Ligand source activities (1 row/activity)
Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
156013177 | 184236 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 559 | 7 | 1 | 7 | 5.4 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Br)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4638895 | 184236 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 559 | 7 | 1 | 7 | 5.4 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Br)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156011084 | 183874 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4633217 | 183874 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156021011 | 184830 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4647206 | 184830 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
71768224 | 184745 | 21 | None | 39 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4645971 | 184745 | 21 | None | 39 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156015010 | 184329 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4640319 | 184329 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156012910 | 184225 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4638791 | 184225 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156019927 | 184728 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 441 | 6 | 2 | 4 | 4.1 | COc1cccc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4645725 | 184728 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 441 | 6 | 2 | 4 | 4.1 | COc1cccc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2019.126899 | ||
156019169 | 184786 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4646463 | 184786 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | ||
156016038 | 184406 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cccc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4641144 | 184406 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cccc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156013415 | 184252 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 495 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(C)ccc2C)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4639114 | 184252 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 495 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(C)ccc2C)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156020735 | 184895 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 481 | 8 | 2 | 6 | 3.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4648121 | 184895 | 0 | None | - | 1 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 481 | 8 | 2 | 6 | 3.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156021922 | 184970 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)c(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4649351 | 184970 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)c(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156010556 | 183813 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 499 | 7 | 1 | 7 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4632425 | 183813 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 499 | 7 | 1 | 7 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156010734 | 183867 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 480 | 7 | 1 | 6 | 5.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4633183 | 183867 | 0 | None | - | 1 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 480 | 7 | 1 | 6 | 5.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
25303824 | 184904 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 467 | 8 | 2 | 6 | 3.5 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4648327 | 184904 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 467 | 8 | 2 | 6 | 3.5 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156016810 | 184530 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 485 | 8 | 2 | 6 | 3.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(F)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4642662 | 184530 | 0 | None | - | 1 | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 485 | 8 | 2 | 6 | 3.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(F)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156016430 | 184451 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4641681 | 184451 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156019204 | 184733 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 545 | 8 | 2 | 6 | 4.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Br)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4645763 | 184733 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 545 | 8 | 2 | 6 | 4.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Br)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156018695 | 184647 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4644405 | 184647 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156016371 | 184419 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 475 | 7 | 1 | 6 | 4.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3n2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4641301 | 184419 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 475 | 7 | 1 | 6 | 4.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3n2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
25303824 | 184175 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 467 | 8 | 2 | 6 | 3.5 | COc1cc(C(=O)N[C@@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4638193 | 184175 | 0 | None | - | 1 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 467 | 8 | 2 | 6 | 3.5 | COc1cc(C(=O)N[C@@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156020287 | 184864 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4647701 | 184864 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156014652 | 184013 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4635707 | 184013 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156012554 | 184125 | 0 | None | - | 1 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 474 | 7 | 1 | 5 | 5.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4637473 | 184125 | 0 | None | - | 1 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 474 | 7 | 1 | 5 | 5.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156012971 | 184292 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 495 | 7 | 1 | 7 | 4.9 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4639692 | 184292 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 495 | 7 | 1 | 7 | 4.9 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156012542 | 184103 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 549 | 7 | 1 | 7 | 5.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4637126 | 184103 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 549 | 7 | 1 | 7 | 5.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156014926 | 184326 | 0 | None | - | 1 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1cccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)c1 | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4640301 | 184326 | 0 | None | - | 1 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1cccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)c1 | 10.1016/j.bmcl.2019.126899 | ||
156017591 | 184621 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 455 | 5 | 2 | 5 | 3.8 | O=C(CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1ccc3c(c1)OCO3)C2)Nc1ccc(Cl)cc1 | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4644085 | 184621 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 455 | 5 | 2 | 5 | 3.8 | O=C(CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1ccc3c(c1)OCO3)C2)Nc1ccc(Cl)cc1 | 10.1016/j.bmcl.2019.126899 | ||
156019124 | 184709 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 441 | 6 | 2 | 4 | 4.1 | COc1ccc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4645432 | 184709 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 441 | 6 | 2 | 4 | 4.1 | COc1ccc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc1 | 10.1016/j.bmcl.2019.126899 | ||
156018089 | 184628 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 485 | 8 | 2 | 6 | 3.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2F)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4644133 | 184628 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 485 | 8 | 2 | 6 | 3.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2F)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156018738 | 184705 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 539 | 10 | 2 | 8 | 3.6 | CCOC(=O)c1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4645361 | 184705 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 539 | 10 | 2 | 8 | 3.6 | CCOC(=O)c1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | ||
156019654 | 184792 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)ccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4646569 | 184792 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)ccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156010068 | 183850 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 492 | 8 | 2 | 7 | 3.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C#N)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4632989 | 183850 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 492 | 8 | 2 | 7 | 3.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C#N)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156015077 | 184306 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 535 | 8 | 2 | 6 | 4.5 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C(F)(F)F)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4639996 | 184306 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 535 | 8 | 2 | 6 | 4.5 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C(F)(F)F)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156017102 | 184491 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 481 | 7 | 1 | 7 | 4.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4642230 | 184491 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 481 | 7 | 1 | 7 | 4.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156015991 | 184311 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 485 | 8 | 2 | 6 | 3.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(F)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4640101 | 184311 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 485 | 8 | 2 | 6 | 3.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(F)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156012383 | 184196 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cccc(Cl)c3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4638493 | 184196 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cccc(Cl)c3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156015439 | 184335 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 545 | 8 | 2 | 6 | 4.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Br)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4640388 | 184335 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 545 | 8 | 2 | 6 | 4.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Br)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156019227 | 184763 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Cl)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4646120 | 184763 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Cl)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156020329 | 184936 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4648997 | 184936 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156014947 | 184367 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 481 | 8 | 2 | 6 | 3.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4640657 | 184367 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 481 | 8 | 2 | 6 | 3.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 |
Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
71525976 | 160268 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 453 | 7 | 3 | 8 | 3.1 | Cc1ccc(C(Nc2c(Nc3cccc(C(=O)N(C)C)c3O)c(=O)c2=O)C2(C)CCCO2)o1 | 10.1021/acs.jmedchem.5b01337 | ||
CHEMBL3979652 | 160268 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 453 | 7 | 3 | 8 | 3.1 | Cc1ccc(C(Nc2c(Nc3cccc(C(=O)N(C)C)c3O)c(=O)c2=O)C2(C)CCCO2)o1 | 10.1021/acs.jmedchem.5b01337 | ||
156019475 | 184758 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 464 | 7 | 2 | 6 | 3.9 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3[nH]2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4646034 | 184758 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 464 | 7 | 2 | 6 | 3.9 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3[nH]2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156010556 | 183813 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 499 | 7 | 1 | 7 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4632425 | 183813 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 499 | 7 | 1 | 7 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156020287 | 184864 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4647701 | 184864 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156020779 | 184959 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 509 | 8 | 1 | 8 | 4.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)c2nc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4649243 | 184959 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 509 | 8 | 1 | 8 | 4.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)c2nc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156019227 | 184763 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Cl)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4646120 | 184763 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Cl)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156019654 | 184792 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)ccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4646569 | 184792 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)ccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
71768224 | 184745 | 21 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4645971 | 184745 | 21 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156012910 | 184225 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4638791 | 184225 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156015439 | 184335 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 545 | 8 | 2 | 6 | 4.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Br)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4640388 | 184335 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 545 | 8 | 2 | 6 | 4.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Br)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156020329 | 184936 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4648997 | 184936 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156018738 | 184705 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 539 | 10 | 2 | 8 | 3.6 | CCOC(=O)c1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4645361 | 184705 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 539 | 10 | 2 | 8 | 3.6 | CCOC(=O)c1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | ||
156016430 | 184451 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4641681 | 184451 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156020735 | 184895 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 481 | 8 | 2 | 6 | 3.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4648121 | 184895 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 481 | 8 | 2 | 6 | 3.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
71768224 | 184745 | 21 | None | - | 0 | Mouse | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4645971 | 184745 | 21 | None | - | 0 | Mouse | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
71768225 | 184642 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1ccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)cc1 | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4644339 | 184642 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1ccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)cc1 | 10.1016/j.bmcl.2019.126899 | ||
156019169 | 184786 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4646463 | 184786 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | ||
156012542 | 184103 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 549 | 7 | 1 | 7 | 5.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4637126 | 184103 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 549 | 7 | 1 | 7 | 5.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156014218 | 184022 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 463 | 7 | 2 | 5 | 4.5 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3[nH]2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4635792 | 184022 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 463 | 7 | 2 | 5 | 4.5 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3[nH]2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156018695 | 184647 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4644405 | 184647 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156012971 | 184292 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 495 | 7 | 1 | 7 | 4.9 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4639692 | 184292 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 495 | 7 | 1 | 7 | 4.9 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156012383 | 184196 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cccc(Cl)c3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4638493 | 184196 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cccc(Cl)c3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156015010 | 184329 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4640319 | 184329 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156017102 | 184491 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 481 | 7 | 1 | 7 | 4.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4642230 | 184491 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 481 | 7 | 1 | 7 | 4.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156021011 | 184830 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4647206 | 184830 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156013810 | 184062 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 511 | 8 | 1 | 8 | 4.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(OC)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4636339 | 184062 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 511 | 8 | 1 | 8 | 4.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(OC)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156012554 | 184125 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 474 | 7 | 1 | 5 | 5.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4637473 | 184125 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 474 | 7 | 1 | 5 | 5.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156019204 | 184733 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 545 | 8 | 2 | 6 | 4.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Br)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4645763 | 184733 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 545 | 8 | 2 | 6 | 4.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Br)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156021922 | 184970 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)c(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4649351 | 184970 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)c(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156013800 | 184057 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2c(Cl)cccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4636310 | 184057 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2c(Cl)cccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156012542 | 184103 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 549 | 7 | 1 | 7 | 5.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4637126 | 184103 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 549 | 7 | 1 | 7 | 5.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156012542 | 184103 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 549 | 7 | 1 | 7 | 5.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4637126 | 184103 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 549 | 7 | 1 | 7 | 5.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156014652 | 184013 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4635707 | 184013 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156014926 | 184326 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1cccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)c1 | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4640301 | 184326 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1cccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)c1 | 10.1016/j.bmcl.2019.126899 | ||
156016810 | 184530 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 485 | 8 | 2 | 6 | 3.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(F)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4642662 | 184530 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 485 | 8 | 2 | 6 | 3.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(F)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
25303824 | 184904 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 467 | 8 | 2 | 6 | 3.5 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4648327 | 184904 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 467 | 8 | 2 | 6 | 3.5 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156013415 | 184252 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 495 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(C)ccc2C)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4639114 | 184252 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 495 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(C)ccc2C)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156018089 | 184628 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 485 | 8 | 2 | 6 | 3.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2F)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4644133 | 184628 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 485 | 8 | 2 | 6 | 3.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2F)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156015077 | 184306 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 535 | 8 | 2 | 6 | 4.5 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C(F)(F)F)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4639996 | 184306 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 535 | 8 | 2 | 6 | 4.5 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C(F)(F)F)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156016371 | 184419 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 475 | 7 | 1 | 6 | 4.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3n2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4641301 | 184419 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 475 | 7 | 1 | 6 | 4.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3n2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156011084 | 183874 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4633217 | 183874 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156016540 | 184516 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 465 | 7 | 1 | 7 | 4.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3o2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4642449 | 184516 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 465 | 7 | 1 | 7 | 4.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3o2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156014947 | 184367 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 481 | 8 | 2 | 6 | 3.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4640657 | 184367 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 481 | 8 | 2 | 6 | 3.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156013177 | 184236 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 559 | 7 | 1 | 7 | 5.4 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Br)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4638895 | 184236 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 559 | 7 | 1 | 7 | 5.4 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Br)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156015991 | 184311 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 485 | 8 | 2 | 6 | 3.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(F)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4640101 | 184311 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 485 | 8 | 2 | 6 | 3.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(F)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156010734 | 183867 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 7 | 1 | 6 | 5.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4633183 | 183867 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 7 | 1 | 6 | 5.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156010068 | 183850 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 492 | 8 | 2 | 7 | 3.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C#N)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4632989 | 183850 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 492 | 8 | 2 | 7 | 3.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C#N)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156016038 | 184406 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cccc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4641144 | 184406 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cccc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
156021218 | 184921 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 481 | 8 | 2 | 6 | 3.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(C)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
CHEMBL4648749 | 184921 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 481 | 8 | 2 | 6 | 3.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(C)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
855 | 8034 | 0 | None | - | 1 | Human | 9.0 | pKd | = | 9 | Binding | Guide to Pharmacology | None | None | None | None | 11290797 |