GPCRdb

Initializing potency table...

Ligand source activities (1 row/activity)

Affinity
Potency

Search:

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

CHEMBL2349179	88384	None	0	Human	Binding	Ki	=	6.20	8.21	181	2	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	438.1	8	3	9	4.39	CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2cc(Cl)ccn2)nc2nc(N)sc12	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349180	88385	None	0	Human	Binding	Ki	=	5.80	8.24	85	2	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	439.1	8	3	8	4.10	CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2cc(Cl)ccn2)nc2[nH]c(=O)sc12	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349181	88386	None	0	Human	Binding	Ki	=	21.00	7.68	10	2	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	425.1	8	3	8	3.85	CCC[C@H](CO)Nc1nc(S[C@@H](C)c2cnccc2Cl)nc2[nH]c(=O)sc12	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349182	88387	None	0	Human	Binding	Ki	=	18.00	7.75	19	2	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	403.1	9	3	8	3.82	CC(C)C[C@H](CO)Nc1nc(SCCc2ccccc2)nc2nc(N)sc12	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349183	88388	None	0	Human	Binding	Ki	=	110.00	6.96	4	2	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	417.2	10	3	8	4.21	CC(C)C[C@H](CO)Nc1nc(SCCCc2ccccc2)nc2nc(N)sc12	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349184	88389	None	0	Human	Binding	Ki	=	110.00	6.96	-1	2	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	422.1	8	3	8	2.17	CC(C)C[C@H](CO)Nc1nc(S(=O)(=O)Cc2ccccc2)nc2[nH]c(=O)sc12	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349185	88390	None	0	Human	Binding	Ki	=	280.00	6.55	1	2	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	406.1	8	3	7	2.51	CC(C)C[C@H](CO)Nc1nc([S+]([O-])Cc2ccccc2)nc2[nH]c(=O)sc12	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349186	88391	None	0	Human	Binding	Ki	=	44.00	7.36	13	2	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	374.1	8	3	7	2.78	CC(C)C[C@H](CO)Nc1nc(OCc2ccccc2)nc2[nH]c(=O)sc12	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349187	88392	None	0	Human	Binding	Ki	=	1200.00	5.92	-	1	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	417.2	8	3	8	4.56	CC(C)C[C@@H](Nc1nc(SCc2ccccc2)nc2nc(N)sc12)C(C)(C)O	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349301	88398	None	0	Human	Binding	Ki	=	91.00	7.04	-	1	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	437.1	9	3	8	4.82	CC(C)C[C@H](CCO)Nc1nc(SCc2ccccc2Cl)nc2nc(N)sc12	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349302	88399	None	0	Human	Binding	Ki	=	43.00	7.37	97	2	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	451.1	8	2	9	4.61	COC(=O)[C@@H](CC(C)C)Nc1nc(SCc2ccccc2Cl)nc2nc(N)sc12	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349303	88400	None	0	Human	Binding	Ki	=	8.30	8.08	234	2	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	417.1	8	2	9	3.96	COC(=O)[C@@H](CC(C)C)Nc1nc(SCc2ccccc2)nc2nc(N)sc12	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349304	88401	None	0	Human	Binding	Ki	=	220.00	6.66	10	2	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	402.1	8	3	8	3.27	CC(C)C[C@@H](Nc1nc(SCc2ccccc2)nc2nc(N)sc12)C(N)=O	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349305	88402	None	0	Human	Binding	Ki	=	320.00	6.50	18	2	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	403.1	8	3	8	3.87	CC(C)C[C@@H](Nc1nc(SCc2ccccc2)nc2nc(N)sc12)C(=O)O	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349306	88403	None	0	Human	Binding	Ki	=	10.00	8.00	-2	2	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	426.1	8	3	7	3.77	CC(C)C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2[nH]c(=O)sc12	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349307	88404	None	0	Human	Binding	Ki	=	360.00	6.44	-5	2	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	390.1	8	3	9	3.17	CC(C)C[C@H](CO)Nc1nc(SCc2ccccn2)nc2nc(N)sc12	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349308	88405	None	0	Human	Binding	Ki	=	670.00	6.17	7	2	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	390.1	8	3	9	3.17	CC(C)C[C@H](CO)Nc1nc(SCc2cccnc2)nc2nc(N)sc12	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349309	88406	None	0	Human	Binding	Ki	=	900.00	6.05	10	2	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	390.1	8	3	9	3.17	CC(C)C[C@H](CO)Nc1nc(SCc2ccncc2)nc2nc(N)sc12	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349310	88408	None	36	Human	Binding	Ki	=	3.90	8.41	33	3	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	403.1	8	3	8	4.34	CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2ccccc2)nc2nc(N)sc12	https://dx.doi.org/10.1021/jm3012273
CHEMBL2349311	88409	None	0	Human	Binding	Ki	=	18.00	7.75	117	2	Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 hrs by scintillation counting analysis	ChEMBL	403.1	8	3	8	4.34	CC(C)C[C@H](CO)Nc1nc(S[C@H](C)c2ccccc2)nc2nc(N)sc12	https://dx.doi.org/10.1021/jm3012273

Showing 1 to 20 of 64 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)