GPCRdb

Ligand source activities (1 row/activity)

Potency
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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	11715531	95472	21	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	5	2	4	1.9	C=CCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL236013	95472	21	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	5	2	4	1.9	C=CCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	28400380	96692	4	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	5	2	3	2.0	CCCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237945	96692	4	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	5	2	3	2.0	CCCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11415838	143135	0	None	-1	2	Human	5.0	pEC50	=	5.0	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	316	2	1	4	2.6	Cc1sc(C2(C)OC(C(=O)O)=CC2=O)cc1Br	10.1021/jm070022x
	CHEMBL373484	143135	0	None	-1	2	Human	5.0	pEC50	=	5.0	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	316	2	1	4	2.6	Cc1sc(C2(C)OC(C(=O)O)=CC2=O)cc1Br	10.1021/jm070022x
	28400046	96585	3	None	32	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	2	3	1.8	CC(C)CNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237737	96585	3	None	32	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	2	3	1.8	CC(C)CNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	10198518	80312	30	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	231	2	1	4	2.2	O=C(O)c1ccc2c(c1)nnn2C1CCCC1	10.1021/jm051099t
	CHEMBL201724	80312	30	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	231	2	1	4	2.2	O=C(O)c1ccc2c(c1)nnn2C1CCCC1	10.1021/jm051099t
	24955646	64808	0	None	-186	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	310	5	1	4	2.9	CC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1	10.1021/ml100251u
	CHEMBL1672639	64808	0	None	-186	4	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	310	5	1	4	2.9	CC1(CCCc2cc(=O)oc3nc(C(F)F)[nH]c(=O)c23)CC1	10.1021/ml100251u
	1591	6919	63	None	-33	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1016/j.bmcl.2007.07.101
	6485181	6919	63	None	-33	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1016/j.bmcl.2007.07.101
	CHEMBL428730	6919	63	None	-33	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	168	4	2	2	1.5	CCCCc1cc(n[nH]1)C(=O)O	10.1016/j.bmcl.2007.07.101
	28400196	97027	19	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	266	7	1	4	2.9	CCCN(CCC)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL238376	97027	19	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	266	7	1	4	2.9	CCCN(CCC)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	44433532	159188	0	None	-16	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	2	2	4	0.3	CCc1[nH]nc(-c2nnn[nH]2)c1F	10.1016/j.bmcl.2007.07.101
	CHEMBL397055	159188	0	None	-16	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	2	2	4	0.3	CCc1[nH]nc(-c2nnn[nH]2)c1F	10.1016/j.bmcl.2007.07.101
	11219885	90237	0	None	-3	2	Human	4.9	pEC50	=	4.9	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	286	2	1	3	2.5	CC1(c2cccc(C(F)(F)F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL220001	90237	0	None	-3	2	Human	4.9	pEC50	=	4.9	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	286	2	1	3	2.5	CC1(c2cccc(C(F)(F)F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	15604642	82029	0	None	-323	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	250	3	2	4	0.8	CC(C)CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036948	82029	0	None	-323	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	250	3	2	4	0.8	CC(C)CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	43131474	158420	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	4	2	3	2.2	CC(C)C(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL396382	158420	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	4	2	3	2.2	CC(C)C(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11961288	203489	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	313	6	2	4	3.4	O=C(O)c1cc(N(Cc2ccccc2)Cc2ccsc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL564914	203489	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	313	6	2	4	3.4	O=C(O)c1cc(N(Cc2ccccc2)Cc2ccsc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	15604637	82035	0	None	-70	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	262	4	2	4	0.9	O=c1[nH]c(=O)c2c(CCCC3CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036955	82035	0	None	-70	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	262	4	2	4	0.9	O=c1[nH]c(=O)c2c(CCCC3CC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	11380943	90234	1	None	-20	2	Human	4.9	pEC50	=	4.9	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL219980	90234	1	None	-20	2	Human	4.9	pEC50	=	4.9	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	45269912	202689	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	O=C(O)c1cc(N(Cc2ccsc2)Cc2cccs2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL559204	202689	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	O=C(O)c1cc(N(Cc2ccsc2)Cc2cccs2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11687485	96824	4	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	254	6	2	5	1.7	COCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL238164	96824	4	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	254	6	2	5	1.7	COCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11483496	6914	0	None	-14	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm800896z
	1589	6914	0	None	-14	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm800896z
	CHEMBL375493	6914	0	None	-14	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm800896z
	11483496	6914	0	None	-14	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1589	6914	0	None	-14	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL375493	6914	0	None	-14	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	28400406	96693	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	6	2	3	2.4	CCCCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237946	96693	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	6	2	3	2.4	CCCCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11528819	152284	23	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	2	4	2.5	CCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL391473	152284	23	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	2	4	2.5	CCC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	2829816	95522	54	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	6	2	4	2.5	CCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL236219	95522	54	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	6	2	4	2.5	CCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	17965902	96589	4	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	242	3	2	3	2.0	O=C(O)c1ccc(NC(=O)c2ccccc2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL237739	96589	4	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	242	3	2	3	2.0	O=C(O)c1ccc(NC(=O)c2ccccc2)nc1	10.1016/j.bmcl.2007.09.058
	11379903	91046	0	None	-6	2	Human	4.8	pEC50	=	4.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL221282	91046	0	None	-6	2	Human	4.8	pEC50	=	4.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	43271548	97031	4	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	1	3	1.6	CCCN(C)c1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL238387	97031	4	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	1	3	1.6	CCCN(C)c1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11379903	91046	0	None	-6	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL221282	91046	0	None	-6	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	11379903	91046	0	None	-6	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm800896z
	CHEMBL221282	91046	0	None	-6	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm800896z
	11436345	6931	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1599	6931	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL424938	6931	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	11218626	91667	0	None	1	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1csc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	CHEMBL223623	91667	0	None	1	2	Human	5.8	pEC50	=	5.8	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1csc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	13153555	100638	27	None	-42	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	5	2	2	1.8	CCCCCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.07.101
	CHEMBL247921	100638	27	None	-42	2	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	182	5	2	2	1.8	CCCCCc1cc(C(=O)O)[nH]n1	10.1016/j.bmcl.2007.07.101
	15605571	82010	2	None	-23	5	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	236	3	2	4	0.5	CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	CHEMBL2036813	82010	2	None	-23	5	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	236	3	2	4	0.5	CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12	10.1021/ml200243g
	11470798	144745	1	None	-2	2	Human	4.7	pEC50	=	4.7	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)c(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL376419	144745	1	None	-2	2	Human	4.7	pEC50	=	4.7	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)c(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	283475	96580	118	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	196	3	2	4	1.3	CNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL237731	96580	118	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	196	3	2	4	1.3	CNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11528793	95477	4	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	236	4	2	4	2.3	O=C(O)c1ccc(NC2CCC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL236028	95477	4	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	236	4	2	4	2.3	O=C(O)c1ccc(NC2CCC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	10263467	147672	2	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	235	4	1	5	1.3	COCC(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL382096	147672	2	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	235	4	1	5	1.3	COCC(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	2776549	80166	82	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	177	1	1	4	0.7	Cn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL201513	80166	82	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	177	1	1	4	0.7	Cn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	3684804	97025	48	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	3	1	4	1.4	CN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL238374	97025	48	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	3	1	4	1.4	CN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11322738	143544	1	None	-13	2	Human	4.7	pEC50	=	4.7	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	252	2	1	3	2.1	CC1(c2cccc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL374111	143544	1	None	-13	2	Human	4.7	pEC50	=	4.7	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	252	2	1	3	2.1	CC1(c2cccc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	3729086	152375	58	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	4	2	4	1.7	CCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL391547	152375	58	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	4	2	4	1.7	CCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	10465474	147235	27	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	203	2	1	4	1.5	O=C(O)c1ccc2c(c1)nnn2C1CC1	10.1021/jm051099t
	CHEMBL380939	147235	27	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	203	2	1	4	1.5	O=C(O)c1ccc2c(c1)nnn2C1CC1	10.1021/jm051099t
	11322761	148384	1	None	-1	2	Human	4.6	pEC50	=	4.6	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)cc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL385103	148384	1	None	-1	2	Human	4.6	pEC50	=	4.6	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2ccc(F)cc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	3824366	96283	57	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	258	4	2	4	3.0	O=C(O)c1ccc(Nc2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	3953363	96283	57	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	258	4	2	4	3.0	O=C(O)c1ccc(Nc2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL237296	96283	57	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	258	4	2	4	3.0	O=C(O)c1ccc(Nc2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	45269046	203166	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	O=C(O)c1cc(N(Cc2cccs2)Cc2cccs2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL562675	203166	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	O=C(O)c1cc(N(Cc2cccs2)Cc2cccs2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11708383	95294	36	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	4	2	4	2.1	CC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL235144	95294	36	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	4	2	4	2.1	CC(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	10421571	81000	2	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	235	5	1	5	1.2	CCOCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202351	81000	2	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	235	5	1	5	1.2	CCOCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	10398515	142069	33	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	1	1	4	1.9	CC(C)(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL372727	142069	33	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	1	1	4	1.9	CC(C)(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	28400056	159002	1	None	74	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	5	2	3	2.4	CCC(CC)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL396879	159002	1	None	74	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	208	5	2	3	2.4	CCC(CC)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11276453	91651	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1ccc(C2(C)OC(C(=O)O)=CC2=O)s1	10.1021/jm070022x
	CHEMBL223566	91651	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1ccc(C2(C)OC(C(=O)O)=CC2=O)s1	10.1021/jm070022x
	11492560	95293	5	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	7	2	4	2.9	CCCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL235141	95293	5	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	7	2	4	2.9	CCCCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	10014206	79815	3	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	233	5	1	4	2.3	CCCCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL201048	79815	3	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	233	5	1	4	2.3	CCCCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	11715556	6908	40	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	10.1016/j.bmcl.2007.09.058
	5801	6908	40	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	10.1016/j.bmcl.2007.09.058
	CHEMBL236011	6908	40	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	10.1016/j.bmcl.2007.09.058
	44250176	7915	0	None	2951	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	10.1016/j.bmcl.2009.05.108
	5800	7915	0	None	2951	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	10.1016/j.bmcl.2009.05.108
	CHEMBL564300	7915	0	None	2951	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	10.1016/j.bmcl.2009.05.108
	51346919	64617	6	None	-100	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	296	5	1	4	2.5	O=c1cc(CCCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	CHEMBL1671877	64617	6	None	-100	4	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	296	5	1	4	2.5	O=c1cc(CCCC2CC2)c2c(=O)[nH]c(C(F)F)nc2o1	10.1021/ml100251u
	1595	7047	49	None	-4	2	Human	5.5	pEC50	=	5.5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	51576	7047	49	None	-4	2	Human	5.5	pEC50	=	5.5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	CHEMBL278488	7047	49	None	-4	2	Human	5.5	pEC50	=	5.5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	10353934	139939	2	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	233	4	1	4	2.5	CCC(CC)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL370386	139939	2	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	233	4	1	4	2.5	CCC(CC)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	10422270	80147	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	251	5	1	5	1.9	CCSCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL201409	80147	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	251	5	1	5	1.9	CCSCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	4992776	97015	33	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	4	2	4	1.9	O=C(O)c1ccc(NC2CC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL238358	97015	33	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	4	2	4	1.9	O=C(O)c1ccc(NC2CC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	11565047	153996	25	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	250	4	2	4	2.6	O=C(O)c1ccc(NC2CCCC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL392830	153996	25	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	250	4	2	4	2.6	O=C(O)c1ccc(NC2CCCC2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	2942936	156643	19	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	266	5	2	5	1.9	O=C(O)c1ccc(NCC2CCCO2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL394906	156643	19	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	266	5	2	5	1.9	O=C(O)c1ccc(NCC2CCCO2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	44434363	175750	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	286	4	2	4	2.5	O=C(O)c1ccc(NC(=O)c2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	CHEMBL439028	175750	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	286	4	2	4	2.5	O=C(O)c1ccc(NC(=O)c2ccccc2)c([N+](=O)[O-])c1	10.1016/j.bmcl.2007.09.058
	10330955	175884	3	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	217	2	1	4	1.9	O=C(O)c1ccc2c(c1)nnn2C1CCC1	10.1021/jm051099t
	CHEMBL440041	175884	3	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	217	2	1	4	1.9	O=C(O)c1ccc2c(c1)nnn2C1CCC1	10.1021/jm051099t
	10398583	80744	13	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	221	4	1	5	0.8	COCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202157	80744	13	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	221	4	1	5	0.8	COCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	28400038	95384	36	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	178	3	2	3	1.4	O=C(O)c1ccc(NC2CC2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL235615	95384	36	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	178	3	2	3	1.4	O=C(O)c1ccc(NC2CC2)nc1	10.1016/j.bmcl.2007.09.058
	44433529	95311	0	None	5	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	176	2	2	4	0.5	c1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	CHEMBL235230	95311	0	None	5	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	176	2	2	4	0.5	c1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	2771812	96586	53	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	214	3	2	3	2.5	O=C(O)c1ccc(Nc2ccccc2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL237738	96586	53	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	214	3	2	3	2.5	O=C(O)c1ccc(Nc2ccccc2)nc1	10.1016/j.bmcl.2007.09.058
	43187344	97029	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	5	2	4	1.2	COCC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL238385	97029	1	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	210	5	2	4	1.2	COCC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11817645	91681	1	None	-12	2	Human	4.5	pEC50	=	4.5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2cc(F)cc(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL223700	91681	1	None	-12	2	Human	4.5	pEC50	=	4.5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2cc(F)cc(F)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	10013684	80804	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	3	1	4	2.1	CCC(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202206	80804	2	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	3	1	4	2.1	CCC(C)n1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	4712703	148000	44	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	204	2	1	3	2.3	CC(C)n1cnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL382863	148000	44	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	204	2	1	3	2.3	CC(C)n1cnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	44433529	95311	0	None	5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	176	2	2	4	0.5	c1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	CHEMBL235230	95311	0	None	5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	176	2	2	4	0.5	c1c(-c2nnn[nH]2)n[nH]c1C1CC1	10.1016/j.bmcl.2007.07.101
	11322762	144380	1	None	-5	2	Human	4.4	pEC50	=	4.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2c(F)cccc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL375625	144380	1	None	-5	2	Human	4.4	pEC50	=	4.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	254	2	1	3	1.7	CC1(c2c(F)cccc2F)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	43085192	96206	1	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	5	2	4	2.7	CC(C)C(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL237077	96206	1	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	5	2	4	2.7	CC(C)C(C)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11483496	6914	0	None	-14	2	Human	6.4	pEC50	=	6.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1589	6914	0	None	-14	2	Human	6.4	pEC50	=	6.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL375493	6914	0	None	-14	2	Human	6.4	pEC50	=	6.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	Brc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	11311474	172561	0	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2ccc(Cl)s2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL424750	172561	0	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2ccc(Cl)s2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	43187332	158999	2	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	2	3	2.0	CCC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL396878	158999	2	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	194	4	2	3	2.0	CCC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	1447952	96584	7	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	206	3	2	3	2.1	O=C(O)c1ccc(NC2CCCC2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL237735	96584	7	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	206	3	2	3	2.1	O=C(O)c1ccc(NC2CCCC2)nc1	10.1016/j.bmcl.2007.09.058
	11744994	96581	26	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	166	3	2	3	1.2	CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237732	96581	26	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	166	3	2	3	1.2	CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	1597	8746	80	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	10.1021/jm051099t
	2736690	8746	80	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	10.1021/jm051099t
	CHEMBL381638	8746	80	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	10.1021/jm051099t
	45268162	203018	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	235	6	2	3	1.7	O=C(O)c1cc(N(CC2CC2)CC2CC2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL561720	203018	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	235	6	2	3	1.7	O=C(O)c1cc(N(CC2CC2)CC2CC2)[nH]n1	10.1016/j.bmcl.2009.05.108
	28399894	156066	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	178	4	2	3	1.4	C=CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2009.05.108
	CHEMBL394468	156066	2	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	178	4	2	3	1.4	C=CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2009.05.108
	11324121	91441	0	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	CC1(c2cc(Br)cs2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL222472	91441	0	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	302	2	1	4	2.3	CC1(c2cc(Br)cs2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	776421	96703	108	None	-30	2	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	154	2	2	2	1.2	CC(C)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL238002	96703	108	None	-30	2	Human	4.4	pEC50	=	4.4	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	154	2	2	2	1.2	CC(C)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2007.07.101
	1595	7047	49	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	51576	7047	49	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	CHEMBL278488	7047	49	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	1595	7047	49	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	51576	7047	49	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	CHEMBL278488	7047	49	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm070022x
	11183678	91547	1	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	224	2	1	4	1.5	CC1(c2ccsc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL223140	91547	1	None	-1	2	Human	5.4	pEC50	=	5.4	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	224	2	1	4	1.5	CC1(c2ccsc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	1595	7047	49	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayAgonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmcl.2009.05.108
	51576	7047	49	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayAgonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmcl.2009.05.108
	CHEMBL278488	7047	49	None	-4	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayAgonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmcl.2009.05.108
	11992587	202277	1	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	183	4	3	3	1.3	CCC(C)Nc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	CHEMBL553415	202277	1	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	183	4	3	3	1.3	CCC(C)Nc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	11148966	7906	4	None	4	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	10.1021/jm070022x
	1598	7906	4	None	4	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	10.1021/jm070022x
	CHEMBL436301	7906	4	None	4	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	10.1021/jm070022x
	11380943	90234	1	None	-20	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL219980	90234	1	None	-20	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	296	2	1	3	2.2	CC1(c2cccc(Br)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	11436345	6931	0	None	-1	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	1599	6931	0	None	-1	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	CHEMBL424938	6931	0	None	-1	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	10.1021/jm070022x
	9971057	81078	4	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	283	4	1	5	2.2	COc1cccc(Cn2nnc3cc(C(=O)O)ccc32)c1	10.1021/jm051099t
	CHEMBL202427	81078	4	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	283	4	1	5	2.2	COc1cccc(Cn2nnc3cc(C(=O)O)ccc32)c1	10.1021/jm051099t
	28399946	96582	8	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	180	4	2	3	1.6	CCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237733	96582	8	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	180	4	2	3	1.6	CCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11739420	91532	0	None	-12	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	344	2	1	3	2.1	CC1(c2cccc(I)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL223013	91532	0	None	-12	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	344	2	1	3	2.1	CC1(c2cccc(I)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	11413114	144397	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	208	2	1	3	1.4	CC1(C2=CCCC2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL375754	144397	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	208	2	1	3	1.4	CC1(C2=CCCC2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	43271417	97026	1	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	1	4	2.1	CCCN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL238375	97026	1	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	1	4	2.1	CCCN(C)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	11992688	202518	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	335	8	2	3	3.4	O=C(O)c1cc(N(CCc2ccccc2)CCc2ccccc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL557298	202518	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	335	8	2	3	3.4	O=C(O)c1cc(N(CCc2ccccc2)CCc2ccccc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11514348	159868	6	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	6	2	4	2.9	CCC(CC)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL397616	159868	6	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	252	6	2	4	2.9	CCC(CC)Nc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	4738197	158084	39	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	240	6	2	5	1.4	COCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL396073	158084	39	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	240	6	2	5	1.4	COCCNc1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	653819	148039	50	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	245	2	1	4	2.6	O=C(O)c1ccc2c(c1)nnn2C1CCCCC1	10.1021/jm051099t
	CHEMBL383099	148039	50	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	245	2	1	4	2.6	O=C(O)c1ccc2c(c1)nnn2C1CCCCC1	10.1021/jm051099t
	59343664	82031	0	None	-29	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	272	4	2	4	0.8	O=c1[nH]c(=O)c2c(CCCC(F)F)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036951	82031	0	None	-29	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	272	4	2	4	0.8	O=c1[nH]c(=O)c2c(CCCC(F)F)cc(=O)oc2[nH]1	10.1021/ml200243g
	43187366	97030	5	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	4	2	4	1.4	O=C(O)c1ccc(NCC2CCCO2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL238386	97030	5	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	4	2	4	1.4	O=C(O)c1ccc(NCC2CCCO2)nc1	10.1016/j.bmcl.2007.09.058
	28400003	156068	37	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	180	3	2	3	1.6	CC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL394469	156068	37	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	180	3	2	3	1.6	CC(C)Nc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	11184165	90229	0	None	-5	2	Human	5.2	pEC50	=	5.2	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	246	3	1	3	2.0	CCc1cccc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	CHEMBL219950	90229	0	None	-5	2	Human	5.2	pEC50	=	5.2	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	246	3	1	3	2.0	CCc1cccc(C2(C)OC(C(=O)O)=CC2=O)c1	10.1021/jm070022x
	2833647	156646	24	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	1	4	2.1	CCN(CC)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	CHEMBL394907	156646	24	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	238	5	1	4	2.1	CCN(CC)c1ccc(C(=O)O)cc1[N+](=O)[O-]	10.1016/j.bmcl.2007.09.058
	16775596	96386	3	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	6	1	3	2.4	CCCN(CCC)c1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL237525	96386	3	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	222	6	1	3	2.4	CCCN(CCC)c1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	59304608	82034	0	None	-67	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	262	3	2	4	0.9	O=c1[nH]c(=O)c2c(CCC3CCC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	CHEMBL2036954	82034	0	None	-67	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	262	3	2	4	0.9	O=c1[nH]c(=O)c2c(CCC3CCC3)cc(=O)oc2[nH]1	10.1021/ml200243g
	11992588	202228	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	197	5	3	3	1.7	CCCC(C)Nc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	CHEMBL552399	202228	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	197	5	3	3	1.7	CCCC(C)Nc1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	11379903	91046	0	None	-6	2	Human	6.2	pEC50	=	6.2	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL221282	91046	0	None	-6	2	Human	6.2	pEC50	=	6.2	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	258	2	1	4	2.2	CC1(c2csc(Cl)c2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	10331019	81188	31	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	4	1	4	1.9	CCCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202586	81188	31	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	219	4	1	4	1.9	CCCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	28399894	156066	2	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	178	4	2	3	1.4	C=CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL394468	156066	2	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	178	4	2	3	1.4	C=CCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	44434380	96385	21	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	192	3	2	3	1.7	O=C(O)c1ccc(NC2CCC2)nc1	10.1016/j.bmcl.2007.09.058
	CHEMBL237524	96385	21	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	192	3	2	3	1.7	O=C(O)c1ccc(NC2CCC2)nc1	10.1016/j.bmcl.2007.09.058
	44433528	154300	0	None	10	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	178	3	2	4	0.5	CCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL393064	154300	0	None	10	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	178	3	2	4	0.5	CCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	22271415	95299	57	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	152	2	2	3	0.8	CNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL235168	95299	57	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	152	2	2	3	0.8	CNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	10058774	81192	28	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	3	1	4	1.5	CCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL202614	81192	28	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	205	3	1	4	1.5	CCCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	44433530	154302	0	None	2	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	192	4	2	4	0.9	CCCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	CHEMBL393065	154302	0	None	2	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	192	4	2	4	0.9	CCCCc1cc(-c2nnn[nH]2)n[nH]1	10.1016/j.bmcl.2007.07.101
	117629482	9599	140	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	1588	9599	140	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	1594	9599	140	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	2835	9599	140	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	938	9599	140	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	CHEMBL573	9599	140	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	DB00627	9599	140	None	-26	4	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayAgonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay	ChEMBL	123	1	1	2	0.8	OC(=O)c1cccnc1	10.1016/j.bmcl.2007.07.101
	11992592	202810	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	211	6	2	3	1.7	CCCN(CCC)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	CHEMBL560254	202810	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	211	6	2	3	1.7	CCCN(CCC)c1cc(C(=O)O)n[nH]1	10.1016/j.bmcl.2009.05.108
	11992591	203049	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	307	6	2	3	3.3	O=C(O)c1cc(N(Cc2ccccc2)Cc2ccccc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL561920	203049	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	307	6	2	3	3.3	O=C(O)c1cc(N(Cc2ccccc2)Cc2ccccc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11992790	201971	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	343	6	2	3	3.6	O=C(O)c1cc(N(Cc2ccccc2F)Cc2ccccc2F)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL550563	201971	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	343	6	2	3	3.6	O=C(O)c1cc(N(Cc2ccccc2F)Cc2ccccc2F)[nH]n1	10.1016/j.bmcl.2009.05.108
	2103992	175905	46	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	191	2	1	4	1.1	CCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	CHEMBL440217	175905	46	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	191	2	1	4	1.1	CCn1nnc2cc(C(=O)O)ccc21	10.1021/jm051099t
	45269904	203511	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	287	6	2	5	2.5	O=C(O)c1cc(N(Cc2ccoc2)Cc2ccoc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	CHEMBL565055	203511	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayAgonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay	ChEMBL	287	6	2	5	2.5	O=C(O)c1cc(N(Cc2ccoc2)Cc2ccoc2)[nH]n1	10.1016/j.bmcl.2009.05.108
	11608532	80069	31	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	253	3	1	4	2.2	O=C(O)c1ccc2c(c1)nnn2Cc1ccccc1	10.1021/jm051099t
	CHEMBL201278	80069	31	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Agonistic activity at GPR109b by cAMP whole cell assayAgonistic activity at GPR109b by cAMP whole cell assay	ChEMBL	253	3	1	4	2.2	O=C(O)c1ccc2c(c1)nnn2Cc1ccccc1	10.1021/jm051099t
	28400019	95341	9	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	196	5	2	4	0.8	COCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	CHEMBL235394	95341	9	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assayAgonist activity at human GPR109b receptor transfected in CHOK1 cells assessed as reversal of forskolin-induced cAMP elevating effect by whole cell assay	ChEMBL	196	5	2	4	0.8	COCCNc1ccc(C(=O)O)cn1	10.1016/j.bmcl.2007.09.058
	56950369	10332	13	None	-47	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	8469	10332	13	None	-47	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	CHEMBL2036958	10332	13	None	-47	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	DB12433	10332	13	None	-47	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR109bAgonist activity at human GPR109b	ChEMBL	276	4	2	4	1.3	O=c1cc(CCCC2(C)CC2)c2c(o1)[nH]c(=O)[nH]c2=O	10.1021/ml200243g
	11264843	144398	1	None	-1	2	Human	5.0	pEC50	=	5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	236	2	1	3	1.6	CC1(c2ccc(F)cc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	CHEMBL375762	144398	1	None	-1	2	Human	5.0	pEC50	=	5	Functional	Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationActivity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation	ChEMBL	236	2	1	3	1.6	CC1(c2ccc(F)cc2)OC(C(=O)O)=CC1=O	10.1021/jm070022x
	1595	7047	49	None	-4	2	Human	5.5	pIC50	=	5.5	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	51576	7047	49	None	-4	2	Human	5.5	pIC50	=	5.5	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	CHEMBL278488	7047	49	None	-4	2	Human	5.5	pIC50	=	5.5	Functional	Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionActivity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1021/jm800896z
	117629482	9599	140	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	1588	9599	140	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	1594	9599	140	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	2835	9599	140	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	938	9599	140	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	CHEMBL573	9599	140	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	DB00627	9599	140	None	-26	4	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	123	1	1	2	0.8	OC(=O)c1cccnc1	None
	5798	8284	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	6923517	8284	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	9060	8284	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	CHEMBL292303	8284	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	DB03225	8284	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	204	3	3	2	1.1	OC(=O)[C@@H](Cc1c[nH]c2c1cccc2)N	19237584
	5797	8257	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	6919011	8257	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	71567	8257	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	CHEMBL379630	8257	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	DB02556	8257	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	165	3	2	2	0.6	N[C@@H](C(=O)O)Cc1ccccc1	19237584
	11367166	6889	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCC[C@@H](CC(=O)O)O	19561068
	2933	6889	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCC[C@@H](CC(=O)O)O	19561068
	117629482	9599	140	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	1588	9599	140	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	1594	9599	140	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	2835	9599	140	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	938	9599	140	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	CHEMBL573	9599	140	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	DB00627	9599	140	None	-26	4	Human	5.3	pEC50	=	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	123	1	1	2	0.8	OC(=O)c1cccnc1	12522134
	5796	6855	77	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCCCC(C(=O)O)O	19561068
	94180	6855	77	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCCCC(C(=O)O)O	19561068
	CHEMBL4447980	6855	77	None	-	1	Human	5.4	pEC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	160	6	2	2	1.4	CCCCCCC(C(=O)O)O	19561068
	1152206	8222	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	208	4	3	4	0.3	OC(=O)[C@@H](CC(=O)c1ccccc1N)N	19237584
	5799	8222	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	208	4	3	4	0.3	OC(=O)[C@@H](CC(=O)c1ccccc1N)N	19237584
	6971244	8222	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	208	4	3	4	0.3	OC(=O)[C@@H](CC(=O)c1ccccc1N)N	19237584
	CHEMBL1233899	8222	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	208	4	3	4	0.3	OC(=O)[C@@H](CC(=O)c1ccccc1N)N	19237584
	1597	8746	80	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	16480258
	2736690	8746	80	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	16480258
	CHEMBL381638	8746	80	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	205	2	1	4	1.7	OC(=O)c1ccc2c(c1)nnn2C(C)C	16480258
	12418	8258	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	166	3	2	2	0.7	C1=CC=C(C=C1)C[C@@H](C(=O)O)O	31120900
	444718	8258	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	166	3	2	2	0.7	C1=CC=C(C=C1)C[C@@H](C(=O)O)O	31120900
	DB02494	8258	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	166	3	2	2	0.7	C1=CC=C(C=C1)C[C@@H](C(=O)O)O	31120900
	11715556	6908	40	None	-	1	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	17931863
	5801	6908	40	None	-	1	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	17931863
	CHEMBL236011	6908	40	None	-	1	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	224	5	2	4	2.1	CCCNc1ccc(cc1[N+](=O)[O-])C(=O)O	17931863
	44250176	7915	0	None	2951	2	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	19524438
	5800	7915	0	None	2951	2	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	19524438
	CHEMBL564300	7915	0	None	2951	2	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	319	6	2	5	3.4	OC(=O)c1n[nH]c(c1)N(Cc1cscc1)Cc1cscc1	19524438
	1595	7047	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	12522134
	1595	7047	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	15929991
	1595	7047	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	16389067
	1595	7047	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	17358052
	51576	7047	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	12522134
	51576	7047	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	15929991
	51576	7047	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	16389067
	51576	7047	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	17358052
	CHEMBL278488	7047	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	12522134
	CHEMBL278488	7047	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	15929991
	CHEMBL278488	7047	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	16389067
	CHEMBL278488	7047	49	None	-4	2	Human	5.0	pEC50	None	5.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	17358052
	11148966	7906	4	None	4	2	Human	5.3	pEC50	None	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	17358052
	1598	7906	4	None	4	2	Human	5.3	pEC50	None	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	17358052
	CHEMBL436301	7906	4	None	4	2	Human	5.3	pEC50	None	5.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	232	3	1	3	1.9	CCC1(OC(=CC1=O)C(=O)O)c1ccccc1	17358052
	11436345	6931	0	None	-1	2	Human	6.7	pEC50	None	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	17358052
	1599	6931	0	None	-1	2	Human	6.7	pEC50	None	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	17358052
	CHEMBL424938	6931	0	None	-1	2	Human	6.7	pEC50	None	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	238	2	1	4	1.8	Cc1scc(c1)C1(C)OC(=CC1=O)C(=O)O	17358052
	53232	195404	95	None	1	10	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	None
	CHEMBL503	195404	95	None	1	10	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	None

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1595	7047	49	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmc.2015.02.018
	51576	7047	49	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmc.2015.02.018
	CHEMBL278488	7047	49	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAAgonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA	ChEMBL	218	2	1	3	1.5	OC(=O)C1=CC(=O)C(O1)(C)c1ccccc1	10.1016/j.bmc.2015.02.018
	135899171	22942	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of radioligand from human GPR109BDisplacement of radioligand from human GPR109B	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12	10.1016/j.bmcl.2010.07.108
	CHEMBL1224070	22942	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of radioligand from human GPR109BDisplacement of radioligand from human GPR109B	ChEMBL	331	6	1	5	2.8	O=c1[nH]c(OCCCOc2ccccc2Cl)nc2ncccc12	10.1016/j.bmcl.2010.07.108

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Main reference

Ligand source activities (1 row/activity)