Initializing potency table...
Ligand source activities (1 row/activity)
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
2-chloroadenosine-5-triphosphate | 59 | None | 11 | Human | Binding | pKi | None | - | 5.60 | - | 4 | Unclassified | Guide to Pharmacology | 541.0 | 8 | 7 | 14 | -0.98 | Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O | https://pubmed.ncbi.nlm.nih.gov/9547364 | |
2-chloroadenosine-5-triphosphate | 59 | None | 11 | Human | Binding | EC50 | = | 770.00 | 6.11 | - | 4 | Accumulation of inositol phosphate in 1321N1 astrocytoma cells expressing human P2Y1 purinoceptor | ChEMBL | 541.0 | 8 | 7 | 14 | -0.98 | Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O | https://dx.doi.org/10.1021/jm010538v | |
2-chloroadenosine-5-triphosphate | 59 | None | 11 | Wild turkey | Binding | EC50 | = | 720.00 | 6.14 | - | 4 | Activation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranes | ChEMBL | 541.0 | 8 | 7 | 14 | -0.98 | Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O | https://dx.doi.org/10.1021/jm010538v | |
2MeSADP | 75 | None | 11 | Human | Binding | pKd | = | - | 7.30 | -10 | 5 | Unclassified | Guide to Pharmacology | 473.0 | 7 | 6 | 13 | -1.02 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | https://pubmed.ncbi.nlm.nih.gov/11502873 | |
2MeSADP | 75 | None | 11 | Human | Binding | EC50 | = | 6.40 | 8.19 | -10 | 5 | Accumulation of inositol phosphate in 1321N1 astrocytoma cells expressing human P2Y1 purinoceptor | ChEMBL | 473.0 | 7 | 6 | 13 | -1.02 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | https://dx.doi.org/10.1021/jm010538v | |
2MeSADP | 75 | None | 11 | Human | Binding | EC50 | = | 6.00 | 8.22 | -10 | 5 | Effective concentration to activate human Y273F mutant strain P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphate | ChEMBL | 473.0 | 7 | 6 | 13 | -1.02 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | https://dx.doi.org/10.1021/jm049914c | |
2MeSADP | 75 | None | 11 | Human | Binding | IC50 | = | 360.00 | 6.44 | -10 | 5 | Inhibition concentration required against human Y306F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand | ChEMBL | 473.0 | 7 | 6 | 13 | -1.02 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | https://dx.doi.org/10.1021/jm049914c | |
2MeSADP | 75 | None | 11 | Human | Binding | EC50 | = | 1.27 | 8.90 | -10 | 5 | Effective concentration required for the activation of wild-type P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate | ChEMBL | 473.0 | 7 | 6 | 13 | -1.02 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | https://dx.doi.org/10.1021/jm049914c | |
2MeSADP | 75 | None | 11 | Human | Binding | EC50 | = | 2.20 | 8.66 | -10 | 5 | Effective concentration required for the activation of wild-type P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate is determined in separate experiment | ChEMBL | 473.0 | 7 | 6 | 13 | -1.02 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | https://dx.doi.org/10.1021/jm049914c | |
2MeSADP | 75 | None | 11 | Human | Binding | EC50 | = | 18.20 | 7.74 | -10 | 5 | Effective concentration required for the activation of human F131A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate | ChEMBL | 473.0 | 7 | 6 | 13 | -1.02 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | https://dx.doi.org/10.1021/jm049914c | |
2MeSADP | 75 | None | 11 | Human | Binding | EC50 | = | 15.90 | 7.80 | -10 | 5 | Effective concentration required for the activation of human H132A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate | ChEMBL | 473.0 | 7 | 6 | 13 | -1.02 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | https://dx.doi.org/10.1021/jm049914c | |
2MeSADP | 75 | None | 11 | Human | Binding | EC50 | = | 12.60 | 7.90 | -10 | 5 | Effective concentration required for the activation of human Y136A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate | ChEMBL | 473.0 | 7 | 6 | 13 | -1.02 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | https://dx.doi.org/10.1021/jm049914c | |
2MeSADP | 75 | None | 11 | Human | Binding | EC50 | = | 15.90 | 7.80 | -10 | 5 | Effective concentration required for the activation of human T221A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate | ChEMBL | 473.0 | 7 | 6 | 13 | -1.02 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | https://dx.doi.org/10.1021/jm049914c | |
2MeSADP | 75 | None | 11 | Human | Binding | EC50 | = | 11.20 | 7.95 | -10 | 5 | Effective concentration required for the activation of human T222A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate | ChEMBL | 473.0 | 7 | 6 | 13 | -1.02 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | https://dx.doi.org/10.1021/jm049914c | |
2MeSADP | 75 | None | 11 | Human | Binding | EC50 | = | 20.70 | 7.68 | -10 | 5 | Effective concentration required for the activation of human F226A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate | ChEMBL | 473.0 | 7 | 6 | 13 | -1.02 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | https://dx.doi.org/10.1021/jm049914c | |
2MeSADP | 75 | None | 11 | Human | Binding | EC50 | = | 15.00 | 7.82 | -10 | 5 | Effective concentration to activate human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphate | ChEMBL | 473.0 | 7 | 6 | 13 | -1.02 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | https://dx.doi.org/10.1021/jm049914c | |
2MeSADP | 75 | None | 11 | Human | Binding | EC50 | = | 100.00 | 7.00 | -10 | 5 | Effective concentration required for the activation of human H277A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate | ChEMBL | 473.0 | 7 | 6 | 13 | -1.02 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | https://dx.doi.org/10.1021/jm049914c | |
2MeSADP | 75 | None | 11 | Human | Binding | EC50 | = | 1790.00 | 5.75 | -10 | 5 | Effective concentration required for the activation of human K280A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate | ChEMBL | 473.0 | 7 | 6 | 13 | -1.02 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | https://dx.doi.org/10.1021/jm049914c | |
2MeSADP | 75 | None | 11 | Human | Binding | EC50 | = | 455.00 | 6.34 | -10 | 5 | Effective concentration required for the activation of human Q307A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate | ChEMBL | 473.0 | 7 | 6 | 13 | -1.02 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | https://dx.doi.org/10.1021/jm049914c | |
2MeSADP | 75 | None | 11 | Human | Binding | EC50 | = | 418.00 | 6.38 | -10 | 5 | Effective concentration required for the activation of human R310K mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate | ChEMBL | 473.0 | 7 | 6 | 13 | -1.02 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | https://dx.doi.org/10.1021/jm049914c |
Showing 1 to 20 of 744 entries
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
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Common name |
GPCRdb ID |
Reference ligand |
Vendors | Species | Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI | |