GPCRdb

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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

	CCL19	834	None	0	Human	Binding	pKd	=	-	10.00	39	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10512740
	Ccl21b	845	None	0	Human	Binding	pKd	=	-	9.87	-	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10512740
	cenicriviroc	879	None	32	Human	Binding	IC50	=	3.10	8.51	-	6	Inhibition of CCR7 (unknown origin)	ChEMBL	696.4	17	1	7	8.74	CCCCOCCOc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc([S@@](=O)Cc4cncn4CCC)cc2)CCCN3CC(C)C)cc1	https://dx.doi.org/10.1021/acs.jmedchem.9b01701
	CHEMBL5440411	197174	None	1	Human	Binding	IC50	=	1780.00	5.75	-	2	Competitive binding affinity to CCR7 in human U87 cells preincubated for 15 mins followed by CCL19 AF647 addition measured after 30 mins by flow cytometric analysis	ChEMBL	310.2	9	3	7	2.21	CCCCCCSc1nc(N[C@H](C)CO)c2nn[nH]c2n1	https://dx.doi.org/10.1016/j.ejmech.2023.115240
	TAK-779	3742	None	8	Human	Binding	IC50	=	1.40	8.85	-	5	Inhibition of CCR7 (unknown origin)	ChEMBL	495.3	6	1	2	6.78	Cc1ccc(-c2ccc3c(c2)C=C(C(=O)Nc2ccc(C[N+](C)(C)C4CCOCC4)cc2)CCC3)cc1	https://dx.doi.org/10.1021/acs.jmedchem.9b01701

Showing 1 to 5 of 5 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI