Ligand source activities (1 row/activity)
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 6120 | 8522 | 0 | None | -15 | 2 | Rat | 7.5 | pEC50 | = | 7.5 | Functional | Guide to Pharmacology | None | None | None | None | 10601261 | ||||
| 16133243 | 8497 | 0 | None | -1 | 5 | Rat | 9.8 | pEC50 | = | 9.8 | Functional | Guide to Pharmacology | None | None | None | None | 10601261 | ||||
| 3593 | 8497 | 0 | None | -1 | 5 | Rat | 9.8 | pEC50 | = | 9.8 | Functional | Guide to Pharmacology | None | None | None | None | 10601261 | ||||
| 101927062 | 8495 | 22 | None | 1 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 101927062 | 8495 | 22 | None | 1 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 155817445 | 8495 | 22 | None | 1 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 155817445 | 8495 | 22 | None | 1 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 16133823 | 8495 | 22 | None | 1 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 16133823 | 8495 | 22 | None | 1 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 3592 | 8495 | 22 | None | 1 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 3592 | 8495 | 22 | None | 1 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 44584852 | 8495 | 22 | None | 1 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 44584852 | 8495 | 22 | None | 1 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 6090 | 8495 | 22 | None | 1 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 6090 | 8495 | 22 | None | 1 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 91898917 | 8495 | 22 | None | 1 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 91898917 | 8495 | 22 | None | 1 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| CHEMBL506553 | 8495 | 22 | None | 1 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| CHEMBL506553 | 8495 | 22 | None | 1 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 155817484 | 8496 | 0 | None | 2 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 155817484 | 8496 | 0 | None | 2 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 6117 | 8496 | 0 | None | 2 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 6117 | 8496 | 0 | None | 2 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 6129 | 8496 | 0 | None | 2 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 6129 | 8496 | 0 | None | 2 | 5 | Rat | 10.2 | pIC50 | = | 10.2 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 3898 | 9224 | 0 | None | -3 | 4 | Human | 10.4 | pIC50 | = | 10.4 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 3898 | 9224 | 0 | None | 3 | 4 | Rat | 11.0 | pIC50 | = | 11 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 3898 | 9224 | 0 | None | 3 | 4 | Rat | 11.0 | pIC50 | = | 11 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 20549618 | 6837 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | Guide to Pharmacology | 182 | 0 | 0 | 4 | -0.7 | O=S1(=O)CCS(=O)(=O)C=C1 | 10896115 | ||
| 3486 | 6837 | 0 | None | - | 1 | Human | 5.6 | pIC50 | = | 5.6 | Functional | Guide to Pharmacology | 182 | 0 | 0 | 4 | -0.7 | O=S1(=O)CCS(=O)(=O)C=C1 | 10896115 | ||
| 155817474 | 8509 | 0 | None | -489 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | Guide to Pharmacology | None | None | None | None | 11481429 | ||||
| 5357 | 8509 | 0 | None | -489 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | Guide to Pharmacology | None | None | None | None | 11481429 | ||||
| 6124 | 8221 | 1 | None | 158 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | Guide to Pharmacology | 286 | 1 | 0 | 4 | 1.5 | Cc1ccc(cc1)C1=CS(=O)(=O)CCCS1(=O)=O | 10896115 | ||
| 9947811 | 8221 | 1 | None | 158 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | Guide to Pharmacology | 286 | 1 | 0 | 4 | 1.5 | Cc1ccc(cc1)C1=CS(=O)(=O)CCCS1(=O)=O | 10896115 | ||
| CHEMBL3906195 | 8221 | 1 | None | 158 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | Guide to Pharmacology | 286 | 1 | 0 | 4 | 1.5 | Cc1ccc(cc1)C1=CS(=O)(=O)CCCS1(=O)=O | 10896115 | ||
| 155817485 | 8538 | 0 | None | -1 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | Guide to Pharmacology | None | None | None | None | 15944009 | ||||
| 6121 | 8538 | 0 | None | -1 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | Guide to Pharmacology | None | None | None | None | 15944009 | ||||
| 3594 | 8523 | 0 | None | -7 | 3 | Human | 7.1 | pIC50 | = | 7.1 | Functional | Guide to Pharmacology | None | None | None | None | 15944009 | ||||
| 3596 | 8524 | 0 | None | -29 | 2 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | Guide to Pharmacology | None | None | None | None | 20880399 | ||||
| 134813891 | 8539 | 0 | None | -2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | None | None | None | None | 15944009 | ||||
| 6122 | 8539 | 0 | None | -2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | None | None | None | None | 15944009 | ||||
| 155817487 | 8510 | 0 | None | -9 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 6130 | 8510 | 0 | None | -9 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 155817465 | 8511 | 0 | None | -3 | 3 | Human | 8.0 | pIC50 | = | 8 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 3876 | 8511 | 0 | None | -3 | 3 | Human | 8.0 | pIC50 | = | 8 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 155817465 | 8511 | 0 | None | -2 | 3 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 155817465 | 8511 | 0 | None | -2 | 3 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 3876 | 8511 | 0 | None | -2 | 3 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 3876 | 8511 | 0 | None | -2 | 3 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 155817463 | 7564 | 0 | None | -1 | 4 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 155817463 | 7564 | 0 | None | -1 | 4 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 3861 | 7564 | 0 | None | -1 | 4 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 3861 | 7564 | 0 | None | -1 | 4 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 6120 | 8522 | 0 | None | -15 | 2 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | None | None | None | None | 10601261 | ||||
| 155817463 | 7564 | 0 | None | 1 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 155817463 | 7564 | 0 | None | 1 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 3861 | 7564 | 0 | None | 1 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 3861 | 7564 | 0 | None | 1 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 16131409 | 8504 | 0 | None | -1 | 3 | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 6086 | 8504 | 0 | None | -1 | 3 | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 3896 | 9221 | 0 | None | -1 | 4 | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 3896 | 9221 | 0 | None | -1 | 4 | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 155817473 | 8501 | 0 | None | 1 | 2 | Human | 9.0 | pIC50 | = | 9.0 | Functional | Guide to Pharmacology | None | None | None | None | 11481429 | ||||
| 5356 | 8501 | 0 | None | 1 | 2 | Human | 9.0 | pIC50 | = | 9.0 | Functional | Guide to Pharmacology | None | None | None | None | 11481429 | ||||
| 6084 | 8501 | 0 | None | 1 | 2 | Human | 9.0 | pIC50 | = | 9.0 | Functional | Guide to Pharmacology | None | None | None | None | 11481429 | ||||
| 3896 | 9221 | 0 | None | 1 | 4 | Rat | 9.0 | pIC50 | = | 9 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 3896 | 9221 | 0 | None | 1 | 4 | Rat | 9.0 | pIC50 | = | 9 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 3899 | 9225 | 0 | None | -1 | 4 | Rat | 9.1 | pIC50 | = | 9.1 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 3899 | 9225 | 0 | None | -1 | 4 | Rat | 9.1 | pIC50 | = | 9.1 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 16132180 | 8505 | 21 | None | -2 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 16132180 | 8505 | 21 | None | -2 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 16133822 | 8505 | 21 | None | -2 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 16133822 | 8505 | 21 | None | -2 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 6087 | 8505 | 21 | None | -2 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 6087 | 8505 | 21 | None | -2 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| CHEMBL499980 | 8505 | 21 | None | -2 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| CHEMBL499980 | 8505 | 21 | None | -2 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 3899 | 9225 | 0 | None | 1 | 4 | Human | 9.3 | pIC50 | = | 9.3 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 6082 | 10255 | 0 | None | 4 | 2 | Human | 9.4 | pIC50 | = | 9.4 | Functional | Guide to Pharmacology | None | None | None | None | 11491429 | ||||
| 16133243 | 8497 | 0 | None | -1 | 5 | Rat | 9.4 | pIC50 | = | 9.4 | Functional | Guide to Pharmacology | None | None | None | None | 10601261 | ||||
| 16133243 | 8497 | 0 | None | -1 | 5 | Rat | 9.4 | pIC50 | = | 9.4 | Functional | Guide to Pharmacology | None | None | None | None | 20880399 | ||||
| 3593 | 8497 | 0 | None | -1 | 5 | Rat | 9.4 | pIC50 | = | 9.4 | Functional | Guide to Pharmacology | None | None | None | None | 10601261 | ||||
| 3593 | 8497 | 0 | None | -1 | 5 | Rat | 9.4 | pIC50 | = | 9.4 | Functional | Guide to Pharmacology | None | None | None | None | 20880399 | ||||
| 6088 | 8506 | 0 | None | -2 | 2 | Human | 9.5 | pIC50 | = | 9.5 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 90469849 | 8506 | 0 | None | -2 | 2 | Human | 9.5 | pIC50 | = | 9.5 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 16132180 | 8505 | 21 | None | 2 | 4 | Rat | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 16132180 | 8505 | 21 | None | 2 | 4 | Rat | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 16133822 | 8505 | 21 | None | 2 | 4 | Rat | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 16133822 | 8505 | 21 | None | 2 | 4 | Rat | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 6087 | 8505 | 21 | None | 2 | 4 | Rat | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 6087 | 8505 | 21 | None | 2 | 4 | Rat | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| CHEMBL499980 | 8505 | 21 | None | 2 | 4 | Rat | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| CHEMBL499980 | 8505 | 21 | None | 2 | 4 | Rat | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 101927062 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 11481429 | ||||
| 101927062 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 101927062 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 155817445 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 11481429 | ||||
| 155817445 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 155817445 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 16133823 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 11481429 | ||||
| 16133823 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 16133823 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 3592 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 11481429 | ||||
| 3592 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 3592 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 44584852 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 11481429 | ||||
| 44584852 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 44584852 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 6090 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 11481429 | ||||
| 6090 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 6090 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 91898917 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 11481429 | ||||
| 91898917 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 91898917 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| CHEMBL506553 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 11481429 | ||||
| CHEMBL506553 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| CHEMBL506553 | 8495 | 22 | None | -1 | 5 | Human | 9.7 | pIC50 | = | 9.7 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 155817484 | 8496 | 0 | None | -2 | 5 | Human | 9.8 | pIC50 | = | 9.8 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 155817484 | 8496 | 0 | None | -2 | 5 | Human | 9.8 | pIC50 | = | 9.8 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 6117 | 8496 | 0 | None | -2 | 5 | Human | 9.8 | pIC50 | = | 9.8 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 6117 | 8496 | 0 | None | -2 | 5 | Human | 9.8 | pIC50 | = | 9.8 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 6129 | 8496 | 0 | None | -2 | 5 | Human | 9.8 | pIC50 | = | 9.8 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 6129 | 8496 | 0 | None | -2 | 5 | Human | 9.8 | pIC50 | = | 9.8 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 6088 | 8506 | 0 | None | 2 | 2 | Rat | 9.8 | pIC50 | = | 9.8 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 90469849 | 8506 | 0 | None | 2 | 2 | Rat | 9.8 | pIC50 | = | 9.8 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 16133243 | 8497 | 0 | None | 1 | 5 | Human | 9.9 | pIC50 | = | 9.9 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 3593 | 8497 | 0 | None | 1 | 5 | Human | 9.9 | pIC50 | = | 9.9 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 131863305 | 7115 | 0 | None | -1 | 3 | Rat | 6.0 | pIC50 | > | 6 | Functional | Guide to Pharmacology | None | None | None | None | 20880399 | ||||
| 155817486 | 7115 | 0 | None | -1 | 3 | Rat | 6.0 | pIC50 | > | 6 | Functional | Guide to Pharmacology | None | None | None | None | 20880399 | ||||
| 6123 | 7115 | 0 | None | -1 | 3 | Rat | 6.0 | pIC50 | > | 6 | Functional | Guide to Pharmacology | None | None | None | None | 20880399 | ||||
| 155817480 | 8512 | 0 | None | 1 | 3 | Human | 6.0 | pIC50 | > | 6 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 6091 | 8512 | 0 | None | 1 | 3 | Human | 6.0 | pIC50 | > | 6 | Functional | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 155817481 | 8513 | 0 | None | 1 | 3 | Human | 6.0 | pIC50 | > | 6 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 155817481 | 8513 | 0 | None | -1 | 3 | Rat | 6.0 | pIC50 | > | 6 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 155817481 | 8513 | 0 | None | -1 | 3 | Rat | 6.0 | pIC50 | > | 6 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 6092 | 8513 | 0 | None | 1 | 3 | Human | 6.0 | pIC50 | > | 6 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| 6092 | 8513 | 0 | None | -1 | 3 | Rat | 6.0 | pIC50 | > | 6 | Functional | Guide to Pharmacology | None | None | None | None | 9108306 | ||||
| 6092 | 8513 | 0 | None | -1 | 3 | Rat | 6.0 | pIC50 | > | 6 | Functional | Guide to Pharmacology | None | None | None | None | 9168941 | ||||
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 101927062 | 8495 | 22 | None | -10 | 6 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| 155817445 | 8495 | 22 | None | -10 | 6 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| 16133823 | 8495 | 22 | None | -10 | 6 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| 3592 | 8495 | 22 | None | -10 | 6 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| 44584852 | 8495 | 22 | None | -10 | 6 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| 6090 | 8495 | 22 | None | -10 | 6 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| 91898917 | 8495 | 22 | None | -10 | 6 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| CHEMBL506553 | 8495 | 22 | None | -10 | 6 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
| CHEMBL501079 | 220909 | 13 | None | 11 | 2 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1016/j.bmc.2013.03.016 | ||||
| CHEMBL501079 | 220909 | 13 | None | 11 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1016/j.ejmech.2013.01.044 | ||||
| CHEMBL501079 | 220909 | 13 | None | 11 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1021/jm8007618 | ||||
| CHEMBL473840 | 220808 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](C)[C@@H](C)O)NC(=O)[C@H](C(C)C)NC1=O | 10.1016/j.bmcl.2008.10.104 | ||||
| 134142691 | 152474 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 344 | 3 | 0 | 6 | 1.4 | CCOC(=O)c1cccc(C2=CS(=O)(=O)CCCS2(=O)=O)c1 | nan | ||
| CHEMBL3916206 | 152474 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 344 | 3 | 0 | 6 | 1.4 | CCOC(=O)c1cccc(C2=CS(=O)(=O)CCCS2(=O)=O)c1 | nan | ||
| 101061658 | 155361 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 302 | 2 | 0 | 5 | 1.2 | COc1ccccc1C1=CS(=O)(=O)CCCS1(=O)=O | nan | ||
| CHEMBL3939021 | 155361 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 302 | 2 | 0 | 5 | 1.2 | COc1ccccc1C1=CS(=O)(=O)CCCS1(=O)=O | nan | ||
| 12043584 | 157576 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 336 | 1 | 0 | 4 | 1.6 | O=S1(=O)C=C(c2ccc(Br)cc2)S(=O)(=O)CC1 | nan | ||
| CHEMBL3956728 | 157576 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 336 | 1 | 0 | 4 | 1.6 | O=S1(=O)C=C(c2ccc(Br)cc2)S(=O)(=O)CC1 | nan | ||
| 134155181 | 158169 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 477 | 9 | 1 | 6 | 2.9 | CCCCOc1ccccc1C(=O)NC(Cc1ccccc1)C1=CS(=O)(=O)CCS1(=O)=O | nan | ||
| CHEMBL3961540 | 158169 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 477 | 9 | 1 | 6 | 2.9 | CCCCOc1ccccc1C(=O)NC(Cc1ccccc1)C1=CS(=O)(=O)CCS1(=O)=O | nan | ||
| 9861375 | 160036 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 306 | 1 | 0 | 4 | 1.9 | O=S1(=O)C=C(c2cccc(Cl)c2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3977579 | 160036 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 306 | 1 | 0 | 4 | 1.9 | O=S1(=O)C=C(c2cccc(Cl)c2)S(=O)(=O)CCC1 | nan | ||
| 90721869 | 157127 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 357 | 4 | 1 | 5 | 1.4 | CCCNC(=O)c1ccc(C2=CS(=O)(=O)CCCS2(=O)=O)cc1 | nan | ||
| CHEMBL3953131 | 157127 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 357 | 4 | 1 | 5 | 1.4 | CCCNC(=O)c1ccc(C2=CS(=O)(=O)CCCS2(=O)=O)cc1 | nan | ||
| 134142161 | 152361 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 419 | 5 | 1 | 5 | 2.2 | O=C(NCCc1ccccc1)c1ccc(C2=CS(=O)(=O)CCCS2(=O)=O)cc1 | nan | ||
| CHEMBL3915361 | 152361 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 419 | 5 | 1 | 5 | 2.2 | O=C(NCCc1ccccc1)c1ccc(C2=CS(=O)(=O)CCCS2(=O)=O)cc1 | nan | ||
| CHEMBL474038 | 220810 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](C)[C@@H](C)O)NC(=O)[C@H](C(C)C)NC1=O | 10.1016/j.bmcl.2008.10.104 | ||||
| CHEMBL474037 | 220809 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](C)[C@@H](C)O)NC1=O | 10.1016/j.bmcl.2008.10.104 | ||||
| 91480105 | 160312 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 354 | 2 | 0 | 4 | 3.3 | O=S1(=O)C=C(c2ccc(C3CCCCC3)cc2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3980007 | 160312 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 354 | 2 | 0 | 4 | 3.3 | O=S1(=O)C=C(c2ccc(C3CCCCC3)cc2)S(=O)(=O)CCC1 | nan | ||
| 57399456 | 75574 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 430 | 6 | 1 | 7 | 4.2 | COc1ccc(Nc2cc(N3CCN(c4ccccc4)CC3)nc(N3CCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1921992 | 75574 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 430 | 6 | 1 | 7 | 4.2 | COc1ccc(Nc2cc(N3CCN(c4ccccc4)CC3)nc(N3CCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| 57394238 | 75586 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 529 | 5 | 1 | 7 | 5.8 | Cc1c(F)cccc1Nc1cc(N2CCCCC2)nc(N2CCCN(c3ncccc3C(F)(F)F)CC2)n1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1922003 | 75586 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 529 | 5 | 1 | 7 | 5.8 | Cc1c(F)cccc1Nc1cc(N2CCCCC2)nc(N2CCCN(c3ncccc3C(F)(F)F)CC2)n1 | 10.1016/j.bmcl.2011.09.033 | ||
| 9925905 | 151725 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 286 | 1 | 0 | 4 | 1.5 | Cc1cccc(C2=CS(=O)(=O)CCCS2(=O)=O)c1 | nan | ||
| CHEMBL3910434 | 151725 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 286 | 1 | 0 | 4 | 1.5 | Cc1cccc(C2=CS(=O)(=O)CCCS2(=O)=O)c1 | nan | ||
| 9796013 | 152740 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 290 | 1 | 0 | 4 | 1.4 | O=S1(=O)C=C(c2cccc(F)c2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3918185 | 152740 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 290 | 1 | 0 | 4 | 1.4 | O=S1(=O)C=C(c2cccc(F)c2)S(=O)(=O)CCC1 | nan | ||
| 57008825 | 159607 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 278 | 1 | 0 | 5 | 1.3 | O=S1(=O)C=C(c2cccs2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3973948 | 159607 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 278 | 1 | 0 | 5 | 1.3 | O=S1(=O)C=C(c2cccs2)S(=O)(=O)CCC1 | nan | ||
| 101061657 | 159897 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 278 | 1 | 0 | 5 | 1.3 | O=S1(=O)C=C(c2ccsc2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3976401 | 159897 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 278 | 1 | 0 | 5 | 1.3 | O=S1(=O)C=C(c2ccsc2)S(=O)(=O)CCC1 | nan | ||
| 91376438 | 150896 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 412 | 3 | 0 | 6 | 2.1 | O=S1(=O)C=C(c2ccc(S(=O)(=O)c3ccccc3)cc2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3903668 | 150896 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 412 | 3 | 0 | 6 | 2.1 | O=S1(=O)C=C(c2ccc(S(=O)(=O)c3ccccc3)cc2)S(=O)(=O)CCC1 | nan | ||
| 91000662 | 157458 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 286 | 1 | 0 | 4 | 1.5 | Cc1ccccc1C1=CS(=O)(=O)CCCS1(=O)=O | nan | ||
| CHEMBL3955804 | 157458 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 286 | 1 | 0 | 4 | 1.5 | Cc1ccccc1C1=CS(=O)(=O)CCCS1(=O)=O | nan | ||
| 57401227 | 75604 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 506 | 8 | 2 | 8 | 5.6 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCC(N4CCCCC4)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1922024 | 75604 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 506 | 8 | 2 | 8 | 5.6 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCC(N4CCCCC4)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| 6124 | 8221 | 1 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 286 | 1 | 0 | 4 | 1.5 | Cc1ccc(cc1)C1=CS(=O)(=O)CCCS1(=O)=O | nan | ||
| 9947811 | 8221 | 1 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 286 | 1 | 0 | 4 | 1.5 | Cc1ccc(cc1)C1=CS(=O)(=O)CCCS1(=O)=O | nan | ||
| CHEMBL3906195 | 8221 | 1 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 286 | 1 | 0 | 4 | 1.5 | Cc1ccc(cc1)C1=CS(=O)(=O)CCCS1(=O)=O | nan | ||
| 91273519 | 150267 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 306 | 1 | 0 | 4 | 1.9 | O=S1(=O)C=C(c2ccc(Cl)cc2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3898656 | 150267 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 306 | 1 | 0 | 4 | 1.9 | O=S1(=O)C=C(c2ccc(Cl)cc2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL475845 | 220822 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](CS(=O)(=O)O)C(C)=O)NC(=O)[C@H]([C@@H](C)CC)NC1=O | 10.1016/j.bmcl.2008.10.104 | ||||
| 9862765 | 154147 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 340 | 1 | 0 | 4 | 2.2 | O=S1(=O)C=C(c2ccc(C(F)(F)F)cc2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3929524 | 154147 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 340 | 1 | 0 | 4 | 2.2 | O=S1(=O)C=C(c2ccc(C(F)(F)F)cc2)S(=O)(=O)CCC1 | nan | ||
| 9884806 | 155693 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 350 | 1 | 0 | 4 | 2.0 | O=S1(=O)C=C(c2ccc(Br)cc2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3941767 | 155693 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 350 | 1 | 0 | 4 | 2.0 | O=S1(=O)C=C(c2ccc(Br)cc2)S(=O)(=O)CCC1 | nan | ||
| 9795483 | 152074 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 272 | 1 | 0 | 4 | 1.2 | O=S1(=O)C=C(c2ccccc2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3913089 | 152074 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 272 | 1 | 0 | 4 | 1.2 | O=S1(=O)C=C(c2ccccc2)S(=O)(=O)CCC1 | nan | ||
| 13651848 | 153811 | 7 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 258 | 1 | 0 | 4 | 0.8 | O=S1(=O)C=C(c2ccccc2)S(=O)(=O)CC1 | nan | ||
| CHEMBL3926775 | 153811 | 7 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 258 | 1 | 0 | 4 | 0.8 | O=S1(=O)C=C(c2ccccc2)S(=O)(=O)CC1 | nan | ||
| 9798779 | 159447 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 356 | 2 | 0 | 5 | 2.1 | O=S1(=O)C=C(c2cccc(OC(F)(F)F)c2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3972601 | 159447 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 356 | 2 | 0 | 5 | 2.1 | O=S1(=O)C=C(c2cccc(OC(F)(F)F)c2)S(=O)(=O)CCC1 | nan | ||
| 57395993 | 75577 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 455 | 9 | 3 | 7 | 6.3 | COc1ccc(Nc2cc(Nc3ccc(OC(F)F)cc3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1921995 | 75577 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 455 | 9 | 3 | 7 | 6.3 | COc1ccc(Nc2cc(Nc3ccc(OC(F)F)cc3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| 57401228 | 75605 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 538 | 7 | 2 | 9 | 5.6 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCN(C(=O)OC(C)(C)C)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1922025 | 75605 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 538 | 7 | 2 | 9 | 5.6 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCN(C(=O)OC(C)(C)C)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL514318 | 222374 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]([C@@H](C)CC)NC1=O | 10.1016/j.bmcl.2008.10.104 | ||||
| 6604909 | 71056 | 16 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 393 | 9 | 1 | 3 | 5.0 | CN(CC[C@@H](Oc1ccc(-c2ccccc2)cc1)c1ccc(F)cc1)CC(=O)O | 10.1016/j.bmcl.2008.10.104 | ||
| 86306255 | 71056 | 16 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 393 | 9 | 1 | 3 | 5.0 | CN(CC[C@@H](Oc1ccc(-c2ccccc2)cc1)c1ccc(F)cc1)CC(=O)O | 10.1016/j.bmcl.2008.10.104 | ||
| CHEMBL180966 | 71056 | 16 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 393 | 9 | 1 | 3 | 5.0 | CN(CC[C@@H](Oc1ccc(-c2ccccc2)cc1)c1ccc(F)cc1)CC(=O)O | 10.1016/j.bmcl.2008.10.104 | ||
| CHEMBL515145 | 222376 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@H](C)[C@@H](C)O)NC(=O)[C@H]([C@@H](C)CC)NC1=O | 10.1016/j.bmcl.2008.10.104 | ||||
| 57397798 | 75583 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 527 | 6 | 1 | 8 | 5.4 | COc1ccc(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1922000 | 75583 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 527 | 6 | 1 | 8 | 5.4 | COc1ccc(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| 57394304 | 75519 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 429 | 6 | 2 | 6 | 5.9 | FC(F)(F)Oc1cccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1921903 | 75519 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 429 | 6 | 2 | 6 | 5.9 | FC(F)(F)Oc1cccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1 | 10.1016/j.bmcl.2011.09.033 | ||
| 91167010 | 157454 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 322 | 1 | 0 | 4 | 2.4 | O=S1(=O)C=C(c2cccc3ccccc23)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3955764 | 157454 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 322 | 1 | 0 | 4 | 2.4 | O=S1(=O)C=C(c2cccc3ccccc23)S(=O)(=O)CCC1 | nan | ||
| 57401226 | 75601 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 451 | 9 | 3 | 7 | 6.1 | COc1ccc(Nc2nc(NCC3CCCCC3)cc(Nc3ccc(OC)c(F)c3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1922021 | 75601 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 451 | 9 | 3 | 7 | 6.1 | COc1ccc(Nc2nc(NCC3CCCCC3)cc(Nc3ccc(OC)c(F)c3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| 57395996 | 75602 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 502 | 8 | 2 | 10 | 4.2 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCN(c4ncccn4)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1922022 | 75602 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 502 | 8 | 2 | 10 | 4.2 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCN(c4ncccn4)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| 57395994 | 75584 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 525 | 5 | 1 | 7 | 6.0 | Cc1ccc(C)c(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)c1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1922001 | 75584 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 525 | 5 | 1 | 7 | 6.0 | Cc1ccc(C)c(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)c1 | 10.1016/j.bmcl.2011.09.033 | ||
| 9860799 | 156044 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 290 | 1 | 0 | 4 | 1.4 | O=S1(=O)C=C(c2ccc(F)cc2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3944461 | 156044 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 290 | 1 | 0 | 4 | 1.4 | O=S1(=O)C=C(c2ccc(F)cc2)S(=O)(=O)CCC1 | nan | ||
| 9799171 | 157790 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 364 | 3 | 0 | 5 | 3.0 | O=S1(=O)C=C(c2ccc(Oc3ccccc3)cc2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3958445 | 157790 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 364 | 3 | 0 | 5 | 3.0 | O=S1(=O)C=C(c2ccc(Oc3ccccc3)cc2)S(=O)(=O)CCC1 | nan | ||
| 91591245 | 150844 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 290 | 1 | 0 | 4 | 1.4 | O=S1(=O)C=C(c2ccccc2F)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3903219 | 150844 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 290 | 1 | 0 | 4 | 1.4 | O=S1(=O)C=C(c2ccccc2F)S(=O)(=O)CCC1 | nan | ||
| 9861140 | 155980 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 300 | 2 | 0 | 4 | 1.8 | CCc1ccc(C2=CS(=O)(=O)CCCS2(=O)=O)cc1 | nan | ||
| CHEMBL3943955 | 155980 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 300 | 2 | 0 | 4 | 1.8 | CCc1ccc(C2=CS(=O)(=O)CCCS2(=O)=O)cc1 | nan | ||
| 101061653 | 155684 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 392 | 3 | 0 | 6 | 2.4 | O=C(Oc1ccccc1)c1cccc(C2=CS(=O)(=O)CCCS2(=O)=O)c1 | nan | ||
| CHEMBL3941717 | 155684 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 392 | 3 | 0 | 6 | 2.4 | O=C(Oc1ccccc1)c1cccc(C2=CS(=O)(=O)CCCS2(=O)=O)c1 | nan | ||
| 57394236 | 75575 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 391 | 7 | 2 | 7 | 4.6 | COc1ccc(Nc2cc(Nc3cccc(OC)c3)nc(N3CCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1921993 | 75575 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 391 | 7 | 2 | 7 | 4.6 | COc1ccc(Nc2cc(Nc3cccc(OC)c3)nc(N3CCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| 90940684 | 152796 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 356 | 2 | 0 | 5 | 2.1 | O=S1(=O)C=C(c2ccc(OC(F)(F)F)cc2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3918646 | 152796 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 356 | 2 | 0 | 5 | 2.1 | O=S1(=O)C=C(c2ccc(OC(F)(F)F)cc2)S(=O)(=O)CCC1 | nan | ||
| 57401221 | 75578 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 455 | 9 | 3 | 7 | 6.3 | COc1ccc(Nc2cc(Nc3cccc(OC(F)F)c3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1921996 | 75578 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 455 | 9 | 3 | 7 | 6.3 | COc1ccc(Nc2cc(Nc3cccc(OC(F)F)c3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| 57390716 | 75598 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 437 | 7 | 2 | 7 | 5.5 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1922016 | 75598 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 437 | 7 | 2 | 7 | 5.5 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| 57394237 | 75580 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 419 | 8 | 3 | 7 | 5.7 | COc1ccc(Nc2cc(Nc3cccc(OC)c3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1921998 | 75580 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 419 | 8 | 3 | 7 | 5.7 | COc1ccc(Nc2cc(Nc3cccc(OC)c3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| 91414022 | 153197 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 350 | 1 | 0 | 4 | 2.0 | O=S1(=O)C=C(c2ccccc2Br)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3921852 | 153197 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 350 | 1 | 0 | 4 | 2.0 | O=S1(=O)C=C(c2ccccc2Br)S(=O)(=O)CCC1 | nan | ||
| 91016278 | 152850 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 340 | 1 | 0 | 4 | 2.2 | O=S1(=O)C=C(c2ccccc2C(F)(F)F)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3919125 | 152850 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 340 | 1 | 0 | 4 | 2.2 | O=S1(=O)C=C(c2ccccc2C(F)(F)F)S(=O)(=O)CCC1 | nan | ||
| 9861729 | 151161 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 316 | 3 | 0 | 5 | 1.6 | CCOc1ccc(C2=CS(=O)(=O)CCCS2(=O)=O)cc1 | nan | ||
| CHEMBL3905888 | 151161 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 316 | 3 | 0 | 5 | 1.6 | CCOc1ccc(C2=CS(=O)(=O)CCCS2(=O)=O)cc1 | nan | ||
| 57392517 | 75579 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 473 | 8 | 3 | 7 | 6.6 | COc1ccc(Nc2cc(Nc3ccc(OC(F)(F)F)cc3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1921997 | 75579 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 473 | 8 | 3 | 7 | 6.6 | COc1ccc(Nc2cc(Nc3ccc(OC(F)(F)F)cc3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| 9884699 | 149394 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 348 | 2 | 0 | 4 | 2.9 | O=S1(=O)C=C(c2ccc(-c3ccccc3)cc2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3891488 | 149394 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 348 | 2 | 0 | 4 | 2.9 | O=S1(=O)C=C(c2ccc(-c3ccccc3)cc2)S(=O)(=O)CCC1 | nan | ||
| 91055417 | 154591 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 340 | 1 | 0 | 4 | 2.2 | O=S1(=O)C=C(c2cccc(C(F)(F)F)c2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3932833 | 154591 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 340 | 1 | 0 | 4 | 2.2 | O=S1(=O)C=C(c2cccc(C(F)(F)F)c2)S(=O)(=O)CCC1 | nan | ||
| 57399458 | 75585 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 545 | 6 | 1 | 8 | 5.5 | COc1ccc(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)cc1F | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1922002 | 75585 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 545 | 6 | 1 | 8 | 5.5 | COc1ccc(Nc2cc(N3CCCCC3)nc(N3CCCN(c4ncccc4C(F)(F)F)CC3)n2)cc1F | 10.1016/j.bmcl.2011.09.033 | ||
| 9948494 | 151219 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 306 | 1 | 0 | 4 | 1.9 | O=S1(=O)C=C(c2ccccc2Cl)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3906449 | 151219 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 306 | 1 | 0 | 4 | 1.9 | O=S1(=O)C=C(c2ccccc2Cl)S(=O)(=O)CCC1 | nan | ||
| 57395992 | 75573 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 393 | 6 | 2 | 6 | 5.1 | COc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1F | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1921991 | 75573 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 393 | 6 | 2 | 6 | 5.1 | COc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1F | 10.1016/j.bmcl.2011.09.033 | ||
| 57401225 | 75600 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 437 | 7 | 2 | 7 | 5.4 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCC(C)C3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1922019 | 75600 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 437 | 7 | 2 | 7 | 5.4 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCCC(C)C3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| 57399457 | 75581 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 473 | 8 | 3 | 7 | 6.6 | COc1ccc(Nc2cc(Nc3cccc(OC(F)(F)F)c3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1921999 | 75581 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 473 | 8 | 3 | 7 | 6.6 | COc1ccc(Nc2cc(Nc3cccc(OC(F)(F)F)c3)nc(NC3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| 57390718 | 75603 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 500 | 8 | 2 | 8 | 5.4 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCN(c4ccccc4)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1922023 | 75603 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 500 | 8 | 2 | 8 | 5.4 | COc1ccc(Nc2nc(Nc3ccc(OC)c(F)c3)cc(N3CCN(c4ccccc4)CC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| 57401220 | 75571 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 411 | 7 | 2 | 6 | 5.6 | FC(F)Oc1cccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1921989 | 75571 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 411 | 7 | 2 | 6 | 5.6 | FC(F)Oc1cccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)c1 | 10.1016/j.bmcl.2011.09.033 | ||
| 9843783 | 153076 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 398 | 1 | 0 | 4 | 1.8 | O=S1(=O)C=C(c2ccc(I)cc2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3920910 | 153076 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 398 | 1 | 0 | 4 | 1.8 | O=S1(=O)C=C(c2ccc(I)cc2)S(=O)(=O)CCC1 | nan | ||
| 134151208 | 158742 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 301 | 3 | 1 | 5 | 0.2 | NC(Cc1ccccc1)C1=CS(=O)(=O)CCS1(=O)=O | nan | ||
| CHEMBL3966583 | 158742 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 301 | 3 | 1 | 5 | 0.2 | NC(Cc1ccccc1)C1=CS(=O)(=O)CCS1(=O)=O | nan | ||
| 90761518 | 155630 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 1 | 0 | 4 | 1.8 | O=S1(=O)C=C(c2cccc(I)c2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3941261 | 155630 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 398 | 1 | 0 | 4 | 1.8 | O=S1(=O)C=C(c2cccc(I)c2)S(=O)(=O)CCC1 | nan | ||
| 57396058 | 75518 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 375 | 6 | 2 | 6 | 5.0 | COc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| CHEMBL1921902 | 75518 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 375 | 6 | 2 | 6 | 5.0 | COc1ccc(Nc2cc(Nc3ccccc3)nc(N3CCCCC3)n2)cc1 | 10.1016/j.bmcl.2011.09.033 | ||
| 9798525 | 154801 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 350 | 1 | 0 | 4 | 2.0 | O=S1(=O)C=C(c2cccc(Br)c2)S(=O)(=O)CCC1 | nan | ||
| CHEMBL3934499 | 154801 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 350 | 1 | 0 | 4 | 2.0 | O=S1(=O)C=C(c2cccc(Br)c2)S(=O)(=O)CCC1 | nan | ||
| 9904495 | 160306 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 302 | 2 | 0 | 5 | 1.2 | COc1cccc(C2=CS(=O)(=O)CCCS2(=O)=O)c1 | nan | ||
| CHEMBL3979946 | 160306 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 302 | 2 | 0 | 5 | 1.2 | COc1cccc(C2=CS(=O)(=O)CCCS2(=O)=O)c1 | nan | ||
| CHEMBL451169 | 220745 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cn(OC)c3ccccc23)NC(=O)[C@H](CCCCC(C)=O)NC(=O)[C@H]2CCCCN2C1=O | 10.1016/j.bmcl.2008.10.104 | ||||
| CHEMBL503473 | 220946 | 14 | None | 60 | 3 | Human | 10.0 | pKd | = | 10 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O | 10.1021/jm801088x | ||||
| CHEMBL526003 | 222448 | 29 | None | 10 | 3 | Human | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(N)=O | 10.1021/jm801088x | ||||
| 155817464 | 8281 | 0 | None | 5 | 4 | Human | 9.4 | pKd | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm801088x | ||||
| 3866 | 8281 | 0 | None | 5 | 4 | Human | 9.4 | pKd | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm801088x | ||||
| 44587986 | 8281 | 0 | None | 5 | 4 | Human | 9.4 | pKd | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm801088x | ||||
| 91934870 | 8281 | 0 | None | 5 | 4 | Human | 9.4 | pKd | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm801088x | ||||
| CHEMBL499179 | 8281 | 0 | None | 5 | 4 | Human | 9.4 | pKd | = | 9.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm801088x | ||||
| 71717271 | 92865 | 1 | None | 1 | 3 | Human | 4.9 | pKd | = | 4.9 | Binding | ChEMBL | 678 | 13 | 4 | 7 | 6.5 | Cc1cc(=O)oc2cc(NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC3CCCCC3)NC(=O)OCC3c4ccccc4-c4ccccc43)ccc12 | 10.1021/jm801088x | ||
| CHEMBL2309599 | 92865 | 1 | None | 1 | 3 | Human | 4.9 | pKd | = | 4.9 | Binding | ChEMBL | 678 | 13 | 4 | 7 | 6.5 | Cc1cc(=O)oc2cc(NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC3CCCCC3)NC(=O)OCC3c4ccccc4-c4ccccc43)ccc12 | 10.1021/jm801088x | ||
| 16132180 | 8505 | 21 | None | -1 | 8 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm801088x | ||||
| 16133822 | 8505 | 21 | None | -1 | 8 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm801088x | ||||
| 6087 | 8505 | 21 | None | -1 | 8 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm801088x | ||||
| CHEMBL499980 | 8505 | 21 | None | -1 | 8 | Human | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm801088x | ||||
| 24748735 | 8536 | 1 | None | -3 | 2 | Human | 4.5 | pKd | = | 4.5 | Binding | ChEMBL | 988 | 12 | 7 | 15 | 4.2 | NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 | 10.1021/jm801088x | ||
| 6119 | 8536 | 1 | None | -3 | 2 | Human | 4.5 | pKd | = | 4.5 | Binding | ChEMBL | 988 | 12 | 7 | 15 | 4.2 | NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 | 10.1021/jm801088x | ||
| CHEMBL1187471 | 8536 | 1 | None | -3 | 2 | Human | 4.5 | pKd | = | 4.5 | Binding | ChEMBL | 988 | 12 | 7 | 15 | 4.2 | NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 | 10.1021/jm801088x | ||
| CHEMBL506210 | 220984 | 0 | None | -478 | 2 | Human | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm801088x | ||||
| CHEMBL503473 | 220946 | 14 | None | 60 | 3 | Human | 11.0 | pKi | = | 11 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O | 10.1021/jm9018349 | ||||
| CHEMBL501079 | 220909 | 13 | None | 11 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1021/jm9018349 | ||||
| CHEMBL526003 | 222448 | 29 | None | 10 | 3 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(N)=O | 10.1021/jm9018349 | ||||
| CHEMBL604373 | 222601 | 3 | None | 7 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(N)=O | 10.1021/jm9018349 | ||||
| CHEMBL604990 | 222603 | 24 | None | 15 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](C)C(N)=O | 10.1021/jm9018349 | ||||
| CHEMBL592413 | 222588 | 0 | None | 4 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O | 10.1021/jm9018349 | ||||
| CHEMBL501079 | 220909 | 13 | None | 11 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1021/jm8007618 | ||||
| 44563951 | 195716 | 0 | None | 60 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 1874 | 63 | 25 | 27 | -5.8 | CNCC(=O)O[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)O | 10.1021/jm801397w | ||
| CHEMBL508036 | 195716 | 0 | None | 60 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 1874 | 63 | 25 | 27 | -5.8 | CNCC(=O)O[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)O | 10.1021/jm801397w | ||
| CHEMBL525055 | 222413 | 0 | None | 60 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)O | 10.1021/jm801088x | ||||
| CHEMBL501079 | 220909 | 13 | None | 11 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1016/j.ejmech.2013.01.044 | ||||
| 44563958 | 195532 | 0 | None | 40 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 2122 | 78 | 25 | 32 | -5.9 | CNCC(=O)O[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCNC(=O)COCCOCCOCCOCCOC)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)O | 10.1021/jm801397w | ||
| CHEMBL505299 | 195532 | 0 | None | 40 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 2122 | 78 | 25 | 32 | -5.9 | CNCC(=O)O[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCNC(=O)COCCOCCOCCOCCOC)C(=O)N[C@@H](CCCCN)C(N)=O)[C@@H](C)O | 10.1021/jm801397w | ||
| CHEMBL508083 | 221487 | 0 | None | 25 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C)C(=O)N[C@H](C(N)=O)C(C)C | 10.1021/jm801088x | ||||
| 44563952 | 195457 | 0 | None | 20 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 2000 | 70 | 25 | 27 | -3.2 | CCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | ||
| CHEMBL503900 | 195457 | 0 | None | 20 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 2000 | 70 | 25 | 27 | -3.2 | CCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | ||
| 25180491 | 200230 | 0 | None | 16 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCCN)NC(=O)[C@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| CHEMBL526500 | 200230 | 0 | None | 16 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCCCN)NC(=O)[C@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| 44563953 | 183579 | 0 | None | 11 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 2028 | 72 | 25 | 27 | -2.5 | CCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | ||
| CHEMBL460706 | 183579 | 0 | None | 11 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 2028 | 72 | 25 | 27 | -2.5 | CCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | ||
| 44563954 | 195691 | 0 | None | 11 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 2056 | 74 | 25 | 27 | -1.7 | CCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | ||
| CHEMBL507733 | 195691 | 0 | None | 11 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 2056 | 74 | 25 | 27 | -1.7 | CCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | ||
| 45104656 | 205351 | 0 | None | 9 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 2082 | 76 | 25 | 25 | 0.3 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | ||
| CHEMBL578317 | 205351 | 0 | None | 9 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 2082 | 76 | 25 | 25 | 0.3 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | ||
| 25180487 | 200181 | 0 | None | 11 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(N)=O | 10.1021/jm801088x | ||
| CHEMBL525755 | 200181 | 0 | None | 11 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(N)=O | 10.1021/jm801088x | ||
| 45104655 | 205406 | 0 | None | 3 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 2111 | 77 | 26 | 26 | -0.4 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | ||
| CHEMBL578910 | 205406 | 0 | None | 3 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 2111 | 77 | 26 | 26 | -0.4 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | ||
| 71717271 | 92865 | 1 | None | 1 | 3 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 678 | 13 | 4 | 7 | 6.5 | Cc1cc(=O)oc2cc(NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC3CCCCC3)NC(=O)OCC3c4ccccc4-c4ccccc43)ccc12 | 10.1021/jm9018349 | ||
| CHEMBL2309599 | 92865 | 1 | None | 1 | 3 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 678 | 13 | 4 | 7 | 6.5 | Cc1cc(=O)oc2cc(NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC3CCCCC3)NC(=O)OCC3c4ccccc4-c4ccccc43)ccc12 | 10.1021/jm9018349 | ||
| 44563955 | 200121 | 0 | None | 7 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 2084 | 76 | 25 | 27 | -0.9 | CCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | ||
| CHEMBL524678 | 200121 | 0 | None | 7 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 2084 | 76 | 25 | 27 | -0.9 | CCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | ||
| 25180489 | 195039 | 0 | None | 5 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 2097 | 77 | 26 | 26 | -0.8 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | ||
| CHEMBL499807 | 195039 | 0 | None | 5 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 2097 | 77 | 26 | 26 | -0.8 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | ||
| 25180496 | 195500 | 0 | None | 2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 2153 | 81 | 26 | 26 | 0.8 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| CHEMBL504758 | 195500 | 0 | None | 2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 2153 | 81 | 26 | 26 | 0.8 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| 25180488 | 195145 | 0 | None | 4 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| CHEMBL501306 | 195145 | 0 | None | 4 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| 25180492 | 195670 | 0 | None | 2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 2014 | 77 | 26 | 25 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| CHEMBL507373 | 195670 | 0 | None | 2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 2014 | 77 | 26 | 25 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| 25180490 | 69959 | 0 | None | 19 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 2195 | 78 | 32 | 26 | -3.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O | 10.1021/jm801088x | ||
| 91934869 | 69959 | 0 | None | 19 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 2195 | 78 | 32 | 26 | -3.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O | 10.1021/jm801088x | ||
| CHEMBL1790054 | 69959 | 0 | None | 19 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 2195 | 78 | 32 | 26 | -3.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O | 10.1021/jm801088x | ||
| 24760995 | 205366 | 0 | None | 14 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 2112 | 78 | 26 | 26 | 0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)O | 10.1021/jm9018349 | ||
| CHEMBL578514 | 205366 | 0 | None | 14 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 2112 | 78 | 26 | 26 | 0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)O | 10.1021/jm9018349 | ||
| 24760995 | 205366 | 0 | None | 14 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 2112 | 78 | 26 | 26 | 0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)O | 10.1021/jm9018349 | ||
| CHEMBL578514 | 205366 | 0 | None | 14 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 2112 | 78 | 26 | 26 | 0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)O | 10.1021/jm9018349 | ||
| 44563956 | 195668 | 0 | None | 14 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 2112 | 78 | 25 | 27 | -0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | ||
| CHEMBL507353 | 195668 | 0 | None | 14 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 2112 | 78 | 25 | 27 | -0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | ||
| 44587984 | 200143 | 4 | None | 14 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| CHEMBL525023 | 200143 | 4 | None | 14 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| CHEMBL2324950 | 216307 | 0 | None | 4 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@]1(C)CCC/C=C\CCC[C@@](C)(C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC1=O)[C@@H](C)O | 10.1016/j.bmc.2012.10.026 | ||||
| 25180498 | 200135 | 0 | None | 4 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 1957 | 75 | 25 | 24 | 0.3 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| CHEMBL524892 | 200135 | 0 | None | 4 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 1957 | 75 | 25 | 24 | 0.3 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| 24748735 | 8536 | 1 | None | -3 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 988 | 12 | 7 | 15 | 4.2 | NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 | 10.1021/jm9018349 | ||
| 6119 | 8536 | 1 | None | -3 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 988 | 12 | 7 | 15 | 4.2 | NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 | 10.1021/jm9018349 | ||
| CHEMBL1187471 | 8536 | 1 | None | -3 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 988 | 12 | 7 | 15 | 4.2 | NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 | 10.1021/jm9018349 | ||
| 45104657 | 208240 | 0 | None | -18 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 2054 | 76 | 25 | 25 | 0.3 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | ||
| CHEMBL604991 | 208240 | 0 | None | -18 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 2054 | 76 | 25 | 25 | 0.3 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | ||
| CHEMBL2324949 | 216306 | 0 | None | 3 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@]1(C)CCC/C=C/CCC[C@@](C)(C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CNC1=O)[C@@H](C)O | 10.1016/j.bmc.2012.10.026 | ||||
| 25180495 | 195611 | 0 | None | -8 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 2040 | 75 | 25 | 25 | 0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | ||
| CHEMBL506495 | 195611 | 0 | None | -8 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 2040 | 75 | 25 | 25 | 0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm9018349 | ||
| 25180495 | 195611 | 0 | None | -8 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 2040 | 75 | 25 | 25 | 0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| CHEMBL506495 | 195611 | 0 | None | -8 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 2040 | 75 | 25 | 25 | 0.1 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| 44563957 | 179521 | 0 | None | 3 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 2140 | 80 | 25 | 27 | 0.7 | CCCCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | ||
| CHEMBL450827 | 179521 | 0 | None | 3 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 2140 | 80 | 25 | 27 | 0.7 | CCCCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)OC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801397w | ||
| 25180497 | 200364 | 0 | None | 5 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 2213 | 87 | 29 | 28 | -0.4 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| CHEMBL526889 | 200364 | 0 | None | 5 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 2213 | 87 | 29 | 28 | -0.4 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| 25180489 | 195039 | 0 | None | 5 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 2097 | 77 | 26 | 26 | -0.8 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| CHEMBL499807 | 195039 | 0 | None | 5 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 2097 | 77 | 26 | 26 | -0.8 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| CHEMBL592415 | 222589 | 0 | None | -5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm9018349 | ||||
| CHEMBL592170 | 222587 | 0 | None | -2 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)[C@@H](C)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(N)=O)[C@@H](C)O | 10.1021/jm9018349 | ||||
| 25180494 | 195509 | 0 | None | 4 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| CHEMBL504914 | 195509 | 0 | None | 4 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 2111 | 78 | 26 | 26 | -0.5 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O | 10.1021/jm801088x | ||
| 25180486 | 200355 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 1935 | 66 | 23 | 23 | -0.4 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(N)=O | 10.1021/jm801088x | ||
| 44587983 | 200355 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 1935 | 66 | 23 | 23 | -0.4 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(N)=O | 10.1021/jm801088x | ||
| CHEMBL526862 | 200355 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 1935 | 66 | 23 | 23 | -0.4 | CCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC)[C@@H](C)O)C(N)=O | 10.1021/jm801088x | ||
| CHEMBL578710 | 222557 | 25 | None | -501 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(N)=O | 10.1021/jm9018349 | ||||
| 155817484 | 8496 | 0 | None | -1 | 6 | Rat | 10.1 | pKd | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 155817484 | 8496 | 0 | None | -1 | 6 | Rat | 10.1 | pKd | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 155817484 | 8496 | 0 | None | -1 | 6 | Rat | 10.1 | pKd | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 155817484 | 8496 | 0 | None | -1 | 6 | Rat | 10.1 | pKd | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 9578584 | ||||
| 155817484 | 8496 | 0 | None | -1 | 6 | Rat | 10.1 | pKd | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 155817484 | 8496 | 0 | None | -1 | 6 | Rat | 10.1 | pKd | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 6117 | 8496 | 0 | None | -1 | 6 | Rat | 10.1 | pKd | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 6117 | 8496 | 0 | None | -1 | 6 | Rat | 10.1 | pKd | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 6117 | 8496 | 0 | None | -1 | 6 | Rat | 10.1 | pKd | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 6117 | 8496 | 0 | None | -1 | 6 | Rat | 10.1 | pKd | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 9578584 | ||||
| 6117 | 8496 | 0 | None | -1 | 6 | Rat | 10.1 | pKd | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 6117 | 8496 | 0 | None | -1 | 6 | Rat | 10.1 | pKd | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 6129 | 8496 | 0 | None | -1 | 6 | Rat | 10.1 | pKd | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 6129 | 8496 | 0 | None | -1 | 6 | Rat | 10.1 | pKd | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 6129 | 8496 | 0 | None | -1 | 6 | Rat | 10.1 | pKd | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 6129 | 8496 | 0 | None | -1 | 6 | Rat | 10.1 | pKd | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 9578584 | ||||
| 6129 | 8496 | 0 | None | -1 | 6 | Rat | 10.1 | pKd | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 9685625 | ||||
| 6129 | 8496 | 0 | None | -1 | 6 | Rat | 10.1 | pKd | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 6098 | 10481 | 0 | None | - | 1 | Rat | 5.8 | pKd | = | 5.8 | Binding | Guide to Pharmacology | None | None | None | None | 8738882 | ||||
| 6085 | 8503 | 0 | None | - | 1 | Rat | 6.9 | pKd | = | 6.9 | Binding | Guide to Pharmacology | None | None | None | None | 8738882 | ||||
| 6096 | 8540 | 0 | None | - | 1 | Rat | 8.2 | pKd | = | 8.2 | Binding | Guide to Pharmacology | None | None | None | None | 8738882 | ||||
| 155817484 | 8496 | 0 | None | 1 | 6 | Human | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 6117 | 8496 | 0 | None | 1 | 6 | Human | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 6129 | 8496 | 0 | None | 1 | 6 | Human | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 155817484 | 8496 | 0 | None | -1 | 6 | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8738882 | ||||
| 6117 | 8496 | 0 | None | -1 | 6 | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8738882 | ||||
| 6129 | 8496 | 0 | None | -1 | 6 | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 8738882 | ||||
| 6097 | 10480 | 0 | None | - | 1 | Rat | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | None | None | None | None | 8738882 | ||||
| 155817484 | 8496 | 0 | None | 1 | 6 | Human | 9.8 | pKd | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 6117 | 8496 | 0 | None | 1 | 6 | Human | 9.8 | pKd | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 6129 | 8496 | 0 | None | 1 | 6 | Human | 9.8 | pKd | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| None | 222840 | 0 | 125I-GALANIN | -11 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 418 | 8 | 0 | 4 | 4.3 | CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl | None | ||
| None | 222840 | 0 | 125I-GALANIN | -1 | 6 | Rat | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 418 | 8 | 0 | 4 | 4.3 | CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl | None | ||
| None | 222840 | 0 | 125I-GALANIN | -1 | 6 | Rat | 9.0 | pKi | = | 9 | Binding | PDSP KiDatabase | 418 | 8 | 0 | 4 | 4.3 | CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl | None | ||
| None | 222840 | 0 | 125I-GALANIN | -1 | 6 | Rat | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 418 | 8 | 0 | 4 | 4.3 | CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl | None | ||
| None | 222840 | 0 | 125I-h Galanin | -11 | 6 | Human | 6.6 | pKi | = | 6.6 | Binding | PDSP KiDatabase | 418 | 8 | 0 | 4 | 4.3 | CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl | None | ||
| None | 222840 | 0 | 125I-h Galanin | -11 | 6 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 418 | 8 | 0 | 4 | 4.3 | CC1=CC=C(C=C1)OCCN(C2=CC=CC=C2OC)C(=O)CN3CCCCC3.Cl | None | ||
| 16131409 | 8504 | 0 | 125I-GALANIN | -5 | 3 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
| 6086 | 8504 | 0 | 125I-GALANIN | -5 | 3 | Rat | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | None | None | None | None | None | ||||
| 155817484 | 8496 | 0 | None | 1 | 6 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 155817484 | 8496 | 0 | None | 1 | 6 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| 155817484 | 8496 | 0 | None | 1 | 6 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 6117 | 8496 | 0 | None | 1 | 6 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 6117 | 8496 | 0 | None | 1 | 6 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| 6117 | 8496 | 0 | None | 1 | 6 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 6129 | 8496 | 0 | None | 1 | 6 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 6129 | 8496 | 0 | None | 1 | 6 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| 6129 | 8496 | 0 | None | 1 | 6 | Human | 10.1 | pKi | = | 10.1 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 24748735 | 8536 | 1 | None | -3 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | Guide to Pharmacology | 988 | 12 | 7 | 15 | 4.2 | NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 | 15240875 | ||
| 24748735 | 8536 | 1 | None | -3 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | Guide to Pharmacology | 988 | 12 | 7 | 15 | 4.2 | NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 | 15944006 | ||
| 6119 | 8536 | 1 | None | -3 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | Guide to Pharmacology | 988 | 12 | 7 | 15 | 4.2 | NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 | 15240875 | ||
| 6119 | 8536 | 1 | None | -3 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | Guide to Pharmacology | 988 | 12 | 7 | 15 | 4.2 | NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 | 15944006 | ||
| CHEMBL1187471 | 8536 | 1 | None | -3 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | Guide to Pharmacology | 988 | 12 | 7 | 15 | 4.2 | NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 | 15240875 | ||
| CHEMBL1187471 | 8536 | 1 | None | -3 | 2 | Human | 4.5 | pKi | = | 4.5 | Binding | Guide to Pharmacology | 988 | 12 | 7 | 15 | 4.2 | NCCCC[C@@H](C(=O)OC)NC(=O)[C@]1(C)NC(=O)c2nc(oc2C)[C@@](C)(NC(=O)c2nc([C@](NC(=O)c3nc1oc3C)(C)C(=O)NCC1CCCCC1)oc2C)C(=O)NC1c2ccccc2c2c1cccc2 | 15944006 | ||
| 6074 | 9220 | 0 | None | -467 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | Guide to Pharmacology | None | None | None | None | 23192661 | ||||
| 5311268 | 8537 | 0 | None | 2 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | Guide to Pharmacology | 678 | 13 | 4 | 7 | 6.5 | NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1 | 15240875 | ||
| 5311268 | 8537 | 0 | None | 2 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | Guide to Pharmacology | 678 | 13 | 4 | 7 | 6.5 | NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1 | 15944006 | ||
| 6118 | 8537 | 0 | None | 2 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | Guide to Pharmacology | 678 | 13 | 4 | 7 | 6.5 | NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1 | 15240875 | ||
| 6118 | 8537 | 0 | None | 2 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | Guide to Pharmacology | 678 | 13 | 4 | 7 | 6.5 | NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1 | 15944006 | ||
| CHEMBL592414 | 8537 | 0 | None | 2 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | Guide to Pharmacology | 678 | 13 | 4 | 7 | 6.5 | NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1 | 15240875 | ||
| CHEMBL592414 | 8537 | 0 | None | 2 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | Guide to Pharmacology | 678 | 13 | 4 | 7 | 6.5 | NCCCC[C@@H](C(=O)Nc1ccc2c(c1)oc(=O)cc2C)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2c2c1cccc2)CC1CCCCC1 | 15944006 | ||
| 6103 | 9218 | 0 | None | -64 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | Guide to Pharmacology | None | None | None | None | 21333705 | ||||
| 6104 | 9219 | 0 | None | -380 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | Guide to Pharmacology | None | None | None | None | 21333705 | ||||
| 11758032 | 10318 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | Guide to Pharmacology | 584 | 5 | 3 | 12 | 0.8 | COC(=O)C1=C[C@@H](O)[C@H]([C@@H]([C@@H]1Oc1c(Cl)c(C)c(c2c1C(=O)[C@@]1(O2)C(=CC(=O)C=C1C(=O)OC)OC)Cl)O)O | None | ||
| 6128 | 10318 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | Guide to Pharmacology | 584 | 5 | 3 | 12 | 0.8 | COC(=O)C1=C[C@@H](O)[C@H]([C@@H]([C@@H]1Oc1c(Cl)c(C)c(c2c1C(=O)[C@@]1(O2)C(=CC(=O)C=C1C(=O)OC)OC)Cl)O)O | None | ||
| 6095 | 8520 | 0 | None | -45 | 6 | Rat | 6.2 | pKi | = | 6.2 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 6095 | 8520 | 0 | None | -45 | 6 | Rat | 6.2 | pKi | = | 6.2 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 6095 | 8520 | 0 | None | -45 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 6101 | 9216 | 0 | None | -89 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | Guide to Pharmacology | None | None | None | None | 19467704 | ||||
| 3900 | 9229 | 0 | None | -31 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | Guide to Pharmacology | None | None | None | None | None | ||||
| 6107 | 8533 | 0 | None | -8 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | Guide to Pharmacology | None | None | None | None | 19053761 | ||||
| 6109 | 9608 | 0 | None | -17 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | Guide to Pharmacology | None | None | None | None | 20121116 | ||||
| 155817465 | 8511 | 0 | None | -331 | 6 | Rat | 6.5 | pKi | = | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 9281594 | ||||
| 155817465 | 8511 | 0 | None | -331 | 6 | Rat | 6.5 | pKi | = | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 9405385 | ||||
| 155817465 | 8511 | 0 | None | -331 | 6 | Rat | 6.5 | pKi | = | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 9742938 | ||||
| 3876 | 8511 | 0 | None | -331 | 6 | Rat | 6.5 | pKi | = | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 9281594 | ||||
| 3876 | 8511 | 0 | None | -331 | 6 | Rat | 6.5 | pKi | = | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 9405385 | ||||
| 3876 | 8511 | 0 | None | -331 | 6 | Rat | 6.5 | pKi | = | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 9742938 | ||||
| 6075 | 8889 | 0 | None | -6 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | Guide to Pharmacology | None | None | None | None | 23600864 | ||||
| 6102 | 9217 | 0 | None | -3 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | Guide to Pharmacology | None | None | None | None | 21333705 | ||||
| 101927062 | 8495 | 22 | None | -10 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | None | None | None | None | 11983932 | ||||
| 155817445 | 8495 | 22 | None | -10 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | None | None | None | None | 11983932 | ||||
| 16133823 | 8495 | 22 | None | -10 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | None | None | None | None | 11983932 | ||||
| 3592 | 8495 | 22 | None | -10 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | None | None | None | None | 11983932 | ||||
| 44584852 | 8495 | 22 | None | -10 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | None | None | None | None | 11983932 | ||||
| 6090 | 8495 | 22 | None | -10 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | None | None | None | None | 11983932 | ||||
| 91898917 | 8495 | 22 | None | -10 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | None | None | None | None | 11983932 | ||||
| CHEMBL506553 | 8495 | 22 | None | -10 | 6 | Human | 7.3 | pKi | = | 7.3 | Binding | Guide to Pharmacology | None | None | None | None | 11983932 | ||||
| 155817465 | 8511 | 0 | None | -33 | 6 | Mouse | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | None | None | None | None | 9271210 | ||||
| 155817465 | 8511 | 0 | None | -33 | 6 | Mouse | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | None | None | None | None | 9832122 | ||||
| 3876 | 8511 | 0 | None | -33 | 6 | Mouse | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | None | None | None | None | 9271210 | ||||
| 3876 | 8511 | 0 | None | -33 | 6 | Mouse | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | None | None | None | None | 9832122 | ||||
| 155817487 | 8510 | 0 | None | -9 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 6130 | 8510 | 0 | None | -9 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 6076 | 8890 | 0 | None | -5 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | None | None | None | None | 23600864 | ||||
| 155817479 | 8517 | 0 | None | -9 | 6 | Rat | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 6083 | 8517 | 0 | None | -9 | 6 | Rat | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 155817487 | 8510 | 0 | None | -8 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 155817487 | 8510 | 0 | None | -8 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 6130 | 8510 | 0 | None | -8 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 6130 | 8510 | 0 | None | -8 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 155817479 | 8517 | 0 | None | -2 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 6083 | 8517 | 0 | None | -2 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 3899 | 9225 | 0 | None | -50 | 8 | Rat | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 3899 | 9225 | 0 | None | -50 | 8 | Rat | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 3899 | 9225 | 0 | None | -50 | 8 | Rat | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 16131409 | 8504 | 0 | None | -5 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 16131409 | 8504 | 0 | None | -5 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 6086 | 8504 | 0 | None | -5 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 6086 | 8504 | 0 | None | -5 | 3 | Rat | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 6115 | 8529 | 0 | None | 3 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | None | None | None | None | 19199479 | ||||
| 3896 | 9221 | 0 | None | -35 | 7 | Mouse | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | None | None | None | None | 9271210 | ||||
| 3896 | 9221 | 0 | None | -35 | 7 | Mouse | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | None | None | None | None | 9832122 | ||||
| 6105 | 8525 | 0 | None | 14 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 19053761 | ||||
| 16132180 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 16132180 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 16132180 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9281594 | ||||
| 16132180 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 16132180 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9405385 | ||||
| 16132180 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 16132180 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9742938 | ||||
| 16133822 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 16133822 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 16133822 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9281594 | ||||
| 16133822 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 16133822 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9405385 | ||||
| 16133822 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 16133822 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9742938 | ||||
| 6087 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 6087 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 6087 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9281594 | ||||
| 6087 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 6087 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9405385 | ||||
| 6087 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 6087 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9742938 | ||||
| CHEMBL499980 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| CHEMBL499980 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| CHEMBL499980 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9281594 | ||||
| CHEMBL499980 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| CHEMBL499980 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9405385 | ||||
| CHEMBL499980 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| CHEMBL499980 | 8505 | 21 | None | -1 | 8 | Rat | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 9742938 | ||||
| 3896 | 9221 | 0 | None | -24 | 7 | Rat | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 3896 | 9221 | 0 | None | -24 | 7 | Rat | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 9281594 | ||||
| 3896 | 9221 | 0 | None | -24 | 7 | Rat | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 3896 | 9221 | 0 | None | -24 | 7 | Rat | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 6114 | 8528 | 0 | None | 7 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 19199479 | ||||
| 155817463 | 7564 | 0 | None | -8 | 8 | Rat | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 155817463 | 7564 | 0 | None | -8 | 8 | Rat | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 155817463 | 7564 | 0 | None | -8 | 8 | Rat | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 3861 | 7564 | 0 | None | -8 | 8 | Rat | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 3861 | 7564 | 0 | None | -8 | 8 | Rat | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 3861 | 7564 | 0 | None | -8 | 8 | Rat | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 16132180 | 8505 | 21 | None | -1 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 19053761 | ||||
| 16132180 | 8505 | 21 | None | -1 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 16132180 | 8505 | 21 | None | -1 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| 16132180 | 8505 | 21 | None | -1 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 16133822 | 8505 | 21 | None | -1 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 19053761 | ||||
| 16133822 | 8505 | 21 | None | -1 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 16133822 | 8505 | 21 | None | -1 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| 16133822 | 8505 | 21 | None | -1 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 6087 | 8505 | 21 | None | -1 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 19053761 | ||||
| 6087 | 8505 | 21 | None | -1 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 6087 | 8505 | 21 | None | -1 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| 6087 | 8505 | 21 | None | -1 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| CHEMBL499980 | 8505 | 21 | None | -1 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 19053761 | ||||
| CHEMBL499980 | 8505 | 21 | None | -1 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| CHEMBL499980 | 8505 | 21 | None | -1 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| CHEMBL499980 | 8505 | 21 | None | -1 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 16132180 | 8505 | 21 | None | 1 | 8 | Mouse | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 9271210 | ||||
| 16132180 | 8505 | 21 | None | 1 | 8 | Mouse | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 9832122 | ||||
| 16133822 | 8505 | 21 | None | 1 | 8 | Mouse | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 9271210 | ||||
| 16133822 | 8505 | 21 | None | 1 | 8 | Mouse | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 9832122 | ||||
| 6087 | 8505 | 21 | None | 1 | 8 | Mouse | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 9271210 | ||||
| 6087 | 8505 | 21 | None | 1 | 8 | Mouse | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 9832122 | ||||
| CHEMBL499980 | 8505 | 21 | None | 1 | 8 | Mouse | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 9271210 | ||||
| CHEMBL499980 | 8505 | 21 | None | 1 | 8 | Mouse | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 9832122 | ||||
| 6113 | 8527 | 0 | None | 11 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | None | None | None | None | 19199479 | ||||
| 155817463 | 7564 | 0 | None | -5 | 8 | Mouse | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | None | None | None | None | 9271210 | ||||
| 155817463 | 7564 | 0 | None | -5 | 8 | Mouse | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | None | None | None | None | 9832122 | ||||
| 3861 | 7564 | 0 | None | -5 | 8 | Mouse | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | None | None | None | None | 9271210 | ||||
| 3861 | 7564 | 0 | None | -5 | 8 | Mouse | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | None | None | None | None | 9832122 | ||||
| 6112 | 8526 | 0 | None | 11 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | None | None | None | None | 19199479 | ||||
| 6106 | 8531 | 0 | None | 10 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | None | None | None | None | 23259957 | ||||
| 6111 | 8530 | 0 | None | 20 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | None | None | None | None | 19199479 | ||||
| 3897 | 9223 | 0 | None | -2 | 6 | Rat | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 3897 | 9223 | 0 | None | -2 | 6 | Rat | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 3899 | 9225 | 0 | None | -3 | 8 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 15944002 | ||||
| 3899 | 9225 | 0 | None | -3 | 8 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| 3899 | 9225 | 0 | None | -3 | 8 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 6116 | 8532 | 0 | None | 40 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 19199479 | ||||
| 6110 | 8534 | 0 | None | 60 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 19199479 | ||||
| 16133243 | 8497 | 0 | None | -2 | 8 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 15944002 | ||||
| 16133243 | 8497 | 0 | None | -2 | 8 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 19467704 | ||||
| 16133243 | 8497 | 0 | None | -2 | 8 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 21333705 | ||||
| 16133243 | 8497 | 0 | None | -2 | 8 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 16133243 | 8497 | 0 | None | -2 | 8 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 3593 | 8497 | 0 | None | -2 | 8 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 15944002 | ||||
| 3593 | 8497 | 0 | None | -2 | 8 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 19467704 | ||||
| 3593 | 8497 | 0 | None | -2 | 8 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 21333705 | ||||
| 3593 | 8497 | 0 | None | -2 | 8 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 3593 | 8497 | 0 | None | -2 | 8 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 3898 | 9224 | 0 | None | -1 | 7 | Rat | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 3898 | 9224 | 0 | None | -1 | 7 | Rat | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 3898 | 9224 | 0 | None | -1 | 7 | Rat | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 155817484 | 8496 | 0 | None | -1 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 155817484 | 8496 | 0 | None | -1 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 155817484 | 8496 | 0 | None | -1 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 155817484 | 8496 | 0 | None | -1 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 6117 | 8496 | 0 | None | -1 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 6117 | 8496 | 0 | None | -1 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 6117 | 8496 | 0 | None | -1 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 6117 | 8496 | 0 | None | -1 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 6129 | 8496 | 0 | None | -1 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 6129 | 8496 | 0 | None | -1 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 6129 | 8496 | 0 | None | -1 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 6129 | 8496 | 0 | None | -1 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 101927062 | 8495 | 22 | None | 8 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 101927062 | 8495 | 22 | None | 8 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 155817445 | 8495 | 22 | None | 8 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 155817445 | 8495 | 22 | None | 8 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 16133823 | 8495 | 22 | None | 8 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 16133823 | 8495 | 22 | None | 8 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 3592 | 8495 | 22 | None | 8 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 3592 | 8495 | 22 | None | 8 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 44584852 | 8495 | 22 | None | 8 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 44584852 | 8495 | 22 | None | 8 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 6090 | 8495 | 22 | None | 8 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 6090 | 8495 | 22 | None | 8 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 91898917 | 8495 | 22 | None | 8 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 91898917 | 8495 | 22 | None | 8 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| CHEMBL506553 | 8495 | 22 | None | 8 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| CHEMBL506553 | 8495 | 22 | None | 8 | 6 | Rat | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 16133243 | 8497 | 0 | None | -1 | 8 | Rat | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 16133243 | 8497 | 0 | None | -1 | 8 | Rat | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 9281594 | ||||
| 16133243 | 8497 | 0 | None | -1 | 8 | Rat | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 9405385 | ||||
| 16133243 | 8497 | 0 | None | -1 | 8 | Rat | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 16133243 | 8497 | 0 | None | -1 | 8 | Rat | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 9742938 | ||||
| 3593 | 8497 | 0 | None | -1 | 8 | Rat | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 3593 | 8497 | 0 | None | -1 | 8 | Rat | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 9281594 | ||||
| 3593 | 8497 | 0 | None | -1 | 8 | Rat | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 9405385 | ||||
| 3593 | 8497 | 0 | None | -1 | 8 | Rat | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 3593 | 8497 | 0 | None | -1 | 8 | Rat | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 9742938 | ||||
| 6099 | 9222 | 0 | None | 23 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 11600206 | ||||
| 3898 | 9224 | 0 | None | 1 | 7 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 15944002 | ||||
| 3898 | 9224 | 0 | None | 1 | 7 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| 3898 | 9224 | 0 | None | 1 | 7 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 155817463 | 7564 | 0 | None | 4 | 8 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| 155817463 | 7564 | 0 | None | 4 | 8 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 3861 | 7564 | 0 | None | 4 | 8 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| 3861 | 7564 | 0 | None | 4 | 8 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 6100 | 9227 | 0 | None | 25 | 3 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | None | ||||
| 3897 | 9223 | 0 | None | 2 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | Guide to Pharmacology | None | None | None | None | 11600206 | ||||
| 3897 | 9223 | 0 | None | 2 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 101927062 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 11600206 | ||||
| 101927062 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 101927062 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| 101927062 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 155817445 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 11600206 | ||||
| 155817445 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 155817445 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| 155817445 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 16133823 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 11600206 | ||||
| 16133823 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 16133823 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| 16133823 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 3592 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 11600206 | ||||
| 3592 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 3592 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| 3592 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 44584852 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 11600206 | ||||
| 44584852 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 44584852 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| 44584852 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 6090 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 11600206 | ||||
| 6090 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 6090 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| 6090 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 91898917 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 11600206 | ||||
| 91898917 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 91898917 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| 91898917 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| CHEMBL506553 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 11600206 | ||||
| CHEMBL506553 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| CHEMBL506553 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| CHEMBL506553 | 8495 | 22 | None | -10 | 6 | Human | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 16133243 | 8497 | 0 | None | 1 | 8 | Mouse | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9271210 | ||||
| 16133243 | 8497 | 0 | None | 1 | 8 | Mouse | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9832122 | ||||
| 3593 | 8497 | 0 | None | 1 | 8 | Mouse | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9271210 | ||||
| 3593 | 8497 | 0 | None | 1 | 8 | Mouse | 9.8 | pKi | = | 9.8 | Binding | Guide to Pharmacology | None | None | None | None | 9832122 | ||||
| 3899 | 9225 | 0 | None | 3 | 8 | Mouse | 9.9 | pKi | = | 9.9 | Binding | Guide to Pharmacology | None | None | None | None | 9271210 | ||||
| 3899 | 9225 | 0 | None | 3 | 8 | Mouse | 9.9 | pKi | = | 9.9 | Binding | Guide to Pharmacology | None | None | None | None | 9832122 | ||||
| 3896 | 9221 | 0 | None | 13 | 7 | Human | 10.0 | pKi | = | 10.0 | Binding | Guide to Pharmacology | None | None | None | None | 15944002 | ||||
| 3896 | 9221 | 0 | None | 13 | 7 | Human | 10.0 | pKi | = | 10.0 | Binding | Guide to Pharmacology | None | None | None | None | 9808667 | ||||
| 3896 | 9221 | 0 | None | 13 | 7 | Human | 10.0 | pKi | = | 10.0 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 6127 | 8542 | 0 | None | -575 | 3 | Human | 5.0 | pKi | > | 5 | Binding | Guide to Pharmacology | 397 | 3 | 0 | 4 | 5.2 | COc1ccc(cn1)N1C(=O)/C(=N/c2ccc(c(c2)Cl)Cl)/c2c1cccc2 | 15944007 | ||
| 9800980 | 8542 | 0 | None | -575 | 3 | Human | 5.0 | pKi | > | 5 | Binding | Guide to Pharmacology | 397 | 3 | 0 | 4 | 5.2 | COc1ccc(cn1)N1C(=O)/C(=N/c2ccc(c(c2)Cl)Cl)/c2c1cccc2 | 15944007 | ||
| 155817474 | 8509 | 0 | None | -301 | 5 | Human | 5.3 | pKi | > | 5.3 | Binding | Guide to Pharmacology | None | None | None | None | 15944002 | ||||
| 5357 | 8509 | 0 | None | -301 | 5 | Human | 5.3 | pKi | > | 5.3 | Binding | Guide to Pharmacology | None | None | None | None | 15944002 | ||||
| 155817480 | 8512 | 0 | None | -3 | 6 | Human | 5.5 | pKi | > | 5.5 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 155817480 | 8512 | 0 | None | -3 | 6 | Human | 5.5 | pKi | > | 5.5 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 6091 | 8512 | 0 | None | -3 | 6 | Human | 5.5 | pKi | > | 5.5 | Binding | Guide to Pharmacology | None | None | None | None | 7524088 | ||||
| 6091 | 8512 | 0 | None | -3 | 6 | Human | 5.5 | pKi | > | 5.5 | Binding | Guide to Pharmacology | None | None | None | None | 9880084 | ||||
| 155817482 | 8499 | 0 | None | -2 | 3 | Mouse | 5.8 | pKi | > | 5.8 | Binding | Guide to Pharmacology | None | None | None | None | 9832122 | ||||
| 6093 | 8499 | 0 | None | -2 | 3 | Mouse | 5.8 | pKi | > | 5.8 | Binding | Guide to Pharmacology | None | None | None | None | 9832122 | ||||
| 155817481 | 8513 | 0 | None | -2 | 6 | Mouse | 5.8 | pKi | > | 5.8 | Binding | Guide to Pharmacology | None | None | None | None | 9832122 | ||||
| 6092 | 8513 | 0 | None | -2 | 6 | Mouse | 5.8 | pKi | > | 5.8 | Binding | Guide to Pharmacology | None | None | None | None | 9832122 | ||||
| 155817483 | 8498 | 0 | None | -1 | 2 | Rat | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 6094 | 8498 | 0 | None | -1 | 2 | Rat | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 155817480 | 8512 | 0 | None | -1 | 6 | Rat | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 155817480 | 8512 | 0 | None | -1 | 6 | Rat | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 155817480 | 8512 | 0 | None | -1 | 6 | Rat | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 155817480 | 8512 | 0 | None | -1 | 6 | Rat | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 6091 | 8512 | 0 | None | -1 | 6 | Rat | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | None | None | None | None | 8562318 | ||||
| 6091 | 8512 | 0 | None | -1 | 6 | Rat | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | None | None | None | None | 8750821 | ||||
| 6091 | 8512 | 0 | None | -1 | 6 | Rat | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | None | None | None | None | 9305929 | ||||
| 6091 | 8512 | 0 | None | -1 | 6 | Rat | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | None | None | None | None | 9722565 | ||||
| 155817481 | 8513 | 0 | None | -1 | 6 | Rat | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | None | None | None | None | 9405385 | ||||
| 155817481 | 8513 | 0 | None | -1 | 6 | Rat | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | None | None | None | None | 9742938 | ||||
| 6092 | 8513 | 0 | None | -1 | 6 | Rat | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | None | None | None | None | 9405385 | ||||
| 6092 | 8513 | 0 | None | -1 | 6 | Rat | 6.0 | pKi | > | 6 | Binding | Guide to Pharmacology | None | None | None | None | 9742938 | ||||