Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 16158474 | 213407 | None | 12 | Human | Functional | pEC50 | = | 10.1 | 10.1 | - | 1 | Agonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP levelAgonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP level |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2010.08.062 | ||||
| 16158474.0 | 213407 | None | 12 | Human | Functional | pEC50 | = | 10.1 | 10.1 | - | 1 | Agonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP levelAgonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP level |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2010.08.062 | ||||
| CHEMBL3039582 | 213407 | None | 12 | Human | Functional | pEC50 | = | 10.1 | 10.1 | - | 1 | Agonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP levelAgonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP level |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2010.08.062 | ||||
| DB09532 | 213407 | None | 12 | Human | Functional | pEC50 | = | 10.1 | 10.1 | - | 1 | Agonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP levelAgonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP level |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2010.08.062 | ||||
| CHEMBL1256314 | 211124 | None | 0 | Human | Functional | pEC50 | = | 10 | 10.0 | - | 1 | Agonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP levelAgonist activity at secretin receptor expressed in CHO cells assessed as increase of cAMP level |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N1)C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2010.08.062 | ||||
| 10356 | 3236 | None | 58 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 12 | 3 | Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 10 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 10 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit) |
ChEMBL | 520 | 6 | 1 | 8 | 6.9 | C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 | 10.1016/j.ejmech.2022.114642 | ||
| 5284329 | 3236 | None | 58 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 12 | 3 | Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 10 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 10 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit) |
ChEMBL | 520 | 6 | 1 | 8 | 6.9 | C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 | 10.1016/j.ejmech.2022.114642 | ||
| CHEMBL1221984 | 3236 | None | 58 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 12 | 3 | Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 10 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 10 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit) |
ChEMBL | 520 | 6 | 1 | 8 | 6.9 | C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 | 10.1016/j.ejmech.2022.114642 | ||
| 10356 | 3236 | None | 58 | Human | Functional | pEC50 | = | 7.2 | 7.2 | 12 | 3 | Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 1 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 1 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit) |
ChEMBL | 520 | 6 | 1 | 8 | 6.9 | C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 | 10.1016/j.ejmech.2022.114642 | ||
| 5284329 | 3236 | None | 58 | Human | Functional | pEC50 | = | 7.2 | 7.2 | 12 | 3 | Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 1 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 1 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit) |
ChEMBL | 520 | 6 | 1 | 8 | 6.9 | C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 | 10.1016/j.ejmech.2022.114642 | ||
| CHEMBL1221984 | 3236 | None | 58 | Human | Functional | pEC50 | = | 7.2 | 7.2 | 12 | 3 | Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 1 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 1 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit) |
ChEMBL | 520 | 6 | 1 | 8 | 6.9 | C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 | 10.1016/j.ejmech.2022.114642 | ||
| 172442653 | 195117 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay |
ChEMBL | 563 | 7 | 2 | 8 | 7.2 | O=C(O)c1cn(C2CCCCC2)c2nc(Oc3cccc4ccccc34)nc(Nc3ccc(N4CCOCC4)cc3)c12 | 10.1016/j.ejmech.2022.114642 | ||
| CHEMBL5396976 | 195117 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay |
ChEMBL | 563 | 7 | 2 | 8 | 7.2 | O=C(O)c1cn(C2CCCCC2)c2nc(Oc3cccc4ccccc34)nc(Nc3ccc(N4CCOCC4)cc3)c12 | 10.1016/j.ejmech.2022.114642 | ||
| 172468237 | 196888 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | Negative allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as decrease in SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayNegative allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as decrease in SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay |
ChEMBL | 561 | 6 | 1 | 6 | 9.8 | c1ccc2c(Oc3nc(Nc4ccc(-c5cccc6ccccc56)cc4)c4ncn(C5CCCCC5)c4n3)cccc2c1 | 10.1016/j.ejmech.2022.114642 | ||
| CHEMBL5434238 | 196888 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | Negative allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as decrease in SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayNegative allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as decrease in SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay |
ChEMBL | 561 | 6 | 1 | 6 | 9.8 | c1ccc2c(Oc3nc(Nc4ccc(-c5cccc6ccccc56)cc4)c4ncn(C5CCCCC5)c4n3)cccc2c1 | 10.1016/j.ejmech.2022.114642 | ||
| 172460766 | 196191 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay |
ChEMBL | 536 | 6 | 2 | 9 | 6.6 | Oc1ccc2c(Oc3nc(Nc4ccc(N5CCOCC5)cc4)c4ncn(C5CCCCC5)c4n3)cccc2c1 | 10.1016/j.ejmech.2022.114642 | ||
| CHEMBL5418444 | 196191 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay |
ChEMBL | 536 | 6 | 2 | 9 | 6.6 | Oc1ccc2c(Oc3nc(Nc4ccc(N5CCOCC5)cc4)c4ncn(C5CCCCC5)c4n3)cccc2c1 | 10.1016/j.ejmech.2022.114642 | ||
| 172460956 | 196427 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay |
ChEMBL | 536 | 6 | 2 | 9 | 6.6 | Oc1cc(N2CCOCC2)ccc1Nc1nc(Oc2cccc3ccccc23)nc2c1ncn2C1CCCCC1 | 10.1016/j.ejmech.2022.114642 | ||
| CHEMBL5423791 | 196427 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay |
ChEMBL | 536 | 6 | 2 | 9 | 6.6 | Oc1cc(N2CCOCC2)ccc1Nc1nc(Oc2cccc3ccccc23)nc2c1ncn2C1CCCCC1 | 10.1016/j.ejmech.2022.114642 | ||
| 172448245 | 195651 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay |
ChEMBL | 527 | 7 | 1 | 7 | 8.8 | c1ccc(Oc2ccc(Nc3nc(Oc4cccc5ccccc45)nc4c3ncn4C3CCCCC3)cc2)cc1 | 10.1016/j.ejmech.2022.114642 | ||
| CHEMBL5408063 | 195651 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay |
ChEMBL | 527 | 7 | 1 | 7 | 8.8 | c1ccc(Oc2ccc(Nc3nc(Oc4cccc5ccccc45)nc4c3ncn4C3CCCCC3)cc2)cc1 | 10.1016/j.ejmech.2022.114642 | ||
| 172463155 | 196665 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay |
ChEMBL | 536 | 6 | 2 | 9 | 5.8 | O[C@@H]1CCC[C@H](n2cnc3c(Nc4ccc(N5CCOCC5)cc4)nc(Oc4cccc5ccccc45)nc32)C1 | 10.1016/j.ejmech.2022.114642 | ||
| CHEMBL5429270 | 196665 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay |
ChEMBL | 536 | 6 | 2 | 9 | 5.8 | O[C@@H]1CCC[C@H](n2cnc3c(Nc4ccc(N5CCOCC5)cc4)nc(Oc4cccc5ccccc45)nc32)C1 | 10.1016/j.ejmech.2022.114642 | ||
| 10356 | 3236 | None | 58 | Human | Functional | pEC50 | = | 7.1 | 7.1 | 12 | 3 | Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit) |
ChEMBL | 520 | 6 | 1 | 8 | 6.9 | C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 | 10.1016/j.ejmech.2022.114642 | ||
| 5284329 | 3236 | None | 58 | Human | Functional | pEC50 | = | 7.1 | 7.1 | 12 | 3 | Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit) |
ChEMBL | 520 | 6 | 1 | 8 | 6.9 | C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 | 10.1016/j.ejmech.2022.114642 | ||
| CHEMBL1221984 | 3236 | None | 58 | Human | Functional | pEC50 | = | 7.1 | 7.1 | 12 | 3 | Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit)Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit) |
ChEMBL | 520 | 6 | 1 | 8 | 6.9 | C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2 | 10.1016/j.ejmech.2022.114642 | ||
| 172466555 | 196778 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | Negative allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as decrease in SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayNegative allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as decrease in SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay |
ChEMBL | 511 | 6 | 1 | 6 | 8.7 | c1ccc(-c2ccc(Nc3nc(Oc4cccc5ccccc45)nc4c3ncn4C3CCCCC3)cc2)cc1 | 10.1016/j.ejmech.2022.114642 | ||
| CHEMBL5432045 | 196778 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | - | 1 | Negative allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as decrease in SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayNegative allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as decrease in SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay |
ChEMBL | 511 | 6 | 1 | 6 | 8.7 | c1ccc(-c2ccc(Nc3nc(Oc4cccc5ccccc45)nc4c3ncn4C3CCCCC3)cc2)cc1 | 10.1016/j.ejmech.2022.114642 | ||
| 172444531 | 195503 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay |
ChEMBL | 534 | 6 | 2 | 8 | 7.0 | OC1CCN(c2ccc(Nc3nc(Oc4cccc5ccccc45)nc4c3ncn4C3CCCCC3)cc2)CC1 | 10.1016/j.ejmech.2022.114642 | ||
| CHEMBL5404963 | 195503 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Positive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assayPositive allosteric modulation of SCTR (unknown origin) overexpressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins by Lance cAMP assay |
ChEMBL | 534 | 6 | 2 | 8 | 7.0 | OC1CCN(c2ccc(Nc3nc(Oc4cccc5ccccc45)nc4c3ncn4C3CCCCC3)cc2)CC1 | 10.1016/j.ejmech.2022.114642 | ||
| 16158474 | 213407 | None | 12 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | NoneNone |
Drug Central | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C | None | ||||
| 16158474.0 | 213407 | None | 12 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | NoneNone |
Drug Central | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C | None | ||||
| CHEMBL3039582 | 213407 | None | 12 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | NoneNone |
Drug Central | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C | None | ||||
| DB09532 | 213407 | None | 12 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | NoneNone |
Drug Central | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C | None | ||||
| 1155 | 3572 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | 5 | 7 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 7612008 | ||||
| 16129665 | 3572 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | 5 | 7 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 7612008 | ||||
| 3643 | 3572 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | 5 | 7 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 7612008 | ||||
| CHEMBL1201488 | 3572 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | 5 | 7 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 7612008 | ||||
| DB00021 | 3572 | None | 0 | Human | Functional | pEC50 | = | 9.7 | 9.7 | 5 | 7 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 7612008 | ||||
| 1152 | 3995 | None | 15 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -3090 | 8 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 1646711 | ||||
| 16129679 | 3995 | None | 15 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -3090 | 8 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 1646711 | ||||
| 53395115 | 3995 | None | 15 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -3090 | 8 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 1646711 | ||||
| 91898389 | 3995 | None | 15 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -3090 | 8 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 1646711 | ||||
| CHEMBL1981592 | 3995 | None | 15 | Human | Functional | pIC50 | = | 5.4 | 5.4 | -3090 | 8 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 1646711 | ||||
| 1156 | 3575 | None | 0 | Rat | Functional | pIC50 | None | 5 | 5.0 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 1646711 | ||||
Showing 1 to 45 of 45 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| CHEMBL1256314 | 211124 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | Displacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysisDisplacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysis |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N1)C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2010.08.062 | ||||
| 16158474 | 213407 | None | 12 | Human | Binding | pKi | = | 8.5 | 8.5 | - | 1 | Displacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysisDisplacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysis |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2010.08.062 | ||||
| 16158474.0 | 213407 | None | 12 | Human | Binding | pKi | = | 8.5 | 8.5 | - | 1 | Displacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysisDisplacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysis |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2010.08.062 | ||||
| CHEMBL3039582 | 213407 | None | 12 | Human | Binding | pKi | = | 8.5 | 8.5 | - | 1 | Displacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysisDisplacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysis |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2010.08.062 | ||||
| DB09532 | 213407 | None | 12 | Human | Binding | pKi | = | 8.5 | 8.5 | - | 1 | Displacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysisDisplacement of [125I]-secretin-27 from secretin receptor expressed in CHO cells by gamma-spectrometer analysis |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C | 10.1016/j.bmcl.2010.08.062 | ||||
| 1152 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 4 | Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor |
Guide to Pharmacology | None | None | None | None | 9437714 | ||||
| 16129679 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 4 | Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor |
Guide to Pharmacology | None | None | None | None | 9437714 | ||||
| 53395115 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 4 | Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor |
Guide to Pharmacology | None | None | None | None | 9437714 | ||||
| 91898389 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 4 | Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor |
Guide to Pharmacology | None | None | None | None | 9437714 | ||||
| CHEMBL1981592 | 3995 | None | 15 | Rat | Binding | pIC50 | = | 6.2 | 6.2 | - | 4 | Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor |
Guide to Pharmacology | None | None | None | None | 9437714 | ||||
| 3293 | 468 | None | 0 | Rat | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor |
Guide to Pharmacology | None | None | None | None | 9437714 | ||||
| 1155 | 3572 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | 3162 | 2 | Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor |
Guide to Pharmacology | None | None | None | None | 9437714 | ||||
| 16129665 | 3572 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | 3162 | 2 | Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor |
Guide to Pharmacology | None | None | None | None | 9437714 | ||||
| 3643 | 3572 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | 3162 | 2 | Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor |
Guide to Pharmacology | None | None | None | None | 9437714 | ||||
| CHEMBL1201488 | 3572 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | 3162 | 2 | Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor |
Guide to Pharmacology | None | None | None | None | 9437714 | ||||
| DB00021 | 3572 | None | 0 | Rat | Binding | pIC50 | = | 9 | 9.0 | 3162 | 2 | Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor |
Guide to Pharmacology | None | None | None | None | 9437714 | ||||
| 3755 | 924 | None | 0 | Human | Binding | pKi | = | 5.3 | 5.3 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 1702423 | ||||
| 1155 | 3572 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | 3162 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 1646711 | ||||
| 16129665 | 3572 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | 3162 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 1646711 | ||||
| 3643 | 3572 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | 3162 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 1646711 | ||||
| CHEMBL1201488 | 3572 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | 3162 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 1646711 | ||||
| DB00021 | 3572 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | 3162 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 1646711 | ||||
| 2943 | 3573 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 10383421 | ||||
| 2943 | 3573 | None | 0 | Rat | Binding | pKi | = | 8.5 | 8.5 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 9694908 | ||||
Showing 1 to 24 of 24 entries