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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

α-methylserine-O-phosphate	365	None	0	Human	Binding	pKi	None	-	4.40	-7	4	Unclassified	Guide to Pharmacology	199.0	4	4	4	-1.10	CC(N)(COP(=O)(O)O)C(=O)O	https://pubmed.ncbi.nlm.nih.gov/11138847
(+)-MCPG	2475	None	35	Human	Binding	pKi	None	-	3.20	-25	8	Unclassified	Guide to Pharmacology	209.1	3	3	3	0.64	C[C@@](N)(C(=O)O)c1ccc(C(=O)O)cc1	https://pubmed.ncbi.nlm.nih.gov/11138847
(1R,2S)-PHENYLPROPANOLAMINE	27120	Functional	13	Rat	Binding	pKi	=	10000.00	5.00	-38	42	-	PDSP KiDatabase	151.1	2	2	2	1.07	C[C@H](N)[C@H](O)c1ccccc1	-
(1S,3R)-ACPD	33	None	30	Human	Binding	pKi	None	-	3.00	-562	15	Unclassified	Guide to Pharmacology	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://pubmed.ncbi.nlm.nih.gov/11138847
(1S,3R)-ACPD	33	None	30	Human	Binding	pKi	None	-	3.10	-562	15	Unclassified	Guide to Pharmacology	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://pubmed.ncbi.nlm.nih.gov/11138847
AMN082	402	None	22	Human	Binding	EC50	=	64.00	7.19	-	2	Agonist activity at human mGluR7b expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL	392.2	9	2	2	5.75	c1ccc(C(NCCNC(c2ccccc2)c2ccccc2)c2ccccc2)cc1	https://dx.doi.org/10.1021/acsmedchemlett.2c00529
Cathinone, (-)	218812	Functional	0	Rat	Binding	pKi	=	10000.00	5.00	-13	40	-	PDSP KiDatabase	149.1	2	1	2	1.22	CC(N)C(=O)c1ccccc1	-
CHEMBL1921961	68814	None	3	Rat	Binding	EC50	=	2900.00	5.54	-	4	Positive allosteric modulator activity at rat mGlu7 receptor at 10 uM by thallium flux assay	ChEMBL	393.1	3	1	4	3.30	O=C(Nc1ccc(N2C(=O)[C@H]3[C@H]4C=C[C@H](C4)[C@H]3C2=O)c(Cl)c1)c1ccccn1	https://dx.doi.org/10.1021/jm200956q
CHEMBL285843	99919	Functional	47	Human	Binding	pKi	=	10000.00	5.00	-25	8	-	PDSP KiDatabase	183.0	4	4	3	-1.03	NC(CCP(=O)(O)O)C(=O)O	-
CHEMBL4160748	162172	None	38	Human	Binding	EC50	=	650.00	6.19	-	5	Agonist activity at mGlu7 (unknown origin)	ChEMBL	357.1	2	0	4	4.32	COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F	https://dx.doi.org/10.1039/C8MD00524A
CHEMBL4160748	162172	None	38	Human	Binding	EC50	=	649.00	6.19	-	5	Positive allosteric modulation of mGluR7 (unknown origin)	ChEMBL	357.1	2	0	4	4.32	COc1ccc(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1F	https://dx.doi.org/10.1016/j.bmcl.2022.129106
CHEMBL4161847	162240	None	0	Human	Binding	IC50	=	1500.00	5.82	-	2	Negative allosteric modulation of mGlu7 (unknown origin) in cells expressing G protein-regulated inwardly rectifying potassium channels (GIRKs) assessed as inhibition of L-AP4-induced response measured by thallium flux assay	ChEMBL	436.1	8	1	7	4.22	CCCOc1ccc(C(=O)Nc2cc(OC(F)(F)F)ccc2-n2cncn2)cc1OC	https://dx.doi.org/10.1016/j.bmcl.2022.128923
CHEMBL4161847	162240	None	0	Human	Binding	IC50	=	1584.89	5.80	-	2	Negative allosteric modulation of mGlu7 (unknown origin) in cells expressing G protein-regulated inwardly rectifying potassium channels (GIRKs) assessed as inhibition of L-AP4-induced response measured by thallium flux assay	ChEMBL	436.1	8	1	7	4.22	CCCOc1ccc(C(=O)Nc2cc(OC(F)(F)F)ccc2-n2cncn2)cc1OC	https://dx.doi.org/10.1016/j.bmcl.2022.128923
CHEMBL4165849	162494	None	0	Human	Binding	IC50	=	5200.00	5.28	-	2	Negative allosteric modulation of mGlu7 (unknown origin) in cells expressing G protein-regulated inwardly rectifying potassium channels (GIRKs) assessed as inhibition of L-AP4-induced response measured by thallium flux assay	ChEMBL	436.1	7	1	7	4.21	COc1cc(C(=O)Nc2cc(OC(F)(F)F)ccc2-n2cncn2)ccc1OC(C)C	https://dx.doi.org/10.1016/j.bmcl.2022.128923
CHEMBL4165849	162494	None	0	Human	Binding	IC50	=	5011.87	5.30	-	2	Negative allosteric modulation of mGlu7 (unknown origin) in cells expressing G protein-regulated inwardly rectifying potassium channels (GIRKs) assessed as inhibition of L-AP4-induced response measured by thallium flux assay	ChEMBL	436.1	7	1	7	4.21	COc1cc(C(=O)Nc2cc(OC(F)(F)F)ccc2-n2cncn2)ccc1OC(C)C	https://dx.doi.org/10.1016/j.bmcl.2022.128923
CHEMBL4168668	162672	None	0	Human	Binding	EC50	=	600.00	6.22	-	4	Agonist activity at mGlu7 (unknown origin)	ChEMBL	357.1	2	0	4	4.32	COc1cc(F)c(-c2c(C)nn3c(C(F)(F)F)cc(C)nc23)c(F)c1	https://dx.doi.org/10.1039/C8MD00524A
CHEMBL4169114	162697	None	0	Human	Binding	IC50	=	1800.00	5.75	-	2	Negative allosteric modulation of mGlu7 (unknown origin) in cells expressing G protein-regulated inwardly rectifying potassium channels (GIRKs) assessed as inhibition of L-AP4-induced response measured by thallium flux assay	ChEMBL	422.1	7	1	7	3.83	CCOc1ccc(C(=O)Nc2cc(OC(F)(F)F)ccc2-n2cncn2)cc1OC	https://dx.doi.org/10.1016/j.bmcl.2022.128923
CHEMBL4169114	162697	None	0	Human	Binding	IC50	=	1584.89	5.80	-	2	Negative allosteric modulation of mGlu7 (unknown origin) in cells expressing G protein-regulated inwardly rectifying potassium channels (GIRKs) assessed as inhibition of L-AP4-induced response measured by thallium flux assay	ChEMBL	422.1	7	1	7	3.83	CCOc1ccc(C(=O)Nc2cc(OC(F)(F)F)ccc2-n2cncn2)cc1OC	https://dx.doi.org/10.1016/j.bmcl.2022.128923
CHEMBL4443735	170218	None	0	Human	Binding	EC50	=	29.20	7.54	-	1	Agonist activity at mGlu7 (unknown origin)	ChEMBL	352.2	5	1	2	2.98	O=C(NCc1ccccc1F)C1c2ccccc2CC(=O)N1CC1CC1	https://dx.doi.org/10.1039/C8MD00524A
CHEMBL4446107	170368	None	0	Human	Binding	EC50	=	740.00	6.13	-	3	Agonist activity at mGlu7 (unknown origin)	ChEMBL	371.1	3	0	4	4.57	CCc1nn2c(C(F)(F)F)cc(C)nc2c1-c1cc(F)c(OC)cc1F	https://dx.doi.org/10.1039/C8MD00524A

Showing 1 to 20 of 114 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)