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Ligand source activities (1 row/activity)

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Potency

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

CHEMBL3315335	113371	None	0	Human	Binding	IC50	=	43.90	7.36	-	2	Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting	ChEMBL	834.5	25	11	10	-1.56	CC(C)C[C@H](NC(=O)CCC1CCCCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2017.12.035
CHEMBL3315349	213839	None	2	Human	Binding	EC50	=	6100.00	5.21	-	2	Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.bmc.2014.08.038
CHEMBL3343012	115118	None	2	Human	Binding	EC50	=	37300.00	4.43	-	1	Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay	ChEMBL	256.1	1	1	3	3.31	O=c1c(O)c(-c2ccccc2F)oc2ccccc12	https://dx.doi.org/10.1016/j.bmc.2014.08.038
CHEMBL3343013	115119	None	0	Human	Binding	EC50	=	31100.00	4.51	-	1	Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay	ChEMBL	290.0	1	1	3	3.96	O=c1c(O)c(-c2cccc(Cl)c2F)oc2ccccc12	https://dx.doi.org/10.1016/j.bmc.2014.08.038
CHEMBL3343014	115120	None	0	Human	Binding	EC50	=	73000.00	4.14	-	1	Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay	ChEMBL	334.0	1	1	3	4.07	O=c1c(O)c(-c2ccc(Br)cc2F)oc2ccccc12	https://dx.doi.org/10.1016/j.bmc.2014.08.038
CHEMBL3343023	115121	None	0	Human	Binding	EC50	=	47000.00	4.33	-	1	Agonist activity at human NMU2R transfected in HEK293 cells after 7 hrs by luciferase reporter gene assay	ChEMBL	378.0	4	1	4	3.73	O=c1c(OCCO)c(-c2cc(Br)ccc2F)oc2ccccc12	https://dx.doi.org/10.1016/j.bmc.2014.08.038
CHEMBL3356083	214020	None	12	Human	Binding	IC50	=	1.70	8.77	-	4	Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2017.12.035
CHEMBL3356083	214020	None	12	Human	Binding	IC50	=	1.70	8.77	-	4	Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cells after 3 hrs by topcount micro scintillation counting method	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1021/acsmedchemlett.8b00105
CHEMBL4159176	162077	None	0	Human	Binding	IC50	=	428.90	6.37	-	2	Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting	ChEMBL	1140.6	33	16	14	-2.37	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N(CCc1ccc(O)cc1)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2017.12.035
CHEMBL4159554	162102	None	0	Human	Binding	IC50	=	18.80	7.73	-	2	Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cells after 3 hrs by topcount micro scintillation counting method	ChEMBL	1242.7	35	16	13	-0.41	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)NCc1ccccc1)C(N)=O	https://dx.doi.org/10.1021/acsmedchemlett.8b00105
CHEMBL4160825	162177	None	0	Human	Binding	IC50	=	370.50	6.43	-	2	Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting	ChEMBL	1160.6	32	16	13	-1.27	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2017.12.035
CHEMBL4161037	162188	None	0	Human	Binding	IC50	=	1365.00	5.87	-	2	Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting	ChEMBL	1152.6	33	16	13	-2.24	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2017.12.035
CHEMBL4161095	162190	None	0	Human	Binding	IC50	=	1961.00	5.71	-	2	Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting	ChEMBL	1126.6	32	16	14	-2.41	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O)Cc1ccc(O)cc1	https://dx.doi.org/10.1016/j.ejmech.2017.12.035
CHEMBL4161479	162214	None	0	Human	Binding	IC50	=	116.50	6.93	-	2	Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cells after 3 hrs by topcount micro scintillation counting method	ChEMBL	1166.6	34	16	13	-1.85	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)CC(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1021/acsmedchemlett.8b00105
CHEMBL4161501	162217	None	0	Human	Binding	IC50	=	253.40	6.60	-	2	Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting	ChEMBL	1156.7	30	15	13	-1.81	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O)C[C@@H]2CCCC[C@@H]21	https://dx.doi.org/10.1016/j.ejmech.2017.12.035
CHEMBL4161902	162243	None	0	Human	Binding	IC50	=	5.60	8.25	-	2	Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting	ChEMBL	1186.6	33	15	12	-0.79	CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2017.12.035
CHEMBL4162351	162265	None	0	Human	Binding	IC50	=	40.40	7.39	-	2	Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cells after 3 hrs by topcount micro scintillation counting method	ChEMBL	1178.6	31	16	13	-1.93	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NC1(C(=O)N[C@@H](CCCNC(=N)N)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O)CCc2ccccc2C1	https://dx.doi.org/10.1021/acsmedchemlett.8b00105
CHEMBL4162728	162297	None	0	Human	Binding	IC50	=	301.90	6.52	-	2	Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cells after 3 hrs by topcount micro scintillation counting method	ChEMBL	1214.6	30	15	13	-0.86	CC(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1021/acsmedchemlett.8b00105
CHEMBL4162868	162307	None	0	Human	Binding	IC50	=	206.90	6.68	-	2	Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting	ChEMBL	1182.6	34	16	14	-2.19	CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N(CCc1ccc(O)cc1)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2017.12.035
CHEMBL4164026	162372	None	0	Human	Binding	IC50	=	9.90	8.00	-	2	Displacement of [3H]-NMU-8 from human NMUR2 expressed in HEK293 cell membranes after 3 hrs by microscintillation counting	ChEMBL	1144.6	32	15	12	-0.97	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2017.12.035

Showing 1 to 20 of 63 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

CHEMBL3315278	113368	None	0	Human	Functional	EC50	=	8.40	8.08	1	2	Partial agonist activity at human NMUR2 expressed in CHO cells by calcium mobilization assay	ChEMBL	932.5	28	13	10	-1.79	CC(C)C[C@H](NC(=O)CCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1021/jm500599s
CHEMBL3315335	113371	None	0	Human	Functional	EC50	=	6.40	8.19	416	2	Agonist activity at human NMUR2 expressed in CHO cells by calcium mobilization assay	ChEMBL	834.5	25	11	10	-1.56	CC(C)C[C@H](NC(=O)CCC1CCCCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1021/jm500599s
CHEMBL3315335	113371	None	0	Human	Functional	EC50	=	6.40	8.19	416	2	Agonist activity at human NMUR2 expressed in CHO cells by Fluo-4-AM dye based calcium mobilization assay	ChEMBL	834.5	25	11	10	-1.56	CC(C)C[C@H](NC(=O)CCC1CCCCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.bmc.2020.115454
CHEMBL3315335	113371	None	0	Human	Functional	EC50	=	3.80	8.42	416	2	Agonist activity at human NMUR2 expressed in HEK293 cells assessed as induction of IP3 levels using myo-[2-3H(N)]-inositol after 60 mins by SPA-based topcount assay	ChEMBL	834.5	25	11	10	-1.56	CC(C)C[C@H](NC(=O)CCC1CCCCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2017.12.035
CHEMBL3315349	213839	None	2	Human	Functional	EC50	=	2.50	8.60	-25	2	Agonist activity at human NMUR2 expressed in CHO cells by calcium mobilization assay	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1021/jm500599s
CHEMBL3315349	213839	None	2	Human	Functional	EC50	=	0.79	9.10	-25	2	Agonist activity at recombinant human NMU2 expressed in HEK293 cells assessed as change in intracellular calcium flux by fluorescence assay	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2015.07.020
CHEMBL3315349	213839	None	2	Human	Functional	EC50	=	0.92	9.04	-25	2	Agonist activity at human NMUR2 expressed in CHO cells assessed as intracellular calcium flux at by Fluo-4 AM dye based fluorometric imaging method	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1021/ml500494j
CHEMBL3356082	214019	None	0	Human	Functional	EC50	=	391.00	6.41	-2	4	Agonist activity at human NMUR2 expressed in HEK293 cells assessed as induction of IP3 levels using myo-[2-3H(N)]-inositol after 60 mins by SPA-based topcount assay	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2017.12.035
CHEMBL3356082	214019	None	0	Mouse	Functional	EC50	=	156.00	6.81	2	4	Agonist activity at mouse NMUR2 expressed in HEK293 cells by calcium mobilization assay	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1021/jm500599s
CHEMBL3356083	214020	None	12	Human	Functional	EC50	=	0.40	9.40	-2	4	Agonist activity at human NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1021/acs.jmedchem.7b00330
CHEMBL3356083	214020	None	12	Human	Functional	EC50	=	0.43	9.37	-2	4	Agonist activity at human NMUR2 expressed in CHO cells assessed as increase in intracellular calcium influx after 180 secs by Fluo 4-AM dye based FLIPR assay	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.bmcl.2017.09.019
CHEMBL3356083	214020	None	12	Human	Functional	EC50	=	30.80	7.51	-2	4	Agonist activity at human NMUR2 expressed in HEK293 cells assessed as induction of IP3 levels using myo-[2-3H(N)]-inositol after 60 mins by SPA-based topcount assay	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2017.12.035
CHEMBL3356083	214020	None	12	Human	Functional	EC50	=	30.80	7.51	-2	4	Agonist activity at human NMUR2 expressed in HEK293 cells assessed as IP3 accumulation after 60 mins in presence of myo-[2-3H(N)]inositol by scintillation proximity assay	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1021/acsmedchemlett.8b00105
CHEMBL3356083	214020	None	12	Mouse	Functional	EC50	=	3.00	8.52	2	4	Agonist activity at mouse NMUR2 expressed in HEK293 cells by calcium mobilization assay	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1021/jm500599s
CHEMBL3356083	214020	None	12	Mouse	Functional	EC50	=	0.18	9.74	2	4	Agonist activity at mouse NMUR2 expressed in CHO cells assessed as induction of Ca2+ flux measured for 180 secs by Fluo 4-AM dye-based FLIPR assay	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1021/acs.jmedchem.7b00330
CHEMBL3356083	214020	None	12	Mouse	Functional	EC50	=	0.43	9.37	2	4	Agonist activity at mouse NMUR2 expressed in CHO cells assessed as increase in intracellular calcium influx after 180 secs by Fluo 4-AM dye based FLIPR assay	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.bmcl.2017.09.019
CHEMBL3758417	137744	None	0	Human	Functional	EC50	=	724.44	6.14	1	2	Agonist activity at recombinant human NMU2 expressed in HEK293 cells assessed as change in intracellular calcium flux by fluorescence assay	ChEMBL	1433.8	46	20	17	-1.50	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCCNC(=O)[C@@H](N)CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCCCC(=O)N[C@@H](CS)C(N)=O)C[C@@H]2CCCC[C@@H]21	https://dx.doi.org/10.1016/j.ejmech.2015.07.020
CHEMBL3758577	214685	None	0	Human	Functional	EC50	=	0.21	9.67	2	2	Agonist activity at recombinant human NMU2 expressed in HEK293 cells assessed as change in intracellular calcium flux by fluorescence assay	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C(C)(C)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2015.07.020
CHEMBL3758687	214686	None	0	Human	Functional	EC50	=	56.23	7.25	1	2	Agonist activity at recombinant human NMU2 expressed in HEK293 cells assessed as change in intracellular calcium flux by fluorescence assay	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C(C)(C)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)NC(C)(C)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2015.07.020
CHEMBL3758845	137793	None	0	Human	Functional	EC50	=	10000.00	5.00	1	2	Agonist activity at recombinant human NMU2 expressed in HEK293 cells assessed as change in intracellular calcium flux by fluorescence assay	ChEMBL	1595.1	65	16	14	7.58	CCCCCCCCCCCCCCCCNC(=O)CN(CCCCCCCCCCCCCCCC)CC(=O)NC(C)(C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O	https://dx.doi.org/10.1016/j.ejmech.2015.07.020

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