Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 156013177 | 177562 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 559 | 7 | 1 | 7 | 5.4 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Br)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4638895 | 177562 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 559 | 7 | 1 | 7 | 5.4 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Br)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156011084 | 177200 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4633217 | 177200 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156021011 | 178156 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4647206 | 178156 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 71768224 | 178071 | None | 23 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 39 | 2 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4645971 | 178071 | None | 23 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 39 | 2 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156015010 | 177655 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4640319 | 177655 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156012910 | 177551 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4638791 | 177551 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156019927 | 178054 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 441 | 6 | 2 | 4 | 4.1 | COc1cccc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4645725 | 178054 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 441 | 6 | 2 | 4 | 4.1 | COc1cccc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)c1 | 10.1016/j.bmcl.2019.126899 | ||
| 156019169 | 178112 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4646463 | 178112 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | ||
| 156016038 | 177732 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cccc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4641144 | 177732 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cccc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156013415 | 177578 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 495 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(C)ccc2C)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4639114 | 177578 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 495 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(C)ccc2C)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156020735 | 178221 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 481 | 8 | 2 | 6 | 3.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4648121 | 178221 | None | 0 | Human | Functional | pIC50 | = | 4.8 | 4.8 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 481 | 8 | 2 | 6 | 3.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156021922 | 178296 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)c(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4649351 | 178296 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)c(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156010556 | 177139 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 499 | 7 | 1 | 7 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4632425 | 177139 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 499 | 7 | 1 | 7 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156010734 | 177193 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 480 | 7 | 1 | 6 | 5.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4633183 | 177193 | None | 0 | Human | Functional | pIC50 | = | 4.6 | 4.6 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 480 | 7 | 1 | 6 | 5.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 25303824 | 178230 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 467 | 8 | 2 | 6 | 3.5 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4648327 | 178230 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 467 | 8 | 2 | 6 | 3.5 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156016810 | 177856 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 485 | 8 | 2 | 6 | 3.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(F)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4642662 | 177856 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 485 | 8 | 2 | 6 | 3.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(F)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156016430 | 177777 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4641681 | 177777 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156019204 | 178059 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 545 | 8 | 2 | 6 | 4.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Br)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4645763 | 178059 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 545 | 8 | 2 | 6 | 4.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Br)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156018695 | 177973 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4644405 | 177973 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156016371 | 177745 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 475 | 7 | 1 | 6 | 4.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3n2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4641301 | 177745 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 475 | 7 | 1 | 6 | 4.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3n2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 25303824 | 177501 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 467 | 8 | 2 | 6 | 3.5 | COc1cc(C(=O)N[C@@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4638193 | 177501 | None | 0 | Human | Functional | pIC50 | = | 4.4 | 4.4 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 467 | 8 | 2 | 6 | 3.5 | COc1cc(C(=O)N[C@@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156020287 | 178190 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4647701 | 178190 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156014652 | 177339 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4635707 | 177339 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156012554 | 177451 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 474 | 7 | 1 | 5 | 5.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4637473 | 177451 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 474 | 7 | 1 | 5 | 5.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156012971 | 177618 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 495 | 7 | 1 | 7 | 4.9 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4639692 | 177618 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay |
ChEMBL | 495 | 7 | 1 | 7 | 4.9 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
Showing 1 to 50 of 82 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 71525976 | 153578 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | Antagonist activity at CXCR6 (unknown origin)Antagonist activity at CXCR6 (unknown origin) |
ChEMBL | 453 | 7 | 3 | 8 | 3.1 | Cc1ccc(C(Nc2c(Nc3cccc(C(=O)N(C)C)c3O)c(=O)c2=O)C2(C)CCCO2)o1 | 10.1021/acs.jmedchem.5b01337 | ||
| CHEMBL3979652 | 153578 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | Antagonist activity at CXCR6 (unknown origin)Antagonist activity at CXCR6 (unknown origin) |
ChEMBL | 453 | 7 | 3 | 8 | 3.1 | Cc1ccc(C(Nc2c(Nc3cccc(C(=O)N(C)C)c3O)c(=O)c2=O)C2(C)CCCO2)o1 | 10.1021/acs.jmedchem.5b01337 | ||
| 156019475 | 178084 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 464 | 7 | 2 | 6 | 3.9 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3[nH]2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4646034 | 178084 | None | 0 | Human | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 464 | 7 | 2 | 6 | 3.9 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3[nH]2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156010556 | 177139 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 499 | 7 | 1 | 7 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4632425 | 177139 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 499 | 7 | 1 | 7 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156020287 | 178190 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4647701 | 178190 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156020779 | 178285 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 509 | 8 | 1 | 8 | 4.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)c2nc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4649243 | 178285 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 509 | 8 | 1 | 8 | 4.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)c2nc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156019227 | 178089 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Cl)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4646120 | 178089 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Cl)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156019654 | 178118 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)ccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4646569 | 178118 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)ccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 71768224 | 178071 | None | 23 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4645971 | 178071 | None | 23 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156012910 | 177551 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4638791 | 177551 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156015439 | 177661 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 545 | 8 | 2 | 6 | 4.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Br)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4640388 | 177661 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 545 | 8 | 2 | 6 | 4.2 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Br)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156020329 | 178262 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4648997 | 178262 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156018738 | 178031 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 539 | 10 | 2 | 8 | 3.6 | CCOC(=O)c1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4645361 | 178031 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 539 | 10 | 2 | 8 | 3.6 | CCOC(=O)c1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | ||
| 156016430 | 177777 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4641681 | 177777 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156020735 | 178221 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 481 | 8 | 2 | 6 | 3.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4648121 | 178221 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 481 | 8 | 2 | 6 | 3.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 71768224 | 178071 | None | 23 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Antagonist activity at mouse CXCR6 by DiscoveRx cell based beta-arrestin assayAntagonist activity at mouse CXCR6 by DiscoveRx cell based beta-arrestin assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4645971 | 178071 | None | 23 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Antagonist activity at mouse CXCR6 by DiscoveRx cell based beta-arrestin assayAntagonist activity at mouse CXCR6 by DiscoveRx cell based beta-arrestin assay |
ChEMBL | 501 | 8 | 2 | 6 | 4.1 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 71768225 | 177968 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1ccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)cc1 | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4644339 | 177968 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1ccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)cc1 | 10.1016/j.bmcl.2019.126899 | ||
| 156019169 | 178112 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4646463 | 178112 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 497 | 9 | 2 | 7 | 3.5 | COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 | 10.1016/j.bmcl.2019.126899 | ||
| 156012542 | 177429 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Inhibition of CXCR6-mediated cell invasion in human SKHEP1 cells after 72 hrs by transwell assayInhibition of CXCR6-mediated cell invasion in human SKHEP1 cells after 72 hrs by transwell assay |
ChEMBL | 549 | 7 | 1 | 7 | 5.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4637126 | 177429 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Inhibition of CXCR6-mediated cell invasion in human SKHEP1 cells after 72 hrs by transwell assayInhibition of CXCR6-mediated cell invasion in human SKHEP1 cells after 72 hrs by transwell assay |
ChEMBL | 549 | 7 | 1 | 7 | 5.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156014218 | 177348 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 463 | 7 | 2 | 5 | 4.5 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3[nH]2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4635792 | 177348 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 463 | 7 | 2 | 5 | 4.5 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3[nH]2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156018695 | 177973 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4644405 | 177973 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 458 | 7 | 1 | 5 | 4.7 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156012971 | 177618 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 495 | 7 | 1 | 7 | 4.9 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4639692 | 177618 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 495 | 7 | 1 | 7 | 4.9 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156012383 | 177522 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cccc(Cl)c3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4638493 | 177522 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cccc(Cl)c3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156015010 | 177655 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4640319 | 177655 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 515 | 7 | 1 | 7 | 5.3 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156017102 | 177817 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 481 | 7 | 1 | 7 | 4.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4642230 | 177817 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 481 | 7 | 1 | 7 | 4.6 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3s2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| 156021011 | 178156 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
| CHEMBL4647206 | 178156 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay |
ChEMBL | 535 | 8 | 2 | 6 | 4.8 | COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC | 10.1016/j.bmcl.2019.126899 | ||
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