GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	11344	764	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	β-arrestin recruitment determined in a BRET assayβ-arrestin recruitment determined in a BRET assay	Guide to Pharmacology		None	None	None		None	31036565
	574	762	0	None	69	2	Human	8.6	pEC50	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	None
	573	759	0	None	-1	2	Human	8.9	pEC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11773063
	5768	763	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12899627
	5770	901	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	17258808
	574	762	0	None	69	2	Human	7.7	pIC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11773063
	574	762	0	None	69	2	Human	7.7	pIC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12899627
	573	759	0	None	-1	2	Human	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11773063
	573	759	0	None	-1	2	Human	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12899627
	5780	211	0	None	-37	2	Mouse	6.0	pIC50	~	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	14570896

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	155541442	172451	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Partial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assayPartial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assay	ChEMBL	1119	29	17	13	-0.9	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	nan
	CHEMBL4518532	172451	0	None	-	0	Human	5.2	pEC50	=	5.2	Binding	Partial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assayPartial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assay	ChEMBL	1119	29	17	13	-0.9	CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	nan
	155555017	173739	0	None	-	1	Human	5.1	pEC50	=	5.1	Binding	Partial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assayPartial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assay	ChEMBL	898	28	14	9	0.4	CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	nan
	CHEMBL4550325	173739	0	None	-	1	Human	5.1	pEC50	=	5.1	Binding	Partial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assayPartial agonist activity at C5a2 receptor (unknown origin) expressed in HEK293 cells assessed as induction of beta-arrestin-2 recruitment incubated for 1 hr by BRET assay	ChEMBL	898	28	14	9	0.4	CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	nan
	155555017	173739	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]-C5a from C5a2 receptor (unknown origin) expressed in Flp-In CHO cell membranes incubated for 1 hr by microbeta scintillation counting assayDisplacement of [125I]-C5a from C5a2 receptor (unknown origin) expressed in Flp-In CHO cell membranes incubated for 1 hr by microbeta scintillation counting assay	ChEMBL	898	28	14	9	0.4	CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	nan
	CHEMBL4550325	173739	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [125I]-C5a from C5a2 receptor (unknown origin) expressed in Flp-In CHO cell membranes incubated for 1 hr by microbeta scintillation counting assayDisplacement of [125I]-C5a from C5a2 receptor (unknown origin) expressed in Flp-In CHO cell membranes incubated for 1 hr by microbeta scintillation counting assay	ChEMBL	898	28	14	9	0.4	CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	nan
	9384	2938	0	None	-	1	Human	3.7	pKi	=	3.7	Binding	Binding assayBinding assay	Guide to Pharmacology		None	None	None		None	27108698
	9385	2940	0	None	-	1	Human	4.2	pKi	=	4.2	Binding	Binding assayBinding assay	Guide to Pharmacology		None	None	None		None	27108698