Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 148258520 | 169740 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 450 | 5 | 2 | 5 | 3.8 | N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2ccc[nH]c2=O)c1 | nan | ||
| CHEMBL4437187 | 169740 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 450 | 5 | 2 | 5 | 3.8 | N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2ccc[nH]c2=O)c1 | nan | ||
| 151597098 | 170543 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 476 | 5 | 1 | 6 | 3.9 | Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(C(=O)c3cc(F)ccc3F)CC2)c1=O | nan | ||
| CHEMBL4448613 | 170543 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 476 | 5 | 1 | 6 | 3.9 | Cn1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(C(=O)c3cc(F)ccc3F)CC2)c1=O | nan | ||
| 151676814 | 171220 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 529 | 7 | 1 | 7 | 3.9 | COc1ncc(F)cc1C(=O)Nc1cnc(C(=O)N(C)C)cc1N1CCC(Oc2ccc(F)cc2F)CC1 | nan | ||
| CHEMBL4458016 | 171220 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 529 | 7 | 1 | 7 | 3.9 | COc1ncc(F)cc1C(=O)Nc1cnc(C(=O)N(C)C)cc1N1CCC(Oc2ccc(F)cc2F)CC1 | nan | ||
| 152710332 | 171292 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 541 | 6 | 1 | 5 | 5.9 | COc1cc(Br)ccc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 | nan | ||
| CHEMBL4459171 | 171292 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 541 | 6 | 1 | 5 | 5.9 | COc1cc(Br)ccc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 | nan | ||
| 149729892 | 171434 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 452 | 6 | 1 | 7 | 3.4 | COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(Cc2ccccc2C#N)CC1 | nan | ||
| CHEMBL4461245 | 171434 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 452 | 6 | 1 | 7 | 3.4 | COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(Cc2ccccc2C#N)CC1 | nan | ||
| 149672766 | 171466 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 439 | 5 | 1 | 5 | 4.0 | Cn1cccc(C(=O)Nc2ccccc2N2CCC(Oc3ccc(F)cc3F)CC2)c1=O | nan | ||
| CHEMBL4461704 | 171466 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 439 | 5 | 1 | 5 | 4.0 | Cn1cccc(C(=O)Nc2ccccc2N2CCC(Oc3ccc(F)cc3F)CC2)c1=O | nan | ||
| 150577755 | 171557 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 452 | 5 | 1 | 6 | 4.7 | Cc1onc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c1C | nan | ||
| CHEMBL4463278 | 171557 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 452 | 5 | 1 | 6 | 4.7 | Cc1onc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c1C | nan | ||
| 152117365 | 171580 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 454 | 5 | 1 | 6 | 4.9 | Cc1nc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)cs1 | nan | ||
| CHEMBL4463584 | 171580 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 454 | 5 | 1 | 6 | 4.9 | Cc1nc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)cs1 | nan | ||
| 155531704 | 171787 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 399 | 5 | 1 | 6 | 3.6 | N#Cc1cnc(N2CCC(Oc3ccccc3)CC2)c(NC(=O)c2ccccn2)c1 | nan | ||
| CHEMBL4466414 | 171787 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 399 | 5 | 1 | 6 | 3.6 | N#Cc1cnc(N2CCC(Oc3ccccc3)CC2)c(NC(=O)c2ccccn2)c1 | nan | ||
| 151827186 | 171969 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 470 | 7 | 2 | 7 | 3.6 | COc1ncccc1C(=O)Nc1cc(CO)cnc1N1CCC(Oc2ccc(F)cc2F)CC1 | nan | ||
| CHEMBL4469138 | 171969 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 470 | 7 | 2 | 7 | 3.6 | COc1ncccc1C(=O)Nc1cc(CO)cnc1N1CCC(Oc2ccc(F)cc2F)CC1 | nan | ||
| 152247712 | 172167 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 550 | 9 | 1 | 9 | 3.7 | COc1ccc(OC2CCN(c3ccc(S(C)(=O)=O)cc3NC(=O)c3cn(CF)nc3OC)CC2)c(F)c1 | nan | ||
| CHEMBL4472092 | 172167 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 550 | 9 | 1 | 9 | 3.7 | COc1ccc(OC2CCN(c3ccc(S(C)(=O)=O)cc3NC(=O)c3cn(CF)nc3OC)CC2)c(F)c1 | nan | ||
| 135349192 | 172609 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 464 | 6 | 1 | 6 | 4.5 | COc1cnccc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 | nan | ||
| CHEMBL4483436 | 172609 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 464 | 6 | 1 | 6 | 4.5 | COc1cnccc1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 | nan | ||
| 151207233 | 173096 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 452 | 5 | 1 | 5 | 4.7 | N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2ncccc2F)c1 | nan | ||
| CHEMBL4517992 | 173096 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 452 | 5 | 1 | 5 | 4.7 | N#Cc1ccc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2ncccc2F)c1 | nan | ||
| 150707294 | 174014 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 589 | 7 | 1 | 9 | 2.4 | Cn1cccc(C(=O)Nc2cc(S(=O)(=O)N3CCOCC3)cnc2N2CCC(Oc3ccc(F)cc3F)CC2)c1=O | nan | ||
| CHEMBL4540377 | 174014 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 589 | 7 | 1 | 9 | 2.4 | Cn1cccc(C(=O)Nc2cc(S(=O)(=O)N3CCOCC3)cnc2N2CCC(Oc3ccc(F)cc3F)CC2)c1=O | nan | ||
| 153518593 | 174951 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 511 | 8 | 2 | 7 | 3.8 | CCNC(=O)c1cc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cccnc2OC)cn1 | nan | ||
| CHEMBL4562967 | 174951 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 511 | 8 | 2 | 7 | 3.8 | CCNC(=O)c1cc(N2CCC(Oc3ccc(F)cc3F)CC2)c(NC(=O)c2cccnc2OC)cn1 | nan | ||
| 152221334 | 174972 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 511 | 8 | 2 | 7 | 3.7 | COc1ncccc1C(=O)Nc1cc(CNC(C)=O)cnc1N1CCC(Oc2ccc(F)cc2F)CC1 | nan | ||
| CHEMBL4563440 | 174972 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 511 | 8 | 2 | 7 | 3.7 | COc1ncccc1C(=O)Nc1cc(CNC(C)=O)cnc1N1CCC(Oc2ccc(F)cc2F)CC1 | nan | ||
| 135349293 | 175837 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 457 | 6 | 1 | 7 | 3.7 | COc1nn(C)cc1C(=O)Nc1cc(C)cnc1N1CCC(Oc2ccc(F)cc2F)CC1 | nan | ||
| CHEMBL4582790 | 175837 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 457 | 6 | 1 | 7 | 3.7 | COc1nn(C)cc1C(=O)Nc1cc(C)cnc1N1CCC(Oc2ccc(F)cc2F)CC1 | nan | ||
| 135349224 | 175978 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 464 | 6 | 1 | 6 | 4.5 | COc1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)n1 | nan | ||
| CHEMBL4586098 | 175978 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 464 | 6 | 1 | 6 | 4.5 | COc1cccc(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)n1 | nan | ||
| 151157020 | 170085 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 479 | 7 | 1 | 9 | 2.4 | COc1cc(F)cc(CN2CCN(c3ncc(C#N)cc3NC(=O)c3cn(C)nc3OC)CC2)c1 | nan | ||
| CHEMBL4442075 | 170085 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 479 | 7 | 1 | 9 | 2.4 | COc1cc(F)cc(CN2CCN(c3ncc(C#N)cc3NC(=O)c3cn(C)nc3OC)CC2)c1 | nan | ||
| 150728057 | 170247 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 459 | 6 | 1 | 6 | 4.2 | COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(C(C)c2ccc(F)cc2)CC1 | nan | ||
| CHEMBL4444226 | 170247 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 459 | 6 | 1 | 6 | 4.2 | COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(C(C)c2ccc(F)cc2)CC1 | nan | ||
| 150140683 | 170789 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 434 | 6 | 1 | 8 | 3.0 | COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(Cc2cscn2)CC1 | nan | ||
| CHEMBL4451762 | 170789 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 434 | 6 | 1 | 8 | 3.0 | COc1ncccc1C(=O)Nc1cc(C#N)ccc1N1CCN(Cc2cscn2)CC1 | nan | ||
| 151151185 | 172109 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 493 | 7 | 1 | 6 | 5.2 | COc1ccc(OC)c(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c1 | nan | ||
| CHEMBL4471381 | 172109 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 493 | 7 | 1 | 6 | 5.2 | COc1ccc(OC)c(C(=O)Nc2cc(C#N)ccc2N2CCC(Oc3ccc(F)cc3F)CC2)c1 | nan | ||
| 149264745 | 173824 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 458 | 7 | 1 | 8 | 2.9 | COc1ccc(CN2CCN(c3ccc(C#N)cc3NC(=O)c3cccnc3OC)CC2)nc1 | nan | ||
| CHEMBL4536167 | 173824 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 458 | 7 | 1 | 8 | 2.9 | COc1ccc(CN2CCN(c3ccc(C#N)cc3NC(=O)c3cccnc3OC)CC2)nc1 | nan | ||
| 151831310 | 172331 | None | 0 | Human | Functional | pEC50 | = | 5 | 5.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 493 | 7 | 1 | 6 | 5.2 | COc1cccc(OC)c1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 | nan | ||
| CHEMBL4474095 | 172331 | None | 0 | Human | Functional | pEC50 | = | 5 | 5.0 | - | 1 | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assayModulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay |
ChEMBL | 493 | 7 | 1 | 6 | 5.2 | COc1cccc(OC)c1C(=O)Nc1cc(C#N)ccc1N1CCC(Oc2ccc(F)cc2F)CC1 | nan | ||
| CHEMBL5081373 | 217233 | None | 0 | Human | Functional | pEC50 | = | 4 | 4.0 | - | 1 | Inverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assayInverse agonist activity at human GPR6 expressed in CHO-K1 cells assessed as modulation of cAMP level incubated for 20 hrs by TR-FRET assay |
ChEMBL | None | None | None | CC(C)Nc1nc2c(nc1N1CCC(Oc3ccc(F)cc3F)CC1)C=CNC2 | 10.1021/acs.jmedchem.0c02081 | ||||
| 118310228 | 181595 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Modulation of GPR6 (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity by HTRF assayModulation of GPR6 (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity by HTRF assay |
ChEMBL | 440 | 5 | 1 | 7 | 3.1 | Cc1cc2nc(N3CCN(Cc4ccc(F)cc4F)CC3)c(N[C@@H]3CCOC3)nc2cn1 | nan | ||
Showing 1 to 50 of 2,804 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 11601669 | 90652 | None | 24 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 2 | Binding affinity to human GPR6 expressed in HEK293 cells assessed as reduction in cAMP level incubated for 1 hr by HTRF assayBinding affinity to human GPR6 expressed in HEK293 cells assessed as reduction in cAMP level incubated for 1 hr by HTRF assay |
ChEMBL | 286 | 4 | 2 | 2 | 5.1 | C=C(C)[C@@H]1CCC(C)=C[C@H]1c1c(O)cc(CCC)cc1O | 10.1021/acs.jnatprod.0c00965 | ||
| CHEMBL2387742 | 90652 | None | 24 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 2 | Binding affinity to human GPR6 expressed in HEK293 cells assessed as reduction in cAMP level incubated for 1 hr by HTRF assayBinding affinity to human GPR6 expressed in HEK293 cells assessed as reduction in cAMP level incubated for 1 hr by HTRF assay |
ChEMBL | 286 | 4 | 2 | 2 | 5.1 | C=C(C)[C@@H]1CCC(C)=C[C@H]1c1c(O)cc(CCC)cc1O | 10.1021/acs.jnatprod.0c00965 | ||
| 172452129 | 195773 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | 7 | 2 | Competitive total binding affinity to full-length wild-type human brain GPR6 expressed in HEK293A cells using furimazine as substrate at 1 uM measured for 3 hrs in presence of CVN424 by NanoBRET assayCompetitive total binding affinity to full-length wild-type human brain GPR6 expressed in HEK293A cells using furimazine as substrate at 1 uM measured for 3 hrs in presence of CVN424 by NanoBRET assay |
ChEMBL | 920 | 19 | 2 | 12 | 9.6 | CC(C)Oc1cc(Cl)ccc1CNc1cc(-c2ccccc2OCCCCCCNC(=O)c2ccc(-c3c4ccc(N(C)C)cc4[o+]c4cc(N(C)C)ccc34)c(C(=O)[O-])c2)nc2ncnn12 | 10.1021/acs.jmedchem.3c01707 | ||
| CHEMBL5410506 | 195773 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | 7 | 2 | Competitive total binding affinity to full-length wild-type human brain GPR6 expressed in HEK293A cells using furimazine as substrate at 1 uM measured for 3 hrs in presence of CVN424 by NanoBRET assayCompetitive total binding affinity to full-length wild-type human brain GPR6 expressed in HEK293A cells using furimazine as substrate at 1 uM measured for 3 hrs in presence of CVN424 by NanoBRET assay |
ChEMBL | 920 | 19 | 2 | 12 | 9.6 | CC(C)Oc1cc(Cl)ccc1CNc1cc(-c2ccccc2OCCCCCCNC(=O)c2ccc(-c3c4ccc(N(C)C)cc4[o+]c4cc(N(C)C)ccc34)c(C(=O)[O-])c2)nc2ncnn12 | 10.1021/acs.jmedchem.3c01707 | ||
| 172452129 | 195773 | None | 0 | Human | Binding | pKd | = | 7.2 | 7.2 | 7 | 2 | Specific binding affinity to full-length wild-type human brain GPR6 expressed in HEK293A cells using furimazine as substrate measured for 3 hrs by NanoBRET assaySpecific binding affinity to full-length wild-type human brain GPR6 expressed in HEK293A cells using furimazine as substrate measured for 3 hrs by NanoBRET assay |
ChEMBL | 920 | 19 | 2 | 12 | 9.6 | CC(C)Oc1cc(Cl)ccc1CNc1cc(-c2ccccc2OCCCCCCNC(=O)c2ccc(-c3c4ccc(N(C)C)cc4[o+]c4cc(N(C)C)ccc34)c(C(=O)[O-])c2)nc2ncnn12 | 10.1021/acs.jmedchem.3c01707 | ||
| CHEMBL5410506 | 195773 | None | 0 | Human | Binding | pKd | = | 7.2 | 7.2 | 7 | 2 | Specific binding affinity to full-length wild-type human brain GPR6 expressed in HEK293A cells using furimazine as substrate measured for 3 hrs by NanoBRET assaySpecific binding affinity to full-length wild-type human brain GPR6 expressed in HEK293A cells using furimazine as substrate measured for 3 hrs by NanoBRET assay |
ChEMBL | 920 | 19 | 2 | 12 | 9.6 | CC(C)Oc1cc(Cl)ccc1CNc1cc(-c2ccccc2OCCCCCCNC(=O)c2ccc(-c3c4ccc(N(C)C)cc4[o+]c4cc(N(C)C)ccc34)c(C(=O)[O-])c2)nc2ncnn12 | 10.1021/acs.jmedchem.3c01707 | ||
| 172452129 | 195773 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 7 | 2 | Competitive total binding affinity to full-length wild-type human brain GPR6 expressed in HEK293A cells using furimazine as substrate at 1 uM measured for 3 hrs in presence of CVN424 by NanoBRET assayCompetitive total binding affinity to full-length wild-type human brain GPR6 expressed in HEK293A cells using furimazine as substrate at 1 uM measured for 3 hrs in presence of CVN424 by NanoBRET assay |
ChEMBL | 920 | 19 | 2 | 12 | 9.6 | CC(C)Oc1cc(Cl)ccc1CNc1cc(-c2ccccc2OCCCCCCNC(=O)c2ccc(-c3c4ccc(N(C)C)cc4[o+]c4cc(N(C)C)ccc34)c(C(=O)[O-])c2)nc2ncnn12 | 10.1021/acs.jmedchem.3c01707 | ||
| CHEMBL5410506 | 195773 | None | 0 | Human | Binding | pKi | = | 7.9 | 7.9 | 7 | 2 | Competitive total binding affinity to full-length wild-type human brain GPR6 expressed in HEK293A cells using furimazine as substrate at 1 uM measured for 3 hrs in presence of CVN424 by NanoBRET assayCompetitive total binding affinity to full-length wild-type human brain GPR6 expressed in HEK293A cells using furimazine as substrate at 1 uM measured for 3 hrs in presence of CVN424 by NanoBRET assay |
ChEMBL | 920 | 19 | 2 | 12 | 9.6 | CC(C)Oc1cc(Cl)ccc1CNc1cc(-c2ccccc2OCCCCCCNC(=O)c2ccc(-c3c4ccc(N(C)C)cc4[o+]c4cc(N(C)C)ccc34)c(C(=O)[O-])c2)nc2ncnn12 | 10.1021/acs.jmedchem.3c01707 | ||
| CHEMBL5093828 | 217936 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | Displacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assayDisplacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assay |
ChEMBL | None | None | None | CC(=O)N1C=Cc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(NC(C)C)nc2C1 | 10.1021/acs.jmedchem.0c02081 | ||||
| 11514 | 1223 | None | 16 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Binding affinity to GPR6 (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting based competition binding assayBinding affinity to GPR6 (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting based competition binding assay |
ChEMBL | 473 | 5 | 1 | 7 | 2.9 | Fc1ccc(c(c1)F)OC1CCN(CC1)c1nc2CCN(Cc2nc1N[C@H]1COCC1)C(=O)C | nan | ||
| 137359492 | 1223 | None | 16 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Binding affinity to GPR6 (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting based competition binding assayBinding affinity to GPR6 (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting based competition binding assay |
ChEMBL | 473 | 5 | 1 | 7 | 2.9 | Fc1ccc(c(c1)F)OC1CCN(CC1)c1nc2CCN(Cc2nc1N[C@H]1COCC1)C(=O)C | nan | ||
| 137359492.0 | 1223 | None | 16 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Binding affinity to GPR6 (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting based competition binding assayBinding affinity to GPR6 (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting based competition binding assay |
ChEMBL | 473 | 5 | 1 | 7 | 2.9 | Fc1ccc(c(c1)F)OC1CCN(CC1)c1nc2CCN(Cc2nc1N[C@H]1COCC1)C(=O)C | nan | ||
| CHEMBL4778540 | 1223 | None | 16 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Binding affinity to GPR6 (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting based competition binding assayBinding affinity to GPR6 (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting based competition binding assay |
ChEMBL | 473 | 5 | 1 | 7 | 2.9 | Fc1ccc(c(c1)F)OC1CCN(CC1)c1nc2CCN(Cc2nc1N[C@H]1COCC1)C(=O)C | nan | ||
| CHEMBL4802203 | 1223 | None | 16 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Binding affinity to GPR6 (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting based competition binding assayBinding affinity to GPR6 (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting based competition binding assay |
ChEMBL | 473 | 5 | 1 | 7 | 2.9 | Fc1ccc(c(c1)F)OC1CCN(CC1)c1nc2CCN(Cc2nc1N[C@H]1COCC1)C(=O)C | nan | ||
| DB18958 | 1223 | None | 16 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Binding affinity to GPR6 (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting based competition binding assayBinding affinity to GPR6 (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting based competition binding assay |
ChEMBL | 473 | 5 | 1 | 7 | 2.9 | Fc1ccc(c(c1)F)OC1CCN(CC1)c1nc2CCN(Cc2nc1N[C@H]1COCC1)C(=O)C | nan | ||
| 118159164 | 151623 | None | 8 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | Binding affinity to GPR6 (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting based competition binding assayBinding affinity to GPR6 (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting based competition binding assay |
ChEMBL | 473 | 5 | 1 | 7 | 2.9 | CC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(N[C@H]3CCOC3)nc2C1 | nan | ||
| CHEMBL3962956 | 151623 | None | 8 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | Binding affinity to GPR6 (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting based competition binding assayBinding affinity to GPR6 (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting based competition binding assay |
ChEMBL | 473 | 5 | 1 | 7 | 2.9 | CC(=O)N1CCc2nc(N3CCC(Oc4ccc(F)cc4F)CC3)c(N[C@H]3CCOC3)nc2C1 | nan | ||
| 118308612 | 176795 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | Displacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assayDisplacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assay |
ChEMBL | 396 | 5 | 1 | 6 | 3.2 | Fc1ccc(CN2CCN(c3nc4cnccc4nc3NC3CC3)CC2)c(F)c1 | 10.1021/acs.jmedchem.0c02081 | ||
| CHEMBL4474256 | 176795 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | Displacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assayDisplacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assay |
ChEMBL | 396 | 5 | 1 | 6 | 3.2 | Fc1ccc(CN2CCN(c3nc4cnccc4nc3NC3CC3)CC2)c(F)c1 | 10.1021/acs.jmedchem.0c02081 | ||
| CHEMBL4598390 | 176795 | None | 0 | Human | Binding | pKi | = | 8.2 | 8.2 | - | 1 | Displacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assayDisplacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assay |
ChEMBL | 396 | 5 | 1 | 6 | 3.2 | Fc1ccc(CN2CCN(c3nc4cnccc4nc3NC3CC3)CC2)c(F)c1 | 10.1021/acs.jmedchem.0c02081 | ||
| 11514 | 1223 | None | 16 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | Displacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assayDisplacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assay |
ChEMBL | 473 | 5 | 1 | 7 | 2.9 | Fc1ccc(c(c1)F)OC1CCN(CC1)c1nc2CCN(Cc2nc1N[C@H]1COCC1)C(=O)C | 10.1021/acs.jmedchem.0c02081 | ||
| 137359492 | 1223 | None | 16 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | Displacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assayDisplacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assay |
ChEMBL | 473 | 5 | 1 | 7 | 2.9 | Fc1ccc(c(c1)F)OC1CCN(CC1)c1nc2CCN(Cc2nc1N[C@H]1COCC1)C(=O)C | 10.1021/acs.jmedchem.0c02081 | ||
| 137359492.0 | 1223 | None | 16 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | Displacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assayDisplacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assay |
ChEMBL | 473 | 5 | 1 | 7 | 2.9 | Fc1ccc(c(c1)F)OC1CCN(CC1)c1nc2CCN(Cc2nc1N[C@H]1COCC1)C(=O)C | 10.1021/acs.jmedchem.0c02081 | ||
| CHEMBL4778540 | 1223 | None | 16 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | Displacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assayDisplacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assay |
ChEMBL | 473 | 5 | 1 | 7 | 2.9 | Fc1ccc(c(c1)F)OC1CCN(CC1)c1nc2CCN(Cc2nc1N[C@H]1COCC1)C(=O)C | 10.1021/acs.jmedchem.0c02081 | ||
| CHEMBL4802203 | 1223 | None | 16 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | Displacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assayDisplacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assay |
ChEMBL | 473 | 5 | 1 | 7 | 2.9 | Fc1ccc(c(c1)F)OC1CCN(CC1)c1nc2CCN(Cc2nc1N[C@H]1COCC1)C(=O)C | 10.1021/acs.jmedchem.0c02081 | ||
| DB18958 | 1223 | None | 16 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | Displacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assayDisplacement of 3H-RL338 from human GPR6 expressed in T-REx-CHO-GPR6 cells assessed as inhibition constant by competition binding assay |
ChEMBL | 473 | 5 | 1 | 7 | 2.9 | Fc1ccc(c(c1)F)OC1CCN(CC1)c1nc2CCN(Cc2nc1N[C@H]1COCC1)C(=O)C | 10.1021/acs.jmedchem.0c02081 | ||
| 11514 | 1223 | None | 16 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 473 | 5 | 1 | 7 | 2.9 | Fc1ccc(c(c1)F)OC1CCN(CC1)c1nc2CCN(Cc2nc1N[C@H]1COCC1)C(=O)C | 33861086 | ||
| 137359492 | 1223 | None | 16 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 473 | 5 | 1 | 7 | 2.9 | Fc1ccc(c(c1)F)OC1CCN(CC1)c1nc2CCN(Cc2nc1N[C@H]1COCC1)C(=O)C | 33861086 | ||
| 137359492.0 | 1223 | None | 16 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 473 | 5 | 1 | 7 | 2.9 | Fc1ccc(c(c1)F)OC1CCN(CC1)c1nc2CCN(Cc2nc1N[C@H]1COCC1)C(=O)C | 33861086 | ||
| CHEMBL4778540 | 1223 | None | 16 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 473 | 5 | 1 | 7 | 2.9 | Fc1ccc(c(c1)F)OC1CCN(CC1)c1nc2CCN(Cc2nc1N[C@H]1COCC1)C(=O)C | 33861086 | ||
| CHEMBL4802203 | 1223 | None | 16 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 473 | 5 | 1 | 7 | 2.9 | Fc1ccc(c(c1)F)OC1CCN(CC1)c1nc2CCN(Cc2nc1N[C@H]1COCC1)C(=O)C | 33861086 | ||
| DB18958 | 1223 | None | 16 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 473 | 5 | 1 | 7 | 2.9 | Fc1ccc(c(c1)F)OC1CCN(CC1)c1nc2CCN(Cc2nc1N[C@H]1COCC1)C(=O)C | 33861086 | ||
Showing 1 to 32 of 32 entries