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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

2-chloroadenosine-5-triphosphate	59	None	11	Human	Binding	pKi	None	-	5.60	-	4	Unclassified	Guide to Pharmacology	541.0	8	7	14	-0.98	Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O	https://pubmed.ncbi.nlm.nih.gov/9547364
2-chloroadenosine-5-triphosphate	59	None	11	Human	Binding	EC50	=	770.00	6.11	-	4	Accumulation of inositol phosphate in 1321N1 astrocytoma cells expressing human P2Y1 purinoceptor	ChEMBL	541.0	8	7	14	-0.98	Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O	https://dx.doi.org/10.1021/jm010538v
2-chloroadenosine-5-triphosphate	59	None	11	Wild turkey	Binding	EC50	=	720.00	6.14	-	4	Activation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranes	ChEMBL	541.0	8	7	14	-0.98	Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O	https://dx.doi.org/10.1021/jm010538v
2MeSADP	75	None	11	Human	Binding	pKd	=	-	7.30	-10	5	Unclassified	Guide to Pharmacology	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://pubmed.ncbi.nlm.nih.gov/11502873
2MeSADP	75	None	11	Human	Binding	EC50	=	6.40	8.19	-10	5	Accumulation of inositol phosphate in 1321N1 astrocytoma cells expressing human P2Y1 purinoceptor	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm010538v
2MeSADP	75	None	11	Human	Binding	EC50	=	6.00	8.22	-10	5	Effective concentration to activate human Y273F mutant strain P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm049914c
2MeSADP	75	None	11	Human	Binding	IC50	=	360.00	6.44	-10	5	Inhibition concentration required against human Y306F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm049914c
2MeSADP	75	None	11	Human	Binding	EC50	=	1.27	8.90	-10	5	Effective concentration required for the activation of wild-type P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm049914c
2MeSADP	75	None	11	Human	Binding	EC50	=	2.20	8.66	-10	5	Effective concentration required for the activation of wild-type P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate is determined in separate experiment	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm049914c
2MeSADP	75	None	11	Human	Binding	EC50	=	18.20	7.74	-10	5	Effective concentration required for the activation of human F131A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm049914c
2MeSADP	75	None	11	Human	Binding	EC50	=	15.90	7.80	-10	5	Effective concentration required for the activation of human H132A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm049914c
2MeSADP	75	None	11	Human	Binding	EC50	=	12.60	7.90	-10	5	Effective concentration required for the activation of human Y136A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm049914c
2MeSADP	75	None	11	Human	Binding	EC50	=	15.90	7.80	-10	5	Effective concentration required for the activation of human T221A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm049914c
2MeSADP	75	None	11	Human	Binding	EC50	=	11.20	7.95	-10	5	Effective concentration required for the activation of human T222A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm049914c
2MeSADP	75	None	11	Human	Binding	EC50	=	20.70	7.68	-10	5	Effective concentration required for the activation of human F226A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm049914c
2MeSADP	75	None	11	Human	Binding	EC50	=	15.00	7.82	-10	5	Effective concentration to activate human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm049914c
2MeSADP	75	None	11	Human	Binding	EC50	=	100.00	7.00	-10	5	Effective concentration required for the activation of human H277A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm049914c
2MeSADP	75	None	11	Human	Binding	EC50	=	1790.00	5.75	-10	5	Effective concentration required for the activation of human K280A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm049914c
2MeSADP	75	None	11	Human	Binding	EC50	=	455.00	6.34	-10	5	Effective concentration required for the activation of human Q307A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm049914c
2MeSADP	75	None	11	Human	Binding	EC50	=	418.00	6.38	-10	5	Effective concentration required for the activation of human R310K mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm049914c

Showing 1 to 20 of 744 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

2',3'-ddATP	47	None	0	Human	Functional	pIC50	None	-	8.00	-	1	Unclassified	Guide to Pharmacology	475.0	8	5	12	0.43	Nc1ncnc2c1ncn2[C@H]1CC[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O1	https://pubmed.ncbi.nlm.nih.gov/9154346
2,2'-pyridylisatogen tosylate	43	None	0	Human	Functional	pIC50	=	-	6.85	-	1	Unclassified	Guide to Pharmacology	396.1	2	1	5	3.15	Cc1ccc(S(=O)(=O)O)cc1.O=C1C(c2ccccn2)=[N+]([O-])c2ccccc21	https://pubmed.ncbi.nlm.nih.gov/15193995
2-chloroadenosine-5-triphosphate	59	None	11	Rat	Functional	EC50	=	3.60	8.44	199	4	Agonists activity was evaluated by release of [Ca2+] release of HEK 293 cells stably transfected with rat-brain P2Y purinoceptor 1 (P2Y1-R)	ChEMBL	541.0	8	7	14	-0.98	Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O	https://dx.doi.org/10.1021/jm020251d
2-Cl-ADP(α-BH₃)	60	None	0	Human	Functional	pEC50	=	-	8.15	-	1	Unclassified	Guide to Pharmacology	455.0	6	5	12	-0.92	[B-][P@@](=O)(OC[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)O	https://pubmed.ncbi.nlm.nih.gov/23751098
2MeSADP	75	None	11	Human	Functional	pIC50	=	-	6.20	-39	5	Unclassified	Guide to Pharmacology	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://pubmed.ncbi.nlm.nih.gov/9154346
2MeSADP	75	None	11	Human	Functional	pIC50	=	-	6.20	-39	5	Unclassified	Guide to Pharmacology	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://pubmed.ncbi.nlm.nih.gov/12391289
2MeSADP	75	None	11	Human	Functional	EC50	=	1.94	8.71	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(WT) human P2Y1 receptor.	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm970684u
2MeSADP	75	None	11	Human	Functional	EC50	=	19.20	7.72	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(F131A) human P2Y1 receptor.	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm970684u
2MeSADP	75	None	11	Human	Functional	EC50	=	17.70	7.75	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(H132A) human P2Y1 receptor.	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm970684u
2MeSADP	75	None	11	Human	Functional	EC50	=	12.30	7.91	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(Y136A) human P2Y1 receptor.	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm970684u
2MeSADP	75	None	11	Human	Functional	EC50	=	2.45	8.61	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(T221A) human P2Y1 receptor.	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm970684u
2MeSADP	75	None	11	Human	Functional	EC50	=	10.90	7.96	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(T222A) human P2Y1 receptor.	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm970684u
2MeSADP	75	None	11	Human	Functional	EC50	=	19.50	7.71	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(F226A) human P2Y1 receptor.	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm970684u
2MeSADP	75	None	11	Human	Functional	EC50	=	115.00	6.94	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(H277A) human P2Y1 receptor.	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm970684u
2MeSADP	75	None	11	Human	Functional	EC50	=	1520.00	5.82	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(K280A) human P2Y1 receptor.	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm970684u
2MeSADP	75	None	11	Human	Functional	EC50	=	323.00	6.49	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(Q307A) human P2Y1 receptor.	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm970684u
2MeSADP	75	None	11	Human	Functional	EC50	=	324.00	6.49	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(R310K) human P2Y1 receptor.	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm970684u
2MeSADP	75	None	11	Human	Functional	EC50	=	10.40	7.98	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(S314T) human P2Y1 receptor.	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm970684u
2MeSADP	75	None	11	Human	Functional	EC50	=	1.88	8.73	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(S317A) human P2Y1 receptor.	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm970684u
2MeSADP	75	None	11	Human	Functional	EC50	=	12.90	7.89	-39	5	Compound was measured for the antagonism of the activation of phospholipase C in mutant(WT) human P2Y1 receptor in presence of MRS2179 (P<0.005)	ChEMBL	473.0	7	6	13	-1.02	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm970684u

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Ligand source activities (1 row/activity)