Ligand source activities (1 row/activity)





Ligands Receptor Assay information Chemical information
Sel. page Common
name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Potency)
# tested GPCRs
(Potency)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
CHEMBL342252 218452 0 None 2 4 Rat 11.0 pEC50 = 11 Functional
Agonist activity at rat NTS1 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS1 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm5003843
1574 9585 20 None 26 6 Rat 10.4 pEC50 = 10.4 Functional
Agonist activity at rat NTS1 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS1 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL None None None None 10.1021/jm5003843
1579 9585 20 None 26 6 Rat 10.4 pEC50 = 10.4 Functional
Agonist activity at rat NTS1 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS1 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL None None None None 10.1021/jm5003843
25077406 9585 20 None 26 6 Rat 10.4 pEC50 = 10.4 Functional
Agonist activity at rat NTS1 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS1 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL None None None None 10.1021/jm5003843
3830 9585 20 None 26 6 Rat 10.4 pEC50 = 10.4 Functional
Agonist activity at rat NTS1 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS1 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL None None None None 10.1021/jm5003843
CHEMBL407196 9585 20 None 26 6 Rat 10.4 pEC50 = 10.4 Functional
Agonist activity at rat NTS1 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assayAgonist activity at rat NTS1 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
ChEMBL None None None None 10.1021/jm5003843
1569 8907 32 None 2 3 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL None None None None 10.1016/j.bmcl.2014.06.033
5311318 8907 32 None 2 3 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL None None None None 10.1016/j.bmcl.2014.06.033
CHEMBL415788 8907 32 None 2 3 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL None None None None 10.1016/j.bmcl.2014.06.033
1569 8907 32 None 2 3 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescence assayAgonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescence assay
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
5311318 8907 32 None 2 3 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescence assayAgonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescence assay
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
CHEMBL415788 8907 32 None 2 3 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescence assayAgonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescence assay
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
1574 9585 20 None -26 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL None None None None 10.1016/j.bmcl.2009.01.024
1579 9585 20 None -26 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL None None None None 10.1016/j.bmcl.2009.01.024
25077406 9585 20 None -26 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL None None None None 10.1016/j.bmcl.2009.01.024
3830 9585 20 None -26 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL None None None None 10.1016/j.bmcl.2009.01.024
CHEMBL407196 9585 20 None -26 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL None None None None 10.1016/j.bmcl.2009.01.024
155569717 183018 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescence assayAgonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescence assay
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4537266 183018 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescence assayAgonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescence assay
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4594723 183018 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescence assayAgonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescence assay
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
1569 8907 32 None 2 3 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00175
5311318 8907 32 None 2 3 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00175
CHEMBL415788 8907 32 None 2 3 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00175
155569737 183414 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescence assayAgonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescence assay
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4457798 183414 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescence assayAgonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescence assay
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4597941 183414 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescence assayAgonist activity at human neurotensin receptor 1 expressed in CHO cells assessed as increase in intracellular calcium by Fluo-4 dye based fluorescence assay
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
1569 8907 32 None 2 3 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00175
5311318 8907 32 None 2 3 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00175
CHEMBL415788 8907 32 None 2 3 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00175
1569 8907 32 None 2 3 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00175
5311318 8907 32 None 2 3 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00175
CHEMBL415788 8907 32 None 2 3 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00175
1569 8907 32 None 2 3 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00175
5311318 8907 32 None 2 3 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00175
CHEMBL415788 8907 32 None 2 3 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b00175
CHEMBL504768 220963 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)N=[N+]=[N-])C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
CHEMBL468951 220805 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
CHEMBL342252 218452 0 None -2 4 Human 9.0 pEC50 = 9 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
127030965 145981 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysisAgonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
155559776 145981 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysisAgonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL3787709 145981 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysisAgonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4564746 145981 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysisAgonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
118610427 182215 25 None - 1 Human 8.9 pEC50 = 8.9 Functional
Positive allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as effect on NT (8 to 13) peptide-mediated calcium flux by measuring neurotensin EC50 at 0.0088 to 2.15 uM (Rvb = 0.035 nM)Positive allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as effect on NT (8 to 13) peptide-mediated calcium flux by measuring neurotensin EC50 at 0.0088 to 2.15 uM (Rvb = 0.035 nM)
ChEMBL 450 7 1 6 4.4 COc1ccccc1C1CCN(c2nc(C3(F)CC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4576388 182215 25 None - 1 Human 8.9 pEC50 = 8.9 Functional
Positive allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as effect on NT (8 to 13) peptide-mediated calcium flux by measuring neurotensin EC50 at 0.0088 to 2.15 uM (Rvb = 0.035 nM)Positive allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as effect on NT (8 to 13) peptide-mediated calcium flux by measuring neurotensin EC50 at 0.0088 to 2.15 uM (Rvb = 0.035 nM)
ChEMBL 450 7 1 6 4.4 COc1ccccc1C1CCN(c2nc(C3(F)CC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
1569 8907 32 None 2 3 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysisAgonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysis
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
5311318 8907 32 None 2 3 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysisAgonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysis
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
CHEMBL415788 8907 32 None 2 3 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysisAgonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysis
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
1569 8907 32 None 2 3 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
5311318 8907 32 None 2 3 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
CHEMBL415788 8907 32 None 2 3 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
1569 8907 32 None 2 3 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
5311318 8907 32 None 2 3 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
CHEMBL415788 8907 32 None 2 3 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
44123840 179515 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant NTS1 receptor expressed in HEK293 cells assessed as stimulation of Ca2+ mobilizationAgonist activity at human recombinant NTS1 receptor expressed in HEK293 cells assessed as stimulation of Ca2+ mobilization
ChEMBL 1173 48 15 16 0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCNCCCNCCCNCCCCNCCCN)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801481y
CHEMBL450740 179515 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant NTS1 receptor expressed in HEK293 cells assessed as stimulation of Ca2+ mobilizationAgonist activity at human recombinant NTS1 receptor expressed in HEK293 cells assessed as stimulation of Ca2+ mobilization
ChEMBL 1173 48 15 16 0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCNCCCNCCCNCCCCNCCCN)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801481y
127032102 145976 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL 931 28 14 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786852 145976 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL 931 28 14 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787704 145976 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL 931 28 14 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
1574 9585 20 None -26 6 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human NTS1 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS1 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity
ChEMBL None None None None 10.1021/jm200006c
1579 9585 20 None -26 6 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human NTS1 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS1 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity
ChEMBL None None None None 10.1021/jm200006c
25077406 9585 20 None -26 6 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human NTS1 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS1 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity
ChEMBL None None None None 10.1021/jm200006c
3830 9585 20 None -26 6 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human NTS1 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS1 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity
ChEMBL None None None None 10.1021/jm200006c
CHEMBL407196 9585 20 None -26 6 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human NTS1 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activityAgonist activity at human NTS1 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity
ChEMBL None None None None 10.1021/jm200006c
127032102 145976 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL 931 28 14 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786852 145976 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL 931 28 14 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787704 145976 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL 931 28 14 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
44572616 195561 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL 801 24 12 9 -0.0 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
CHEMBL505695 195561 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL 801 24 12 9 -0.0 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
CHEMBL344337 218484 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
1574 9585 20 None -26 6 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL None None None None 10.1021/jm801072v
1579 9585 20 None -26 6 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL None None None None 10.1021/jm801072v
25077406 9585 20 None -26 6 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL None None None None 10.1021/jm801072v
3830 9585 20 None -26 6 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL None None None None 10.1021/jm801072v
CHEMBL407196 9585 20 None -26 6 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL None None None None 10.1021/jm801072v
127032412 145978 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3785364 145978 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3786291 145978 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3787706 145978 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL4579623 145978 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
3631325 61592 19 None - 1 Human 5.0 pEC50 = 5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 275 5 0 5 2.4 COc1ccc(C(C[N+](=O)[O-])n2nc(C)cc2C)cc1 nan
CHEMBL1612634 61592 19 None - 1 Human 5.0 pEC50 = 5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 275 5 0 5 2.4 COc1ccc(C(C[N+](=O)[O-])n2nc(C)cc2C)cc1 nan
3357104 53734 6 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 497 7 1 7 2.9 CCc1nc2ccccc2c(C(=O)OCC(=O)Nc2cccc(S(=O)(=O)N3CCOCC3)c2)c1C nan
CHEMBL1541329 53734 6 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 497 7 1 7 2.9 CCc1nc2ccccc2c(C(=O)OCC(=O)Nc2cccc(S(=O)(=O)N3CCOCC3)c2)c1C nan
2172285 41377 10 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 385 3 1 4 3.8 Cc1cc(C)cc(N2C(=O)NC(=O)/C(=C\c3cccn3-c3ccccc3)C2=O)c1 nan
CHEMBL1429636 41377 10 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 385 3 1 4 3.8 Cc1cc(C)cc(N2C(=O)NC(=O)/C(=C\c3cccn3-c3ccccc3)C2=O)c1 nan
1804911 36934 8 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 419 3 1 4 4.4 Cc1cc(C)cc(N2C(=O)NC(=O)/C(=C/c3cccn3-c3ccc(Cl)cc3)C2=O)c1 nan
CHEMBL1390127 36934 8 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 419 3 1 4 4.4 Cc1cc(C)cc(N2C(=O)NC(=O)/C(=C/c3cccn3-c3ccc(Cl)cc3)C2=O)c1 nan
145974670 171417 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 799 13 9 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4216311 171417 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 799 13 9 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
1519056 78544 6 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 374 3 0 6 3.2 COC(=O)c1cc(=O)n(-c2ccc(F)cc2)/c(=N/c2ccc(F)cc2)s1 nan
CHEMBL1966872 78544 6 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 374 3 0 6 3.2 COC(=O)c1cc(=O)n(-c2ccc(F)cc2)/c(=N/c2ccc(F)cc2)s1 nan
1899419 57015 10 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 314 3 2 5 2.2 O=C1NC(=O)C(=Cc2ccc(Sc3ccccc3)o2)C(=O)N1 nan
CHEMBL1571258 57015 10 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 314 3 2 5 2.2 O=C1NC(=O)C(=Cc2ccc(Sc3ccccc3)o2)C(=O)N1 nan
16319272 52577 3 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 245 3 0 2 3.3 O=C(/C=C/c1cccnc1)c1ccc(F)c(F)c1 nan
CHEMBL1530988 52577 3 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 245 3 0 2 3.3 O=C(/C=C/c1cccnc1)c1ccc(F)c(F)c1 nan
145967420 171059 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 997 16 8 13 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCN(S(=O)(=O)c2ccccc2[N+](=O)[O-])CCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4211866 171059 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 997 16 8 13 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCN(S(=O)(=O)c2ccccc2[N+](=O)[O-])CCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
15945158 41787 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 386 5 0 4 5.7 O=C(/C=C\c1ccccc1OC(=O)c1ccccc1F)c1cc2ccccc2o1 nan
CHEMBL1433015 41787 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 386 5 0 4 5.7 O=C(/C=C\c1ccccc1OC(=O)c1ccccc1F)c1cc2ccccc2o1 nan
7341556 30079 8 None -1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 361 2 1 4 2.9 CN1C(=O)/C(=C/c2cccn2-c2ccc3ccccc3c2)C(=O)NC1=S nan
CHEMBL1332241 30079 8 None -1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 361 2 1 4 2.9 CN1C(=O)/C(=C/c2cccn2-c2ccc3ccccc3c2)C(=O)NC1=S nan
695637 61497 10 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 329 3 1 5 3.4 COc1cc(/C=C2\C(=O)ON=C2c2ccc(Cl)cc2)ccc1O nan
CHEMBL1611796 61497 10 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 329 3 1 5 3.4 COc1cc(/C=C2\C(=O)ON=C2c2ccc(Cl)cc2)ccc1O nan
44157044 197794 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL 546 8 2 6 5.9 CC(C)C[C@H](NC(=O)c1cc(-c2ccccc2OC(F)(F)F)n(-c2ccnc3cc(Cl)ccc23)n1)C(=O)O 10.1016/j.bmcl.2009.01.024
CHEMBL518675 197794 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL 546 8 2 6 5.9 CC(C)C[C@H](NC(=O)c1cc(-c2ccccc2OC(F)(F)F)n(-c2ccnc3cc(Cl)ccc23)n1)C(=O)O 10.1016/j.bmcl.2009.01.024
182785 194219 2 None 1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 327 4 2 3 6.0 CC(C)Nc1ccc(Nc2ccnc3cc4ccccc4cc23)cc1 nan
CHEMBL493863 194219 2 None 1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 327 4 2 3 6.0 CC(C)Nc1ccc(Nc2ccnc3cc4ccccc4cc23)cc1 nan
135400412 74066 6 None -1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 379 5 2 2 4.6 O=C(N/N=C/c1c[nH]c2ccccc12)C1CC1(c1ccccc1)c1ccccc1 nan
CHEMBL1882689 74066 6 None -1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 379 5 2 2 4.6 O=C(N/N=C/c1c[nH]c2ccccc12)C1CC1(c1ccccc1)c1ccccc1 nan
5418979 31603 10 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 330 3 1 4 2.5 O=C1NC(=O)N(Cc2ccc(F)cc2)C(=O)/C1=C/c1cccs1 nan
CHEMBL1344927 31603 10 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 330 3 1 4 2.5 O=C1NC(=O)N(Cc2ccc(F)cc2)C(=O)/C1=C/c1cccs1 nan
6526694 34378 3 None -23 5 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 364 4 1 3 5.7 O=C(/C(=C/c1ccc(Cl)cc1)c1nc2ccccc2[nH]1)c1cccs1 nan
CHEMBL1369594 34378 3 None -23 5 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 364 4 1 3 5.7 O=C(/C(=C/c1ccc(Cl)cc1)c1nc2ccccc2[nH]1)c1cccs1 nan
3124420 62441 4 None -1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 384 4 0 0 7.0 c1ccc(-c2cc(-c3ccccc3)[n+](-c3ccccc3)c(-c3ccccc3)c2)cc1 nan
CHEMBL1439624 62441 4 None -1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 384 4 0 0 7.0 c1ccc(-c2cc(-c3ccccc3)[n+](-c3ccccc3)c(-c3ccccc3)c2)cc1 nan
CHEMBL1621746 62441 4 None -1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 384 4 0 0 7.0 c1ccc(-c2cc(-c3ccccc3)[n+](-c3ccccc3)c(-c3ccccc3)c2)cc1 nan
16195600 53035 2 None -1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 320 3 2 5 2.5 O=C1NC(=O)C(=Cc2ccc(SC3CCCCC3)o2)C(=O)N1 nan
CHEMBL1535216 53035 2 None -1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 320 3 2 5 2.5 O=C1NC(=O)C(=Cc2ccc(SC3CCCCC3)o2)C(=O)N1 nan
2198843 26729 6 None -1 3 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 372 3 1 5 2.8 Cc1cccc(N2C(=O)NC(=O)/C(=C\c3cnn(-c4ccccc4)c3)C2=O)c1 nan
CHEMBL1302946 26729 6 None -1 3 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 372 3 1 5 2.8 Cc1cccc(N2C(=O)NC(=O)/C(=C\c3cnn(-c4ccccc4)c3)C2=O)c1 nan
4326878 38264 3 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 350 7 2 10 1.8 Cn1ccnc1Sc1cc(NCCCO)c([N+](=O)[O-])c2nonc12 nan
CHEMBL1403329 38264 3 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 350 7 2 10 1.8 Cn1ccnc1Sc1cc(NCCCO)c([N+](=O)[O-])c2nonc12 nan
5735866 35289 9 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 343 4 1 2 4.3 CC(=O)Nc1cccc(C(=O)/C=C/c2ccc(Br)cc2)c1 nan
CHEMBL1375998 35289 9 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 343 4 1 2 4.3 CC(=O)Nc1cccc(C(=O)/C=C/c2ccc(Br)cc2)c1 nan
145989745 173864 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GFP10-tagged human NTS1 expressed in CHO-K1 cells assessed as Rluc2-fused beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10-tagged human NTS1 expressed in CHO-K1 cells assessed as Rluc2-fused beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 782 13 7 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)CC=CCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.7b00500
CHEMBL4289739 173864 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GFP10-tagged human NTS1 expressed in CHO-K1 cells assessed as Rluc2-fused beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10-tagged human NTS1 expressed in CHO-K1 cells assessed as Rluc2-fused beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 782 13 7 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)CC=CCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.7b00500
145966776 171215 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 782 13 7 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCCC(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4213725 171215 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 782 13 7 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCCC(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
135871468 65999 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 493 6 1 5 5.9 COC(=O)C1=C(C)N(Cc2ccccc2)C(NCc2ccccc2)=N[C@H]1c1cccc(C(F)(F)F)c1 nan
CHEMBL1702299 65999 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 493 6 1 5 5.9 COC(=O)C1=C(C)N(Cc2ccccc2)C(NCc2ccccc2)=N[C@H]1c1cccc(C(F)(F)F)c1 nan
145972052 171297 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 841 13 9 10 2.2 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4214816 171297 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 841 13 9 10 2.2 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
745143 54401 8 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 337 6 0 5 4.0 CCOc1cc(/C=C2\C(=O)ON=C2C)ccc1OCc1ccccc1 nan
CHEMBL1546782 54401 8 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 337 6 0 5 4.0 CCOc1cc(/C=C2\C(=O)ON=C2C)ccc1OCc1ccccc1 nan
2834420 61829 4 None -1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 435 7 0 4 5.0 CC1CCC(C(C)C)C(OC(=O)Cn2c(COc3ccccc3)[n+](C)c3ccccc32)C1 nan
CHEMBL1325192 61829 4 None -1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 435 7 0 4 5.0 CC1CCC(C(C)C)C(OC(=O)Cn2c(COc3ccccc3)[n+](C)c3ccccc32)C1 nan
CHEMBL1616559 61829 4 None -1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 435 7 0 4 5.0 CC1CCC(C(C)C)C(OC(=O)Cn2c(COc3ccccc3)[n+](C)c3ccccc32)C1 nan
2827476 62031 6 None -1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 307 6 1 6 2.3 CC(=O)n1cc(C(C[N+](=O)[O-])SCCN)c2ccccc21 nan
CHEMBL1322180 62031 6 None -1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 307 6 1 6 2.3 CC(=O)n1cc(C(C[N+](=O)[O-])SCCN)c2ccccc21 nan
CHEMBL1618016 62031 6 None -1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 307 6 1 6 2.3 CC(=O)n1cc(C(C[N+](=O)[O-])SCCN)c2ccccc21 nan
4318511 61776 6 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 467 15 0 5 5.7 CCCCCCCCCCOC(=O)Cn1c(COc2cccc(OC)c2)[n+](C)c2ccccc21 nan
CHEMBL1338004 61776 6 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 467 15 0 5 5.7 CCCCCCCCCCOC(=O)Cn1c(COc2cccc(OC)c2)[n+](C)c2ccccc21 nan
CHEMBL1616169 61776 6 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 467 15 0 5 5.7 CCCCCCCCCCOC(=O)Cn1c(COc2cccc(OC)c2)[n+](C)c2ccccc21 nan
216239 30567 118 None -7 11 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 nan
CHEMBL1200485 30567 118 None -7 11 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 nan
CHEMBL1336 30567 118 None -7 11 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 464 5 3 4 5.6 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 nan
16746296 38439 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 513 9 0 6 6.5 COc1ccc(C(CCN2CCCCC2)c2c(OC)cc(OC)c3c(-c4ccccc4)cc(=O)oc23)cc1 nan
CHEMBL1405092 38439 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 513 9 0 6 6.5 COc1ccc(C(CCN2CCCCC2)c2c(OC)cc(OC)c3c(-c4ccccc4)cc(=O)oc23)cc1 nan
4316708 62476 3 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 327 5 0 2 4.8 O=C(c1ccc(Cl)cc1)C(CN1CCCCC1)c1ccccc1 nan
CHEMBL1482193 62476 3 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 327 5 0 2 4.8 O=C(c1ccc(Cl)cc1)C(CN1CCCCC1)c1ccccc1 nan
CHEMBL1622001 62476 3 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 327 5 0 2 4.8 O=C(c1ccc(Cl)cc1)C(CN1CCCCC1)c1ccccc1 nan
883995 30389 27 None -1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 264 4 0 2 3.9 Cc1ccc(C(=O)/C=C/C(=O)c2ccc(C)cc2)cc1 nan
CHEMBL1334520 30389 27 None -1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 264 4 0 2 3.9 Cc1ccc(C(=O)/C=C/C(=O)c2ccc(C)cc2)cc1 nan
145976898 170611 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 841 29 9 10 2.2 C=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)c(CC=C)c1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b00175
CHEMBL4206391 170611 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 841 29 9 10 2.2 C=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)c(CC=C)c1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b00175
145977513 170345 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 827 13 9 10 1.8 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4203162 170345 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 827 13 9 10 1.8 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
145977513 170345 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 827 13 9 10 1.8 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4203162 170345 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 827 13 9 10 1.8 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
145966776 171215 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 782 13 7 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCCC(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4213725 171215 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 782 13 7 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCCC(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
136601019 38523 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 343 4 1 4 3.9 CC(C)CN1C(=O)/C(=C/c2c[nH]nc2-c2ccccc2)SC1=S nan
CHEMBL1405919 38523 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 343 4 1 4 3.9 CC(C)CN1C(=O)/C(=C/c2c[nH]nc2-c2ccccc2)SC1=S nan
CHEMBL508380 221662 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)N=[N+]=[N-])C(C)(C)C)C(=O)O 10.1021/jm801072v
8177748 33782 16 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 271 4 0 3 3.6 O=C(/C=C/c1ccccc1F)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1364769 33782 16 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 271 4 0 3 3.6 O=C(/C=C/c1ccccc1F)c1cccc([N+](=O)[O-])c1 nan
910773 45592 9 None 1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 318 3 1 3 2.9 O=C1NC(=O)N(c2ccccc2)C(=O)/C1=C\C=C\c1ccccc1 nan
CHEMBL1466699 45592 9 None 1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 318 3 1 3 2.9 O=C1NC(=O)N(c2ccccc2)C(=O)/C1=C\C=C\c1ccccc1 nan
3947745 42311 3 None -1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 424 7 3 2 5.9 OC(CNCC(c1ccc(Cl)cc1Cl)c1c[nH]c2ccccc12)c1ccccc1 nan
CHEMBL1438983 42311 3 None -1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 424 7 3 2 5.9 OC(CNCC(c1ccc(Cl)cc1Cl)c1c[nH]c2ccccc12)c1ccccc1 nan
16746323 30211 0 None 1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 507 12 0 6 6.6 CCCCCc1cc(=O)oc2c(C(CCN3CCCCC3)c3ccc(OC)cc3)c(OC)cc(OC)c12 nan
CHEMBL1333191 30211 0 None 1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 507 12 0 6 6.6 CCCCCc1cc(=O)oc2c(C(CCN3CCCCC3)c3ccc(OC)cc3)c(OC)cc(OC)c12 nan
1187240 51761 15 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 358 4 2 6 4.7 O=[N+]([O-])c1ccc(-c2nc(Nc3cccc(O)c3)c3ccccc3n2)cc1 nan
CHEMBL1523597 51761 15 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 358 4 2 6 4.7 O=[N+]([O-])c1ccc(-c2nc(Nc3cccc(O)c3)c3ccccc3n2)cc1 nan
118708033 120068 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 365 7 2 4 3.3 CC(C)C[C@H](NC(=O)Cn1ccc2cc(-c3cccnc3)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL3315198 120068 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 365 7 2 4 3.3 CC(C)C[C@H](NC(=O)Cn1ccc2cc(-c3cccnc3)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
42600970 66812 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 397 9 1 5 6.4 CCCCNc1c(-c2ccc(OC)c(SC(C)CC)c2)nc2ccc(C)cn12 nan
CHEMBL1736159 66812 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 397 9 1 5 6.4 CCCCNc1c(-c2ccc(OC)c(SC(C)CC)c2)nc2ccc(C)cn12 nan
CHEMBL2141549 66812 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 397 9 1 5 6.4 CCCCNc1c(-c2ccc(OC)c(SC(C)CC)c2)nc2ccc(C)cn12 nan
25102555 66102 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 369 5 1 3 6.0 CC(C)C[C@H]1CN=C(Nc2ccccc2)N1CC1CCC(C(C)(C)C)CC1 nan
CHEMBL1706262 66102 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 369 5 1 3 6.0 CC(C)C[C@H]1CN=C(Nc2ccccc2)N1CC1CCC(C(C)(C)C)CC1 nan
3092507 61980 8 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 467 15 0 5 5.7 CCCCCCCCCCOC(=O)Cn1c(COc2ccc(OC)cc2)[n+](C)c2ccccc21 nan
CHEMBL1328510 61980 8 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 467 15 0 5 5.7 CCCCCCCCCCOC(=O)Cn1c(COc2ccc(OC)cc2)[n+](C)c2ccccc21 nan
CHEMBL1617738 61980 8 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 467 15 0 5 5.7 CCCCCCCCCCOC(=O)Cn1c(COc2ccc(OC)cc2)[n+](C)c2ccccc21 nan
5734448 28499 13 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 414 5 0 4 5.3 O=C(Oc1ccc(Br)cc1C(=O)/C=C/c1ccccc1F)c1ccco1 nan
CHEMBL1318749 28499 13 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 414 5 0 4 5.3 O=C(Oc1ccc(Br)cc1C(=O)/C=C/c1ccccc1F)c1ccco1 nan
1832662 40267 17 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 403 5 0 7 3.9 COc1cccc(OC)c1C(=O)Oc1ccc2c(c1)O/C(=C\c1ccncc1)C2=O nan
CHEMBL1420229 40267 17 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 403 5 0 7 3.9 COc1cccc(OC)c1C(=O)Oc1ccc2c(c1)O/C(=C\c1ccncc1)C2=O nan
135458768 114907 5 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 380 5 2 5 5.4 C/C(=N/Nc1cc(-c2ccccc2)nc(-c2ccccc2)n1)c1ccc(O)cc1 nan
CHEMBL3195813 114907 5 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 380 5 2 5 5.4 C/C(=N/Nc1cc(-c2ccccc2)nc(-c2ccccc2)n1)c1ccc(O)cc1 nan
677881 47938 24 None -6 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 238 2 0 3 3.0 O=CC1=C(c2ccccc2)Oc2ccccc2O1 nan
CHEMBL1488408 47938 24 None -6 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 238 2 0 3 3.0 O=CC1=C(c2ccccc2)Oc2ccccc2O1 nan
1270554 49002 11 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 478 6 1 6 5.3 CCOC(=O)c1cc(-c2ccc(/C=C3/C(=O)N(c4ccc(C(=O)O)cc4)N=C3C)o2)ccc1Cl nan
CHEMBL1497243 49002 11 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 478 6 1 6 5.3 CCOC(=O)c1cc(-c2ccc(/C=C3/C(=O)N(c4ccc(C(=O)O)cc4)N=C3C)o2)ccc1Cl nan
9551283 46091 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 355 6 0 5 4.1 CCOc1cc(/C=C2/C(=O)ON=C2C)ccc1OCc1ccc(F)cc1 nan
CHEMBL1470914 46091 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 355 6 0 5 4.1 CCOc1cc(/C=C2/C(=O)ON=C2C)ccc1OCc1ccc(F)cc1 nan
2092791 33211 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 415 6 1 7 3.1 CC(C)Cn1c(N)c(C(=O)CSc2cc(Cl)ccc2Cl)c(=O)n(C)c1=O nan
CHEMBL1359756 33211 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 415 6 1 7 3.1 CC(C)Cn1c(N)c(C(=O)CSc2cc(Cl)ccc2Cl)c(=O)n(C)c1=O nan
145966776 171215 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 782 13 7 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCCC(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4213725 171215 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 782 13 7 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCCC(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
145989745 173864 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cells assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cells assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 782 13 7 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)CC=CCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.7b00500
CHEMBL4289739 173864 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cells assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cells assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 782 13 7 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)CC=CCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.7b00500
42628219 56064 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 479 3 0 4 4.8 O=C1c2ccc(Cl)cc2S(=O)(=O)c2cccc(C(=O)N3CCC(Cc4ccccc4)CC3)c21 nan
CHEMBL1563372 56064 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 479 3 0 4 4.8 O=C1c2ccc(Cl)cc2S(=O)(=O)c2cccc(C(=O)N3CCC(Cc4ccccc4)CC3)c21 nan
5508807 43867 5 None -6 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 362 3 1 4 4.1 CC1=NNC(=O)/C1=C\c1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1 nan
CHEMBL1452379 43867 5 None -6 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 362 3 1 4 4.1 CC1=NNC(=O)/C1=C\c1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1 nan
16195113 62271 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 340 5 2 3 4.1 Cc1ccc2c(c1)c1c(n2CC(O)CNC2CCCCC2)CCCC1 nan
CHEMBL1419585 62271 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 340 5 2 3 4.1 Cc1ccc2c(c1)c1c(n2CC(O)CNC2CCCCC2)CCCC1 nan
CHEMBL1620130 62271 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 340 5 2 3 4.1 Cc1ccc2c(c1)c1c(n2CC(O)CNC2CCCCC2)CCCC1 nan
9645147 78891 6 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 394 5 2 5 4.0 O=C(N/N=C/c1ccc(OC(=O)c2ccccc2Cl)cc1)c1ccc(O)cc1 nan
CHEMBL1978125 78891 6 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 394 5 2 5 4.0 O=C(N/N=C/c1ccc(OC(=O)c2ccccc2Cl)cc1)c1ccc(O)cc1 nan
1081942 37032 8 None -4 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 432 6 1 6 2.4 CCOC(=O)c1ccc(NC(=O)c2ccc(C)c(S(=O)(=O)N3CCOCC3)c2)cc1 nan
CHEMBL1390986 37032 8 None -4 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 432 6 1 6 2.4 CCOC(=O)c1ccc(NC(=O)c2ccc(C)c(S(=O)(=O)N3CCOCC3)c2)cc1 nan
2199938 32169 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 347 2 1 3 4.0 Cc1cc(Br)c2c(c1)/C(=C/C(=O)c1cccs1)C(=O)N2 nan
CHEMBL1349747 32169 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 347 2 1 3 4.0 Cc1cc(Br)c2c(c1)/C(=C/C(=O)c1cccs1)C(=O)N2 nan
3240356 43431 7 None -1 3 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 478 8 1 7 2.4 COC(=O)c1ccc2c(=O)n(CCCCCC(=O)N3CCN(c4ccccc4)CC3)c(=O)[nH]c2c1 nan
CHEMBL1448941 43431 7 None -1 3 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 478 8 1 7 2.4 COC(=O)c1ccc2c(=O)n(CCCCCC(=O)N3CCN(c4ccccc4)CC3)c(=O)[nH]c2c1 nan
135650114 79523 14 None 1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 432 7 2 8 3.2 COc1cc(/C=N/Nc2nc(-c3ccc(S(=O)(=O)N(C)C)cc3)cs2)ccc1O nan
CHEMBL1998816 79523 14 None 1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 432 7 2 8 3.2 COc1cc(/C=N/Nc2nc(-c3ccc(S(=O)(=O)N(C)C)cc3)cs2)ccc1O nan
16746392 43832 0 None 1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 534 12 0 6 6.9 CCCCCc1cc(=O)oc2c(C(CCN3CCCC(C)C3)c3ccc(N(C)C)cc3)c(OC)cc(OC)c12 nan
CHEMBL1452114 43832 0 None 1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 534 12 0 6 6.9 CCCCCc1cc(=O)oc2c(C(CCN3CCCC(C)C3)c3ccc(N(C)C)cc3)c(OC)cc(OC)c12 nan
977927 54113 8 None -12 4 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 283 3 1 3 3.5 CCc1ccc2c(c1)/C(=C/C(=O)c1cccs1)C(=O)N2 nan
CHEMBL1544423 54113 8 None -12 4 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 283 3 1 3 3.5 CCc1ccc2c(c1)/C(=C/C(=O)c1cccs1)C(=O)N2 nan
1610853 62604 9 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 296 7 1 2 5.0 CCCCCCCCn1c2c(c(=N)c3ccccc31)CCC2 nan
CHEMBL1518625 62604 9 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 296 7 1 2 5.0 CCCCCCCCn1c2c(c(=N)c3ccccc31)CCC2 nan
CHEMBL1623084 62604 9 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 296 7 1 2 5.0 CCCCCCCCn1c2c(c(=N)c3ccccc31)CCC2 nan
16114081 184167 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL 494 9 3 6 3.6 CC(C)C[C@H](NC(=O)Cn1ccc2cc(NS(=O)(=O)c3cccc4cccnc34)ccc21)C(=O)O 10.1016/j.bmcl.2009.01.024
CHEMBL463811 184167 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL 494 9 3 6 3.6 CC(C)C[C@H](NC(=O)Cn1ccc2cc(NS(=O)(=O)c3cccc4cccnc34)ccc21)C(=O)O 10.1016/j.bmcl.2009.01.024
1811598 38972 5 None -1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 404 9 1 4 3.5 CN(C(=O)COc1ccccc1C(=O)NCCOc1ccccc1)c1ccccc1 nan
CHEMBL1409423 38972 5 None -1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 404 9 1 4 3.5 CN(C(=O)COc1ccccc1C(=O)NCCOc1ccccc1)c1ccccc1 nan
16746616 50589 0 None 1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 448 7 3 5 3.7 Cc1cccc(NC(=O)c2[nH]cnc2C(=O)N[C@@H](Cc2ccccc2)C(=O)OC(C)(C)C)c1 nan
CHEMBL1511193 50589 0 None 1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 448 7 3 5 3.7 Cc1cccc(NC(=O)c2[nH]cnc2C(=O)N[C@@H](Cc2ccccc2)C(=O)OC(C)(C)C)c1 nan
6616154 92264 4 None 1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 484 7 2 5 4.6 CC1CCN(CCCNC(=O)c2ccc3c(=O)n(Cc4ccc(Cl)cc4)c(=S)[nH]c3c2)CC1 nan
CHEMBL226876 92264 4 None 1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 484 7 2 5 4.6 CC1CCN(CCCNC(=O)c2ccc3c(=O)n(Cc4ccc(Cl)cc4)c(=S)[nH]c3c2)CC1 nan
145966676 171027 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 784 13 9 10 0.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4211344 171027 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 784 13 9 10 0.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
2968891 33438 8 None -1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 458 5 0 4 4.4 O=C(CN(C(=O)c1ccc(Cl)cc1)N1C(=O)C2CCCCC2C1=O)c1ccc(Cl)cc1 nan
CHEMBL1361814 33438 8 None -1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 458 5 0 4 4.4 O=C(CN(C(=O)c1ccc(Cl)cc1)N1C(=O)C2CCCCC2C1=O)c1ccc(Cl)cc1 nan
2177873 34580 6 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 365 4 0 3 3.5 CCN1C(=O)/C(=C/N(C(C)=O)c2ccccc2)N(c2ccccc2)C1=S nan
CHEMBL1370953 34580 6 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 365 4 0 3 3.5 CCN1C(=O)/C(=C/N(C(C)=O)c2ccccc2)N(c2ccccc2)C1=S nan
145964771 170974 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4210760 170974 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
9550901 54722 8 None -1 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 463 3 1 5 4.7 CC1=C(C(=O)OC2CCCCCCC2)C(c2cc3c(cc2Br)OCO3)CC(=O)N1 nan
CHEMBL1549706 54722 8 None -1 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 463 3 1 5 4.7 CC1=C(C(=O)OC2CCCCCCC2)C(c2cc3c(cc2Br)OCO3)CC(=O)N1 nan
11957215 62531 3 None -22 4 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 336 3 1 3 3.9 COC(=O)c1ccc2c(c1)C(C)(C)C(/C=C/c1ccccc1O)=[N+]2C nan
CHEMBL1503962 62531 3 None -22 4 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 336 3 1 3 3.9 COC(=O)c1ccc2c(c1)C(C)(C)C(/C=C/c1ccccc1O)=[N+]2C nan
CHEMBL1622468 62531 3 None -22 4 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 336 3 1 3 3.9 COC(=O)c1ccc2c(c1)C(C)(C)C(/C=C/c1ccccc1O)=[N+]2C nan
1255859 35776 12 None 1 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 443 4 1 5 3.7 CC(C)C(=O)N1CCN(c2ccc(NC(=O)c3ccc4c(c3)OCCO4)cc2Cl)CC1 nan
CHEMBL1380459 35776 12 None 1 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 443 4 1 5 3.7 CC(C)C(=O)N1CCN(c2ccc(NC(=O)c3ccc4c(c3)OCCO4)cc2Cl)CC1 nan
2891887 62148 6 None -2 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 494 7 1 5 4.7 O=C1c2cccc3cccc(c23)C(=O)N1CC1CCN(CC(O)COc2ccc3ccccc3c2)CC1 nan
CHEMBL1380969 62148 6 None -2 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 494 7 1 5 4.7 O=C1c2cccc3cccc(c23)C(=O)N1CC1CCN(CC(O)COc2ccc3ccccc3c2)CC1 nan
CHEMBL1619128 62148 6 None -2 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 494 7 1 5 4.7 O=C1c2cccc3cccc(c23)C(=O)N1CC1CCN(CC(O)COc2ccc3ccccc3c2)CC1 nan
CHEMBL501956 220926 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@](C)(N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/jm801072v
2892067 62339 8 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 472 7 1 5 4.2 Cc1cc(C)cc(OCC(O)CN2CCC(CN3C(=O)c4cccc5cccc(c45)C3=O)CC2)c1 nan
CHEMBL1450446 62339 8 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 472 7 1 5 4.2 Cc1cc(C)cc(OCC(O)CN2CCC(CN3C(=O)c4cccc5cccc(c45)C3=O)CC2)c1 nan
CHEMBL1620833 62339 8 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 472 7 1 5 4.2 Cc1cc(C)cc(OCC(O)CN2CCC(CN3C(=O)c4cccc5cccc(c45)C3=O)CC2)c1 nan
6218006 65910 4 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 388 7 2 7 1.8 COC(=O)c1ccc(/C=C/C(=O)OCC(=O)Nc2sccc2C(N)=O)cc1 nan
CHEMBL1698682 65910 4 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 388 7 2 7 1.8 COC(=O)c1ccc(/C=C/C(=O)OCC(=O)Nc2sccc2C(N)=O)cc1 nan
9590748 115426 4 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 347 9 2 7 2.8 CCCCCCOc1ccc(/C(C)=N/NC2=NCCN2)cc1[N+](=O)[O-] nan
CHEMBL3207463 115426 4 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 347 9 2 7 2.8 CCCCCCOc1ccc(/C(C)=N/NC2=NCCN2)cc1[N+](=O)[O-] nan
145966676 171027 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 784 13 9 10 0.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4211344 171027 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 784 13 9 10 0.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
3837201 30353 7 None -4 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 489 4 1 5 6.0 O=C(Nc1ccc(Oc2c(F)c(F)c(F)c(F)c2F)cc1)OC1CCN2Cc3ccccc3N=C12 nan
CHEMBL1334291 30353 7 None -4 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 489 4 1 5 6.0 O=C(Nc1ccc(Oc2c(F)c(F)c(F)c(F)c2F)cc1)OC1CCN2Cc3ccccc3N=C12 nan
1922630 50446 8 None -4 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 350 4 1 4 3.6 CC(C)c1ccc(N2C(=O)NC(=O)/C(=C\C=C\c3ccco3)C2=O)cc1 nan
CHEMBL1509980 50446 8 None -4 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 350 4 1 4 3.6 CC(C)c1ccc(N2C(=O)NC(=O)/C(=C\C=C\c3ccco3)C2=O)cc1 nan
135651354 78703 5 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 369 6 3 6 2.7 COc1cc(OC)c2cc(C(=O)N/N=C/c3cccc(OC)c3O)[nH]c2c1 nan
CHEMBL1972217 78703 5 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 369 6 3 6 2.7 COc1cc(OC)c2cc(C(=O)N/N=C/c3cccc(OC)c3O)[nH]c2c1 nan
24860305 66581 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 535 10 4 7 3.2 C[C@H](NC(=O)c1[nH]cnc1C(=O)NCc1ccc(CNC(=O)OC(C)(C)C)cc1)C(=O)OCc1ccccc1 nan
CHEMBL1727210 66581 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 535 10 4 7 3.2 C[C@H](NC(=O)c1[nH]cnc1C(=O)NCc1ccc(CNC(=O)OC(C)(C)C)cc1)C(=O)OCc1ccccc1 nan
789621 201787 10 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 340 3 2 4 4.9 Oc1ccc(-c2cc(-c3ccc(O)cc3)nc(-c3ccccc3)n2)cc1 nan
CHEMBL548458 201787 10 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 340 3 2 4 4.9 Oc1ccc(-c2cc(-c3ccc(O)cc3)nc(-c3ccccc3)n2)cc1 nan
4837288 42943 9 None 1 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 394 5 1 4 5.4 c1ccc(CN2CCC(Nc3nc(-c4ccccc4)nc4ccccc34)CC2)cc1 nan
CHEMBL1444767 42943 9 None 1 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 394 5 1 4 5.4 c1ccc(CN2CCC(Nc3nc(-c4ccccc4)nc4ccccc34)CC2)cc1 nan
2832800 60022 17 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 452 3 1 5 5.4 CC1(C)CC(=O)C(C(C2=C(O)CC(C)(C)CC2=O)c2ccc(Br)s2)C(=O)C1 nan
CHEMBL1599120 60022 17 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 452 3 1 5 5.4 CC1(C)CC(=O)C(C(C2=C(O)CC(C)(C)CC2=O)c2ccc(Br)s2)C(=O)C1 nan
5024835 47365 6 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 426 10 0 7 4.0 CCCOc1ccc(C(=O)c2ccccc2C(=O)OC2CCOC2=O)cc1OCCC nan
CHEMBL1483683 47365 6 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 426 10 0 7 4.0 CCCOc1ccc(C(=O)c2ccccc2C(=O)OC2CCOC2=O)cc1OCCC nan
2882627 62408 6 None -6 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 357 9 2 3 4.3 CC(NCC(O)COCCC12CC3CC(CC(C3)C1)C2)c1ccccc1 nan
CHEMBL1458403 62408 6 None -6 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 357 9 2 3 4.3 CC(NCC(O)COCCC12CC3CC(CC(C3)C1)C2)c1ccccc1 nan
CHEMBL1621400 62408 6 None -6 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 357 9 2 3 4.3 CC(NCC(O)COCCC12CC3CC(CC(C3)C1)C2)c1ccccc1 nan
42628331 66283 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 368 5 3 3 3.8 C[C@@H](NC(=O)c1[nH]cnc1C(=O)Nc1ccc(Cl)cc1)c1ccccc1 nan
CHEMBL1715091 66283 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 368 5 3 3 3.8 C[C@@H](NC(=O)c1[nH]cnc1C(=O)Nc1ccc(Cl)cc1)c1ccccc1 nan
1574 9585 20 None -50 6 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at NTR1 in mouse N1E-115 cells assessed as increase in intracellular calcium concentrationAgonist activity at NTR1 in mouse N1E-115 cells assessed as increase in intracellular calcium concentration
ChEMBL None None None None 10.1021/jm801072v
1579 9585 20 None -50 6 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at NTR1 in mouse N1E-115 cells assessed as increase in intracellular calcium concentrationAgonist activity at NTR1 in mouse N1E-115 cells assessed as increase in intracellular calcium concentration
ChEMBL None None None None 10.1021/jm801072v
25077406 9585 20 None -50 6 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at NTR1 in mouse N1E-115 cells assessed as increase in intracellular calcium concentrationAgonist activity at NTR1 in mouse N1E-115 cells assessed as increase in intracellular calcium concentration
ChEMBL None None None None 10.1021/jm801072v
3830 9585 20 None -50 6 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at NTR1 in mouse N1E-115 cells assessed as increase in intracellular calcium concentrationAgonist activity at NTR1 in mouse N1E-115 cells assessed as increase in intracellular calcium concentration
ChEMBL None None None None 10.1021/jm801072v
CHEMBL407196 9585 20 None -50 6 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at NTR1 in mouse N1E-115 cells assessed as increase in intracellular calcium concentrationAgonist activity at NTR1 in mouse N1E-115 cells assessed as increase in intracellular calcium concentration
ChEMBL None None None None 10.1021/jm801072v
127032412 145978 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3785364 145978 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3786291 145978 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3787706 145978 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL4579623 145978 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysisAgonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
1574 9585 20 None -26 6 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human NTR1 assessed as increase in intracellular calcium concentrationAgonist activity at human NTR1 assessed as increase in intracellular calcium concentration
ChEMBL None None None None 10.1021/jm801072v
1579 9585 20 None -26 6 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human NTR1 assessed as increase in intracellular calcium concentrationAgonist activity at human NTR1 assessed as increase in intracellular calcium concentration
ChEMBL None None None None 10.1021/jm801072v
25077406 9585 20 None -26 6 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human NTR1 assessed as increase in intracellular calcium concentrationAgonist activity at human NTR1 assessed as increase in intracellular calcium concentration
ChEMBL None None None None 10.1021/jm801072v
3830 9585 20 None -26 6 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human NTR1 assessed as increase in intracellular calcium concentrationAgonist activity at human NTR1 assessed as increase in intracellular calcium concentration
ChEMBL None None None None 10.1021/jm801072v
CHEMBL407196 9585 20 None -26 6 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human NTR1 assessed as increase in intracellular calcium concentrationAgonist activity at human NTR1 assessed as increase in intracellular calcium concentration
ChEMBL None None None None 10.1021/jm801072v
CHEMBL266571 217468 2 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL None None None CN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
53245590 99174 43 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 420 6 0 7 3.9 COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1016/j.bmcl.2014.06.033
CHEMBL2431120 99174 43 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 420 6 0 7 3.9 COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1016/j.bmcl.2014.06.033
145964771 170974 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4210760 170974 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
44564776 184312 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL 462 7 2 5 5.0 CC(C)C[C@H](NC(=O)c1cc(-c2ccccc2)n(-c2ccnc3cc(Cl)ccc23)n1)C(=O)O 10.1016/j.bmcl.2009.01.024
CHEMBL464011 184312 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL 462 7 2 5 5.0 CC(C)C[C@H](NC(=O)c1cc(-c2ccccc2)n(-c2ccnc3cc(Cl)ccc23)n1)C(=O)O 10.1016/j.bmcl.2009.01.024
118708030 120063 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 415 7 2 4 4.5 CC(C)C[C@H](NC(=O)Cn1ccc2cc(-c3cnc4ccccc4c3)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL3315193 120063 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 415 7 2 4 4.5 CC(C)C[C@H](NC(=O)Cn1ccc2cc(-c3cnc4ccccc4c3)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
2998956 32301 6 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 424 7 1 6 2.8 CCCCn1c(SCC(=O)N2CCC(C)CC2)nc2cc(S(N)(=O)=O)ccc21 nan
CHEMBL1350888 32301 6 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 424 7 1 6 2.8 CCCCn1c(SCC(=O)N2CCC(C)CC2)nc2cc(S(N)(=O)=O)ccc21 nan
145970755 171559 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4218115 171559 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
118708041 120076 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 585 11 2 6 6.6 CC(C)C[C@H](NC(=O)Cn1ccc2cc(N(Cc3ccnc4ccccc34)Cc3ccnc4ccccc34)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL3315206 120076 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 585 11 2 6 6.6 CC(C)C[C@H](NC(=O)Cn1ccc2cc(N(Cc3ccnc4ccccc34)Cc3ccnc4ccccc34)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
1520390 58605 11 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 446 5 0 7 5.0 COc1ccc(-c2csc(N3CCN(c4cc(C)nc5ccccc45)CC3)n2)cc1OC nan
CHEMBL1585318 58605 11 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 446 5 0 7 5.0 COc1ccc(-c2csc(N3CCN(c4cc(C)nc5ccccc45)CC3)n2)cc1OC nan
3314979 62278 4 None -2 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 333 8 2 3 4.2 CC1CCC(C(C)C)C(OCC(O)CNC(C)c2ccccc2)C1 nan
CHEMBL1422262 62278 4 None -2 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 333 8 2 3 4.2 CC1CCC(C(C)C)C(OCC(O)CNC(C)c2ccccc2)C1 nan
CHEMBL1620234 62278 4 None -2 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 333 8 2 3 4.2 CC1CCC(C(C)C)C(OCC(O)CNC(C)c2ccccc2)C1 nan
4308 107870 53 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL 353 6 2 3 4.0 CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O 10.1016/j.bmcl.2009.01.024
CHEMBL294989 107870 53 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL 353 6 2 3 4.0 CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O 10.1016/j.bmcl.2009.01.024
CHEMBL445035 220716 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/jm801072v
44157040 183792 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL 492 8 2 6 5.0 COc1ccccc1-c1cc(C(=O)N[C@@H](CC(C)C)C(=O)O)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2009.01.024
CHEMBL462830 183792 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL 492 8 2 6 5.0 COc1ccccc1-c1cc(C(=O)N[C@@H](CC(C)C)C(=O)O)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2009.01.024
44157040 183792 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 492 8 2 6 5.0 COc1ccccc1-c1cc(C(=O)N[C@@H](CC(C)C)C(=O)O)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2014.06.033
CHEMBL462830 183792 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 492 8 2 6 5.0 COc1ccccc1-c1cc(C(=O)N[C@@H](CC(C)C)C(=O)O)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2014.06.033
4886081 52340 12 None -2 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 507 1 1 5 5.4 Cc1cc2c3c(c1)C(C)(c1ccccc1)CC(C)(C)N3C(=O)C21C(C#N)=C(N)OC2=C1C(=O)CC(C)(C)C2 nan
CHEMBL1528880 52340 12 None -2 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 507 1 1 5 5.4 Cc1cc2c3c(c1)C(C)(c1ccccc1)CC(C)(C)N3C(=O)C21C(C#N)=C(N)OC2=C1C(=O)CC(C)(C)C2 nan
1782673 27669 2 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 248 3 0 4 2.1 Cc1cc(N2CCOCC2)ccc1/C=C\[N+](=O)[O-] nan
CHEMBL1310644 27669 2 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 248 3 0 4 2.1 Cc1cc(N2CCOCC2)ccc1/C=C\[N+](=O)[O-] nan
2829042 40385 13 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 486 10 2 7 3.9 CCOC(=O)c1c(NC(C)=O)sc2c(OCC(O)CN(CC)CC)c(Br)ccc12 nan
CHEMBL1421296 40385 13 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 486 10 2 7 3.9 CCOC(=O)c1c(NC(C)=O)sc2c(OCC(O)CN(CC)CC)c(Br)ccc12 nan
745141 41298 9 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 337 6 0 5 4.0 CCOc1cc(/C=C2/C(=O)ON=C2C)ccc1OCc1ccccc1 nan
CHEMBL1429003 41298 9 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 337 6 0 5 4.0 CCOc1cc(/C=C2/C(=O)ON=C2C)ccc1OCc1ccccc1 nan
135549626 114664 5 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 339 6 4 5 1.4 O=C(/C=C\c1ccccc1)NCC(=O)N/N=C/c1ccc(O)cc1O nan
CHEMBL3192903 114664 5 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 339 6 4 5 1.4 O=C(/C=C\c1ccccc1)NCC(=O)N/N=C/c1ccc(O)cc1O nan
145976418 170665 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 798 13 8 9 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCCCC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4206981 170665 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 798 13 8 9 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCCCC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
145977513 170345 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 827 13 9 10 1.8 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4203162 170345 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 827 13 9 10 1.8 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
145972052 171297 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 841 13 9 10 2.2 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4214816 171297 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 841 13 9 10 2.2 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
2136907 49474 13 None 10 2 Human 5.6 pEC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 427 5 0 5 5.7 COc1cc2c3nnc(-c4ccc(F)cc4)c-3cn(Cc3ccc(C)cc3)c2cc1OC nan
CHEMBL1501508 49474 13 None 10 2 Human 5.6 pEC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 427 5 0 5 5.7 COc1cc2c3nnc(-c4ccc(F)cc4)c-3cn(Cc3ccc(C)cc3)c2cc1OC nan
42628330 39895 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 368 5 3 3 3.8 C[C@H](NC(=O)c1[nH]cnc1C(=O)Nc1cccc(Cl)c1)c1ccccc1 nan
CHEMBL1417142 39895 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 368 5 3 3 3.8 C[C@H](NC(=O)c1[nH]cnc1C(=O)Nc1cccc(Cl)c1)c1ccccc1 nan
118708040 120075 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 451 10 3 5 3.4 COc1cccc(CC(=O)Nc2ccc3c(ccn3CC(=O)N[C@@H](CC(C)C)C(=O)O)c2)c1 10.1016/j.bmcl.2014.06.033
CHEMBL3315205 120075 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 451 10 3 5 3.4 COc1cccc(CC(=O)Nc2ccc3c(ccn3CC(=O)N[C@@H](CC(C)C)C(=O)O)c2)c1 10.1016/j.bmcl.2014.06.033
6228509 57976 8 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 309 4 1 4 2.9 COc1ccc(C(=O)/C=C2/C(=O)Nc3ccccc32)c(OC)c1 nan
CHEMBL1580134 57976 8 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 309 4 1 4 2.9 COc1ccc(C(=O)/C=C2/C(=O)Nc3ccccc32)c(OC)c1 nan
2236635 40405 12 None -1 3 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 425 4 1 4 4.6 O=C(Nc1ccc(N2CCN(C(=O)c3ccccc3)CC2)cc1)c1cc2ccccc2o1 nan
CHEMBL1421442 40405 12 None -1 3 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 425 4 1 4 4.6 O=C(Nc1ccc(N2CCN(C(=O)c3ccccc3)CC2)cc1)c1cc2ccccc2o1 nan
44572622 179476 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL 787 23 10 9 1.2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL450258 179476 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL 787 23 10 9 1.2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
3689411 42664 6 None 5 2 Human 5.6 pEC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 446 8 1 3 5.1 O=C(NCCc1ccccc1)C(c1cccs1)N(C(=O)CCl)c1ccc(Cl)cc1 nan
CHEMBL1442136 42664 6 None 5 2 Human 5.6 pEC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 446 8 1 3 5.1 O=C(NCCc1ccccc1)C(c1cccs1)N(C(=O)CCl)c1ccc(Cl)cc1 nan
2864688 43208 9 None -28 5 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 473 4 1 4 4.6 NS(=O)(=O)c1ccc(N2N=C(c3ccc(Br)cc3)CC2c2ccc(F)cc2)cc1 nan
CHEMBL1447076 43208 9 None -28 5 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 473 4 1 4 4.6 NS(=O)(=O)c1ccc(N2N=C(c3ccc(Br)cc3)CC2c2ccc(F)cc2)cc1 nan
8178372 60081 2 None -5 3 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 282 3 1 2 4.1 O=C(/C=C/c1cccc(Cl)c1)c1nc2ccccc2[nH]1 nan
CHEMBL1599610 60081 2 None -5 3 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 282 3 1 2 4.1 O=C(/C=C/c1cccc(Cl)c1)c1nc2ccccc2[nH]1 nan
118708031 120066 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 303 6 3 4 1.8 CC(C)C[C@H](NC(=O)Cn1ccc2cc(N)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL3315196 120066 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 303 6 3 4 1.8 CC(C)C[C@H](NC(=O)Cn1ccc2cc(N)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
145976898 170611 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 841 29 9 10 2.2 C=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)c(CC=C)c1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b00175
CHEMBL4206391 170611 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 841 29 9 10 2.2 C=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)c(CC=C)c1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b00175
634713 43403 11 None -13 2 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 428 4 1 8 4.2 Cc1cc(C)n(-c2nc(Nc3ccccc3C(F)(F)F)nc(-n3nc(C)cc3C)n2)n1 nan
CHEMBL1448732 43403 11 None -13 2 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 428 4 1 8 4.2 Cc1cc(C)n(-c2nc(Nc3ccccc3C(F)(F)F)nc(-n3nc(C)cc3C)n2)n1 nan
776319 52659 14 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 326 3 0 5 3.9 Cc1ccc(Sc2c([N+](=O)[O-])c(=O)n(C)c3ccccc23)cc1 nan
CHEMBL1531686 52659 14 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 326 3 0 5 3.9 Cc1ccc(Sc2c([N+](=O)[O-])c(=O)n(C)c3ccccc23)cc1 nan
1894824 60844 10 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 420 4 0 6 4.2 c1ccc(C(c2ccccc2)N2CCN(c3nc4ccccc4n4cnnc34)CC2)cc1 nan
CHEMBL1606390 60844 10 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 420 4 0 6 4.2 c1ccc(C(c2ccccc2)N2CCN(c3nc4ccccc4n4cnnc34)CC2)cc1 nan
25058324 66564 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 372 3 1 5 3.3 COc1ccc2sc(-c3ccc(S(C)(=O)=O)cc3)c(C#CCO)c2c1 nan
CHEMBL1726559 66564 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 372 3 1 5 3.3 COc1ccc2sc(-c3ccc(S(C)(=O)=O)cc3)c(C#CCO)c2c1 nan
145975635 170565 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 826 13 8 9 3.3 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCC[C@](C)(N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4205887 170565 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 826 13 8 9 3.3 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCC[C@](C)(N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
16127648 21137 0 None -2 3 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat NTR1 expressed in LTK cells assessed as calcium mobilizationAgonist activity at rat NTR1 expressed in LTK cells assessed as calcium mobilization
ChEMBL 817 22 9 8 1.4 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O 10.1021/jm100092s
CHEMBL1172376 21137 0 None -2 3 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat NTR1 expressed in LTK cells assessed as calcium mobilizationAgonist activity at rat NTR1 expressed in LTK cells assessed as calcium mobilization
ChEMBL 817 22 9 8 1.4 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O 10.1021/jm100092s
CHEMBL1200171 21137 0 None -2 3 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat NTR1 expressed in LTK cells assessed as calcium mobilizationAgonist activity at rat NTR1 expressed in LTK cells assessed as calcium mobilization
ChEMBL 817 22 9 8 1.4 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O 10.1021/jm100092s
4475102 60274 26 None - 1 Human 5.6 pEC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 432 3 7 10 0.1 O=c1cc(-c2ccc(O)cc2)oc2cc(O)c(C3OC(CO)C(O)C(O)C3O)c(O)c12 nan
CHEMBL1601394 60274 26 None - 1 Human 5.6 pEC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 432 3 7 10 0.1 O=c1cc(-c2ccc(O)cc2)oc2cc(O)c(C3OC(CO)C(O)C(O)C3O)c(O)c12 nan
1887804 119389 5 None -1 2 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 396 3 1 5 4.3 O=c1/c(=C\c2cccc(O)c2)sc2nc(-c3ccccc3)c(-c3ccccc3)n12 nan
CHEMBL3207339 119389 5 None -1 2 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 396 3 1 5 4.3 O=c1/c(=C\c2cccc(O)c2)sc2nc(-c3ccccc3)c(-c3ccccc3)n12 nan
CHEMBL3302244 119389 5 None -1 2 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 396 3 1 5 4.3 O=c1/c(=C\c2cccc(O)c2)sc2nc(-c3ccccc3)c(-c3ccccc3)n12 nan
87215 62771 2 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 400 4 1 1 6.7 Oc1ccc(-[n+]2c(-c3ccccc3)cc(-c3ccccc3)cc2-c2ccccc2)cc1 nan
CHEMBL1552591 62771 2 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 400 4 1 1 6.7 Oc1ccc(-[n+]2c(-c3ccccc3)cc(-c3ccccc3)cc2-c2ccccc2)cc1 nan
CHEMBL1624440 62771 2 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 400 4 1 1 6.7 Oc1ccc(-[n+]2c(-c3ccccc3)cc(-c3ccccc3)cc2-c2ccccc2)cc1 nan
42601134 66378 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 403 8 1 5 6.4 CCCCNc1c(-c2cccc(Sc3ccc(OC)cc3)c2)nc2ccccn12 nan
CHEMBL1719236 66378 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 403 8 1 5 6.4 CCCCNc1c(-c2cccc(Sc3ccc(OC)cc3)c2)nc2ccccn12 nan
CHEMBL3196955 66378 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 403 8 1 5 6.4 CCCCNc1c(-c2cccc(Sc3ccc(OC)cc3)c2)nc2ccccn12 nan
145975635 170565 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 826 13 8 9 3.3 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCC[C@](C)(N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4205887 170565 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 826 13 8 9 3.3 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCC[C@](C)(N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
118708057 120080 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 414 7 2 3 5.1 CC(C)C[C@H](NC(=O)Cn1ccc2ccc(-c3cccc4ccccc34)cc21)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL3315222 120080 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 414 7 2 3 5.1 CC(C)C[C@H](NC(=O)Cn1ccc2ccc(-c3cccc4ccccc34)cc21)C(=O)O 10.1016/j.bmcl.2014.06.033
145964771 170974 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4210760 170974 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
145970755 171559 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4218115 171559 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
2361995 56041 6 None -2 2 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 500 6 3 4 5.7 Cc1cc(F)ccc1S(=O)(=O)Nc1ccccc1C(=O)Nc1ccccc1-c1nc2ccccc2[nH]1 nan
CHEMBL1563110 56041 6 None -2 2 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 500 6 3 4 5.7 Cc1cc(F)ccc1S(=O)(=O)Nc1ccccc1C(=O)Nc1ccccc1-c1nc2ccccc2[nH]1 nan
2136878 57721 12 None -3 2 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 413 5 0 5 5.4 COc1cc2c3nnc(-c4ccc(F)cc4)c-3cn(Cc3ccccc3)c2cc1OC nan
CHEMBL1577981 57721 12 None -3 2 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 413 5 0 5 5.4 COc1cc2c3nnc(-c4ccc(F)cc4)c-3cn(Cc3ccccc3)c2cc1OC nan
2233014 45739 9 None -16 5 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 429 7 1 6 4.9 COc1ccc(CC(=O)Nc2cccc(-c3nnc(-c4cccc(C)c4)o3)c2)cc1OC nan
CHEMBL1467999 45739 9 None -16 5 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 429 7 1 6 4.9 COc1ccc(CC(=O)Nc2cccc(-c3nnc(-c4cccc(C)c4)o3)c2)cc1OC nan
49837912 111069 3 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at NTR1 (unknown origin) expressed in CHO cells assessed as Ca2+ mobilization by Fluo-4 NW dye-based fluorescence assayAgonist activity at NTR1 (unknown origin) expressed in CHO cells assessed as Ca2+ mobilization by Fluo-4 NW dye-based fluorescence assay
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
CHEMBL3099773 111069 3 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at NTR1 (unknown origin) expressed in CHO cells assessed as Ca2+ mobilization by Fluo-4 NW dye-based fluorescence assayAgonist activity at NTR1 (unknown origin) expressed in CHO cells assessed as Ca2+ mobilization by Fluo-4 NW dye-based fluorescence assay
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
49837912 111069 3 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2014.06.033
CHEMBL3099773 111069 3 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2014.06.033
145974670 171417 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 799 13 9 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4216311 171417 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 799 13 9 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
145974670 171417 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 799 13 9 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4216311 171417 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 799 13 9 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
653059 31784 2 None -3 2 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 407 4 1 5 4.7 Cc1sc(NC(=O)c2ccco2)nc1-c1ccc2c(c1)CC(C)N2C(=O)C1CC1 nan
CHEMBL1346595 31784 2 None -3 2 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 407 4 1 5 4.7 Cc1sc(NC(=O)c2ccco2)nc1-c1ccc2c(c1)CC(C)N2C(=O)C1CC1 nan
5360807 44000 39 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 590 13 4 7 5.8 CC[C@@H](C(=O)[C@@H](C)[C@@H](O)[C@H](C)CCc1ccc(C)c(O)c1C(=O)O)[C@H]1O[C@](CC)([C@H]2CC[C@](O)(CC)[C@H](C)O2)C[C@@H]1C nan
CHEMBL145347 44000 39 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 590 13 4 7 5.8 CC[C@@H](C(=O)[C@@H](C)[C@@H](O)[C@H](C)CCc1ccc(C)c(O)c1C(=O)O)[C@H]1O[C@](CC)([C@H]2CC[C@](O)(CC)[C@H](C)O2)C[C@@H]1C nan
CHEMBL1489769 44000 39 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 590 13 4 7 5.8 CC[C@@H](C(=O)[C@@H](C)[C@@H](O)[C@H](C)CCc1ccc(C)c(O)c1C(=O)O)[C@H]1O[C@](CC)([C@H]2CC[C@](O)(CC)[C@H](C)O2)C[C@@H]1C nan
800455 53964 18 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 327 3 2 4 5.1 Cc1ccc(-c2nc(Nc3cccc(O)c3)c3ccccc3n2)cc1 nan
CHEMBL1543298 53964 18 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 327 3 2 4 5.1 Cc1ccc(-c2nc(Nc3cccc(O)c3)c3ccccc3n2)cc1 nan
145964771 170974 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4210760 170974 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
1574 9585 20 None -26 6 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as increase in intracellular calcium level by FLIPR assay
ChEMBL None None None None 10.1016/j.bmcl.2008.09.075
1579 9585 20 None -26 6 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as increase in intracellular calcium level by FLIPR assay
ChEMBL None None None None 10.1016/j.bmcl.2008.09.075
25077406 9585 20 None -26 6 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as increase in intracellular calcium level by FLIPR assay
ChEMBL None None None None 10.1016/j.bmcl.2008.09.075
3830 9585 20 None -26 6 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as increase in intracellular calcium level by FLIPR assay
ChEMBL None None None None 10.1016/j.bmcl.2008.09.075
CHEMBL407196 9585 20 None -26 6 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as increase in intracellular calcium level by FLIPR assay
ChEMBL None None None None 10.1016/j.bmcl.2008.09.075
3237758 31986 11 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 390 3 1 5 4.7 O=C(Nc1ccc2oc(-c3ccccc3F)nc2c1)c1ccc2c(c1)OCCO2 nan
CHEMBL1348181 31986 11 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 390 3 1 5 4.7 O=C(Nc1ccc2oc(-c3ccccc3F)nc2c1)c1ccc2c(c1)OCCO2 nan
5894133 37803 2 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 314 6 0 6 2.9 COc1cc(C(=O)/C=C/c2cccnc2)c([N+](=O)[O-])cc1OC nan
CHEMBL1399212 37803 2 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 314 6 0 6 2.9 COc1cc(C(=O)/C=C/c2cccnc2)c([N+](=O)[O-])cc1OC nan
16196393 48273 0 None -1 2 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 575 9 3 7 3.6 CC(C)(C)OC(=O)N1CCC(NC(=O)c2[nH]cnc2C(=O)N[C@@H](Cc2ccccc2)C(=O)OCc2ccccc2)CC1 nan
CHEMBL1490916 48273 0 None -1 2 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 575 9 3 7 3.6 CC(C)(C)OC(=O)N1CCC(NC(=O)c2[nH]cnc2C(=O)N[C@@H](Cc2ccccc2)C(=O)OCc2ccccc2)CC1 nan
24891821 62461 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 433 9 1 6 6.4 CCCCNc1c(-c2ccc(OC)c(Sc3ccc(OC)cc3)c2)nc2ccccn12 nan
CHEMBL1444683 62461 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 433 9 1 6 6.4 CCCCNc1c(-c2ccc(OC)c(Sc3ccc(OC)cc3)c2)nc2ccccn12 nan
CHEMBL1621881 62461 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 433 9 1 6 6.4 CCCCNc1c(-c2ccc(OC)c(Sc3ccc(OC)cc3)c2)nc2ccccn12 nan
118708038 120073 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 415 7 2 4 4.5 CC(C)C[C@H](NC(=O)Cn1ccc2cc(-c3cncc4ccccc34)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL3315203 120073 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 415 7 2 4 4.5 CC(C)C[C@H](NC(=O)Cn1ccc2cc(-c3cncc4ccccc34)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
118708034 120069 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 414 7 2 3 5.1 CC(C)C[C@H](NC(=O)Cn1ccc2cc(-c3cccc4ccccc34)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL3315199 120069 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 414 7 2 3 5.1 CC(C)C[C@H](NC(=O)Cn1ccc2cc(-c3cccc4ccccc34)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
6552076 26502 1 None -9 3 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 487 4 0 7 4.5 COC(=O)C[C@]1(C(=O)OC)CN(C#N)N(c2ccc(Cl)cc2)C12c1ccccc1-c1ccccc12 nan
CHEMBL1301125 26502 1 None -9 3 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 487 4 0 7 4.5 COC(=O)C[C@]1(C(=O)OC)CN(C#N)N(c2ccc(Cl)cc2)C12c1ccccc1-c1ccccc12 nan
118708056 120079 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 415 7 2 4 4.5 CC(C)C[C@H](NC(=O)Cn1ccc2ccc(-c3cnc4ccccc4c3)cc21)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL3315221 120079 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 415 7 2 4 4.5 CC(C)C[C@H](NC(=O)Cn1ccc2ccc(-c3cnc4ccccc4c3)cc21)C(=O)O 10.1016/j.bmcl.2014.06.033
3816756 61876 8 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 373 5 0 3 3.7 O=C(c1ccc(Br)cc1)C(CN1CCOCC1)c1ccccc1 nan
CHEMBL1372112 61876 8 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 373 5 0 3 3.7 O=C(c1ccc(Br)cc1)C(CN1CCOCC1)c1ccccc1 nan
CHEMBL1616855 61876 8 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 373 5 0 3 3.7 O=C(c1ccc(Br)cc1)C(CN1CCOCC1)c1ccccc1 nan
7634362 29031 8 None - 1 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 393 7 3 7 1.8 CCOC(=O)c1c(C)[nH]c(C(=O)OCC(=O)Nc2sccc2C(N)=O)c1C nan
CHEMBL1323442 29031 8 None - 1 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 393 7 3 7 1.8 CCOC(=O)c1c(C)[nH]c(C(=O)OCC(=O)Nc2sccc2C(N)=O)c1C nan
1181160 66783 16 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 370 3 0 4 4.9 CC1(C)CC(=O)C(=Cc2cn(-c3ccccc3)nc2-c2ccccc2)C(=O)C1 nan
CHEMBL1734949 66783 16 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 370 3 0 4 4.9 CC1(C)CC(=O)C(=Cc2cn(-c3ccccc3)nc2-c2ccccc2)C(=O)C1 nan
145966676 171027 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 784 13 9 10 0.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4211344 171027 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 784 13 9 10 0.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
1345509 52305 24 None -2 2 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 404 3 0 4 5.5 CC1(C)CC(=O)C(=Cc2cn(-c3ccccc3)nc2-c2ccc(Cl)cc2)C(=O)C1 nan
CHEMBL1528569 52305 24 None -2 2 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 404 3 0 4 5.5 CC1(C)CC(=O)C(=Cc2cn(-c3ccccc3)nc2-c2ccc(Cl)cc2)C(=O)C1 nan
2136899 27436 12 None - 1 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 431 5 0 5 5.5 COc1cc2c3nnc(-c4ccc(F)cc4)c-3cn(Cc3cccc(F)c3)c2cc1OC nan
CHEMBL1308657 27436 12 None - 1 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 431 5 0 5 5.5 COc1cc2c3nnc(-c4ccc(F)cc4)c-3cn(Cc3cccc(F)c3)c2cc1OC nan
1388911 60095 11 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 400 5 0 7 3.1 COc1ccc(-n2ncc3c(N4CCN(Cc5ccccc5)CC4)ncnc32)cc1 nan
CHEMBL1599740 60095 11 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 400 5 0 7 3.1 COc1ccc(-n2ncc3c(N4CCN(Cc5ccccc5)CC4)ncnc32)cc1 nan
145975635 170565 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 826 13 8 9 3.3 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCC[C@](C)(N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4205887 170565 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 826 13 8 9 3.3 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCC[C@](C)(N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
1400670 31522 8 None -3 2 Human 4.4 pEC50 = 4.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 392 3 1 6 4.3 Clc1ccc(C2=Nn3c(nnc3-c3cc(-c4ccccc4)[nH]n3)SC2)cc1 nan
CHEMBL1344250 31522 8 None -3 2 Human 4.4 pEC50 = 4.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 392 3 1 6 4.3 Clc1ccc(C2=Nn3c(nnc3-c3cc(-c4ccccc4)[nH]n3)SC2)cc1 nan
1224762 48198 10 None - 1 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 363 4 1 7 3.4 Cn1cc([N+](=O)[O-])c(C(=O)Nc2nc(-c3ccc(Cl)cc3)cs2)n1 nan
CHEMBL1490404 48198 10 None - 1 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 363 4 1 7 3.4 Cn1cc([N+](=O)[O-])c(C(=O)Nc2nc(-c3ccc(Cl)cc3)cs2)n1 nan
3799752 33103 8 None -3 3 Human 4.4 pEC50 = 4.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 397 6 2 6 2.4 COc1ccc(OC)c(N/C=C2/C(=O)NC(=S)N(Cc3ccccc3)C2=O)c1 nan
CHEMBL1358861 33103 8 None -3 3 Human 4.4 pEC50 = 4.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 397 6 2 6 2.4 COc1ccc(OC)c(N/C=C2/C(=O)NC(=S)N(Cc3ccccc3)C2=O)c1 nan
1040545 61421 6 None 2 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 353 10 0 8 1.8 CCOC(=O)COc1ccc(/C=C/[N+](=O)[O-])c(OCC(=O)OCC)c1 nan
CHEMBL1611170 61421 6 None 2 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 353 10 0 8 1.8 CCOC(=O)COc1ccc(/C=C/[N+](=O)[O-])c(OCC(=O)OCC)c1 nan
145972052 171297 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 841 13 9 10 2.2 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4214816 171297 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 841 13 9 10 2.2 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
678138 60133 19 None 6 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 303 4 2 4 1.4 CCN(CC)c1ccc(C=C2C(=O)NC(=S)NC2=O)cc1 nan
CHEMBL1600146 60133 19 None 6 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 303 4 2 4 1.4 CCN(CC)c1ccc(C=C2C(=O)NC(=S)NC2=O)cc1 nan
1325215 46054 6 None -3 2 Human 4.4 pEC50 = 4.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 364 5 1 3 3.1 O=C1NC(=O)N(CCc2ccc(F)cc2)C(=O)/C1=C/C=C/c1ccccc1 nan
CHEMBL1470682 46054 6 None -3 2 Human 4.4 pEC50 = 4.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 364 5 1 3 3.1 O=C1NC(=O)N(CCc2ccc(F)cc2)C(=O)/C1=C/C=C/c1ccccc1 nan
145974670 171417 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 799 13 9 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4216311 171417 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 799 13 9 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
1257866 45785 10 None - 1 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 419 5 2 7 2.2 O=C1NC(=O)C(=Cc2cn(CCOc3ccc4c(c3)OCO4)c3ccccc23)C(=O)N1 nan
CHEMBL1468368 45785 10 None - 1 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 419 5 2 7 2.2 O=C1NC(=O)C(=Cc2cn(CCOc3ccc4c(c3)OCO4)c3ccccc23)C(=O)N1 nan
2547793 53654 5 None - 1 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 483 7 0 6 5.1 CCc1cccc(CC)c1-n1c(SCC(=O)N2CCc3ccccc3C2)nnc1-c1cccnc1 nan
CHEMBL1540679 53654 5 None - 1 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 483 7 0 6 5.1 CCc1cccc(CC)c1-n1c(SCC(=O)N2CCc3ccccc3C2)nnc1-c1cccnc1 nan
2060089 26349 11 None - 1 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 206 3 0 3 2.4 C/C(=C\c1ccc(N(C)C)cc1)[N+](=O)[O-] nan
CHEMBL1299997 26349 11 None - 1 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 206 3 0 3 2.4 C/C(=C\c1ccc(N(C)C)cc1)[N+](=O)[O-] nan
145966776 171215 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 782 13 7 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCCC(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4213725 171215 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 782 13 7 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCCC(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
118708048 120078 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 449 7 2 4 4.7 O=C(Cn1ccc2cc(-c3cnc4ccccc4c3)ccc21)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL3315213 120078 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 449 7 2 4 4.7 O=C(Cn1ccc2cc(-c3cnc4ccccc4c3)ccc21)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL508338 195745 0 None -47 15 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL None None None None nan
118708037 120072 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 415 7 2 4 4.5 CC(C)C[C@H](NC(=O)Cn1ccc2cc(-c3cccc4cnccc34)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL3315202 120072 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 415 7 2 4 4.5 CC(C)C[C@H](NC(=O)Cn1ccc2cc(-c3cccc4cnccc34)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
155569737 183414 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysisAgonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4457798 183414 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysisAgonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4597941 183414 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysisAgonist activity at human neurotensin receptor 1 in HT-29 cells assessed as intracellular calcium mobilization by Fura-2 dye based spectrofluorimetry analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
145972052 171297 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 841 13 9 10 2.2 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4214816 171297 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 841 13 9 10 2.2 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
6001017 54330 4 None 1 2 Human 5.3 pEC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 334 3 1 5 3.5 CC1=NNC(=O)/C1=C\c1cn(-c2ccccc2)nc1-c1cccs1 nan
CHEMBL1546134 54330 4 None 1 2 Human 5.3 pEC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 334 3 1 5 3.5 CC1=NNC(=O)/C1=C\c1cn(-c2ccccc2)nc1-c1cccs1 nan
118708044 120077 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 439 7 2 6 4.3 CC(C)C[C@H](NC(=O)Cn1ccc2cc(-c3cnc4ccccc4c3)ccc21)c1nn[nH]n1 10.1016/j.bmcl.2014.06.033
CHEMBL3315209 120077 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 439 7 2 6 4.3 CC(C)C[C@H](NC(=O)Cn1ccc2cc(-c3cnc4ccccc4c3)ccc21)c1nn[nH]n1 10.1016/j.bmcl.2014.06.033
145970755 171559 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4218115 171559 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
145977513 170345 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 827 13 9 10 1.8 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4203162 170345 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 827 13 9 10 1.8 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
1489267 201452 15 None 2 2 Human 5.3 pEC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 495 8 1 7 5.8 COc1ccc(Cn2c(SCc3ccc(C)cc3)nc3cc(OC)c(OC)cc3c2=N)cc1Cl nan
CHEMBL532160 201452 15 None 2 2 Human 5.3 pEC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 495 8 1 7 5.8 COc1ccc(Cn2c(SCc3ccc(C)cc3)nc3cc(OC)c(OC)cc3c2=N)cc1Cl nan
145975635 170565 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 826 13 8 9 3.3 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCC[C@](C)(N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4205887 170565 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 826 13 8 9 3.3 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCC[C@](C)(N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
16745378 53343 0 None 2 2 Human 5.3 pEC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 462 10 3 5 3.8 CC(C)C[C@H](NC(=O)c1[nH]cnc1C(=O)N[C@@H](C)c1ccccc1)C(=O)OCc1ccccc1 nan
CHEMBL1538066 53343 0 None 2 2 Human 5.3 pEC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 462 10 3 5 3.8 CC(C)C[C@H](NC(=O)c1[nH]cnc1C(=O)N[C@@H](C)c1ccccc1)C(=O)OCc1ccccc1 nan
145966676 171027 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 784 13 9 10 0.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4211344 171027 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 784 13 9 10 0.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
118708036 120071 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 458 8 3 5 4.1 CC(C)C[C@H](NC(=O)Cn1ccc2cc(NC(=O)c3ccnc4ccccc34)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL3315201 120071 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 458 8 3 5 4.1 CC(C)C[C@H](NC(=O)Cn1ccc2cc(NC(=O)c3ccnc4ccccc34)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
145976418 170665 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 798 13 8 9 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCCCC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4206981 170665 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 798 13 8 9 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCCCC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
44572618 195760 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL 845 24 11 10 0.3 CC(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
CHEMBL508507 195760 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL 845 24 11 10 0.3 CC(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
2136935 59049 13 None 1 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 443 6 0 6 5.4 COc1ccc(Cn2cc3c(-c4ccc(F)cc4)nnc-3c3cc(OC)c(OC)cc32)cc1 nan
CHEMBL1589062 59049 13 None 1 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 443 6 0 6 5.4 COc1ccc(Cn2cc3c(-c4ccc(F)cc4)nnc-3c3cc(OC)c(OC)cc32)cc1 nan
2136882 26759 8 None -7 3 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 413 5 0 5 5.4 COc1cc2c3nnc(-c4ccccc4)c-3cn(Cc3ccccc3F)c2cc1OC nan
CHEMBL1303193 26759 8 None -7 3 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 413 5 0 5 5.4 COc1cc2c3nnc(-c4ccccc4)c-3cn(Cc3ccccc3F)c2cc1OC nan
12005285 59838 6 None -3 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 402 8 1 9 4.0 CC(=O)OCCCNc1cc(Sc2ccc(C)cc2)c2nonc2c1[N+](=O)[O-] nan
CHEMBL1597454 59838 6 None -3 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 402 8 1 9 4.0 CC(=O)OCCCNc1cc(Sc2ccc(C)cc2)c2nonc2c1[N+](=O)[O-] nan
1274511 54470 9 None 2 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 401 8 0 8 2.9 COC(=O)C(=Cc1ccc(OCc2ccc([N+](=O)[O-])cc2)c(OC)c1)C(=O)OC nan
CHEMBL1547420 54470 9 None 2 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 401 8 0 8 2.9 COC(=O)C(=Cc1ccc(OCc2ccc([N+](=O)[O-])cc2)c(OC)c1)C(=O)OC nan
44572617 195576 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL 803 23 11 10 0.2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@H](N)CCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL505906 195576 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL 803 23 11 10 0.2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@H](N)CCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
44572621 195032 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL 817 23 11 10 0.5 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@](C)(N)CCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL499673 195032 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL 817 23 11 10 0.5 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@](C)(N)CCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
1254872 27912 12 None 3 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 449 4 1 5 4.9 O=C(Nc1ccc(N2CCN(C(=O)c3ccco3)CC2)c(Cl)c1)c1cc2ccccc2o1 nan
CHEMBL1312502 27912 12 None 3 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 449 4 1 5 4.9 O=C(Nc1ccc(N2CCN(C(=O)c3ccco3)CC2)c(Cl)c1)c1cc2ccccc2o1 nan
1230852 43116 3 None - 1 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 434 6 0 7 4.3 COc1cc2nc(C3CCC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC nan
CHEMBL1446377 43116 3 None - 1 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 434 6 0 7 4.3 COc1cc2nc(C3CCC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC nan
1077240 29589 11 None 2 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 436 5 0 8 4.9 Cc1cc(C)n(-c2nc(N(c3ccccc3)c3ccccc3)nc(-n3nc(C)cc3C)n2)n1 nan
CHEMBL1328169 29589 11 None 2 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 436 5 0 8 4.9 Cc1cc(C)n(-c2nc(N(c3ccccc3)c3ccccc3)nc(-n3nc(C)cc3C)n2)n1 nan
2199612 58717 8 None - 1 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 361 2 1 3 4.3 Cc1cc(C)c2c(c1)/C(=C/C(=O)c1ccc(Br)s1)C(=O)N2 nan
CHEMBL1586252 58717 8 None - 1 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 361 2 1 3 4.3 Cc1cc(C)c2c(c1)/C(=C/C(=O)c1ccc(Br)s1)C(=O)N2 nan
145967420 171059 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 997 16 8 13 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCN(S(=O)(=O)c2ccccc2[N+](=O)[O-])CCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4211866 171059 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 997 16 8 13 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCN(S(=O)(=O)c2ccccc2[N+](=O)[O-])CCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
6211977 59489 3 None 1 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 370 4 2 7 3.8 CCOC(=O)/C(=C\c1cccc(O)c1)c1nc(O)c2c(C)c(C)sc2n1 nan
CHEMBL1594369 59489 3 None 1 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 370 4 2 7 3.8 CCOC(=O)/C(=C\c1cccc(O)c1)c1nc(O)c2c(C)c(C)sc2n1 nan
145970755 171559 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4218115 171559 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assayAgonist activity at Galpha13-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galpha13 activation after 5 mins by BRET assay
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
135548673 79670 8 None 1 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 402 6 2 7 3.2 CN(C)S(=O)(=O)c1ccc(-c2csc(N/N=C/c3ccc(O)cc3)n2)cc1 nan
CHEMBL2003819 79670 8 None 1 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 402 6 2 7 3.2 CN(C)S(=O)(=O)c1ccc(-c2csc(N/N=C/c3ccc(O)cc3)n2)cc1 nan
45490651 120064 11 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 288 6 2 3 2.3 CC(C)C[C@H](NC(=O)Cn1ccc2ccccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL3315194 120064 11 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 288 6 2 3 2.3 CC(C)C[C@H](NC(=O)Cn1ccc2ccccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
5334257 115675 9 None - 1 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 511 11 1 8 2.6 COC(=O)COc1ccc(/C=N/NC(=O)CN(c2ccccc2OC)S(=O)(=O)c2ccccc2)cc1 nan
CHEMBL3210863 115675 9 None - 1 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 511 11 1 8 2.6 COC(=O)COc1ccc(/C=N/NC(=O)CN(c2ccccc2OC)S(=O)(=O)c2ccccc2)cc1 nan
1919229 205841 9 None -2 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 314 8 1 2 5.1 CCCCCCCCCn1c2c(c(=N)c3c1CCC3)CCCC2 nan
CHEMBL1613675 205841 9 None -2 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 314 8 1 2 5.1 CCCCCCCCCn1c2c(c(=N)c3c1CCC3)CCCC2 nan
CHEMBL586602 205841 9 None -2 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 314 8 1 2 5.1 CCCCCCCCCn1c2c(c(=N)c3c1CCC3)CCCC2 nan
5919900 54828 16 None -2 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 273 2 0 3 3.6 N#CC1=C(c2ccccc2)/C(=C/c2ccccc2)OC1=O nan
CHEMBL1550591 54828 16 None -2 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 273 2 0 3 3.6 N#CC1=C(c2ccccc2)/C(=C/c2ccccc2)OC1=O nan
8259799 47349 3 None 1 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 406 4 2 4 5.8 O=C(Nc1ccc(Cl)cc1)/C(=C/c1cccc(O)c1)c1nc2ccccc2s1 nan
CHEMBL1483562 47349 3 None 1 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 406 4 2 4 5.8 O=C(Nc1ccc(Cl)cc1)/C(=C/c1cccc(O)c1)c1nc2ccccc2s1 nan
44157038 195718 16 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1cc(C(=O)N[C@@H](CC(C)C)C(=O)O)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2009.01.024
CHEMBL508044 195718 16 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1cc(C(=O)N[C@@H](CC(C)C)C(=O)O)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2009.01.024
145976898 170611 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 841 29 9 10 2.2 C=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)c(CC=C)c1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b00175
CHEMBL4206391 170611 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 841 29 9 10 2.2 C=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)c(CC=C)c1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b00175
44572620 180637 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL 828 24 10 10 1.5 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@H](CCCCN)N=[N+]=[N-])C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL453924 180637 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL 828 24 10 10 1.5 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@H](CCCCN)N=[N+]=[N-])C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL501575 220918 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@](C)(N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
44572619 178997 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL 817 24 11 10 0.4 CN[C@@H](CCCCN)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
CHEMBL447400 178997 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL 817 24 11 10 0.4 CN[C@@H](CCCCN)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
6532771 78543 1 None - 1 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 496 8 1 8 1.5 CCOC(=O)/C=c1\s/c(=C\c2ccc3cc(OC)ccc3c2)c(=O)n1CC(=O)NCC1CCCO1 nan
CHEMBL1966869 78543 1 None - 1 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 496 8 1 8 1.5 CCOC(=O)/C=c1\s/c(=C\c2ccc3cc(OC)ccc3c2)c(=O)n1CC(=O)NCC1CCCO1 nan
4081288 42213 5 None - 1 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 335 5 1 7 3.8 CC(C)c1ccc(Nc2nnc(SC3CCOC3=O)s2)cc1 nan
CHEMBL1438069 42213 5 None - 1 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 335 5 1 7 3.8 CC(C)c1ccc(Nc2nnc(SC3CCOC3=O)s2)cc1 nan
145967420 171059 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 997 16 8 13 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCN(S(=O)(=O)c2ccccc2[N+](=O)[O-])CCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4211866 171059 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assayAgonist activity at Galphaq-Rluc2/Gbeta1/GFP10-Ggamma1 fused human NTS1 expressed in CHO-K1 cell membranes assessed as Galphaq activation after 5 mins by BRET assay
ChEMBL 997 16 8 13 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCN(S(=O)(=O)c2ccccc2[N+](=O)[O-])CCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
118708058 120081 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 415 7 2 4 4.5 CC(C)C[C@H](NC(=O)Cn1ccc2ccc(-c3cncc4ccccc34)cc21)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL3315223 120081 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 415 7 2 4 4.5 CC(C)C[C@H](NC(=O)Cn1ccc2ccc(-c3cncc4ccccc34)cc21)C(=O)O 10.1016/j.bmcl.2014.06.033
5193534 62967 1 None - 1 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 398 4 0 0 7.3 Cc1ccc(-c2cc(-c3ccccc3)cc(-c3ccccc3)[n+]2-c2ccccc2)cc1 nan
CHEMBL1611686 62967 1 None - 1 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 398 4 0 0 7.3 Cc1ccc(-c2cc(-c3ccccc3)cc(-c3ccccc3)[n+]2-c2ccccc2)cc1 nan
CHEMBL1626297 62967 1 None - 1 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 398 4 0 0 7.3 Cc1ccc(-c2cc(-c3ccccc3)cc(-c3ccccc3)[n+]2-c2ccccc2)cc1 nan
5733602 59585 7 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 321 2 0 4 4.6 CC1=NOC(=O)/C1=C\c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
CHEMBL1595121 59585 7 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 321 2 0 4 4.6 CC1=NOC(=O)/C1=C\c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
1547875 44050 7 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 369 4 3 5 4.1 Cc1ccc(C(=O)Nc2nnc(N=C(S)Nc3ccccc3)s2)cc1 nan
CHEMBL1453900 44050 7 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 369 4 3 5 4.1 Cc1ccc(C(=O)Nc2nnc(N=C(S)Nc3ccccc3)s2)cc1 nan
11957208 62974 3 None -10 4 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 336 3 1 3 3.9 COC(=O)c1ccc2c(c1)C(C)(C)C(/C=C/c1ccc(O)cc1)=[N+]2C nan
CHEMBL1340713 62974 3 None -10 4 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 336 3 1 3 3.9 COC(=O)c1ccc2c(c1)C(C)(C)C(/C=C/c1ccc(O)cc1)=[N+]2C nan
CHEMBL1626334 62974 3 None -10 4 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 336 3 1 3 3.9 COC(=O)c1ccc2c(c1)C(C)(C)C(/C=C/c1ccc(O)cc1)=[N+]2C nan
CHEMBL500734 220902 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL None None None CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
118708039 120074 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 430 8 3 5 4.5 CC(C)C[C@H](NC(=O)Cn1ccc2cc(Nc3ccc4cnccc4c3)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL3315204 120074 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 430 8 3 5 4.5 CC(C)C[C@H](NC(=O)Cn1ccc2cc(Nc3ccc4cnccc4c3)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
44572627 195064 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL 796 22 10 8 1.6 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CCCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL500173 195064 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assayAgonist activity at NTR1 in human HT-29 cells assessed as increase in intracellular calcium concentration by FLIPR assay
ChEMBL 796 22 10 8 1.6 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CCCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/jm801072v
1077243 44937 7 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 374 4 1 8 3.5 Cc1cc(C)n(-c2nc(Nc3ccccc3C)nc(-n3nc(C)cc3C)n2)n1 nan
CHEMBL1461496 44937 7 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 374 4 1 8 3.5 Cc1cc(C)n(-c2nc(Nc3ccccc3C)nc(-n3nc(C)cc3C)n2)n1 nan
1619531 36613 9 None -1 3 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 374 4 0 6 4.5 Cc1ccc(-c2ccc(/C=C3\C(=O)ON=C3c3ccccc3)o2)c([N+](=O)[O-])c1 nan
CHEMBL1387563 36613 9 None -1 3 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 374 4 0 6 4.5 Cc1ccc(-c2ccc(/C=C3\C(=O)ON=C3c3ccccc3)o2)c([N+](=O)[O-])c1 nan
1504002 28821 4 None - 1 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 221 1 1 2 2.5 Nc1ccccc1C#CC(=O)c1ccccc1 nan
CHEMBL1321527 28821 4 None - 1 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 221 1 1 2 2.5 Nc1ccccc1C#CC(=O)c1ccccc1 nan
4602677 36318 12 None - 1 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 309 3 1 5 3.4 CSc1nnc(NC(=O)C23CC4CC(CC(C4)C2)C3)s1 nan
CHEMBL1385214 36318 12 None - 1 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 309 3 1 5 3.4 CSc1nnc(NC(=O)C23CC4CC(CC(C4)C2)C3)s1 nan
787747 34342 10 None -1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 299 2 1 4 3.4 O=C1ON=C(c2ccc(Cl)cc2)/C1=C/c1ccc(O)cc1 nan
CHEMBL1369296 34342 10 None -1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 299 2 1 4 3.4 O=C1ON=C(c2ccc(Cl)cc2)/C1=C/c1ccc(O)cc1 nan
6122140 54868 4 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 358 4 1 2 5.6 O=C(/C(=C/c1cccc(Cl)c1)c1nc2ccccc2[nH]1)c1ccccc1 nan
CHEMBL1550862 54868 4 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 358 4 1 2 5.6 O=C(/C(=C/c1cccc(Cl)c1)c1nc2ccccc2[nH]1)c1ccccc1 nan
9607375 79439 8 None -1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 376 6 1 7 3.1 CN(C)S(=O)(=O)c1ccc(-c2csc(N/N=C/c3ccco3)n2)cc1 nan
CHEMBL1995726 79439 8 None -1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 376 6 1 7 3.1 CN(C)S(=O)(=O)c1ccc(-c2csc(N/N=C/c3ccco3)n2)cc1 nan
2971598 61104 12 None - 1 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 349 3 3 3 3.8 O=C(CC1Nc2ccccc2NC1=O)Nc1cc(Cl)cc(Cl)c1 nan
CHEMBL1608453 61104 12 None - 1 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 349 3 3 3 3.8 O=C(CC1Nc2ccccc2NC1=O)Nc1cc(Cl)cc(Cl)c1 nan
2538553 49598 6 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 451 5 0 8 5.1 Cc1ccc(-c2csc3ncnc(Sc4nnc(CN5CCCCCC5=O)o4)c23)cc1 nan
CHEMBL1502512 49598 6 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 451 5 0 8 5.1 Cc1ccc(-c2csc3ncnc(Sc4nnc(CN5CCCCCC5=O)o4)c23)cc1 nan
3092513 62874 3 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 449 7 0 4 5.4 Cc1cccc(OCc2n(C)c3ccccc3[n+]2CC(=O)OC2CC(C)CCC2C(C)C)c1 nan
CHEMBL1586169 62874 3 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 449 7 0 4 5.4 Cc1cccc(OCc2n(C)c3ccccc3[n+]2CC(=O)OC2CC(C)CCC2C(C)C)c1 nan
CHEMBL1625353 62874 3 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 449 7 0 4 5.4 Cc1cccc(OCc2n(C)c3ccccc3[n+]2CC(=O)OC2CC(C)CCC2C(C)C)c1 nan
4576185 48607 13 None -8 4 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 413 7 1 9 3.3 COc1ccc(Oc2cc(NC(=O)c3nn(C)cc3[N+](=O)[O-])cc([N+](=O)[O-])c2)cc1 nan
CHEMBL1493442 48607 13 None -8 4 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 413 7 1 9 3.3 COc1ccc(Oc2cc(NC(=O)c3nn(C)cc3[N+](=O)[O-])cc([N+](=O)[O-])c2)cc1 nan
16114081 184167 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 494 9 3 6 3.6 CC(C)C[C@H](NC(=O)Cn1ccc2cc(NS(=O)(=O)c3cccc4cccnc34)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL463811 184167 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 494 9 3 6 3.6 CC(C)C[C@H](NC(=O)Cn1ccc2cc(NS(=O)(=O)c3cccc4cccnc34)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
145976898 170611 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 841 29 9 10 2.2 C=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)c(CC=C)c1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b00175
CHEMBL4206391 170611 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 841 29 9 10 2.2 C=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)c(CC=C)c1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b00175
5662106 29286 8 None -1 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 257 4 0 4 2.8 CN(C)c1ccc(-n2cccc2/C=C/[N+](=O)[O-])cc1 nan
CHEMBL1325640 29286 8 None -1 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 257 4 0 4 2.8 CN(C)c1ccc(-n2cccc2/C=C/[N+](=O)[O-])cc1 nan
2281759 29839 8 None 1 2 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 405 3 1 4 4.1 Cc1cccc(N2C(=O)NC(=O)/C(=C\c3cccn3-c3ccc(Cl)cc3)C2=O)c1 nan
CHEMBL1330390 29839 8 None 1 2 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 405 3 1 4 4.1 Cc1cccc(N2C(=O)NC(=O)/C(=C\c3cccn3-c3ccc(Cl)cc3)C2=O)c1 nan
4353821 60105 10 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 409 7 1 6 3.1 CCCCCn1c(N2CCC(Cc3ccccc3)CC2)nc2c1c(=O)[nH]c(=O)n2C nan
CHEMBL1599800 60105 10 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 409 7 1 6 3.1 CCCCCn1c(N2CCC(Cc3ccccc3)CC2)nc2c1c(=O)[nH]c(=O)n2C nan
145967420 171059 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 997 16 8 13 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCN(S(=O)(=O)c2ccccc2[N+](=O)[O-])CCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4211866 171059 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 997 16 8 13 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCN(S(=O)(=O)c2ccccc2[N+](=O)[O-])CCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
3350604 45345 5 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 434 9 1 7 2.3 CC(CCc1ccccc1)NC(=O)COC(=O)c1ccc(S(C)(=O)=O)c([N+](=O)[O-])c1 nan
CHEMBL1464832 45345 5 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 434 9 1 7 2.3 CC(CCc1ccccc1)NC(=O)COC(=O)c1ccc(S(C)(=O)=O)c([N+](=O)[O-])c1 nan
118708035 120070 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 493 9 3 5 4.2 CC(C)C[C@H](NC(=O)Cn1ccc2cc(NS(=O)(=O)c3cccc4ccccc34)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL3315200 120070 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 493 9 3 5 4.2 CC(C)C[C@H](NC(=O)Cn1ccc2cc(NS(=O)(=O)c3cccc4ccccc34)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
2848959 29628 20 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 265 2 0 4 3.1 COc1cc2c(cc1OC)C(SC)=NC(C)(C)C2 nan
CHEMBL1328520 29628 20 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 265 2 0 4 3.1 COc1cc2c(cc1OC)C(SC)=NC(C)(C)C2 nan
5346304 47444 10 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 313 6 0 5 3.5 COc1cccc(/C=C/C(=O)c2cccc([N+](=O)[O-])c2)c1OC nan
CHEMBL1484272 47444 10 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 313 6 0 5 3.5 COc1cccc(/C=C/C(=O)c2cccc([N+](=O)[O-])c2)c1OC nan
118708032 120067 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 364 7 2 3 3.9 CC(C)C[C@H](NC(=O)Cn1ccc2cc(-c3ccccc3)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL3315197 120067 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 364 7 2 3 3.9 CC(C)C[C@H](NC(=O)Cn1ccc2cc(-c3ccccc3)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
887759 58402 8 None 1 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 243 4 0 3 3.5 CCOc1ccc(/C=C/[N+](=O)[O-])c2ccccc12 nan
CHEMBL1583665 58402 8 None 1 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 243 4 0 3 3.5 CCOc1ccc(/C=C/[N+](=O)[O-])c2ccccc12 nan
25110544 48171 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 377 3 3 6 4.9 N#Cc1ccc(Nc2nc(-c3ccc(O)cc3O)cs2)cc1C(F)(F)F nan
CHEMBL1490267 48171 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 377 3 3 6 4.9 N#Cc1ccc(Nc2nc(-c3ccc(O)cc3O)cs2)cc1C(F)(F)F nan
145976418 170665 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 798 13 8 9 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCCCC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4206981 170665 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin1-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin1 recruitment after 20 mins by BRET assay
ChEMBL 798 13 8 9 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCCCC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
145976418 170665 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 798 13 8 9 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCCCC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4206981 170665 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assayAgonist activity at GFP10/beta-arrestin2-Rluc2 fused human NTS1 expressed in CHO-K1 cell membranes assessed as beta-arrestin2 recruitment after 20 mins by BRET assay
ChEMBL 798 13 8 9 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCCCC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
1547881 57619 2 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 399 6 3 6 4.2 CCOc1ccc(C(=O)Nc2nnc(N=C(S)Nc3ccccc3)s2)cc1 nan
CHEMBL1577072 57619 2 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 399 6 3 6 4.2 CCOc1ccc(C(=O)Nc2nnc(N=C(S)Nc3ccccc3)s2)cc1 nan
4112227 40257 10 None -2 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 392 3 0 7 4.0 Fc1ccc(-n2nnnc2-c2cnc(-c3cccs3)nc2C(F)(F)F)cc1 nan
CHEMBL1420175 40257 10 None -2 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 392 3 0 7 4.0 Fc1ccc(-n2nnnc2-c2cnc(-c3cccs3)nc2C(F)(F)F)cc1 nan
4898241 44940 5 None -1 2 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 527 3 2 4 5.4 CCc1ccc2c(c1)C1(C(=O)N2)N2CCCC2C(C(=O)c2ccc3ccccc3c2)C12C(=O)Nc1ccccc12 nan
CHEMBL1461508 44940 5 None -1 2 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 527 3 2 4 5.4 CCc1ccc2c(c1)C1(C(=O)N2)N2CCCC2C(C(=O)c2ccc3ccccc3c2)C12C(=O)Nc1ccccc12 nan
661231 38737 10 None 2 2 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 384 3 0 6 3.8 Cc1ccc(-n2ncc3c(N4CCN(c5ccccc5)CC4)ncnc32)c(C)c1 nan
CHEMBL1407659 38737 10 None 2 2 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 384 3 0 6 3.8 Cc1ccc(-n2ncc3c(N4CCN(c5ccccc5)CC4)ncnc32)c(C)c1 nan
44157039 183808 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1cc(C(=O)N[C@H](CC(C)C)C(=O)O)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2009.01.024
CHEMBL463227 183808 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assayAgonist activity at NTR1 expressed in CHOK1 cells by calcium mobilization assay
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1cc(C(=O)N[C@H](CC(C)C)C(=O)O)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2009.01.024
2295300 43192 10 None -7 5 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 356 8 1 5 3.7 CCOc1cc(/C=C\[N+](=O)[O-])ccc1OCC(=O)Nc1ccccc1C nan
CHEMBL1446971 43192 10 None -7 5 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]PUBCHEM_BIOASSAY: Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493036, AID493055]
ChEMBL 356 8 1 5 3.7 CCOc1cc(/C=C\[N+](=O)[O-])ccc1OCC(=O)Nc1ccccc1C nan
56723766 120065 10 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 366 6 2 3 3.0 CC(C)C[C@H](NC(=O)Cn1ccc2cc(Br)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
CHEMBL3315195 120065 10 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAgonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as potentiation of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 366 6 2 3 3.0 CC(C)C[C@H](NC(=O)Cn1ccc2cc(Br)ccc21)C(=O)O 10.1016/j.bmcl.2014.06.033
44581036 194679 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins before with SR-48692 by FLIPR assayAntagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins before with SR-48692 by FLIPR assay
ChEMBL 494 9 3 6 3.6 CC(C)C[C@@H](NC(=O)Cn1ccc2cc(NS(=O)(=O)c3cccc4cccnc34)ccc21)C(=O)O 10.1016/j.bmcl.2008.09.075
CHEMBL496585 194679 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins before with SR-48692 by FLIPR assayAntagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins before with SR-48692 by FLIPR assay
ChEMBL 494 9 3 6 3.6 CC(C)C[C@@H](NC(=O)Cn1ccc2cc(NS(=O)(=O)c3cccc4cccnc34)ccc21)C(=O)O 10.1016/j.bmcl.2008.09.075
4308 107870 53 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins before with SR-48692 by FLIPR assayAntagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins before with SR-48692 by FLIPR assay
ChEMBL 353 6 2 3 4.0 CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O 10.1016/j.bmcl.2008.09.075
CHEMBL294989 107870 53 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins before with SR-48692 by FLIPR assayAntagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins before with SR-48692 by FLIPR assay
ChEMBL 353 6 2 3 4.0 CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O 10.1016/j.bmcl.2008.09.075
1580 10437 46 None 1 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as inhibition of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAntagonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as inhibition of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2014.06.033
5311451 10437 46 None 1 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as inhibition of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAntagonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as inhibition of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2014.06.033
CHEMBL3040381 10437 46 None 1 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as inhibition of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAntagonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as inhibition of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2014.06.033
1574 9585 20 None -26 6 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins before with SR-48692 by FLIPR assayAntagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins before with SR-48692 by FLIPR assay
ChEMBL None None None None 10.1016/j.bmcl.2008.09.075
1579 9585 20 None -26 6 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins before with SR-48692 by FLIPR assayAntagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins before with SR-48692 by FLIPR assay
ChEMBL None None None None 10.1016/j.bmcl.2008.09.075
25077406 9585 20 None -26 6 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins before with SR-48692 by FLIPR assayAntagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins before with SR-48692 by FLIPR assay
ChEMBL None None None None 10.1016/j.bmcl.2008.09.075
3830 9585 20 None -26 6 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins before with SR-48692 by FLIPR assayAntagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins before with SR-48692 by FLIPR assay
ChEMBL None None None None 10.1016/j.bmcl.2008.09.075
CHEMBL407196 9585 20 None -26 6 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins before with SR-48692 by FLIPR assayAntagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins before with SR-48692 by FLIPR assay
ChEMBL None None None None 10.1016/j.bmcl.2008.09.075
119192 9259 54 None 1 4 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as inhibition of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAntagonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as inhibition of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2014.06.033
1582 9259 54 None 1 4 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as inhibition of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAntagonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as inhibition of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2014.06.033
CHEMBL506981 9259 54 None 1 4 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as inhibition of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAntagonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as inhibition of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2014.06.033
DB06455 9259 54 None 1 4 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as inhibition of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assayAntagonist activity at NTSR1 (unknown origin) expressed in CHO cells assessed as inhibition of NT(8-13) peptide-induced change in intracellular Ca2+ level preincubated for 45 mins by FLIPR assay
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2014.06.033
CHEMBL2310906 216278 0 None - 0 Human 8.3 pKi = 8.3 Functional
Activity at wild type human NTR1 expressed in HEK293 cells assessed as increase in intracellular calcium levelActivity at wild type human NTR1 expressed in HEK293 cells assessed as increase in intracellular calcium level
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2008.08.051
1576 9055 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11811984
5307 7014 0 None - 1 Rat 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 20481538
5307 7014 0 None - 1 Rat 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 30986796
119192 9259 54 None 1 4 Human 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 9023294
1582 9259 54 None 1 4 Human 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 9023294
CHEMBL506981 9259 54 None 1 4 Human 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 9023294
DB06455 9259 54 None 1 4 Human 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 9023294
5306 8966 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16095636
46866109 7013 0 None - 1 Mouse 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None NCCCCC[C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](C(C)(C)C)C(=O)N[C@H](C(=O)O)CC(C)C)Cc1ccc(cc1)O)CCCNC(=N)N)C 22459147
46866109 7013 0 None - 1 Mouse 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None NCCCCC[C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](C(C)(C)C)C(=O)N[C@H](C(=O)O)CC(C)C)Cc1ccc(cc1)O)CCCNC(=N)N)C 31770520
5308 7013 0 None - 1 Mouse 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None NCCCCC[C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](C(C)(C)C)C(=O)N[C@H](C(=O)O)CC(C)C)Cc1ccc(cc1)O)CCCNC(=N)N)C 22459147
5308 7013 0 None - 1 Mouse 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None NCCCCC[C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](C(C)(C)C)C(=O)N[C@H](C(=O)O)CC(C)C)Cc1ccc(cc1)O)CCCNC(=N)N)C 31770520
CHEMBL1170625 7013 0 None - 1 Mouse 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None NCCCCC[C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](C(C)(C)C)C(=O)N[C@H](C(=O)O)CC(C)C)Cc1ccc(cc1)O)CCCNC(=N)N)C 22459147
CHEMBL1170625 7013 0 None - 1 Mouse 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None NCCCCC[C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](C(C)(C)C)C(=O)N[C@H](C(=O)O)CC(C)C)Cc1ccc(cc1)O)CCCNC(=N)N)C 31770520
1577 9058 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11811984
1580 10437 46 None 1 2 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 9023294
5311451 10437 46 None 1 2 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 9023294
CHEMBL3040381 10437 46 None 1 2 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 9023294
1575 7948 0 None -1 3 Human 6.0 pIC50 None 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10318778
1575 7948 0 None 1 3 Rat 6.3 pIC50 None 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10318778
101205709 10586 0 None -3 3 Rat 7.1 pIC50 None 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10318778
1573 10586 0 None -3 3 Rat 7.1 pIC50 None 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10318778
101205709 10586 0 None 3 3 Human 7.6 pIC50 None 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10318778
1573 10586 0 None 3 3 Human 7.6 pIC50 None 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10318778




Ligands Receptor Assay information Chemical information
Sel. page Common
name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Affinity)
# tested GPCRs
(Affinity)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
644241 101961 121 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 529 6 2 7 6.4 Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 10.1038/s41467-023-40064-9
CHEMBL255863 101961 121 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 529 6 2 7 6.4 Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 10.1038/s41467-023-40064-9
2519 7566 86 None - 12 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 194 0 0 6 -1.0 Cn1cnc2c1c(=O)n(C)c(=O)n2C 10.1038/s41467-023-40064-9
407 7566 86 None - 12 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 194 0 0 6 -1.0 Cn1cnc2c1c(=O)n(C)c(=O)n2C 10.1038/s41467-023-40064-9
463 7566 86 None - 12 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 194 0 0 6 -1.0 Cn1cnc2c1c(=O)n(C)c(=O)n2C 10.1038/s41467-023-40064-9
CHEMBL113 7566 86 None - 12 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 194 0 0 6 -1.0 Cn1cnc2c1c(=O)n(C)c(=O)n2C 10.1038/s41467-023-40064-9
DB00201 7566 86 None - 12 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 194 0 0 6 -1.0 Cn1cnc2c1c(=O)n(C)c(=O)n2C 10.1038/s41467-023-40064-9
2997 199930 35 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 270 1 1 2 3.1 O=C1CN=C(c2ccccc2)c2cc(Cl)ccc2N1 10.1038/s41467-023-40064-9
CHEMBL523 199930 35 None - 0 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 270 1 1 2 3.1 O=C1CN=C(c2ccccc2)c2cc(Cl)ccc2N1 10.1038/s41467-023-40064-9
8730 202670 72 None - 0 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 777 5 3 4 4.6 N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O 10.1038/s41467-023-40064-9
90657408 202670 72 None - 0 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 777 5 3 4 4.6 N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL559 202670 72 None - 0 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 777 5 3 4 4.6 N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O 10.1038/s41467-023-40064-9
5411 210812 89 None - 2 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 264 8 1 4 2.6 CCCCNc1ccc(C(=O)OCCN(C)C)cc1 10.1038/s41467-023-40064-9
CHEMBL698 210812 89 None - 2 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 264 8 1 4 2.6 CCCCNc1ccc(C(=O)OCCN(C)C)cc1 10.1038/s41467-023-40064-9
CHEMBL3622803 218661 0 None - 0 Human 9.5 pEC50 = 9.5 Binding
Agonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing hNTS1-GFP10/RlucII-beta-arrestin 2 assessed as beta-arrestin2 recruitment incubated for 15 mins by BRET assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing hNTS1-GFP10/RlucII-beta-arrestin 2 assessed as beta-arrestin2 recruitment incubated for 15 mins by BRET assay
ChEMBL None None None C[Si](C)(C)C[C@H](NC(=O)[C@H](C[Si](C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)O 10.1021/acs.jmedchem.5b00841
1569 8907 32 None - 2 Rat 8.9 pEC50 = 8.9 Binding
Agonist activity at human NTS1 in Sprague-Dawley rat ileum assessed as inhibition of carbachol-induced contractionAgonist activity at human NTS1 in Sprague-Dawley rat ileum assessed as inhibition of carbachol-induced contraction
ChEMBL None None None None 10.1021/acs.jmedchem.5b00841
5311318 8907 32 None - 2 Rat 8.9 pEC50 = 8.9 Binding
Agonist activity at human NTS1 in Sprague-Dawley rat ileum assessed as inhibition of carbachol-induced contractionAgonist activity at human NTS1 in Sprague-Dawley rat ileum assessed as inhibition of carbachol-induced contraction
ChEMBL None None None None 10.1021/acs.jmedchem.5b00841
CHEMBL415788 8907 32 None - 2 Rat 8.9 pEC50 = 8.9 Binding
Agonist activity at human NTS1 in Sprague-Dawley rat ileum assessed as inhibition of carbachol-induced contractionAgonist activity at human NTS1 in Sprague-Dawley rat ileum assessed as inhibition of carbachol-induced contraction
ChEMBL None None None None 10.1021/acs.jmedchem.5b00841
CHEMBL3622802 218660 0 None - 0 Rat 8.9 pEC50 = 8.9 Binding
Agonist activity at human NTS1 in Sprague-Dawley rat ileum assessed as inhibition of carbachol-induced contractionAgonist activity at human NTS1 in Sprague-Dawley rat ileum assessed as inhibition of carbachol-induced contraction
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](C[Si](C)(C)C)C(=O)O 10.1021/acs.jmedchem.5b00841
1569 8907 32 None 2 2 Human 8.9 pEC50 = 8.9 Binding
Agonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing Galphaq-RlucII(121)/Gbeta1/GFP10-Ggamma1 assessed as Galpha-q stimulation incubated for 15 mins by BRET assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing Galphaq-RlucII(121)/Gbeta1/GFP10-Ggamma1 assessed as Galpha-q stimulation incubated for 15 mins by BRET assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b00841
5311318 8907 32 None 2 2 Human 8.9 pEC50 = 8.9 Binding
Agonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing Galphaq-RlucII(121)/Gbeta1/GFP10-Ggamma1 assessed as Galpha-q stimulation incubated for 15 mins by BRET assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing Galphaq-RlucII(121)/Gbeta1/GFP10-Ggamma1 assessed as Galpha-q stimulation incubated for 15 mins by BRET assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b00841
CHEMBL415788 8907 32 None 2 2 Human 8.9 pEC50 = 8.9 Binding
Agonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing Galphaq-RlucII(121)/Gbeta1/GFP10-Ggamma1 assessed as Galpha-q stimulation incubated for 15 mins by BRET assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing Galphaq-RlucII(121)/Gbeta1/GFP10-Ggamma1 assessed as Galpha-q stimulation incubated for 15 mins by BRET assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b00841
CHEMBL3622802 218660 0 None - 0 Human 8.8 pEC50 = 8.8 Binding
Agonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing hNTS1-GFP10/RlucII-beta-arrestin 2 assessed as beta-arrestin2 recruitment incubated for 15 mins by BRET assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing hNTS1-GFP10/RlucII-beta-arrestin 2 assessed as beta-arrestin2 recruitment incubated for 15 mins by BRET assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](C[Si](C)(C)C)C(=O)O 10.1021/acs.jmedchem.5b00841
CHEMBL3622802 218660 0 None - 0 Human 8.8 pEC50 = 8.8 Binding
Agonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing Galphaq-RlucII(121)/Gbeta1/GFP10-Ggamma1 assessed as Galpha-q stimulation incubated for 15 mins by BRET assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing Galphaq-RlucII(121)/Gbeta1/GFP10-Ggamma1 assessed as Galpha-q stimulation incubated for 15 mins by BRET assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](C[Si](C)(C)C)C(=O)O 10.1021/acs.jmedchem.5b00841
1569 8907 32 None 2 2 Human 8.7 pEC50 = 8.7 Binding
Agonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing hNTS1-GFP10/RlucII-beta-arrestin 2 assessed as beta-arrestin2 recruitment incubated for 15 mins by BRET assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing hNTS1-GFP10/RlucII-beta-arrestin 2 assessed as beta-arrestin2 recruitment incubated for 15 mins by BRET assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b00841
5311318 8907 32 None 2 2 Human 8.7 pEC50 = 8.7 Binding
Agonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing hNTS1-GFP10/RlucII-beta-arrestin 2 assessed as beta-arrestin2 recruitment incubated for 15 mins by BRET assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing hNTS1-GFP10/RlucII-beta-arrestin 2 assessed as beta-arrestin2 recruitment incubated for 15 mins by BRET assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b00841
CHEMBL415788 8907 32 None 2 2 Human 8.7 pEC50 = 8.7 Binding
Agonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing hNTS1-GFP10/RlucII-beta-arrestin 2 assessed as beta-arrestin2 recruitment incubated for 15 mins by BRET assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing hNTS1-GFP10/RlucII-beta-arrestin 2 assessed as beta-arrestin2 recruitment incubated for 15 mins by BRET assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b00841
16127648 21137 0 None - 1 Human 8.0 pEC50 = 8.0 Binding
Binding affinity to human NTR1 by gamma countingBinding affinity to human NTR1 by gamma counting
ChEMBL 817 22 9 8 1.4 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O 10.1021/jm100092s
CHEMBL1172376 21137 0 None - 1 Human 8.0 pEC50 = 8.0 Binding
Binding affinity to human NTR1 by gamma countingBinding affinity to human NTR1 by gamma counting
ChEMBL 817 22 9 8 1.4 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O 10.1021/jm100092s
CHEMBL1200171 21137 0 None - 1 Human 8.0 pEC50 = 8.0 Binding
Binding affinity to human NTR1 by gamma countingBinding affinity to human NTR1 by gamma counting
ChEMBL 817 22 9 8 1.4 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCC[N+](C)(C)C)C(C)(C)C)C(=O)O 10.1021/jm100092s
1580 10437 46 None 1 4 Human 5.0 pEC50 = 5 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/ml400176n
5311451 10437 46 None 1 4 Human 5.0 pEC50 = 5 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/ml400176n
CHEMBL3040381 10437 46 None 1 4 Human 5.0 pEC50 = 5 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/ml400176n
53245521 99178 1 None - 0 Human 5.0 pEC50 = 5 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 404 5 0 6 4.2 COc1ccc2nc(C3CCC3)nc(N3CCN(c4ccccc4OC)CC3)c2c1 10.1021/ml400176n
CHEMBL2431125 99178 1 None - 0 Human 5.0 pEC50 = 5 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 404 5 0 6 4.2 COc1ccc2nc(C3CCC3)nc(N3CCN(c4ccccc4OC)CC3)c2c1 10.1021/ml400176n
118610278 176289 0 None - 0 Human 5.0 pEC50 = 5 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 430 7 0 5 5.7 CCCN(C)c1ccc2c(N3CCC(c4ccccc4OC)CC3)nc(C3CC3)nc2c1 10.1021/acs.jmedchem.9b00340
CHEMBL4434705 176289 0 None - 0 Human 5.0 pEC50 = 5 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 430 7 0 5 5.7 CCCN(C)c1ccc2c(N3CCC(c4ccccc4OC)CC3)nc(C3CC3)nc2c1 10.1021/acs.jmedchem.9b00340
118617781 181966 0 None - 0 Human 6.0 pEC50 = 6 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 444 5 1 6 4.5 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N4CC[C@H](O)C4)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4570744 181966 0 None - 0 Human 6.0 pEC50 = 6 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 444 5 1 6 4.5 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N4CC[C@H](O)C4)cc23)CC1 10.1021/acs.jmedchem.9b00340
90237596 178928 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 419 6 0 6 4.9 COc1cc2nc(C3CC3)nc(N3CCC(c4ccccc4OC)CC3)c2cc1OC 10.1021/acs.jmedchem.9b00340
CHEMBL4473181 178928 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 419 6 0 6 4.9 COc1cc2nc(C3CC3)nc(N3CCC(c4ccccc4OC)CC3)c2cc1OC 10.1021/acs.jmedchem.9b00340
118610372 178739 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 446 7 1 6 4.7 COc1ccccc1C1CCN(c2nc(C3CCC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4470647 178739 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 446 7 1 6 4.7 COc1ccccc1C1CCN(c2nc(C3CCC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
118610470 177485 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 464 8 0 6 5.1 COCCN(C)c1ccc2nc(C3(F)CC3)nc(N3CCC(c4ccccc4OC)CC3)c2c1 10.1021/acs.jmedchem.9b00340
CHEMBL4451959 177485 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 464 8 0 6 5.1 COCCN(C)c1ccc2nc(C3(F)CC3)nc(N3CCC(c4ccccc4OC)CC3)c2c1 10.1021/acs.jmedchem.9b00340
CHEMBL3622803 218661 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Agonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing Galphaq-RlucII(121)/Gbeta1/GFP10-Ggamma1 assessed as Galpha-q stimulation incubated for 15 mins by BRET assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing Galphaq-RlucII(121)/Gbeta1/GFP10-Ggamma1 assessed as Galpha-q stimulation incubated for 15 mins by BRET assay
ChEMBL None None None C[Si](C)(C)C[C@H](NC(=O)[C@H](C[Si](C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)O 10.1021/acs.jmedchem.5b00841
90237648 182954 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 446 8 0 6 5.0 COCCN(C)c1ccc2nc(C3CC3)nc(N3CCC(c4ccccc4OC)CC3)c2c1 10.1021/acs.jmedchem.9b00340
CHEMBL4593175 182954 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 446 8 0 6 5.0 COCCN(C)c1ccc2nc(C3CC3)nc(N3CCC(c4ccccc4OC)CC3)c2c1 10.1021/acs.jmedchem.9b00340
51035368 99243 0 None - 0 Human 4.9 pEC50 = 4.9 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 404 5 0 6 4.2 COc1cc2nc(C3CCC3)nc(N3CCN(c4ccccc4)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL2431231 99243 0 None - 0 Human 4.9 pEC50 = 4.9 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 404 5 0 6 4.2 COc1cc2nc(C3CCC3)nc(N3CCN(c4ccccc4)CC3)c2cc1OC 10.1021/ml400176n
52914819 99246 0 None - 0 Human 4.9 pEC50 = 4.9 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 438 5 0 6 4.9 COc1cc2nc(C3CCC3)nc(N3CCN(c4ccccc4Cl)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL2431234 99246 0 None - 0 Human 4.9 pEC50 = 4.9 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 438 5 0 6 4.9 COc1cc2nc(C3CCC3)nc(N3CCN(c4ccccc4Cl)CC3)c2cc1OC 10.1021/ml400176n
118617733 176515 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 446 7 1 6 4.6 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N(C)CCO)c(C)c23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4438479 176515 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 446 7 1 6 4.6 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N(C)CCO)c(C)c23)CC1 10.1021/acs.jmedchem.9b00340
118610427 182215 25 None - 0 Human 6.9 pEC50 = 6.9 Binding
Positive allosteric modulation of recombinant human NTR1 expressed in HEK293 cells assessed as increase in [125I]-neurotensin binding measured after 45 minsPositive allosteric modulation of recombinant human NTR1 expressed in HEK293 cells assessed as increase in [125I]-neurotensin binding measured after 45 mins
ChEMBL 450 7 1 6 4.4 COc1ccccc1C1CCN(c2nc(C3(F)CC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4576388 182215 25 None - 0 Human 6.9 pEC50 = 6.9 Binding
Positive allosteric modulation of recombinant human NTR1 expressed in HEK293 cells assessed as increase in [125I]-neurotensin binding measured after 45 minsPositive allosteric modulation of recombinant human NTR1 expressed in HEK293 cells assessed as increase in [125I]-neurotensin binding measured after 45 mins
ChEMBL 450 7 1 6 4.4 COc1ccccc1C1CCN(c2nc(C3(F)CC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
53245615 99168 0 None - 0 Human 4.9 pEC50 = 4.9 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 470 7 0 7 4.6 COc1cc2nc(Cc3ccccc3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL2431114 99168 0 None - 0 Human 4.9 pEC50 = 4.9 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 470 7 0 7 4.6 COc1cc2nc(Cc3ccccc3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
56593284 99176 0 None - 0 Human 4.9 pEC50 = 4.9 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 434 7 0 7 3.9 COc1cc2nc(CC3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL2431122 99176 0 None - 0 Human 4.9 pEC50 = 4.9 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 434 7 0 7 3.9 COc1cc2nc(CC3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
118617715 176652 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 448 7 0 5 5.8 CCCN(C)c1ccc2nc(C3(F)CC3)nc(N3CCC(c4ccccc4OC)CC3)c2c1 10.1021/acs.jmedchem.9b00340
CHEMBL4440438 176652 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 448 7 0 5 5.8 CCCN(C)c1ccc2nc(C3(F)CC3)nc(N3CCC(c4ccccc4OC)CC3)c2c1 10.1021/acs.jmedchem.9b00340
118617724 176528 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 460 7 1 6 4.9 COc1ccccc1C1CCN(c2nc(C3(C)CCC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4438637 176528 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 460 7 1 6 4.9 COc1ccccc1C1CCN(c2nc(C3(C)CCC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
56593282 99172 0 None - 0 Human 4.8 pEC50 = 4.8 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 436 7 0 7 4.2 COc1cc2nc(CC(C)C)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL2431118 99172 0 None - 0 Human 4.8 pEC50 = 4.8 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 436 7 0 7 4.2 COc1cc2nc(CC(C)C)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
51035373 99244 0 None - 0 Human 4.8 pEC50 = 4.8 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 418 5 0 6 4.6 COc1cc2nc(C3CCC3)nc(N3CCN(c4ccccc4C)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL2431232 99244 0 None - 0 Human 4.8 pEC50 = 4.8 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 418 5 0 6 4.6 COc1cc2nc(C3CCC3)nc(N3CCN(c4ccccc4C)CC3)c2cc1OC 10.1021/ml400176n
118610338 179728 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 446 7 1 6 4.6 COc1ccccc1C1CCN(c2nc(C3CC3)nc3c(C)cc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4517098 179728 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 446 7 1 6 4.6 COc1ccccc1C1CCN(c2nc(C3CC3)nc3c(C)cc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
118610426 180771 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 450 7 1 6 4.5 COc1ccccc1C1CCN(c2nc(C3CC3)nc3c(F)cc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4542358 180771 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 450 7 1 6 4.5 COc1ccccc1C1CCN(c2nc(C3CC3)nc3c(F)cc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL3622801 218659 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing Galphaq-RlucII(121)/Gbeta1/GFP10-Ggamma1 assessed as Galpha-q stimulation incubated for 15 mins by BRET assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing Galphaq-RlucII(121)/Gbeta1/GFP10-Ggamma1 assessed as Galpha-q stimulation incubated for 15 mins by BRET assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C[Si](C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)O 10.1021/acs.jmedchem.5b00841
54758538 99170 1 None - 0 Human 4.8 pEC50 = 4.8 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 422 7 0 7 3.9 CCCc1nc(N2CCN(c3ccccc3OC)CC2)c2cc(OC)c(OC)cc2n1 10.1021/ml400176n
CHEMBL2431116 99170 1 None - 0 Human 4.8 pEC50 = 4.8 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 422 7 0 7 3.9 CCCc1nc(N2CCN(c3ccccc3OC)CC2)c2cc(OC)c(OC)cc2n1 10.1021/ml400176n
73349346 99248 0 None - 0 Human 4.8 pEC50 = 4.8 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 470 7 0 7 5.0 CCOc1cc2c(N3CCN(c4cccc(OC)c4)CC3)nc(-c3ccccc3)nc2cc1OC 10.1021/ml400176n
CHEMBL2431236 99248 0 None - 0 Human 4.8 pEC50 = 4.8 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 470 7 0 7 5.0 CCOc1cc2c(N3CCN(c4cccc(OC)c4)CC3)nc(-c3ccccc3)nc2cc1OC 10.1021/ml400176n
118617570 182028 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 519 8 0 7 4.7 COc1ccccc1C1CCN(c2nc(C3(F)CC3)nc3ccc(N(C)CCN4CCOCC4)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4572231 182028 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 519 8 0 7 4.7 COc1ccccc1C1CCN(c2nc(C3(F)CC3)nc3ccc(N(C)CCN4CCOCC4)cc23)CC1 10.1021/acs.jmedchem.9b00340
52914822 99245 0 None - 0 Human 4.8 pEC50 = 4.8 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 422 5 0 6 4.4 COc1cc2nc(C3CCC3)nc(N3CCN(c4ccccc4F)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL2431233 99245 0 None - 0 Human 4.8 pEC50 = 4.8 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 422 5 0 6 4.4 COc1cc2nc(C3CCC3)nc(N3CCN(c4ccccc4F)CC3)c2cc1OC 10.1021/ml400176n
162673667 189880 0 None - 0 Rat 7.7 pEC50 = 7.7 Binding
Agonist activity at rat NTR1 expressed in CHO cells assessed as effect on [3H] phosphoinositide accumulation using neurotensin (1 to 13 residues) as substrate by radioactive assayAgonist activity at rat NTR1 expressed in CHO cells assessed as effect on [3H] phosphoinositide accumulation using neurotensin (1 to 13 residues) as substrate by radioactive assay
ChEMBL 2214 71 33 31 -6.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)CN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)O 10.1039/d0md00173b
CHEMBL4794546 189880 0 None - 0 Rat 7.7 pEC50 = 7.7 Binding
Agonist activity at rat NTR1 expressed in CHO cells assessed as effect on [3H] phosphoinositide accumulation using neurotensin (1 to 13 residues) as substrate by radioactive assayAgonist activity at rat NTR1 expressed in CHO cells assessed as effect on [3H] phosphoinositide accumulation using neurotensin (1 to 13 residues) as substrate by radioactive assay
ChEMBL 2214 71 33 31 -6.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)CN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)O 10.1039/d0md00173b
53245590 99174 43 None - 4 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 420 6 0 7 3.9 COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL2431120 99174 43 None - 4 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 420 6 0 7 3.9 COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
49837912 111069 3 None - 1 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
CHEMBL3099773 111069 3 None - 1 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
56593272 99184 1 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 424 5 0 6 4.5 COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4Cl)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL2431131 99184 1 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 424 5 0 6 4.5 COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4Cl)CC3)c2cc1OC 10.1021/ml400176n
4679731 99185 8 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 456 6 0 7 4.6 COc1cc2nc(-c3ccccc3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL2431133 99185 8 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 456 6 0 7 4.6 COc1cc2nc(-c3ccccc3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL3622805 218663 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing Galphaq-RlucII(121)/Gbeta1/GFP10-Ggamma1 assessed as Galpha-q stimulation incubated for 15 mins by BRET assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing Galphaq-RlucII(121)/Gbeta1/GFP10-Ggamma1 assessed as Galpha-q stimulation incubated for 15 mins by BRET assay
ChEMBL None None None CN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C[Si](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b00841
CHEMBL3622803 218661 0 None - 0 Rat 7.7 pEC50 = 7.7 Binding
Agonist activity at human NTS1 in Sprague-Dawley rat ileum assessed as inhibition of carbachol-induced contractionAgonist activity at human NTS1 in Sprague-Dawley rat ileum assessed as inhibition of carbachol-induced contraction
ChEMBL None None None C[Si](C)(C)C[C@H](NC(=O)[C@H](C[Si](C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)O 10.1021/acs.jmedchem.5b00841
118617949 178439 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 466 7 1 6 5.0 COc1ccccc1C1CCN(c2nc(C3CC3)nc3c(Cl)cc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4466155 178439 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 466 7 1 6 5.0 COc1ccccc1C1CCN(c2nc(C3CC3)nc3c(Cl)cc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
118617631 182682 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 460 8 0 6 5.2 COCCN(C)c1ccc2nc(C3(C)CC3)nc(N3CCC(c4ccccc4OC)CC3)c2c1 10.1021/acs.jmedchem.9b00340
CHEMBL4586953 182682 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 460 8 0 6 5.2 COCCN(C)c1ccc2nc(C3(C)CC3)nc(N3CCC(c4ccccc4OC)CC3)c2c1 10.1021/acs.jmedchem.9b00340
50919376 111066 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 487 9 2 6 4.9 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1cccc2ccccc12 10.1016/j.bmcl.2013.11.026
CHEMBL3099769 111066 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 487 9 2 6 4.9 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1cccc2ccccc12 10.1016/j.bmcl.2013.11.026
53245626 99180 1 None - 0 Human 4.6 pEC50 = 4.6 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 374 4 0 5 4.2 COc1ccccc1N1CCN(c2nc(C3CCC3)nc3ccccc23)CC1 10.1021/ml400176n
CHEMBL2431127 99180 1 None - 0 Human 4.6 pEC50 = 4.6 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 374 4 0 5 4.2 COc1ccccc1N1CCN(c2nc(C3CCC3)nc3ccccc23)CC1 10.1021/ml400176n
73350917 99250 0 None - 0 Human 4.6 pEC50 = 4.6 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 500 8 0 8 5.0 CCOc1cc2c(N3CCN(c4ccc(OC)cc4OC)CC3)nc(-c3ccccc3)nc2cc1OC 10.1021/ml400176n
CHEMBL2431238 99250 0 None - 0 Human 4.6 pEC50 = 4.6 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 500 8 0 8 5.0 CCOc1cc2c(N3CCN(c4ccc(OC)cc4OC)CC3)nc(-c3ccccc3)nc2cc1OC 10.1021/ml400176n
56593291 99163 1 None - 0 Human 4.6 pEC50 = 4.6 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 418 6 0 6 4.2 COc1cc2nc(C3CC3)nc(N3CCN(Cc4ccc(C)cc4)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL2431106 99163 1 None - 0 Human 4.6 pEC50 = 4.6 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 418 6 0 6 4.2 COc1cc2nc(C3CC3)nc(N3CCN(Cc4ccc(C)cc4)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL3622801 218659 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing hNTS1-GFP10/RlucII-beta-arrestin 2 assessed as beta-arrestin2 recruitment incubated for 15 mins by BRET assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing hNTS1-GFP10/RlucII-beta-arrestin 2 assessed as beta-arrestin2 recruitment incubated for 15 mins by BRET assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C[Si](C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)O 10.1021/acs.jmedchem.5b00841
1230851 39898 3 None - 0 Human 4.6 pEC50 = 4.6 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 405 5 0 7 3.6 COc1cc2nc(C3CCC3)nc(N3CCN(c4ccccn4)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL1417160 39898 3 None - 0 Human 4.6 pEC50 = 4.6 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 405 5 0 7 3.6 COc1cc2nc(C3CCC3)nc(N3CCN(c4ccccn4)CC3)c2cc1OC 10.1021/ml400176n
56593281 99177 0 None - 0 Human 4.6 pEC50 = 4.6 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 598 10 0 10 4.4 COc1cc2nc(CCN3CCN(c4ccccc4OC)CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL2431124 99177 0 None - 0 Human 4.6 pEC50 = 4.6 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 598 10 0 10 4.4 COc1cc2nc(CCN3CCN(c4ccccc4OC)CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
118610423 177686 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 464 7 1 6 4.8 COc1ccccc1C1CCN(c2nc(C3(F)CCC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4454815 177686 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 464 7 1 6 4.8 COc1ccccc1C1CCN(c2nc(C3(F)CCC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
118610386 178085 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 472 6 0 6 5.5 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N4CCC(OC)CC4)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4460973 178085 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 472 6 0 6 5.5 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N4CCC(OC)CC4)cc23)CC1 10.1021/acs.jmedchem.9b00340
53245590 99174 43 None - 4 Human 5.5 pEC50 = 5.5 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 420 6 0 7 3.9 COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/acs.jmedchem.9b00340
CHEMBL2431120 99174 43 None - 4 Human 5.5 pEC50 = 5.5 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 420 6 0 7 3.9 COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/acs.jmedchem.9b00340
53245542 99179 1 None - 0 Human 4.5 pEC50 = 4.5 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 404 5 0 6 4.2 COc1ccc2c(N3CCN(c4ccccc4OC)CC3)nc(C3CCC3)nc2c1 10.1021/ml400176n
CHEMBL2431126 99179 1 None - 0 Human 4.5 pEC50 = 4.5 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 404 5 0 6 4.2 COc1ccc2c(N3CCN(c4ccccc4OC)CC3)nc(C3CCC3)nc2c1 10.1021/ml400176n
118617560 177570 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 448 7 0 5 5.9 CCCN(C)c1cc2c(N3CCC(c4ccccc4OC)CC3)nc(C3CC3)nc2cc1F 10.1021/acs.jmedchem.9b00340
CHEMBL4453074 177570 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 448 7 0 5 5.9 CCCN(C)c1cc2c(N3CCC(c4ccccc4OC)CC3)nc(C3CC3)nc2cc1F 10.1021/acs.jmedchem.9b00340
119192 9259 54 None -3 9 Human 4.5 pEC50 = 4.5 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2013.11.026
1582 9259 54 None -3 9 Human 4.5 pEC50 = 4.5 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2013.11.026
CHEMBL506981 9259 54 None -3 9 Human 4.5 pEC50 = 4.5 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2013.11.026
DB06455 9259 54 None -3 9 Human 4.5 pEC50 = 4.5 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2013.11.026
90237301 179051 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 515 8 0 7 4.8 COc1ccccc1C1CCN(c2nc(C3(C)CC3)nc3ccc(N(C)CCN4CCOCC4)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4474648 179051 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 515 8 0 7 4.8 COc1ccccc1C1CCN(c2nc(C3(C)CC3)nc3ccc(N(C)CCN4CCOCC4)cc23)CC1 10.1021/acs.jmedchem.9b00340
118610411 178610 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 500 7 1 6 5.0 COc1ccccc1C1CCN(c2nc(C3(C(F)(F)F)CC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4468649 178610 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 500 7 1 6 5.0 COc1ccccc1C1CCN(c2nc(C3(C(F)(F)F)CC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
118610427 182215 25 None - 0 Human 6.5 pEC50 = 6.5 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 450 7 1 6 4.4 COc1ccccc1C1CCN(c2nc(C3(F)CC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4576388 182215 25 None - 0 Human 6.5 pEC50 = 6.5 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 450 7 1 6 4.4 COc1ccccc1C1CCN(c2nc(C3(F)CC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
53245574 99181 0 None - 0 Human 4.5 pEC50 = 4.5 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 418 4 0 7 4.0 COc1ccccc1N1CCN(c2nc(C3CCC3)nc3cc4c(cc23)OCO4)CC1 10.1021/ml400176n
CHEMBL2431128 99181 0 None - 0 Human 4.5 pEC50 = 4.5 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 418 4 0 7 4.0 COc1ccccc1N1CCN(c2nc(C3CCC3)nc3cc4c(cc23)OCO4)CC1 10.1021/ml400176n
53245590 99174 43 None - 4 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at NTR1 (unknown origin) expressed in CHOK1 cells by beta-arrestin assayAgonist activity at NTR1 (unknown origin) expressed in CHOK1 cells by beta-arrestin assay
ChEMBL 420 6 0 7 3.9 COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL2431120 99174 43 None - 4 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at NTR1 (unknown origin) expressed in CHOK1 cells by beta-arrestin assayAgonist activity at NTR1 (unknown origin) expressed in CHOK1 cells by beta-arrestin assay
ChEMBL 420 6 0 7 3.9 COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
56593288 99164 0 None - 0 Human 4.5 pEC50 = 4.5 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 434 7 0 7 3.9 COc1ccccc1CN1CCN(c2nc(C3CC3)nc3cc(OC)c(OC)cc23)CC1 10.1021/ml400176n
CHEMBL2431107 99164 0 None - 0 Human 4.5 pEC50 = 4.5 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 434 7 0 7 3.9 COc1ccccc1CN1CCN(c2nc(C3CC3)nc3cc(OC)c(OC)cc23)CC1 10.1021/ml400176n
50919365 111073 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 488 9 2 7 4.3 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1ccnc2ccccc12 10.1016/j.bmcl.2013.11.026
CHEMBL3099777 111073 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 488 9 2 7 4.3 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1ccnc2ccccc12 10.1016/j.bmcl.2013.11.026
118617792 177204 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 569 8 0 7 5.4 COc1ccccc1C1CCN(c2nc(C3(C(F)(F)F)CC3)nc3ccc(N(C)CCN4CCOCC4)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4448328 177204 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 569 8 0 7 5.4 COc1ccccc1C1CCN(c2nc(C3(C(F)(F)F)CC3)nc3ccc(N(C)CCN4CCOCC4)cc23)CC1 10.1021/acs.jmedchem.9b00340
118610255 176454 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 460 7 1 6 5.1 COc1ccccc1C1CCN(c2nc(C3CCCC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4437603 176454 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 460 7 1 6 5.1 COc1ccccc1C1CCN(c2nc(C3CCCC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL3622805 218663 0 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing hNTS1-GFP10/RlucII-beta-arrestin 2 assessed as beta-arrestin2 recruitment incubated for 15 mins by BRET assayAgonist activity at human NTS1 receptor expressed in CHOK1 cells co-expressing hNTS1-GFP10/RlucII-beta-arrestin 2 assessed as beta-arrestin2 recruitment incubated for 15 mins by BRET assay
ChEMBL None None None CN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C[Si](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b00841
56593278 99182 1 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 390 5 0 6 3.9 COc1ccc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2c1 10.1021/ml400176n
CHEMBL2431129 99182 1 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 390 5 0 6 3.9 COc1ccc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2c1 10.1021/ml400176n
118610246 178336 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 468 7 1 6 5.1 COc1ccccc1C1CCN(c2nc(-c3ccccc3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4464635 178336 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 468 7 1 6 5.1 COc1ccccc1C1CCN(c2nc(-c3ccccc3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
56593293 99169 1 None - 0 Human 4.4 pEC50 = 4.4 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 408 6 0 7 3.5 CCc1nc(N2CCN(c3ccccc3OC)CC2)c2cc(OC)c(OC)cc2n1 10.1021/ml400176n
CHEMBL2431115 99169 1 None - 0 Human 4.4 pEC50 = 4.4 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 408 6 0 7 3.5 CCc1nc(N2CCN(c3ccccc3OC)CC2)c2cc(OC)c(OC)cc2n1 10.1021/ml400176n
118617787 177140 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 444 5 1 6 4.5 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N4CC[C@@H](O)C4)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4447601 177140 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 444 5 1 6 4.5 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N4CC[C@@H](O)C4)cc23)CC1 10.1021/acs.jmedchem.9b00340
56593289 99165 0 None - 0 Human 4.4 pEC50 = 4.4 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 418 5 0 6 3.5 COc1cc2nc(C3CC3)nc(N3CCN(C(=O)c4ccccc4)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL2431108 99165 0 None - 0 Human 4.4 pEC50 = 4.4 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 418 5 0 6 3.5 COc1cc2nc(C3CC3)nc(N3CCN(C(=O)c4ccccc4)CC3)c2cc1OC 10.1021/ml400176n
73355398 99249 0 None - 0 Human 4.3 pEC50 = 4.3 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 470 7 0 7 5.0 CCOc1cc2c(N3CCN(c4ccc(OC)cc4)CC3)nc(-c3ccccc3)nc2cc1OC 10.1021/ml400176n
CHEMBL2431237 99249 0 None - 0 Human 4.3 pEC50 = 4.3 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 470 7 0 7 5.0 CCOc1cc2c(N3CCN(c4ccc(OC)cc4)CC3)nc(-c3ccccc3)nc2cc1OC 10.1021/ml400176n
50919370 111067 0 None - 0 Human 4.3 pEC50 = 4.3 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 586 7 2 7 5.8 COc1cccc(OC)c1-c1nc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)cn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
CHEMBL3099771 111067 0 None - 0 Human 4.3 pEC50 = 4.3 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 586 7 2 7 5.8 COc1cccc(OC)c1-c1nc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)cn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
90237403 180449 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 432 7 1 6 4.3 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4534863 180449 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 432 7 1 6 4.3 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
118610402 177011 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 466 7 1 6 5.0 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N(C)CCO)c(Cl)c23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4445632 177011 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 466 7 1 6 5.0 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N(C)CCO)c(Cl)c23)CC1 10.1021/acs.jmedchem.9b00340
50919363 111064 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 530 7 2 5 6.3 CC(C)C[C@H](NC(=O)c1cn(-c2ccnc3cc(Cl)ccc23)c(-c2c(Cl)cccc2Cl)n1)C(=O)O 10.1016/j.bmcl.2013.11.026
CHEMBL3099767 111064 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 530 7 2 5 6.3 CC(C)C[C@H](NC(=O)c1cn(-c2ccnc3cc(Cl)ccc23)c(-c2c(Cl)cccc2Cl)n1)C(=O)O 10.1016/j.bmcl.2013.11.026
118617645 177304 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 446 7 1 6 4.6 COc1ccccc1C1CCN(c2nc(C3CC3)nc3cc(C)c(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4449708 177304 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 446 7 1 6 4.6 COc1ccccc1C1CCN(c2nc(C3CC3)nc3cc(C)c(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
90236942 178139 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 416 6 0 5 5.4 CCN(C)c1ccc2nc(C3CC3)nc(N3CCC(c4ccccc4OC)CC3)c2c1 10.1021/acs.jmedchem.9b00340
CHEMBL4461671 178139 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 416 6 0 5 5.4 CCN(C)c1ccc2nc(C3CC3)nc(N3CCC(c4ccccc4OC)CC3)c2c1 10.1021/acs.jmedchem.9b00340
49837903 111071 0 None - 0 Human 4.3 pEC50 = 4.3 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 492 8 2 6 5.0 COc1ccccc1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
CHEMBL3099775 111071 0 None - 0 Human 4.3 pEC50 = 4.3 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 492 8 2 6 5.0 COc1ccccc1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
53245571 99175 1 None - 0 Human 5.2 pEC50 = 5.2 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 448 6 0 7 4.6 COc1cc2nc(C3CCCC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL2431121 99175 1 None - 0 Human 5.2 pEC50 = 5.2 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 448 6 0 7 4.6 COc1cc2nc(C3CCCC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
118617599 178616 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 450 7 1 6 4.5 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N(C)CCO)c(F)c23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4468696 178616 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 450 7 1 6 4.5 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N(C)CCO)c(F)c23)CC1 10.1021/acs.jmedchem.9b00340
1230852 43116 3 None - 0 Human 5.2 pEC50 = 5.2 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 434 6 0 7 4.3 COc1cc2nc(C3CCC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL1446377 43116 3 None - 0 Human 5.2 pEC50 = 5.2 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 434 6 0 7 4.3 COc1cc2nc(C3CCC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
118617901 181180 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 466 7 1 6 5.0 COc1ccccc1C1CCN(c2nc(C3CC3)nc3cc(Cl)c(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4552414 181180 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 466 7 1 6 5.0 COc1ccccc1C1CCN(c2nc(C3CC3)nc3cc(Cl)c(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
49837912 111069 3 None - 1 Human 5.2 pEC50 = 5.2 Binding
Agonist activity at NTR1 (unknown origin) expressed in CHO-K1 cells coexpressing beta-arrestin/N-terminal deletion mutant of beta-galactosidase fusion protein by chemiluminescence assayAgonist activity at NTR1 (unknown origin) expressed in CHO-K1 cells coexpressing beta-arrestin/N-terminal deletion mutant of beta-galactosidase fusion protein by chemiluminescence assay
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
CHEMBL3099773 111069 3 None - 1 Human 5.2 pEC50 = 5.2 Binding
Agonist activity at NTR1 (unknown origin) expressed in CHO-K1 cells coexpressing beta-arrestin/N-terminal deletion mutant of beta-galactosidase fusion protein by chemiluminescence assayAgonist activity at NTR1 (unknown origin) expressed in CHO-K1 cells coexpressing beta-arrestin/N-terminal deletion mutant of beta-galactosidase fusion protein by chemiluminescence assay
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
56593290 99183 1 None - 0 Human 5.2 pEC50 = 5.2 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 434 7 0 7 4.3 CCOc1ccccc1N1CCN(c2nc(C3CC3)nc3cc(OC)c(OC)cc23)CC1 10.1021/ml400176n
CHEMBL2431130 99183 1 None - 0 Human 5.2 pEC50 = 5.2 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 434 7 0 7 4.3 CCOc1ccccc1N1CCN(c2nc(C3CC3)nc3cc(OC)c(OC)cc23)CC1 10.1021/ml400176n
73356947 99167 0 None - 0 Human 4.2 pEC50 = 4.2 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 468 6 0 6 5.6 CCOc1cc2c(N3CCN(c4c(C)cccc4C)CC3)nc(-c3ccccc3)nc2cc1OC 10.1021/ml400176n
CHEMBL2431111 99167 0 None - 0 Human 4.2 pEC50 = 4.2 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 468 6 0 6 5.6 CCOc1cc2c(N3CCN(c4c(C)cccc4C)CC3)nc(-c3ccccc3)nc2cc1OC 10.1021/ml400176n
118617789 177606 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 458 6 0 6 5.1 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N4CC[C@@H](OC)C4)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4453565 177606 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 458 6 0 6 5.1 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N4CC[C@@H](OC)C4)cc23)CC1 10.1021/acs.jmedchem.9b00340
49837921 111074 0 None - 0 Human 4.2 pEC50 = 4.2 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 438 9 2 7 3.2 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1ccncc1 10.1016/j.bmcl.2013.11.026
CHEMBL3099780 111074 0 None - 0 Human 4.2 pEC50 = 4.2 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 438 9 2 7 3.2 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1ccncc1 10.1016/j.bmcl.2013.11.026
155283653 178070 0 None - 0 Human 5.2 pEC50 = 5.2 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 416 6 0 5 5.4 CCN(C)c1cccc2nc(C3CC3)nc(N3CCC(c4ccccc4OC)CC3)c12 10.1021/acs.jmedchem.9b00340
CHEMBL4460691 178070 0 None - 0 Human 5.2 pEC50 = 5.2 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 416 6 0 5 5.4 CCN(C)c1cccc2nc(C3CC3)nc(N3CCC(c4ccccc4OC)CC3)c12 10.1021/acs.jmedchem.9b00340
118610404 181270 0 None - 0 Human 5.2 pEC50 = 5.2 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 458 5 1 6 4.9 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N4CCC(O)CC4)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4554583 181270 0 None - 0 Human 5.2 pEC50 = 5.2 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 458 5 1 6 4.9 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N4CCC(O)CC4)cc23)CC1 10.1021/acs.jmedchem.9b00340
56593279 99166 0 None - 0 Human 4.2 pEC50 = 4.2 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 448 6 0 7 3.5 COc1cc2nc(C3CC3)nc(N3CCN(C(=O)c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL2431109 99166 0 None - 0 Human 4.2 pEC50 = 4.2 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 448 6 0 7 3.5 COc1cc2nc(C3CC3)nc(N3CCN(C(=O)c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
56593273 99173 1 None - 0 Human 5.2 pEC50 = 5.2 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 406 6 0 7 3.6 C=Cc1nc(N2CCN(c3ccccc3OC)CC2)c2cc(OC)c(OC)cc2n1 10.1021/ml400176n
CHEMBL2431119 99173 1 None - 0 Human 5.2 pEC50 = 5.2 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 406 6 0 7 3.6 C=Cc1nc(N2CCN(c3ccccc3OC)CC2)c2cc(OC)c(OC)cc2n1 10.1021/ml400176n
90237466 181401 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 403 5 0 6 3.9 COc1ccccc1N1CCN(c2nc(C3CC3)nc3ccc(N(C)C)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4557702 181401 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 403 5 0 6 3.9 COc1ccccc1N1CCN(c2nc(C3CC3)nc3ccc(N(C)C)cc23)CC1 10.1021/acs.jmedchem.9b00340
49837919 111072 0 None - 0 Human 4.1 pEC50 = 4.1 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 462 7 2 5 5.0 CC(C)C[C@H](NC(=O)c1cn(-c2ccnc3cc(Cl)ccc23)c(-c2ccccc2)n1)C(=O)O 10.1016/j.bmcl.2013.11.026
CHEMBL3099776 111072 0 None - 0 Human 4.1 pEC50 = 4.1 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 462 7 2 5 5.0 CC(C)C[C@H](NC(=O)c1cn(-c2ccnc3cc(Cl)ccc23)c(-c2ccccc2)n1)C(=O)O 10.1016/j.bmcl.2013.11.026
90237332 181544 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 430 7 0 5 5.7 CCCN(C)c1ccc2nc(C3CC3)nc(N3CCC(c4ccccc4OC)CC3)c2c1 10.1021/acs.jmedchem.9b00340
CHEMBL4561093 181544 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 430 7 0 5 5.7 CCCN(C)c1ccc2nc(C3CC3)nc(N3CCC(c4ccccc4OC)CC3)c2c1 10.1021/acs.jmedchem.9b00340
44157038 195718 16 None 1 3 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1cc(C(=O)N[C@@H](CC(C)C)C(=O)O)nn1-c1ccnc2cc(Cl)ccc12 10.1021/ml400176n
CHEMBL508044 195718 16 None 1 3 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1cc(C(=O)N[C@@H](CC(C)C)C(=O)O)nn1-c1ccnc2cc(Cl)ccc12 10.1021/ml400176n
44157038 195718 16 None 1 3 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1cc(C(=O)N[C@@H](CC(C)C)C(=O)O)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
CHEMBL508044 195718 16 None 1 3 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1cc(C(=O)N[C@@H](CC(C)C)C(=O)O)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
73352405 99247 0 None - 0 Human 4.1 pEC50 = 4.1 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 485 7 0 8 4.9 CCOc1cc2c(N3CCN(c4ccccc4[N+](=O)[O-])CC3)nc(-c3ccccc3)nc2cc1OC 10.1021/ml400176n
CHEMBL2431235 99247 0 None - 0 Human 4.1 pEC50 = 4.1 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 485 7 0 8 4.9 CCOc1cc2c(N3CCN(c4ccccc4[N+](=O)[O-])CC3)nc(-c3ccccc3)nc2cc1OC 10.1021/ml400176n
54758539 99171 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 422 6 0 7 4.1 COc1cc2nc(C(C)C)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
CHEMBL2431117 99171 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assayAgonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay
ChEMBL 422 6 0 7 4.1 COc1cc2nc(C(C)C)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC 10.1021/ml400176n
118610260 177514 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 458 6 0 6 5.1 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N4CC[C@H](OC)C4)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4452254 177514 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 458 6 0 6 5.1 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N4CC[C@H](OC)C4)cc23)CC1 10.1021/acs.jmedchem.9b00340
90237274 179048 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 501 8 0 7 4.7 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N(C)CCN4CCOCC4)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4474616 179048 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 501 8 0 7 4.7 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N(C)CCN4CCOCC4)cc23)CC1 10.1021/acs.jmedchem.9b00340
90237040 180186 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 402 5 0 5 5.0 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N(C)C)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4528434 180186 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 402 5 0 5 5.0 COc1ccccc1C1CCN(c2nc(C3CC3)nc3ccc(N(C)C)cc23)CC1 10.1021/acs.jmedchem.9b00340
118610314 178039 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 420 5 0 5 5.0 COc1ccccc1C1CCN(c2nc(C3(F)CC3)nc3ccc(N(C)C)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4460206 178039 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 420 5 0 5 5.0 COc1ccccc1C1CCN(c2nc(C3(F)CC3)nc3ccc(N(C)C)cc23)CC1 10.1021/acs.jmedchem.9b00340
50898052 111065 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 490 7 2 5 5.6 Cc1cccc(C)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
CHEMBL3099768 111065 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 490 7 2 5 5.6 Cc1cccc(C)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
53495081 111070 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1nc(C(=O)N[C@H](CC(C)C)C(=O)O)cn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
CHEMBL3099774 111070 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1nc(C(=O)N[C@H](CC(C)C)C(=O)O)cn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
76324673 111068 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 492 8 2 6 5.0 COc1ccccc1-c1cc(C(=O)N[C@H](CC(C)C)C(=O)O)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
CHEMBL3099772 111068 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assayAgonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay
ChEMBL 492 8 2 6 5.0 COc1ccccc1-c1cc(C(=O)N[C@H](CC(C)C)C(=O)O)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
118617810 182520 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 446 7 1 6 4.5 COc1ccccc1C1CCN(c2nc(C3(C)CC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
CHEMBL4583177 182520 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 446 7 1 6 4.5 COc1ccccc1C1CCN(c2nc(C3(C)CC3)nc3ccc(N(C)CCO)cc23)CC1 10.1021/acs.jmedchem.9b00340
118617765 181695 0 None - 0 Human 6.0 pEC50 = 6 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 444 7 0 5 6.1 CCCN(C)c1cc2c(N3CCC(c4ccccc4OC)CC3)nc(C3CC3)nc2cc1C 10.1021/acs.jmedchem.9b00340
CHEMBL4564639 181695 0 None - 0 Human 6.0 pEC50 = 6 Binding
Allosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assayAllosteric modulation of human GFP-fused PK-tagged Gq-coupled NTR1 expressed in CHOK1 cells assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment measured after 90 mins by pathhunter assay
ChEMBL 444 7 0 5 6.1 CCCN(C)c1cc2c(N3CCC(c4ccccc4OC)CC3)nc(C3CC3)nc2cc1C 10.1021/acs.jmedchem.9b00340
CHEMBL3622802 218660 0 None - 0 Human 10.7 pIC50 = 10.7 Binding
Displacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](C[Si](C)(C)C)C(=O)O 10.1021/acs.jmedchem.5b00841
CHEMBL258221 217295 17 None 2 2 Human 10.1 pIC50 = 10.1 Binding
Inhibition of human NTR1Inhibition of human NTR1
ChEMBL None None None None 10.1016/j.bmcl.2022.128983
CHEMBL2369722 216438 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)C(CNCCN)CNCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm060415g
1574 9585 20 None -5 6 Human 9.8 pIC50 = 9.8 Binding
Inhibition of human NTR1Inhibition of human NTR1
ChEMBL None None None None 10.1016/j.bmcl.2022.128983
1579 9585 20 None -5 6 Human 9.8 pIC50 = 9.8 Binding
Inhibition of human NTR1Inhibition of human NTR1
ChEMBL None None None None 10.1016/j.bmcl.2022.128983
25077406 9585 20 None -5 6 Human 9.8 pIC50 = 9.8 Binding
Inhibition of human NTR1Inhibition of human NTR1
ChEMBL None None None None 10.1016/j.bmcl.2022.128983
3830 9585 20 None -5 6 Human 9.8 pIC50 = 9.8 Binding
Inhibition of human NTR1Inhibition of human NTR1
ChEMBL None None None None 10.1016/j.bmcl.2022.128983
CHEMBL407196 9585 20 None -5 6 Human 9.8 pIC50 = 9.8 Binding
Inhibition of human NTR1Inhibition of human NTR1
ChEMBL None None None None 10.1016/j.bmcl.2022.128983
56661177 70032 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cells
ChEMBL 1018 37 15 15 -3.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NCC(CCCCN)NC(=O)CNC(=O)C(CNCCN)CNCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm060415g
CHEMBL1791383 70032 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cells
ChEMBL 1018 37 15 15 -3.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NCC(CCCCN)NC(=O)CNC(=O)C(CNCCN)CNCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm060415g
1574 9585 20 None -5 6 Human 9.7 pIC50 = 9.7 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None None 10.1021/jm030081k
1579 9585 20 None -5 6 Human 9.7 pIC50 = 9.7 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None None 10.1021/jm030081k
25077406 9585 20 None -5 6 Human 9.7 pIC50 = 9.7 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None None 10.1021/jm030081k
3830 9585 20 None -5 6 Human 9.7 pIC50 = 9.7 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None None 10.1021/jm030081k
CHEMBL407196 9585 20 None -5 6 Human 9.7 pIC50 = 9.7 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None None 10.1021/jm030081k
1574 9585 20 None -5 6 Human 9.6 pIC50 = 9.6 Binding
Binding affinity to NTS1 receptor (unknown origin) by radioligand displacement assayBinding affinity to NTS1 receptor (unknown origin) by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2013.03.016
1579 9585 20 None -5 6 Human 9.6 pIC50 = 9.6 Binding
Binding affinity to NTS1 receptor (unknown origin) by radioligand displacement assayBinding affinity to NTS1 receptor (unknown origin) by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2013.03.016
25077406 9585 20 None -5 6 Human 9.6 pIC50 = 9.6 Binding
Binding affinity to NTS1 receptor (unknown origin) by radioligand displacement assayBinding affinity to NTS1 receptor (unknown origin) by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2013.03.016
3830 9585 20 None -5 6 Human 9.6 pIC50 = 9.6 Binding
Binding affinity to NTS1 receptor (unknown origin) by radioligand displacement assayBinding affinity to NTS1 receptor (unknown origin) by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2013.03.016
CHEMBL407196 9585 20 None -5 6 Human 9.6 pIC50 = 9.6 Binding
Binding affinity to NTS1 receptor (unknown origin) by radioligand displacement assayBinding affinity to NTS1 receptor (unknown origin) by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2013.03.016
1580 10437 46 None 1 4 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-neurotensin from NTR1 (unknown origin)Displacement of [125I]-neurotensin from NTR1 (unknown origin)
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2013.11.026
5311451 10437 46 None 1 4 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-neurotensin from NTR1 (unknown origin)Displacement of [125I]-neurotensin from NTR1 (unknown origin)
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2013.11.026
CHEMBL3040381 10437 46 None 1 4 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-neurotensin from NTR1 (unknown origin)Displacement of [125I]-neurotensin from NTR1 (unknown origin)
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2013.11.026
1580 10437 46 None 1 4 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-neurotensin from NTR1 in HUVEC after 1 hr by gamma counting analysisDisplacement of [125I]-neurotensin from NTR1 in HUVEC after 1 hr by gamma counting analysis
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/ml400176n
5311451 10437 46 None 1 4 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-neurotensin from NTR1 in HUVEC after 1 hr by gamma counting analysisDisplacement of [125I]-neurotensin from NTR1 in HUVEC after 1 hr by gamma counting analysis
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/ml400176n
CHEMBL3040381 10437 46 None 1 4 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-neurotensin from NTR1 in HUVEC after 1 hr by gamma counting analysisDisplacement of [125I]-neurotensin from NTR1 in HUVEC after 1 hr by gamma counting analysis
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/ml400176n
44354303 30230 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 788 23 10 11 -0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL133340 30230 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 788 23 10 11 -0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
72548703 168346 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 receptor after 120 mins by scintillation counting analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 receptor after 120 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
CHEMBL4128926 168346 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 receptor after 120 mins by scintillation counting analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 receptor after 120 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
CHEMBL336836 218367 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL None None None CCNC(=N)NCCC[C@H](N)C(=O)/N=C(/N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/jm0300633
44354113 30868 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 831 25 9 11 0.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL133850 30868 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 831 25 9 11 0.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL408127 219481 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCC(CN)CC1)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C1CCN(C(=N)N)CC1)C(C)(C)C)C(=O)O 10.1021/jm030081k
CHEMBL408381 219490 1 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C1CCNCC1)C1CCN(C(=N)N)CC1)C(C)(C)C)C(=O)O 10.1021/jm030081k
44354087 29254 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 845 24 12 13 -1.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCNC1NCCN1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL132524 29254 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 845 24 12 13 -1.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCNC1NCCN1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
44354245 174626 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 788 23 10 11 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL430910 174626 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 788 23 10 11 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
44354244 175104 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 831 23 11 11 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCC/N=C(/N)NC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL434227 175104 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 831 23 11 11 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCC/N=C(/N)NC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL342252 218452 0 None -4 4 Human 9.5 pIC50 = 9.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL2369722 216438 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)C(CNCCN)CNCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm060415g
1574 9585 20 None -5 6 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to human NTS1 receptor by radioligand displacement assayBinding affinity to human NTS1 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
1579 9585 20 None -5 6 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to human NTS1 receptor by radioligand displacement assayBinding affinity to human NTS1 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
25077406 9585 20 None -5 6 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to human NTS1 receptor by radioligand displacement assayBinding affinity to human NTS1 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
3830 9585 20 None -5 6 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to human NTS1 receptor by radioligand displacement assayBinding affinity to human NTS1 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
CHEMBL407196 9585 20 None -5 6 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to human NTS1 receptor by radioligand displacement assayBinding affinity to human NTS1 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
CHEMBL258221 217295 17 None 2 2 Human 9.5 pIC50 = 9.5 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptorDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor
ChEMBL None None None None 10.1021/acs.jmedchem.6b01848
44354154 26307 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 818 23 10 10 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL129953 26307 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 818 23 10 10 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
44354212 123479 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 803 24 10 11 -0.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL337260 123479 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 803 24 10 11 -0.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
44354302 30283 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 803 23 9 11 -0.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL133378 30283 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 803 23 9 11 -0.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
44354075 123544 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 803 24 10 11 -0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL337644 123544 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 803 24 10 11 -0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL468951 220805 0 None - 1 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
CHEMBL2370478 216632 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)c1ccc(NC(=N)N)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm030081k
CHEMBL404942 219314 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC(C)(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C1CCN(C(=N)N)CC1)C(C)(C)C)C(=O)O 10.1021/jm030081k
CHEMBL408638 219504 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C1CCN(C(=N)N)CC1)C(C)(C)C)C(=O)O 10.1021/jm030081k
CHEMBL409477 219545 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm030081k
44354120 29117 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 816 23 11 11 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL132409 29117 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 816 23 11 11 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
44354085 29237 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 817 24 9 11 0.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL132507 29237 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 817 24 9 11 0.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCN(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL439494 220621 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL None None None None 10.1021/jm0300633
1569 8907 32 None 2 2 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
5311318 8907 32 None 2 2 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
CHEMBL415788 8907 32 None 2 2 Human 9.4 pIC50 = 9.4 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
56661177 70032 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cells
ChEMBL 1018 37 15 15 -3.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NCC(CCCCN)NC(=O)CNC(=O)C(CNCCN)CNCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm060415g
CHEMBL1791383 70032 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cells
ChEMBL 1018 37 15 15 -3.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NCC(CCCCN)NC(=O)CNC(=O)C(CNCCN)CNCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm060415g
1574 9585 20 None -5 6 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cells
ChEMBL None None None None 10.1021/jm060415g
1579 9585 20 None -5 6 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cells
ChEMBL None None None None 10.1021/jm060415g
25077406 9585 20 None -5 6 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cells
ChEMBL None None None None 10.1021/jm060415g
3830 9585 20 None -5 6 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cells
ChEMBL None None None None 10.1021/jm060415g
CHEMBL407196 9585 20 None -5 6 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cells
ChEMBL None None None None 10.1021/jm060415g
1574 9585 20 None -5 6 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NT1 receptor expressed in CHO cellsDisplacement of [125I]Tyr3-neurotensin from human recombinant NT1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
1579 9585 20 None -5 6 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NT1 receptor expressed in CHO cellsDisplacement of [125I]Tyr3-neurotensin from human recombinant NT1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
25077406 9585 20 None -5 6 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NT1 receptor expressed in CHO cellsDisplacement of [125I]Tyr3-neurotensin from human recombinant NT1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
3830 9585 20 None -5 6 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NT1 receptor expressed in CHO cellsDisplacement of [125I]Tyr3-neurotensin from human recombinant NT1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
CHEMBL407196 9585 20 None -5 6 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NT1 receptor expressed in CHO cellsDisplacement of [125I]Tyr3-neurotensin from human recombinant NT1 receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
1574 9585 20 None -5 6 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
1579 9585 20 None -5 6 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
25077406 9585 20 None -5 6 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
3830 9585 20 None -5 6 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
CHEMBL407196 9585 20 None -5 6 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
90663196 113394 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL 1499 27 18 18 3.2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)C1OC2(c3ccc(O)cc3OC3C=C(O)C=CC32)c2ccc(NC(=N)S)cc21)C1CCNCC1)C1CCC(C(=N)N)CC1)C(C)(C)C)C(=O)O 10.1021/jm030081k
CHEMBL3142915 113394 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL 1499 27 18 18 3.2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)C1OC2(c3ccc(O)cc3OC3C=C(O)C=CC32)c2ccc(NC(=N)S)cc21)C1CCNCC1)C1CCC(C(=N)N)CC1)C(C)(C)C)C(=O)O 10.1021/jm030081k
CHEMBL2369628 216422 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(NC(=N)N)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm030081k
44413847 143989 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cells
ChEMBL 1046 35 16 15 -4.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NCC(CCCN=C(N)N)NC(=O)CNC(=O)C(CNCCN)CNCCN)C(C)(C)C)C(=O)O 10.1021/jm060415g
CHEMBL375002 143989 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cells
ChEMBL 1046 35 16 15 -4.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NCC(CCCN=C(N)N)NC(=O)CNC(=O)C(CNCCN)CNCCN)C(C)(C)C)C(=O)O 10.1021/jm060415g
44354211 29555 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 846 25 10 10 0.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCCCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL132794 29555 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 846 25 10 10 0.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCCCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
44354112 30867 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 817 25 10 11 0.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL133849 30867 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 817 25 10 11 0.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCNC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
44354304 123833 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 774 22 10 11 -0.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL339139 123833 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 774 22 10 11 -0.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
122197319 140237 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL 1485 32 18 18 3.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCNC(=O)C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(NC(=N)S)cc21)C1CCC(C(=N)N)CC1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm030081k
CHEMBL3706654 140237 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL 1485 32 18 18 3.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCNC(=O)C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(NC(=N)S)cc21)C1CCC(C(=N)N)CC1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm030081k
CHEMBL2369133 216373 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C1CCN(C(=N)N)CC1)C(C)(C)C)C(=O)O 10.1021/jm030081k
CHEMBL386387 219160 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC(C)(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C1CCN(C(=N)N)CC1)C(=O)N[C@@H](CC1CCCCC1)C(=O)O 10.1021/jm030081k
1574 9585 20 None -5 6 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cells
ChEMBL None None None None 10.1021/jm060415g
1579 9585 20 None -5 6 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cells
ChEMBL None None None None 10.1021/jm060415g
25077406 9585 20 None -5 6 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cells
ChEMBL None None None None 10.1021/jm060415g
3830 9585 20 None -5 6 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cells
ChEMBL None None None None 10.1021/jm060415g
CHEMBL407196 9585 20 None -5 6 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cells
ChEMBL None None None None 10.1021/jm060415g
44413846 90221 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cells
ChEMBL 1018 35 15 15 -3.0 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NCC(CCCCN)NC(=O)CNC(=O)C(CNCCN)CNCCN)C(C)(C)C)C(=O)O 10.1021/jm060415g
CHEMBL219862 90221 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in WiDr cells
ChEMBL 1018 35 15 15 -3.0 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NCC(CCCCN)NC(=O)CNC(=O)C(CNCCN)CNCCN)C(C)(C)C)C(=O)O 10.1021/jm060415g
1569 8907 32 None 2 2 Human 9.1 pIC50 = 9.1 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL None None None None 10.1021/acsmedchemlett.7b00500
5311318 8907 32 None 2 2 Human 9.1 pIC50 = 9.1 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL None None None None 10.1021/acsmedchemlett.7b00500
CHEMBL415788 8907 32 None 2 2 Human 9.1 pIC50 = 9.1 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL None None None None 10.1021/acsmedchemlett.7b00500
1569 8907 32 None 2 2 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b00841
5311318 8907 32 None 2 2 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b00841
CHEMBL415788 8907 32 None 2 2 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b00841
44413847 143989 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cells
ChEMBL 1046 35 16 15 -4.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NCC(CCCN=C(N)N)NC(=O)CNC(=O)C(CNCCN)CNCCN)C(C)(C)C)C(=O)O 10.1021/jm060415g
CHEMBL375002 143989 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cells
ChEMBL 1046 35 16 15 -4.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NCC(CCCN=C(N)N)NC(=O)CNC(=O)C(CNCCN)CNCCN)C(C)(C)C)C(=O)O 10.1021/jm060415g
CHEMBL504768 220963 0 None - 1 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)N=[N+]=[N-])C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
119192 9259 54 None -3 9 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm801072v
1582 9259 54 None -3 9 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm801072v
CHEMBL506981 9259 54 None -3 9 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm801072v
DB06455 9259 54 None -3 9 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm801072v
CHEMBL1086462 215275 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [3H]neurotensin from NTR1 in human HT29 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]neurotensin from NTR1 in human HT29 cells after 30 mins by liquid scintillation spectrometry
ChEMBL None None None None 10.1016/j.bmcl.2010.04.038
122197320 140238 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL 1485 32 18 18 3.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(NC(N)=S)cc21)C1CCC(C(=N)N)CC1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm030081k
CHEMBL3706655 140238 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL 1485 32 18 18 3.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(NC(N)=S)cc21)C1CCC(C(=N)N)CC1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm030081k
44354086 123557 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 843 23 10 13 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN1CCN=C1N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL337721 123557 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 843 23 10 13 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCN1CCN=C1N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL138970 215536 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Compound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cellsCompound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)[C@@H](N)CCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/s0960-894x(00)00018-4
127032102 145976 0 None 1 2 Human 8.9 pIC50 = 8.9 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 931 28 14 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786852 145976 0 None 1 2 Human 8.9 pIC50 = 8.9 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 931 28 14 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787704 145976 0 None 1 2 Human 8.9 pIC50 = 8.9 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 931 28 14 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
127032412 145978 0 None 4 2 Human 8.9 pIC50 = 8.9 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3785364 145978 0 None 4 2 Human 8.9 pIC50 = 8.9 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3786291 145978 0 None 4 2 Human 8.9 pIC50 = 8.9 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3787706 145978 0 None 4 2 Human 8.9 pIC50 = 8.9 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL4579623 145978 0 None 4 2 Human 8.9 pIC50 = 8.9 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL342252 218452 0 None -4 4 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
1574 9585 20 None -5 6 Human 8.9 pIC50 = 8.9 Binding
Inhibition of human NTS1 receptorInhibition of human NTS1 receptor
ChEMBL None None None None 10.1021/jm701575k
1579 9585 20 None -5 6 Human 8.9 pIC50 = 8.9 Binding
Inhibition of human NTS1 receptorInhibition of human NTS1 receptor
ChEMBL None None None None 10.1021/jm701575k
25077406 9585 20 None -5 6 Human 8.9 pIC50 = 8.9 Binding
Inhibition of human NTS1 receptorInhibition of human NTS1 receptor
ChEMBL None None None None 10.1021/jm701575k
3830 9585 20 None -5 6 Human 8.9 pIC50 = 8.9 Binding
Inhibition of human NTS1 receptorInhibition of human NTS1 receptor
ChEMBL None None None None 10.1021/jm701575k
CHEMBL407196 9585 20 None -5 6 Human 8.9 pIC50 = 8.9 Binding
Inhibition of human NTS1 receptorInhibition of human NTS1 receptor
ChEMBL None None None None 10.1021/jm701575k
CHEMBL437707 220509 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C1CCN(C(=N)N)CC1)C(C)(C)C)C(=O)O 10.1021/jm030081k
44413846 90221 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cells
ChEMBL 1018 35 15 15 -3.0 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NCC(CCCCN)NC(=O)CNC(=O)C(CNCCN)CNCCN)C(C)(C)C)C(=O)O 10.1021/jm060415g
CHEMBL219862 90221 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cellsDisplacement of [125I]Tyr3-NT from human NTS1R expressed in HT29 cells
ChEMBL 1018 35 15 15 -3.0 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NCC(CCCCN)NC(=O)CNC(=O)C(CNCCN)CNCCN)C(C)(C)C)C(=O)O 10.1021/jm060415g
44354305 30786 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 832 24 10 10 0.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
CHEMBL133798 30786 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 832 24 10 10 0.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)NC(=O)[C@@H](N)CCCC[N+](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm0300633
127033029 145983 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 1047 34 14 13 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3786771 145983 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 1047 34 14 13 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3787711 145983 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 1047 34 14 13 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
1574 9585 20 None -5 6 Human 8.7 pIC50 = 8.7 Binding
Displacement of radiolabeled neurotensin from human neurotensin receptor 1Displacement of radiolabeled neurotensin from human neurotensin receptor 1
ChEMBL None None None None 10.1021/jm8007618
1579 9585 20 None -5 6 Human 8.7 pIC50 = 8.7 Binding
Displacement of radiolabeled neurotensin from human neurotensin receptor 1Displacement of radiolabeled neurotensin from human neurotensin receptor 1
ChEMBL None None None None 10.1021/jm8007618
25077406 9585 20 None -5 6 Human 8.7 pIC50 = 8.7 Binding
Displacement of radiolabeled neurotensin from human neurotensin receptor 1Displacement of radiolabeled neurotensin from human neurotensin receptor 1
ChEMBL None None None None 10.1021/jm8007618
3830 9585 20 None -5 6 Human 8.7 pIC50 = 8.7 Binding
Displacement of radiolabeled neurotensin from human neurotensin receptor 1Displacement of radiolabeled neurotensin from human neurotensin receptor 1
ChEMBL None None None None 10.1021/jm8007618
CHEMBL407196 9585 20 None -5 6 Human 8.7 pIC50 = 8.7 Binding
Displacement of radiolabeled neurotensin from human neurotensin receptor 1Displacement of radiolabeled neurotensin from human neurotensin receptor 1
ChEMBL None None None None 10.1021/jm8007618
CHEMBL342252 218452 0 None - 4 Rat 8.0 pIC50 = 8 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracer
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm00006a021
CHEMBL2369627 216421 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCc1ccnc(N)n1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm030081k
44572617 195576 0 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 803 23 11 10 0.2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@H](N)CCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL505906 195576 0 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 803 23 11 10 0.2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@H](N)CCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
145990648 173699 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 685 11 8 9 -0.2 CC(C)C[C@H](NC(=O)[C@@H]1CC=CC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)O 10.1021/acsmedchemlett.7b00500
CHEMBL4286652 173699 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 685 11 8 9 -0.2 CC(C)C[C@H](NC(=O)[C@@H]1CC=CC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)O 10.1021/acsmedchemlett.7b00500
90663479 113462 0 None - 0 Rat 5.0 pIC50 = 5 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT (neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT (neurotensin) as tracer
ChEMBL 828 25 11 11 -1.2 CC[C@H](C)[C@H](NC(C#N)[C@H](Cc1ccc(O)cc1)NC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm00006a021
CHEMBL3143475 113462 0 None - 0 Rat 5.0 pIC50 = 5 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT (neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT (neurotensin) as tracer
ChEMBL 828 25 11 11 -1.2 CC[C@H](C)[C@H](NC(C#N)[C@H](Cc1ccc(O)cc1)NC(=O)C1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm00006a021
145994034 174104 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 771 15 8 10 0.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)CC=CCOC[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.7b00500
CHEMBL4294207 174104 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 771 15 8 10 0.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)CC=CCOC[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.7b00500
CHEMBL2370479 216633 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1cccc(O)c1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C1CCN(C(=N)N)CC1)C(C)(C)C)C(=O)O 10.1021/jm030081k
CHEMBL405160 219325 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCN1C(=O)[C@@H](CCCCN)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C1CCN(C(=N)N)CC1)C(C)(C)C)C(=O)O 10.1021/jm030081k
CHEMBL407187 219423 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC(C)(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C1CCN(C(=N)N)CC1)C(=O)N[C@@H](CC1CCCCC1)C(=O)O 10.1021/jm030081k
CHEMBL410289 219590 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C1CCN(C(=N)N)CC1)C(C)(C)C)C(=O)O 10.1021/jm030081k
CHEMBL3143232 217919 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracer
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)C[C@H](Cc1ccccc1)C(=O)O 10.1021/jm00006a021
10079267 113450 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracer
ChEMBL 849 25 12 10 0.2 CC(C)C[C@H](NC(=O)[C@H](CC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)Cc1ccccc1)C(=O)O 10.1021/jm00006a021
CHEMBL3143334 113450 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracer
ChEMBL 849 25 12 10 0.2 CC(C)C[C@H](NC(=O)[C@H](CC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)Cc1ccccc1)C(=O)O 10.1021/jm00006a021
CHEMBL3143232 217919 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracer
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)C[C@H](Cc1ccccc1)C(=O)O 10.1021/jm00006a021
145974670 171417 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 799 13 9 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4216311 171417 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 799 13 9 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
44572621 195032 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 817 23 11 10 0.5 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@](C)(N)CCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL499673 195032 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 817 23 11 10 0.5 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@](C)(N)CCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
145975635 170565 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 826 13 8 9 3.3 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCC[C@](C)(N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4205887 170565 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 826 13 8 9 3.3 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCC[C@](C)(N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
44354121 175264 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 826 22 10 10 0.7 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)NC(=O)[C@@H](N)CCCCCN)C(C)(C)C)C(=O)O 10.1021/jm0300633
CHEMBL435199 175264 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 826 22 10 10 0.7 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)NC(=O)[C@@H](N)CCCCCN)C(C)(C)C)C(=O)O 10.1021/jm0300633
CHEMBL343970 218482 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cellsCompound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNCCN)N=[N+]=[N-])C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/s0960-894x(00)00018-4
CHEMBL508380 221662 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)N=[N+]=[N-])C(C)(C)C)C(=O)O 10.1021/jm801072v
145980057 173302 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 811 28 7 8 4.4 C=CCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)c(CC=C)c1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acsmedchemlett.7b00500
CHEMBL4279055 173302 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 811 28 7 8 4.4 C=CCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)c(CC=C)c1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acsmedchemlett.7b00500
145980071 173323 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 685 11 8 9 -0.2 CC(C)C[C@H](NC(=O)[C@H]1CC=CC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)O 10.1021/acsmedchemlett.7b00500
CHEMBL4279408 173323 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 685 11 8 9 -0.2 CC(C)C[C@H](NC(=O)[C@H]1CC=CC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)O 10.1021/acsmedchemlett.7b00500
10079267 113450 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracer
ChEMBL 849 25 12 10 0.2 CC(C)C[C@H](NC(=O)[C@H](CC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)Cc1ccccc1)C(=O)O 10.1021/jm00006a021
CHEMBL3143334 113450 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracer
ChEMBL 849 25 12 10 0.2 CC(C)C[C@H](NC(=O)[C@H](CC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)Cc1ccccc1)C(=O)O 10.1021/jm00006a021
CHEMBL3622806 218664 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C[Si](C)(C)CN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b00841
CHEMBL3622803 218661 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
ChEMBL None None None C[Si](C)(C)C[C@H](NC(=O)[C@H](C[Si](C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)O 10.1021/acs.jmedchem.5b00841
CHEMBL3143232 217919 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracer
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)C[C@H](Cc1ccccc1)C(=O)O 10.1021/jm00006a021
CHEMBL3622806 218664 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of human NTR1Inhibition of human NTR1
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C[Si](C)(C)CN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmcl.2022.128983
145979804 173519 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 713 22 8 9 0.6 C=CC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC=C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.7b00500
CHEMBL4283301 173519 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 713 22 8 9 0.6 C=CC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC=C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.7b00500
145989581 173950 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 685 11 8 9 -0.2 CC(C)C[C@H](NC(=O)[C@@H]1CC=CC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)O 10.1021/acsmedchemlett.7b00500
CHEMBL4291157 173950 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 685 11 8 9 -0.2 CC(C)C[C@H](NC(=O)[C@@H]1CC=CC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)O 10.1021/acsmedchemlett.7b00500
90663286 113410 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT (neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT (neurotensin) as tracer
ChEMBL 828 25 11 11 -1.2 CC[C@H](C)[C@H](NC(C#N)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm00006a021
CHEMBL3143244 113410 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT (neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT (neurotensin) as tracer
ChEMBL 828 25 11 11 -1.2 CC[C@H](C)[C@H](NC(C#N)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm00006a021
44572618 195760 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 845 24 11 10 0.3 CC(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
CHEMBL508507 195760 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 845 24 11 10 0.3 CC(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
25078013 220855 11 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cellsCompound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(00)00018-4
CHEMBL48981 220855 11 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cellsCompound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(00)00018-4
145989754 173889 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 685 11 8 9 -0.2 CC(C)C[C@H](NC(=O)[C@H]1CC=CC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)O 10.1021/acsmedchemlett.7b00500
CHEMBL4290088 173889 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 685 11 8 9 -0.2 CC(C)C[C@H](NC(=O)[C@H]1CC=CC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)O 10.1021/acsmedchemlett.7b00500
1574 9585 20 None -5 6 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None None 10.1021/jm801072v
1579 9585 20 None -5 6 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None None 10.1021/jm801072v
25077406 9585 20 None -5 6 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None None 10.1021/jm801072v
3830 9585 20 None -5 6 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None None 10.1021/jm801072v
CHEMBL407196 9585 20 None -5 6 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None None 10.1021/jm801072v
CHEMBL344337 218484 0 None -14 2 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
CHEMBL424896 220105 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC1CCN(C(=N)N)CC1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(C)(C)C)C(=O)O 10.1021/jm030081k
44572616 195561 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 801 24 12 9 -0.0 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
CHEMBL505695 195561 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 801 24 12 9 -0.0 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
44413847 143989 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]Tyr3-NT from NTS1R in human exocrine ductal pancreatic carcinomaDisplacement of [125I]Tyr3-NT from NTS1R in human exocrine ductal pancreatic carcinoma
ChEMBL 1046 35 16 15 -4.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NCC(CCCN=C(N)N)NC(=O)CNC(=O)C(CNCCN)CNCCN)C(C)(C)C)C(=O)O 10.1021/jm060415g
CHEMBL375002 143989 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]Tyr3-NT from NTS1R in human exocrine ductal pancreatic carcinomaDisplacement of [125I]Tyr3-NT from NTS1R in human exocrine ductal pancreatic carcinoma
ChEMBL 1046 35 16 15 -4.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NCC(CCCN=C(N)N)NC(=O)CNC(=O)C(CNCCN)CNCCN)C(C)(C)C)C(=O)O 10.1021/jm060415g
CHEMBL405804 219361 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None COC(=O)[C@H](CC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C1CCN(C(=N)N)CC1)C(C)(C)C 10.1021/jm030081k
CHEMBL2369629 216423 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(NC(=N)N)cc1)NC(=O)[C@H](Cc1ccc(NC(=N)N)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm030081k
CHEMBL2370477 216631 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(NC(=N)N)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(C)(C)C)C(=O)O 10.1021/jm030081k
CHEMBL266571 217468 2 None -2041 2 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
CHEMBL3622805 218663 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
ChEMBL None None None CN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C[Si](C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b00841
145966776 171215 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 782 13 7 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCCC(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4213725 171215 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 782 13 7 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCCC(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
44572619 178997 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 817 24 11 10 0.4 CN[C@@H](CCCCN)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
CHEMBL447400 178997 0 None - 1 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 817 24 11 10 0.4 CN[C@@H](CCCCN)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
CHEMBL141910 215545 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Compound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cellsCompound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNCCN1CCNCC1)N=[N+]=[N-])C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/s0960-894x(00)00018-4
CHEMBL501956 220926 0 None - 1 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@](C)(N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/jm801072v
145990573 173596 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 658 12 7 9 0.1 CC(C)C[C@H](NC(=O)[C@@H]1COCC=CCc2cc(ccc2O)C[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCCN)C(=O)N1)C(=O)O 10.1021/acsmedchemlett.7b00500
CHEMBL4284772 173596 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 658 12 7 9 0.1 CC(C)C[C@H](NC(=O)[C@@H]1COCC=CCc2cc(ccc2O)C[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CCCCN)C(=O)N1)C(=O)O 10.1021/acsmedchemlett.7b00500
1580 10437 46 None 1 4 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/acs.jmedchem.5b01495
5311451 10437 46 None 1 4 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/acs.jmedchem.5b01495
CHEMBL3040381 10437 46 None 1 4 Human 8.5 pIC50 = 8.5 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/acs.jmedchem.5b01495
122197318 140236 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL 1903 35 23 23 7.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(NC(=N)S)cc21)NC(=O)C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(NC(=N)S)cc21)C1CCC(C(=N)N)CC1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm030081k
CHEMBL3706653 140236 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL 1903 35 23 23 7.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(NC(=N)S)cc21)NC(=O)C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(NC(=N)S)cc21)C1CCC(C(=N)N)CC1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm030081k
CHEMBL141872 215544 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Compound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cellsCompound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNCCCN)N=[N+]=[N-])C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/s0960-894x(00)00018-4
44572622 179476 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 787 23 10 9 1.2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL450258 179476 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 787 23 10 9 1.2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
1580 10437 46 None 1 4 Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at NTR1 (unknown origin)Antagonist activity at NTR1 (unknown origin)
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/acs.jmedchem.9b00340
5311451 10437 46 None 1 4 Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at NTR1 (unknown origin)Antagonist activity at NTR1 (unknown origin)
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/acs.jmedchem.9b00340
CHEMBL3040381 10437 46 None 1 4 Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at NTR1 (unknown origin)Antagonist activity at NTR1 (unknown origin)
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/acs.jmedchem.9b00340
145989745 173864 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 782 13 7 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)CC=CCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.7b00500
CHEMBL4289739 173864 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 782 13 7 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)CC=CCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.7b00500
CHEMBL445035 220716 0 None - 1 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL413010 219821 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC(C)(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C1CCN(C(=N)N)CC1)C(=O)N[C@@H](CC1CCCC1)C(=O)O 10.1021/jm030081k
9888496 147831 0 None - 0 Rat 4.3 pIC50 = 4.3 Binding
Inhibitory concentration required for the displacement of [3H]NT from neurotensin receptor in ratInhibitory concentration required for the displacement of [3H]NT from neurotensin receptor in rat
ChEMBL 422 7 2 5 2.9 Cc1ccc(S(=O)(=O)NCCNC2(c3ccccc3)OC(=O)c3ccccc32)cc1 10.1016/S0960-894X(00)80423-0
CHEMBL38243 147831 0 None - 0 Rat 4.3 pIC50 = 4.3 Binding
Inhibitory concentration required for the displacement of [3H]NT from neurotensin receptor in ratInhibitory concentration required for the displacement of [3H]NT from neurotensin receptor in rat
ChEMBL 422 7 2 5 2.9 Cc1ccc(S(=O)(=O)NCCNC2(c3ccccc3)OC(=O)c3ccccc32)cc1 10.1016/S0960-894X(00)80423-0
CHEMBL1793839 215706 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracer
ChEMBL None None None CC[C@@H](C)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00006a021
127034293 145980 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 1427 41 14 17 2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787095 145980 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 1427 41 14 17 2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787708 145980 0 None - 1 Human 8.3 pIC50 = 8.3 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 1427 41 14 17 2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
11657884 122977 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 803 22 10 11 -0.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN)C(C)(C)C)C(=O)O 10.1021/jm0300633
CHEMBL335846 122977 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1Evaluated for binding affinity by inhibiting binding of [125I]-Tyr(3)-NT to human Neurotensin receptor 1
ChEMBL 803 22 10 11 -0.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCC/N=C(/N)NC(=O)[C@@H](N)CCCCCN)C(C)(C)C)C(=O)O 10.1021/jm0300633
1580 10437 46 None 1 4 Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin assessed as inhibition of ML314-induced effect by GFP reporter gene assayAntagonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin assessed as inhibition of ML314-induced effect by GFP reporter gene assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/ml400176n
5311451 10437 46 None 1 4 Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin assessed as inhibition of ML314-induced effect by GFP reporter gene assayAntagonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin assessed as inhibition of ML314-induced effect by GFP reporter gene assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/ml400176n
CHEMBL3040381 10437 46 None 1 4 Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin assessed as inhibition of ML314-induced effect by GFP reporter gene assayAntagonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin assessed as inhibition of ML314-induced effect by GFP reporter gene assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/ml400176n
CHEMBL2370480 216634 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C1CCN(C(=N)N)CC1)C1CCNCC1)C(C)(C)C)C(=O)O 10.1021/jm030081k
CHEMBL413192 219833 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptideBinding affinity towards neurotensin receptor in membranes prepared from HT-29 cell line, relative to [111In]-labeled neurotensin peptide
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC1CCN(C(=N)N)CC1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(C)(C)C)C(=O)O 10.1021/jm030081k
CHEMBL501575 220918 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@](C)(N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
155567371 182740 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [177Lu] DOTA-beta-ala-[N-alpha-Me8, Dmt11, Tle12] NT6-13 from neurotensin receptor in human HT-29 cells incubated for 45 mins by gamma counter analysisDisplacement of [177Lu] DOTA-beta-ala-[N-alpha-Me8, Dmt11, Tle12] NT6-13 from neurotensin receptor in human HT-29 cells incubated for 45 mins by gamma counter analysis
ChEMBL 2295 66 31 36 -10.9 Cc1cc(O)cc(C)c1C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@H](Cc1cn(CCNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)C2OC2C(=O)O)nn1)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1016/j.ejmech.2019.05.068
CHEMBL4588311 182740 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [177Lu] DOTA-beta-ala-[N-alpha-Me8, Dmt11, Tle12] NT6-13 from neurotensin receptor in human HT-29 cells incubated for 45 mins by gamma counter analysisDisplacement of [177Lu] DOTA-beta-ala-[N-alpha-Me8, Dmt11, Tle12] NT6-13 from neurotensin receptor in human HT-29 cells incubated for 45 mins by gamma counter analysis
ChEMBL 2295 66 31 36 -10.9 Cc1cc(O)cc(C)c1C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@H](Cc1cn(CCNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)C2OC2C(=O)O)nn1)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1016/j.ejmech.2019.05.068
9888496 147831 0 None - 0 Mouse 5.2 pIC50 = 5.2 Binding
Inhibitory concentration required for the displacement of [3H]NT from neurotensin receptor in mouse; value ranges from 4-6 uMInhibitory concentration required for the displacement of [3H]NT from neurotensin receptor in mouse; value ranges from 4-6 uM
ChEMBL 422 7 2 5 2.9 Cc1ccc(S(=O)(=O)NCCNC2(c3ccccc3)OC(=O)c3ccccc32)cc1 10.1016/S0960-894X(00)80423-0
CHEMBL38243 147831 0 None - 0 Mouse 5.2 pIC50 = 5.2 Binding
Inhibitory concentration required for the displacement of [3H]NT from neurotensin receptor in mouse; value ranges from 4-6 uMInhibitory concentration required for the displacement of [3H]NT from neurotensin receptor in mouse; value ranges from 4-6 uM
ChEMBL 422 7 2 5 2.9 Cc1ccc(S(=O)(=O)NCCNC2(c3ccccc3)OC(=O)c3ccccc32)cc1 10.1016/S0960-894X(00)80423-0
155544586 180174 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [177Lu] DOTA-beta-ala-[N-alpha-Me8, Dmt11, Tle12] NT6-13 from neurotensin receptor in human HT-29 cells incubated for 45 mins by gamma counter analysisDisplacement of [177Lu] DOTA-beta-ala-[N-alpha-Me8, Dmt11, Tle12] NT6-13 from neurotensin receptor in human HT-29 cells incubated for 45 mins by gamma counter analysis
ChEMBL 2281 67 31 35 -9.9 Cc1cc(O)cc(C)c1C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@H](Cc1cn(CCNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)CCC(=O)O)nn1)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1016/j.ejmech.2019.05.068
CHEMBL4528094 180174 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [177Lu] DOTA-beta-ala-[N-alpha-Me8, Dmt11, Tle12] NT6-13 from neurotensin receptor in human HT-29 cells incubated for 45 mins by gamma counter analysisDisplacement of [177Lu] DOTA-beta-ala-[N-alpha-Me8, Dmt11, Tle12] NT6-13 from neurotensin receptor in human HT-29 cells incubated for 45 mins by gamma counter analysis
ChEMBL 2281 67 31 35 -9.9 Cc1cc(O)cc(C)c1C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@H](Cc1cn(CCNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)CCC(=O)O)nn1)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1016/j.ejmech.2019.05.068
56664871 70096 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracer
ChEMBL 803 25 11 10 -1.1 CC[C@@H](C)[C@@H](NC[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm00006a021
CHEMBL1793838 70096 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracer
ChEMBL 803 25 11 10 -1.1 CC[C@@H](C)[C@@H](NC[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm00006a021
44572620 180637 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 828 24 10 10 1.5 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@H](CCCCN)N=[N+]=[N-])C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL453924 180637 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 828 24 10 10 1.5 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@H](CCCCN)N=[N+]=[N-])C(C)(C)C)C(=O)O 10.1021/jm801072v
46890552 14158 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]neurotensin from NTR1 in human HT29 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]neurotensin from NTR1 in human HT29 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 1711 55 22 24 -3.2 CSCC[C@H](NC(=O)CCCCn1cc(CCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O)nn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O 10.1016/j.bmcl.2010.04.038
CHEMBL1086461 14158 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]neurotensin from NTR1 in human HT29 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]neurotensin from NTR1 in human HT29 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 1711 55 22 24 -3.2 CSCC[C@H](NC(=O)CCCCn1cc(CCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O)nn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O 10.1016/j.bmcl.2010.04.038
145991532 173681 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 741 15 8 9 1.0 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)CC=CC[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.7b00500
CHEMBL4286324 173681 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting methodDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHO-K1 cell membranes after 60 mins by gamma-counting method
ChEMBL 741 15 8 9 1.0 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(O)c(c2)CC=CC[C@H](NC(=O)[C@@H](N)CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.7b00500
CHEMBL2371276 216811 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracer
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)O 10.1021/jm00006a021
CHEMBL139727 215538 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cellsCompound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNCCNCCN)N=[N+]=[N-])C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/s0960-894x(00)00018-4
56675175 70095 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracer
ChEMBL 837 25 11 10 -0.9 CC[C@@H](C)[C@H](CN[C@@H](Cc1ccccc1)C(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N 10.1021/jm00006a021
CHEMBL1793837 70095 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracer
ChEMBL 837 25 11 10 -0.9 CC[C@@H](C)[C@H](CN[C@@H](Cc1ccccc1)C(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N 10.1021/jm00006a021
119192 9259 54 None 3 9 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [125I]neurotensin from rat brain NTR1Displacement of [125I]neurotensin from rat brain NTR1
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/acs.jmedchem.9b00340
1582 9259 54 None 3 9 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [125I]neurotensin from rat brain NTR1Displacement of [125I]neurotensin from rat brain NTR1
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/acs.jmedchem.9b00340
CHEMBL506981 9259 54 None 3 9 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [125I]neurotensin from rat brain NTR1Displacement of [125I]neurotensin from rat brain NTR1
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/acs.jmedchem.9b00340
DB06455 9259 54 None 3 9 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [125I]neurotensin from rat brain NTR1Displacement of [125I]neurotensin from rat brain NTR1
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/acs.jmedchem.9b00340
46890553 14159 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]neurotensin from NTR1 in human HT29 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]neurotensin from NTR1 in human HT29 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 1791 57 23 25 -3.1 CSCC[C@H](NC(=O)CCCCn1cc(CCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O)nn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)OP(=O)(O)O 10.1016/j.bmcl.2010.04.038
CHEMBL1086463 14159 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]neurotensin from NTR1 in human HT29 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]neurotensin from NTR1 in human HT29 cells after 30 mins by liquid scintillation spectrometry
ChEMBL 1791 57 23 25 -3.1 CSCC[C@H](NC(=O)CCCCn1cc(CCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O)nn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)OP(=O)(O)O 10.1016/j.bmcl.2010.04.038
44572627 195064 0 None - 1 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 796 22 10 8 1.6 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CCCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL500173 195064 0 None - 1 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 796 22 10 8 1.6 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CCCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL500734 220902 0 None - 1 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
CHEMBL344020 218483 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Compound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cellsCompound was evaluated for the binding affinity against human neurotensin receptor (hNTR)-1 expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNCCCCN)N=[N+]=[N-])C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/s0960-894x(00)00018-4
CHEMBL3143232 217919 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
IC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracerIC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracer
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)C[C@H](Cc1ccccc1)C(=O)O 10.1021/jm00006a021
CHEMBL3622801 218659 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C[Si](C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)O 10.1021/acs.jmedchem.5b00841
CHEMBL3622804 218662 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assayDisplacement of [125I]-Tyr3-NT from human NTS1 receptor expressed in CHOK1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](C[Si](C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1C[Si](C)(C)CN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCCN)C(=O)O 10.1021/acs.jmedchem.5b00841
CHEMBL342252 218452 0 None -4 4 Human 9.8 pKd = 9.8 Binding
In vitro inhibition of [3H]-NT binding to human striatal Neurotensin receptor 1In vitro inhibition of [3H]-NT binding to human striatal Neurotensin receptor 1
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm049644y
127032412 145978 0 None 4 2 Human 9.4 pKd = 9.4 Binding
Binding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting in presence of NTSR2 ligand (S)-2-((2S,3S)-2-(2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)-N-(4-hydroxyphenethyl)pyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acidBinding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting in presence of NTSR2 ligand (S)-2-((2S,3S)-2-(2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)-N-(4-hydroxyphenethyl)pyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acid
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3785364 145978 0 None 4 2 Human 9.4 pKd = 9.4 Binding
Binding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting in presence of NTSR2 ligand (S)-2-((2S,3S)-2-(2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)-N-(4-hydroxyphenethyl)pyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acidBinding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting in presence of NTSR2 ligand (S)-2-((2S,3S)-2-(2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)-N-(4-hydroxyphenethyl)pyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acid
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3786291 145978 0 None 4 2 Human 9.4 pKd = 9.4 Binding
Binding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting in presence of NTSR2 ligand (S)-2-((2S,3S)-2-(2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)-N-(4-hydroxyphenethyl)pyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acidBinding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting in presence of NTSR2 ligand (S)-2-((2S,3S)-2-(2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)-N-(4-hydroxyphenethyl)pyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acid
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3787706 145978 0 None 4 2 Human 9.4 pKd = 9.4 Binding
Binding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting in presence of NTSR2 ligand (S)-2-((2S,3S)-2-(2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)-N-(4-hydroxyphenethyl)pyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acidBinding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting in presence of NTSR2 ligand (S)-2-((2S,3S)-2-(2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)-N-(4-hydroxyphenethyl)pyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acid
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL4579623 145978 0 None 4 2 Human 9.4 pKd = 9.4 Binding
Binding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting in presence of NTSR2 ligand (S)-2-((2S,3S)-2-(2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)-N-(4-hydroxyphenethyl)pyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acidBinding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting in presence of NTSR2 ligand (S)-2-((2S,3S)-2-(2-((S)-1-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanoyl)-N-(4-hydroxyphenethyl)pyrrolidine-2-carboxamido)acetamido)-3-methylpentanamido)-4-methylpentanoic acid
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL342252 218452 0 None -4 4 Human 9.3 pKd = 9.3 Binding
Displacement of [3H]NT(8-13) from human NTR1 extracellular loop 1 F136A mutant expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from human NTR1 extracellular loop 1 F136A mutant expressed in HEK293 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2008.08.051
CHEMBL342252 218452 0 None -4 4 Human 9.3 pKd = 9.3 Binding
Displacement of [3H]NT(8-13) from human NTR1 extracellular loop 1 I329G mutant expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from human NTR1 extracellular loop 1 I329G mutant expressed in HEK293 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2008.08.051
127032412 145978 0 None 4 2 Human 9.3 pKd = 9.3 Binding
Binding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingBinding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3785364 145978 0 None 4 2 Human 9.3 pKd = 9.3 Binding
Binding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingBinding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3786291 145978 0 None 4 2 Human 9.3 pKd = 9.3 Binding
Binding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingBinding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3787706 145978 0 None 4 2 Human 9.3 pKd = 9.3 Binding
Binding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingBinding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL4579623 145978 0 None 4 2 Human 9.3 pKd = 9.3 Binding
Binding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingBinding affinity to NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
1574 9585 20 None -5 6 Human 9.3 pKd = 9.3 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm401491e
1579 9585 20 None -5 6 Human 9.3 pKd = 9.3 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm401491e
25077406 9585 20 None -5 6 Human 9.3 pKd = 9.3 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm401491e
3830 9585 20 None -5 6 Human 9.3 pKd = 9.3 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm401491e
CHEMBL407196 9585 20 None -5 6 Human 9.3 pKd = 9.3 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm401491e
127032412 145978 0 None 4 2 Human 9.2 pKd = 9.2 Binding
Binding affinity to human NTSR1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingBinding affinity to human NTSR1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3785364 145978 0 None 4 2 Human 9.2 pKd = 9.2 Binding
Binding affinity to human NTSR1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingBinding affinity to human NTSR1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3786291 145978 0 None 4 2 Human 9.2 pKd = 9.2 Binding
Binding affinity to human NTSR1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingBinding affinity to human NTSR1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3787706 145978 0 None 4 2 Human 9.2 pKd = 9.2 Binding
Binding affinity to human NTSR1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingBinding affinity to human NTSR1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL4579623 145978 0 None 4 2 Human 9.2 pKd = 9.2 Binding
Binding affinity to human NTSR1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingBinding affinity to human NTSR1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
1574 9585 20 None -5 6 Human 9.2 pKd = 9.2 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm200006c
1579 9585 20 None -5 6 Human 9.2 pKd = 9.2 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm200006c
25077406 9585 20 None -5 6 Human 9.2 pKd = 9.2 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm200006c
3830 9585 20 None -5 6 Human 9.2 pKd = 9.2 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm200006c
CHEMBL407196 9585 20 None -5 6 Human 9.2 pKd = 9.2 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm200006c
CHEMBL342252 218452 0 None -4 4 Human 9.2 pKd = 9.2 Binding
Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2008.08.051
CHEMBL342252 218452 0 None -4 4 Human 9.2 pKd = 9.2 Binding
Displacement of [3H]NT(8-13) from human NTR1 extracellular loop 1 H131A mutant expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from human NTR1 extracellular loop 1 H131A mutant expressed in HEK293 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2008.08.051
CHEMBL342252 218452 0 None -4 4 Human 9.2 pKd = 9.2 Binding
Displacement of [3H]NT(8-13) from human NTR1 extracellular loop 1 P133A mutant expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from human NTR1 extracellular loop 1 P133A mutant expressed in HEK293 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2008.08.051
CHEMBL342252 218452 0 None -4 4 Human 9.1 pKd = 9.1 Binding
Displacement of [3H]NT(8-13) from human NTR1 extracellular loop 1 F127A mutant expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from human NTR1 extracellular loop 1 F127A mutant expressed in HEK293 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2008.08.051
CHEMBL342252 218452 0 None -4 4 Human 9.1 pKd = 9.1 Binding
Displacement of [3H]NT(8-13) from human NTR1 extracellular loop 1 YIS328-330AAA mutant expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from human NTR1 extracellular loop 1 YIS328-330AAA mutant expressed in HEK293 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2008.08.051
CHEMBL405584 219346 0 None - 1 Human 8.9 pKd = 8.9 Binding
In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1
ChEMBL None None None None 10.1021/jm049644y
CHEMBL508567 221759 2 None - 1 Human 8.8 pKd = 8.8 Binding
Binding affinity to human recombinant NTS1 in HEK293T cells by competitive binding assayBinding affinity to human recombinant NTS1 in HEK293T cells by competitive binding assay
ChEMBL None None None CN[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cccc2cc[nH]c12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801481y
CHEMBL405584 219346 0 None - 1 Human 8.7 pKd = 8.7 Binding
In vitro inhibition of [3H]-NT binding to human striatal Neurotensin receptor 1In vitro inhibition of [3H]-NT binding to human striatal Neurotensin receptor 1
ChEMBL None None None None 10.1021/jm049644y
155547078 183315 0 None -3 2 Human 8.0 pKd = 8.0 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysis
ChEMBL 1456 42 15 15 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4534768 183315 0 None -3 2 Human 8.0 pKd = 8.0 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysis
ChEMBL 1456 42 15 15 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4597104 183315 0 None -3 2 Human 8.0 pKd = 8.0 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysis
ChEMBL 1456 42 15 15 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
127030965 145981 0 None -5 2 Human 7.8 pKd = 7.8 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
155559776 145981 0 None -5 2 Human 7.8 pKd = 7.8 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL3787709 145981 0 None -5 2 Human 7.8 pKd = 7.8 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4564746 145981 0 None -5 2 Human 7.8 pKd = 7.8 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL270332 217585 0 None - 1 Human 6.8 pKd = 6.8 Binding
Binding affinity to human recombinant NTS1 in HEK293T cells by competitive binding assayBinding affinity to human recombinant NTS1 in HEK293T cells by competitive binding assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC1=O 10.1021/jm801481y
119192 9259 54 None -3 9 Human 7.7 pKd = 7.7 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 F127A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 F127A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
1582 9259 54 None -3 9 Human 7.7 pKd = 7.7 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 F127A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 F127A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
CHEMBL506981 9259 54 None -3 9 Human 7.7 pKd = 7.7 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 F127A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 F127A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
DB06455 9259 54 None -3 9 Human 7.7 pKd = 7.7 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 F127A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 F127A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
155547078 183315 0 None -3 2 Human 8.6 pKd = 8.6 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysis
ChEMBL 1456 42 15 15 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4534768 183315 0 None -3 2 Human 8.6 pKd = 8.6 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysis
ChEMBL 1456 42 15 15 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4597104 183315 0 None -3 2 Human 8.6 pKd = 8.6 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysis
ChEMBL 1456 42 15 15 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
119192 9259 54 None -3 9 Human 7.6 pKd = 7.6 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 W134A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 W134A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
1582 9259 54 None -3 9 Human 7.6 pKd = 7.6 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 W134A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 W134A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
CHEMBL506981 9259 54 None -3 9 Human 7.6 pKd = 7.6 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 W134A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 W134A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
DB06455 9259 54 None -3 9 Human 7.6 pKd = 7.6 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 W134A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 W134A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
155569717 183018 0 None -1 2 Human 7.6 pKd = 7.6 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysis
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4537266 183018 0 None -1 2 Human 7.6 pKd = 7.6 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysis
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4594723 183018 0 None -1 2 Human 7.6 pKd = 7.6 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysis
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
119192 9259 54 None -3 9 Human 7.6 pKd = 7.6 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 W129A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 W129A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
1582 9259 54 None -3 9 Human 7.6 pKd = 7.6 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 W129A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 W129A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
CHEMBL506981 9259 54 None -3 9 Human 7.6 pKd = 7.6 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 W129A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 W129A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
DB06455 9259 54 None -3 9 Human 7.6 pKd = 7.6 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 W129A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 W129A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
127030965 145981 0 None -5 2 Human 8.4 pKd = 8.4 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells preincubated for 20 mins to 2 hrs followed by addition of NT (8 to 13) measured upto 180 mins by FACSCalibur flow cytometry analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells preincubated for 20 mins to 2 hrs followed by addition of NT (8 to 13) measured upto 180 mins by FACSCalibur flow cytometry analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
155559776 145981 0 None -5 2 Human 8.4 pKd = 8.4 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells preincubated for 20 mins to 2 hrs followed by addition of NT (8 to 13) measured upto 180 mins by FACSCalibur flow cytometry analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells preincubated for 20 mins to 2 hrs followed by addition of NT (8 to 13) measured upto 180 mins by FACSCalibur flow cytometry analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL3787709 145981 0 None -5 2 Human 8.4 pKd = 8.4 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells preincubated for 20 mins to 2 hrs followed by addition of NT (8 to 13) measured upto 180 mins by FACSCalibur flow cytometry analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells preincubated for 20 mins to 2 hrs followed by addition of NT (8 to 13) measured upto 180 mins by FACSCalibur flow cytometry analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4564746 145981 0 None -5 2 Human 8.4 pKd = 8.4 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells preincubated for 20 mins to 2 hrs followed by addition of NT (8 to 13) measured upto 180 mins by FACSCalibur flow cytometry analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells preincubated for 20 mins to 2 hrs followed by addition of NT (8 to 13) measured upto 180 mins by FACSCalibur flow cytometry analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
155569737 183414 0 None 1 2 Human 8.4 pKd = 8.4 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4457798 183414 0 None 1 2 Human 8.4 pKd = 8.4 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4597941 183414 0 None 1 2 Human 8.4 pKd = 8.4 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
155569737 183414 0 None 1 2 Human 8.4 pKd = 8.4 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells preincubated for 20 mins to 2 hrs followed by addition of NT (8 to 13) measured upto 180 mins by FACSCalibur flow cytometry analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells preincubated for 20 mins to 2 hrs followed by addition of NT (8 to 13) measured upto 180 mins by FACSCalibur flow cytometry analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4457798 183414 0 None 1 2 Human 8.4 pKd = 8.4 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells preincubated for 20 mins to 2 hrs followed by addition of NT (8 to 13) measured upto 180 mins by FACSCalibur flow cytometry analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells preincubated for 20 mins to 2 hrs followed by addition of NT (8 to 13) measured upto 180 mins by FACSCalibur flow cytometry analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4597941 183414 0 None 1 2 Human 8.4 pKd = 8.4 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells preincubated for 20 mins to 2 hrs followed by addition of NT (8 to 13) measured upto 180 mins by FACSCalibur flow cytometry analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells preincubated for 20 mins to 2 hrs followed by addition of NT (8 to 13) measured upto 180 mins by FACSCalibur flow cytometry analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
10010720 17915 0 None - 1 Rat 6.5 pKd = 6.5 Binding
Equilibrium dissociation constant at cloned rat Neurotensin receptor (NT) receptor expressed in CHO-K1 cells; 0.3-0.7 uMEquilibrium dissociation constant at cloned rat Neurotensin receptor (NT) receptor expressed in CHO-K1 cells; 0.3-0.7 uM
ChEMBL 835 27 10 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1[nH]c2c(OCCCCCN=C(N)N)cccc2c1CCCCCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)80338-3
CHEMBL1178333 17915 0 None - 1 Rat 6.5 pKd = 6.5 Binding
Equilibrium dissociation constant at cloned rat Neurotensin receptor (NT) receptor expressed in CHO-K1 cells; 0.3-0.7 uMEquilibrium dissociation constant at cloned rat Neurotensin receptor (NT) receptor expressed in CHO-K1 cells; 0.3-0.7 uM
ChEMBL 835 27 10 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1[nH]c2c(OCCCCCN=C(N)N)cccc2c1CCCCCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)80338-3
CHEMBL21448 17915 0 None - 1 Rat 6.5 pKd = 6.5 Binding
Equilibrium dissociation constant at cloned rat Neurotensin receptor (NT) receptor expressed in CHO-K1 cells; 0.3-0.7 uMEquilibrium dissociation constant at cloned rat Neurotensin receptor (NT) receptor expressed in CHO-K1 cells; 0.3-0.7 uM
ChEMBL 835 27 10 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1[nH]c2c(OCCCCCN=C(N)N)cccc2c1CCCCCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)80338-3
10033913 17916 0 None - 1 Rat 6.5 pKd = 6.5 Binding
Equilibrium dissociation constant at cloned rat Neurotensin receptor (NT) receptor expressed in CHO-K1 cells; 0.3-0.7 uMEquilibrium dissociation constant at cloned rat Neurotensin receptor (NT) receptor expressed in CHO-K1 cells; 0.3-0.7 uM
ChEMBL 750 25 8 8 4.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1[nH]c2c(OCCCCCN)cccc2c1CCCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)80338-3
CHEMBL1178334 17916 0 None - 1 Rat 6.5 pKd = 6.5 Binding
Equilibrium dissociation constant at cloned rat Neurotensin receptor (NT) receptor expressed in CHO-K1 cells; 0.3-0.7 uMEquilibrium dissociation constant at cloned rat Neurotensin receptor (NT) receptor expressed in CHO-K1 cells; 0.3-0.7 uM
ChEMBL 750 25 8 8 4.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1[nH]c2c(OCCCCCN)cccc2c1CCCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)80338-3
CHEMBL21521 17916 0 None - 1 Rat 6.5 pKd = 6.5 Binding
Equilibrium dissociation constant at cloned rat Neurotensin receptor (NT) receptor expressed in CHO-K1 cells; 0.3-0.7 uMEquilibrium dissociation constant at cloned rat Neurotensin receptor (NT) receptor expressed in CHO-K1 cells; 0.3-0.7 uM
ChEMBL 750 25 8 8 4.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1[nH]c2c(OCCCCCN)cccc2c1CCCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)80338-3
44274487 17920 0 None - 1 Rat 6.5 pKd = 6.5 Binding
Equilibrium dissociation constant at cloned rat Neurotensin receptor (NT) receptor expressed in CHO-K1 cells; 0.3-0.7 uMEquilibrium dissociation constant at cloned rat Neurotensin receptor (NT) receptor expressed in CHO-K1 cells; 0.3-0.7 uM
ChEMBL 858 27 10 7 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1[nH]c2c(OCCCCCN=C(N)N)cccc2c1CCCCCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)80338-3
CHEMBL1178343 17920 0 None - 1 Rat 6.5 pKd = 6.5 Binding
Equilibrium dissociation constant at cloned rat Neurotensin receptor (NT) receptor expressed in CHO-K1 cells; 0.3-0.7 uMEquilibrium dissociation constant at cloned rat Neurotensin receptor (NT) receptor expressed in CHO-K1 cells; 0.3-0.7 uM
ChEMBL 858 27 10 7 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1[nH]c2c(OCCCCCN=C(N)N)cccc2c1CCCCCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)80338-3
CHEMBL21892 17920 0 None - 1 Rat 6.5 pKd = 6.5 Binding
Equilibrium dissociation constant at cloned rat Neurotensin receptor (NT) receptor expressed in CHO-K1 cells; 0.3-0.7 uMEquilibrium dissociation constant at cloned rat Neurotensin receptor (NT) receptor expressed in CHO-K1 cells; 0.3-0.7 uM
ChEMBL 858 27 10 7 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1[nH]c2c(OCCCCCN=C(N)N)cccc2c1CCCCCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)80338-3
119192 9259 54 None -3 9 Human 7.5 pKd = 7.5 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 F136A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 F136A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
1582 9259 54 None -3 9 Human 7.5 pKd = 7.5 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 F136A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 F136A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
CHEMBL506981 9259 54 None -3 9 Human 7.5 pKd = 7.5 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 F136A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 F136A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
DB06455 9259 54 None -3 9 Human 7.5 pKd = 7.5 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 F136A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 F136A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
155569737 183414 0 None 1 2 Human 8.2 pKd = 8.2 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4457798 183414 0 None 1 2 Human 8.2 pKd = 8.2 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4597941 183414 0 None 1 2 Human 8.2 pKd = 8.2 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 60 mins in presence of NT (8 to 13) without compound washout by Hoechst H33342 staining confocal microscopy analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
155569717 183018 0 None -1 2 Human 8.2 pKd = 8.2 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysis
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4537266 183018 0 None -1 2 Human 8.2 pKd = 8.2 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysis
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4594723 183018 0 None -1 2 Human 8.2 pKd = 8.2 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysis
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
127030965 145981 0 None -5 2 Human 8.1 pKd = 8.1 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
155559776 145981 0 None -5 2 Human 8.1 pKd = 8.1 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL3787709 145981 0 None -5 2 Human 8.1 pKd = 8.1 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4564746 145981 0 None -5 2 Human 8.1 pKd = 8.1 Binding
Binding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysisBinding affinity to human neurotensin receptor 1 stably expressed in CHO cells incubated for 75 mins in presence of NT (8 to 13) followed by compound washout with HBSS-BSA by Hoechst H33342 staining based confocal microscopy analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
119192 9259 54 None -3 9 Human 8.1 pKd = 8.1 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 H131A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 H131A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
1582 9259 54 None -3 9 Human 8.1 pKd = 8.1 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 H131A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 H131A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
CHEMBL506981 9259 54 None -3 9 Human 8.1 pKd = 8.1 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 H131A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 H131A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
DB06455 9259 54 None -3 9 Human 8.1 pKd = 8.1 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 H131A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 H131A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
119192 9259 54 None -3 9 Human 8.1 pKd = 8.1 Binding
Displacement of [3H]SR48692 from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]SR48692 from wild type human NTR1 expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
1582 9259 54 None -3 9 Human 8.1 pKd = 8.1 Binding
Displacement of [3H]SR48692 from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]SR48692 from wild type human NTR1 expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
CHEMBL506981 9259 54 None -3 9 Human 8.1 pKd = 8.1 Binding
Displacement of [3H]SR48692 from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]SR48692 from wild type human NTR1 expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
DB06455 9259 54 None -3 9 Human 8.1 pKd = 8.1 Binding
Displacement of [3H]SR48692 from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]SR48692 from wild type human NTR1 expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
119192 9259 54 None -3 9 Human 8.0 pKd = 8.0 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 P133A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 P133A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
1582 9259 54 None -3 9 Human 8.0 pKd = 8.0 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 P133A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 P133A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
CHEMBL506981 9259 54 None -3 9 Human 8.0 pKd = 8.0 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 P133A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 P133A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
DB06455 9259 54 None -3 9 Human 8.0 pKd = 8.0 Binding
Displacement of [3H]SR48692 from human NTR1 extracellular loop 1 P133A mutant expressed in HEK293 cellsDisplacement of [3H]SR48692 from human NTR1 extracellular loop 1 P133A mutant expressed in HEK293 cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2008.08.051
CHEMBL405151 219324 0 None - 1 Mouse 10.9 pKi = 10.9 Binding
Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80698-8
CHEMBL342252 218452 0 None 4 4 Mouse 10.7 pKi = 10.7 Binding
Binding affinity to NTR1 in mouse brain membraneBinding affinity to NTR1 in mouse brain membrane
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmcl.2008.01.110
CHEMBL342252 218452 0 None 4 4 Mouse 10.7 pKi = 10.7 Binding
Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80698-8
CHEMBL264534 217405 0 None - 1 Mouse 10.6 pKi = 10.6 Binding
Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80698-8
CHEMBL427604 220133 0 None - 1 Mouse 10.2 pKi = 10.2 Binding
Binding affinity for Neurotensin ReceptorBinding affinity for Neurotensin Receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/0960-894X(95)00155-M
CHEMBL266571 217468 2 None 2041 2 Mouse 10.2 pKi = 10.2 Binding
Compound was tested in vitro for its binding affinity against Neurotensin Receptor after peripheral administrationCompound was tested in vitro for its binding affinity against Neurotensin Receptor after peripheral administration
ChEMBL None None None CN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1016/0960-894X(95)00155-M
44264095 210411 0 None - 1 Mouse 10.0 pKi = 10 Binding
Binding affinity for Neurotensin ReceptorBinding affinity for Neurotensin Receptor
ChEMBL 767 20 9 7 1.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)C(CCCN=C(N)N)CCCN=C(N)N)C(C)(C)C)C(=O)O 10.1016/0960-894X(95)00155-M
CHEMBL6716 210411 0 None - 1 Mouse 10.0 pKi = 10 Binding
Binding affinity for Neurotensin ReceptorBinding affinity for Neurotensin Receptor
ChEMBL 767 20 9 7 1.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)C(CCCN=C(N)N)CCCN=C(N)N)C(C)(C)C)C(=O)O 10.1016/0960-894X(95)00155-M
CHEMBL174771 215636 0 None - 1 Mouse 10.0 pKi = 10 Binding
Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80698-8
CHEMBL412980 219816 0 None - 1 Mouse 10.0 pKi = 10.0 Binding
Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80698-8
CHEMBL441754 220674 0 None - 1 Mouse 9.9 pKi = 9.9 Binding
Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80698-8
1569 8907 32 None 2 2 Human 9.9 pKi = 9.9 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
5311318 8907 32 None 2 2 Human 9.9 pKi = 9.9 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
CHEMBL415788 8907 32 None 2 2 Human 9.9 pKi = 9.9 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
CHEMBL344337 218484 0 None 14 2 Mouse 9.9 pKi = 9.9 Binding
Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80698-8
CHEMBL342252 218452 0 None -4 4 Human 9.9 pKi = 9.9 Binding
Binding affinity to human NTR1Binding affinity to human NTR1
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
1569 8907 32 None 2 2 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
5311318 8907 32 None 2 2 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
CHEMBL415788 8907 32 None 2 2 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
CHEMBL1793865 215708 0 None - 1 Mouse 9.8 pKi = 9.8 Binding
Binding affinity for Neurotensin ReceptorBinding affinity for Neurotensin Receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/0960-894X(95)00155-M
1574 9585 20 None 3 6 Mouse 9.8 pKi = 9.8 Binding
Concentration producing half maximal inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptor in neonatal mouse whole brain (minus cerebellum)Concentration producing half maximal inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptor in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None None 10.1016/S0960-894X(00)80698-8
1579 9585 20 None 3 6 Mouse 9.8 pKi = 9.8 Binding
Concentration producing half maximal inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptor in neonatal mouse whole brain (minus cerebellum)Concentration producing half maximal inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptor in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None None 10.1016/S0960-894X(00)80698-8
25077406 9585 20 None 3 6 Mouse 9.8 pKi = 9.8 Binding
Concentration producing half maximal inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptor in neonatal mouse whole brain (minus cerebellum)Concentration producing half maximal inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptor in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None None 10.1016/S0960-894X(00)80698-8
3830 9585 20 None 3 6 Mouse 9.8 pKi = 9.8 Binding
Concentration producing half maximal inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptor in neonatal mouse whole brain (minus cerebellum)Concentration producing half maximal inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptor in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None None 10.1016/S0960-894X(00)80698-8
CHEMBL407196 9585 20 None 3 6 Mouse 9.8 pKi = 9.8 Binding
Concentration producing half maximal inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptor in neonatal mouse whole brain (minus cerebellum)Concentration producing half maximal inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptor in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None None 10.1016/S0960-894X(00)80698-8
1569 8907 32 None 2 2 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assayDisplacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assay
ChEMBL None None None None 10.1016/j.bmc.2022.116720
5311318 8907 32 None 2 2 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assayDisplacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assay
ChEMBL None None None None 10.1016/j.bmc.2022.116720
CHEMBL415788 8907 32 None 2 2 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assayDisplacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assay
ChEMBL None None None None 10.1016/j.bmc.2022.116720
CHEMBL413433 219847 0 None - 1 Mouse 9.7 pKi = 9.7 Binding
Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80698-8
155569028 183354 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL 831 25 13 10 -0.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00122
CHEMBL4593174 183354 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL 831 25 13 10 -0.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00122
CHEMBL4597456 183354 0 None - 1 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL 831 25 13 10 -0.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00122
54582126 68063 0 None 2 2 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL1766935 68063 0 None 2 2 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
1569 8907 32 None 2 2 Human 9.6 pKi = 9.6 Binding
Binding affinity to human NTS1RBinding affinity to human NTS1R
ChEMBL None None None None 10.1021/acsmedchemlett.9b00388
5311318 8907 32 None 2 2 Human 9.6 pKi = 9.6 Binding
Binding affinity to human NTS1RBinding affinity to human NTS1R
ChEMBL None None None None 10.1021/acsmedchemlett.9b00388
CHEMBL415788 8907 32 None 2 2 Human 9.6 pKi = 9.6 Binding
Binding affinity to human NTS1RBinding affinity to human NTS1R
ChEMBL None None None None 10.1021/acsmedchemlett.9b00388
1569 8907 32 None 2 2 Human 9.6 pKi = 9.6 Binding
Binding affinity to human neurotensin receptor 1Binding affinity to human neurotensin receptor 1
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
5311318 8907 32 None 2 2 Human 9.6 pKi = 9.6 Binding
Binding affinity to human neurotensin receptor 1Binding affinity to human neurotensin receptor 1
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
CHEMBL415788 8907 32 None 2 2 Human 9.6 pKi = 9.6 Binding
Binding affinity to human neurotensin receptor 1Binding affinity to human neurotensin receptor 1
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
CHEMBL1766928 215644 0 None 5 2 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)CC1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL366912 218936 0 None - 1 Mouse 9.6 pKi = 9.6 Binding
Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80698-8
127033024 145977 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 991 32 14 13 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCOCCOCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786779 145977 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 991 32 14 13 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCOCCOCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787705 145977 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 991 32 14 13 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCOCCOCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
1574 9585 20 None -5 6 Human 9.6 pKi = 9.6 Binding
Binding affinity to human NTS1 receptor by radioligand displacement assayBinding affinity to human NTS1 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
1579 9585 20 None -5 6 Human 9.6 pKi = 9.6 Binding
Binding affinity to human NTS1 receptor by radioligand displacement assayBinding affinity to human NTS1 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
25077406 9585 20 None -5 6 Human 9.6 pKi = 9.6 Binding
Binding affinity to human NTS1 receptor by radioligand displacement assayBinding affinity to human NTS1 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
3830 9585 20 None -5 6 Human 9.6 pKi = 9.6 Binding
Binding affinity to human NTS1 receptor by radioligand displacement assayBinding affinity to human NTS1 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
CHEMBL407196 9585 20 None -5 6 Human 9.6 pKi = 9.6 Binding
Binding affinity to human NTS1 receptor by radioligand displacement assayBinding affinity to human NTS1 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
CHEMBL342252 218452 0 None -4 4 Human 9.6 pKi = 9.6 Binding
In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm049644y
155544004 180091 0 None - 1 Human 9.6 pKi = 9.6 Binding
Antagonist activity at NSTR1 (unknown origin) assessed as inhibitory constantAntagonist activity at NSTR1 (unknown origin) assessed as inhibitory constant
ChEMBL 1672 50 23 21 -3.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)C1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00122
CHEMBL4526200 180091 0 None - 1 Human 9.6 pKi = 9.6 Binding
Antagonist activity at NSTR1 (unknown origin) assessed as inhibitory constantAntagonist activity at NSTR1 (unknown origin) assessed as inhibitory constant
ChEMBL 1672 50 23 21 -3.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)C1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00122
CHEMBL468951 220805 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
CHEMBL443967 220706 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00122
CHEMBL4528687 220706 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00122
CHEMBL342252 218452 0 None -4 4 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm401491e
1569 8907 32 None 2 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL None None None None 10.1021/acsmedchemlett.9b00122
5311318 8907 32 None 2 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL None None None None 10.1021/acsmedchemlett.9b00122
CHEMBL415788 8907 32 None 2 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL None None None None 10.1021/acsmedchemlett.9b00122
127031851 145982 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 991 32 14 13 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN/C(N)=N\C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3785233 145982 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 991 32 14 13 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN/C(N)=N\C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787710 145982 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 991 32 14 13 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN/C(N)=N\C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL6508 222638 0 None - 1 Mouse 9.4 pKi = 9.4 Binding
Binding affinity for Neurotensin ReceptorBinding affinity for Neurotensin Receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC[C@@H](N)CCCCN)C(C)(C)C)C(=O)O 10.1016/0960-894X(95)00155-M
127031284 145979 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 1047 34 14 13 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3787200 145979 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 1047 34 14 13 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3787707 145979 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 1047 34 14 13 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
127032102 145976 0 None 1 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 931 28 14 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786852 145976 0 None 1 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 931 28 14 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787704 145976 0 None 1 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 931 28 14 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
127032412 145978 0 None 4 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3785364 145978 0 None 4 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3786291 145978 0 None 4 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3787706 145978 0 None 4 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL4579623 145978 0 None 4 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
127032412 145978 0 None 4 2 Human 9.3 pKi = 9.3 Binding
Binding affinity to human neurotensin receptor 1Binding affinity to human neurotensin receptor 1
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acsmedchemlett.9b00462
CHEMBL3785364 145978 0 None 4 2 Human 9.3 pKi = 9.3 Binding
Binding affinity to human neurotensin receptor 1Binding affinity to human neurotensin receptor 1
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acsmedchemlett.9b00462
CHEMBL3786291 145978 0 None 4 2 Human 9.3 pKi = 9.3 Binding
Binding affinity to human neurotensin receptor 1Binding affinity to human neurotensin receptor 1
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acsmedchemlett.9b00462
CHEMBL3787706 145978 0 None 4 2 Human 9.3 pKi = 9.3 Binding
Binding affinity to human neurotensin receptor 1Binding affinity to human neurotensin receptor 1
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acsmedchemlett.9b00462
CHEMBL4579623 145978 0 None 4 2 Human 9.3 pKi = 9.3 Binding
Binding affinity to human neurotensin receptor 1Binding affinity to human neurotensin receptor 1
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acsmedchemlett.9b00462
CHEMBL443967 220706 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2008.08.051
CHEMBL4528687 220706 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2008.08.051
CHEMBL342252 218452 0 None 4 4 Mouse 9.3 pKi = 9.3 Binding
Binding affinity for Neurotensin ReceptorBinding affinity for Neurotensin Receptor
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/0960-894X(95)00155-M
127033029 145983 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 1047 34 14 13 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3786771 145983 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 1047 34 14 13 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3787711 145983 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 1047 34 14 13 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL1766929 215645 1 None 8 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
127032412 145978 0 None 4 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3785364 145978 0 None 4 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3786291 145978 0 None 4 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3787706 145978 0 None 4 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL4579623 145978 0 None 4 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 987 30 14 11 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL342252 218452 0 None -4 4 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2008.08.051
127032102 145976 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 931 28 14 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786852 145976 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 931 28 14 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787704 145976 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 931 28 14 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL504768 220963 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)N=[N+]=[N-])C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
155529795 183121 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1253 37 14 14 2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4463399 183121 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1253 37 14 14 2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4595550 183121 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1253 37 14 14 2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
142489081 183430 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL 831 23 13 10 -0.8 CN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00122
CHEMBL4567709 183430 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL 831 23 13 10 -0.8 CN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00122
CHEMBL4598051 183430 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL 831 23 13 10 -0.8 CN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00122
CHEMBL425847 220120 0 None - 1 Mouse 9.0 pKi = 9.0 Binding
Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80698-8
72737612 110367 0 None 70 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 958 20 5 15 4.6 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(C(=O)N(C)CCCN(C)CCCCc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3F)nn2)cc1C(C)C 10.1021/jm401491e
CHEMBL3086356 110367 0 None 70 2 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 958 20 5 15 4.6 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccc(C(=O)N(C)CCCN(C)CCCCc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3F)nn2)cc1C(C)C 10.1021/jm401491e
155552815 183198 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL 873 26 13 10 -0.5 CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acsmedchemlett.9b00122
CHEMBL4544373 183198 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL 873 26 13 10 -0.5 CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acsmedchemlett.9b00122
CHEMBL4596137 183198 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL 873 26 13 10 -0.5 CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acsmedchemlett.9b00122
1580 10437 46 None 1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm401491e
5311451 10437 46 None 1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm401491e
CHEMBL3040381 10437 46 None 1 4 Human 9.0 pKi = 9 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm401491e
CHEMBL342252 218452 0 None -4 4 Human 9.0 pKi = 9.0 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
1569 8907 32 None 2 2 Human 9.0 pKi = 9.0 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysis
ChEMBL None None None None 10.1021/acs.jmedchem.6b01848
5311318 8907 32 None 2 2 Human 9.0 pKi = 9.0 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysis
ChEMBL None None None None 10.1021/acs.jmedchem.6b01848
CHEMBL415788 8907 32 None 2 2 Human 9.0 pKi = 9.0 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysis
ChEMBL None None None None 10.1021/acs.jmedchem.6b01848
1574 9585 20 None -3 6 Rat 9.0 pKi = 9.0 Binding
Displacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL None None None None 10.1021/jm500857r
1579 9585 20 None -3 6 Rat 9.0 pKi = 9.0 Binding
Displacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL None None None None 10.1021/jm500857r
25077406 9585 20 None -3 6 Rat 9.0 pKi = 9.0 Binding
Displacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL None None None None 10.1021/jm500857r
3830 9585 20 None -3 6 Rat 9.0 pKi = 9.0 Binding
Displacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL None None None None 10.1021/jm500857r
CHEMBL407196 9585 20 None -3 6 Rat 9.0 pKi = 9.0 Binding
Displacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL None None None None 10.1021/jm500857r
1580 10437 46 None 1 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/acs.jmedchem.5b01495
5311451 10437 46 None 1 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/acs.jmedchem.5b01495
CHEMBL3040381 10437 46 None 1 4 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/acs.jmedchem.5b01495
CHEMBL269601 217579 0 None - 1 Mouse 9.0 pKi = 9.0 Binding
Binding affinity for Neurotensin ReceptorBinding affinity for Neurotensin Receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC[C@@H](N)CCCCN)C(C)(C)C)C(=O)O 10.1016/0960-894X(95)00155-M
155522777 183312 0 None -4 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL 816 22 13 10 -1.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/acsmedchemlett.9b00122
CHEMBL4452276 183312 0 None -4 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL 816 22 13 10 -1.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/acsmedchemlett.9b00122
CHEMBL4597094 183312 0 None -4 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL 816 22 13 10 -1.1 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/acsmedchemlett.9b00122
1574 9585 20 None -5 6 Human 8.9 pKi = 8.9 Binding
Binding affinity to human neurotensin receptor 1Binding affinity to human neurotensin receptor 1
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
1579 9585 20 None -5 6 Human 8.9 pKi = 8.9 Binding
Binding affinity to human neurotensin receptor 1Binding affinity to human neurotensin receptor 1
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
25077406 9585 20 None -5 6 Human 8.9 pKi = 8.9 Binding
Binding affinity to human neurotensin receptor 1Binding affinity to human neurotensin receptor 1
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
3830 9585 20 None -5 6 Human 8.9 pKi = 8.9 Binding
Binding affinity to human neurotensin receptor 1Binding affinity to human neurotensin receptor 1
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
CHEMBL407196 9585 20 None -5 6 Human 8.9 pKi = 8.9 Binding
Binding affinity to human neurotensin receptor 1Binding affinity to human neurotensin receptor 1
ChEMBL None None None None 10.1021/acsmedchemlett.9b00462
1569 8907 32 None 2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2022.116720
5311318 8907 32 None 2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2022.116720
CHEMBL415788 8907 32 None 2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2022.116720
155529795 183121 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1253 37 14 14 2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4463399 183121 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1253 37 14 14 2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4595550 183121 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1253 37 14 14 2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
1569 8907 32 None 2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL None None None None 10.1021/acs.jmedchem.8b00175
5311318 8907 32 None 2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL None None None None 10.1021/acs.jmedchem.8b00175
CHEMBL415788 8907 32 None 2 2 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL None None None None 10.1021/acs.jmedchem.8b00175
155569737 183414 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4457798 183414 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4597941 183414 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
155569737 183414 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4457798 183414 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4597941 183414 0 None 1 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1597 44 16 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
1580 10437 46 None -1 4 Rat 8.9 pKi = 8.9 Binding
Displacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm500857r
5311451 10437 46 None -1 4 Rat 8.9 pKi = 8.9 Binding
Displacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm500857r
CHEMBL3040381 10437 46 None -1 4 Rat 8.9 pKi = 8.9 Binding
Displacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assayDisplacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1021/jm500857r
1574 9585 20 None -5 6 Human 8.8 pKi = 8.8 Binding
Displacement of radiolabeled neurotensin from human neurotensin receptor 1Displacement of radiolabeled neurotensin from human neurotensin receptor 1
ChEMBL None None None None 10.1021/jm8007618
1579 9585 20 None -5 6 Human 8.8 pKi = 8.8 Binding
Displacement of radiolabeled neurotensin from human neurotensin receptor 1Displacement of radiolabeled neurotensin from human neurotensin receptor 1
ChEMBL None None None None 10.1021/jm8007618
25077406 9585 20 None -5 6 Human 8.8 pKi = 8.8 Binding
Displacement of radiolabeled neurotensin from human neurotensin receptor 1Displacement of radiolabeled neurotensin from human neurotensin receptor 1
ChEMBL None None None None 10.1021/jm8007618
3830 9585 20 None -5 6 Human 8.8 pKi = 8.8 Binding
Displacement of radiolabeled neurotensin from human neurotensin receptor 1Displacement of radiolabeled neurotensin from human neurotensin receptor 1
ChEMBL None None None None 10.1021/jm8007618
CHEMBL407196 9585 20 None -5 6 Human 8.8 pKi = 8.8 Binding
Displacement of radiolabeled neurotensin from human neurotensin receptor 1Displacement of radiolabeled neurotensin from human neurotensin receptor 1
ChEMBL None None None None 10.1021/jm8007618
155569717 183018 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4537266 183018 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4594723 183018 0 None -1 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
155551504 183309 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL 831 22 12 10 -0.8 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/acsmedchemlett.9b00122
CHEMBL4541665 183309 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL 831 22 12 10 -0.8 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/acsmedchemlett.9b00122
CHEMBL4597084 183309 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL 831 22 12 10 -0.8 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/acsmedchemlett.9b00122
CHEMBL254769 217290 0 None -2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CNCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
1574 9585 20 None -5 6 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None None 10.1021/jm801072v
1579 9585 20 None -5 6 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None None 10.1021/jm801072v
25077406 9585 20 None -5 6 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None None 10.1021/jm801072v
3830 9585 20 None -5 6 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None None 10.1021/jm801072v
CHEMBL407196 9585 20 None -5 6 Human 8.8 pKi = 8.8 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None None 10.1021/jm801072v
1574 9585 20 None -3 6 Rat 8.8 pKi = 8.8 Binding
Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assay
ChEMBL None None None None 10.1016/j.bmcl.2014.11.047
1579 9585 20 None -3 6 Rat 8.8 pKi = 8.8 Binding
Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assay
ChEMBL None None None None 10.1016/j.bmcl.2014.11.047
25077406 9585 20 None -3 6 Rat 8.8 pKi = 8.8 Binding
Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assay
ChEMBL None None None None 10.1016/j.bmcl.2014.11.047
3830 9585 20 None -3 6 Rat 8.8 pKi = 8.8 Binding
Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assay
ChEMBL None None None None 10.1016/j.bmcl.2014.11.047
CHEMBL407196 9585 20 None -3 6 Rat 8.8 pKi = 8.8 Binding
Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assay
ChEMBL None None None None 10.1016/j.bmcl.2014.11.047
127034293 145980 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 1427 41 14 17 2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787095 145980 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 1427 41 14 17 2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787708 145980 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 1427 41 14 17 2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
127033029 145983 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1047 34 14 13 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3786771 145983 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1047 34 14 13 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
CHEMBL3787711 145983 0 None - 1 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1047 34 14 13 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.5b01495
162668357 189252 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1614 47 22 20 -3.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4786574 189252 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1614 47 22 20 -3.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL344337 218484 0 None -14 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
155569717 183018 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4537266 183018 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4594723 183018 0 None -1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL367552 218938 0 None - 1 Mouse 8.0 pKi = 8 Binding
Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(N)=O 10.1016/S0960-894X(00)80698-8
44572621 195032 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 817 23 11 10 0.5 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@](C)(N)CCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL499673 195032 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 817 23 11 10 0.5 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@](C)(N)CCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
56672657 69970 0 None - 1 Rat 7.0 pKi = 7 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 736 20 7 8 2.5 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)c1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL1790460 69970 0 None - 1 Rat 7.0 pKi = 7 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 736 20 7 8 2.5 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)c1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL172313 215631 0 None -22 3 Human 7.0 pKi = 7 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm200006c
73354481 96132 0 None - 1 Rat 6.0 pKi = 6 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 768 21 7 8 3.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CC1CC2CCC1C2)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL2369588 96132 0 None - 1 Rat 6.0 pKi = 6 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 768 21 7 8 3.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CC1CC2CCC1C2)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL1766943 215654 0 None -100 2 Human 5.0 pKi = 5 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(CCc1ccccn1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
49837912 111069 3 None - 1 Human 5.0 pKi = 5 Binding
Inhibition of NTS1 receptor (unknown origin)Inhibition of NTS1 receptor (unknown origin)
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
CHEMBL3099773 111069 3 None - 1 Human 5.0 pKi = 5 Binding
Inhibition of NTS1 receptor (unknown origin)Inhibition of NTS1 receptor (unknown origin)
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1nc(C(=O)N[C@@H](CC(C)C)C(=O)O)cn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
118729839 124722 0 None -79 2 Rat 5.0 pKi = 5.0 Binding
Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding AssayDisplacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay
ChEMBL 499 7 2 6 5.7 COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 10.1016/j.bmcl.2015.03.083
CHEMBL3403506 124722 0 None -79 2 Rat 5.0 pKi = 5.0 Binding
Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding AssayDisplacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay
ChEMBL 499 7 2 6 5.7 COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 10.1016/j.bmcl.2015.03.083
CHEMBL508380 221662 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)N=[N+]=[N-])C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL1766924 215640 0 None 2 2 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm200006c
CHEMBL171907 215628 0 None - 1 Mouse 7.0 pKi = 7.0 Binding
Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80698-8
CHEMBL1766927 215643 0 None 1 2 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm200006c
10463024 96253 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Neurotensin receptor binding affinity by displacement of [3H]- neurotensinNeurotensin receptor binding affinity by displacement of [3H]- neurotensin
ChEMBL 794 20 7 8 3.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80282-6
CHEMBL2372106 96253 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Neurotensin receptor binding affinity by displacement of [3H]- neurotensinNeurotensin receptor binding affinity by displacement of [3H]- neurotensin
ChEMBL 794 20 7 8 3.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80282-6
11285912 130454 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1
ChEMBL 843 23 10 10 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)N1CC[C@]2(CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C1=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm049644y
CHEMBL362127 130454 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1
ChEMBL 843 23 10 10 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)N1CC[C@]2(CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C1=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm049644y
10463024 96253 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 794 20 7 8 3.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL2372106 96253 0 None - 1 Rat 6.9 pKi = 6.9 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 794 20 7 8 3.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL367873 218939 0 None - 1 Mouse 4.9 pKi = 4.9 Binding
Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1016/S0960-894X(00)80698-8
90644394 118924 0 None -10 2 Rat 5.9 pKi = 5.9 Binding
Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding AssayDisplacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay
ChEMBL 499 7 2 6 5.2 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 10.1016/j.bmcl.2015.03.083
CHEMBL3290101 118924 0 None -10 2 Rat 5.9 pKi = 5.9 Binding
Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding AssayDisplacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay
ChEMBL 499 7 2 6 5.2 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1cccc2ccccc12 10.1016/j.bmcl.2015.03.083
56664793 70109 0 None - 1 Rat 5.9 pKi = 5.9 Binding
Tested for binding affinity against Neurotensin receptorTested for binding affinity against Neurotensin receptor
ChEMBL 712 18 7 8 5.1 CC[C@H](C)[C@H](NC(=O)N(Cc1ccc(O)cc1)c1cccc(NC(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)c1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/0960-894X(95)00195-Y
CHEMBL1794003 70109 0 None - 1 Rat 5.9 pKi = 5.9 Binding
Tested for binding affinity against Neurotensin receptorTested for binding affinity against Neurotensin receptor
ChEMBL 712 18 7 8 5.1 CC[C@H](C)[C@H](NC(=O)N(Cc1ccc(O)cc1)c1cccc(NC(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)c1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/0960-894X(95)00195-Y
CHEMBL1766926 215642 0 None -15 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm200006c
CHEMBL1766934 215650 1 None 2 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL1766933 215649 0 None -18 2 Human 4.9 pKi = 4.9 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
44572618 195760 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 845 24 11 10 0.3 CC(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
CHEMBL508507 195760 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 845 24 11 10 0.3 CC(=O)N[C@@H](CCCCN)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
CHEMBL2310906 216278 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm049644y
44396911 73712 0 None - 1 Human 4.9 pKi = 4.9 Binding
In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1
ChEMBL 843 23 10 10 -1.0 CC[C@H](C)[C@H](NC(=O)C(Cc1ccc(O)cc1)N1CC[C@@]2(CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C1=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm049644y
CHEMBL186638 73712 0 None - 1 Human 4.9 pKi = 4.9 Binding
In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1
ChEMBL 843 23 10 10 -1.0 CC[C@H](C)[C@H](NC(=O)C(Cc1ccc(O)cc1)N1CC[C@@]2(CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C1=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm049644y
145974670 171417 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 799 13 9 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4216311 171417 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 799 13 9 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
168269036 196793 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL 895 28 14 13 -1.4 CC(C)C[C@H](NC(=O)[C@@H](CCSSCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O 10.1016/j.bmc.2022.116720
CHEMBL5171551 196793 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL 895 28 14 13 -1.4 CC(C)C[C@H](NC(=O)[C@@H](CCSSCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O 10.1016/j.bmc.2022.116720
145966676 171027 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 784 13 9 10 0.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4211344 171027 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 784 13 9 10 0.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
145975635 170565 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 826 13 8 9 3.3 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCC[C@](C)(N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4205887 170565 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 826 13 8 9 3.3 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCC[C@](C)(N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
145978385 170711 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 812 23 8 10 1.9 CCOC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(C)(C)C 10.1021/acs.jmedchem.8b00175
CHEMBL4207506 170711 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 812 23 8 10 1.9 CCOC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(C)(C)C 10.1021/acs.jmedchem.8b00175
10440472 186895 0 None - 1 Mouse 7.8 pKi = 7.8 Binding
Displacement of [3H]-neurotensin from NTS1 in mouse brain membrane incubated for 30 mins by liquid scintillation counter analysisDisplacement of [3H]-neurotensin from NTS1 in mouse brain membrane incubated for 30 mins by liquid scintillation counter analysis
ChEMBL 823 15 11 9 -0.2 CC(C)C[C@H](NC(=O)[C@@H]1CCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4748559 186895 0 None - 1 Mouse 7.8 pKi = 7.8 Binding
Displacement of [3H]-neurotensin from NTS1 in mouse brain membrane incubated for 30 mins by liquid scintillation counter analysisDisplacement of [3H]-neurotensin from NTS1 in mouse brain membrane incubated for 30 mins by liquid scintillation counter analysis
ChEMBL 823 15 11 9 -0.2 CC(C)C[C@H](NC(=O)[C@@H]1CCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4436458 220940 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)N(C)C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N 10.1016/j.bmc.2008.08.051
CHEMBL503059 220940 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)N(C)C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N 10.1016/j.bmc.2008.08.051
44265474 105228 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Neurotensin receptor binding affinity by displacement of [3H]- neurotensinNeurotensin receptor binding affinity by displacement of [3H]- neurotensin
ChEMBL 824 23 8 10 2.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NNCC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80282-6
CHEMBL275752 105228 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Neurotensin receptor binding affinity by displacement of [3H]- neurotensinNeurotensin receptor binding affinity by displacement of [3H]- neurotensin
ChEMBL 824 23 8 10 2.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NNCC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80282-6
162660488 188144 0 None -10 2 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1646 51 24 21 -3.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4763222 188144 0 None -10 2 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1646 51 24 21 -3.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL267748 217508 0 None - 1 Rat 5.8 pKi = 5.8 Binding
Neurotensin receptor binding affinity by displacement of [3H]- neurotensinNeurotensin receptor binding affinity by displacement of [3H]- neurotensin
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)N/C=C/C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80282-6
44264255 173332 0 None - 1 Mouse 7.8 pKi = 7.8 Binding
Binding affinity for Neurotensin ReceptorBinding affinity for Neurotensin Receptor
ChEMBL 683 18 7 7 2.4 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)C(CCCN)CCCN)C(C)(C)C)C(=O)O 10.1016/0960-894X(95)00155-M
CHEMBL427956 173332 0 None - 1 Mouse 7.8 pKi = 7.8 Binding
Binding affinity for Neurotensin ReceptorBinding affinity for Neurotensin Receptor
ChEMBL 683 18 7 7 2.4 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)C(CCCN)CCCN)C(C)(C)C)C(=O)O 10.1016/0960-894X(95)00155-M
CHEMBL411195 219648 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)CN(CCCCN)C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL267459 217500 0 None - 1 Mouse 7.8 pKi = 7.8 Binding
Binding affinity for Neurotensin ReceptorBinding affinity for Neurotensin Receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC[C@@H](N)CCCN=C(N)N)C(C)(C)C)C(=O)O 10.1016/0960-894X(95)00155-M
11228237 175088 0 None - 1 Human 4.8 pKi = 4.8 Binding
In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1
ChEMBL 843 23 10 10 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)N1CC[C@@]2(CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C1=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm049644y
CHEMBL434134 175088 0 None - 1 Human 4.8 pKi = 4.8 Binding
In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1
ChEMBL 843 23 10 10 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)N1CC[C@@]2(CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C1=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm049644y
CHEMBL267714 217507 0 None -17 2 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
90644389 118919 0 None -1 2 Rat 6.8 pKi = 6.8 Binding
Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding AssayDisplacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay
ChEMBL 534 7 2 7 5.3 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2015.03.083
CHEMBL3290096 118919 0 None -1 2 Rat 6.8 pKi = 6.8 Binding
Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding AssayDisplacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay
ChEMBL 534 7 2 7 5.3 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2015.03.083
155560504 183197 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL 873 24 13 10 -0.5 CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00122
CHEMBL4567672 183197 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL 873 24 13 10 -0.5 CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00122
CHEMBL4596126 183197 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL 873 24 13 10 -0.5 CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00122
56669202 69972 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 780 19 7 8 3.0 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL1790463 69972 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 780 19 7 8 3.0 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL266571 217468 2 None -2041 2 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
56658940 69977 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 716 19 7 8 2.2 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL1790472 69977 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 716 19 7 8 2.2 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
10056201 170301 8 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-neurotensin from NTS1 receptor (unknown origin) after 20 mins by liquid scintillation counting analysisDisplacement of [3H]-neurotensin from NTS1 receptor (unknown origin) after 20 mins by liquid scintillation counting analysis
ChEMBL 809 15 11 9 -0.6 CC(C)C[C@H](NC(=O)[C@@H]1CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4202627 170301 8 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-neurotensin from NTS1 receptor (unknown origin) after 20 mins by liquid scintillation counting analysisDisplacement of [3H]-neurotensin from NTS1 receptor (unknown origin) after 20 mins by liquid scintillation counting analysis
ChEMBL 809 15 11 9 -0.6 CC(C)C[C@H](NC(=O)[C@@H]1CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4528239 221519 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N(C)[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2008.08.051
CHEMBL508130 221519 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N(C)[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2008.08.051
145976898 170611 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 841 29 9 10 2.2 C=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)c(CC=C)c1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b00175
CHEMBL4206391 170611 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 841 29 9 10 2.2 C=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)c(CC=C)c1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b00175
162677029 190283 0 None 4 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1632 50 23 21 -3.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4799695 190283 0 None 4 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1632 50 23 21 -3.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
1580 10437 46 None -1 4 Rat 8.7 pKi = 8.7 Binding
Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2014.11.047
5311451 10437 46 None -1 4 Rat 8.7 pKi = 8.7 Binding
Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2014.11.047
CHEMBL3040381 10437 46 None -1 4 Rat 8.7 pKi = 8.7 Binding
Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assayDisplacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assay
ChEMBL 685 13 2 8 5.7 COc1cccc(c1c1cc(nn1c1ccc(cc1C(C)C)C(=O)N(CCCN(C)C)C)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmcl.2014.11.047
44572616 195561 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 801 24 12 9 -0.0 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
CHEMBL505695 195561 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 801 24 12 9 -0.0 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
1574 9585 20 None -5 6 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells
ChEMBL None None None None 10.1016/j.bmc.2008.08.051
1579 9585 20 None -5 6 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells
ChEMBL None None None None 10.1016/j.bmc.2008.08.051
25077406 9585 20 None -5 6 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells
ChEMBL None None None None 10.1016/j.bmc.2008.08.051
3830 9585 20 None -5 6 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells
ChEMBL None None None None 10.1016/j.bmc.2008.08.051
CHEMBL407196 9585 20 None -5 6 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells
ChEMBL None None None None 10.1016/j.bmc.2008.08.051
CHEMBL172473 215632 0 None - 1 Mouse 8.7 pKi = 8.7 Binding
Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80698-8
155547078 183315 0 None -3 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1456 42 15 15 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4534768 183315 0 None -3 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1456 42 15 15 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4597104 183315 0 None -3 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1456 42 15 15 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
162651256 187113 0 None 2 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1630 48 23 21 -4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4751221 187113 0 None 2 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1630 48 23 21 -4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
162674076 189864 0 None 3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1629 48 22 20 -2.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4794420 189864 0 None 3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1629 48 22 20 -2.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
44578945 195672 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells
ChEMBL 881 22 13 10 -0.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)NC1(C(=O)O)C2CC3CC(C2)CC1C3 10.1016/j.bmc.2008.08.051
CHEMBL507382 195672 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells
ChEMBL 881 22 13 10 -0.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)NC1(C(=O)O)C2CC3CC(C2)CC1C3 10.1016/j.bmc.2008.08.051
168274909 197028 0 None -2 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assayDisplacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assay
ChEMBL 995 31 15 14 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSCCN)C(=O)O 10.1016/j.bmc.2022.116720
CHEMBL5175252 197028 0 None -2 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assayDisplacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assay
ChEMBL 995 31 15 14 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSCCN)C(=O)O 10.1016/j.bmc.2022.116720
155547078 183315 0 None -3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1456 42 15 15 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4534768 183315 0 None -3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1456 42 15 15 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4597104 183315 0 None -3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1456 42 15 15 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
155569726 183003 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1577 47 15 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4584647 183003 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1577 47 15 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4594647 183003 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1577 47 15 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
119192 9259 54 None 3 9 Rat 8.6 pKi = 8.6 Binding
Displacement of [125I]NT from rat NTR1 transfected in mouse LTK cellsDisplacement of [125I]NT from rat NTR1 transfected in mouse LTK cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2013.04.075
1582 9259 54 None 3 9 Rat 8.6 pKi = 8.6 Binding
Displacement of [125I]NT from rat NTR1 transfected in mouse LTK cellsDisplacement of [125I]NT from rat NTR1 transfected in mouse LTK cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2013.04.075
CHEMBL506981 9259 54 None 3 9 Rat 8.6 pKi = 8.6 Binding
Displacement of [125I]NT from rat NTR1 transfected in mouse LTK cellsDisplacement of [125I]NT from rat NTR1 transfected in mouse LTK cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2013.04.075
DB06455 9259 54 None 3 9 Rat 8.6 pKi = 8.6 Binding
Displacement of [125I]NT from rat NTR1 transfected in mouse LTK cellsDisplacement of [125I]NT from rat NTR1 transfected in mouse LTK cells
ChEMBL 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 10.1016/j.bmc.2013.04.075
155569719 183151 0 None 2 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1577 47 15 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2ccccc21)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4592541 183151 0 None 2 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1577 47 15 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2ccccc21)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4595797 183151 0 None 2 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1577 47 15 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2ccccc21)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL258221 217295 17 None 2 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm200006c
162674795 190236 0 None 3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1580 48 22 20 -4.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4799000 190236 0 None 3 2 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1580 48 22 20 -4.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
162655533 187560 0 None 1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1646 51 24 21 -3.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4756326 187560 0 None 1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1646 51 24 21 -3.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
44572622 179476 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 787 23 10 9 1.2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL450258 179476 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 787 23 10 9 1.2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
44572619 178997 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 817 24 11 10 0.4 CN[C@@H](CCCCN)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
CHEMBL447400 178997 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 817 24 11 10 0.4 CN[C@@H](CCCCN)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
CHEMBL174438 215635 0 None - 1 Mouse 6.7 pKi = 6.7 Binding
Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)O 10.1016/S0960-894X(00)80698-8
162658930 187804 0 None 3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1630 48 23 21 -4.4 CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4759247 187804 0 None 3 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1630 48 23 21 -4.4 CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL253527 217289 0 None -12 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CCc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
56658939 69976 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 1028 25 7 8 5.5 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL1790469 69976 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 1028 25 7 8 5.5 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL1790473 215670 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL501956 220926 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@](C)(N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/jm801072v
56662311 69975 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 792 20 7 8 3.8 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)c1ccc(C(C)(C)C)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL1790467 69975 0 None - 1 Rat 6.7 pKi = 6.7 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 792 20 7 8 3.8 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)c1ccc(C(C)(C)C)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL1766931 215647 0 None 2 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
56681744 70107 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Tested for binding affinity against Neurotensin receptorTested for binding affinity against Neurotensin receptor
ChEMBL 730 18 7 8 5.2 CC[C@H](C)[C@H](NC(=O)N(Cc1ccc(O)cc1)c1cccc(NC(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)c1F)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/0960-894X(95)00195-Y
CHEMBL1794000 70107 0 None - 1 Rat 5.7 pKi = 5.7 Binding
Tested for binding affinity against Neurotensin receptorTested for binding affinity against Neurotensin receptor
ChEMBL 730 18 7 8 5.2 CC[C@H](C)[C@H](NC(=O)N(Cc1ccc(O)cc1)c1cccc(NC(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)c1F)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/0960-894X(95)00195-Y
54585990 68066 0 None -46 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](CC(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N 10.1021/jm200006c
CHEMBL1766938 68066 0 None -46 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](CC(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N 10.1021/jm200006c
CHEMBL1766925 215641 0 None 2 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm200006c
CHEMBL1766942 215653 0 None -131 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(CCc1ccccc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL265671 217438 0 None - 1 Mouse 7.6 pKi = 7.6 Binding
Binding affinity for Neurotensin ReceptorBinding affinity for Neurotensin Receptor
ChEMBL None None None CCOC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NCCCCCCN)C(C)(C)C 10.1016/0960-894X(95)00155-M
168291832 198641 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL 881 27 14 13 -1.8 CC(C)C[C@H](NC(=O)[C@H](CSSCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O 10.1016/j.bmc.2022.116720
CHEMBL5199274 198641 0 None 1 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL 881 27 14 13 -1.8 CC(C)C[C@H](NC(=O)[C@H](CSSCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O 10.1016/j.bmc.2022.116720
CHEMBL1766825 215638 0 None -3235 2 Human 4.6 pKi = 4.6 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
56661317 70108 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Tested for binding affinity against Neurotensin receptorTested for binding affinity against Neurotensin receptor
ChEMBL 711 19 7 8 4.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)c1cccc(NC(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)c1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/0960-894X(95)00195-Y
CHEMBL1794002 70108 0 None - 1 Rat 7.5 pKi = 7.5 Binding
Tested for binding affinity against Neurotensin receptorTested for binding affinity against Neurotensin receptor
ChEMBL 711 19 7 8 4.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)c1cccc(NC(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)c1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/0960-894X(95)00195-Y
56669201 69969 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 858 24 9 10 1.9 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CCCCC1SCC2NC(=O)NC21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL1790457 69969 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 858 24 9 10 1.9 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CCCCC1SCC2NC(=O)NC21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL8899 222677 0 None - 1 Rat 5.5 pKi = 5.5 Binding
Neurotensin receptor binding affinity by displacement of [3H]- neurotensinNeurotensin receptor binding affinity by displacement of [3H]- neurotensin
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NNCC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80282-6
1574 9585 20 None -5 6 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL None None None None 10.1021/acs.jmedchem.0c01726
1579 9585 20 None -5 6 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL None None None None 10.1021/acs.jmedchem.0c01726
25077406 9585 20 None -5 6 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL None None None None 10.1021/acs.jmedchem.0c01726
3830 9585 20 None -5 6 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL None None None None 10.1021/acs.jmedchem.0c01726
CHEMBL407196 9585 20 None -5 6 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL None None None None 10.1021/acs.jmedchem.0c01726
54582127 68064 0 None 4 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)C[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL1766936 68064 0 None 4 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)C[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
155569734 183473 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4566971 183473 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4598410 183473 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1657 48 16 20 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)O)ccc21)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
44264252 210127 0 None - 1 Mouse 8.4 pKi = 8.4 Binding
Binding affinity for Neurotensin ReceptorBinding affinity for Neurotensin Receptor
ChEMBL 711 20 7 7 3.2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)C(CCCCN)CCCCN)C(C)(C)C)C(=O)O 10.1016/0960-894X(95)00155-M
CHEMBL6505 210127 0 None - 1 Mouse 8.4 pKi = 8.4 Binding
Binding affinity for Neurotensin ReceptorBinding affinity for Neurotensin Receptor
ChEMBL 711 20 7 7 3.2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)C(CCCCN)CCCCN)C(C)(C)C)C(=O)O 10.1016/0960-894X(95)00155-M
145975472 170753 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity to NTS1 (unknown origin)Binding affinity to NTS1 (unknown origin)
ChEMBL 742 14 8 9 0.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC1=O 10.1021/acs.jmedchem.0c01726
CHEMBL4207932 170753 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity to NTS1 (unknown origin)Binding affinity to NTS1 (unknown origin)
ChEMBL 742 14 8 9 0.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC1=O 10.1021/acs.jmedchem.0c01726
145975472 170753 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity to NTS1 receptor (unknown origin)Binding affinity to NTS1 receptor (unknown origin)
ChEMBL 742 14 8 9 0.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC1=O 10.1021/acs.jmedchem.8b00175
CHEMBL4207932 170753 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity to NTS1 receptor (unknown origin)Binding affinity to NTS1 receptor (unknown origin)
ChEMBL 742 14 8 9 0.7 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC1=O 10.1021/acs.jmedchem.8b00175
CHEMBL2369509 216409 0 None -5 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)N(CC(=O)N[C@@H](CC(C)C)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN 10.1021/jm200006c
CHEMBL254770 217291 0 None -30 2 Human 4.5 pKi = 4.5 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(Cc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL445035 220716 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/jm801072v
145977513 170345 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 827 13 9 10 1.8 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4203162 170345 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 827 13 9 10 1.8 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL6562 222641 0 None - 1 Mouse 7.5 pKi = 7.5 Binding
Binding affinity for Neurotensin ReceptorBinding affinity for Neurotensin Receptor
ChEMBL None None None CCOC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC[C@@H](N)CCCCN)C(C)(C)C 10.1016/0960-894X(95)00155-M
CHEMBL1766946 215657 0 None -7413 2 Human 4.5 pKi = 4.5 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
90644398 118928 0 None -22 2 Rat 5.5 pKi = 5.5 Binding
Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding AssayDisplacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay
ChEMBL 467 7 2 6 4.2 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1016/j.bmcl.2015.03.083
CHEMBL3290105 118928 0 None -22 2 Rat 5.5 pKi = 5.5 Binding
Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding AssayDisplacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay
ChEMBL 467 7 2 6 4.2 COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)CCCCC2)nn1-c1ccc(F)cc1 10.1016/j.bmcl.2015.03.083
145967420 171059 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 997 16 8 13 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCN(S(=O)(=O)c2ccccc2[N+](=O)[O-])CCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4211866 171059 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 997 16 8 13 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCN(S(=O)(=O)c2ccccc2[N+](=O)[O-])CCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL2369509 216409 0 None -5 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)N(CC(=O)N[C@@H](CC(C)C)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN 10.1021/jm200006c
44157038 195718 16 None 1 3 Human 5.5 pKi = 5.5 Binding
Inhibition of NTS1 receptor (unknown origin)Inhibition of NTS1 receptor (unknown origin)
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1cc(C(=O)N[C@@H](CC(C)C)C(=O)O)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
CHEMBL508044 195718 16 None 1 3 Human 5.5 pKi = 5.5 Binding
Inhibition of NTS1 receptor (unknown origin)Inhibition of NTS1 receptor (unknown origin)
ChEMBL 522 9 2 7 5.0 COc1cccc(OC)c1-c1cc(C(=O)N[C@@H](CC(C)C)C(=O)O)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2013.11.026
162660690 188106 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-neurotensin from NTS1 in human HT-29 cell membrane incubated for 20 mins by liquid scintillation counter analysisDisplacement of [3H]-neurotensin from NTS1 in human HT-29 cell membrane incubated for 20 mins by liquid scintillation counter analysis
ChEMBL 880 15 11 10 -1.1 CC(C)C[C@H](NC(=O)[C@@H]1CCC(=O)NCC(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N2CCCC2C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4762781 188106 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-neurotensin from NTS1 in human HT-29 cell membrane incubated for 20 mins by liquid scintillation counter analysisDisplacement of [3H]-neurotensin from NTS1 in human HT-29 cell membrane incubated for 20 mins by liquid scintillation counter analysis
ChEMBL 880 15 11 10 -1.1 CC(C)C[C@H](NC(=O)[C@@H]1CCC(=O)NCC(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N2CCCC2C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.0c01726
10463386 171147 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-neurotensin from NTS1 receptor (unknown origin) after 20 mins by liquid scintillation counting analysisDisplacement of [3H]-neurotensin from NTS1 receptor (unknown origin) after 20 mins by liquid scintillation counting analysis
ChEMBL 880 15 11 10 -1.1 CC(C)C[C@H](NC(=O)[C@@H]1CCC(=O)NCC(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4212835 171147 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-neurotensin from NTS1 receptor (unknown origin) after 20 mins by liquid scintillation counting analysisDisplacement of [3H]-neurotensin from NTS1 receptor (unknown origin) after 20 mins by liquid scintillation counting analysis
ChEMBL 880 15 11 10 -1.1 CC(C)C[C@H](NC(=O)[C@@H]1CCC(=O)NCC(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL1766940 215651 0 None -2 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N(CC(=O)O)CC(C)C 10.1021/jm200006c
44265535 174246 0 None - 1 Rat 5.4 pKi = 5.4 Binding
Neurotensin receptor binding affinity by displacement of [3H]- neurotensinNeurotensin receptor binding affinity by displacement of [3H]- neurotensin
ChEMBL 853 26 9 12 2.5 CC[C@H](C)[C@H](NNCC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1NCC(=O)[C@H](CCCCN)NC(=O)C12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80282-6
CHEMBL429903 174246 0 None - 1 Rat 5.4 pKi = 5.4 Binding
Neurotensin receptor binding affinity by displacement of [3H]- neurotensinNeurotensin receptor binding affinity by displacement of [3H]- neurotensin
ChEMBL 853 26 9 12 2.5 CC[C@H](C)[C@H](NNCC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1NCC(=O)[C@H](CCCCN)NC(=O)C12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80282-6
CHEMBL173256 215634 0 None - 1 Mouse 5.4 pKi = 5.4 Binding
Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)O 10.1016/S0960-894X(00)80698-8
155548876 183077 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 940 26 14 11 0.0 C#CCCCCNC(=O)NC(=N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00388
CHEMBL4538956 183077 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 940 26 14 11 0.0 C#CCCCCNC(=O)NC(=N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00388
CHEMBL4595185 183077 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 940 26 14 11 0.0 C#CCCCCNC(=O)NC(=N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00388
145947110 174408 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL4299304 174408 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL4301523 174408 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
127030965 145981 0 None -5 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
155559776 145981 0 None -5 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL3787709 145981 0 None -5 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4564746 145981 0 None -5 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
155548876 183077 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 940 26 14 11 0.0 C#CCCCCNC(=O)NC(=N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00388
CHEMBL4538956 183077 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 940 26 14 11 0.0 C#CCCCCNC(=O)NC(=N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00388
CHEMBL4595185 183077 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 940 26 14 11 0.0 C#CCCCCNC(=O)NC(=N)NCCC[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00388
155569726 183003 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1577 47 15 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4584647 183003 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1577 47 15 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4594647 183003 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1577 47 15 18 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCOCCOCCNC(=O)CCCCCN1/C(=C/C=C/C=C/C2=[N+](CCCCS(=O)(=O)[O-])c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
44572620 180637 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human NTR1Binding affinity to human NTR1
ChEMBL 828 24 10 10 1.5 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@H](CCCCN)N=[N+]=[N-])C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL453924 180637 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to human NTR1Binding affinity to human NTR1
ChEMBL 828 24 10 10 1.5 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@H](CCCCN)N=[N+]=[N-])C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL172313 215631 0 None 14 3 Mouse 8.4 pKi = 8.4 Binding
Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonatal mouse whole brain (minus cerebellum)
ChEMBL None None None None 10.1016/S0960-894X(00)80698-8
CHEMBL1766923 215639 0 None 12 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm200006c
CHEMBL501575 220918 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@](C)(N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm801072v
168283408 197670 0 None -3 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL 1009 32 15 14 -0.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCSSCCN)C(=O)O 10.1016/j.bmc.2022.116720
CHEMBL5184967 197670 0 None -3 2 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL 1009 32 15 14 -0.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCSSCCN)C(=O)O 10.1016/j.bmc.2022.116720
10101832 187066 0 None - 1 Mouse 6.4 pKi = 6.4 Binding
Displacement of [3H]-neurotensin from NTS1 in mouse brain membrane incubated for 30 mins by liquid scintillation counter analysisDisplacement of [3H]-neurotensin from NTS1 in mouse brain membrane incubated for 30 mins by liquid scintillation counter analysis
ChEMBL 793 12 10 8 0.6 CC(C)C[C@@H]1NC(=O)[C@H](C(C)(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC1=O 10.1021/acs.jmedchem.0c01726
CHEMBL4750764 187066 0 None - 1 Mouse 6.4 pKi = 6.4 Binding
Displacement of [3H]-neurotensin from NTS1 in mouse brain membrane incubated for 30 mins by liquid scintillation counter analysisDisplacement of [3H]-neurotensin from NTS1 in mouse brain membrane incubated for 30 mins by liquid scintillation counter analysis
ChEMBL 793 12 10 8 0.6 CC(C)C[C@@H]1NC(=O)[C@H](C(C)(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC1=O 10.1021/acs.jmedchem.0c01726
CHEMBL2310906 216278 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]NT(8-13) from human NTR1 extracellular loop 1 I329G mutant expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from human NTR1 extracellular loop 1 I329G mutant expressed in HEK293 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2008.08.051
56665745 69974 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 737 20 7 9 1.9 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL1790466 69974 0 None - 1 Rat 6.4 pKi = 6.4 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 737 20 7 9 1.9 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
145970755 171559 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4218115 171559 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
162646717 186387 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1671 50 23 21 -4.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(N)=O 10.1021/acs.jmedchem.0c01726
CHEMBL4742361 186387 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1671 50 23 21 -4.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(N)=O 10.1021/acs.jmedchem.0c01726
CHEMBL268600 217539 0 None - 1 Mouse 6.4 pKi = 6.4 Binding
Binding affinity for Neurotensin ReceptorBinding affinity for Neurotensin Receptor
ChEMBL None None None CCOC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC[C@@H](N)CCCN=C(N)N)C(C)(C)C 10.1016/0960-894X(95)00155-M
101040509 171492 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor (end Leu 194 residues) expressed in CHO cellsDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor (end Leu 194 residues) expressed in CHO cells
ChEMBL 756 13 8 8 1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(cc2)OCCCCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4217340 171492 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor (end Leu 194 residues) expressed in CHO cellsDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor (end Leu 194 residues) expressed in CHO cells
ChEMBL 756 13 8 8 1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(cc2)OCCCCCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
162661419 188666 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO cell membranesDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO cell membranes
ChEMBL 756 13 8 8 1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(cc2)OCCCCCC(=O)N[C@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4779035 188666 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO cell membranesDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO cell membranes
ChEMBL 756 13 8 8 1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1Cc2ccc(cc2)OCCCCCC(=O)N[C@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
137651867 164027 0 None 1 2 Human 6.3 pKi = 6.3 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysis
ChEMBL 734 24 9 10 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.6b01848
CHEMBL4076517 164027 0 None 1 2 Human 6.3 pKi = 6.3 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysis
ChEMBL 734 24 9 10 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.6b01848
44447826 103730 0 None 4 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)C[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL266230 103730 0 None 4 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)C[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL1766941 215652 0 None -1230 2 Human 4.3 pKi = 4.3 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(OC)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
168291832 198641 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assayDisplacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assay
ChEMBL 881 27 14 13 -1.8 CC(C)C[C@H](NC(=O)[C@H](CSSCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O 10.1016/j.bmc.2022.116720
CHEMBL5199274 198641 0 None 1 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assayDisplacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assay
ChEMBL 881 27 14 13 -1.8 CC(C)C[C@H](NC(=O)[C@H](CSSCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O 10.1016/j.bmc.2022.116720
168269036 196793 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assayDisplacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assay
ChEMBL 895 28 14 13 -1.4 CC(C)C[C@H](NC(=O)[C@@H](CCSSCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O 10.1016/j.bmc.2022.116720
CHEMBL5171551 196793 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Displacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assayDisplacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assay
ChEMBL 895 28 14 13 -1.4 CC(C)C[C@H](NC(=O)[C@@H](CCSSCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O 10.1016/j.bmc.2022.116720
44572620 180637 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 828 24 10 10 1.5 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@H](CCCCN)N=[N+]=[N-])C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL453924 180637 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 828 24 10 10 1.5 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@H](CCCCN)N=[N+]=[N-])C(C)(C)C)C(=O)O 10.1021/jm801072v
155511768 176391 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 1924 44 18 25 5.4 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCc1cn(CCCNC(=O)CCCCCN2/C(=C/C=C/C=C/C3=[N+](C)c4ccc5c(S(=O)(=O)[O-])cc(S(=O)(=O)O)cc5c4C3(C)C)C(C)(C)c3c2ccc2c(S(=O)(=O)O)cc(S(=O)(=O)O)cc32)nn1)C(C)(C)C)C(=O)O 10.1021/acsmedchemlett.9b00388
CHEMBL4436580 176391 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 1924 44 18 25 5.4 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCc1cn(CCCNC(=O)CCCCCN2/C(=C/C=C/C=C/C3=[N+](C)c4ccc5c(S(=O)(=O)[O-])cc(S(=O)(=O)O)cc5c4C3(C)C)C(C)(C)c3c2ccc2c(S(=O)(=O)O)cc(S(=O)(=O)O)cc32)nn1)C(C)(C)C)C(=O)O 10.1021/acsmedchemlett.9b00388
155511768 176391 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 1924 44 18 25 5.4 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCc1cn(CCCNC(=O)CCCCCN2/C(=C/C=C/C=C/C3=[N+](C)c4ccc5c(S(=O)(=O)[O-])cc(S(=O)(=O)O)cc5c4C3(C)C)C(C)(C)c3c2ccc2c(S(=O)(=O)O)cc(S(=O)(=O)O)cc32)nn1)C(C)(C)C)C(=O)O 10.1021/acsmedchemlett.9b00388
CHEMBL4436580 176391 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 1924 44 18 25 5.4 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)NC(=O)NCCCCc1cn(CCCNC(=O)CCCCCN2/C(=C/C=C/C=C/C3=[N+](C)c4ccc5c(S(=O)(=O)[O-])cc(S(=O)(=O)O)cc5c4C3(C)C)C(C)(C)c3c2ccc2c(S(=O)(=O)O)cc(S(=O)(=O)O)cc32)nn1)C(C)(C)C)C(=O)O 10.1021/acsmedchemlett.9b00388
168274909 197028 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL 995 31 15 14 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSCCN)C(=O)O 10.1016/j.bmc.2022.116720
CHEMBL5175252 197028 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assayDisplacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assay
ChEMBL 995 31 15 14 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSCCN)C(=O)O 10.1016/j.bmc.2022.116720
CHEMBL2310906 216278 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from wild type human NTR1 expressed in HEK293 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2008.08.051
CHEMBL1790470 215669 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
73356042 96131 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 782 21 7 8 3.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CC1CCC2CCCC21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL2369587 96131 0 None - 1 Rat 6.3 pKi = 6.3 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 782 21 7 8 3.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CC1CCC2CCCC21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
44581036 194679 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHOK1 cells after 60 mins by beta plate liquid scintillation counterDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHOK1 cells after 60 mins by beta plate liquid scintillation counter
ChEMBL 494 9 3 6 3.6 CC(C)C[C@@H](NC(=O)Cn1ccc2cc(NS(=O)(=O)c3cccc4cccnc34)ccc21)C(=O)O 10.1016/j.bmcl.2008.09.075
CHEMBL496585 194679 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHOK1 cells after 60 mins by beta plate liquid scintillation counterDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHOK1 cells after 60 mins by beta plate liquid scintillation counter
ChEMBL 494 9 3 6 3.6 CC(C)C[C@@H](NC(=O)Cn1ccc2cc(NS(=O)(=O)c3cccc4cccnc34)ccc21)C(=O)O 10.1016/j.bmcl.2008.09.075
145966776 171215 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 782 13 7 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCCC(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4213725 171215 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 782 13 7 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCCCCC(=O)N[C@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
137646112 164698 0 None -21 2 Human 5.2 pKi = 5.2 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysis
ChEMBL 726 26 9 10 -0.2 CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.6b01848
CHEMBL4084378 164698 0 None -21 2 Human 5.2 pKi = 5.2 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysis
ChEMBL 726 26 9 10 -0.2 CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.6b01848
44265532 165233 0 None - 1 Rat 5.2 pKi = 5.2 Binding
Neurotensin receptor binding affinity by displacement of [3H]- neurotensinNeurotensin receptor binding affinity by displacement of [3H]- neurotensin
ChEMBL 824 23 8 10 2.9 CC[C@H](C)[C@H](NNCC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80282-6
CHEMBL409061 165233 0 None - 1 Rat 5.2 pKi = 5.2 Binding
Neurotensin receptor binding affinity by displacement of [3H]- neurotensinNeurotensin receptor binding affinity by displacement of [3H]- neurotensin
ChEMBL 824 23 8 10 2.9 CC[C@H](C)[C@H](NNCC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80282-6
162667468 189335 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1615 46 22 20 -3.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4787611 189335 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1615 46 22 20 -3.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL380726 219052 0 None - 1 Mouse 7.2 pKi = 7.2 Binding
Binding affinity for Neurotensin ReceptorBinding affinity for Neurotensin Receptor
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(C)(C)C)C(=O)O 10.1016/0960-894X(95)00155-M
CHEMBL4436458 220940 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL None None None CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)N(C)C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N 10.1021/acsmedchemlett.9b00122
CHEMBL503059 220940 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL None None None CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)N(C)C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N 10.1021/acsmedchemlett.9b00122
CHEMBL8857 222676 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL8857 222676 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Neurotensin receptor binding affinity by displacement of [3H]- neurotensinNeurotensin receptor binding affinity by displacement of [3H]- neurotensin
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80282-6
44572627 195064 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 796 22 10 8 1.6 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CCCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL500173 195064 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 796 22 10 8 1.6 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CCCCNC(=N)N)C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL500734 220902 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL None None None CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
145976418 170665 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 798 13 8 9 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCCCC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4206981 170665 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 798 13 8 9 2.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCCCC(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
137660279 166147 0 None -9 2 Human 6.2 pKi = 6.2 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysis
ChEMBL 756 26 9 10 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@H](C[Si](C)(C)C)C(=O)O 10.1021/acs.jmedchem.6b01848
CHEMBL4100456 166147 0 None -9 2 Human 6.2 pKi = 6.2 Binding
Displacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysisDisplacement of 125I-[Tyr3]-NT from human NTS1 receptor expressed in CHOK1 cell membranes after 30 mins by gamma counting analysis
ChEMBL 756 26 9 10 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@H](C[Si](C)(C)C)C(=O)O 10.1021/acs.jmedchem.6b01848
56672658 69971 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 730 20 7 8 2.6 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL1790461 69971 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 730 20 7 8 2.6 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
1570 8908 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Neurotensin receptor binding affinity by displacement of [3H]- neurotensinNeurotensin receptor binding affinity by displacement of [3H]- neurotensin
ChEMBL None None None None 10.1016/S0960-894X(00)80282-6
164415 8908 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Neurotensin receptor binding affinity by displacement of [3H]- neurotensinNeurotensin receptor binding affinity by displacement of [3H]- neurotensin
ChEMBL None None None None 10.1016/S0960-894X(00)80282-6
CHEMBL8454 8908 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Neurotensin receptor binding affinity by displacement of [3H]- neurotensinNeurotensin receptor binding affinity by displacement of [3H]- neurotensin
ChEMBL None None None None 10.1016/S0960-894X(00)80282-6
1570 8908 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL None None None None 10.1016/S0960-894X(01)81014-3
164415 8908 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL None None None None 10.1016/S0960-894X(01)81014-3
CHEMBL8454 8908 0 None - 1 Rat 6.2 pKi = 6.2 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL None None None None 10.1016/S0960-894X(01)81014-3
168283408 197670 0 None -3 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assayDisplacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assay
ChEMBL 1009 32 15 14 -0.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCSSCCN)C(=O)O 10.1016/j.bmc.2022.116720
CHEMBL5184967 197670 0 None -3 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assayDisplacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assay
ChEMBL 1009 32 15 14 -0.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCSSCCN)C(=O)O 10.1016/j.bmc.2022.116720
127030965 145981 0 None -5 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
155559776 145981 0 None -5 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL3787709 145981 0 None -5 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
CHEMBL4564746 145981 0 None -5 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysisDisplacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation counter analysis
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00462
145947110 174408 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL4299304 174408 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL4301523 174408 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from human NTSR1 transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
ChEMBL 1396 38 14 12 6.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(=O)N[C@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL1766930 215646 0 None -1 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL2310906 216278 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]NT(8-13) from human NTR1 extracellular loop 1 YIS328-330AAA mutant expressed in HEK293 cellsDisplacement of [3H]NT(8-13) from human NTR1 extracellular loop 1 YIS328-330AAA mutant expressed in HEK293 cells
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/j.bmc.2008.08.051
118729838 124721 0 None -51 2 Rat 5.1 pKi = 5.1 Binding
Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding AssayDisplacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay
ChEMBL 534 7 2 7 5.7 COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2015.03.083
CHEMBL3403505 124721 0 None -51 2 Rat 5.1 pKi = 5.1 Binding
Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding AssayDisplacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay
ChEMBL 534 7 2 7 5.7 COc1cccc(OC)c1-c1cc(NC(=O)C2(C(=O)O)CCCCC2)nn1-c1ccnc2cc(Cl)ccc12 10.1016/j.bmcl.2015.03.083
56675174 70094 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Tested for binding affinity against Neurotensin receptorTested for binding affinity against Neurotensin receptor
ChEMBL 698 19 7 8 5.6 CC[C@H](C)[C@H](NC(=O)N(Cc1ccc(O)cc1)c1cccc(NC[C@H](CCCCN)NC(=O)OC(C)(C)C)c1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/0960-894X(95)00195-Y
CHEMBL1793833 70094 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Tested for binding affinity against Neurotensin receptorTested for binding affinity against Neurotensin receptor
ChEMBL 698 19 7 8 5.6 CC[C@H](C)[C@H](NC(=O)N(Cc1ccc(O)cc1)c1cccc(NC[C@H](CCCCN)NC(=O)OC(C)(C)C)c1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/0960-894X(95)00195-Y
162653994 187327 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1587 46 20 20 -2.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
CHEMBL4753810 187327 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysisDisplacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis
ChEMBL 1587 46 20 20 -2.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.0c01726
10440473 190026 0 None - 1 Mouse 6.1 pKi = 6.1 Binding
Displacement of [3H]-neurotensin from NTS1 in mouse brain membrane incubated for 30 mins by liquid scintillation counter analysisDisplacement of [3H]-neurotensin from NTS1 in mouse brain membrane incubated for 30 mins by liquid scintillation counter analysis
ChEMBL 823 14 11 9 -0.3 CN[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CCCCNC(=O)CC[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c01726
CHEMBL4796388 190026 0 None - 1 Mouse 6.1 pKi = 6.1 Binding
Displacement of [3H]-neurotensin from NTS1 in mouse brain membrane incubated for 30 mins by liquid scintillation counter analysisDisplacement of [3H]-neurotensin from NTS1 in mouse brain membrane incubated for 30 mins by liquid scintillation counter analysis
ChEMBL 823 14 11 9 -0.3 CN[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CCCCNC(=O)CC[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c01726
145964771 170974 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4210760 170974 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 813 13 9 10 1.4 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCNCCCC[C@@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
44572617 195576 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 803 23 11 10 0.2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@H](N)CCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL505906 195576 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]I-Tyr(3)NT from human NTR1Displacement of [125I]I-Tyr(3)NT from human NTR1
ChEMBL 803 23 11 10 0.2 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@H](N)CCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
54585023 68065 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)C[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL1766937 68065 0 None 5 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)C[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
54583075 68067 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](CC(=O)O)CC(C)C 10.1021/jm200006c
CHEMBL1766939 68067 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 831 25 13 10 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@H](CC(=O)O)CC(C)C 10.1021/jm200006c
CHEMBL1766944 215655 0 None -11748 2 Human 4.1 pKi = 4.1 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
CHEMBL427656 220140 0 None - 1 Rat 7.1 pKi = 7.1 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL427656 220140 0 None - 1 Rat 7.1 pKi = 7.1 Binding
Neurotensin receptor binding affinity by displacement of [3H]- neurotensinNeurotensin receptor binding affinity by displacement of [3H]- neurotensin
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(00)80282-6
10259838 189219 0 None - 1 Mouse 7.1 pKi = 7.1 Binding
Displacement of [3H]-neurotensin from NTS1 in mouse brain membrane incubated for 30 mins by liquid scintillation counter analysisDisplacement of [3H]-neurotensin from NTS1 in mouse brain membrane incubated for 30 mins by liquid scintillation counter analysis
ChEMBL 816 14 10 10 0.8 CN[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSSC(C)(C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c01726
CHEMBL4786197 189219 0 None - 1 Mouse 7.1 pKi = 7.1 Binding
Displacement of [3H]-neurotensin from NTS1 in mouse brain membrane incubated for 30 mins by liquid scintillation counter analysisDisplacement of [3H]-neurotensin from NTS1 in mouse brain membrane incubated for 30 mins by liquid scintillation counter analysis
ChEMBL 816 14 10 10 0.8 CN[C@@H](CCCNC(=N)N)C(=O)N[C@H]1CSSC(C)(C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c01726
CHEMBL1766945 215656 0 None -1905 2 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
54580109 68068 0 None -251 2 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 862 24 11 8 3.0 C=C(N[C@@H](CC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCCNC(=N)N 10.1021/jm200006c
CHEMBL1766947 68068 0 None -251 2 Human 5.1 pKi = 5.1 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL 862 24 11 8 3.0 C=C(N[C@@H](CC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)CCCNC(=N)N 10.1021/jm200006c
56658818 69973 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 812 21 7 8 4.2 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)c1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL1790465 69973 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Binding affinity against rat neurotensin receptor.Binding affinity against rat neurotensin receptor.
ChEMBL 812 21 7 8 4.2 CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)c1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/S0960-894X(01)81014-3
CHEMBL4528239 221519 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N(C)[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00122
CHEMBL508130 221519 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counterDisplacement of [3H]UR-MK300 from human NSTR1 in HT-29 cells incubated for 2 hrs by liquid scintillation counter
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N(C)[C@@H](CC(C)C)C(=O)O 10.1021/acsmedchemlett.9b00122
CHEMBL1766932 215648 0 None -6 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cellsDisplacement of [3H]neurotensin from human NTS1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/jm200006c
56681743 70106 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Tested for binding affinity against Neurotensin receptorTested for binding affinity against Neurotensin receptor
ChEMBL 714 18 6 7 5.5 CC[C@H](C)[C@H](NC(=O)N(Cc1ccc(F)cc1)c1cccc(NC(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)c1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/0960-894X(95)00195-Y
CHEMBL1793999 70106 0 None - 1 Rat 6.1 pKi = 6.1 Binding
Tested for binding affinity against Neurotensin receptorTested for binding affinity against Neurotensin receptor
ChEMBL 714 18 6 7 5.5 CC[C@H](C)[C@H](NC(=O)N(Cc1ccc(F)cc1)c1cccc(NC(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)c1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1016/0960-894X(95)00195-Y
155547102 183031 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 940 26 14 11 0.0 C#CCCCCNC(=O)NC(=N)NCCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00388
CHEMBL4533793 183031 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 940 26 14 11 0.0 C#CCCCCNC(=O)NC(=N)NCCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00388
CHEMBL4594880 183031 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 940 26 14 11 0.0 C#CCCCCNC(=O)NC(=N)NCCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00388
155513243 183180 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 954 27 14 11 0.3 C#CCCCCNC(=O)NC(=N)NCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00388
CHEMBL4438773 183180 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 954 27 14 11 0.3 C#CCCCCNC(=O)NC(=N)NCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00388
CHEMBL4595989 183180 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 954 27 14 11 0.3 C#CCCCCNC(=O)NC(=N)NCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00388
155547102 183031 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 940 26 14 11 0.0 C#CCCCCNC(=O)NC(=N)NCCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00388
CHEMBL4533793 183031 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 940 26 14 11 0.0 C#CCCCCNC(=O)NC(=N)NCCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00388
CHEMBL4594880 183031 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 940 26 14 11 0.0 C#CCCCCNC(=O)NC(=N)NCCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00388
155513243 183180 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 954 27 14 11 0.3 C#CCCCCNC(=O)NC(=N)NCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00388
CHEMBL4438773 183180 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 954 27 14 11 0.3 C#CCCCCNC(=O)NC(=N)NCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00388
CHEMBL4595989 183180 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting methodDisplacement of [3H]UR-MK300 from human NTS1R expressed in human HT-29 cells incubated for 2 hrs by scintillation counting method
ChEMBL 954 27 14 11 0.3 C#CCCCCNC(=O)NC(=N)NCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/acsmedchemlett.9b00388
44572621 195032 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity to human NTR1Binding affinity to human NTR1
ChEMBL 817 23 11 10 0.5 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@](C)(N)CCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
CHEMBL499673 195032 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity to human NTR1Binding affinity to human NTR1
ChEMBL 817 23 11 10 0.5 CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)C[C@@](C)(N)CCCCN)C(C)(C)C)C(=O)O 10.1021/jm801072v
145972052 171297 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 841 13 9 10 2.2 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL4214816 171297 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysisDisplacement of [125I]Tyr3-neurotensin from human NTS1 receptor expressed in CHOK1 cell membranes after 60 mins by gamma counting analysis
ChEMBL 841 13 9 10 2.2 CC[C@H](C)[C@H](NC(=O)[C@H]1Cc2ccc(O)c(c2)CC=CCCCNCCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N2CCC[C@H]2C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)O 10.1021/acs.jmedchem.8b00175
CHEMBL266571 217468 2 None -2041 2 Human 7.0 pKi = 7.0 Binding
Binding affinity to human NTR1Binding affinity to human NTR1
ChEMBL None None None CN[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)(C)C 10.1021/jm801072v
1574 9585 20 None -3 6 Rat 9.8 pKd None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12869647
1574 9585 20 None -3 6 Rat 9.8 pKd None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7746272
1579 9585 20 None -3 6 Rat 9.8 pKd None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12869647
1579 9585 20 None -3 6 Rat 9.8 pKd None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7746272
25077406 9585 20 None -3 6 Rat 9.8 pKd None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12869647
25077406 9585 20 None -3 6 Rat 9.8 pKd None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7746272
3830 9585 20 None -3 6 Rat 9.8 pKd None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12869647
3830 9585 20 None -3 6 Rat 9.8 pKd None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7746272
CHEMBL407196 9585 20 None -3 6 Rat 9.8 pKd None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12869647
CHEMBL407196 9585 20 None -3 6 Rat 9.8 pKd None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7746272
1574 9585 20 125I-Neurotensin 3 6 Mouse 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
1579 9585 20 125I-Neurotensin 3 6 Mouse 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
25077406 9585 20 125I-Neurotensin 3 6 Mouse 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
3830 9585 20 125I-Neurotensin 3 6 Mouse 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
CHEMBL407196 9585 20 125I-Neurotensin 3 6 Mouse 9.6 pKi = 9.6 Binding
NoneNone
PDSP KiDatabase None None None None None
21830793 98610 10 3H-8-OH-DPAT -66069 46 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 None
CHEMBL2413154 98610 10 3H-8-OH-DPAT -66069 46 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1 None
None 223145 0 125I-Neurotensin -588 2 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 420 4 1 3 4.9 CC1CN(CCC1(C2=CC=CC=C2)C(=O)O)C3CCC(CC3)(C#N)C4=CC=C(C=C4)F None
1570 8908 0 None - 1 Rat 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12869647
164415 8908 0 None - 1 Rat 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12869647
CHEMBL8454 8908 0 None - 1 Rat 10.0 pKi = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12869647
1569 8907 32 None 2 2 Human 5.3 pKi None 5.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
5311318 8907 32 None 2 2 Human 5.3 pKi None 5.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
CHEMBL415788 8907 32 None 2 2 Human 5.3 pKi None 5.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
1568 8904 0 None -31 2 Human 5.7 pKi None 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
1571 8909 0 None -10 2 Human 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
1581 10442 10 None 12 2 Rat 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 548 8 2 7 5.5 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)N[C@@H](C1CCCCC1)C(=O)O)OC 7746272
9915499 10442 10 None 12 2 Rat 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 548 8 2 7 5.5 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)N[C@@H](C1CCCCC1)C(=O)O)OC 7746272
CHEMBL461604 10442 10 None 12 2 Rat 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 548 8 2 7 5.5 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)N[C@@H](C1CCCCC1)C(=O)O)OC 7746272
119192 9259 54 None 3 9 Rat 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 7746272
119192 9259 54 None 3 9 Rat 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 9632698
1582 9259 54 None 3 9 Rat 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 7746272
1582 9259 54 None 3 9 Rat 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 9632698
CHEMBL506981 9259 54 None 3 9 Rat 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 7746272
CHEMBL506981 9259 54 None 3 9 Rat 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 9632698
DB06455 9259 54 None 3 9 Rat 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 7746272
DB06455 9259 54 None 3 9 Rat 8.3 pKi None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 9632698
119192 9259 54 None -3 9 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 11723247
1582 9259 54 None -3 9 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 11723247
CHEMBL506981 9259 54 None -3 9 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 11723247
DB06455 9259 54 None -3 9 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 586 7 2 7 5.8 COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC 11723247
1578 9547 0 None - 1 Rat 8.7 pKi None 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12869647
9940301 9547 0 None - 1 Rat 8.7 pKi None 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12869647
1572 8910 0 None 1 2 Human 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
5311320 8910 0 None 1 2 Human 8.8 pKi None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
1574 9585 20 None -5 6 Human 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10930533
1574 9585 20 None -5 6 Human 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
1579 9585 20 None -5 6 Human 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10930533
1579 9585 20 None -5 6 Human 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
25077406 9585 20 None -5 6 Human 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10930533
25077406 9585 20 None -5 6 Human 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
3830 9585 20 None -5 6 Human 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10930533
3830 9585 20 None -5 6 Human 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
CHEMBL407196 9585 20 None -5 6 Human 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10930533
CHEMBL407196 9585 20 None -5 6 Human 9.0 pKi None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11723247
1574 9585 20 None -3 6 Rat 9.1 pKi None 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10930533
1574 9585 20 None -3 6 Rat 9.1 pKi None 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12869647
1574 9585 20 None -3 6 Rat 9.1 pKi None 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9632698
1579 9585 20 None -3 6 Rat 9.1 pKi None 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10930533
1579 9585 20 None -3 6 Rat 9.1 pKi None 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12869647
1579 9585 20 None -3 6 Rat 9.1 pKi None 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9632698
25077406 9585 20 None -3 6 Rat 9.1 pKi None 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10930533
25077406 9585 20 None -3 6 Rat 9.1 pKi None 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12869647
25077406 9585 20 None -3 6 Rat 9.1 pKi None 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9632698
3830 9585 20 None -3 6 Rat 9.1 pKi None 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10930533
3830 9585 20 None -3 6 Rat 9.1 pKi None 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12869647
3830 9585 20 None -3 6 Rat 9.1 pKi None 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9632698
CHEMBL407196 9585 20 None -3 6 Rat 9.1 pKi None 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10930533
CHEMBL407196 9585 20 None -3 6 Rat 9.1 pKi None 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12869647
CHEMBL407196 9585 20 None -3 6 Rat 9.1 pKi None 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9632698
130482 8322 0 None - 1 Rat 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12869647
1566 8322 0 None - 1 Rat 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12869647
1567 8323 0 None - 1 Rat 9.8 pKi None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12869647