GPCRdb

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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

	CHEMBL210692	78290	None	0	Human	Binding	IC50	=	2500.00	5.60	-	1	Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit	ChEMBL	316.1	3	2	6	2.82	COc1cc2c(c(O)c1OC)C(=O)C[C@@H](c1ccc(O)cc1)O2	https://dx.doi.org/10.1021/np200391c
	CHEMBL3315351	113372	None	15	Human	Binding	IC50	=	8000.00	5.10	-	1	Antagonist activity at human TAS2R31 expressed in HEK-293T cells stably expressing Galpha16gust44 assessed as inhibition receptor response to saccharin by fluorescence assay	ChEMBL	362.2	5	1	3	5.14	C=C1CC[C@H]2C(C)(C)[C@@H](OC(C)=O)CC[C@]2(C)[C@H]1CC/C(C)=C/C(=O)O	https://dx.doi.org/10.1021/np5001413
	CHEMBL490162	187048	None	1	Human	Binding	IC50	=	2000.00	5.70	-	1	Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit	ChEMBL	372.1	4	2	7	3.37	COc1cc([C@@H]2CC(=O)c3c(O)cc(O)cc3O2)ccc1OC(=O)C(C)C	https://dx.doi.org/10.1021/np200391c
	JACEOSIDINE	186513	None	55	Human	Binding	IC50	=	11300.00	4.95	-	1	Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit	ChEMBL	330.1	3	3	7	2.59	COc1cc(-c2cc(=O)c3c(O)c(OC)c(O)cc3o2)ccc1O	https://dx.doi.org/10.1021/np200391c
	sakuranetin	3460	None	34	Human	Binding	IC50	=	3600.00	5.44	-	4	Inhibition of human TAS2R31 receptor expressed in HEK293T cells overexpressing chimeric G-protein alpha-subunit	ChEMBL	286.1	2	2	5	2.81	COc1cc(O)c2c(c1)O[C@H](c1ccc(O)cc1)CC2=O	https://dx.doi.org/10.1021/np200391c

Showing 1 to 5 of 5 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

	acesulfame	253	None	0	Human	Functional	pEC50	=	-	2.60	1	2	Unclassified	Guide to Pharmacology	163.0	0	1	4	-0.72	CC1=CC(=O)NS(=O)(=O)O1	https://pubmed.ncbi.nlm.nih.gov/15537898
	aristolochic acid	471	None	0	Human	Functional	pEC50	=	-	6.35	-5	3	Unclassified	Guide to Pharmacology	341.1	3	1	6	3.34	COc1cccc2c1cc([N+](=O)[O-])c1c(C(=O)O)cc3c(c12)OCO3	https://pubmed.ncbi.nlm.nih.gov/15537898
	CHEMBL4440983	170016	None	0	Human	Functional	EC50	=	31500.00	4.50	-3	3	Agonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R44 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	250.2	0	1	3	2.60	C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)[C@@H]2CC1	-
	CHEMBL4582048	175800	None	0	Human	Functional	EC50	=	31500.00	4.50	-4	3	Agonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R44 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as effect on intracellular calcium level by FLIPR assay	ChEMBL	250.2	0	1	3	2.60	C/C1=C\C[C@H](O)/C(C)=C/[C@H]2OC(=O)[C@@H](C)C2CC1	-
	cyclamate	1276	None	0	Human	Functional	pIC50	=	-	1.79	-3	2	Unclassified	Guide to Pharmacology	179.1	2	2	2	0.71	O=S(=O)(O)NC1CCCCC1	https://pubmed.ncbi.nlm.nih.gov/28919036
	GIV3727	1802	None	0	Human	Functional	pIC50	=	-	5.46	1	3	Unclassified	Guide to Pharmacology	198.2	4	1	1	3.31	CC1CCC(CCCC(=O)O)C1(C)C	https://pubmed.ncbi.nlm.nih.gov/20537538
	isoprenaline	2091	None	34	Human	Functional	pEC50	=	8.31	8.08	-63	49	Agonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	Drug Central	211.1	4	4	4	1.13	CC(C)NCC(O)c1ccc(O)c(O)c1	-
	isoprenaline	2091	None	34	Human	Functional	EC50	=	4.90	8.31	-63	49	Agonist activity at human TAS2R44 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay	ChEMBL	211.1	4	4	4	1.13	CC(C)NCC(O)c1ccc(O)c(O)c1	-
	saccharin	3457	None	0	Human	Functional	pEC50	=	-	2.96	1	2	Unclassified	Guide to Pharmacology	183.0	0	1	3	0.12	O=C1NS(=O)(=O)c2ccccc21	https://pubmed.ncbi.nlm.nih.gov/15537898
	sakuranetin	3460	None	34	Human	Functional	pIC50	=	-	5.26	-	4	Unclassified	Guide to Pharmacology	286.1	2	2	5	2.81	COc1cc(O)c2c(c1)O[C@H](c1ccc(O)cc1)CC2=O	https://pubmed.ncbi.nlm.nih.gov/22059530

Showing 1 to 10 of 10 entries