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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

CHEMBL2216803	84371	None	0	Human	Binding	EC50	=	1.00	9.00	-	1	Allosteric activation of human FSH receptor	ChEMBL	653.2	10	2	6	5.75	COc1ccc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)N(c3ccc(C(N)=O)c(Cl)c3)C2=O)cc1OC	https://dx.doi.org/10.1016/j.bmc.2012.03.069
CHEMBL3263667	111198	None	0	Human	Binding	EC50	=	100.00	7.00	-	1	Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay	ChEMBL	570.3	10	2	7	4.18	Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2coc(C3CC3)n2)CC1	https://dx.doi.org/10.1021/acsmedchemlett.6b00082
CHEMBL3263691	111203	None	0	Human	Binding	EC50	=	100.00	7.00	-	1	Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay	ChEMBL	555.3	10	3	9	3.31	Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCc3nn[nH]n3)cc2NC(=O)c2coc(C3CC3)n2)CC1	https://dx.doi.org/10.1021/acsmedchemlett.6b00082
CHEMBL3809148	140518	None	0	Human	Binding	EC50	=	100.00	7.00	-	1	Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay	ChEMBL	557.3	9	2	5	4.46	Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2ccc(F)cc2)CC1	https://dx.doi.org/10.1021/acsmedchemlett.6b00082
CHEMBL4780505	182103	None	0	Human	Binding	IC50	=	8030.00	5.09	-	2	Antagonist activity at human FSHR expressed in CHO-K1 cells by PathHunter beta-arrestin assay	ChEMBL	565.2	4	2	6	5.09	COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)CCc3c([nH]c4ccccc34)[C@H](OCc3ccc(Br)cc3)C[C@@H]21	https://dx.doi.org/10.1016/j.bmc.2020.115546
CHEMBL5267037	193615	None	0	Human	Binding	IC50	=	1440.00	5.84	-	3	Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay	ChEMBL	439.2	4	1	3	5.65	CC(=O)N1c2ncc(NC(=O)CCc3cccc(Cl)c3)cc2C2(CCCCC2)C1(C)C	https://dx.doi.org/10.1016/j.bmc.2023.117258
CHEMBL5267043	193617	None	0	Human	Binding	IC50	=	156.00	6.81	-	3	Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay	ChEMBL	476.2	3	1	5	4.96	CC(=O)N1c2cnc(NC(=O)OCC3(C(F)(F)F)CC3)nc2C2(CCC(F)(F)CC2)C1(C)C	https://dx.doi.org/10.1016/j.bmc.2023.117258
CHEMBL5267166	193619	None	0	Human	Binding	IC50	=	6000.00	5.22	-	3	Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay	ChEMBL	440.2	3	1	3	6.44	CC(=O)N1c2ccc(NC(=O)OCc3cccc(Cl)c3)cc2C2(CCCCC2)C1(C)C	https://dx.doi.org/10.1016/j.bmc.2023.117258
CHEMBL5268512	193677	None	0	Human	Binding	IC50	=	5670.00	5.25	-	3	Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay	ChEMBL	387.3	2	1	4	5.02	CC(=O)N1c2ncc(NC(=O)OCC(C)(C)C)cc2C2(CCCCC2)C1(C)C	https://dx.doi.org/10.1016/j.bmc.2023.117258
CHEMBL5268829	193688	None	0	Human	Binding	IC50	=	10000.00	5.00	-	3	Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay	ChEMBL	410.2	1	1	5	4.42	CC(=O)N1c2cnc(NC(=O)OC(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C	https://dx.doi.org/10.1016/j.bmc.2023.117258
CHEMBL5270266	193735	None	0	Human	Binding	IC50	=	214.00	6.67	-	3	Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay	ChEMBL	408.2	3	1	5	4.57	CC(=O)N1c2cnc(NC(=O)OCc3ccccc3)nc2C2(CCCCC2)C1(C)C	https://dx.doi.org/10.1016/j.bmc.2023.117258
CHEMBL5270771	193758	None	0	Human	Binding	IC50	=	1750.00	5.76	-	3	Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay	ChEMBL	478.2	3	1	5	5.47	CC(=O)N1c2cnc(NC(=O)OCc3cccc(Cl)c3)nc2C2(CCC(F)(F)CC2)C1(C)C	https://dx.doi.org/10.1016/j.bmc.2023.117258
CHEMBL5271120	193778	None	0	Human	Binding	IC50	=	2550.00	5.59	-	3	Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay	ChEMBL	386.3	2	1	3	5.63	CC(=O)N1c2ccc(NC(=O)OCC(C)(C)C)cc2C2(CCCCC2)C1(C)C	https://dx.doi.org/10.1016/j.bmc.2023.117258
CHEMBL5273361	193867	None	0	Human	Binding	IC50	=	322.00	6.49	-	3	Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay	ChEMBL	424.2	4	1	2	5.87	CC(=O)N1c2ccc(NC(=O)CCc3cccc(Cl)c3)cc2C2(CCCCC2)C1C	https://dx.doi.org/10.1016/j.bmc.2023.117258
CHEMBL5275140	193949	None	0	Human	Binding	IC50	=	606.00	6.22	-	3	Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay	ChEMBL	438.2	3	1	5	5.05	CC(=O)N1c2cnc(NC(=O)OC(C)(C)C(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C	https://dx.doi.org/10.1016/j.bmc.2023.117258
CHEMBL5275472	193965	None	0	Human	Binding	IC50	=	912.00	6.04	-	3	Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay	ChEMBL	424.2	2	1	5	4.66	CC(=O)N1c2cnc(NC(=O)OCC(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C	https://dx.doi.org/10.1016/j.bmc.2023.117258
CHEMBL5275619	193975	None	0	Human	Binding	IC50	=	432.00	6.37	-	3	Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay	ChEMBL	388.2	2	1	5	4.42	CC(=O)N1c2cnc(NC(=O)OCC(C)(C)C)nc2C2(CCCCC2)C1(C)C	https://dx.doi.org/10.1016/j.bmc.2023.117258
CHEMBL5279687	194145	None	0	Human	Binding	IC50	=	466.00	6.33	-	3	Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay	ChEMBL	440.2	4	1	4	5.05	CC(=O)N1c2cnc(NC(=O)CCc3cccc(Cl)c3)nc2C2(CCCCC2)C1(C)C	https://dx.doi.org/10.1016/j.bmc.2023.117258
CHEMBL5280508	194181	None	0	Human	Binding	IC50	=	458.00	6.34	-	3	Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay	ChEMBL	438.2	4	1	2	6.26	CC(=O)N1c2ccc(NC(=O)CCc3cccc(Cl)c3)cc2C2(CCCCC2)C1(C)C	https://dx.doi.org/10.1016/j.bmc.2023.117258
CHEMBL5281228	194216	None	0	Human	Binding	IC50	=	17.00	7.77	-	2	Allosteric antagonist activity at human FSHR expressed in CHO cells assessed as inhibition of FSH-induced activity incubated for 4 hrs by CRE-luciferase assay	ChEMBL	480.2	5	1	2	6.34	CC(=O)N1CCC(C)(c2ccccc2)c2cc(NC(=O)CCc3cccc(C(F)(F)F)c3)ccc21	https://dx.doi.org/10.1016/j.bmc.2023.117258

Showing 1 to 20 of 30 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)