | ||
| 12421 | 8181 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | 534 | 9 | 1 | 7 | 5.1 | [2H][C@](C)(C1=C(C(=CC(=C1)F)Cl)COC=2C=CC=C3C(=CC(=NC23)C)C4=NC=NN4C)NC(COC(F)F)=O | 32636746 | ||
| 12421 | 8181 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | 534 | 9 | 1 | 7 | 5.1 | [2H][C@](C)(C1=C(C(=CC(=C1)F)Cl)COC=2C=CC=C3C(=CC(=NC23)C)C4=NC=NN4C)NC(COC(F)F)=O | 35086057 | ||
| 154623230 | 8181 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | 534 | 9 | 1 | 7 | 5.1 | [2H][C@](C)(C1=C(C(=CC(=C1)F)Cl)COC=2C=CC=C3C(=CC(=NC23)C)C4=NC=NN4C)NC(COC(F)F)=O | 32636746 | ||
| 154623230 | 8181 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | 534 | 9 | 1 | 7 | 5.1 | [2H][C@](C)(C1=C(C(=CC(=C1)F)Cl)COC=2C=CC=C3C(=CC(=NC23)C)C4=NC=NN4C)NC(COC(F)F)=O | 35086057 | ||
| 11159 | 7878 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | 533 | 9 | 1 | 7 | 5.1 | FC(OCC(=O)N[C@H](c1cc(F)cc(c1COc1cccc2c1nc(C)cc2c1ncnn1C)Cl)C)F | 32636746 | ||
| 138634054 | 7878 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | 533 | 9 | 1 | 7 | 5.1 | FC(OCC(=O)N[C@H](c1cc(F)cc(c1COc1cccc2c1nc(C)cc2c1ncnn1C)Cl)C)F | 32636746 | ||
| 667 | 8754 | 37 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 10514288 | ||||
| 6918173 | 8754 | 37 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 10514288 | ||||
| 71364 | 8754 | 37 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 10514288 | ||||
| CHEMBL2028850 | 8754 | 37 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 10514288 | ||||
| DB06196 | 8754 | 37 | None | -1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 10514288 | ||||
| 679 | 7202 | 0 | None | 2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 710 | 12 | 4 | 7 | 5.1 | Cc1cc(C)c2c(n1)c(ccc2)OCc1c(Cl)ccc(c1Cl)S(=O)(=O)N1CCC[C@H]1C(=O)NCCCNC(=O)c1ccc(cc1)C(=N)N | 10596852 | ||
| 9831652 | 7202 | 0 | None | 2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 710 | 12 | 4 | 7 | 5.1 | Cc1cc(C)c2c(n1)c(ccc2)OCc1c(Cl)ccc(c1Cl)S(=O)(=O)N1CCC[C@H]1C(=O)NCCCNC(=O)c1ccc(cc1)C(=N)N | 10596852 | ||
| CHEMBL2107725 | 7202 | 0 | None | 2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 710 | 12 | 4 | 7 | 5.1 | Cc1cc(C)c2c(n1)c(ccc2)OCc1c(Cl)ccc(c1Cl)S(=O)(=O)N1CCC[C@H]1C(=O)NCCCNC(=O)c1ccc(cc1)C(=N)N | 10596852 | ||
| DB05038 | 7202 | 0 | None | 2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 710 | 12 | 4 | 7 | 5.1 | Cc1cc(C)c2c(n1)c(ccc2)OCc1c(Cl)ccc(c1Cl)S(=O)(=O)N1CCC[C@H]1C(=O)NCCCNC(=O)c1ccc(cc1)C(=N)N | 10596852 | ||
| 670 | 8901 | 0 | None | 8 | 2 | Rat | 10.1 | pKi | None | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 10514288 | ||||
| 667 | 8754 | 37 | None | -1 | 6 | Rat | 10.2 | pKi | None | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 10694205 | ||||
| 6918173 | 8754 | 37 | None | -1 | 6 | Rat | 10.2 | pKi | None | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 10694205 | ||||
| 71364 | 8754 | 37 | None | -1 | 6 | Rat | 10.2 | pKi | None | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 10694205 | ||||
| CHEMBL2028850 | 8754 | 37 | None | -1 | 6 | Rat | 10.2 | pKi | None | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 10694205 | ||||
| DB06196 | 8754 | 37 | None | -1 | 6 | Rat | 10.2 | pKi | None | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 10694205 | ||||
| 5312119 | 7505 | 4 | None | -1148 | 2 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 682 | 15 | 4 | 9 | 2.9 | CN(CCN(C)C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])NNC(=S)NC(c1ccccc1)c1ccccc1 | 10694205 | ||
| 680 | 7505 | 4 | None | -1148 | 2 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 682 | 15 | 4 | 9 | 2.9 | CN(CCN(C)C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])NNC(=S)NC(c1ccccc1)c1ccccc1 | 10694205 | ||
| CHEMBL308468 | 7505 | 4 | None | -1148 | 2 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 682 | 15 | 4 | 9 | 2.9 | CN(CCN(C)C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])NNC(=S)NC(c1ccccc1)c1ccccc1 | 10694205 | ||
| 658 | 9647 | 0 | None | -3981 | 2 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | None | None | None | None | 8995263 | ||||
| 132927 | 10856 | 4 | None | 6 | 2 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 8197121 | ||
| 132927 | 10856 | 4 | None | 6 | 2 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 8394936 | ||
| 138398059 | 10856 | 4 | None | 6 | 2 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 8197121 | ||
| 138398059 | 10856 | 4 | None | 6 | 2 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 8394936 | ||
| 677 | 10856 | 4 | None | 6 | 2 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 8197121 | ||
| 677 | 10856 | 4 | None | 6 | 2 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 8394936 | ||
| CHEMBL294453 | 10856 | 4 | None | 6 | 2 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 8197121 | ||
| CHEMBL294453 | 10856 | 4 | None | 6 | 2 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 8394936 | ||
| CHEMBL551291 | 10856 | 4 | None | 6 | 2 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 8197121 | ||
| CHEMBL551291 | 10856 | 4 | None | 6 | 2 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 746 | 18 | 3 | 2 | 8.5 | CCCC[P+](Cc1ccc(cc1)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)NC(=NC1CCCCC1)NC1CCCCC1)(CCCC)CCCC.[Cl-] | 8394936 | ||
| 5311114 | 8469 | 8 | None | - | 1 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 697 | 12 | 2 | 7 | 6.6 | CNC(=O)c1ccc(cc1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2OCc1ccccn1)Cl)C | 9224807 | ||
| 668 | 8469 | 8 | None | - | 1 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 697 | 12 | 2 | 7 | 6.6 | CNC(=O)c1ccc(cc1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2OCc1ccccn1)Cl)C | 9224807 | ||
| CHEMBL99869 | 8469 | 8 | None | - | 1 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 697 | 12 | 2 | 7 | 6.6 | CNC(=O)c1ccc(cc1)/C=C/C(=O)NCC(=O)N(c1ccc(c(c1Cl)COc1cccc2c1nc(C)cc2OCc1ccccn1)Cl)C | 9224807 | ||
| 679 | 7202 | 0 | None | -2 | 2 | Rat | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 710 | 12 | 4 | 7 | 5.1 | Cc1cc(C)c2c(n1)c(ccc2)OCc1c(Cl)ccc(c1Cl)S(=O)(=O)N1CCC[C@H]1C(=O)NCCCNC(=O)c1ccc(cc1)C(=N)N | 10596852 | ||
| 9831652 | 7202 | 0 | None | -2 | 2 | Rat | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 710 | 12 | 4 | 7 | 5.1 | Cc1cc(C)c2c(n1)c(ccc2)OCc1c(Cl)ccc(c1Cl)S(=O)(=O)N1CCC[C@H]1C(=O)NCCCNC(=O)c1ccc(cc1)C(=N)N | 10596852 | ||
| CHEMBL2107725 | 7202 | 0 | None | -2 | 2 | Rat | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 710 | 12 | 4 | 7 | 5.1 | Cc1cc(C)c2c(n1)c(ccc2)OCc1c(Cl)ccc(c1Cl)S(=O)(=O)N1CCC[C@H]1C(=O)NCCCNC(=O)c1ccc(cc1)C(=N)N | 10596852 | ||
| DB05038 | 7202 | 0 | None | -2 | 2 | Rat | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 710 | 12 | 4 | 7 | 5.1 | Cc1cc(C)c2c(n1)c(ccc2)OCc1c(Cl)ccc(c1Cl)S(=O)(=O)N1CCC[C@H]1C(=O)NCCCNC(=O)c1ccc(cc1)C(=N)N | 10596852 | ||
| 672 | 9047 | 21 | None | 1 | 2 | Rat | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | None | None | None | None | 10514288 | ||||
| 672 | 9047 | 21 | None | 1 | 2 | Rat | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | None | None | None | None | 7965719 | ||||
| 6918284 | 9047 | 21 | None | 1 | 2 | Rat | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | None | None | None | None | 10514288 | ||||
| 6918284 | 9047 | 21 | None | 1 | 2 | Rat | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | None | None | None | None | 7965719 | ||||
| CHEMBL2105864 | 9047 | 21 | None | 1 | 2 | Rat | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | None | None | None | None | 10514288 | ||||
| CHEMBL2105864 | 9047 | 21 | None | 1 | 2 | Rat | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | None | None | None | None | 7965719 | ||||
| DB06549 | 9047 | 21 | None | 1 | 2 | Rat | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | None | None | None | None | 10514288 | ||||
| DB06549 | 9047 | 21 | None | 1 | 2 | Rat | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | None | None | None | None | 7965719 | ||||
| 3081308 | 9646 | 0 | None | 15 | 2 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 8995263 | ||||
| 657 | 9646 | 0 | None | 15 | 2 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 8995263 | ||||
| 44316620 | 8902 | 0 | None | 19 | 2 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | None | None | None | None | 10882364 | ||||
| 656 | 8902 | 0 | None | 19 | 2 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | None | None | None | None | 10882364 | ||||
| CHEMBL408846 | 8902 | 0 | None | 19 | 2 | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | None | None | None | None | 10882364 | ||||
| 653 | 7353 | 0 | None | -1 | 4 | Mouse | 9.0 | pKi | None | 9 | Binding | Guide to Pharmacology | None | None | None | None | 9276157 | ||||
| 653 | 7353 | 0 | None | 1 | 4 | Human | 9.1 | pKi | None | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8856115 | ||||
| 653 | 7353 | 0 | None | 1 | 4 | Human | 9.1 | pKi | None | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 9276157 | ||||
| 670 | 8901 | 0 | None | -8 | 2 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | None | None | None | None | 10514288 | ||||
| 5312119 | 7505 | 4 | None | 1148 | 2 | Rat | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 682 | 15 | 4 | 9 | 2.9 | CN(CCN(C)C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])NNC(=S)NC(c1ccccc1)c1ccccc1 | 10694205 | ||
| 680 | 7505 | 4 | None | 1148 | 2 | Rat | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 682 | 15 | 4 | 9 | 2.9 | CN(CCN(C)C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])NNC(=S)NC(c1ccccc1)c1ccccc1 | 10694205 | ||
| CHEMBL308468 | 7505 | 4 | None | 1148 | 2 | Rat | 9.4 | pKi | None | 9.4 | Binding | Guide to Pharmacology | 682 | 15 | 4 | 9 | 2.9 | CN(CCN(C)C)CCNC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])NNC(=S)NC(c1ccccc1)c1ccccc1 | 10694205 | ||
| 667 | 8754 | 37 | None | -2 | 6 | Mouse | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 6918173 | 8754 | 37 | None | -2 | 6 | Mouse | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| 71364 | 8754 | 37 | None | -2 | 6 | Mouse | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| CHEMBL2028850 | 8754 | 37 | None | -2 | 6 | Mouse | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 8302267 | ||||
| DB06196 | 8754 | 37 | None | -2 | 6 | Mouse | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 8302267 | ||||