Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
10390 2088 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Measuring the inhibition of FKN-stimulated ERK1/2 phosphorylation.Measuring the inhibition of FKN-stimulated ERK1/2 phosphorylation.
Guide to Pharmacology 419 5 0 4 5.2 Clc1ccc(cc1)C1CCN(CC1)CCCn1c(=O)c2cccn2c2c1cccc2 27001765
57382073 2088 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Measuring the inhibition of FKN-stimulated ERK1/2 phosphorylation.Measuring the inhibition of FKN-stimulated ERK1/2 phosphorylation.
Guide to Pharmacology 419 5 0 4 5.2 Clc1ccc(cc1)C1CCN(CC1)CCCn1c(=O)c2cccn2c2c1cccc2 27001765
856 1244 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14607932


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
71293797 171731 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 501 8 2 4 4.6 Cc1cccc(Cl)c1CN1C[C@H](C)[C@](CC(=O)O)(C(=O)NC2CCN(CC3=CCCCC3)CC2)C1 nan
CHEMBL4475030 171731 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 501 8 2 4 4.6 Cc1cccc(Cl)c1CN1C[C@H](C)[C@](CC(=O)O)(C(=O)NC2CCN(CC3=CCCCC3)CC2)C1 nan
71293723 169486 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 539 9 2 4 5.4 C[C@H]1CN(Cc2c(Cl)cccc2C(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2CCCCC2)CC1 nan
CHEMBL4442967 169486 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 539 9 2 4 5.4 C[C@H]1CN(Cc2c(Cl)cccc2C(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2CCCCC2)CC1 nan
71293703 174375 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 549 10 2 4 5.0 CCCC(F)CN1CCC(NC(=O)[C@]2(CC(=O)O)CN(Cc3c(Cl)cccc3C(F)(F)F)C[C@@H]2C)CC1 nan
CHEMBL4565523 174375 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 549 10 2 4 5.0 CCCC(F)CN1CCC(NC(=O)[C@]2(CC(=O)O)CN(Cc3c(Cl)cccc3C(F)(F)F)C[C@@H]2C)CC1 nan
71293644 173805 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 527 12 2 4 5.4 CCCCCCN1CCC(NC(=O)[C@]2(CC(=O)O)CN(Cc3c(Cl)cccc3C(F)F)C[C@@H]2C)CC1 nan
CHEMBL4551880 173805 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 527 12 2 4 5.4 CCCCCCN1CCC(NC(=O)[C@]2(CC(=O)O)CN(Cc3c(Cl)cccc3C(F)F)C[C@@H]2C)CC1 nan
71293790 168983 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 523 9 2 4 4.9 C[C@H]1CN(Cc2c(Cl)cccc2C(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCC2)CC1 nan
CHEMBL4435586 168983 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 523 9 2 4 4.9 C[C@H]1CN(Cc2c(Cl)cccc2C(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCC2)CC1 nan
71293710 169524 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 507 8 2 4 4.6 C[C@H]1CN(Cc2c(Cl)cccc2Cl)C[C@@]1(CC(=O)O)C(=O)N[C@H]1CCN(CC2=CCCCC2)C1 nan
CHEMBL4443425 169524 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 507 8 2 4 4.6 C[C@H]1CN(Cc2c(Cl)cccc2Cl)C[C@@]1(CC(=O)O)C(=O)N[C@H]1CCN(CC2=CCCCC2)C1 nan
71293610 170435 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 559 8 2 4 5.3 C[C@H]1CN(Cc2c(Cl)cccc2Cl)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2CCC(F)(F)CC2)CC1 nan
CHEMBL4456446 170435 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 559 8 2 4 5.3 C[C@H]1CN(Cc2c(Cl)cccc2Cl)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2CCC(F)(F)CC2)CC1 nan
71293715 169799 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 487 8 2 4 4.3 Cc1cccc(Cl)c1CN1C[C@H](C)[C@](CC(=O)O)(C(=O)NC2CCN(CC3=CCCC3)CC2)C1 nan
CHEMBL4447653 169799 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 487 8 2 4 4.3 Cc1cccc(Cl)c1CN1C[C@H](C)[C@](CC(=O)O)(C(=O)NC2CCN(CC3=CCCC3)CC2)C1 nan
71293692 172452 16 None - 0 Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 555 8 2 4 5.4 C[C@H]1CN(Cc2c(Cl)cccc2C(F)(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCCC2)CC1 nan
CHEMBL4518556 172452 16 None - 0 Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 555 8 2 4 5.4 C[C@H]1CN(Cc2c(Cl)cccc2C(F)(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCCC2)CC1 nan
71293607 173301 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 541 8 2 4 5.0 C[C@H]1CN(Cc2c(Cl)cccc2C(F)(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCC2)CC1 nan
CHEMBL4539605 173301 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 541 8 2 4 5.0 C[C@H]1CN(Cc2c(Cl)cccc2C(F)(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCC2)CC1 nan
71293699 171658 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 521 8 2 4 5.0 C[C@H]1CN(Cc2c(Cl)cccc2Cl)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCCC2)CC1 nan
CHEMBL4474066 171658 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 521 8 2 4 5.0 C[C@H]1CN(Cc2c(Cl)cccc2Cl)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCCC2)CC1 nan
71293737 174889 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 537 9 2 4 5.3 C[C@H]1CN(Cc2c(Cl)cccc2C(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCCC2)CC1 nan
CHEMBL4577003 174889 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assayAntagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
ChEMBL 537 9 2 4 5.3 C[C@H]1CN(Cc2c(Cl)cccc2C(F)F)C[C@@]1(CC(=O)O)C(=O)NC1CCN(CC2=CCCCC2)CC1 nan
132072454 179144 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at human CX3CR1 expressed in CHO-K1 cells by PathHunter beta-arrestin assayAntagonist activity at human CX3CR1 expressed in CHO-K1 cells by PathHunter beta-arrestin assay
ChEMBL 558 6 2 8 4.7 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)[C@H](c3[nH]c4ccccc4c3CCn3cc(-c4cccc(Cl)c4)nn3)C[C@@H]21 10.1016/j.bmc.2020.115546
CHEMBL4744046 179144 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at human CX3CR1 expressed in CHO-K1 cells by PathHunter beta-arrestin assayAntagonist activity at human CX3CR1 expressed in CHO-K1 cells by PathHunter beta-arrestin assay
ChEMBL 558 6 2 8 4.7 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)[C@H](c3[nH]c4ccccc4c3CCn3cc(-c4cccc(Cl)c4)nn3)C[C@@H]21 10.1016/j.bmc.2020.115546
69440865 87941 0 None -2 2 Human 8.0 pKi = 8 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 426 8 3 7 3.8 CC(C)C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]c(=O)sc12 10.1021/jm3012273
CHEMBL2349306 87941 0 None -2 2 Human 8.0 pKi = 8 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 426 8 3 7 3.8 CC(C)C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]c(=O)sc12 10.1021/jm3012273
59799570 87975 0 None 5 2 Human 7.0 pKi = 7 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 375 8 3 8 3.5 CCC[C@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349339 87975 0 None 5 2 Human 7.0 pKi = 7 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 375 8 3 8 3.5 CCC[C@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
71625506 87951 0 None 58 2 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 481 8 3 8 5.1 CC(C)C[C@H](CO)Nc1nc(S[C@H](C)c2ccccc2Br)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349315 87951 0 None 58 2 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 481 8 3 8 5.1 CC(C)C[C@H](CO)Nc1nc(S[C@H](C)c2ccccc2Br)nc2nc(N)sc12 10.1021/jm3012273
71625504 87926 0 None 4 2 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 417 10 3 8 4.2 CC(C)C[C@H](CO)Nc1nc(SCCCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349183 87926 0 None 4 2 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 417 10 3 8 4.2 CC(C)C[C@H](CO)Nc1nc(SCCCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
71624890 87927 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 422 8 3 8 2.2 CC(C)C[C@H](CO)Nc1nc(S(=O)(=O)Cc2ccccc2)nc2[nH]c(=O)sc12 10.1021/jm3012273
CHEMBL2349184 87927 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 422 8 3 8 2.2 CC(C)C[C@H](CO)Nc1nc(S(=O)(=O)Cc2ccccc2)nc2[nH]c(=O)sc12 10.1021/jm3012273
11857680 97181 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 347 6 3 8 2.8 C[C@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL271013 97181 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 347 6 3 8 2.8 C[C@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
71625274 87962 0 None 33 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 414 8 3 9 3.7 CC(C)C[C@H](CO)Nc1nc(SCc2ccccc2C#N)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349326 87962 0 None 33 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 414 8 3 9 3.7 CC(C)C[C@H](CO)Nc1nc(SCc2ccccc2C#N)nc2nc(N)sc12 10.1021/jm3012273
71625145 87930 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 417 8 3 8 4.6 CC(C)C[C@@H](Nc1nc(SCc2ccccc2)nc2nc(N)sc12)C(C)(C)O 10.1021/jm3012273
CHEMBL2349187 87930 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 417 8 3 8 4.6 CC(C)C[C@@H](Nc1nc(SCc2ccccc2)nc2nc(N)sc12)C(C)(C)O 10.1021/jm3012273
71625390 87967 0 None -4 2 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 414 8 3 9 3.7 CC(C)C[C@H](CO)Nc1nc(SCc2ccc(C#N)cc2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349331 87967 0 None -4 2 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 414 8 3 9 3.7 CC(C)C[C@H](CO)Nc1nc(SCc2ccc(C#N)cc2)nc2nc(N)sc12 10.1021/jm3012273
71625505 87950 0 None 204 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 481 8 3 8 5.1 CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2ccccc2Br)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349314 87950 0 None 204 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 481 8 3 8 5.1 CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2ccccc2Br)nc2nc(N)sc12 10.1021/jm3012273
66622526 87954 0 None 64 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 415 8 3 8 3.7 CCC[C@H](CO)Nc1nc(S[C@@H](C)c2cccc(C#N)c2)nc2[nH]c(=O)sc12 10.1021/jm3012273
CHEMBL2349318 87954 0 None 64 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 415 8 3 8 3.7 CCC[C@H](CO)Nc1nc(S[C@@H](C)c2cccc(C#N)c2)nc2[nH]c(=O)sc12 10.1021/jm3012273
71625503 87925 0 None 19 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 403 9 3 8 3.8 CC(C)C[C@H](CO)Nc1nc(SCCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349182 87925 0 None 19 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 403 9 3 8 3.8 CC(C)C[C@H](CO)Nc1nc(SCCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
11964663 87947 0 None 117 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 403 8 3 8 4.3 CC(C)C[C@H](CO)Nc1nc(S[C@H](C)c2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349311 87947 0 None 117 2 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 403 8 3 8 4.3 CC(C)C[C@H](CO)Nc1nc(S[C@H](C)c2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
71625146 87956 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 389 6 3 8 3.8 CC(C)(C)[C@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349320 87956 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 389 6 3 8 3.8 CC(C)(C)[C@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
71720196 87924 0 None 10 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 425 8 3 8 3.9 CCC[C@H](CO)Nc1nc(S[C@@H](C)c2cnccc2Cl)nc2[nH]c(=O)sc12 10.1021/jm3012273
CHEMBL2349181 87924 0 None 10 2 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 425 8 3 8 3.9 CCC[C@H](CO)Nc1nc(S[C@@H](C)c2cnccc2Cl)nc2[nH]c(=O)sc12 10.1021/jm3012273
71625021 87939 0 None 10 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 402 8 3 8 3.3 CC(C)C[C@@H](Nc1nc(SCc2ccccc2)nc2nc(N)sc12)C(N)=O 10.1021/jm3012273
CHEMBL2349304 87939 0 None 10 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 402 8 3 8 3.3 CC(C)C[C@@H](Nc1nc(SCc2ccccc2)nc2nc(N)sc12)C(N)=O 10.1021/jm3012273
71625143 87973 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 409 7 3 8 4.1 Nc1nc2nc(SCc3ccccc3)nc(N[C@@H](CO)c3ccccc3)c2s1 10.1021/jm3012273
CHEMBL2349337 87973 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 409 7 3 8 4.1 Nc1nc2nc(SCc3ccccc3)nc(N[C@@H](CO)c3ccccc3)c2s1 10.1021/jm3012273
71625272 87960 0 None 9 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 407 8 3 8 3.9 CC(C)C[C@H](CO)Nc1nc(SCc2ccccc2F)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349324 87960 0 None 9 2 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 407 8 3 8 3.9 CC(C)C[C@H](CO)Nc1nc(SCc2ccccc2F)nc2nc(N)sc12 10.1021/jm3012273
11964579 87955 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 481 9 3 10 3.7 CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2cccc(S(C)(=O)=O)c2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349319 87955 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 481 9 3 10 3.7 CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2cccc(S(C)(=O)=O)c2)nc2nc(N)sc12 10.1021/jm3012273
69442228 87928 0 None 1 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 406 8 3 7 2.5 CC(C)C[C@H](CO)Nc1nc([S+]([O-])Cc2ccccc2)nc2[nH]c(=O)sc12 10.1021/jm3012273
CHEMBL2349185 87928 0 None 1 2 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 406 8 3 7 2.5 CC(C)C[C@H](CO)Nc1nc([S+]([O-])Cc2ccccc2)nc2[nH]c(=O)sc12 10.1021/jm3012273
12073809 154763 0 None - 1 Human 4.5 pKi = 4.5 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 348 6 3 7 2.5 C[C@H](CO)Nc1nc(SCc2ccccc2)nc2[nH]c(=O)sc12 10.1021/jm3012273
CHEMBL402986 154763 0 None - 1 Human 4.5 pKi = 4.5 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 348 6 3 7 2.5 C[C@H](CO)Nc1nc(SCc2ccccc2)nc2[nH]c(=O)sc12 10.1021/jm3012273
11965767 87946 31 None 33 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 403 8 3 8 4.3 CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349310 87946 31 None 33 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 403 8 3 8 4.3 CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
57692074 87957 0 None 2 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 390 8 3 7 3.5 CC(C)C[C@H](CO)Nc1nc(SCc2ccccc2)nc2[nH]c(=O)sc12 10.1021/jm3012273
CHEMBL2349321 87957 0 None 2 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 390 8 3 7 3.5 CC(C)C[C@H](CO)Nc1nc(SCc2ccccc2)nc2[nH]c(=O)sc12 10.1021/jm3012273
71625276 87964 0 None 6 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 467 8 3 8 4.5 CC(C)C[C@H](CO)Nc1nc(SCc2cccc(Br)c2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349328 87964 0 None 6 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 467 8 3 8 4.5 CC(C)C[C@H](CO)Nc1nc(SCc2cccc(Br)c2)nc2nc(N)sc12 10.1021/jm3012273
71625022 87940 0 None 18 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 403 8 3 8 3.9 CC(C)C[C@@H](Nc1nc(SCc2ccccc2)nc2nc(N)sc12)C(=O)O 10.1021/jm3012273
CHEMBL2349305 87940 0 None 18 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 403 8 3 8 3.9 CC(C)C[C@@H](Nc1nc(SCc2ccccc2)nc2nc(N)sc12)C(=O)O 10.1021/jm3012273
71625392 87942 0 None -5 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 390 8 3 9 3.2 CC(C)C[C@H](CO)Nc1nc(SCc2ccccn2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349307 87942 0 None -5 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 390 8 3 9 3.2 CC(C)C[C@H](CO)Nc1nc(SCc2ccccn2)nc2nc(N)sc12 10.1021/jm3012273
71625271 87958 0 None 436 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 467 8 3 8 4.5 CC(C)C[C@H](CO)Nc1nc(SCc2ccccc2Br)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349322 87958 0 None 436 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 467 8 3 8 4.5 CC(C)C[C@H](CO)Nc1nc(SCc2ccccc2Br)nc2nc(N)sc12 10.1021/jm3012273
11964664 87952 0 None 301 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 421 8 3 8 4.5 CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2ccccc2F)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349316 87952 0 None 301 2 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 421 8 3 8 4.5 CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2ccccc2F)nc2nc(N)sc12 10.1021/jm3012273
71625625 87953 0 None 309 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 414 8 3 9 4.0 CCC[C@H](CO)Nc1nc(S[C@@H](C)c2cccc(C#N)c2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349317 87953 0 None 309 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 414 8 3 9 4.0 CCC[C@H](CO)Nc1nc(S[C@@H](C)c2cccc(C#N)c2)nc2nc(N)sc12 10.1021/jm3012273
71625019 87937 0 None 97 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 451 8 2 9 4.6 COC(=O)[C@@H](CC(C)C)Nc1nc(SCc2ccccc2Cl)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349302 87937 0 None 97 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 451 8 2 9 4.6 COC(=O)[C@@H](CC(C)C)Nc1nc(SCc2ccccc2Cl)nc2nc(N)sc12 10.1021/jm3012273
69441619 87929 0 None 13 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 374 8 3 7 2.8 CC(C)C[C@H](CO)Nc1nc(OCc2ccccc2)nc2[nH]c(=O)sc12 10.1021/jm3012273
CHEMBL2349186 87929 0 None 13 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 374 8 3 7 2.8 CC(C)C[C@H](CO)Nc1nc(OCc2ccccc2)nc2[nH]c(=O)sc12 10.1021/jm3012273
71625389 87966 0 None 33 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 467 8 3 8 4.5 CC(C)C[C@H](CO)Nc1nc(SCc2ccc(Br)cc2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349330 87966 0 None 33 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 467 8 3 8 4.5 CC(C)C[C@H](CO)Nc1nc(SCc2ccc(Br)cc2)nc2nc(N)sc12 10.1021/jm3012273
58230405 87971 0 None 10 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 389 8 3 8 3.8 CC(C)C[C@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349335 87971 0 None 10 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 389 8 3 8 3.8 CC(C)C[C@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
71718998 87923 0 None 85 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 439 8 3 8 4.1 CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2cc(Cl)ccn2)nc2[nH]c(=O)sc12 10.1021/jm3012273
CHEMBL2349180 87923 0 None 85 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 439 8 3 8 4.1 CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2cc(Cl)ccn2)nc2[nH]c(=O)sc12 10.1021/jm3012273
58230407 87959 1 None 34 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 423 8 3 8 4.4 CC(C)C[C@H](CO)Nc1nc(SCc2ccccc2Cl)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349323 87959 1 None 34 2 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 423 8 3 8 4.4 CC(C)C[C@H](CO)Nc1nc(SCc2ccccc2Cl)nc2nc(N)sc12 10.1021/jm3012273
11858153 87970 0 None -26 2 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 362 7 3 7 2.9 CC[C@H](CO)Nc1nc(SCc2ccccc2)nc2[nH]c(=O)sc12 10.1021/jm3012273
CHEMBL2349334 87970 0 None -26 2 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 362 7 3 7 2.9 CC[C@H](CO)Nc1nc(SCc2ccccc2)nc2[nH]c(=O)sc12 10.1021/jm3012273
71716556 87922 0 None 181 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 438 8 3 9 4.4 CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2cc(Cl)ccn2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349179 87922 0 None 181 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 438 8 3 9 4.4 CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2cc(Cl)ccn2)nc2nc(N)sc12 10.1021/jm3012273
71625024 87972 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 389 8 3 8 3.8 CC(C)C[C@@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349336 87972 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 389 8 3 8 3.8 CC(C)C[C@@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
71625144 87974 0 None -4 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 375 7 3 8 3.4 CC(C)[C@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349338 87974 0 None -4 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 375 7 3 8 3.4 CC(C)[C@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
71625501 87943 0 None 7 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 390 8 3 9 3.2 CC(C)C[C@H](CO)Nc1nc(SCc2cccnc2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349308 87943 0 None 7 2 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 390 8 3 9 3.2 CC(C)C[C@H](CO)Nc1nc(SCc2cccnc2)nc2nc(N)sc12 10.1021/jm3012273
11857488 87948 5 None 26 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 404 8 3 7 4.1 CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2ccccc2)nc2[nH]c(=O)sc12 10.1021/jm3012273
CHEMBL2349312 87948 5 None 26 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 404 8 3 7 4.1 CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2ccccc2)nc2[nH]c(=O)sc12 10.1021/jm3012273
71625273 87961 0 None 21 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 403 8 3 8 4.1 Cc1ccccc1CSc1nc(N[C@@H](CO)CC(C)C)c2sc(N)nc2n1 10.1021/jm3012273
CHEMBL2349325 87961 0 None 21 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 403 8 3 8 4.1 Cc1ccccc1CSc1nc(N[C@@H](CO)CC(C)C)c2sc(N)nc2n1 10.1021/jm3012273
71625391 87969 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 425 8 3 8 4.1 CC(C)C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349333 87969 0 None 1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 425 8 3 8 4.1 CC(C)C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2nc(N)sc12 10.1021/jm3012273
9885291 97835 0 None -4 2 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 361 7 3 8 3.1 CC[C@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL274737 97835 0 None -4 2 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 361 7 3 8 3.1 CC[C@H](CO)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
11857486 87949 0 None 169 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 404 8 3 7 4.1 CC(C)C[C@H](CO)Nc1nc(S[C@H](C)c2ccccc2)nc2[nH]c(=O)sc12 10.1021/jm3012273
CHEMBL2349313 87949 0 None 169 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 404 8 3 7 4.1 CC(C)C[C@H](CO)Nc1nc(S[C@H](C)c2ccccc2)nc2[nH]c(=O)sc12 10.1021/jm3012273
21035680 87968 0 None 69 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 485 8 3 8 4.7 CC(C)C[C@H](CO)Nc1nc(SCc2ccc(Br)cc2F)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349332 87968 0 None 69 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 485 8 3 8 4.7 CC(C)C[C@H](CO)Nc1nc(SCc2ccc(Br)cc2F)nc2nc(N)sc12 10.1021/jm3012273
71625020 87938 0 None 234 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 417 8 2 9 4.0 COC(=O)[C@@H](CC(C)C)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349303 87938 0 None 234 2 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 417 8 2 9 4.0 COC(=O)[C@@H](CC(C)C)Nc1nc(SCc2ccccc2)nc2nc(N)sc12 10.1021/jm3012273
71625502 87944 0 None 10 2 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 390 8 3 9 3.2 CC(C)C[C@H](CO)Nc1nc(SCc2ccncc2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349309 87944 0 None 10 2 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 390 8 3 9 3.2 CC(C)C[C@H](CO)Nc1nc(SCc2ccncc2)nc2nc(N)sc12 10.1021/jm3012273
71624891 87936 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 437 9 3 8 4.8 CC(C)C[C@H](CCO)Nc1nc(SCc2ccccc2Cl)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349301 87936 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 437 9 3 8 4.8 CC(C)C[C@H](CCO)Nc1nc(SCc2ccccc2Cl)nc2nc(N)sc12 10.1021/jm3012273
58230406 87965 0 None 21 2 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 414 8 3 9 3.7 CC(C)C[C@H](CO)Nc1nc(SCc2cccc(C#N)c2)nc2nc(N)sc12 10.1021/jm3012273
CHEMBL2349329 87965 0 None 21 2 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 414 8 3 9 3.7 CC(C)C[C@H](CO)Nc1nc(SCc2cccc(C#N)c2)nc2nc(N)sc12 10.1021/jm3012273
71625275 87963 0 None 5 2 Human 7.0 pKi = 7 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 419 9 3 9 3.8 COc1ccccc1CSc1nc(N[C@@H](CO)CC(C)C)c2sc(N)nc2n1 10.1021/jm3012273
CHEMBL2349327 87963 0 None 5 2 Human 7.0 pKi = 7 Binding
Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysisDisplacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis
ChEMBL 419 9 3 9 3.8 COc1ccccc1CSc1nc(N[C@@H](CO)CC(C)C)c2sc(N)nc2n1 10.1021/jm3012273