GPCRdb

Ligand source activities (1 row/activity)

Potency
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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	137642920	164894	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	390	7	1	3	5.5	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4086893	164894	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	390	7	1	3	5.5	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1	10.1016/j.bmcl.2017.01.034
	134157586	160942	0	None	-3	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	366	8	1	3	5.5	O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3985509	160942	0	None	-3	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	366	8	1	3	5.5	O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	90407037	164067	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	377	8	1	3	5.3	CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4076902	164067	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	377	8	1	3	5.3	CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	90405670	171473	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	425	7	1	3	5.4	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccccc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4217143	171473	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	425	7	1	3	5.4	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccccc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	118707082	119785	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	309	4	1	3	3.3	COc1ccc(S(=O)(=O)Nc2c(C)cc(F)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311196	119785	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	309	4	1	3	3.3	COc1ccc(S(=O)(=O)Nc2c(C)cc(F)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	925016	119807	16	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	289	3	1	2	3.7	Cc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311314	119807	16	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	289	3	1	2	3.7	Cc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	137649416	164298	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4079893	164298	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2017.01.034
	82051616	166236	1	None	12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl	10.1016/j.bmcl.2017.01.034
	CHEMBL4101323	166236	1	None	12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl	10.1016/j.bmcl.2017.01.034
	975397	119813	9	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	335	5	1	4	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1OC	10.1016/j.bmcl.2014.05.012
	CHEMBL3311324	119813	9	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	335	5	1	4	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1OC	10.1016/j.bmcl.2014.05.012
	137634844	162895	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	412	9	1	3	6.1	CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4063239	162895	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	412	9	1	3	6.1	CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	137640323	163757	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	358	7	1	4	4.3	O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4073013	163757	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	358	7	1	4	4.3	O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	137653973	165463	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	354	6	2	3	4.3	Cc1cc(CCC(=O)O)ccc1OCc1cc(C(F)(F)F)ccc1O	10.1016/j.bmcl.2017.01.034
	CHEMBL4093067	165463	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	354	6	2	3	4.3	Cc1cc(CCC(=O)O)ccc1OCc1cc(C(F)(F)F)ccc1O	10.1016/j.bmcl.2017.01.034
	134133275	150421	0	None	-8	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	5	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3899885	150421	0	None	-8	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	5	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1	10.1016/j.bmcl.2016.10.054
	85472225	169540	0	None	-2	3	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse GPR120 by calcium flux assayAgonist activity at mouse GPR120 by calcium flux assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4171724	169540	0	None	-2	3	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse GPR120 by calcium flux assayAgonist activity at mouse GPR120 by calcium flux assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	134133797	150346	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	338	3	0	4	3.6	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3899190	150346	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	338	3	0	4	3.6	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	85472621	169582	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4172392	169582	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	145955668	169204	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	415	7	1	4	6.0	Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL4166208	169204	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	415	7	1	4	6.0	Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1021/acsmedchemlett.7b00233
	134149615	155355	0	None	1	3	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	CHEMBL3939004	155355	0	None	1	3	Mouse	7.0	pEC50	=	7.0	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	137640701	163868	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	427	9	1	4	6.2	CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4074388	163868	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	427	9	1	4	6.2	CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	137636217	162872	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	425	8	1	4	6.1	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4063013	162872	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	425	8	1	4	6.1	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C	10.1016/j.bmcl.2017.06.028
	137642920	164894	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	390	7	1	3	5.5	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4086893	164894	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	390	7	1	3	5.5	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(Cl)c1	10.1016/j.bmcl.2017.01.034
	90418476	169565	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	511	7	1	4	6.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4172136	169565	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	511	7	1	4	6.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	57521919	83052	0	None	23	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL2058532	83052	0	None	23	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL4207911	83052	0	None	23	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	137636217	162872	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	425	8	1	4	6.1	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4063013	162872	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	425	8	1	4	6.1	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C2CC2)c1C	10.1016/j.bmcl.2017.06.028
	134138099	154600	0	None	4	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	3	0	3	4.6	Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3932897	154600	0	None	4	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	3	0	3	4.6	Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	60195036	88496	0	None	-630	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	481	12	2	5	5.1	Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm3002026
	CHEMBL2163924	88496	0	None	-630	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	481	12	2	5	5.1	Cc1cc(OCCCS(C)(=O)=O)ccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm3002026
	137632299	163246	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	455	7	1	4	5.8	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4067368	163246	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	455	7	1	4	5.8	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	90406631	171213	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	503	7	1	3	6.1	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4213709	171213	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	503	7	1	3	6.1	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	137643228	165035	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	457	8	1	5	5.2	COc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4088620	165035	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	457	8	1	5	5.2	COc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	137647721	164609	0	None	1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.5	CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4083440	164609	0	None	1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.5	CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	59455584	163820	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	378	8	1	4	4.6	CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4073815	163820	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	378	8	1	4	4.6	CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	90406228	170481	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	453	8	1	3	5.9	CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2018.02.013
	CHEMBL4204928	170481	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	453	8	1	3	5.9	CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2018.02.013
	561372	65601	65	None	-20	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(OCc2ccccc2)cc1	10.1021/jm300215x
	CHEMBL1688452	65601	65	None	-20	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	256	6	1	2	3.3	O=C(O)CCc1ccc(OCc2ccccc2)cc1	10.1021/jm300215x
	86343591	170482	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	457	7	1	3	5.8	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4204946	170482	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	457	7	1	3	5.8	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)c(F)c1	10.1016/j.bmcl.2018.02.013
	134133275	150421	0	None	8	2	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	5	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3899885	150421	0	None	8	2	Mouse	7.9	pEC50	=	7.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	5	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3Cl)ccc2o1	10.1016/j.bmcl.2016.10.054
	137643958	165058	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	505	7	1	4	6.0	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Br)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4088889	165058	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	505	7	1	4	6.0	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Br)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	137657488	166459	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	441	7	1	4	5.5	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4104082	166459	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	441	7	1	4	5.5	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	90418753	169175	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	463	8	1	4	6.6	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4165803	169175	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	463	8	1	4	6.6	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	73777111	156489	0	None	-1	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3947837	156489	0	None	-1	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	25098573	9523	8	None	8	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm800970b
	5587	9523	8	None	8	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm800970b
	CHEMBL463785	9523	8	None	8	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm800970b
	134141270	153588	0	None	-3	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	334	8	1	3	4.6	CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3924759	153588	0	None	-3	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	334	8	1	3	4.6	CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	90418849	169475	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	473	7	1	4	6.5	Cc1cc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)cc1CCC(=O)O	10.1021/acsmedchemlett.7b00233
	CHEMBL4170501	169475	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	473	7	1	4	6.5	Cc1cc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)cc1CCC(=O)O	10.1021/acsmedchemlett.7b00233
	8190724	119806	6	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	359	4	1	3	4.3	Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311313	119806	6	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	359	4	1	3	4.3	Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	258072	86863	25	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	275	3	1	2	3.4	Cc1cc(C)c(NS(=O)(=O)c2ccccc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL2131154	86863	25	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	275	3	1	2	3.4	Cc1cc(C)c(NS(=O)(=O)c2ccccc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	91824000	119805	8	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1cccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311312	119805	8	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1cccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)c1	10.1016/j.bmcl.2014.05.012
	137647721	164609	0	None	1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.5	CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4083440	164609	0	None	1	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.5	CC(CC(=O)O)c1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	57521919	83052	0	None	23	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL2058532	83052	0	None	23	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL4207911	83052	0	None	23	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2cc(F)ccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	54586011	68582	0	None	-14	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	324	6	1	2	4.3	O=C(O)CCc1ccc(OCc2cccc(C(F)(F)F)c2)cc1	10.1021/jm300215x
	CHEMBL1773257	68582	0	None	-14	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	324	6	1	2	4.3	O=C(O)CCc1ccc(OCc2cccc(C(F)(F)F)c2)cc1	10.1021/jm300215x
	137640701	163868	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	427	9	1	4	6.2	CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4074388	163868	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	427	9	1	4	6.2	CCCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	134151903	160135	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	438	6	1	6	4.2	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3978465	160135	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	438	6	1	6	4.2	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	73777069	149447	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3891920	149447	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	73777174	157233	0	None	2	2	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3954140	157233	0	None	2	2	Mouse	5.9	pEC50	=	5.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	134136175	149458	0	None	1	3	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3892019	149458	0	None	1	3	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	643684	114292	63	None	8	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	298	15	2	2	5.1	CCCCCC[C@@H](O)C/C=C\CCCCCCCC(=O)O	10.1039/C7MD00130D
	CHEMBL3186422	114292	63	None	8	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	298	15	2	2	5.1	CCCCCC[C@@H](O)C/C=C\CCCCCCCC(=O)O	10.1039/C7MD00130D
	86343965	170590	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	443	7	1	3	5.5	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4206168	170590	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	443	7	1	3	5.5	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	90418650	164134	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4077787	164134	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	85470884	170783	2	None	2	5	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR120 in human HT-29 cells assessed as intracellular calcium fluxAgonist activity at GPR120 in human HT-29 cells assessed as intracellular calcium flux	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4208325	170783	2	None	2	5	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR120 in human HT-29 cells assessed as intracellular calcium fluxAgonist activity at GPR120 in human HT-29 cells assessed as intracellular calcium flux	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	134149615	155355	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	CHEMBL3939004	155355	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	90406583	171440	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	416	7	1	4	4.9	N#Cc1ccn(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(F)c1F	10.1016/j.bmcl.2018.02.013
	CHEMBL4216721	171440	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	416	7	1	4	4.9	N#Cc1ccn(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(F)c1F	10.1016/j.bmcl.2018.02.013
	134144000	156988	0	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3952043	156988	0	None	-1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	134154415	159473	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	447	6	1	5	6.3	Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1	10.1021/acsmedchemlett.6b00394
	CHEMBL3972870	159473	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	447	6	1	5	6.3	Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1	10.1021/acsmedchemlett.6b00394
	137640328	163763	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F	10.1016/j.bmcl.2017.06.028
	CHEMBL4073078	163763	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F	10.1016/j.bmcl.2017.06.028
	134133675	150040	0	None	2	3	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	318	8	1	3	4.1	CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3896714	150040	0	None	2	3	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	318	8	1	3	4.1	CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	1050	8683	94	None	-26	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm300215x
	11595431	8683	94	None	-26	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm300215x
	CHEMBL207881	8683	94	None	-26	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/jm300215x
	85471695	165448	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4092882	165448	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	137657736	166417	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	385	7	1	4	5.2	Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4103573	166417	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	385	7	1	4	5.2	Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	90405989	162739	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	383	7	1	3	5.3	Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4061340	162739	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	383	7	1	3	5.3	Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	137653883	165301	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	493	7	1	4	6.6	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)cc1C(F)(F)F	10.1016/j.bmcl.2017.06.028
	CHEMBL4091291	165301	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	493	7	1	4	6.6	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)cc1C(F)(F)F	10.1016/j.bmcl.2017.06.028
	11195	10654	0	None	-1	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	86280676	10654	0	None	-1	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	CHEMBL3941880	10654	0	None	-1	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	87055315	172536	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	349	8	2	3	4.7	CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1	10.1016/j.bmcl.2018.06.047
	CHEMBL4246850	172536	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	349	8	2	3	4.7	CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1	10.1016/j.bmcl.2018.06.047
	145986046	172691	0	None	19	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	437	10	1	6	4.3	CO[C@H]1C[C@H](Oc2ccc([N+](=O)[O-])c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4250196	172691	0	None	19	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	437	10	1	6	4.3	CO[C@H]1C[C@H](Oc2ccc([N+](=O)[O-])c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	142738582	191299	0	None	-42	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at FFAR4 (unknown origin)Agonist activity at FFAR4 (unknown origin)	ChEMBL	293	4	2	1	4.5	Cc1ccc(C)c(-c2cc3cc(CCC(=O)O)ccc3[nH]2)c1	10.1021/acs.jmedchem.1c00031
	CHEMBL4847662	191299	0	None	-42	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at FFAR4 (unknown origin)Agonist activity at FFAR4 (unknown origin)	ChEMBL	293	4	2	1	4.5	Cc1ccc(C)c(-c2cc3cc(CCC(=O)O)ccc3[nH]2)c1	10.1021/acs.jmedchem.1c00031
	134157207	160990	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	386	7	1	3	5.3	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3985939	160990	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	386	7	1	3	5.3	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	134135468	151253	0	None	-1	2	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	389	4	1	3	4.8	O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3906716	151253	0	None	-1	2	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	389	4	1	3	4.8	O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1	10.1021/acsmedchemlett.6b00360
	134145700	155530	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	400	7	1	4	5.0	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3940429	155530	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	400	7	1	4	5.0	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	134155067	158085	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	401	7	1	5	4.4	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3960738	158085	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	401	7	1	5	4.4	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	137646995	164612	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	391	7	1	4	5.0	O=C(O)CCc1ccc(OCc2c(-c3ccccc3)noc2C(F)(F)F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4083499	164612	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	391	7	1	4	5.0	O=C(O)CCc1ccc(OCc2c(-c3ccccc3)noc2C(F)(F)F)cc1	10.1016/j.bmcl.2017.06.028
	137660451	166024	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	445	7	1	4	5.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4099026	166024	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	445	7	1	4	5.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	134151115	158978	0	None	-4	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	336	6	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3968537	158978	0	None	-4	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	336	6	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	90418653	144291	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL3754160	144291	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C	10.1021/acsmedchemlett.7b00233
	86343594	170376	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	461	7	1	3	5.6	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2F)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4203544	170376	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	461	7	1	3	5.6	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2F)c(F)c1	10.1016/j.bmcl.2018.02.013
	137641343	163836	0	None	117	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4074009	163836	0	None	117	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	134132142	151647	0	None	13	2	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	CHEMBL3909872	151647	0	None	13	2	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	134132142	151647	0	None	13	2	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3909872	151647	0	None	13	2	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	57522038	10659	60	None	6	3	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120Agonist activity at mouse GPR120	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	6490	10659	60	None	6	3	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120Agonist activity at mouse GPR120	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	CHEMBL2058533	10659	60	None	6	3	Mouse	7.8	pEC50	=	7.8	Functional	Agonist activity at mouse GPR120Agonist activity at mouse GPR120	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	137635671	162770	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4061699	162770	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	137632299	163246	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	455	7	1	4	5.8	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4067368	163246	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	455	7	1	4	5.8	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	137661886	166106	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	453	7	1	4	6.2	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4099943	166106	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	453	7	1	4	6.2	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C	10.1016/j.bmcl.2017.06.028
	137657968	166371	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4103081	166371	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	90418139	169360	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	443	7	1	4	5.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4168786	169360	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	443	7	1	4	5.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	90406219	171093	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	469	7	1	3	5.8	O=C(O)CCc1ccc(OCc2c(Br)ccn2-c2ccc(Cl)cc2)c(F)c1F	10.1016/j.bmcl.2018.02.013
	CHEMBL4212281	171093	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	469	7	1	3	5.8	O=C(O)CCc1ccc(OCc2c(Br)ccn2-c2ccc(Cl)cc2)c(F)c1F	10.1016/j.bmcl.2018.02.013
	90406961	170561	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	445	7	1	3	5.9	OCCCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F	10.1016/j.bmcl.2018.02.013
	CHEMBL4205879	170561	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	445	7	1	3	5.9	OCCCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F	10.1016/j.bmcl.2018.02.013
	90406842	171485	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	427	7	1	3	5.5	Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Br)cc2)c1C	10.1016/j.bmcl.2018.02.013
	CHEMBL4217252	171485	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	427	7	1	3	5.5	Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Br)cc2)c1C	10.1016/j.bmcl.2018.02.013
	85472222	169845	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	437	9	1	4	6.7	CCc1ccc(-c2nsc(C(C)C)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4176414	169845	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	437	9	1	4	6.7	CCc1ccc(-c2nsc(C(C)C)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	51349861	65603	0	None	-77	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/jm300215x
	CHEMBL1688454	65603	0	None	-77	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/jm300215x
	10466	173449	80	None	12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	272	15	2	2	4.5	O=C(O)CCCCCCCCCCCCCCCO	10.1039/C7MD00130D
	CHEMBL4281719	173449	80	None	12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	272	15	2	2	4.5	O=C(O)CCCCCCCCCCCCCCCO	10.1039/C7MD00130D
	134153222	159304	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3971461	159304	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1	10.1021/acs.jmedchem.6b00685
	134134149	150153	0	None	-2	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3897776	150153	0	None	-2	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	134155480	158030	0	None	38	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3960231	158030	0	None	38	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	137648785	164389	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	427	7	1	4	5.2	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4080995	164389	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	427	7	1	4	5.2	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	137655521	165768	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	467	8	1	4	6.1	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C4CC4)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4096332	165768	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	467	8	1	4	6.1	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C4CC4)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	25109512	196543	0	None	12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	382	10	1	5	4.8	O=C(O)CCCc1ccc(OCCN(c2ccccc2)c2nccs2)cc1	10.1021/jm800970b
	CHEMBL515995	196543	0	None	12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	382	10	1	5	4.8	O=C(O)CCCc1ccc(OCCN(c2ccccc2)c2nccs2)cc1	10.1021/jm800970b
	137641343	163836	0	None	117	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4074009	163836	0	None	117	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1ccc(OC(C)C)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	90418782	169862	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	513	7	1	4	6.6	O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4176642	169862	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	513	7	1	4	6.6	O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	90407441	170493	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	417	7	1	3	6.0	Cc1c(CCC(=O)O)ccc(OCc2c(Cl)ccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2018.02.013
	CHEMBL4205035	170493	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	417	7	1	3	6.0	Cc1c(CCC(=O)O)ccc(OCc2c(Cl)ccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2018.02.013
	54580132	68578	0	None	-3	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccccc2Br)cc1	10.1021/jm300215x
	CHEMBL1773253	68578	0	None	-3	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccccc2Br)cc1	10.1021/jm300215x
	7789	107461	88	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	300	16	2	2	5.3	CCCCCCC(O)CCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	CHEMBL292352	107461	88	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	300	16	2	2	5.3	CCCCCCC(O)CCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	86343595	171474	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	461	7	1	3	5.6	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)c(F)c2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4217161	171474	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	461	7	1	3	5.6	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)c(F)c2)c(F)c1	10.1016/j.bmcl.2018.02.013
	137646145	164803	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	385	7	1	4	5.2	Cc1c(CCC(=O)O)ccc(OCc2ncoc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4085643	164803	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	385	7	1	4	5.2	Cc1c(CCC(=O)O)ccc(OCc2ncoc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	57521809	83039	0	None	13	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058520	83039	0	None	13	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL4210970	83039	0	None	13	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	86294762	170894	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	477	7	1	3	6.2	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2F)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4209823	170894	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	477	7	1	3	6.2	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2F)c(F)c1	10.1016/j.bmcl.2018.02.013
	134133355	150314	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	413	6	1	5	4.2	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3898962	150314	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	413	6	1	5	4.2	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	137657488	166459	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	441	7	1	4	5.5	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4104082	166459	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	441	7	1	4	5.5	Cc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	134146386	155686	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3941726	155686	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	46892131	151449	2	None	-3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 expressed in CHO/NFAT-BLA cells assessed as effect on intracellular calcium concentration by Fluo-4 AM dye based FLIPR assayAgonist activity at human FFA4 expressed in CHO/NFAT-BLA cells assessed as effect on intracellular calcium concentration by Fluo-4 AM dye based FLIPR assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3908362	151449	2	None	-3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 expressed in CHO/NFAT-BLA cells assessed as effect on intracellular calcium concentration by Fluo-4 AM dye based FLIPR assayAgonist activity at human FFA4 expressed in CHO/NFAT-BLA cells assessed as effect on intracellular calcium concentration by Fluo-4 AM dye based FLIPR assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	134143163	152522	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	362	8	1	3	5.7	Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3916564	152522	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	362	8	1	3	5.7	Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	90406575	171133	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	455	8	1	4	5.4	COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2018.02.013
	CHEMBL4212717	171133	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	455	8	1	4	5.4	COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2018.02.013
	134136175	149458	0	None	-1	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3892019	149458	0	None	-1	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	145983493	172283	0	None	371	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	442	10	1	4	5.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4240607	172283	0	None	371	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	442	10	1	4	5.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	134146021	155843	0	None	-5	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	392	7	1	3	5.3	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3942922	155843	0	None	-5	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	392	7	1	3	5.3	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1	10.1016/j.bmcl.2016.10.054
	134154330	159659	0	None	1	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	340	7	1	3	4.5	O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3974501	159659	0	None	1	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	340	7	1	3	4.5	O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	137638355	163608	0	None	97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	318	6	1	2	4.6	Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4071290	163608	0	None	97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	318	6	1	2	4.6	Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	134147174	156482	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	6	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3947787	156482	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	6	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	137649360	164165	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	495	7	1	4	6.3	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4078286	164165	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	495	7	1	4	6.3	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	90418662	165720	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	395	8	1	4	5.6	CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4095819	165720	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	395	8	1	4	5.6	CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	73777175	150687	0	None	1	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3901994	150687	0	None	1	3	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	57521814	83044	0	None	10	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	362	8	1	3	5.0	COc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058525	83044	0	None	10	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	362	8	1	3	5.0	COc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	90418662	165720	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	395	8	1	4	5.6	CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4095819	165720	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	395	8	1	4	5.6	CCc1ccc(-c2sncc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	85470884	170783	2	None	-2	5	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant mouse GPR120 expressed in HEK293 cellsAgonist activity at recombinant mouse GPR120 expressed in HEK293 cells	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4208325	170783	2	None	-2	5	Mouse	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant mouse GPR120 expressed in HEK293 cellsAgonist activity at recombinant mouse GPR120 expressed in HEK293 cells	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	57521808	83038	0	None	-3	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1cccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	CHEMBL2058519	83038	0	None	-3	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1cccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	57521809	83039	0	None	13	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL2058520	83039	0	None	13	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL4210970	83039	0	None	13	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	346	7	1	2	5.3	Cc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmc.2017.10.040
	90442468	171261	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	456	8	1	5	4.8	COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1	10.1016/j.bmcl.2018.02.013
	CHEMBL4214224	171261	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	456	8	1	5	4.8	COc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1	10.1016/j.bmcl.2018.02.013
	134156096	158226	0	None	-5	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	400	8	1	3	6.2	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3961950	158226	0	None	-5	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	400	8	1	3	6.2	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	137638355	163608	0	None	97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	318	6	1	2	4.6	Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4071290	163608	0	None	97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	318	6	1	2	4.6	Cc1ccc(Cl)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	137642604	165296	0	None	41	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4091228	165296	0	None	41	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	137632403	163083	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	1	4	4.9	COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4065447	163083	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	1	4	4.9	COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	84481843	119812	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	333	5	1	3	4.2	Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(C)C)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311322	119812	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	333	5	1	3	4.2	Cc1cc(C)c(NS(=O)(=O)c2ccc(OC(C)C)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	8190727	119815	5	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	347	3	1	4	3.6	Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCCO3)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311326	119815	5	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	347	3	1	4	3.6	Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCCO3)c(C)c1	10.1016/j.bmcl.2014.05.012
	137632403	163083	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	1	4	4.9	COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4065447	163083	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	1	4	4.9	COc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	134153562	159502	0	None	-2	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	394	7	1	3	4.9	O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F	10.1016/j.bmcl.2016.10.054
	CHEMBL3973101	159502	0	None	-2	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	394	7	1	3	4.9	O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F	10.1016/j.bmcl.2016.10.054
	87055315	172536	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120Agonist activity at human GPR120	ChEMBL	349	8	2	3	4.7	CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1	10.1016/j.bmcl.2018.06.047
	CHEMBL4246850	172536	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120Agonist activity at human GPR120	ChEMBL	349	8	2	3	4.7	CC(C)Nc1ccccc1-c1cc(F)c(OCCCC(=O)O)c(F)c1	10.1016/j.bmcl.2018.06.047
	73777156	159494	0	None	-1	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3973034	159494	0	None	-1	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	137642604	165296	0	None	41	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4091228	165296	0	None	41	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	90418651	169192	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	469	8	1	4	6.6	CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	CHEMBL4166012	169192	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	469	8	1	4	6.6	CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	59455552	162820	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	384	7	1	4	4.7	Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4062462	162820	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	384	7	1	4	4.7	Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	134154417	159483	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3972973	159483	0	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	57521813	83043	0	None	-1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	400	7	1	2	6.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(C(F)(F)F)cc2)cc1	10.1021/jm300215x
	CHEMBL2058524	83043	0	None	-1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	400	7	1	2	6.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(C(F)(F)F)cc2)cc1	10.1021/jm300215x
	134134846	151017	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	337	3	0	3	4.2	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3904654	151017	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	337	3	0	3	4.2	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	54582149	68580	0	None	-33	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	281	6	1	3	3.2	N#Cc1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	CHEMBL1773255	68580	0	None	-33	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	281	6	1	3	3.2	N#Cc1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	134146958	156388	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	388	6	1	3	5.1	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3947070	156388	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	388	6	1	3	5.1	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	73777085	160009	0	None	-1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3977361	160009	0	None	-1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	90418650	164134	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL4077787	164134	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	90418650	164134	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4077787	164134	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	57521913	83045	0	None	2	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	376	9	1	3	5.3	CCOc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058526	83045	0	None	2	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	376	9	1	3	5.3	CCOc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	134145750	155924	0	None	3	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	324	6	1	2	4.6	O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3943430	155924	0	None	3	2	Mouse	5.7	pEC50	=	5.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	324	6	1	2	4.6	O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	134141029	153945	0	None	4	2	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	352	6	1	3	4.8	O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3927879	153945	0	None	4	2	Mouse	7.7	pEC50	=	7.7	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	352	6	1	3	4.8	O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	145984594	172712	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	436	9	1	6	4.2	CO[C@H]1C[C@H](Oc2cc3c(c(-c4cc(F)c(OCCCC(=O)O)c(F)c4)c2)OCO3)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4250664	172712	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	436	9	1	6	4.2	CO[C@H]1C[C@H](Oc2cc3c(c(-c4cc(F)c(OCCCC(=O)O)c(F)c4)c2)OCO3)C1	10.1016/j.bmcl.2018.06.047
	134156455	161100	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	394	6	1	5	4.3	Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	CHEMBL3986721	161100	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	394	6	1	5	4.3	Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	73777153	149601	0	None	-2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3893026	149601	0	None	-2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	137645347	164581	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	394	7	1	2	6.2	Cc1c(CCC(=O)O)ccc(OCc2ccccc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4083233	164581	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	394	7	1	2	6.2	Cc1c(CCC(=O)O)ccc(OCc2ccccc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	134147107	156655	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	417	3	1	3	5.5	O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3949142	156655	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	417	3	1	3	5.5	O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2	10.1021/acsmedchemlett.6b00360
	25150014	10657	55	None	-44	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm300215x
	3952	10657	55	None	-44	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm300215x
	CHEMBL449588	10657	55	None	-44	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/jm300215x
	137646188	164384	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	406	7	1	3	6.0	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12	10.1016/j.bmcl.2017.01.034
	CHEMBL4080936	164384	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	406	7	1	3	6.0	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12	10.1016/j.bmcl.2017.01.034
	137660451	166024	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	445	7	1	4	5.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4099026	166024	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	445	7	1	4	5.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	57521915	83047	0	None	15	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	378	8	1	3	5.7	CSc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058528	83047	0	None	15	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	378	8	1	3	5.7	CSc1ccc(-c2ccccc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	11195	10654	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	86280676	10654	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	CHEMBL3941880	10654	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	134152545	160256	0	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3979588	160256	0	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	137636733	162983	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	6	1	2	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br	10.1016/j.bmcl.2017.01.034
	CHEMBL4064298	162983	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	6	1	2	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br	10.1016/j.bmcl.2017.01.034
	90442039	169688	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	509	7	1	4	7.1	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	CHEMBL4173940	169688	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	509	7	1	4	7.1	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	57521916	83048	0	None	2	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2cc(Cl)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL2058529	83048	0	None	2	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2cc(Cl)ccc2-c2ccccc2)cc1	10.1021/jm300215x
	25098573	9523	8	None	8	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm300215x
	5587	9523	8	None	8	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm300215x
	CHEMBL463785	9523	8	None	8	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	10.1021/jm300215x
	23136411	65606	0	None	-11	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1021/jm300215x
	CHEMBL1688457	65606	0	None	-11	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2cccc(-c3ccccc3)c2)cc1	10.1021/jm300215x
	134143370	152581	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	442	7	1	6	4.0	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3916986	152581	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	442	7	1	6	4.0	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	145983824	172518	0	None	-6	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	484	13	1	4	6.3	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4246334	172518	0	None	-6	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	484	13	1	4	6.3	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	134129938	149218	0	None	263	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	414	6	1	4	5.0	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3890089	149218	0	None	263	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	414	6	1	4	5.0	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	134153298	159145	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	412	6	1	4	4.8	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3970166	159145	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	412	6	1	4	4.8	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	85472225	169540	0	None	2	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4171724	169540	0	None	2	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	134153546	159360	0	None	8	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3971857	159360	0	None	8	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	137636733	162983	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	6	1	2	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br	10.1016/j.bmcl.2017.01.034
	CHEMBL4064298	162983	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	6	1	2	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Br	10.1016/j.bmcl.2017.01.034
	82051652	165377	1	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	284	6	1	2	3.9	Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4092090	165377	1	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	284	6	1	2	3.9	Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	137654721	165518	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	328	8	1	3	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C	10.1016/j.bmcl.2017.01.034
	CHEMBL4093589	165518	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	328	8	1	3	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C	10.1016/j.bmcl.2017.01.034
	711134	119802	17	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	291	4	1	3	3.1	COc1ccc(S(=O)(=O)Nc2ccc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311305	119802	17	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	291	4	1	3	3.1	COc1ccc(S(=O)(=O)Nc2ccc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	137646188	164384	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	406	7	1	3	6.0	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12	10.1016/j.bmcl.2017.01.034
	CHEMBL4080936	164384	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	406	7	1	3	6.0	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c2ccccc12	10.1016/j.bmcl.2017.01.034
	134155277	158104	0	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl	10.1016/j.bmcl.2016.10.054
	CHEMBL3961009	158104	0	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl	10.1016/j.bmcl.2016.10.054
	1049	7151	75	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	4618	7151	75	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	5280934	7151	75	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	CHEMBL8739	7151	75	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	DB00132	7151	75	None	-1	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assayAgonist activity at human GPR120-G-alpha-16 fusion protein expressed in Flp-in HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm800970b
	90406335	170609	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	457	7	1	3	5.8	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1F	10.1016/j.bmcl.2018.02.013
	CHEMBL4206369	170609	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	457	7	1	3	5.8	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1F	10.1016/j.bmcl.2018.02.013
	134138318	154798	0	None	1	3	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	378	9	1	4	5.4	COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3934450	154798	0	None	1	3	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	378	9	1	4	5.4	COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1	10.1016/j.bmcl.2016.10.054
	134144214	157137	0	None	2	3	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	8	1	3	5.7	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3953203	157137	0	None	2	3	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	8	1	3	5.7	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	59455555	165495	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	399	7	1	4	5.5	Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4093383	165495	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	399	7	1	4	5.5	Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	73776979	150137	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	5	1	3	5.9	O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3897637	150137	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	5	1	3	5.9	O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	137654721	165518	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	328	8	1	3	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C	10.1016/j.bmcl.2017.01.034
	CHEMBL4093589	165518	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	328	8	1	3	4.4	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1OC(C)C	10.1016/j.bmcl.2017.01.034
	82051652	165377	1	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	284	6	1	2	3.9	Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4092090	165377	1	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	284	6	1	2	3.9	Cc1cccc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	137657736	166417	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	385	7	1	4	5.2	Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4103573	166417	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	385	7	1	4	5.2	Cc1c(CCC(=O)O)ccc(OCc2conc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	145986262	172624	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	428	8	1	4	4.7	O=C(O)CCCOc1c(F)cc(-c2cc(OC3CCOCC3)cc(F)c2F)cc1F	10.1016/j.bmcl.2018.06.047
	CHEMBL4248845	172624	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	428	8	1	4	4.7	O=C(O)CCCOc1c(F)cc(-c2cc(OC3CCOCC3)cc(F)c2F)cc1F	10.1016/j.bmcl.2018.06.047
	134154473	159153	0	None	218	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	370	6	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3970238	159153	0	None	218	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	370	6	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134139171	153041	0	None	2	3	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	6	1	3	5.4	Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3920591	153041	0	None	2	3	Mouse	7.6	pEC50	=	7.6	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	6	1	3	5.4	Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1	10.1016/j.bmcl.2016.10.054
	86343964	170399	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	421	7	1	3	5.5	Cc1cc(CCC(=O)O)ccc1OCc1c(C(F)(F)F)ccn1-c1ccc(F)cc1	10.1016/j.bmcl.2018.02.013
	CHEMBL4203774	170399	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	421	7	1	3	5.5	Cc1cc(CCC(=O)O)ccc1OCc1c(C(F)(F)F)ccn1-c1ccc(F)cc1	10.1016/j.bmcl.2018.02.013
	137647294	164731	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	461	8	1	4	6.9	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2-c2ccccc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4084679	164731	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	461	8	1	4	6.9	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2-c2ccccc2)c1C	10.1016/j.bmcl.2017.06.028
	90407659	171012	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	440	7	1	4	5.1	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1	10.1016/j.bmcl.2018.02.013
	CHEMBL4211144	171012	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	440	7	1	4	5.1	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1	10.1016/j.bmcl.2018.02.013
	134157586	160942	0	None	3	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	366	8	1	3	5.5	O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3985509	160942	0	None	3	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	366	8	1	3	5.5	O=C(O)CCCOc1ccc(-c2cc(Oc3ccccc3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	137636575	162680	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	479	7	1	4	6.0	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4060663	162680	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	479	7	1	4	6.0	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	134133675	150040	0	None	-2	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	318	8	1	3	4.1	CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3896714	150040	0	None	-2	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	318	8	1	3	4.1	CCOc1ccc(F)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	90404813	171287	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	473	7	1	3	6.3	CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1)C(=O)O	10.1016/j.bmcl.2018.02.013
	CHEMBL4214698	171287	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	473	7	1	3	6.3	CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1)C(=O)O	10.1016/j.bmcl.2018.02.013
	57521812	83042	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	410	7	1	2	5.7	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Br)cc2)cc1	10.1021/jm300215x
	CHEMBL2058523	83042	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	410	7	1	2	5.7	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Br)cc2)cc1	10.1021/jm300215x
	137633536	163074	0	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4065397	163074	0	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	134154330	159659	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	340	7	1	3	4.5	O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3974501	159659	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	340	7	1	3	4.5	O=C(O)CCCOc1ccc(-c2ccccc2OC(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	134148110	156349	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3946820	156349	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134138802	154697	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3933619	154697	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	46892131	151449	2	None	-3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3908362	151449	2	None	-3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	137661388	166019	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4098969	166019	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C	10.1016/j.bmcl.2017.01.034
	134133297	150557	0	None	-3	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	372	7	1	3	4.9	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3900990	150557	0	None	-3	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	372	7	1	3	4.9	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	57521811	83041	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Cl)cc2)cc1	10.1021/jm300215x
	CHEMBL2058522	83041	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(Cl)cc2)cc1	10.1021/jm300215x
	24825492	156321	0	None	-9	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	333	6	2	2	4.1	O=C(O)CCc1ccc(NCc2cccc(Br)c2)cc1	10.1021/jm300215x
	CHEMBL394666	156321	0	None	-9	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	333	6	2	2	4.1	O=C(O)CCc1ccc(NCc2cccc(Br)c2)cc1	10.1021/jm300215x
	85472227	168967	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	519	7	1	4	6.8	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4162566	168967	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	519	7	1	4	6.8	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1	10.1021/acsmedchemlett.7b00233
	134149615	155355	0	None	1	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	CHEMBL3939004	155355	0	None	1	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	73777174	157233	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3954140	157233	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	145960576	168931	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	527	8	1	5	6.6	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4161929	168931	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	527	8	1	5	6.6	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	134145195	157202	0	None	-	1	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	392	5	1	5	4.4	Fc1ccc(OC(F)(F)F)cc1-c1ccc2oc(CCc3nn[nH]n3)cc2c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3953859	157202	0	None	-	1	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	392	5	1	5	4.4	Fc1ccc(OC(F)(F)F)cc1-c1ccc2oc(CCc3nn[nH]n3)cc2c1	10.1016/j.bmcl.2016.10.054
	1052	9101	85	None	3	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2014.05.012
	3323	9101	85	None	3	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2014.05.012
	5280450	9101	85	None	3	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2014.05.012
	CHEMBL267476	9101	85	None	3	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2014.05.012
	DB14104	9101	85	None	3	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	10.1016/j.bmcl.2014.05.012
	900631	119814	17	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	333	3	1	4	3.2	Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCO3)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311325	119814	17	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	333	3	1	4	3.2	Cc1cc(C)c(NS(=O)(=O)c2ccc3c(c2)OCCO3)c(C)c1	10.1016/j.bmcl.2014.05.012
	118707173	119816	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	331	6	1	3	3.8	C=CCc1cc(C)c(NS(=O)(=O)c2ccc(OC)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311327	119816	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	331	6	1	3	3.8	C=CCc1cc(C)c(NS(=O)(=O)c2ccc(OC)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	137633536	163074	0	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4065397	163074	0	None	-4	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	137661388	166019	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4098969	166019	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1c(CCC(=O)O)ccc(OCc2ccccc2SC(F)(F)F)c1C	10.1016/j.bmcl.2017.01.034
	1050	8683	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assayAgonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2020.127650
	11595431	8683	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assayAgonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2020.127650
	CHEMBL207881	8683	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assayAgonist activity at human FFA4 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at every 1 secs for 60 secs by Calcium-3 dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2020.127650
	825631	119803	15	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	291	4	1	3	3.1	COc1ccc(S(=O)(=O)Nc2c(C)cccc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311306	119803	15	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	291	4	1	3	3.1	COc1ccc(S(=O)(=O)Nc2c(C)cccc2C)cc1	10.1016/j.bmcl.2014.05.012
	841618	119810	18	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	309	3	1	2	4.1	Cc1cc(C)c(NS(=O)(=O)c2ccc(Cl)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311318	119810	18	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	309	3	1	2	4.1	Cc1cc(C)c(NS(=O)(=O)c2ccc(Cl)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	134141270	153588	0	None	3	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	334	8	1	3	4.6	CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3924759	153588	0	None	3	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	334	8	1	3	4.6	CCOc1ccc(Cl)c(-c2ccc(OCCCC(=O)O)cc2)c1	10.1016/j.bmcl.2016.10.054
	134145412	156050	0	None	2	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	330	8	1	3	4.3	O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3944507	156050	0	None	2	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	330	8	1	3	4.3	O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	134147601	156807	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3950444	156807	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	1049	7151	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	4618	7151	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	5280934	7151	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	CHEMBL8739	7151	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	DB00132	7151	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	10.1021/jm300215x
	134143899	157018	0	None	1	3	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	5	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3952316	157018	0	None	1	3	Mouse	6.5	pEC50	=	6.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	5	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	73777063	7937	39	None	1	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	8418	7937	39	None	1	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	CHEMBL3919973	7937	39	None	1	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	134152336	160235	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	408	5	1	5	4.2	Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	CHEMBL3979448	160235	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	408	5	1	5	4.2	Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	117886639	155229	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	CHEMBL3937916	155229	0	None	-1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	90417528	168951	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	513	9	1	4	7.2	CCc1ccc(-c2nsc(C(F)(F)C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4162353	168951	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	513	9	1	4	7.2	CCc1ccc(-c2nsc(C(F)(F)C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	85472359	168908	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	471	8	1	4	6.3	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4161536	168908	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	471	8	1	4	6.3	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	134148736	155333	0	None	2	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	383	8	1	4	5.4	O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3938783	155333	0	None	2	2	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	383	8	1	4	5.4	O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	134156096	158226	0	None	5	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	400	8	1	3	6.2	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3961950	158226	0	None	5	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	400	8	1	3	6.2	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	137649360	164165	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.3	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4078286	164165	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.3	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	86343961	171066	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	435	7	1	3	5.8	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c1C	10.1016/j.bmcl.2018.02.013
	CHEMBL4211967	171066	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	435	7	1	3	5.8	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c1C	10.1016/j.bmcl.2018.02.013
	145985748	172422	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	444	9	1	4	5.4	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(SCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4243863	172422	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	444	9	1	4	5.4	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(SCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	134156727	160413	0	None	-4	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3980898	160413	0	None	-4	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	134151115	158978	0	None	4	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	336	6	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3968537	158978	0	None	4	3	Mouse	7.5	pEC50	=	7.5	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	336	6	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	137631865	163113	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	399	7	1	4	5.5	Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4065769	163113	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	399	7	1	4	5.5	Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	1050	8683	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assayAgonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2018.06.047
	11595431	8683	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assayAgonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2018.06.047
	CHEMBL207881	8683	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assayAgonist activity at human GPR120 expressed in baculovirus infected sf9 cells assessed as increase in calcium flux measured every 1 sec for 60 secs by Calcium plus dye based FLIPR assay	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1016/j.bmcl.2018.06.047
	73777065	154034	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	4	1	3	5.7	CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3928591	154034	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	4	1	3	5.7	CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	134146021	155843	0	None	5	2	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	392	7	1	3	5.3	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3942922	155843	0	None	5	2	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	392	7	1	3	5.3	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)c(F)c1	10.1016/j.bmcl.2016.10.054
	73777135	157149	0	None	-5	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3953289	157149	0	None	-5	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	137643339	164822	0	None	26	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4085843	164822	0	None	26	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1	10.1016/j.bmcl.2017.01.034
	90406970	171555	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	477	7	1	3	6.2	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)c(F)c2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4218078	171555	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	477	7	1	3	6.2	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)c(F)c2)c(F)c1	10.1016/j.bmcl.2018.02.013
	134146720	155910	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	443	7	1	6	5.6	COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3943315	155910	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	443	7	1	6	5.6	COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	23136477	65604	3	None	15	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL1688455	65604	3	None	15	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL4213909	65604	3	None	15	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	134132711	151716	0	None	1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3910333	151716	0	None	1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	134145778	156126	0	None	13	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	355	3	0	3	4.3	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3945213	156126	0	None	13	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	355	3	0	3	4.3	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	137657972	166383	0	None	40	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	376	8	1	3	5.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4103243	166383	0	None	40	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	376	8	1	3	5.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	23136477	65604	3	None	15	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL1688455	65604	3	None	15	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	CHEMBL4213909	65604	3	None	15	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	332	7	1	2	5.0	O=C(O)CCc1ccc(OCc2ccccc2-c2ccccc2)cc1	10.1016/j.bmc.2017.10.040
	118707084	119787	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	321	5	1	4	3.1	COc1ccc(S(=O)(=O)Nc2c(C)cc(OC)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311198	119787	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	321	5	1	4	3.1	COc1ccc(S(=O)(=O)Nc2c(C)cc(OC)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	8190712	119811	10	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	317	5	1	2	4.4	CCCc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311319	119811	10	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	317	5	1	2	4.4	CCCc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	137643339	164822	0	None	26	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4085843	164822	0	None	26	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Cl)c1	10.1016/j.bmcl.2017.01.034
	956298	119801	9	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	319	4	1	4	2.9	COC(=O)c1cccc(NS(=O)(=O)c2ccc(C)cc2)c1C	10.1016/j.bmcl.2014.05.012
	CHEMBL3311303	119801	9	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	319	4	1	4	2.9	COC(=O)c1cccc(NS(=O)(=O)c2ccc(C)cc2)c1C	10.1016/j.bmcl.2014.05.012
	137657972	166383	0	None	40	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	376	8	1	3	5.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4103243	166383	0	None	40	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	376	8	1	3	5.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	134131874	151635	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	404	6	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3909773	151635	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	404	6	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	86281122	171105	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	453	8	1	3	5.9	CCc1ccc(-n2ccc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(F)c2F)cc1	10.1016/j.bmcl.2018.02.013
	CHEMBL4212409	171105	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	453	8	1	3	5.9	CCc1ccc(-n2ccc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(F)c2F)cc1	10.1016/j.bmcl.2018.02.013
	137660302	166217	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	413	8	1	4	5.8	CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4101135	166217	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	413	8	1	4	5.8	CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	137638176	163512	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	457	7	1	4	6.1	Cc1cc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)cc1CCC(=O)O	10.1016/j.bmcl.2017.06.028
	CHEMBL4070355	163512	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	457	7	1	4	6.1	Cc1cc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)cc1CCC(=O)O	10.1016/j.bmcl.2017.06.028
	117873187	159123	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	4	1	3	5.7	CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3969920	159123	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	4	1	3	5.7	CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	87054900	155540	0	None	1	2	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3940493	155540	0	None	1	2	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1	10.1016/j.bmcl.2016.10.054
	90418278	169158	16	None	1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4165366	169158	16	None	1	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	73777175	150687	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3901994	150687	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	60195039	88568	0	None	-181	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	377	8	2	2	5.7	CCc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	CHEMBL2164240	88568	0	None	-181	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	377	8	2	2	5.7	CCc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	134134229	150033	0	None	1	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	CHEMBL3896657	150033	0	None	1	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	134134229	150033	0	None	1	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3896657	150033	0	None	1	3	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	86281125	170850	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	445	7	1	3	5.9	OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4209308	170850	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	445	7	1	3	5.9	OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	57522038	10659	60	None	-6	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	6490	10659	60	None	-6	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	CHEMBL2058533	10659	60	None	-6	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	117886649	158857	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	391	4	1	3	5.4	OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3967504	158857	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	391	4	1	3	5.4	OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	134142866	152420	0	None	2	3	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	358	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3915765	152420	0	None	2	3	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	358	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	57521914	83046	0	None	-6	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	416	8	1	3	5.8	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(OC(F)(F)F)cc2)cc1	10.1021/jm300215x
	CHEMBL2058527	83046	0	None	-6	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	416	8	1	3	5.8	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(OC(F)(F)F)cc2)cc1	10.1021/jm300215x
	60195125	10660	8	None	-1096	3	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	9149	10660	8	None	-1096	3	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	CHEMBL2164242	10660	8	None	-1096	3	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	499	12	2	5	5.2	OC(=O)CCc1ccc(cc1F)NCc1cccc(c1)c1ccc(cc1C)OCCCS(=O)(=O)C	10.1021/jm3002026
	73777135	157149	0	None	5	2	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3953289	157149	0	None	5	2	Mouse	7.4	pEC50	=	7.4	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	73776995	155521	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	4	1	3	5.7	CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3940359	155521	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	4	1	3	5.7	CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	24825509	94721	0	None	-29	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	347	8	2	3	5.1	O=C(O)CCc1ccc(NCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/jm300215x
	CHEMBL234057	94721	0	None	-29	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	347	8	2	3	5.1	O=C(O)CCc1ccc(NCc2ccc(Oc3ccccc3)cc2)cc1	10.1021/jm300215x
	134154953	158055	0	None	7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	3	0	3	4.6	Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3960369	158055	0	None	7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assayAgonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	ChEMBL	369	3	0	3	4.6	Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	86343963	171523	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	443	7	1	3	5.5	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2cccc(F)c2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4217669	171523	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	443	7	1	3	5.5	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2cccc(F)c2)c(F)c1	10.1016/j.bmcl.2018.02.013
	134155950	157869	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	430	6	1	4	4.6	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3959068	157869	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	430	6	1	4	4.6	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	145984009	172368	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	418	7	1	4	4.7	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4242595	172368	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	418	7	1	4	4.7	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)C1	10.1016/j.bmcl.2018.06.047
	134157207	160990	0	None	3	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	386	7	1	3	5.3	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3985939	160990	0	None	3	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	386	7	1	3	5.3	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	57522038	10659	60	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/acsmedchemlett.6b00025
	6490	10659	60	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/acsmedchemlett.6b00025
	CHEMBL2058533	10659	60	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR120 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/acsmedchemlett.6b00025
	134157563	160786	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	365	6	1	4	5.0	O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl	10.1016/j.bmcl.2016.10.054
	CHEMBL3984072	160786	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	365	6	1	4	5.0	O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl	10.1016/j.bmcl.2016.10.054
	54584098	68579	5	None	-5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2cccc(Br)c2)cc1	10.1021/jm300215x
	CHEMBL1773254	68579	5	None	-5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2cccc(Br)c2)cc1	10.1021/jm300215x
	54583098	68583	0	None	-70	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2cccc(-c3ccccc3)c2)cc1	10.1021/jm300215x
	CHEMBL1773258	68583	0	None	-70	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2cccc(-c3ccccc3)c2)cc1	10.1021/jm300215x
	134157563	160786	0	None	-1	2	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	365	6	1	4	5.0	O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl	10.1016/j.bmcl.2016.10.054
	CHEMBL3984072	160786	0	None	-1	2	Mouse	6.3	pEC50	=	6.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	365	6	1	4	5.0	O=C(O)CCCOc1ccc(-c2noc3ccccc23)c(Cl)c1Cl	10.1016/j.bmcl.2016.10.054
	73777069	149447	0	None	1	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3891920	149447	0	None	1	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	134138318	154798	0	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	378	9	1	4	5.4	COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3934450	154798	0	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	378	9	1	4	5.4	COc1cccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)c1	10.1016/j.bmcl.2016.10.054
	134144000	156988	0	None	1	2	Mouse	8.3	pEC50	=	8.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3952043	156988	0	None	1	2	Mouse	8.3	pEC50	=	8.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	86281123	170527	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	439	7	1	3	5.7	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2018.02.013
	CHEMBL4205429	170527	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	439	7	1	3	5.7	Cc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2018.02.013
	137646553	164693	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	6	1	2	4.7	Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4084333	164693	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	6	1	2	4.7	Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	118707083	119786	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	325	4	1	3	3.8	COc1ccc(S(=O)(=O)Nc2c(C)cc(Cl)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311197	119786	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	325	4	1	3	3.8	COc1ccc(S(=O)(=O)Nc2c(C)cc(Cl)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	743974	119804	70	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311308	119804	70	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	137638995	163744	0	None	16	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4072885	163744	0	None	16	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F	10.1016/j.bmcl.2017.01.034
	23136401	165914	0	None	7	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	8	1	3	5.4	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4097919	165914	0	None	7	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	8	1	3	5.4	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	145984445	172239	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	456	9	1	4	5.3	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCC(C)(C)C(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4239572	172239	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	456	9	1	4	5.3	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCC(C)(C)C(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	134138281	154564	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	410	7	1	6	3.9	COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3932664	154564	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	410	7	1	6	3.9	COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	90417978	168763	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4159180	168763	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	73777153	149601	0	None	2	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3893026	149601	0	None	2	3	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	57521918	83051	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	380	7	1	2	5.9	Cc1ccc(-c2ccc(Cl)cc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	CHEMBL2058531	83051	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	380	7	1	2	5.9	Cc1ccc(-c2ccc(Cl)cc2COc2ccc(CCC(=O)O)cc2)cc1	10.1021/jm300215x
	54582150	68584	0	None	-22	2	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL1773259	68584	0	None	-22	2	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccccc2-c2ccccc2)cc1	10.1021/jm300215x
	59455584	163820	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	378	8	1	4	4.6	CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4073815	163820	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	378	8	1	4	4.6	CCc1ccc(-n2nccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	137646553	164693	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	6	1	2	4.7	Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4084333	164693	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	6	1	2	4.7	Cc1ccc(Br)c(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	134132951	151400	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	454	8	1	7	3.9	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3907996	151400	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	454	8	1	7	3.9	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	137638995	163744	0	None	16	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4072885	163744	0	None	16	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1C(F)(F)F	10.1016/j.bmcl.2017.01.034
	90407027	170973	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	437	7	1	3	6.3	Cc1c(CCCO)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2018.02.013
	CHEMBL4210752	170973	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	437	7	1	3	6.3	Cc1c(CCCO)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2018.02.013
	54585039	68577	5	None	-17	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccc(Br)cc2)cc1	10.1021/jm300215x
	CHEMBL1773252	68577	5	None	-17	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	334	6	1	2	4.0	O=C(O)CCc1ccc(OCc2ccc(Br)cc2)cc1	10.1021/jm300215x
	134143899	157018	0	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	5	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3952316	157018	0	None	-1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	5	1	3	5.0	O=C(O)CCc1cc2cc(-c3cccc(OC(F)(F)F)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	87054900	155540	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3940493	155540	0	None	-1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2ccccc2Oc2ccccc2)cc1	10.1016/j.bmcl.2016.10.054
	90406418	171356	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	457	7	1	3	5.8	CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1)C(=O)O	10.1016/j.bmcl.2018.02.013
	CHEMBL4215446	171356	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	457	7	1	3	5.8	CC(Cc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)c(F)c1)C(=O)O	10.1016/j.bmcl.2018.02.013
	134131620	149210	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	442	7	1	5	4.5	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3890035	149210	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	442	7	1	5	4.5	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	23136401	165914	0	None	7	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	8	1	3	5.4	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4097919	165914	0	None	7	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	362	8	1	3	5.4	Cc1cc(CCC(=O)O)ccc1OCc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2017.01.034
	90418513	169402	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	429	8	1	4	6.2	CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4169436	169402	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	429	8	1	4	6.2	CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	23136363	65607	0	None	-14	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1021/jm300215x
	CHEMBL1688458	65607	0	None	-14	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1021/jm300215x
	134150245	159024	0	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	5.1	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3968947	159024	0	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	5.1	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	137643146	164843	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	455	8	1	4	5.8	CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4086174	164843	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	455	8	1	4	5.8	CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	73777085	160009	0	None	1	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3977361	160009	0	None	1	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	73776997	161059	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	407	4	1	4	4.5	O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3986483	161059	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	407	4	1	4	4.5	O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1	10.1021/acsmedchemlett.6b00360
	23346507	95063	1	None	-30	2	Human	4.2	pEC50	=	4.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	255	6	2	2	3.3	O=C(O)CCc1ccc(NCc2ccccc2)cc1	10.1021/jm300215x
	CHEMBL234834	95063	1	None	-30	2	Human	4.2	pEC50	=	4.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	255	6	2	2	3.3	O=C(O)CCc1ccc(NCc2ccccc2)cc1	10.1021/jm300215x
	57521810	83040	0	None	1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(F)cc2)cc1	10.1021/jm300215x
	CHEMBL2058521	83040	0	None	1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	350	7	1	2	5.1	O=C(O)CCc1ccc(OCc2ccccc2-c2ccc(F)cc2)cc1	10.1021/jm300215x
	24825484	94766	0	None	-208	2	Human	4.2	pEC50	=	4.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1	10.1021/jm300215x
	CHEMBL234269	94766	0	None	-208	2	Human	4.2	pEC50	=	4.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	331	7	2	2	5.0	O=C(O)CCc1ccc(NCc2ccc(-c3ccccc3)cc2)cc1	10.1021/jm300215x
	73777111	156489	0	None	1	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3947837	156489	0	None	1	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	137642184	165281	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	2	4	4.4	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4091118	165281	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	2	4	4.4	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1	10.1016/j.bmcl.2017.01.034
	134156727	160413	0	None	4	2	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3980898	160413	0	None	4	2	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	137637576	162842	0	None	63	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	298	6	1	2	4.2	Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4062640	162842	0	None	63	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	298	6	1	2	4.2	Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	137658634	166182	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4100773	166182	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1	10.1016/j.bmcl.2017.01.034
	137643146	164843	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	455	8	1	4	5.8	CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4086174	164843	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	455	8	1	4	5.8	CCc1ccc(-c2noc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1016/j.bmcl.2017.06.028
	134144214	157137	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	8	1	3	5.7	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3953203	157137	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	384	8	1	3	5.7	O=C(O)CCCOc1ccc(-c2cc(Oc3cccc(F)c3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	59455552	162820	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	384	7	1	4	4.7	Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4062462	162820	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	384	7	1	4	4.7	Cc1c(CCC(=O)O)ccc(OCc2ccnn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	134134229	150033	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	CHEMBL3896657	150033	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	134134229	150033	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3896657	150033	0	None	-1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	137637576	162842	0	None	63	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	298	6	1	2	4.2	Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4062640	162842	0	None	63	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	298	6	1	2	4.2	Cc1cc(C)cc(COc2ccc(CCC(=O)O)cc2C)c1	10.1016/j.bmcl.2017.01.034
	137658634	166182	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4100773	166182	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	342	8	1	3	4.7	Cc1cc(COc2ccc(CCC(=O)O)cc2C)cc(OC(C)C)c1	10.1016/j.bmcl.2017.01.034
	57522038	10659	60	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	6490	10659	60	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	CHEMBL2058533	10659	60	None	-6	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	137638911	163508	0	None	32	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4070298	163508	0	None	32	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	137656526	166532	0	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	356	7	1	3	4.9	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4105013	166532	0	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	356	7	1	3	4.9	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	743974	119804	70	None	-3	3	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at mouse FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311308	119804	70	None	-3	3	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at mouse FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	46941175	68586	26	None	-331	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm3002026
	CHEMBL1773261	68586	26	None	-331	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm3002026
	46941175	68586	26	None	-331	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	CHEMBL1773261	68586	26	None	-331	3	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	345	7	2	2	5.3	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	3518281	119809	11	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	293	3	1	2	3.6	Cc1cc(C)c(NS(=O)(=O)c2ccc(F)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311317	119809	11	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	293	3	1	2	3.6	Cc1cc(C)c(NS(=O)(=O)c2ccc(F)cc2)c(C)c1	10.1016/j.bmcl.2014.05.012
	137642184	165281	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	2	4	4.4	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4091118	165281	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	386	8	2	4	4.4	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)c(CO)c1	10.1016/j.bmcl.2017.01.034
	145985122	172687	0	None	17	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	456	11	1	4	5.5	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4250132	172687	0	None	17	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	456	11	1	4	5.5	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	134147174	156482	0	None	2	2	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	6	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3947787	156482	0	None	2	2	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	6	1	3	5.7	O=C(O)CCc1cc2cc(-c3cc(Cl)cc(OC4CCC4)c3)ccc2o1	10.1016/j.bmcl.2016.10.054
	134145412	156050	0	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	330	8	1	3	4.3	O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3944507	156050	0	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	330	8	1	3	4.3	O=C(O)CCCOc1ccc(-c2cc(OC3CC3)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	73777156	159494	0	None	1	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3973034	159494	0	None	1	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	134143163	152522	0	None	2	2	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	362	8	1	3	5.7	Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3916564	152522	0	None	2	2	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	362	8	1	3	5.7	Cc1ccc(Oc2cccc(-c3ccc(OCCCC(=O)O)cc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	137638911	163508	0	None	32	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4070298	163508	0	None	32	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	384	7	1	3	5.5	Cc1cc(CCC(=O)O)cc(C)c1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	134134149	150153	0	None	2	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3897776	150153	0	None	2	3	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	348	8	1	3	5.4	O=C(O)CCCOc1ccc(-c2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2016.10.054
	137640328	163763	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F	10.1016/j.bmcl.2017.06.028
	CHEMBL4073078	163763	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1F	10.1016/j.bmcl.2017.06.028
	117886639	155229	0	None	1	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	CHEMBL3937916	155229	0	None	1	2	Mouse	6.2	pEC50	=	6.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	118184919	169652	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	468	7	1	5	5.6	N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4173280	169652	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	468	7	1	5	5.6	N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	54586984	68581	0	None	-34	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	323	6	2	2	4.3	O=C(O)CCc1ccc(NCc2cccc(C(F)(F)F)c2)cc1	10.1021/jm300215x
	CHEMBL1773256	68581	0	None	-34	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	323	6	2	2	4.3	O=C(O)CCc1ccc(NCc2cccc(C(F)(F)F)c2)cc1	10.1021/jm300215x
	134139171	153041	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	6	1	3	5.4	Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1	10.1016/j.bmcl.2016.10.054
	CHEMBL3920591	153041	0	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	350	6	1	3	5.4	Cc1cc(OC2CCC2)cc(-c2ccc3oc(CCC(=O)O)cc3c2)c1	10.1016/j.bmcl.2016.10.054
	137661886	166106	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	453	7	1	4	6.2	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4099943	166106	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	453	7	1	4	6.2	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c1C	10.1016/j.bmcl.2017.06.028
	90418886	169699	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	423	9	1	4	6.1	CCc1ccc(-c2nsc(CC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4174122	169699	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	423	9	1	4	6.1	CCc1ccc(-c2nsc(CC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	137656526	166532	0	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	356	7	1	3	4.9	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4105013	166532	0	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	356	7	1	3	4.9	O=C(O)CCc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	145985686	172209	0	None	354	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	358	7	1	3	4.2	COc1cc(F)c(F)c(-c2cc(F)c(OCCCC(=O)O)c(F)c2)c1	10.1016/j.bmcl.2018.06.047
	CHEMBL4238809	172209	0	None	354	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	358	7	1	3	4.2	COc1cc(F)c(F)c(-c2cc(F)c(OCCCC(=O)O)c(F)c2)c1	10.1016/j.bmcl.2018.06.047
	137648785	164389	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	427	7	1	4	5.2	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4080995	164389	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	427	7	1	4	5.2	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	134153986	159285	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3971308	159285	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134153562	159502	0	None	2	3	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	394	7	1	3	4.9	O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F	10.1016/j.bmcl.2016.10.054
	CHEMBL3973101	159502	0	None	2	3	Mouse	8.2	pEC50	=	8.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	394	7	1	3	4.9	O=C(O)CCCOc1c(F)cc(-c2cc(OC(F)(F)F)ccc2F)cc1F	10.1016/j.bmcl.2016.10.054
	134140073	153099	0	None	1	2	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.4	CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3921062	153099	0	None	1	2	Mouse	7.2	pEC50	=	7.2	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.4	CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O	10.1016/j.bmcl.2016.10.054
	134135468	151253	0	None	1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	389	4	1	3	4.8	O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3906716	151253	0	None	1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	389	4	1	3	4.8	O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1	10.1021/acsmedchemlett.6b00360
	57521702	83037	0	None	-11	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1ccccc1COc1ccc(CCC(=O)O)cc1	10.1021/jm300215x
	CHEMBL2058518	83037	0	None	-11	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1ccccc1COc1ccc(CCC(=O)O)cc1	10.1021/jm300215x
	137636575	162680	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	479	7	1	4	6.0	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4060663	162680	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	479	7	1	4	6.0	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(F)cc3Cl)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	137635671	162770	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	CHEMBL4061699	162770	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	461	7	1	4	5.9	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)noc2C(F)(F)F)c(F)c1	10.1016/j.bmcl.2017.06.028
	85471695	165448	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4092882	165448	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2cscc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	85470884	170783	2	None	-7	5	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant rat GPR120 expressed in HEK293 cellsAgonist activity at recombinant rat GPR120 expressed in HEK293 cells	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4208325	170783	2	None	-7	5	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant rat GPR120 expressed in HEK293 cellsAgonist activity at recombinant rat GPR120 expressed in HEK293 cells	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	134155847	157881	0	None	63	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	418	5	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3959144	157881	0	None	63	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	418	5	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134132711	151716	0	None	-1	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3910333	151716	0	None	-1	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	137636167	162766	0	None	2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O	10.1016/j.bmcl.2017.01.034
	CHEMBL4061630	162766	0	None	2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O	10.1016/j.bmcl.2017.01.034
	134142450	152224	0	None	10	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.7	CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3914253	152224	0	None	10	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.7	CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	137660302	166217	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	413	8	1	4	5.8	CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4101135	166217	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	413	8	1	4	5.8	CCc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	90418333	169434	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	473	8	1	5	5.7	COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4169851	169434	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	473	8	1	5	5.7	COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	57522038	10659	60	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	6490	10659	60	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	CHEMBL2058533	10659	60	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmc.2017.10.040
	57839754	164595	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	270	6	1	2	3.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4083325	164595	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	270	6	1	2	3.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2017.01.034
	90407037	164067	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	377	8	1	3	5.3	CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4076902	164067	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	377	8	1	3	5.3	CCc1ccc(-n2cccc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	3893	9067	98	None	-10	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	4642	9067	98	None	-10	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	5534	9067	98	None	-10	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	CHEMBL108766	9067	98	None	-10	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	DB03017	9067	98	None	-10	4	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assayAgonist activity at N-terminal FLAG-tagged/C-terminal eYFP-fused human FFA4 receptor expressed in HEK293T cells assessed as induction of beta-arrestin-2 recruitment after 5 mins by BRET assay	ChEMBL	200	10	1	1	4.0	CCCCCCCCCCCC(=O)O	10.1039/C7MD00130D
	59455555	165495	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	399	7	1	4	5.5	Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4093383	165495	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	399	7	1	4	5.5	Cc1onc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	134149615	155355	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	CHEMBL3939004	155355	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	370	5	1	3	4.6	O=C(O)CCC1Cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1016/j.bmcl.2016.10.054
	90418278	169158	16	None	-1	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 by calcium flux assayAgonist activity at mouse GPR120 by calcium flux assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4165366	169158	16	None	-1	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 by calcium flux assayAgonist activity at mouse GPR120 by calcium flux assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	134155277	158104	0	None	3	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl	10.1016/j.bmcl.2016.10.054
	CHEMBL3961009	158104	0	None	3	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	388	7	1	3	5.5	Cc1cc(OCCCC(=O)O)ccc1-c1cc(OC(F)(F)F)ccc1Cl	10.1016/j.bmcl.2016.10.054
	134133992	150517	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3900705	150517	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as increase in IP1 accumulation after 60 mins by HTRF assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134133297	150557	0	None	3	3	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	372	7	1	3	4.9	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3900990	150557	0	None	3	3	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	372	7	1	3	4.9	Cc1cc(-c2cc(OC(F)(F)F)ccc2F)ccc1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	977153	58194	15	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	339	4	1	3	4.1	COc1cc(S(=O)(=O)Nc2c(C)cc(C)cc2C)ccc1Cl	10.1016/j.bmcl.2014.05.012
	CHEMBL1581959	58194	15	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	339	4	1	3	4.1	COc1cc(S(=O)(=O)Nc2c(C)cc(C)cc2C)ccc1Cl	10.1016/j.bmcl.2014.05.012
	137636167	162766	0	None	2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O	10.1016/j.bmcl.2017.01.034
	CHEMBL4061630	162766	0	None	2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	370	7	1	3	5.2	Cc1cc(OCc2ccccc2SC(F)(F)F)ccc1CCC(=O)O	10.1016/j.bmcl.2017.01.034
	57839754	164595	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	270	6	1	2	3.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4083325	164595	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	270	6	1	2	3.6	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2017.01.034
	743974	119804	70	None	-1	3	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at rat FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311308	119804	70	None	-1	3	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity at rat FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at rat FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	8190702	119808	2	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	317	4	1	3	3.6	CC(=O)c1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311316	119808	2	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPRAgonist activity at human FFA4 receptor expressed in U2OS cells assessed as calcium mobilization after 24 hrs by FLIPR	ChEMBL	317	4	1	3	3.6	CC(=O)c1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	85470884	170783	2	None	2	5	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4208325	170783	2	None	2	5	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	137634829	162851	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2scnc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4062742	162851	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux by Fluo-4 NW dye based FLIPR assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2scnc2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	134154417	159483	0	None	2	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3972973	159483	0	None	2	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(-[n+]3ccsc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	137631865	163113	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	399	7	1	4	5.5	Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4065769	163113	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	399	7	1	4	5.5	Cc1noc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1016/j.bmcl.2017.06.028
	134145750	155924	0	None	-3	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	324	6	1	2	4.6	O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3943430	155924	0	None	-3	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	324	6	1	2	4.6	O=C(O)CCCOc1ccc(-c2ccccc2C(F)(F)F)cc1	10.1016/j.bmcl.2016.10.054
	134142450	152224	0	None	-10	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.7	CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3914253	152224	0	None	-10	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.7	CC(CC(=O)O)c1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	134140073	153099	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.4	CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3921062	153099	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	382	5	1	3	5.4	CC(Cc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1)C(=O)O	10.1016/j.bmcl.2016.10.054
	46892131	151449	2	None	3	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3908362	151449	2	None	3	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assayAgonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	51350138	65623	0	None	-660	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	CHEMBL1688473	65623	0	None	-660	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	378	7	1	2	5.7	Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	86343792	171460	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	475	7	1	3	6.3	O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2018.02.013
	CHEMBL4216937	171460	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	475	7	1	3	6.3	O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2018.02.013
	60195038	88567	0	None	-912	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	363	7	2	2	5.4	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	CHEMBL2164239	88567	0	None	-912	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	363	7	2	2	5.4	Cc1ccccc1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	85472487	169256	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4167097	169256	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	51350272	65615	0	None	-107	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	CHEMBL1688465	65615	0	None	-107	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	346	7	1	2	5.3	Cc1ccccc1-c1cccc(COc2ccc(CCC(=O)O)cc2)c1	10.1021/jm300215x
	145985219	172243	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	420	9	1	4	5.0	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(C)c(OCCCC(=O)O)c(C)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4239630	172243	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	420	9	1	4	5.0	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(C)c(OCCCC(=O)O)c(C)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	90406893	171214	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	454	8	1	4	5.3	CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1	10.1016/j.bmcl.2018.02.013
	CHEMBL4213710	171214	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	454	8	1	4	5.3	CCc1ccc(-n2ccc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cn1	10.1016/j.bmcl.2018.02.013
	134148736	155333	0	None	-2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	383	8	1	4	5.4	O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3938783	155333	0	None	-2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	383	8	1	4	5.4	O=C(O)CCCOc1ccc(-c2cc(Oc3cccnc3)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	86281121	170791	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	451	7	1	3	6.4	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2018.02.013
	CHEMBL4208442	170791	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	451	7	1	3	6.4	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2018.02.013
	134138802	154697	0	None	4	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3933619	154697	0	None	4	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse GPR120 assessed as induction of IP1 accumulationAgonist activity at mouse GPR120 assessed as induction of IP1 accumulation	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	137649416	164298	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2017.01.034
	CHEMBL4079893	164298	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	338	6	1	2	4.6	Cc1cc(CCC(=O)O)ccc1OCc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2017.01.034
	134150245	159024	0	None	6	3	Mouse	8.1	pEC50	=	8.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	5.1	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3968947	159024	0	None	6	3	Mouse	8.1	pEC50	=	8.1	Functional	Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	374	7	1	3	5.1	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2Cl)cc1	10.1016/j.bmcl.2016.10.054
	137657968	166371	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	CHEMBL4103081	166371	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	394	8	1	3	6.2	CCc1ccc(-c2ccsc2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1016/j.bmcl.2017.06.028
	90407263	170378	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F	10.1016/j.bmcl.2018.02.013
	CHEMBL4203559	170378	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1F	10.1016/j.bmcl.2018.02.013
	57521917	83050	0	None	-8	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2ccc(Cl)cc2-c2ccccc2)cc1	10.1021/jm300215x
	CHEMBL2058530	83050	0	None	-8	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assayAgonist activity at GPR120 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 5 mins by BRET assay	ChEMBL	366	7	1	2	5.6	O=C(O)CCc1ccc(OCc2ccc(Cl)cc2-c2ccccc2)cc1	10.1021/jm300215x
	90418067	169110	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	425	9	1	5	5.6	CCc1ccc(-c2nsc(OC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4164722	169110	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	425	9	1	5	5.6	CCc1ccc(-c2nsc(OC)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	86343790	170718	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	441	7	1	3	5.9	O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1Cl	10.1016/j.bmcl.2018.02.013
	CHEMBL4207603	170718	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assayAgonist activity at recombinant human GPR120 short isoform expressed in HEK293 cells assessed as intracellular calcium flux measured for 300 secs at 1 sec time interval by Fluo-4 NW based FLIPR assay	ChEMBL	441	7	1	3	5.9	O=C(O)CCc1ccc(OCc2c(C(F)(F)F)ccn2-c2ccc(F)cc2)cc1Cl	10.1016/j.bmcl.2018.02.013
	145984796	172521	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	428	9	1	4	4.7	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	CHEMBL4246396	172521	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assayAgonist activity at human GPR120 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo-4-AM dye based assay	ChEMBL	428	9	1	4	4.7	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3cc(F)c(OCCCC(=O)O)c(F)c3)c2)C1	10.1016/j.bmcl.2018.06.047
	90405989	162739	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	383	7	1	3	5.3	Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	CHEMBL4061340	162739	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as increase in intracellular calcium flux by DiscoveRx PathHunter beta-arrestin assay	ChEMBL	383	7	1	3	5.3	Cc1c(CCC(=O)O)ccc(OCc2cccn2-c2ccc(Cl)cc2)c1C	10.1016/j.bmcl.2017.06.028
	60195040	88569	0	None	-5248	2	Human	4.0	pEC50	=	4.0	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	377	7	2	2	5.7	Cc1cccc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	CHEMBL2164241	88569	0	None	-5248	2	Human	4.0	pEC50	=	4.0	Functional	Agonist activity at GPR120 assessed as stimulation of calcium mobilizationAgonist activity at GPR120 assessed as stimulation of calcium mobilization	ChEMBL	377	7	2	2	5.7	Cc1cccc(C)c1-c1cccc(CNc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/jm3002026
	134132142	151647	0	None	-13	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	CHEMBL3909872	151647	0	None	-13	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 assessed as induction of IP1 accumulationAgonist activity at human GPR120 assessed as induction of IP1 accumulation	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	134132142	151647	0	None	-13	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	CHEMBL3909872	151647	0	None	-13	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1016/j.bmcl.2016.10.054
	145971522	169895	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL4177287	169895	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	134142866	152420	0	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	358	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	CHEMBL3915765	152420	0	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	358	7	1	3	4.6	O=C(O)CCCOc1ccc(-c2cc(OC(F)(F)F)ccc2F)cc1	10.1016/j.bmcl.2016.10.054
	57522038	10659	60	None	-6	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assayAgonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	6490	10659	60	None	-6	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assayAgonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	CHEMBL2058533	10659	60	None	-6	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assayAgonist activity at GPR120 expressed in Flp-In TREx293 cells by calcium assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1021/jm300215x
	137634844	162895	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	412	9	1	3	6.1	CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	CHEMBL4063239	162895	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	412	9	1	3	6.1	CC(C)Cc1cc(CCC(=O)O)ccc1OCc1ccccc1SC(F)(F)F	10.1016/j.bmcl.2017.01.034
	23136363	65607	0	None	-14	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL1688458	65607	0	None	-14	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	348	8	1	3	5.1	O=C(O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1	10.1016/j.bmcl.2017.01.034
	134141029	153945	0	None	-4	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	352	6	1	3	4.8	O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	CHEMBL3927879	153945	0	None	-4	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayAgonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assay	ChEMBL	352	6	1	3	4.8	O=C(O)CCc1cc2cc(-c3cc(C(=O)C4CC4)ccc3F)ccc2o1	10.1016/j.bmcl.2016.10.054
	82051616	166236	1	None	12	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl	10.1016/j.bmcl.2017.01.034
	CHEMBL4101323	166236	1	None	12	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	304	6	1	2	4.2	Cc1cc(CCC(=O)O)ccc1OCc1ccccc1Cl	10.1016/j.bmcl.2017.01.034
	73777063	7937	39	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	8418	7937	39	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	CHEMBL3919973	7937	39	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	85472618	169089	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	491	7	1	4	6.7	Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4164509	169089	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assayAgonist activity at human GPR120 short splice variant expressed in HEK293 cells assessed as increase in intracellular calcium flux incubated for 30 mins measured for 300 secs at 1 sec interval by Fluo-4 NW dye based FLIPR assay	ChEMBL	491	7	1	4	6.7	Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F	10.1021/acsmedchemlett.7b00233
	137640323	163757	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	358	7	1	4	4.3	O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	CHEMBL4073013	163757	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assayAgonist activity at human FFA4 receptor expressed in human U2OS cells co-expressing Galpha16 assessed as calcium mobilization by Fluo-4 dye based FLIPR assay	ChEMBL	358	7	1	4	4.3	O=C(O)COc1ccc(OCc2ccccc2SC(F)(F)F)cc1	10.1016/j.bmcl.2017.01.034
	5588	8642	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	372	9	3	3	6.1	C/C(=C\Cc1c(O)cc(c(c1O)C(=O)O)C)/CC/C=C(/CCC=C(C)C)\C	19471906
	9976563	8642	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	372	9	3	3	6.1	C/C(=C\Cc1c(O)cc(c(c1O)C(=O)O)C)/CC/C=C(/CCC=C(C)C)\C	19471906
	CHEMBL513978	8642	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	372	9	3	3	6.1	C/C(=C\Cc1c(O)cc(c(c1O)C(=O)O)C)/CC/C=C(/CCC=C(C)C)\C	19471906
	11531145	8643	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	386	10	2	3	6.4	COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O	19471906
	11531145	8643	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	386	10	2	3	6.4	COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O	20685848
	5589	8643	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	386	10	2	3	6.4	COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O	19471906
	5589	8643	0	None	-	1	Human	5.0	pA2	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	386	10	2	3	6.4	COc1cc(C)c(c(c1C/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)O)C(=O)O	20685848
	1054	9691	85	None	-1	5	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	None
	3400	9691	85	None	-1	5	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	None
	445639	9691	85	None	-1	5	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	None
	CHEMBL8659	9691	85	None	-1	5	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	None
	1052	9101	85	None	3	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	3323	9101	85	None	3	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	5280450	9101	85	None	3	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	CHEMBL267476	9101	85	None	3	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	DB14104	9101	85	None	3	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	None
	11195	10654	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.	Guide to Pharmacology	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	27570890
	86280676	10654	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.	Guide to Pharmacology	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	27570890
	CHEMBL3941880	10654	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.	Guide to Pharmacology	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	27570890
	11195	10654	0	None	-1	2	Mouse	6.8	pEC50	=	6.8	Functional	Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.	Guide to Pharmacology	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	27570890
	86280676	10654	0	None	-1	2	Mouse	6.8	pEC50	=	6.8	Functional	Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.	Guide to Pharmacology	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	27570890
	CHEMBL3941880	10654	0	None	-1	2	Mouse	6.8	pEC50	=	6.8	Functional	Determined in a Ca2+ mobilization assay.Determined in a Ca2+ mobilization assay.	Guide to Pharmacology	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	27570890
	73777063	7937	39	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Fluorometric calcium assay using FLIPR methodology.Fluorometric calcium assay using FLIPR methodology.	Guide to Pharmacology	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	24997608
	8418	7937	39	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Fluorometric calcium assay using FLIPR methodology.Fluorometric calcium assay using FLIPR methodology.	Guide to Pharmacology	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	24997608
	CHEMBL3919973	7937	39	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Fluorometric calcium assay using FLIPR methodology.Fluorometric calcium assay using FLIPR methodology.	Guide to Pharmacology	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	24997608
	1054	9691	85	None	-1	5	Human	4.7	pEC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	22282525
	3400	9691	85	None	-1	5	Human	4.7	pEC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	22282525
	445639	9691	85	None	-1	5	Human	4.7	pEC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	22282525
	CHEMBL8659	9691	85	None	-1	5	Human	4.7	pEC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	282	15	1	1	6.1	CCCCCCCC/C=C\CCCCCCCC(=O)O	22282525
	1049	7151	75	None	-4	3	Rat	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	18320172
	4618	7151	75	None	-4	3	Rat	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	18320172
	5280934	7151	75	None	-4	3	Rat	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	18320172
	CHEMBL8739	7151	75	None	-4	3	Rat	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	18320172
	DB00132	7151	75	None	-4	3	Rat	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	18320172
	11005	9471	107	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	22282525
	2806	9471	107	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	22282525
	CHEMBL111077	9471	107	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	22282525
	DB08231	9471	107	None	1	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	228	12	1	1	4.8	CCCCCCCCCCCCCC(=O)O	22282525
	1050	8683	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	16702987
	1050	8683	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	18827341
	11595431	8683	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	16702987
	11595431	8683	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	18827341
	CHEMBL207881	8683	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	16702987
	CHEMBL207881	8683	94	None	-26	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	18827341
	1049	7151	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	22519963
	4618	7151	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	22519963
	5280934	7151	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	22519963
	CHEMBL8739	7151	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	22519963
	DB00132	7151	75	None	-1	3	Human	5.5	pEC50	=	5.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	278	13	1	1	5.7	CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O	22519963
	1052	9101	85	None	3	4	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	16702987
	3323	9101	85	None	3	4	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	16702987
	5280450	9101	85	None	3	4	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	16702987
	CHEMBL267476	9101	85	None	3	4	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	16702987
	DB14104	9101	85	None	3	4	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	280	14	1	1	5.9	CCCCC/C=C\C/C=C\CCCCCCCC(=O)O	16702987
	25098573	9523	8	None	8	2	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	19007110
	5587	9523	8	None	8	2	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	19007110
	CHEMBL463785	9523	8	None	8	2	Human	5.9	pEC50	=	5.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	376	10	1	4	4.7	OC(=O)CCCc1ccc(cc1)OCCN(c1ccccn1)c1ccccc1	19007110

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	134154473	159153	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	370	6	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3970238	159153	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	370	6	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	73776979	150137	0	None	-	0	Human	6.0	pEC50	=	6	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	5	1	3	5.9	O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3897637	150137	0	None	-	0	Human	6.0	pEC50	=	6	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	5	1	3	5.9	O=C(O)CCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	137638318	163513	0	None	-	1	Mouse	6.0	pEC50	=	6	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	402	4	1	5	4.4	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4070359	163513	0	None	-	1	Mouse	6.0	pEC50	=	6	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	402	4	1	5	4.4	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1	10.1021/acs.jmedchem.7b00210
	CHEMBL5266523	200264	0	None	-	0	Human	5.0	pEC50	=	5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	484	10	2	8	3.7	Cc1cc(OCc2nc(N)nc(NCCc3cccc(OC(F)F)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	CHEMBL5269688	200384	0	None	-	0	Human	5.0	pEC50	=	5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.1	Cc1cc(OCc2nc(N)nc(NCCc3cccc(C(F)(F)F)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	CHEMBL5278791	200775	0	None	-	0	Human	5.0	pEC50	=	5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.1	Cc1cc(OCc2nc(N)nc(NCCc3ccccc3C(F)(F)F)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	CHEMBL5283726	201006	0	None	-	0	Human	5.0	pEC50	=	5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	466	8	2	7	4.3	Cc1cc(OCc2nc(N)nc(NCC(C)c3cccc(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	127031569	145962	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	264	4	1	1	3.3	O=C(O)CCc1ccc(C#CCc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3787580	145962	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	264	4	1	1	3.3	O=C(O)CCc1ccc(C#CCc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
	145971522	169895	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL4177287	169895	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(C(F)(F)F)nsc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	134129938	149218	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	414	6	1	4	5.0	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3890089	149218	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	414	6	1	4	5.0	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	156011529	184176	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	420	7	1	3	6.2	CCc1cc2cc(C(F)(F)F)cc(COc3ccc(CCC(=O)O)c(C)c3C)c2o1	10.1016/j.bmc.2019.115263
	CHEMBL4638249	184176	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	420	7	1	3	6.2	CCc1cc2cc(C(F)(F)F)cc(COc3ccc(CCC(=O)O)c(C)c3C)c2o1	10.1016/j.bmc.2019.115263
	134132142	151647	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	CHEMBL3909872	151647	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	73777175	150687	0	None	-	0	Mouse	6.0	pEC50	=	6.0	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3901994	150687	0	None	-	0	Mouse	6.0	pEC50	=	6.0	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	85472621	169582	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4172392	169582	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	66562488	97146	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	336	4	1	1	4.3	O=C(O)CCc1ccc(C#Cc2cc(F)ccc2C(F)F)cc1F	10.1021/ml4000673
	CHEMBL2386364	97146	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	336	4	1	1	4.3	O=C(O)CCc1ccc(C#Cc2cc(F)ccc2C(F)F)cc1F	10.1021/ml4000673
	CHEMBL5274344	200589	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	492	6	2	7	4.9	Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3C(F)(F)F)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
	CHEMBL5286838	201138	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as calcium accumulationAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as calcium accumulation	ChEMBL	362	3	0	4	3.6	C#Cc1cc(Oc2cccnc2)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.0c01002
	73777153	149601	0	None	-	0	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3893026	149601	0	None	-	0	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL5276740	200692	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	417	6	2	8	4.3	Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(C(C)C)cc4)n3)ccc12	10.1021/acsmedchemlett.2c00160
	CHEMBL5281423	200890	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	442	6	2	7	4.0	Cc1ccc(Nc2nc(N)nc(COc3cc(F)cc(N4CCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
	CHEMBL5288340	201196	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	482	9	2	8	3.9	COC(CNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1)c1cccc(Cl)c1	10.1021/acsmedchemlett.2c00160
	137640163	163627	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	372	5	1	5	4.4	Cc1nn(-c2ccccn2)c2cc(-c3ccc(C(C)CC(=O)O)cc3)ncc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4071523	163627	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	372	5	1	5	4.4	Cc1nn(-c2ccccn2)c2cc(-c3ccc(C(C)CC(=O)O)cc3)ncc12	10.1021/acs.jmedchem.7b00210
	CHEMBL5284985	201053	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	389	5	2	8	3.5	Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1	10.1021/acsmedchemlett.2c00160
	11195	10654	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	86280676	10654	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	CHEMBL3941880	10654	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	CHEMBL5275980	200660	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR120 expressed in HEK293 cells by beta-arrestin assayAgonist activity at human GPR120 expressed in HEK293 cells by beta-arrestin assay	ChEMBL	462	7	1	3	6.9	OCCCc1c(F)cc(OCc2c(-c3ccc(Cl)cc3)csc2C(F)(F)F)cc1F	10.1021/acs.jmedchem.0c01002
	134153222	159304	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3971461	159304	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccncc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL5286544	201129	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	457	5	2	8	4.8	Cc1c(Cl)cc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
	11195	10654	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	86280676	10654	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	CHEMBL3941880	10654	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	145955668	169204	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	415	7	1	4	6.0	Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL4166208	169204	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	415	7	1	4	6.0	Cc1snc(-c2ccc(Cl)cc2)c1COc1ccc(CCC(=O)O)c(C)c1C	10.1021/acsmedchemlett.7b00233
	162644046	188589	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	361	4	2	5	3.0	Nc1ccc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	CHEMBL4778107	188589	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	361	4	2	5	3.0	Nc1ccc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	134146720	155910	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	443	7	1	6	5.6	COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3943315	155910	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	443	7	1	6	5.6	COc1cc(Oc2ncc(C)s2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	134146958	156388	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	388	6	1	3	5.1	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3947070	156388	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	388	6	1	3	5.1	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(F)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134147601	156807	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3950444	156807	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@H]1C[C@@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	90418139	169360	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	443	7	1	4	5.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4168786	169360	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	443	7	1	4	5.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccccc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL5272492	200506	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	403	6	2	8	3.8	CCc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(C)cc4)n3)ccc12	10.1021/acsmedchemlett.2c00160
	90418650	164134	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL4077787	164134	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	401	7	1	4	5.7	Cc1c(CCC(=O)O)ccc(OCc2csnc2-c2ccc(Cl)cc2)c1C	10.1021/acsmedchemlett.7b00233
	134132711	151716	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3910333	151716	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	73345869	97137	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	321	5	1	2	3.7	N#CCCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	CHEMBL2386355	97137	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	321	5	1	2	3.7	N#CCCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	CHEMBL5281020	200875	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	442	6	2	7	4.0	Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3F)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
	134133992	150517	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3900705	150517	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cnc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	73777135	157149	0	None	-	0	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3953289	157149	0	None	-	0	Mouse	6.9	pEC50	=	6.9	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	73777175	150687	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3901994	150687	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	357	3	1	2	4.9	O=C(O)CC1CCC2(CC1)CCN(c1cc(F)cc(Cl)c1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL5287358	201160	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	448	9	2	8	3.1	COc1ccccc1CCNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1	10.1021/acsmedchemlett.2c00160
	CHEMBL5288405	201202	0	None	-	0	Human	4.9	pEC50	=	4.9	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	448	9	2	8	3.1	COc1cccc(CCNc2nc(N)nc(COc3cc(C)cc(N4CCCC4=O)c3)n2)c1	10.1021/acsmedchemlett.2c00160
	90418653	144291	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C	10.1021/acsmedchemlett.7b00233
	CHEMBL3754160	144291	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	469	7	1	4	6.7	Cc1c(CCC(=O)O)ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1C	10.1021/acsmedchemlett.7b00233
	90418278	169158	16	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4165366	169158	16	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3F)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL5283217	200970	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	449	6	2	8	3.7	Cc1ccc(Nc2nc(N)nc(COc3cc(C#N)cc(N4CCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
	CHEMBL5277986	200740	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	438	6	2	7	4.2	Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCC4=O)c3C)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
	25150014	10657	55	None	-	1	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/ml4000673
	3952	10657	55	None	-	1	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/ml4000673
	CHEMBL449588	10657	55	None	-	1	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	264	3	1	1	3.4	OC(=O)CCc1ccc(cc1)C#Cc1ccccc1C	10.1021/ml4000673
	CHEMBL5266881	200279	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	458	6	2	7	4.5	Cc1ccc(Nc2nc(N)nc(COc3cc(Cl)cc(N4CCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
	CHEMBL5290885	201296	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	423	5	2	8	4.2	Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
	134151903	160135	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	438	6	1	6	4.2	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3978465	160135	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	438	6	1	6	4.2	COc1cc(OC(F)(F)F)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	134133797	150346	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	338	3	0	4	3.6	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3899190	150346	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	338	3	0	4	3.6	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	162674347	189900	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	364	7	1	2	5.4	Cc1ccc(-c2ccc(F)cc2OCc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4794951	189900	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	364	7	1	2	5.4	Cc1ccc(-c2ccc(F)cc2OCc2ccc(CCC(=O)O)cc2)cc1	10.1016/j.bmcl.2020.127650
	90418651	169192	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	469	8	1	4	6.6	CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	CHEMBL4166012	169192	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	469	8	1	4	6.6	CCc1cc(CCC(=O)O)ccc1OCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	CHEMBL5289099	201239	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	425	6	2	8	4.1	Cc1ccc(Nc2nc(N)nc(COc3ccc4c(C(F)F)cc(=O)oc4c3)n2)cc1	10.1021/acsmedchemlett.2c00160
	57522038	10659	60	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmcl.2020.127650
	6490	10659	60	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmcl.2020.127650
	CHEMBL2058533	10659	60	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	364	7	1	2	5.4	OC(=O)CCc1ccc(cc1)OCc1cc(F)ccc1c1ccc(cc1)C	10.1016/j.bmcl.2020.127650
	66562385	97143	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	282	3	1	1	3.6	Cc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	CHEMBL2386361	97143	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	282	3	1	1	3.6	Cc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	134134229	150033	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	CHEMBL3896657	150033	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	134138802	154697	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3933619	154697	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at human GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at human GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	134145071	156946	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3951664	156946	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL5275980	200660	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human GPR120 expressed in HEK293 cells assessed as calcium accumulationAgonist activity at human GPR120 expressed in HEK293 cells assessed as calcium accumulation	ChEMBL	462	7	1	3	6.9	OCCCc1c(F)cc(OCc2c(-c3ccc(Cl)cc3)csc2C(F)(F)F)cc1F	10.1021/acs.jmedchem.0c01002
	CHEMBL5278703	200769	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	438	6	2	7	4.3	Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
	134152545	160256	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3979588	160256	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	380	3	0	4	4.2	N#Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	134154975	158179	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	362	5	1	4	4.0	O=S(=O)(Nc1cc(F)cc(Oc2cccnc2)c1)c1ccc(F)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3961620	158179	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	362	5	1	4	4.0	O=S(=O)(Nc1cc(F)cc(Oc2cccnc2)c1)c1ccc(F)cc1	10.1021/acs.jmedchem.6b00685
	90418513	169402	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	429	8	1	4	6.2	CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4169436	169402	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	429	8	1	4	6.2	CCc1ccc(-c2snc(Cl)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	134155950	157869	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	430	6	1	4	4.6	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3959068	157869	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	430	6	1	4	4.6	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H]([C@@H]3C[C@H]3C(=O)O)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	134155847	157881	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	418	5	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3959144	157881	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	418	5	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134155480	158030	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3960231	158030	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	137654131	165793	0	None	-	0	Mouse	7.8	pEC50	=	7.8	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	416	5	1	4	5.3	COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
	CHEMBL4096579	165793	0	None	-	0	Mouse	7.8	pEC50	=	7.8	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	416	5	1	4	5.3	COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
	134143370	152581	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	442	7	1	6	4.0	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3916986	152581	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	442	7	1	6	4.0	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCc3nnn[nH]3)O4)c2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL5290651	201285	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	432	8	2	7	3.4	Cc1cc(OCc2nc(N)nc(NCCc3ccccc3C)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	127031003	145922	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	232	3	1	1	2.8	C/C=C\C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	CHEMBL3787072	145922	0	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	232	3	1	1	2.8	C/C=C\C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	8452407	187165	6	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	293	4	2	5	2.0	Nc1ccc(NS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-]	10.1016/j.bmcl.2020.127650
	CHEMBL4751828	187165	6	None	-	0	Human	4.8	pEC50	=	4.8	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	293	4	2	5	2.0	Nc1ccc(NS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-]	10.1016/j.bmcl.2020.127650
	78426052	184871	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	489	7	1	4	6.4	Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)c(F)c1	10.1016/j.bmc.2019.115263
	CHEMBL4647832	184871	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	489	7	1	4	6.4	Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CC(C)C(=O)O)cc2F)c(F)c1	10.1016/j.bmc.2019.115263
	CHEMBL5286962	201145	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	438	6	2	7	4.2	Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)ccc3C)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
	90418782	169862	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	513	7	1	4	6.6	O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4176642	169862	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	513	7	1	4	6.6	O=C(O)CCc1c(F)c(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	73777153	149601	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3893026	149601	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	355	3	1	2	5.2	O=C(O)CC1CCC2(CC1)CCN(c1cc(Cl)cc(Cl)c1)CC2	10.1021/acsmedchemlett.6b00360
	66562288	145787	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	246	3	1	1	3.2	C/C=C(/C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	CHEMBL3785637	145787	0	None	-	0	Human	4.7	pEC50	=	4.7	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	246	3	1	1	3.2	C/C=C(/C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	CHEMBL5285139	201059	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.4	Cc1cc(OCc2nc(N)nc(NCCc3cc(Cl)ccc3Cl)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	137633489	163379	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	368	5	1	5	4.0	N#Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1	10.1021/acs.jmedchem.7b00210
	CHEMBL4068825	163379	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	368	5	1	5	4.0	N#Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1	10.1021/acs.jmedchem.7b00210
	134148110	156349	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3946820	156349	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3nc(OC4CCC4)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	134134229	150033	0	None	-	0	Mouse	7.7	pEC50	=	7.7	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	CHEMBL3896657	150033	0	None	-	0	Mouse	7.7	pEC50	=	7.7	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	368	5	1	3	5.2	O=C(O)CCc1cc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2o1	10.1021/acsmedchemlett.6b00360
	90418753	169175	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	463	8	1	4	6.6	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4165803	169175	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	463	8	1	4	6.6	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2ccc(CCC(=O)O)c(C)c2C)cc1	10.1021/acsmedchemlett.7b00233
	73776997	161059	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	407	4	1	4	4.5	O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3986483	161059	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	407	4	1	4	4.5	O=C(O)CC1CCC2(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC2)OC1	10.1021/acsmedchemlett.6b00360
	16777240	186558	2	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	330	3	2	3	3.4	Cc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4744629	186558	2	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	330	3	2	3	3.4	Cc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL5278789	200774	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	508	7	2	8	4.8	Cc1ccc(Nc2nc(N)nc(COc3cc(OC(F)(F)F)cc(N4CCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
	156016724	184496	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human GPR120 expressed in CHO cells assessed as intracellular phosphorylated ERK incubated for 16 to 18 hrs by AlphaScreen SureFire assayAgonist activity at human GPR120 expressed in CHO cells assessed as intracellular phosphorylated ERK incubated for 16 to 18 hrs by AlphaScreen SureFire assay	ChEMBL	378	7	1	3	5.5	O=C(O)[C@H]1C[C@@H]1CCC12CCC(c3cccc(Oc4ccccc4)c3)(CC1)O2	10.1016/j.ejmech.2018.04.061
	CHEMBL4642294	184496	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at human GPR120 expressed in CHO cells assessed as intracellular phosphorylated ERK incubated for 16 to 18 hrs by AlphaScreen SureFire assayAgonist activity at human GPR120 expressed in CHO cells assessed as intracellular phosphorylated ERK incubated for 16 to 18 hrs by AlphaScreen SureFire assay	ChEMBL	378	7	1	3	5.5	O=C(O)[C@H]1C[C@@H]1CCC12CCC(c3cccc(Oc4ccccc4)c3)(CC1)O2	10.1016/j.ejmech.2018.04.061
	156016724	184496	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Modulation of GPR120 (unknown origin)Modulation of GPR120 (unknown origin)	ChEMBL	378	7	1	3	5.5	O=C(O)[C@H]1C[C@@H]1CCC12CCC(c3cccc(Oc4ccccc4)c3)(CC1)O2	10.1016/j.bmc.2019.115263
	CHEMBL4642294	184496	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Modulation of GPR120 (unknown origin)Modulation of GPR120 (unknown origin)	ChEMBL	378	7	1	3	5.5	O=C(O)[C@H]1C[C@@H]1CCC12CCC(c3cccc(Oc4ccccc4)c3)(CC1)O2	10.1016/j.bmc.2019.115263
	73777111	156489	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3947837	156489	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	134153546	159360	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3971857	159360	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	371	6	1	4	4.4	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)ncc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	137633536	163074	0	None	-	0	Rat	6.6	pEC50	=	6.6	Binding	Agonist activity at rat FFA4 receptorAgonist activity at rat FFA4 receptor	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4065397	163074	0	None	-	0	Rat	6.6	pEC50	=	6.6	Binding	Agonist activity at rat FFA4 receptorAgonist activity at rat FFA4 receptor	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	134145778	156126	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	355	3	0	3	4.3	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3945213	156126	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	355	3	0	3	4.3	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	134156727	160413	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3980898	160413	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	137650498	164101	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	382	5	1	5	4.3	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3C#N)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4077353	164101	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	382	5	1	5	4.3	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3C#N)ccc12	10.1021/acs.jmedchem.7b00210
	134134846	151017	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	337	3	0	3	4.2	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3904654	151017	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	337	3	0	3	4.2	O=S1(=O)c2ccccc2CN1c1cccc(Oc2ccccc2)c1	10.1021/acs.jmedchem.6b00685
	137641818	164986	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	373	6	1	5	4.1	COc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4087992	164986	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	373	6	1	5	4.1	COc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	73777085	160009	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3977361	160009	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL5285104	201058	0	None	-	0	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.4	Cc1cc(OCc2nc(N)nc(NCCc3ccc(Cl)cc3Cl)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	137651638	164000	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	371	6	1	4	4.8	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4076190	164000	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	371	6	1	4	4.8	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	137646368	164807	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	358	5	1	5	3.8	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ncc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4085695	164807	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	358	5	1	5	3.8	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ncc12	10.1021/acs.jmedchem.7b00210
	134154953	158055	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	369	3	0	3	4.6	Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3960369	158055	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	369	3	0	3	4.6	Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	66562289	145797	0	None	-	0	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	246	3	1	1	3.2	C/C=C(\C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	CHEMBL3785764	145797	0	None	-	0	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	246	3	1	1	3.2	C/C=C(\C)C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	134153067	159035	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	369	3	0	3	4.6	Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3969073	159035	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	369	3	0	3	4.6	Cc1ccccc1Oc1cc(F)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.6b00685
	78425909	184453	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	398	8	1	3	6.1	O=C(O)CCC12CCC(OCc3cc(F)cc(Oc4ccccc4)c3)(CC1)CC2	10.1016/j.bmc.2019.115263
	CHEMBL4641735	184453	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	398	8	1	3	6.1	O=C(O)CCC12CCC(OCc3cc(F)cc(Oc4ccccc4)c3)(CC1)CC2	10.1016/j.bmc.2019.115263
	117873187	159123	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	4	1	3	5.7	CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3969920	159123	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	4	1	3	5.7	CC1CC2(CCC1CC(=O)O)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	73777156	159494	0	None	-	0	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3973034	159494	0	None	-	0	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL5267225	200292	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	436	8	2	7	3.3	Cc1cc(OCc2nc(N)nc(NCCc3cccc(F)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	837245	17371	46	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	315	3	1	2	3.8	Cc1ccc(S(=O)(=O)Nc2cccc(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL1170012	17371	46	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	315	3	1	2	3.8	Cc1ccc(S(=O)(=O)Nc2cccc(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	73356514	97150	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	404	8	1	4	2.8	CS(=O)(=O)CCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	CHEMBL2386368	97150	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	404	8	1	4	2.8	CS(=O)(=O)CCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	73345870	97151	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	404	8	1	4	2.8	CS(=O)(=O)CCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	CHEMBL2386369	97151	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	404	8	1	4	2.8	CS(=O)(=O)CCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	73354950	97153	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	418	9	1	4	3.2	CS(=O)(=O)CCCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	CHEMBL2386370	97153	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	418	9	1	4	3.2	CS(=O)(=O)CCCOCc1ccccc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	73348895	97154	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	418	9	1	4	3.2	CS(=O)(=O)CCCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	CHEMBL2386371	97154	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	418	9	1	4	3.2	CS(=O)(=O)CCCOCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	CHEMBL5268800	200358	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	452	8	2	7	3.8	Cc1cc(OCc2nc(N)nc(NCCc3ccccc3Cl)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	73777111	156489	0	None	-	0	Mouse	5.5	pEC50	=	5.5	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3947837	156489	0	None	-	0	Mouse	5.5	pEC50	=	5.5	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	373	3	1	2	5.1	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL5289929	201264	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	458	6	2	7	4.5	Cc1ccc(Nc2nc(N)nc(COc3ccc(Cl)c(N4CCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
	156635006	186319	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	400	4	2	4	4.0	Nc1ccc(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	CHEMBL4741544	186319	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	400	4	2	4	4.0	Nc1ccc(NS(=O)(=O)c2ccc(OC(F)(F)F)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	117886639	155229	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	CHEMBL3937916	155229	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	CHEMBL5269158	200372	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	454	7	2	8	3.9	COc1ccc(OCc2nc(N)nc(Nc3ccc(C)c(Cl)c3)n2)cc1N1CCCC1=O	10.1021/acsmedchemlett.2c00160
	66562392	97147	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	336	3	1	1	4.6	O=C(O)CCc1ccc(C#Cc2cc(Cl)cc(Cl)c2)cc1F	10.1021/ml4000673
	CHEMBL2386365	97147	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	336	3	1	1	4.6	O=C(O)CCc1ccc(C#Cc2cc(Cl)cc(Cl)c2)cc1F	10.1021/ml4000673
	134138281	154564	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	410	7	1	6	3.9	COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3932664	154564	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	410	7	1	6	3.9	COc1cc(OC2CC2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	134138802	154697	0	None	-	0	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3933619	154697	0	None	-	0	Mouse	6.5	pEC50	=	6.5	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	383	4	1	3	4.7	O=C(O)C1CCN(c2ccc(-c3cc(OC(F)(F)F)ccc3F)cc2)CC1	10.1021/acsmedchemlett.6b00360
	134153986	159285	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3971308	159285	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	3	4.8	O=C(O)[C@@H]1C[C@H]1[C@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	117886649	158857	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	391	4	1	3	5.4	OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3967504	158857	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	391	4	1	3	5.4	OCCC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL5287009	201150	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	418	8	2	7	3.1	Cc1cc(OCc2nc(N)nc(NCCc3ccccc3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	118184919	169652	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	468	7	1	5	5.6	N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4173280	169652	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	468	7	1	5	5.6	N#Cc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	127030344	145923	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	242	3	1	1	3.2	O=C(O)CCc1ccc(C#CC2CCCC2)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3787110	145923	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	242	3	1	1	3.2	O=C(O)CCc1ccc(C#CC2CCCC2)cc1	10.1021/acs.jmedchem.5b01962
	127031002	145865	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	232	3	1	1	2.8	C/C=C/C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	CHEMBL3786526	145865	0	None	-	0	Human	4.5	pEC50	=	4.5	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	232	3	1	1	2.8	C/C=C/C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/acs.jmedchem.5b01962
	134132142	151647	0	None	-	0	Mouse	7.5	pEC50	=	7.5	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	CHEMBL3909872	151647	0	None	-	0	Mouse	7.5	pEC50	=	7.5	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	402	7	1	3	5.8	Cc1cc(-c2cc(OC(F)(F)F)ccc2Cl)cc(C)c1OCCCC(=O)O	10.1021/acsmedchemlett.6b00360
	1050	8683	94	None	-	2	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acs.jmedchem.0c01002
	11595431	8683	94	None	-	2	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acs.jmedchem.0c01002
	CHEMBL207881	8683	94	None	-	2	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	347	8	2	3	5.1	OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1	10.1021/acs.jmedchem.0c01002
	674995	149782	14	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	343	5	1	3	4.4	O=S(=O)(Nc1ccc(Oc2ccccc2)cc1)c1ccc(F)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3894632	149782	14	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	343	5	1	3	4.4	O=S(=O)(Nc1ccc(Oc2ccccc2)cc1)c1ccc(F)cc1	10.1021/acs.jmedchem.6b00685
	162672256	189651	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	346	4	2	4	3.1	COc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4791789	189651	0	None	-	0	Human	5.5	pEC50	=	5.5	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	346	4	2	4	3.1	COc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL5278642	200767	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	443	5	2	8	4.5	Cc1cc(=O)oc2cc(OCc3nc(N)nc(Nc4ccc(Cl)c(Cl)c4)n3)ccc12	10.1021/acsmedchemlett.2c00160
	137648938	164191	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	382	4	1	3	5.5	Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4078553	164191	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	382	4	1	3	5.5	Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	73777156	159494	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3973034	159494	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	396	4	1	4	4.7	N#Cc1ccc(OC(F)(F)F)cc1N1CCC2(CCC(CC(=O)O)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL5283269	200975	0	None	-	0	Human	4.4	pEC50	=	4.4	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	502	9	2	8	4.0	Cc1cc(OCc2nc(N)nc(NCCc3ccccc3OC(F)(F)F)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	71655293	97136	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	CHEMBL2386354	97136	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	71655227	97144	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	282	3	1	1	3.6	Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	CHEMBL2386362	97144	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	282	3	1	1	3.6	Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	134147107	156655	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	417	3	1	3	5.5	O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3949142	156655	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	417	3	1	3	5.5	O=C(O)C1CC12CCC1(CCN(c3cc(OC(F)(F)F)ccc3Cl)CC1)CC2	10.1021/acsmedchemlett.6b00360
	156635004	186491	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	344	4	2	3	3.7	CCc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4743951	186491	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	344	4	2	3	3.7	CCc1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	162674533	190244	0	None	-	0	Human	4.4	pEC50	=	4.4	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	372	3	2	3	4.4	CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4799103	190244	0	None	-	0	Human	4.4	pEC50	=	4.4	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	372	3	2	3	4.4	CC(C)(C)c1ccc(S(=O)(=O)Nc2ccc(N)c(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2020.127650
	134144000	156988	0	None	-	0	Mouse	8.3	pEC50	=	8.3	Binding	Agonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3952043	156988	0	None	-	0	Mouse	8.3	pEC50	=	8.3	Binding	Agonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	134132711	151716	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3910333	151716	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	372	3	0	4	4.2	O=S1(=O)c2ccccc2CN1c1cc(Cl)cc(Oc2ccccn2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL5273939	200566	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	466	8	2	7	4.1	Cc1cc(OCc2nc(N)nc(NCCc3ccc(Cl)c(C)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	137660172	165892	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	C[C@@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O	10.1021/acs.jmedchem.7b00210
	CHEMBL4097652	165892	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	C[C@@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O	10.1021/acs.jmedchem.7b00210
	117886639	155229	0	None	-	0	Mouse	5.4	pEC50	=	5.4	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	CHEMBL3937916	155229	0	None	-	0	Mouse	5.4	pEC50	=	5.4	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	391	3	1	3	5.3	CC1(C)Cc2cc(Cl)cc(N3CCC4(CCC(CC(=O)O)CC4)CC3)c2O1	10.1021/acsmedchemlett.6b00360
	127033352	145798	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	272	8	1	1	4.4	CCCCCCCC#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3785789	145798	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	272	8	1	1	4.4	CCCCCCCC#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.5b01962
	137658977	165883	0	None	-	0	Mouse	6.4	pEC50	=	6.4	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	385	5	1	5	4.3	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4097537	165883	0	None	-	0	Mouse	6.4	pEC50	=	6.4	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	385	5	1	5	4.3	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	137649363	164175	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	385	5	1	4	5.0	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CC(C)(C)C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4078374	164175	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	385	5	1	4	5.0	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CC(C)(C)C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	134146386	155686	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3941726	155686	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	384	5	1	3	5.0	O=C(O)CC[C@@H]1CCc2cc(-c3cc(OC(F)(F)F)ccc3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	73777174	157233	0	None	-	0	Mouse	5.4	pEC50	=	5.4	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3954140	157233	0	None	-	0	Mouse	5.4	pEC50	=	5.4	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	90442039	169688	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	509	7	1	4	7.1	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	CHEMBL4173940	169688	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	509	7	1	4	7.1	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)cc1C(F)(F)F	10.1021/acsmedchemlett.7b00233
	134132951	151400	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	454	8	1	7	3.9	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3907996	151400	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	454	8	1	7	3.9	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H](CCc2nnn[nH]2)O3)c1F	10.1021/acsmedchemlett.6b00394
	137652399	164274	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	C[C@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O	10.1021/acs.jmedchem.7b00210
	CHEMBL4079621	164274	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	C[C@H](Cc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1)C(=O)O	10.1021/acs.jmedchem.7b00210
	46892131	151449	2	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3908362	151449	2	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	O=S1(=O)c2ccccc2CN1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	134138099	154600	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	369	3	0	3	4.6	Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3932897	154600	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	369	3	0	3	4.6	Cc1ccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL5289774	201259	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	375	5	2	8	3.2	Cc1ccc(Nc2nc(N)nc(COc3ccc4ccc(=O)oc4c3)n2)cc1	10.1021/acsmedchemlett.2c00160
	73507535	184243	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	391	6	1	3	5.5	O=C(O)CCC1CCC2(CCN(c3cc(OC4CCC4)ccc3Cl)CC2)C1	10.1016/j.bmc.2019.115263
	CHEMBL4639009	184243	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	391	6	1	3	5.5	O=C(O)CCC1CCC2(CCN(c3cc(OC4CCC4)ccc3Cl)CC2)C1	10.1016/j.bmc.2019.115263
	73777065	154034	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	4	1	3	5.7	CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3928591	154034	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	4	1	3	5.7	CC(C(=O)O)C1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	137642248	164932	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1	10.1021/acs.jmedchem.7b00210
	CHEMBL4087308	164932	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	Cc1cc(-c2ccc(CCC(=O)O)cc2)cc2c1cnn2-c1ccccn1	10.1021/acs.jmedchem.7b00210
	137643731	165165	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	361	5	1	4	4.2	O=C(O)CCc1ccc(-c2cc(F)c3cnn(-c4ccccn4)c3c2)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4089919	165165	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	361	5	1	4	4.2	O=C(O)CCc1ccc(-c2cc(F)c3cnn(-c4ccccn4)c3c2)cc1	10.1021/acs.jmedchem.7b00210
	137658977	165883	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	385	5	1	5	4.3	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4097537	165883	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	385	5	1	5	4.3	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	73777069	149447	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3891920	149447	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	11195	10654	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assayAgonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	86280676	10654	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assayAgonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	CHEMBL3941880	10654	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assayAgonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assay	ChEMBL	356	3	0	4	3.7	Fc1cc(Oc2ccccn2)cc(c1)N1Cc2c(S1(=O)=O)cccc2	10.1021/acs.jmedchem.6b00685
	67072752	93304	0	None	-	1	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	CHEMBL2315528	93304	0	None	-	1	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/jm301470a
	127033353	145929	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	278	5	1	1	3.7	O=C(O)CCc1ccc(C#CCCc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3787151	145929	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	278	5	1	1	3.7	O=C(O)CCc1ccc(C#CCCc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
	73777135	157149	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3953289	157149	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	412	4	1	4	5.4	N#Cc1cc(SC(F)(F)F)cc(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	137632610	163125	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	368	5	1	5	4.0	N#Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4065890	163125	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	368	5	1	5	4.0	N#Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	743974	119804	70	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3311308	119804	70	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1021/acs.jmedchem.6b00685
	162673626	189972	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	350	3	2	3	3.7	Nc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	CHEMBL4795755	189972	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	350	3	2	3	3.7	Nc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	134144000	156988	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3952043	156988	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	431	8	1	6	4.0	COc1cc(O[C@H]2C[C@H](OC)C2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL5286838	201138	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human GPR120 expressed in CHO-K1 cells by beta-arrestin assayAgonist activity at human GPR120 expressed in CHO-K1 cells by beta-arrestin assay	ChEMBL	362	3	0	4	3.6	C#Cc1cc(Oc2cccnc2)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.0c01002
	134154415	159473	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	447	6	1	5	6.3	Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1	10.1021/acsmedchemlett.6b00394
	CHEMBL3972870	159473	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	447	6	1	5	6.3	Cc1cnc(Oc2cc(Cl)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)c2)s1	10.1021/acsmedchemlett.6b00394
	118679768	184399	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at FFA4 (unknown origin) expressed in CHO-K1 cells by BRET assayAgonist activity at FFA4 (unknown origin) expressed in CHO-K1 cells by BRET assay	ChEMBL	390	9	1	2	6.4	O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1	10.1016/j.ejmech.2018.04.061
	CHEMBL4641038	184399	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at FFA4 (unknown origin) expressed in CHO-K1 cells by BRET assayAgonist activity at FFA4 (unknown origin) expressed in CHO-K1 cells by BRET assay	ChEMBL	390	9	1	2	6.4	O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1	10.1016/j.ejmech.2018.04.061
	118679768	184399	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	390	9	1	2	6.4	O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1	10.1016/j.bmc.2019.115263
	CHEMBL4641038	184399	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	390	9	1	2	6.4	O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1	10.1016/j.bmc.2019.115263
	118679768	184399	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human GPR120 expressed in CHO-K1 cells by BRET assayAgonist activity at human GPR120 expressed in CHO-K1 cells by BRET assay	ChEMBL	390	9	1	2	6.4	O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1	10.1021/acs.jmedchem.0c01002
	CHEMBL4641038	184399	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human GPR120 expressed in CHO-K1 cells by BRET assayAgonist activity at human GPR120 expressed in CHO-K1 cells by BRET assay	ChEMBL	390	9	1	2	6.4	O=C(O)CCCc1ccc(OCC2=C(c3ccc(C4CC4)cc3)CCCC2)cc1	10.1021/acs.jmedchem.0c01002
	CHEMBL5272316	200495	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human GPR120 expressed in CHO-K1 cells by BRET assayAgonist activity at human GPR120 expressed in CHO-K1 cells by BRET assay	ChEMBL	364	8	1	2	5.8	Cc1ccc(C2=C(COc3ccc(CCCC(=O)O)cc3)CCCC2)cc1	10.1021/acs.jmedchem.0c01002
	CHEMBL5285896	201101	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human GPR120 expressed in CHO-K1 cells by BRET assayAgonist activity at human GPR120 expressed in CHO-K1 cells by BRET assay	ChEMBL	404	8	1	2	6.4	O=C(O)CCCc1ccc(OCC2=C(c3ccc4c(c3)CCCC4)CCCC2)cc1	10.1021/acs.jmedchem.0c01002
	CHEMBL5268182	200329	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	454	8	2	7	3.4	Cc1cc(OCc2nc(N)nc(NCCc3cc(F)ccc3F)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	46908122	158349	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	334	3	0	4	3.8	O=C1c2ccccc2C(=O)N1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3963275	158349	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	334	3	0	4	3.8	O=C1c2ccccc2C(=O)N1c1cc(F)cc(Oc2cccnc2)c1	10.1021/acs.jmedchem.6b00685
	162676836	190282	0	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	332	3	3	4	2.8	Nc1ccc(NS(=O)(=O)c2ccc(O)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	CHEMBL4799668	190282	0	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	332	3	3	4	2.8	Nc1ccc(NS(=O)(=O)c2ccc(O)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	90418476	169565	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	511	7	1	4	6.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4172136	169565	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	511	7	1	4	6.7	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(C(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	137645249	164390	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	403	5	1	5	4.4	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
	CHEMBL4080998	164390	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	403	5	1	5	4.4	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
	137648938	164191	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	382	4	1	3	5.5	Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4078553	164191	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	382	4	1	3	5.5	Cc1ccc(-n2nc(C)c3ccc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	156635003	187715	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	394	3	2	3	3.9	Nc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	CHEMBL4758125	187715	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	394	3	2	3	3.9	Nc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	137657813	166553	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	400	4	1	3	5.6	Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4105241	166553	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	400	4	1	3	5.6	Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	134147328	156828	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	394	4	0	4	4.4	N#CCc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3950610	156828	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	394	4	0	4	4.4	N#CCc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	162649435	186819	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	288	6	1	2	3.7	Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4747554	186819	0	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	288	6	1	2	3.7	Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
	73777085	160009	0	None	-	0	Mouse	5.3	pEC50	=	5.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL3977361	160009	0	None	-	0	Mouse	5.3	pEC50	=	5.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	351	4	1	3	4.6	COc1ccc(Cl)c(N2CCC3(CCC(CC(=O)O)CC3)CC2)c1	10.1021/acsmedchemlett.6b00360
	CHEMBL5283683	201004	0	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	482	9	2	8	3.8	COc1ccc(Cl)cc1CCNc1nc(N)nc(COc2cc(C)cc(N3CCCC3=O)c2)n1	10.1021/acsmedchemlett.2c00160
	2843133	154425	51	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	307	6	1	2	4.0	CCCCc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.6b00685
	CHEMBL3931570	154425	51	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	307	6	1	2	4.0	CCCCc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.6b00685
	73777063	7937	39	None	-	0	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	8418	7937	39	None	-	0	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	CHEMBL3919973	7937	39	None	-	0	Mouse	7.3	pEC50	=	7.3	Binding	Agonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in U2OS cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	137657813	166553	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	400	4	1	3	5.6	Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4105241	166553	0	None	-	0	Mouse	6.3	pEC50	=	6.3	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	400	4	1	3	5.6	Cc1ccc(-n2nc(C)c3c(F)cc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL5278391	200758	0	None	-	0	Human	4.3	pEC50	=	4.3	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.4	Cc1cc(OCc2nc(N)nc(NCCc3ccc(Cl)c(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	CHEMBL5273250	200533	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	437	6	2	8	4.4	CCc1ccc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
	134141650	153477	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	380	3	0	4	4.2	N#Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	CHEMBL3923955	153477	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assayAgonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	ChEMBL	380	3	0	4	4.2	N#Cc1cccc(Oc2cc(F)cc(N3Cc4ccccc4S3(=O)=O)c2)c1	10.1021/acs.jmedchem.6b00685
	66562390	97140	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	268	3	1	1	3.2	O=C(O)CCc1ccc(C#Cc2ccccc2)c(F)c1	10.1021/ml4000673
	CHEMBL2386358	97140	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	268	3	1	1	3.2	O=C(O)CCc1ccc(C#Cc2ccccc2)c(F)c1	10.1021/ml4000673
	162645828	186442	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	352	6	1	2	4.2	O=C(O)CCc1ccc(COc2cc(F)ccc2Br)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4743323	186442	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	352	6	1	2	4.2	O=C(O)CCc1ccc(COc2cc(F)ccc2Br)cc1	10.1016/j.bmcl.2020.127650
	73776995	155521	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	4	1	3	5.7	CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3940359	155521	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	419	4	1	3	5.7	CC1CC(CC(=O)O)CCC12CCN(c1cc(OC(F)(F)F)ccc1Cl)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL5278718	200771	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	424	6	2	7	3.9	Cc1ccc(Nc2nc(N)nc(COc3cccc(N4CCCC4=O)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
	90118275	184159	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	377	9	1	4	4.8	O=C(O)CCc1ccc(OCc2cccc(SCC3CC3)n2)c(Cl)c1	10.1016/j.bmc.2019.115263
	CHEMBL4637969	184159	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	377	9	1	4	4.8	O=C(O)CCc1ccc(OCc2cccc(SCC3CC3)n2)c(Cl)c1	10.1016/j.bmc.2019.115263
	156021563	184804	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	534	12	1	6	6.2	COc1ccc(F)c(-c2ncc(COc3ccc([C@@H](CC(=O)O)C4CC4)cc3)nc2OCCC(F)(F)F)c1	10.1016/j.bmc.2019.115263
	CHEMBL4646784	184804	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	534	12	1	6	6.2	COc1ccc(F)c(-c2ncc(COc3ccc([C@@H](CC(=O)O)C4CC4)cc3)nc2OCCC(F)(F)F)c1	10.1016/j.bmc.2019.115263
	134155067	158085	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	401	7	1	5	4.4	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3960738	158085	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	401	7	1	5	4.4	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	134156727	160413	0	None	-	0	Mouse	8.2	pEC50	=	8.2	Binding	Agonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL3980898	160413	0	None	-	0	Mouse	8.2	pEC50	=	8.2	Binding	Agonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at mouse GPR120 expressed in human U2OS cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	419	7	1	5	4.1	CO[C@H]1C[C@H](Oc2cc(F)c(F)c(-c3ccc4c(c3)CC[C@H](CCC(=O)O)O4)n2)C1	10.1021/acsmedchemlett.6b00394
	CHEMBL5286838	201138	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as cAMP accumulationAgonist activity at human GPR120 expressed in CHO-K1 cells assessed as cAMP accumulation	ChEMBL	362	3	0	4	3.6	C#Cc1cc(Oc2cccnc2)cc(N2Cc3ccccc3S2(=O)=O)c1	10.1021/acs.jmedchem.0c01002
	CHEMBL5268316	200338	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	438	6	2	7	4.2	Cc1cc(OCc2nc(N)nc(Nc3ccc(C)c(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	CHEMBL5268389	200342	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	423	5	2	8	4.2	Cc1cc(Nc2nc(N)nc(COc3ccc4c(C)cc(=O)oc4c3)n2)ccc1Cl	10.1021/acsmedchemlett.2c00160
	CHEMBL5287642	201167	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	454	7	2	8	3.9	COc1cc(OCc2nc(N)nc(Nc3ccc(C)c(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	137651358	163922	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	375	5	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3F)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4075162	163922	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	375	5	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3F)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL5278836	200778	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	452	8	2	7	3.8	Cc1cc(OCc2nc(N)nc(NCCc3cccc(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	162656082	187481	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	299	6	1	3	3.3	N#Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4755578	187481	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	299	6	1	3	3.3	N#Cc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
	90405673	184789	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	489	7	1	3	6.0	OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1	10.1016/j.bmc.2019.115263
	CHEMBL4646553	184789	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at GPR120 (unknown origin)Agonist activity at GPR120 (unknown origin)	ChEMBL	489	7	1	3	6.0	OCCCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Br)cc2)c(F)c1	10.1016/j.bmc.2019.115263
	90417978	168763	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4159180	168763	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	137645249	164390	0	None	-	0	Mouse	6.2	pEC50	=	6.2	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	403	5	1	5	4.4	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
	CHEMBL4080998	164390	0	None	-	0	Mouse	6.2	pEC50	=	6.2	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	403	5	1	5	4.4	COc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
	743974	119804	70	None	-	0	Mouse	5.2	pEC50	=	5.2	Binding	Agonist activity at mouse FFA4 receptor in mouse MIN6 cells assessed as induction of glucose-induced insulin secretion by AlphaLISAAgonist activity at mouse FFA4 receptor in mouse MIN6 cells assessed as induction of glucose-induced insulin secretion by AlphaLISA	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311308	119804	70	None	-	0	Mouse	5.2	pEC50	=	5.2	Binding	Agonist activity at mouse FFA4 receptor in mouse MIN6 cells assessed as induction of glucose-induced insulin secretion by AlphaLISAAgonist activity at mouse FFA4 receptor in mouse MIN6 cells assessed as induction of glucose-induced insulin secretion by AlphaLISA	ChEMBL	305	4	1	3	3.4	COc1ccc(S(=O)(=O)Nc2c(C)cc(C)cc2C)cc1	10.1016/j.bmcl.2014.05.012
	81762207	189526	1	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	266	3	2	3	2.2	Nc1ccc(NS(=O)(=O)c2ccccc2)cc1F	10.1016/j.bmcl.2020.127650
	CHEMBL4790052	189526	1	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	266	3	2	3	2.2	Nc1ccc(NS(=O)(=O)c2ccccc2)cc1F	10.1016/j.bmcl.2020.127650
	CHEMBL5266170	200249	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	480	6	2	7	5.2	Cc1ccc(Nc2nc(N)nc(COc3cc(N4CCCC4=O)cc(C(C)(C)C)c3)n2)cc1Cl	10.1021/acsmedchemlett.2c00160
	137649555	164109	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4077507	164109	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	357	5	1	4	4.4	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	137656733	166363	0	None	-	0	Mouse	6.2	pEC50	=	6.2	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	383	4	1	4	4.9	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4102951	166363	0	None	-	0	Mouse	6.2	pEC50	=	6.2	Binding	Agonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at mouse GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	383	4	1	4	4.9	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	66562388	97149	0	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	360	5	1	3	2.8	CS(=O)(=O)Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	CHEMBL2386367	97149	0	None	-	0	Human	4.2	pEC50	=	4.2	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	360	5	1	3	2.8	CS(=O)(=O)Cc1cccc(C#Cc2ccc(CCC(=O)O)c(F)c2)c1	10.1021/ml4000673
	73777063	7937	39	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	8418	7937	39	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	CHEMBL3919973	7937	39	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	405	4	1	3	5.5	OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(ccc1Cl)OC(F)(F)F	10.1021/acsmedchemlett.6b00360
	85470884	170783	2	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at recombinant human PK-tagged GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at recombinant human PK-tagged GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	CHEMBL4208325	170783	2	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at recombinant human PK-tagged GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at recombinant human PK-tagged GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	459	7	1	3	6.0	O=C(O)CCc1cc(F)c(OCc2c(C(F)(F)F)ccn2-c2ccc(Cl)cc2)c(F)c1	10.1016/j.bmcl.2018.02.013
	137637713	162635	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	369	4	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4060171	162635	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	369	4	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	134133355	150314	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	413	6	1	5	4.2	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3898962	150314	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	413	6	1	5	4.2	COc1cc(OC2CCC2)nc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	137633536	163074	0	None	-	0	Mouse	7.2	pEC50	=	7.2	Binding	Agonist activity at mouse FFA4 receptorAgonist activity at mouse FFA4 receptor	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4065397	163074	0	None	-	0	Mouse	7.2	pEC50	=	7.2	Binding	Agonist activity at mouse FFA4 receptorAgonist activity at mouse FFA4 receptor	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	73777069	149447	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3891920	149447	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	389	4	1	3	5.0	O=C(O)CC1CCC2(CC1)CCN(c1cc(OC(F)(F)F)ccc1F)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL5266730	200269	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.4	Cc1cc(OCc2nc(N)nc(NCCc3cc(Cl)cc(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	85472618	169089	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	491	7	1	4	6.7	Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4164509	169089	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	491	7	1	4	6.7	Cc1c(CCC(=O)O)cc(F)c(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c1F	10.1021/acsmedchemlett.7b00233
	156016929	184504	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Modulation of GPR120 (unknown origin)Modulation of GPR120 (unknown origin)	ChEMBL	540	7	1	7	5.3	COc1cc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)C4CC(=O)O)cc3)C(C)C2)c(Cl)cn1	10.1016/j.bmc.2019.115263
	CHEMBL4642324	184504	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Modulation of GPR120 (unknown origin)Modulation of GPR120 (unknown origin)	ChEMBL	540	7	1	7	5.3	COc1cc(N2CCC(Oc3ccc(N4N=C(C(F)(F)F)[C@@H](C)C4CC(=O)O)cc3)C(C)C2)c(Cl)cn1	10.1016/j.bmc.2019.115263
	137659366	166210	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	391	5	1	4	5.1	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3Cl)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4101071	166210	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	391	5	1	4	5.1	Cc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3Cl)ccc12	10.1021/acs.jmedchem.7b00210
	137638317	163501	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	387	6	1	5	4.4	COc1cc(CCC(=O)O)ccc1-c1ccc2c(C)nn(-c3ccccn3)c2c1	10.1021/acs.jmedchem.7b00210
	CHEMBL4070273	163501	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	387	6	1	5	4.4	COc1cc(CCC(=O)O)ccc1-c1ccc2c(C)nn(-c3ccccn3)c2c1	10.1021/acs.jmedchem.7b00210
	CHEMBL5267671	200314	0	None	-	0	Human	4.1	pEC50	=	4.1	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	446	8	2	7	3.7	Cc1cc(OCc2nc(N)nc(NCCc3c(C)cccc3C)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	137638318	163513	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	402	4	1	5	4.4	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4070359	163513	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	402	4	1	5	4.4	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4F)cc32)nc1	10.1021/acs.jmedchem.7b00210
	127031001	145911	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	242	3	1	1	3.4	CC(C)=C(C)C#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3786972	145911	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	242	3	1	1	3.4	CC(C)=C(C)C#Cc1ccc(CCC(=O)O)cc1	10.1021/acs.jmedchem.5b01962
	137651153	163983	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	371	6	1	4	4.7	CCc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4076004	163983	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	371	6	1	4	4.7	CCc1nn(-c2ccccn2)c2cc(-c3ccc(CCC(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	67072752	93304	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/ml4000673
	CHEMBL2315528	93304	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	289	4	1	2	3.2	N#CCc1ccccc1C#Cc1ccc(CCC(=O)O)cc1	10.1021/ml4000673
	137654131	165793	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	416	5	1	4	5.3	COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
	CHEMBL4096579	165793	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	416	5	1	4	5.3	COc1nn(-c2ccc(C)cc2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)cc(F)c12	10.1021/acs.jmedchem.7b00210
	134131620	149210	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	442	7	1	5	4.5	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3890035	149210	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	442	7	1	5	4.5	COc1cc(O[C@H]2C[C@H](OC)C2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	66562286	97141	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	268	3	1	1	3.2	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1F	10.1021/ml4000673
	CHEMBL2386359	97141	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	268	3	1	1	3.2	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1F	10.1021/ml4000673
	134153298	159145	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	412	6	1	4	4.8	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3970166	159145	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	412	6	1	4	4.8	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H]([C@@H]2C[C@H]2C(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	134131874	151635	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	404	6	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL3909773	151635	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	404	6	1	3	5.6	O=C(O)CC[C@H]1CCc2cc(-c3cc(OC4CCC4)cc(Cl)c3F)ccc2O1	10.1021/acsmedchemlett.6b00394
	CHEMBL5289306	201243	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	466	8	2	7	4.1	Cc1cc(OCc2nc(N)nc(NCCc3ccc(C)c(Cl)c3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	CHEMBL5267354	200302	0	None	-	0	Human	4.1	pEC50	=	4.1	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	503	9	2	9	3.0	Cc1cc(OCc2nc(N)nc(NCCc3ccccc3N3CCOCC3)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	85472227	168967	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	519	7	1	4	6.8	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4162566	168967	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	519	7	1	4	6.8	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(Br)c1	10.1021/acsmedchemlett.7b00233
	66562389	97142	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	286	3	1	1	3.4	O=C(O)CCc1c(F)cc(C#Cc2ccccc2)cc1F	10.1021/ml4000673
	CHEMBL2386360	97142	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	286	3	1	1	3.4	O=C(O)CCc1c(F)cc(C#Cc2ccccc2)cc1F	10.1021/ml4000673
	134156455	161100	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	394	6	1	5	4.3	Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	CHEMBL3986721	161100	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	394	6	1	5	4.3	Fc1ccc(OC2CCC2)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	137637713	162635	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	369	4	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	CHEMBL4060171	162635	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	369	4	1	4	4.6	Cc1nn(-c2ccccn2)c2cc(-c3ccc([C@H]4C[C@@H]4C(=O)O)cc3)ccc12	10.1021/acs.jmedchem.7b00210
	25149901	193465	1	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/ml4000673
	CHEMBL488384	193465	1	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/ml4000673
	25149901	193465	1	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL488384	193465	1	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	250	3	1	1	3.1	O=C(O)CCc1ccc(C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.5b01962
	85472225	169540	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4171724	169540	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	495	7	1	4	6.5	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(Cl)c(F)c3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	16775835	186942	2	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	316	3	2	3	3.1	Nc1ccc(NS(=O)(=O)c2ccccc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	CHEMBL4748982	186942	2	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	316	3	2	3	3.1	Nc1ccc(NS(=O)(=O)c2ccccc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	134152336	160235	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	408	5	1	5	4.2	Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	CHEMBL3979448	160235	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	408	5	1	5	4.2	Fc1ccc(OC(F)(F)F)cc1-c1ccc2c(c1)CC[C@H](CCc1nnn[nH]1)O2	10.1021/acsmedchemlett.6b00394
	16770747	188950	2	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	334	3	2	3	3.2	Nc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	CHEMBL4782622	188950	2	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	334	3	2	3	3.2	Nc1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1C(F)(F)F	10.1016/j.bmcl.2020.127650
	134145700	155530	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	400	7	1	4	5.0	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	CHEMBL3940429	155530	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayAgonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as beta-arrestin recruitment after 90 mins by luminescence assay	ChEMBL	400	7	1	4	5.0	COc1cc(OC2CCC2)cc(-c2ccc3c(c2)CC[C@H](CCC(=O)O)O3)c1F	10.1021/acsmedchemlett.6b00394
	137656733	166363	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	383	4	1	4	4.9	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4102951	166363	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	383	4	1	4	4.9	Cc1ccc(-n2nc(C)c3cnc(-c4ccc([C@H]5C[C@@H]5C(=O)O)cc4)cc32)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL5275546	200640	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	454	8	2	7	3.4	Cc1cc(OCc2nc(N)nc(NCCc3c(F)cccc3F)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	CHEMBL5282108	200924	0	None	-	0	Human	5.1	pEC50	=	5.1	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	486	8	2	7	4.4	Cc1cc(OCc2nc(N)nc(NCCc3cccc(Cl)c3Cl)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	90418333	169434	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	473	8	1	5	5.7	COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4169851	169434	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	473	8	1	5	5.7	COc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	71655226	97139	0	None	-	0	Human	4.0	pEC50	=	4.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	251	3	1	2	2.5	O=C(O)CCc1ccc(C#Cc2ccccc2)nc1	10.1021/ml4000673
	CHEMBL2386357	97139	0	None	-	0	Human	4.0	pEC50	=	4.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	251	3	1	2	2.5	O=C(O)CCc1ccc(C#Cc2ccccc2)nc1	10.1021/ml4000673
	73777174	157233	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL3954140	157233	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assayAgonist activity at ARMS2-PK2 -tagged human GPR120 short isoform expressed in CHOK1 cells assessed as induction of beta-arrestin2 recruitment after 90 mins by luminescence assay	ChEMBL	356	3	1	3	4.4	O=C(O)CC1CCC2(CC1)CCN(c1cc(C(F)(F)F)ccn1)CC2	10.1021/acsmedchemlett.6b00360
	CHEMBL5285725	201090	0	None	-	0	Human	4.0	pEC50	=	4.0	Binding	Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysisAgonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis	ChEMBL	446	8	2	7	3.7	Cc1cc(OCc2nc(N)nc(NCCc3ccc(C)cc3C)n2)cc(N2CCCC2=O)c1	10.1021/acsmedchemlett.2c00160
	6483	10658	54	None	-	1	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
	66553168	10658	54	None	-	1	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
	CHEMBL2386353	10658	54	None	-	1	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	4	1	2	3.3	N#CCc1ccccc1C#Cc1ccc(c(c1)F)CCC(=O)O	10.1021/ml4000673
	66562386	97145	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	3	1	2	3.4	Cc1ccc(C#N)cc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	CHEMBL2386363	97145	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assayAgonist activity at C-terminal yellow fluorescent protein-fused human FFA4 receptor transfected in HEK293 cells after 5 mins by BRET assay	ChEMBL	307	3	1	2	3.4	Cc1ccc(C#N)cc1C#Cc1ccc(CCC(=O)O)c(F)c1	10.1021/ml4000673
	127033020	145854	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	256	3	1	1	3.6	O=C(O)CCc1ccc(C#CC2CCCCC2)cc1	10.1021/acs.jmedchem.5b01962
	CHEMBL3786418	145854	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assayAgonist activity at human C-terminal YFP-tagged FFA4 receptor expressed in HEK293 cells incubated for 5 mins by BRET based beta-arrestin 2 recruitment assay	ChEMBL	256	3	1	1	3.6	O=C(O)CCc1ccc(C#CC2CCCCC2)cc1	10.1021/acs.jmedchem.5b01962
	162652317	187100	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	304	7	1	3	3.4	COc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4751137	187100	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	304	7	1	3	3.4	COc1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
	162672935	189981	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	332	7	1	4	3.2	COC(=O)c1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
	CHEMBL4795858	189981	0	None	-	0	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assayAgonist activity at human FFA4 receptor expressed in CHO-K1 cells assessed as increase in amplitude of dynamic mass redistribution response by DMR assay	ChEMBL	332	7	1	4	3.2	COC(=O)c1ccc(F)cc1OCc1ccc(CCC(=O)O)cc1	10.1016/j.bmcl.2020.127650
	85472359	168908	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	471	8	1	4	6.3	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	CHEMBL4161536	168908	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	471	8	1	4	6.3	CCc1ccc(-c2nsc(C(F)(F)F)c2COc2c(F)cc(CCC(=O)O)cc2F)cc1	10.1021/acsmedchemlett.7b00233
	85472487	169256	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	CHEMBL4167097	169256	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	477	7	1	4	6.4	O=C(O)CCc1ccc(OCc2c(-c3ccc(Cl)cc3)nsc2C(F)(F)F)c(F)c1F	10.1021/acsmedchemlett.7b00233
	145960576	168931	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	527	8	1	5	6.6	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	CHEMBL4161929	168931	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Agonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assayAgonist activity at PK-tagged human GPR120 long isoform expressed in CHOK1 cells co-expressing EA-tagged beta-arrestin assessed as beta-gal enzyme complex formation after 90 mins by enzyme fragment complementation assay	ChEMBL	527	8	1	5	6.6	O=C(O)CCc1cc(F)c(OCc2c(-c3ccc(OC(F)(F)F)cc3)nsc2C(F)(F)F)c(F)c1	10.1021/acsmedchemlett.7b00233
	137637243	162668	0	None	-	0	Human	6.0	pEC50	=	6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	343	5	1	4	4.1	O=C(O)CCc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1	10.1021/acs.jmedchem.7b00210
	CHEMBL4060517	162668	0	None	-	0	Human	6.0	pEC50	=	6	Binding	Agonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assayAgonist activity at human GPR120 expressed in CHO-FlpIn cells after 15 mins by DMR assay	ChEMBL	343	5	1	4	4.1	O=C(O)CCc1ccc(-c2ccc3cnn(-c4ccccn4)c3c2)cc1	10.1021/acs.jmedchem.7b00210
	134135468	151253	0	None	-	0	Mouse	6.0	pEC50	=	6	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	389	4	1	3	4.8	O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1	10.1021/acsmedchemlett.6b00360
	CHEMBL3906716	151253	0	None	-	0	Mouse	6.0	pEC50	=	6	Binding	Agonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitmentAgonist activity at mouse GPR120 assessed as induction of beta-arrestin recruitment	ChEMBL	389	4	1	3	4.8	O=C(O)C1CCC(C2CCN(c3cc(OC(F)(F)F)ccc3F)CC2)CC1	10.1021/acsmedchemlett.6b00360
	233085	119800	48	None	-	0	Mouse	8.1	pIC50	=	8.1	Binding	Inhibition of mouse FFA4 receptor expressed in U2OS cellsInhibition of mouse FFA4 receptor expressed in U2OS cells	ChEMBL	351	3	1	3	4.2	Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311302	119800	48	None	-	0	Mouse	8.1	pIC50	=	8.1	Binding	Inhibition of mouse FFA4 receptor expressed in U2OS cellsInhibition of mouse FFA4 receptor expressed in U2OS cells	ChEMBL	351	3	1	3	4.2	Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1	10.1016/j.bmcl.2014.05.012
	233085	119800	48	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Inhibition of rat FFA4 receptor expressed in U2OS cellsInhibition of rat FFA4 receptor expressed in U2OS cells	ChEMBL	351	3	1	3	4.2	Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311302	119800	48	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Inhibition of rat FFA4 receptor expressed in U2OS cellsInhibition of rat FFA4 receptor expressed in U2OS cells	ChEMBL	351	3	1	3	4.2	Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1	10.1016/j.bmcl.2014.05.012
	233085	119800	48	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of human FFA4 receptor expressed in U2OS cellsInhibition of human FFA4 receptor expressed in U2OS cells	ChEMBL	351	3	1	3	4.2	Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1	10.1016/j.bmcl.2014.05.012
	CHEMBL3311302	119800	48	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of human FFA4 receptor expressed in U2OS cellsInhibition of human FFA4 receptor expressed in U2OS cells	ChEMBL	351	3	1	3	4.2	Cc1ccc(S(=O)(=O)NC2c3ccccc3Oc3ccccc32)cc1	10.1016/j.bmcl.2014.05.012

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Main reference

Ligand source activities (1 row/activity)