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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

5, 6-Dehydroarachidonic acid	218693	3H-LTB4	0	Human	Binding	pKi	=	1000.00	6.00	-1	2	-	PDSP KiDatabase	302.2	12	1	1	5.66	CCCCCC=CCC=CCC=CCC#CCCCC(=O)O	-
CAY10583	812	None	25	Human	Binding	EC50	=	28.90	7.54	-4	2	Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay	ChEMBL	387.2	8	1	2	5.78	CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1	https://dx.doi.org/10.1021/acs.jmedchem.0c00588
CAY10583	812	None	25	Human	Binding	Kd	=	14.74	7.83	-4	2	Displacement of [3H]LTB4 from HA-epitope tagged human BLT2 expressed in CHOK1 cells incubated for 60 mins by liquid scintillation counting method	ChEMBL	387.2	8	1	2	5.78	CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1	https://dx.doi.org/10.1021/acsmedchemlett.0c00065
CAY10583	812	None	25	Mouse	Binding	pKi	=	-	8.52	4	2	Unclassified	Guide to Pharmacology	387.2	8	1	2	5.78	CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1	https://pubmed.ncbi.nlm.nih.gov/15866883
CHEMBL4740860	179579	None	0	Human	Binding	EC50	=	404.00	6.39	-	1	Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay	ChEMBL	415.2	10	1	2	5.81	CCCCN(Cc1ccc(-c2ccccc2C(=O)O)cc1)C(=O)CCc1ccccc1	https://dx.doi.org/10.1021/acs.jmedchem.0c00588
CHEMBL4742371	179717	None	0	Human	Binding	EC50	=	38.30	7.42	-	1	Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay	ChEMBL	421.2	7	1	2	5.83	O=C(O)c1ccccc1-c1ccc(CN(C(=O)Cc2ccccc2)c2ccccc2)cc1	https://dx.doi.org/10.1021/acs.jmedchem.0c00588
CHEMBL4744319	179862	None	0	Human	Binding	EC50	=	357.00	6.45	-	1	Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay	ChEMBL	388.2	8	1	3	5.17	CCCCC(=O)N(Cc1ccc(-c2cnccc2C(=O)O)cc1)c1ccccc1	https://dx.doi.org/10.1021/acs.jmedchem.0c00588
CHEMBL4745083	179938	None	0	Human	Binding	EC50	=	60.70	7.22	-	1	Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay	ChEMBL	405.2	8	1	2	5.91	CCCCC(=O)N(Cc1ccc(-c2ccc(F)cc2C(=O)O)cc1)c1ccccc1	https://dx.doi.org/10.1021/acs.jmedchem.0c00588
CHEMBL4745616	179980	None	0	Human	Binding	EC50	=	570.00	6.24	-	1	Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay	ChEMBL	401.2	8	0	3	5.86	CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)OC)cc1)c1ccccc1	https://dx.doi.org/10.1021/acs.jmedchem.0c00588
CHEMBL4745803	179995	None	0	Human	Binding	EC50	=	398.00	6.40	-	1	Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay	ChEMBL	373.2	6	1	2	5.24	CC(C)C(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1	https://dx.doi.org/10.1021/acs.jmedchem.0c00588
CHEMBL4746093	180023	None	0	Human	Binding	EC50	=	216.00	6.67	-	1	Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay	ChEMBL	387.2	8	1	2	5.49	CCCCN(Cc1ccc(-c2ccccc2C(=O)O)cc1)C(=O)c1ccccc1	https://dx.doi.org/10.1021/acs.jmedchem.0c00588
CHEMBL4746259	180039	None	0	Human	Binding	EC50	=	96.00	7.02	-	1	Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay	ChEMBL	402.2	8	2	2	5.57	CCCCNC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1	https://dx.doi.org/10.1021/acs.jmedchem.0c00588
CHEMBL4746397	180052	None	0	Human	Binding	EC50	=	2650.00	5.58	-	1	Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay	ChEMBL	401.2	9	1	2	5.77	CCCCC(=O)N(Cc1ccccc1)Cc1ccc(-c2ccccc2C(=O)O)cc1	https://dx.doi.org/10.1021/acs.jmedchem.0c00588
CHEMBL4746980	180099	None	0	Human	Binding	EC50	=	720.00	6.14	-	1	Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay	ChEMBL	421.1	8	1	2	6.43	CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1cccc(Cl)c1	https://dx.doi.org/10.1021/acs.jmedchem.0c00588
CHEMBL4748013	180183	None	0	Human	Binding	EC50	=	2400.00	5.62	-	1	Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay	ChEMBL	345.1	5	1	2	4.61	CC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1	https://dx.doi.org/10.1021/acs.jmedchem.0c00588
CHEMBL4748248	180199	None	0	Human	Binding	EC50	=	75.00	7.12	-	1	Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay	ChEMBL	403.2	8	2	3	5.48	CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(O)cc1	https://dx.doi.org/10.1021/acs.jmedchem.0c00588
CHEMBL4748657	180229	None	0	Human	Binding	EC50	=	428.00	6.37	-	1	Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay	ChEMBL	421.1	8	1	2	6.43	CCCCC(=O)N(Cc1ccc(-c2ccc(Cl)cc2C(=O)O)cc1)c1ccccc1	https://dx.doi.org/10.1021/acs.jmedchem.0c00588
CHEMBL4750707	180386	None	0	Human	Binding	EC50	=	229.00	6.64	-	1	Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay	ChEMBL	417.2	9	1	3	5.78	CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(OC)cc1	https://dx.doi.org/10.1021/acs.jmedchem.0c00588
CHEMBL4752602	180553	None	0	Human	Binding	EC50	=	47.50	7.32	-	1	Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay	ChEMBL	421.1	8	1	2	6.43	CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(Cl)cc1	https://dx.doi.org/10.1021/acs.jmedchem.0c00588
CHEMBL4753057	180592	None	0	Human	Binding	EC50	=	42.20	7.38	-	1	Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay	ChEMBL	373.2	7	1	2	5.38	CCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1	https://dx.doi.org/10.1021/acs.jmedchem.0c00588

Showing 1 to 20 of 63 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

12-epi LTB₄	9	None	0	Human	Functional	pEC50	>	-	7.52	-	1	Unclassified	Guide to Pharmacology	336.2	14	3	3	4.16	CCCCC/C=C\C[C@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/11278893
12-hydroxyheptadecatrienoic acid	10	None	0	Human	Functional	pEC50	=	-	7.72	-	1	Unclassified	Guide to Pharmacology	280.2	12	2	2	4.24	CCCCC[C@H](O)/C=C/C=C/C/C=C\CCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/18378794
12-hydroxyheptadecatrienoic acid	10	None	0	Human	Functional	pIC50	=	-	8.55	-	1	Unclassified	Guide to Pharmacology	280.2	12	2	2	4.24	CCCCC[C@H](O)/C=C/C=C/C/C=C\CCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/18378794
12S-HETE	12	None	27	Human	Functional	pEC50	>	-	7.52	-107	3	Unclassified	Guide to Pharmacology	320.2	14	2	2	5.19	CCCCC/C=C\C[C@H](O)/C=C/C=C\C/C=C\CCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/11278893
15S-HETE	23	None	0	Human	Functional	pEC50	>	-	7.52	-	1	Unclassified	Guide to Pharmacology	320.2	14	2	2	5.19	CCCCC[C@H](O)/C=C/C=C\C/C=C\C/C=C\CCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/11278893
candesartan	786	None	65	Human	Functional	EC50	=	15000.00	4.82	-8128	11	Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay	ChEMBL	440.2	7	2	7	4.03	CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	https://dx.doi.org/10.1021/acsmedchemlett.1c00240
CAY10583	812	None	25	Human	Functional	pEC50	=	-	7.70	-	2	Unclassified	Guide to Pharmacology	387.2	8	1	2	5.78	CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1	https://pubmed.ncbi.nlm.nih.gov/15866883
CHEMBL1094348	8535	None	0	Human	Functional	IC50	=	194.00	6.71	-15	2	Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge	ChEMBL	642.3	18	2	6	8.33	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O	https://dx.doi.org/10.1021/jm1001919
CHEMBL1099323	9116	None	0	Human	Functional	IC50	=	628.00	6.20	-223	2	Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge	ChEMBL	580.3	18	2	4	8.46	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O	https://dx.doi.org/10.1021/jm1001919
CHEMBL1099326	9119	None	0	Human	Functional	IC50	=	143.00	6.84	-64	2	Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge	ChEMBL	582.3	18	2	6	7.25	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O	https://dx.doi.org/10.1021/jm1001919
CHEMBL1099330	9123	None	0	Human	Functional	IC50	=	3060.00	5.51	-316	2	Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge	ChEMBL	581.3	18	2	5	7.86	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O	https://dx.doi.org/10.1021/jm1001919
CHEMBL115771	10149	None	0	Human	Functional	EC50	=	6580.00	5.18	-2	3	Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay	ChEMBL	438.2	6	1	3	5.35	O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1	https://dx.doi.org/10.1021/acsmedchemlett.1c00240
CHEMBL116170	10295	None	0	Human	Functional	EC50	=	860.00	6.07	-117	3	Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay	ChEMBL	418.2	7	1	3	5.69	CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1	https://dx.doi.org/10.1021/acsmedchemlett.1c00240
CHEMBL439968	169204	None	0	Human	Functional	EC50	=	1490.00	5.83	-147	3	Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay	ChEMBL	404.2	7	1	3	5.30	CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1	https://dx.doi.org/10.1021/acsmedchemlett.1c00240
CHEMBL444060	169990	None	0	Human	Functional	EC50	=	24200.00	4.62	-7	3	Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay	ChEMBL	406.2	7	2	3	4.81	CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1	https://dx.doi.org/10.1021/acsmedchemlett.1c00240
CHEMBL4854916	185124	None	0	Human	Functional	EC50	=	7500.00	5.12	1	2	Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay	ChEMBL	416.2	7	1	5	3.86	CCCC[C@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@H]2CCCN21	https://dx.doi.org/10.1021/acsmedchemlett.1c00240
CHEMBL4856425	185232	None	0	Human	Functional	EC50	=	550.00	6.26	-21	2	Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay	ChEMBL	464.2	8	1	5	5.38	CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1	https://dx.doi.org/10.1021/acsmedchemlett.1c00240
CHEMBL4859498	185422	None	0	Human	Functional	EC50	=	6390.00	5.19	-16	2	Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay	ChEMBL	404.2	7	2	5	3.76	CCCCC1NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1	https://dx.doi.org/10.1021/acsmedchemlett.1c00240
CHEMBL4872989	186308	None	0	Human	Functional	EC50	=	67.60	7.17	-4	2	Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay	ChEMBL	430.2	8	1	5	4.88	CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1	https://dx.doi.org/10.1021/acsmedchemlett.1c00240
CHEMBL4877651	186629	None	4	Human	Functional	EC50	=	8140.00	5.09	-257	2	Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay	ChEMBL	402.2	7	1	5	4.24	CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1	https://dx.doi.org/10.1021/acsmedchemlett.1c00240

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Ligand source activities (1 row/activity)