GPCRdb

Ligand source activities (1 row/activity)

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	5803	390	15	None	-2	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1016/j.bmc.2018.09.015
	854189	390	15	None	-2	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1016/j.bmc.2018.09.015
	CHEMBL594671	390	15	None	-2	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1016/j.bmc.2018.09.015
	46235794	162385	0	None	2	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4174307	162385	0	None	2	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	67209751	161620	0	None	-3	2	Mouse	7.0	pEC50	=	7	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	505	10	1	6	6.0	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC3CCCC3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	CHEMBL4162307	161620	0	None	-3	2	Mouse	7.0	pEC50	=	7	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	505	10	1	6	6.0	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC3CCCC3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	117898644	162547	0	None	-3	2	Mouse	7.0	pEC50	=	7	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	515	10	1	7	5.7	CC(C)C[C@H](CC(=O)O)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4177037	162547	0	None	-3	2	Mouse	7.0	pEC50	=	7	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	515	10	1	7	5.7	CC(C)C[C@H](CC(=O)O)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	145953626	161961	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4167577	161961	0	None	-	1	Human	5.0	pEC50	=	5	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	145953603	161930	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	432	4	1	5	4.3	C#Cc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4167161	161930	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	432	4	1	5	4.3	C#Cc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1	10.1021/acs.jmedchem.8b00855
	145953670	162012	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	424	4	1	4	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4168456	162012	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	424	4	1	4	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	162666399	181803	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assayAgonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assay	ChEMBL	468	6	2	4	3.8	CC(Oc1cccc(Cl)c1)C(=O)N(C)[C@H]1CC[C@]2(CC1)NC(=N)N(Cc1ccccc1)C2=O	10.1016/j.bmcl.2020.127460
	CHEMBL4785193	181803	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assayAgonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assay	ChEMBL	468	6	2	4	3.8	CC(Oc1cccc(Cl)c1)C(=O)N(C)[C@H]1CC[C@]2(CC1)NC(=N)N(Cc1ccccc1)C2=O	10.1016/j.bmcl.2020.127460
	57520598	1782	27	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/acs.jmedchem.8b00855
	8417	1782	27	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/acs.jmedchem.8b00855
	CHEMBL3353541	1782	27	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/acs.jmedchem.8b00855
	DB15406	1782	27	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/acs.jmedchem.8b00855
	145951537	162159	0	None	3	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	537	10	1	7	6.0	COc1ccc(-c2ccc(Cl)cc2-c2csc(N(C(=O)[C@@H](CC(=O)O)Cc3ccco3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	CHEMBL4170829	162159	0	None	3	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	537	10	1	7	6.0	COc1ccc(-c2ccc(Cl)cc2-c2csc(N(C(=O)[C@@H](CC(=O)O)Cc3ccco3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	53302677	162297	0	None	1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4172928	162297	0	None	1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	67258265	162178	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	435	5	1	3	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4171128	162178	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	435	5	1	3	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145957026	161659	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4162808	161659	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00855
	117898634	161845	0	None	-5	2	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	479	10	1	6	5.5	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC(C)C)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	CHEMBL4165748	161845	0	None	-5	2	Mouse	6.9	pEC50	=	6.9	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	479	10	1	6	5.5	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC(C)C)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	145971768	162571	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	448	4	1	4	5.2	N#Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4177359	162571	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	448	4	1	4	5.2	N#Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	145971768	162571	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	448	4	1	4	5.2	N#Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4177359	162571	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	448	4	1	4	5.2	N#Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	145954653	162088	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	420	5	1	5	4.1	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccn2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4169673	162088	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	420	5	1	5	4.1	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccn2)cc1	10.1021/acs.jmedchem.8b00855
	53302677	162297	0	None	1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assayAgonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assay	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1016/j.bmcl.2020.127460
	CHEMBL4172928	162297	0	None	1	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assayAgonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assay	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1016/j.bmcl.2020.127460
	145951076	162423	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	408	4	1	5	4.3	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4175033	162423	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	408	4	1	5	4.3	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	145954653	162088	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	420	5	1	5	4.1	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccn2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4169673	162088	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	420	5	1	5	4.1	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccn2)cc1	10.1021/acs.jmedchem.8b00855
	145953670	162012	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	424	4	1	4	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4168456	162012	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	424	4	1	4	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	5803	390	15	None	2	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1016/j.bmc.2018.09.015
	854189	390	15	None	2	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1016/j.bmc.2018.09.015
	CHEMBL594671	390	15	None	2	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1016/j.bmc.2018.09.015
	67210172	161908	0	None	-5	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	440	8	1	4	5.3	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2ccccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4166818	161908	0	None	-5	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	440	8	1	4	5.3	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2ccccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	67209218	162330	0	None	-5	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	406	7	1	4	5.1	CN(C(=O)[C@@H](CC(=O)O)CC1CCCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4173387	162330	0	None	-5	2	Mouse	6.8	pEC50	=	6.8	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	406	7	1	4	5.1	CN(C(=O)[C@@H](CC(=O)O)CC1CCCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	67209297	162248	0	None	-7	2	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	422	7	1	5	4.3	CN(C(=O)[C@@H](CC(=O)O)CC1CCOCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4172349	162248	0	None	-7	2	Mouse	5.8	pEC50	=	5.8	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	422	7	1	5	4.3	CN(C(=O)[C@@H](CC(=O)O)CC1CCOCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	145952068	162313	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	477	4	1	4	5.1	COc1ccccc1C#Cc1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4173130	162313	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	477	4	1	4	5.1	COc1ccccc1C#Cc1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145950070	162216	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	438	5	1	6	4.3	COc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4171813	162216	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	438	5	1	6	4.3	COc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1	10.1021/acs.jmedchem.8b00855
	145949561	162390	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	409	5	1	5	4.3	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccco2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4174384	162390	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	409	5	1	5	4.3	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccco2)cc1	10.1021/acs.jmedchem.8b00855
	145954073	161943	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4167352	161943	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	67209297	162248	0	None	7	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	422	7	1	5	4.3	CN(C(=O)[C@@H](CC(=O)O)CC1CCOCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4172349	162248	0	None	7	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	422	7	1	5	4.3	CN(C(=O)[C@@H](CC(=O)O)CC1CCOCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	53302677	162297	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1021/acs.jmedchem.8b00855
	CHEMBL4172928	162297	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1021/acs.jmedchem.8b00855
	145955080	162080	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	465	5	1	4	5.6	CC(=O)c1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4169498	162080	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	465	5	1	4	5.6	CC(=O)c1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	145952174	162448	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	447	3	1	3	5.1	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4175443	162448	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	447	3	1	3	5.1	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	145954381	162025	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	530	6	1	5	6.9	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2c(-c3ccccc3)noc2C2CC2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4168646	162025	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	530	6	1	5	6.9	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2c(-c3ccccc3)noc2C2CC2)cc1	10.1021/acs.jmedchem.8b00855
	145962491	161821	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	427	4	1	5	4.1	Cn1nccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4165226	161821	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	427	4	1	5	4.1	Cn1nccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145949561	162390	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	409	5	1	5	4.3	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccco2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4174384	162390	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	409	5	1	5	4.3	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccco2)cc1	10.1021/acs.jmedchem.8b00855
	145956912	161503	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	453	5	1	4	5.4	COc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4160351	161503	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	453	5	1	4	5.4	COc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	145952068	162313	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	477	4	1	4	5.1	COc1ccccc1C#Cc1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4173130	162313	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	477	4	1	4	5.1	COc1ccccc1C#Cc1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145959365	161451	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	497	5	1	4	5.5	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Br)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4159447	161451	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	497	5	1	4	5.5	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Br)cc1	10.1021/acs.jmedchem.8b00855
	145951076	162423	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	408	4	1	5	4.3	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4175033	162423	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	408	4	1	5	4.3	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	145951986	162154	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4170748	162154	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	67209751	161620	0	None	3	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	505	10	1	6	6.0	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC3CCCC3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	CHEMBL4162307	161620	0	None	3	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	505	10	1	6	6.0	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC3CCCC3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	117898634	161845	0	None	5	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	479	10	1	6	5.5	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC(C)C)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	CHEMBL4165748	161845	0	None	5	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	479	10	1	6	5.5	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC(C)C)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	117898651	162343	0	None	3	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	541	10	1	7	6.2	O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4173663	162343	0	None	3	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	541	10	1	7	6.2	O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	117898644	162547	0	None	3	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	515	10	1	7	5.7	CC(C)C[C@H](CC(=O)O)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4177037	162547	0	None	3	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	515	10	1	7	5.7	CC(C)C[C@H](CC(=O)O)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	1032	3136	71	None	-13	2	Human	3.6	pEC50	=	3.6	Functional	Agonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method	ChEMBL	74	1	1	1	0.5	CCC(=O)O	10.1021/acs.jmedchem.7b00244
	1062	3136	71	None	-13	2	Human	3.6	pEC50	=	3.6	Functional	Agonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method	ChEMBL	74	1	1	1	0.5	CCC(=O)O	10.1021/acs.jmedchem.7b00244
	CHEMBL14021	3136	71	None	-13	2	Human	3.6	pEC50	=	3.6	Functional	Agonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method	ChEMBL	74	1	1	1	0.5	CCC(=O)O	10.1021/acs.jmedchem.7b00244
	DB03766	3136	71	None	-13	2	Human	3.6	pEC50	=	3.6	Functional	Agonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method	ChEMBL	74	1	1	1	0.5	CCC(=O)O	10.1021/acs.jmedchem.7b00244
	46235794	162385	0	None	-2	2	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4174307	162385	0	None	-2	2	Mouse	6.6	pEC50	=	6.6	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	145951986	162154	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4170748	162154	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145952606	162450	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.8b00855
	CHEMBL4175455	162450	0	None	-	1	Human	4.6	pEC50	=	4.6	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.8b00855
	145954073	161943	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4167352	161943	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	145957346	161421	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	419	5	1	4	4.7	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4159019	161421	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	419	5	1	4	4.7	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	67210172	161908	0	None	5	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	440	8	1	4	5.3	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2ccccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4166818	161908	0	None	5	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	440	8	1	4	5.3	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2ccccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	67209218	162330	0	None	5	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	406	7	1	4	5.1	CN(C(=O)[C@@H](CC(=O)O)CC1CCCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4173387	162330	0	None	5	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	406	7	1	4	5.1	CN(C(=O)[C@@H](CC(=O)O)CC1CCCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	145949794	162167	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4170872	162167	0	None	2	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at human FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	145953603	161930	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	432	4	1	5	4.3	C#Cc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4167161	161930	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	432	4	1	5	4.3	C#Cc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1	10.1021/acs.jmedchem.8b00855
	145959365	161451	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	497	5	1	4	5.5	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Br)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4159447	161451	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	497	5	1	4	5.5	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Br)cc1	10.1021/acs.jmedchem.8b00855
	145958427	161555	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	409	4	1	6	3.7	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccn2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4161202	161555	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	409	4	1	6	3.7	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccn2)cc1	10.1021/acs.jmedchem.8b00855
	138319694	162524	23	None	-5	2	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at mouse FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4176503	162524	23	None	-5	2	Mouse	6.4	pEC50	=	6.4	Functional	Agonist activity at mouse FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at mouse FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145951370	162231	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	437	4	1	3	5.7	Cc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4171999	162231	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	437	4	1	3	5.7	Cc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145952606	162450	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.8b00855
	CHEMBL4175455	162450	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.8b00855
	5803	390	15	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1021/acs.jmedchem.8b00855
	854189	390	15	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1021/acs.jmedchem.8b00855
	CHEMBL594671	390	15	None	-2	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1021/acs.jmedchem.8b00855
	145951370	162231	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	437	4	1	3	5.7	Cc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4171999	162231	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	437	4	1	3	5.7	Cc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145956912	161503	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	453	5	1	4	5.4	COc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4160351	161503	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	453	5	1	4	5.4	COc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	145959580	161787	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	443	4	1	4	5.7	Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)s1	10.1021/acs.jmedchem.8b00855
	CHEMBL4164813	161787	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	443	4	1	4	5.7	Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)s1	10.1021/acs.jmedchem.8b00855
	145949591	162171	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	471	5	1	4	5.5	COc1cccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)c1F	10.1021/acs.jmedchem.8b00855
	CHEMBL4170955	162171	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	471	5	1	4	5.5	COc1cccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)c1F	10.1021/acs.jmedchem.8b00855
	145951537	162159	0	None	-3	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	537	10	1	7	6.0	COc1ccc(-c2ccc(Cl)cc2-c2csc(N(C(=O)[C@@H](CC(=O)O)Cc3ccco3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	CHEMBL4170829	162159	0	None	-3	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	537	10	1	7	6.0	COc1ccc(-c2ccc(Cl)cc2-c2csc(N(C(=O)[C@@H](CC(=O)O)Cc3ccco3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	53302677	162297	0	None	-1	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4172928	162297	0	None	-1	2	Mouse	7.3	pEC50	=	7.3	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	138319694	162524	23	None	-5	2	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at FFA2R in mouse mature adipocytes assessed as inhibition of isoproterenol-induced glycerol productionAgonist activity at FFA2R in mouse mature adipocytes assessed as inhibition of isoproterenol-induced glycerol production	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4176503	162524	23	None	-5	2	Mouse	5.3	pEC50	=	5.3	Functional	Agonist activity at FFA2R in mouse mature adipocytes assessed as inhibition of isoproterenol-induced glycerol productionAgonist activity at FFA2R in mouse mature adipocytes assessed as inhibition of isoproterenol-induced glycerol production	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	67258265	162178	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	435	5	1	3	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4171128	162178	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	435	5	1	3	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145952174	162448	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	447	3	1	3	5.1	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4175443	162448	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	447	3	1	3	5.1	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	145957026	161659	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4162808	161659	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00855
	145958672	161567	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	457	4	1	3	6.0	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4161397	161567	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	457	4	1	3	6.0	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	138319694	162524	23	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4176503	162524	23	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	117898651	162343	0	None	-3	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	541	10	1	7	6.2	O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4173663	162343	0	None	-3	2	Mouse	7.1	pEC50	=	7.1	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	541	10	1	7	6.2	O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	145949794	162167	0	None	-2	2	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4170872	162167	0	None	-2	2	Mouse	6.1	pEC50	=	6.1	Functional	Agonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA methodAgonist activity at mouse FFA2R expressed in CHOK1 cells assessed as induction of GTPgamma35S binding preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	138319694	162524	23	None	5	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4176503	162524	23	None	5	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	162648013	179392	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assayAgonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assay	ChEMBL	427	8	1	4	6.3	Cc1nc(-c2ccccc2Cl)sc1COc1cccc([C@@H](CC(=O)O)C2CC2)c1	10.1016/j.bmcl.2020.127460
	CHEMBL4746807	179392	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assayAgonist activity at human FFAR2 expressed in HEK293 cells assessed as increase in cAMP level by HTRF assay	ChEMBL	427	8	1	4	6.3	Cc1nc(-c2ccccc2Cl)sc1COc1cccc([C@@H](CC(=O)O)C2CC2)c1	10.1016/j.bmcl.2020.127460
	145955080	162080	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	465	5	1	4	5.6	CC(=O)c1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4169498	162080	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	465	5	1	4	5.6	CC(=O)c1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)cc1	10.1021/acs.jmedchem.8b00855
	145953626	161961	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4167577	161961	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	145950070	162216	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	438	5	1	6	4.3	COc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4171813	162216	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	438	5	1	6	4.3	COc1ccccc1[C@H]1SC[C@@H](C(=O)O)N1C(=O)c1ccc(-c2c(C)noc2C)cc1	10.1021/acs.jmedchem.8b00855
	145958672	161567	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	457	4	1	3	6.0	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4161397	161567	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	457	4	1	3	6.0	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145949591	162171	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	471	5	1	4	5.5	COc1cccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)c1F	10.1021/acs.jmedchem.8b00855
	CHEMBL4170955	162171	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	471	5	1	4	5.5	COc1cccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)c1F	10.1021/acs.jmedchem.8b00855
	145959580	161787	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	443	4	1	4	5.7	Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)s1	10.1021/acs.jmedchem.8b00855
	CHEMBL4164813	161787	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	443	4	1	4	5.7	Cc1ccc(-c2ccc(C(=O)N3[C@H](C(=O)O)CS[C@@H]3c3ccccc3Cl)cc2)s1	10.1021/acs.jmedchem.8b00855
	145957346	161421	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	419	5	1	4	4.7	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4159019	161421	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assayAgonist activity at human FFA2R expressed in Flp-InT-REx 293 cells assessed as reduction of forskolin-induced cAMP production after 30 mins by TR-FRET assay	ChEMBL	419	5	1	4	4.7	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	145962491	161821	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	427	4	1	5	4.1	Cn1nccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4165226	161821	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assayAgonist activity to human FFA2R expressed in HEK293T cells assessed as induction beta-arrestin-2 recruitment after 10 mins by BRET assay	ChEMBL	427	4	1	5	4.1	Cn1nccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	46226274	200634	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	342	3	1	3	5.2	CC(C)(C)[C@H](C(=O)Nc1ncc(Cl)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL610333	200634	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	342	3	1	3	5.2	CC(C)(C)[C@H](C(=O)Nc1ncc(Cl)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	118719384	115025	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	384	5	1	2	3.8	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)NCc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3352999	115025	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	384	5	1	2	3.8	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)NCc2ccc(Cl)cc2)c1	10.1021/jm5012885
	68175794	115030	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	427	7	1	3	3.5	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCN)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353004	115030	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	427	7	1	3	3.5	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCN)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	118719385	115031	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	2	3	3.4	CNC(=O)NCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	CHEMBL3353005	115031	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	2	3	3.4	CNC(=O)NCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	46226177	198087	0	None	-	1	Human	4.0	pIC50	=	4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	279	4	2	4	2.2	CC(C)C(C(=O)Nc1nnn[nH]1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593826	198087	0	None	-	1	Human	4.0	pIC50	=	4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	279	4	2	4	2.2	CC(C)C(C(=O)Nc1nnn[nH]1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226178	198088	0	None	-	1	Human	4.0	pIC50	=	4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	277	4	2	2	3.4	CC(C)[C@H](C(=O)Nc1cc[nH]n1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593827	198088	0	None	-	1	Human	4.0	pIC50	=	4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	277	4	2	2	3.4	CC(C)[C@H](C(=O)Nc1cc[nH]n1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	847243	198236	11	None	-	1	Human	4.0	pIC50	=	4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	252	3	1	3	3.0	O=C(Cc1ccc(Cl)cc1)Nc1nccs1	10.1016/j.bmcl.2009.11.112
	CHEMBL594760	198236	11	None	-	1	Human	4.0	pIC50	=	4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	252	3	1	3	3.0	O=C(Cc1ccc(Cl)cc1)Nc1nccs1	10.1016/j.bmcl.2009.11.112
	46226356	198230	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	292	5	1	3	4.1	C=CC[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594738	198230	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	292	5	1	3	4.1	C=CC[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226144	198233	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	306	4	1	2	4.3	CC(C)[C@H](C(=O)Nc1cccc(F)n1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594746	198233	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	306	4	1	2	4.3	CC(C)[C@H](C(=O)Nc1cccc(F)n1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226383	200382	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	344	4	1	3	4.4	O=C(Nc1ncc(F)s1)[C@H](c1ccc(C(F)(F)F)cc1)C1CC1	10.1016/j.bmcl.2009.11.112
	CHEMBL608697	200382	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	344	4	1	3	4.4	O=C(Nc1ncc(F)s1)[C@H](c1ccc(C(F)(F)F)cc1)C1CC1	10.1016/j.bmcl.2009.11.112
	46226106	198438	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	225	3	1	1	2.8	CNC(=O)[C@H](c1ccc(Cl)cc1)C(C)C	10.1016/j.bmcl.2009.11.112
	CHEMBL596153	198438	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	225	3	1	1	2.8	CNC(=O)[C@H](c1ccc(Cl)cc1)C(C)C	10.1016/j.bmcl.2009.11.112
	77904272	115131	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	498	9	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)CCc2ccc(Cl)cc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353510	115131	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	498	9	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)CCc2ccc(Cl)cc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	70558275	115137	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	490	8	1	5	5.1	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353516	115137	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	490	8	1	5	5.1	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	89894240	115158	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	488	9	1	5	4.6	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	CHEMBL3353539	115158	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	488	9	1	5	4.6	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	70559113	115129	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353502	115129	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	46226336	198273	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	310	4	1	3	4.1	O=C(Nc1ncc(F)s1)[C@H](c1ccc(Cl)cc1)C1CC1	10.1016/j.bmcl.2009.11.112
	CHEMBL594998	198273	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	310	4	1	3	4.1	O=C(Nc1ncc(F)s1)[C@H](c1ccc(Cl)cc1)C1CC1	10.1016/j.bmcl.2009.11.112
	46226312	200060	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	474	4	2	4	5.9	CC(C)(C)[C@H](C(=O)Nc1ncc(C(O)(C(F)(F)F)C(F)(F)F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL606629	200060	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	474	4	2	4	5.9	CC(C)(C)[C@H](C(=O)Nc1ncc(C(O)(C(F)(F)F)C(F)(F)F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	29369661	198200	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	295	4	1	4	3.6	CC(C)[C@H](C(=O)Nc1nncs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594537	198200	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	295	4	1	4	3.6	CC(C)[C@H](C(=O)Nc1nncs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	68176091	115097	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	442	8	0	3	4.2	COCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	CHEMBL3353464	115097	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	442	8	0	3	4.2	COCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	70556816	115101	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	441	7	1	3	3.0	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(N)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353468	115101	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	441	7	1	3	3.0	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(N)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	70561343	115138	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	490	8	2	5	4.3	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353517	115138	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	490	8	2	5	4.3	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	46226145	200507	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	306	4	1	2	4.3	CC(C)[C@H](C(=O)Nc1ccc(F)cn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL609584	200507	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	306	4	1	2	4.3	CC(C)[C@H](C(=O)Nc1ccc(F)cn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70561241	115159	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	488	9	2	5	3.7	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	CHEMBL3353540	115159	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	488	9	2	5	3.7	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	46226143	198232	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	288	4	1	2	4.1	CC(C)[C@H](C(=O)Nc1ccccn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594745	198232	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	288	4	1	2	4.1	CC(C)[C@H](C(=O)Nc1ccccn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	9095896	198383	2	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	308	4	1	3	4.5	Cc1csc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)n1	10.1016/j.bmcl.2009.11.112
	CHEMBL595715	198383	2	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	308	4	1	3	4.5	Cc1csc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)n1	10.1016/j.bmcl.2009.11.112
	68175951	115126	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	412	4	0	3	4.8	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353498	115126	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	412	4	0	3	4.8	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	89900352	115099	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	479	8	0	4	5.4	CC1(C(=O)N(CCCC#N)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353466	115099	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	479	8	0	4	5.4	CC1(C(=O)N(CCCC#N)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	89900321	115026	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	398	5	0	2	4.1	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(C)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353000	115026	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	398	5	0	2	4.1	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(C)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	70556487	115024	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	412	5	1	3	4.4	CC1(C(=O)NCc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3352998	115024	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	412	5	1	3	4.4	CC1(C(=O)NCc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	46226360	200473	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	310	3	1	3	4.0	O=C(Nc1ncc(F)s1)C1(c2ccc(Cl)cc2)CCC1	10.1016/j.bmcl.2009.11.112
	CHEMBL609291	200473	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	310	3	1	3	4.0	O=C(Nc1ncc(F)s1)C1(c2ccc(Cl)cc2)CCC1	10.1016/j.bmcl.2009.11.112
	46226254	200545	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	362	4	1	3	5.2	CC(C)[C@H](C(=O)Nc1ncc(C(F)(F)F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL609861	200545	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	362	4	1	3	5.2	CC(C)[C@H](C(=O)Nc1ncc(C(F)(F)F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226290	200546	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	333	3	1	4	4.4	CC(C)(C)[C@H](C(=O)Nc1ncc(C#N)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL609863	200546	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	333	3	1	4	4.4	CC(C)(C)[C@H](C(=O)Nc1ncc(C#N)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226291	200809	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	376	3	1	3	5.6	CC(C)(C)[C@H](C(=O)Nc1ncc(C(F)(F)F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL611340	200809	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	376	3	1	3	5.6	CC(C)(C)[C@H](C(=O)Nc1ncc(C(F)(F)F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70565254	115148	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	476	9	2	4	3.6	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)c1	10.1021/jm5012885
	CHEMBL3353528	115148	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	476	9	2	4	3.6	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)c1	10.1021/jm5012885
	68176356	115104	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	469	9	1	3	3.8	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(N)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353471	115104	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	469	9	1	3	3.8	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(N)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	68176096	115103	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	469	7	0	3	3.6	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)N(C)C)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353470	115103	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	469	7	0	3	3.6	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)N(C)C)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	46226308	198229	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	351	4	1	4	4.6	CN(C)c1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)(C)C)s1	10.1016/j.bmcl.2009.11.112
	CHEMBL594737	198229	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	351	4	1	4	4.6	CN(C)c1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)(C)C)s1	10.1016/j.bmcl.2009.11.112
	46226309	199604	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	393	4	1	5	4.4	CC(C)(C)[C@H](C(=O)Nc1ncc(N2CCOCC2)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL604059	199604	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	393	4	1	5	4.4	CC(C)(C)[C@H](C(=O)Nc1ncc(N2CCOCC2)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226385	198313	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	311	4	1	4	3.5	O=C(Nc1ncc(F)s1)[C@H](c1ccnc(Cl)c1)C1CC1	10.1016/j.bmcl.2009.11.112
	CHEMBL595235	198313	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	311	4	1	4	3.5	O=C(Nc1ncc(F)s1)[C@H](c1ccnc(Cl)c1)C1CC1	10.1016/j.bmcl.2009.11.112
	89894379	132940	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	482	9	1	4	4.5	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	CHEMBL3706688	132940	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	482	9	1	4	4.5	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	46226235	200437	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	362	4	1	3	5.2	CC(C)[C@H](C(=O)Nc1nc(C(F)(F)F)cs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL608991	200437	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	362	4	1	3	5.2	CC(C)[C@H](C(=O)Nc1nc(C(F)(F)F)cs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70556496	115143	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	9	1	3	4.4	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353523	115143	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	9	1	3	4.4	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	46226251	200710	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	322	4	1	3	4.8	Cc1nc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)sc1C	10.1016/j.bmcl.2009.11.112
	CHEMBL610741	200710	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	322	4	1	3	4.8	Cc1nc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)sc1C	10.1016/j.bmcl.2009.11.112
	36477073	198242	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	363	4	1	4	4.6	CC(C)[C@H](C(=O)Nc1nnc(C(F)(F)F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594770	198242	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	363	4	1	4	4.6	CC(C)[C@H](C(=O)Nc1nnc(C(F)(F)F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226255	198093	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	319	4	1	4	4.0	CC(C)[C@H](C(=O)Nc1ncc(C#N)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593839	198093	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	319	4	1	4	4.0	CC(C)[C@H](C(=O)Nc1ncc(C#N)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	39725404	198186	1	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	352	5	1	5	4.0	COC(=O)c1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)s1	10.1016/j.bmcl.2009.11.112
	CHEMBL594505	198186	1	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	352	5	1	5	4.0	COC(=O)c1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)s1	10.1016/j.bmcl.2009.11.112
	46226163	198243	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	295	4	1	4	3.6	CC(C)[C@H](C(=O)Nc1ncns1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594771	198243	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	295	4	1	4	3.6	CC(C)[C@H](C(=O)Nc1ncns1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	135971436	198000	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	310	3	1	3	2.8	CC(C)[C@H](C(=O)NC1=NC(=O)CS1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593121	198000	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	310	3	1	3	2.8	CC(C)[C@H](C(=O)NC1=NC(=O)CS1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226164	198068	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	277	4	2	2	3.4	CC(C)[C@H](C(=O)Nc1ncc[nH]1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593607	198068	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	277	4	2	2	3.4	CC(C)[C@H](C(=O)Nc1ncc[nH]1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	2520490	197999	2	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	296	3	1	3	3.3	CC(C)[C@H](C(=O)NC1=NCCS1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593120	197999	2	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	296	3	1	3	3.3	CC(C)[C@H](C(=O)NC1=NCCS1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	89894269	132941	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	454	7	1	4	3.7	CC1(C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	CHEMBL3706689	132941	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	454	7	1	4	3.7	CC1(C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	46226161	198039	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	289	4	1	3	3.5	CC(C)[C@H](C(=O)Nc1cccnn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593435	198039	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	289	4	1	3	3.5	CC(C)[C@H](C(=O)Nc1cccnn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226311	198188	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	441	4	1	6	3.8	CC(C)(C)[C@H](C(=O)Nc1ncc(N2CCS(=O)(=O)CC2)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594507	198188	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	441	4	1	6	3.8	CC(C)(C)[C@H](C(=O)Nc1ncc(N2CCS(=O)(=O)CC2)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	68176357	115111	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	505	9	1	4	3.2	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCS(N)(=O)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353478	115111	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	505	9	1	4	3.2	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCS(N)(=O)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	89900347	115098	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	451	6	0	4	4.6	CC1(C(=O)N(CC#N)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353465	115098	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	451	6	0	4	4.6	CC1(C(=O)N(CC#N)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	70559604	115135	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)Cc2cccc(Cl)c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353514	115135	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)Cc2cccc(Cl)c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	46226162	198040	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	278	4	1	3	3.7	CC(C)[C@H](C(=O)Nc1ncco1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593436	198040	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	278	4	1	3	3.7	CC(C)[C@H](C(=O)Nc1ncco1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226295	198125	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	432	5	1	3	6.8	CC(C)(C)[C@H](C(=O)Nc1ncc(Cc2ccc(Cl)cc2)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594074	198125	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	432	5	1	3	6.8	CC(C)(C)[C@H](C(=O)Nc1ncc(Cc2ccc(Cl)cc2)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70559551	115134	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	518	8	1	4	5.4	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353513	115134	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	518	8	1	4	5.4	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	89894353	115156	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	516	9	1	4	4.9	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	CHEMBL3353536	115156	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	516	9	1	4	4.9	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	89900371	115115	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	519	10	1	4	3.5	CNS(=O)(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	CHEMBL3353481	115115	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	519	10	1	4	3.5	CNS(=O)(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	89900327	115027	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	426	5	0	3	4.7	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353001	115027	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	426	5	0	3	4.7	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	70558376	115116	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	442	7	1	3	3.6	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353482	115116	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	442	7	1	3	3.6	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	88757504	115142	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	471	7	1	5	4.5	CC1(C(=O)N(CCCC(=O)O)c2ccc(Cl)nc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353522	115142	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	471	7	1	5	4.5	CC1(C(=O)N(CCCC(=O)O)c2ccc(Cl)nc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	46226182	200544	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	344	4	1	3	5.3	CC(C)C(C(=O)Nc1nc2ccccc2s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL609852	200544	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	344	4	1	3	5.3	CC(C)C(C(=O)Nc1nc2ccccc2s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70558485	115118	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	4.6	CC1(C(=O)N(CCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353484	115118	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	4.6	CC1(C(=O)N(CCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	70557254	115139	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	507	8	1	6	5.0	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3scnc3c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353518	115139	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	507	8	1	6	5.0	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3scnc3c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	118719612	115013	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	426	5	0	4	4.3	COc1c(C(=O)N2CCC2(C)C(=O)N(C)Cc2ccc(Cl)cc2)csc1Cl	10.1021/jm5012885
	CHEMBL3352828	115013	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	426	5	0	4	4.3	COc1c(C(=O)N2CCC2(C)C(=O)N(C)Cc2ccc(Cl)cc2)csc1Cl	10.1021/jm5012885
	68176101	115029	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	456	7	1	4	4.1	CC1(C(=O)N(CCO)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353003	115029	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	456	7	1	4	4.1	CC1(C(=O)N(CCO)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	118719611	115123	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	406	4	0	2	4.8	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1cccc2ccccc12	10.1021/jm5012885
	CHEMBL3353491	115123	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	406	4	0	2	4.8	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1cccc2ccccc12	10.1021/jm5012885
	118719617	115127	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	446	4	0	3	5.5	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1csc2ccc(Cl)cc12	10.1021/jm5012885
	CHEMBL3353499	115127	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	446	4	0	3	5.5	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1csc2ccc(Cl)cc12	10.1021/jm5012885
	70557757	115145	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	9	1	3	4.4	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2cccc(Cl)c2)c1	10.1021/jm5012885
	CHEMBL3353525	115145	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	9	1	3	4.4	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2cccc(Cl)c2)c1	10.1021/jm5012885
	118719609	115109	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	497	8	1	4	4.3	CC(=O)NCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353476	115109	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	497	8	1	4	4.3	CC(=O)NCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	46226293	200508	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	386	4	1	5	4.0	CC(C)(C)[C@H](C(=O)Nc1ncc(S(C)(=O)=O)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL609586	200508	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	386	4	1	5	4.0	CC(C)(C)[C@H](C(=O)Nc1ncc(S(C)(=O)=O)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70556905	115133	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	7	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)c2cccc(Cl)c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353512	115133	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	7	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)c2cccc(Cl)c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	70556713	115117	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	7	1	4	4.2	CC1(C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353483	115117	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	7	1	4	4.2	CC1(C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	70559086	115153	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	504	9	1	5	5.1	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353533	115153	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	504	9	1	5	5.1	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	46226179	200346	0	None	-	1	Human	4.4	pIC50	=	4.4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	278	4	1	3	3.7	CC(C)[C@H](C(=O)Nc1ccon1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL608384	200346	0	None	-	1	Human	4.4	pIC50	=	4.4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	278	4	1	3	3.7	CC(C)[C@H](C(=O)Nc1ccon1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70559096	115100	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	9	0	4	4.5	COC(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	CHEMBL3353467	115100	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	9	0	4	4.5	COC(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	46226310	198187	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	406	4	1	5	4.3	CN1CCN(c2cnc(NC(=O)[C@H](c3ccc(Cl)cc3)C(C)(C)C)s2)CC1	10.1016/j.bmcl.2009.11.112
	CHEMBL594506	198187	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	406	4	1	5	4.3	CN1CCN(c2cnc(NC(=O)[C@H](c3ccc(Cl)cc3)C(C)(C)C)s2)CC1	10.1016/j.bmcl.2009.11.112
	89900361	115107	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	539	9	0	4	4.2	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353474	115107	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	539	9	0	4	4.2	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	70562777	115154	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	504	9	2	5	4.2	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353534	115154	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	504	9	2	5	4.2	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cn[nH]c3c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	70557843	115119	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	498	9	1	4	5.0	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353485	115119	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	498	9	1	4	5.0	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	68175817	115110	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	505	9	1	4	3.1	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCNS(C)(=O)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353477	115110	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	505	9	1	4	3.1	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCNS(C)(=O)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	46226234	200709	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	362	4	1	3	5.5	CC(C)[C@H](C(=O)Nc1nc2cc(Cl)ccc2o1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL610740	200709	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	362	4	1	3	5.5	CC(C)[C@H](C(=O)Nc1nc2cc(Cl)ccc2o1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	89901463	115114	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	547	10	1	5	4.1	CNS(=O)(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353480	115114	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	547	10	1	5	4.1	CNS(=O)(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	68176095	115102	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	455	7	1	3	3.3	CNC(=O)CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	CHEMBL3353469	115102	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	455	7	1	3	3.3	CNC(=O)CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	89900348	115124	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	423	5	0	3	4.0	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cn(C)c2ccccc12	10.1021/jm5012885
	CHEMBL3353492	115124	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	423	5	0	3	4.0	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cn(C)c2ccccc12	10.1021/jm5012885
	46226386	198194	0	None	-	1	Human	4.4	pIC50	=	4.4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	277	4	1	4	2.8	O=C(Nc1ncc(F)s1)[C@H](c1ccccn1)C1CC1	10.1016/j.bmcl.2009.11.112
	CHEMBL594528	198194	0	None	-	1	Human	4.4	pIC50	=	4.4	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	277	4	1	4	2.8	O=C(Nc1ncc(F)s1)[C@H](c1ccccn1)C1CC1	10.1016/j.bmcl.2009.11.112
	46226333	198237	0	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	266	3	1	3	3.5	C[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594761	198237	0	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	266	3	1	3	3.5	C[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	89900346	115106	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	511	7	0	4	3.4	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353473	115106	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	511	7	0	4	3.4	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	68176013	115028	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	412	6	0	2	4.5	CCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	CHEMBL3353002	115028	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	412	6	0	2	4.5	CCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1	10.1021/jm5012885
	70564780	115152	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	503	9	2	4	4.8	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353532	115152	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	503	9	2	4	4.8	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	46226142	198231	0	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	288	4	1	2	4.1	CC(C)C(C(=O)Nc1cccnc1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594744	198231	0	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	288	4	1	2	4.1	CC(C)C(C(=O)Nc1cccnc1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	3420	3392	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	312	4	1	3	4.3	CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2009.11.112
	46226252	3392	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	312	4	1	3	4.3	CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2009.11.112
	CHEMBL594525	3392	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	312	4	1	3	4.3	CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2009.11.112
	46226292	198235	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	354	4	1	4	5.3	CSc1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)(C)C)s1	10.1016/j.bmcl.2009.11.112
	CHEMBL594758	198235	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	354	4	1	4	5.3	CSc1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)(C)C)s1	10.1016/j.bmcl.2009.11.112
	70557810	115151	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	498	9	1	4	5.0	CC1(C(=O)N(CCCC(=O)O)Cc2cccc(Cl)c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353531	115151	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	498	9	1	4	5.0	CC1(C(=O)N(CCCC(=O)O)Cc2cccc(Cl)c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	46226361	198267	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	324	3	1	3	4.4	O=C(Nc1ncc(F)s1)C1(c2ccc(Cl)cc2)CCCC1	10.1016/j.bmcl.2009.11.112
	CHEMBL594974	198267	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	324	3	1	3	4.4	O=C(Nc1ncc(F)s1)C1(c2ccc(Cl)cc2)CCCC1	10.1016/j.bmcl.2009.11.112
	46226334	200547	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	280	4	1	3	3.9	CC[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL609870	200547	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	280	4	1	3	3.9	CC[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226358	200901	0	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	298	3	1	3	3.9	CC(C)(C(=O)Nc1ncc(F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL611948	200901	0	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	298	3	1	3	3.9	CC(C)(C(=O)Nc1ncc(F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	89900356	115128	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	426	5	0	3	4.7	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc2ccccc2s1	10.1021/jm5012885
	CHEMBL3353500	115128	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	426	5	0	3	4.7	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc2ccccc2s1	10.1021/jm5012885
	70556743	115130	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	455	7	1	5	3.1	CC1(C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1noc2ccccc12	10.1021/jm5012885
	CHEMBL3353505	115130	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	455	7	1	5	3.1	CC1(C(=O)N(CC(=O)O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1noc2ccccc12	10.1021/jm5012885
	70558482	115125	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	396	4	0	3	4.3	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1ccc2occc2c1	10.1021/jm5012885
	CHEMBL3353495	115125	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	396	4	0	3	4.3	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1ccc2occc2c1	10.1021/jm5012885
	68176100	115105	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	455	8	1	3	3.4	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCC(N)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	CHEMBL3353472	115105	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	455	8	1	3	3.4	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCC(N)=O)Cc2ccc(Cl)cc2)c1	10.1021/jm5012885
	4964042	200588	5	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	327	4	2	2	4.6	CC(C)C(C(=O)Nc1nc2ccccc2[nH]1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL610060	200588	5	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	327	4	2	2	4.6	CC(C)C(C(=O)Nc1nc2ccccc2[nH]1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226146	198030	0	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	289	4	1	3	3.5	CC(C)C(C(=O)Nc1ncccn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593351	198030	0	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	289	4	1	3	3.5	CC(C)C(C(=O)Nc1ncccn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226335	198238	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	294	5	1	3	4.3	CCC[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594762	198238	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	294	5	1	3	4.3	CCC[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70559021	115144	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	504	9	1	3	4.7	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)c1	10.1021/jm5012885
	CHEMBL3353524	115144	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	504	9	1	3	4.7	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)c1	10.1021/jm5012885
	25479840	198037	1	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	288	4	1	2	4.1	CC(C)[C@H](C(=O)Nc1ccncc1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593433	198037	1	None	-	1	Human	4.3	pIC50	=	4.3	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	288	4	1	2	4.1	CC(C)[C@H](C(=O)Nc1ccncc1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70557930	115150	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	532	9	1	4	5.3	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353530	115150	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	532	9	1	4	5.3	CC1(C(=O)N(CCCC(=O)O)Cc2ccc(C(F)(F)F)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	46226160	200856	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	289	4	1	3	3.5	CC(C)C(C(=O)Nc1cnccn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL611632	200856	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	289	4	1	3	3.5	CC(C)C(C(=O)Nc1cnccn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226180	198498	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	295	4	1	4	3.6	CC(C)[C@H](C(=O)Nc1cnns1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL596580	198498	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	295	4	1	4	3.6	CC(C)[C@H](C(=O)Nc1cnns1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70559585	115140	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	471	7	1	5	4.5	CC1(C(=O)N(CCCC(=O)O)c2cc(Cl)ccn2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353520	115140	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	471	7	1	5	4.5	CC1(C(=O)N(CCCC(=O)O)c2cc(Cl)ccn2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	118719610	115122	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	452	6	0	3	5.3	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc(-c2ccsc2)c1	10.1021/jm5012885
	CHEMBL3353490	115122	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	452	6	0	3	5.3	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc(-c2ccsc2)c1	10.1021/jm5012885
	46226337	200381	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	308	5	1	3	4.6	CC(C)C[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL608696	200381	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	308	5	1	3	4.6	CC(C)C[C@H](C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70557795	115132	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	7	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)c2ccc(Cl)cc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353511	115132	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	470	7	1	4	5.1	CC1(C(=O)N(CCCC(=O)O)c2ccc(Cl)cc2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	70564643	115136	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	489	8	2	4	4.9	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353515	115136	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	489	8	2	4	4.9	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	70559574	115141	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	471	7	1	5	4.5	CC1(C(=O)N(CCCC(=O)O)c2ccc(Cl)cn2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353521	115141	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	471	7	1	5	4.5	CC1(C(=O)N(CCCC(=O)O)c2ccc(Cl)cn2)CCN1C(=O)c1csc2ccccc12	10.1021/jm5012885
	5803	390	15	None	-2	2	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2009.11.112
	854189	390	15	None	-2	2	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2009.11.112
	CHEMBL594671	390	15	None	-2	2	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	10.1016/j.bmcl.2009.11.112
	12861	1176	20	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	384	4	1	3	6.2	CC(C)(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=NC=C(S2)C3=CC=CC=C3	10.1016/j.bmcl.2009.11.112
	46226294	1176	20	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	384	4	1	3	6.2	CC(C)(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=NC=C(S2)C3=CC=CC=C3	10.1016/j.bmcl.2009.11.112
	CHEMBL607315	1176	20	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	384	4	1	3	6.2	CC(C)(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=NC=C(S2)C3=CC=CC=C3	10.1016/j.bmcl.2009.11.112
	46226275	198027	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	386	3	1	3	5.3	CC(C)(C)[C@H](C(=O)Nc1ncc(Br)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593344	198027	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	386	3	1	3	5.3	CC(C)(C)[C@H](C(=O)Nc1ncc(Br)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226273	200807	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	326	3	1	3	4.7	CC(C)(C)[C@H](C(=O)Nc1ncc(F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL611338	200807	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	326	3	1	3	4.7	CC(C)(C)[C@H](C(=O)Nc1ncc(F)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226253	200808	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	328	4	1	3	4.8	CC(C)[C@H](C(=O)Nc1ncc(Cl)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL611339	200808	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	328	4	1	3	4.8	CC(C)[C@H](C(=O)Nc1ncc(Cl)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226272	200251	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	337	5	2	4	3.3	CC(C)[C@H](C(=O)Nc1ncc(C(N)=O)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL607691	200251	0	None	-	1	Human	4.2	pIC50	=	4.2	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	337	5	2	4	3.3	CC(C)[C@H](C(=O)Nc1ncc(C(N)=O)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70559626	115149	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	493	9	1	5	4.3	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3scnc3c2)c1	10.1021/jm5012885
	CHEMBL3353529	115149	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	493	9	1	5	4.3	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3scnc3c2)c1	10.1021/jm5012885
	89900365	115108	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	567	9	0	5	4.8	CC1(C(=O)N(CCCC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353475	115108	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	567	9	0	5	4.8	CC1(C(=O)N(CCCC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	89900378	115112	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	533	9	1	5	3.8	CC1(C(=O)N(CCCS(N)(=O)=O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353479	115112	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	533	9	1	5	3.8	CC1(C(=O)N(CCCS(N)(=O)=O)Cc2ccc(Cl)cc2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	68175329	115121	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	446	6	0	2	5.2	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc(-c2ccccc2)c1	10.1021/jm5012885
	CHEMBL3353489	115121	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	446	6	0	2	5.2	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc(-c2ccccc2)c1	10.1021/jm5012885
	70558983	115147	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	476	9	1	4	4.5	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)c1	10.1021/jm5012885
	CHEMBL3353527	115147	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	476	9	1	4	4.5	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3ccoc3c2)c1	10.1021/jm5012885
	68175946	115120	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	406	5	0	2	3.8	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(F)cc(F)c1	10.1021/jm5012885
	CHEMBL3353487	115120	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	406	5	0	2	3.8	CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(F)cc(F)c1	10.1021/jm5012885
	46226236	198120	1	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	350	4	1	3	5.5	CC(C)[C@H](C(=O)Nc1nc(C(C)(C)C)cs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594052	198120	1	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	350	4	1	3	5.5	CC(C)[C@H](C(=O)Nc1nc(C(C)(C)C)cs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46226271	198134	0	None	-	1	Human	4.1	pIC50	=	4.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	338	5	2	4	3.9	CC(C)[C@H](C(=O)Nc1ncc(C(=O)O)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594140	198134	0	None	-	1	Human	4.1	pIC50	=	4.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	338	5	2	4	3.9	CC(C)[C@H](C(=O)Nc1ncc(C(=O)O)s1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	2397905	198192	2	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	308	4	1	3	4.5	Cc1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)s1	10.1016/j.bmcl.2009.11.112
	CHEMBL594524	198192	2	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	308	4	1	3	4.5	Cc1cnc(NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)s1	10.1016/j.bmcl.2009.11.112
	4307629	200654	43	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	294	4	1	3	4.2	CC(C)C(C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL610463	200654	43	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	294	4	1	3	4.2	CC(C)C(C(=O)Nc1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	46225340	198074	0	None	-	1	Human	4.1	pIC50	=	4.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	308	4	0	3	4.2	CC(C)[C@H](C(=O)N(C)c1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL593733	198074	0	None	-	1	Human	4.1	pIC50	=	4.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	308	4	0	3	4.2	CC(C)[C@H](C(=O)N(C)c1nccs1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	70562873	115146	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	475	9	2	3	4.2	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)c1	10.1021/jm5012885
	CHEMBL3353526	115146	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	475	9	2	3	4.2	Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)c1	10.1021/jm5012885
	46226382	198275	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	338	3	1	3	4.8	O=C(Nc1ncc(F)s1)C1(c2ccc(Cl)cc2)CCCCC1	10.1016/j.bmcl.2009.11.112
	CHEMBL595000	198275	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	338	3	1	3	4.8	O=C(Nc1ncc(F)s1)C1(c2ccc(Cl)cc2)CCCCC1	10.1016/j.bmcl.2009.11.112
	46226338	198161	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	306	5	1	3	4.3	O=C(Nc1nccs1)[C@@H](CC1CC1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	CHEMBL594302	198161	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP productionAgonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production	ChEMBL	306	5	1	3	4.3	O=C(Nc1nccs1)[C@@H](CC1CC1)c1ccc(Cl)cc1	10.1016/j.bmcl.2009.11.112
	57520598	1782	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/jm5012885
	8417	1782	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/jm5012885
	CHEMBL3353541	1782	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/jm5012885
	DB15406	1782	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/jm5012885
	70566934	115157	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	487	9	2	4	4.3	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	CHEMBL3353538	115157	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	487	9	2	4	4.3	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3cc[nH]c3c2)CCN1C(=O)Cc1coc2ccccc12	10.1021/jm5012885
	70556909	115155	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	521	9	1	6	4.9	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3scnc3c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	CHEMBL3353535	115155	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationAntagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization	ChEMBL	521	9	1	6	4.9	CC1(C(=O)N(CCCC(=O)O)Cc2ccc3scnc3c2)CCN1C(=O)Cc1csc2ccccc12	10.1021/jm5012885
	1058	252	80	None	3	2	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	60	0	1	1	0.1	CC(=O)O	None
	176	252	80	None	3	2	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	60	0	1	1	0.1	CC(=O)O	None
	21980959	252	80	None	3	2	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	60	0	1	1	0.1	CC(=O)O	None
	4211	252	80	None	3	2	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	60	0	1	1	0.1	CC(=O)O	None
	CHEMBL539	252	80	None	3	2	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	60	0	1	1	0.1	CC(=O)O	None
	DB03166	252	80	None	3	2	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	60	0	1	1	0.1	CC(=O)O	None
	10107	3820	0	None	1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity in a BRET-based β-arrestin-2 recruitment assay.Agonist activity in a BRET-based β-arrestin-2 recruitment assay.	Guide to Pharmacology	442	4	1	5	5.0	O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C	30247908
	137321147	3820	0	None	1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity in a BRET-based β-arrestin-2 recruitment assay.Agonist activity in a BRET-based β-arrestin-2 recruitment assay.	Guide to Pharmacology	442	4	1	5	5.0	O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C	30247908
	10107	3820	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity in a cAMP inhibition assay.Agonist activity in a cAMP inhibition assay.	Guide to Pharmacology	442	4	1	5	5.0	O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C	30247908
	137321147	3820	0	None	1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity in a cAMP inhibition assay.Agonist activity in a cAMP inhibition assay.	Guide to Pharmacology	442	4	1	5	5.0	O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C	30247908
	6500	35	109	None	-47	2	Human	2.6	pEC50	=	2.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	100	1	1	1	0.9	OC(=O)C1(C)CC1	21220428
	81326	35	109	None	-47	2	Human	2.6	pEC50	=	2.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	100	1	1	1	0.9	OC(=O)C1(C)CC1	21220428
	CHEMBL4516837	35	109	None	-47	2	Human	2.6	pEC50	=	2.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	100	1	1	1	0.9	OC(=O)C1(C)CC1	21220428
	1061	2995	0	None	-50	2	Human	2.9	pEC50	=	2.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	102	3	1	1	1.3	CCCCC(=O)O	12496283
	7991	2995	0	None	-50	2	Human	2.9	pEC50	=	2.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	102	3	1	1	1.3	CCCCC(=O)O	12496283
	CHEMBL268736	2995	0	None	-50	2	Human	2.9	pEC50	=	2.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	102	3	1	1	1.3	CCCCC(=O)O	12496283
	DB02406	2995	0	None	-50	2	Human	2.9	pEC50	=	2.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	102	3	1	1	1.3	CCCCC(=O)O	12496283
	1059	739	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12496283
	1059	739	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12684041
	1059	739	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12711604
	1059	739	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	21220428
	264	739	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12496283
	264	739	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12684041
	264	739	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12711604
	264	739	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	21220428
	CHEMBL14227	739	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12496283
	CHEMBL14227	739	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12684041
	CHEMBL14227	739	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12711604
	CHEMBL14227	739	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	21220428
	DB03568	739	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12496283
	DB03568	739	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12684041
	DB03568	739	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	12711604
	DB03568	739	75	None	-7	3	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	2	1	1	0.9	CCCC(=O)O	21220428
	125468	2071	0	None	-	1	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	100	1	1	1	1.0	C/C(=C\C)/C(=O)O	21220428
	6499	2071	0	None	-	1	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	100	1	1	1	1.0	C/C(=C\C)/C(=O)O	21220428
	CHEMBL52416	2071	0	None	-	1	Human	3.8	pEC50	=	3.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	100	1	1	1	1.0	C/C(=C\C)/C(=O)O	21220428
	1058	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12496283
	1058	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12684041
	1058	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12711604
	1058	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	21220428
	176	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12496283
	176	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12684041
	176	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12711604
	176	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	21220428
	21980959	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12496283
	21980959	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12684041
	21980959	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12711604
	21980959	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	21220428
	4211	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12496283
	4211	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12684041
	4211	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12711604
	4211	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	21220428
	CHEMBL539	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12496283
	CHEMBL539	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12684041
	CHEMBL539	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12711604
	CHEMBL539	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	21220428
	DB03166	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12496283
	DB03166	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12684041
	DB03166	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	12711604
	DB03166	252	80	None	3	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	60	0	1	1	0.1	CC(=O)O	21220428
	1032	3136	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12496283
	1032	3136	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12684041
	1032	3136	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12711604
	1032	3136	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	21220428
	1062	3136	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12496283
	1062	3136	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12684041
	1062	3136	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12711604
	1062	3136	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	21220428
	CHEMBL14021	3136	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12496283
	CHEMBL14021	3136	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12684041
	CHEMBL14021	3136	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12711604
	CHEMBL14021	3136	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	21220428
	DB03766	3136	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12496283
	DB03766	3136	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12684041
	DB03766	3136	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	12711604
	DB03766	3136	71	None	-13	2	Human	4.0	pEC50	=	4.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	74	1	1	1	0.5	CCC(=O)O	21220428
	5803	390	15	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	18818303
	5803	390	15	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	21498659
	854189	390	15	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	18818303
	854189	390	15	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	21498659
	CHEMBL594671	390	15	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	18818303
	CHEMBL594671	390	15	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	294	4	1	3	4.2	CC([C@H](C(=O)Nc1nccs1)c1ccc(cc1)Cl)C	21498659
	3420	3392	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	312	4	1	3	4.3	CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C	18818303
	3420	3392	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	312	4	1	3	4.3	CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C	23066016
	46226252	3392	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	312	4	1	3	4.3	CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C	18818303
	46226252	3392	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	312	4	1	3	4.3	CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C	23066016
	CHEMBL594525	3392	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	312	4	1	3	4.3	CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C	18818303
	CHEMBL594525	3392	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	312	4	1	3	4.3	CC([C@H](C(=O)Nc1ncc(s1)F)c1ccc(cc1)Cl)C	23066016
	10107	3820	0	None	-1	2	Mouse	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	442	4	1	5	5.0	O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C	30247908
	137321147	3820	0	None	-1	2	Mouse	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	442	4	1	5	5.0	O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C	30247908
	6488	1001	0	None	-	1	Rat	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	474	8	1	4	5.9	OC(=O)CC(C(=O)N(c1scc(n1)c1cc(Cl)ccc1Cl)C1CC1)Cc1ccccc1	23589301
	67209274	1001	0	None	-	1	Rat	7.1	pEC50	=	7.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	474	8	1	4	5.9	OC(=O)CC(C(=O)N(c1scc(n1)c1cc(Cl)ccc1Cl)C1CC1)Cc1ccccc1	23589301
	1060	2058	69	None	-11	3	Human	3.5	pEC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	1	1	1	0.7	CC(C(=O)O)C	12711604
	6590	2058	69	None	-11	3	Human	3.5	pEC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	1	1	1	0.7	CC(C(=O)O)C	12711604
	CHEMBL108778	2058	69	None	-11	3	Human	3.5	pEC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	1	1	1	0.7	CC(C(=O)O)C	12711604
	DB02531	2058	69	None	-11	3	Human	3.5	pEC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	88	1	1	1	0.7	CC(C(=O)O)C	12711604
	12861	1176	20	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Determined in a cAMP assay measuring inhibition of forskolin-induced cAMP response in CHO cells expressing hFFA2Determined in a cAMP assay measuring inhibition of forskolin-induced cAMP response in CHO cells expressing hFFA2	Guide to Pharmacology	384	4	1	3	6.2	CC(C)(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=NC=C(S2)C3=CC=CC=C3	20005104
	46226294	1176	20	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Determined in a cAMP assay measuring inhibition of forskolin-induced cAMP response in CHO cells expressing hFFA2Determined in a cAMP assay measuring inhibition of forskolin-induced cAMP response in CHO cells expressing hFFA2	Guide to Pharmacology	384	4	1	3	6.2	CC(C)(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=NC=C(S2)C3=CC=CC=C3	20005104
	CHEMBL607315	1176	20	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Determined in a cAMP assay measuring inhibition of forskolin-induced cAMP response in CHO cells expressing hFFA2Determined in a cAMP assay measuring inhibition of forskolin-induced cAMP response in CHO cells expressing hFFA2	Guide to Pharmacology	384	4	1	3	6.2	CC(C)(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=NC=C(S2)C3=CC=CC=C3	20005104
	57520598	1782	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.	Guide to Pharmacology	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	25380412
	57520598	1782	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.	Guide to Pharmacology	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	26852904
	8417	1782	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.	Guide to Pharmacology	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	25380412
	8417	1782	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.	Guide to Pharmacology	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	26852904
	CHEMBL3353541	1782	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.	Guide to Pharmacology	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	25380412
	CHEMBL3353541	1782	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.	Guide to Pharmacology	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	26852904
	DB15406	1782	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.	Guide to Pharmacology	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	25380412
	DB15406	1782	27	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.Inhibition of sodium acetate-induced calcium flux <i>via</i> the FFA2 receptor.	Guide to Pharmacology	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	26852904
	12655	3821	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Measuring antagonism of agonist-induced GTPγS incorporation by liquid scintillation spectroscopy.Measuring antagonism of agonist-induced GTPγS incorporation by liquid scintillation spectroscopy.	Guide to Pharmacology	419	8	2	5	2.7	O=C(N[C@H](CC1=NN=NN1)CC2=CC=C(C(F)(F)F)C=C2)CC3=CC(OC)=CC=C3	None
	168433292	3821	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Measuring antagonism of agonist-induced GTPγS incorporation by liquid scintillation spectroscopy.Measuring antagonism of agonist-induced GTPγS incorporation by liquid scintillation spectroscopy.	Guide to Pharmacology	419	8	2	5	2.7	O=C(N[C@H](CC1=NN=NN1)CC2=CC=C(C(F)(F)F)C=C2)CC3=CC(OC)=CC=C3	None
	12655	3821	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Measuring inhibition of sodium propionate-induced intracellular calcium flux by TR-FRET.Measuring inhibition of sodium propionate-induced intracellular calcium flux by TR-FRET.	Guide to Pharmacology	419	8	2	5	2.7	O=C(N[C@H](CC1=NN=NN1)CC2=CC=C(C(F)(F)F)C=C2)CC3=CC(OC)=CC=C3	None
	168433292	3821	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Measuring inhibition of sodium propionate-induced intracellular calcium flux by TR-FRET.Measuring inhibition of sodium propionate-induced intracellular calcium flux by TR-FRET.	Guide to Pharmacology	419	8	2	5	2.7	O=C(N[C@H](CC1=NN=NN1)CC2=CC=C(C(F)(F)F)C=C2)CC3=CC(OC)=CC=C3	None
	53308747	797	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	399	7	2	2	4.1	OC(=O)C[C@@H](NC(=O)Cc1cccc(c1)Cl)Cc1ccc(cc1)C(F)(F)F	23066016
	6487	797	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	399	7	2	2	4.1	OC(=O)C[C@@H](NC(=O)Cc1cccc(c1)Cl)Cc1ccc(cc1)C(F)(F)F	23066016

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	137633536	155754	0	None	-	0	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at human FFA2 receptor by FLIPR assayAgonist activity at human FFA2 receptor by FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	CHEMBL4065397	155754	0	None	-	0	Human	4.6	pEC50	=	4.6	Binding	Agonist activity at human FFA2 receptor by FLIPR assayAgonist activity at human FFA2 receptor by FLIPR assay	ChEMBL	368	7	1	3	4.6	COc1ccc(C(F)(F)F)cc1COc1ccc(CCC(=O)O)cc1C	10.1016/j.bmcl.2017.01.034
	57520598	1782	27	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Antagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometryAntagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometry	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/jm5012885
	8417	1782	27	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Antagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometryAntagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometry	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/jm5012885
	CHEMBL3353541	1782	27	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Antagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometryAntagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometry	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/jm5012885
	DB15406	1782	27	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Antagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometryAntagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometry	ChEMBL	484	8	1	4	5.1	OC(=O)CCCN(C(=O)[C@@]1(C)CCN1C(=O)c1csc2c1cccc2)Cc1cccc(c1)Cl	10.1021/jm5012885
	145951537	162159	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	537	10	1	7	6.0	COc1ccc(-c2ccc(Cl)cc2-c2csc(N(C(=O)[C@@H](CC(=O)O)Cc3ccco3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	CHEMBL4170829	162159	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	537	10	1	7	6.0	COc1ccc(-c2ccc(Cl)cc2-c2csc(N(C(=O)[C@@H](CC(=O)O)Cc3ccco3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	145957346	161421	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	419	5	1	4	4.7	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4159019	161421	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	419	5	1	4	4.7	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	67209751	161620	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	505	10	1	6	6.0	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC3CCCC3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	CHEMBL4162307	161620	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	505	10	1	6	6.0	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC3CCCC3)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	117898644	162547	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	515	10	1	7	5.7	CC(C)C[C@H](CC(=O)O)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4177037	162547	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	515	10	1	7	5.7	CC(C)C[C@H](CC(=O)O)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	53302677	162297	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4172928	162297	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	474	8	1	4	5.9	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2cc(Cl)ccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	67209297	162248	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	422	7	1	5	4.3	CN(C(=O)[C@@H](CC(=O)O)CC1CCOCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4172349	162248	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	422	7	1	5	4.3	CN(C(=O)[C@@H](CC(=O)O)CC1CCOCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	138319694	162524	23	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4176503	162524	23	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	442	4	1	5	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	117898634	161845	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	479	10	1	6	5.5	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC(C)C)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	CHEMBL4165748	161845	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	479	10	1	6	5.5	COc1ccc(-c2ccccc2-c2csc(N(C(=O)[C@@H](CC(=O)O)CC(C)C)C3CC3)n2)cn1	10.1016/j.bmc.2018.09.015
	67209218	162330	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	406	7	1	4	5.1	CN(C(=O)[C@@H](CC(=O)O)CC1CCCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4173387	162330	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	406	7	1	4	5.1	CN(C(=O)[C@@H](CC(=O)O)CC1CCCC1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	145951986	162154	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4170748	162154	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	453	5	1	4	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CS[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	145953670	162012	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	424	4	1	4	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4168456	162012	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	424	4	1	4	5.0	Cc1noc(C)c1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	67210172	161908	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	440	8	1	4	5.3	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2ccccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4166818	161908	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	440	8	1	4	5.3	O=C(O)C[C@@H](Cc1ccccc1)C(=O)N(c1nc(-c2ccccc2Cl)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	67258265	162178	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	435	5	1	3	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4171128	162178	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	435	5	1	3	5.4	COc1ccccc1-c1ccc(C(=O)N2[C@H](C(=O)O)CC[C@@H]2c2ccccc2Cl)cc1	10.1021/acs.jmedchem.8b00855
	117898651	162343	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	541	10	1	7	6.2	O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	CHEMBL4173663	162343	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	541	10	1	7	6.2	O=C(O)C[C@@H](CC1CCCC1)C(=O)N(c1nc(-c2ccccc2-c2ccc(-n3cccn3)nc2)cs1)C1CC1	10.1016/j.bmc.2018.09.015
	46235794	162385	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	CHEMBL4174307	162385	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting methodDisplacement of [3H]ES227703 from human FFA2R expressed in CHOK1 cells after 60 mins by TopCount scintillation counting method	ChEMBL	414	7	1	4	4.8	CN(C(=O)[C@@H](CC(=O)O)Cc1ccccc1)c1nc(-c2ccccc2Cl)cs1	10.1016/j.bmc.2018.09.015
	145953626	161961	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	CHEMBL4167577	161961	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometryDisplacement of [3H]-GLPG0974 from human FFA2 expressed in Flp-InT-REx 293 cell membranes after 2 hrs by liquid scintillation spectrometry	ChEMBL	423	4	1	3	5.3	O=C(O)[C@@H]1CS[C@H](c2ccccc2Cl)N1C(=O)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.8b00855
	10107	3820	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for hFFA2.Binding affinity for hFFA2.	Guide to Pharmacology	442	4	1	5	5.0	O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C	30247908
	137321147	3820	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for hFFA2.Binding affinity for hFFA2.	Guide to Pharmacology	442	4	1	5	5.0	O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C	30247908

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Ligand source activities (1 row/activity)