Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
44378315 64239 11 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 332 14 0 3 5.5 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)OC 10.1016/j.bmc.2018.05.036
CHEMBL165682 64239 11 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 332 14 0 3 5.5 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)OC 10.1016/j.bmc.2018.05.036
145962053 168412 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 330 13 0 3 5.3 CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)OC 10.1016/j.bmc.2018.05.036
CHEMBL4130040 168412 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 330 13 0 3 5.3 CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)OC 10.1016/j.bmc.2018.05.036
3391 6943 21 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmc.2018.05.036
3416 6943 21 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmc.2018.05.036
5283159 6943 21 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmc.2018.05.036
CHEMBL18028 6943 21 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmc.2018.05.036
102164179 168214 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 316 13 1 2 5.2 CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmc.2018.05.036
CHEMBL4127146 168214 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay
ChEMBL 316 13 1 2 5.2 CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmc.2018.05.036
6167 6940 8 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 10.1016/j.bmcl.2011.01.032
6438757 6940 8 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 10.1016/j.bmcl.2011.01.032
CHEMBL1682258 6940 8 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 10.1016/j.bmcl.2011.01.032
3391 6943 21 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assayAgonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1039/C1MD00231G
3416 6943 21 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assayAgonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1039/C1MD00231G
5283159 6943 21 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assayAgonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1039/C1MD00231G
CHEMBL18028 6943 21 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assayAgonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assay
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1039/C1MD00231G
3391 6943 21 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.01.032
3416 6943 21 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.01.032
5283159 6943 21 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.01.032
CHEMBL18028 6943 21 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.01.032
122588275 173537 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 453 12 1 3 6.9 C[C@H](CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4283608 173537 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 453 12 1 3 6.9 C[C@H](CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
122588230 173772 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 453 12 1 3 6.9 CC(CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4287941 173772 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 453 12 1 3 6.9 CC(CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
145980814 173417 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@H](CC(=O)O)CC(=O)c1c([C@@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4281149 173417 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@H](CC(=O)O)CC(=O)c1c([C@@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
122588209 173593 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 439 11 1 3 6.5 CC(CC(=O)O)CC(=O)c1c(CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4284672 173593 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 439 11 1 3 6.5 CC(CC(=O)O)CC(=O)c1c(CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
49800286 112082 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 9 1 3 5.3 CCCCCCc1cc2ccccc2n1C(=O)CC(C)(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115781 112082 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 9 1 3 5.3 CCCCCCc1cc2ccccc2n1C(=O)CC(C)(C)CC(=O)O 10.1021/jm401292m
49802318 163481 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 397 8 1 3 5.9 CCCCCCc1c(C(=O)c2cccc(C(=O)O)c2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4070005 163481 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 397 8 1 3 5.9 CCCCCCc1c(C(=O)c2cccc(C(=O)O)c2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49804576 94114 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL2332567 94114 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
71717596 94112 1 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 265 4 1 3 3.2 O=C(O)CCCC(=O)n1ccc2cc(Cl)ccc21 10.1021/jm400480j
CHEMBL2332561 94112 1 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 265 4 1 3 3.2 O=C(O)CCCC(=O)n1ccc2cc(Cl)ccc21 10.1021/jm400480j
49800562 94111 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cccc2ccn(C(=O)CCCC(=O)O)c12 10.1021/jm400480j
CHEMBL2332560 94111 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cccc2ccn(C(=O)CCCC(=O)O)c12 10.1021/jm400480j
145984927 173206 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 439 11 1 3 6.8 CC(CC(=O)O)CC(=O)n1c(CCCCCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
CHEMBL4277299 173206 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 439 11 1 3 6.8 CC(CC(=O)O)CC(=O)n1c(CCCCCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
145984923 173201 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@@H](CC(=O)O)CC(=O)c1c([C@@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4277207 173201 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@@H](CC(=O)O)CC(=O)c1c([C@@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
137638047 163556 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 391 10 1 3 6.0 CCCCCCc1c(C(=O)CC(C)(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4070795 163556 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 391 10 1 3 6.0 CCCCCCc1c(C(=O)CC(C)(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
76336045 112084 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 9 1 3 5.2 CCCCCCc1c(C)c2ccccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115783 112084 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 9 1 3 5.2 CCCCCCc1c(C)c2ccccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
137644937 165267 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 397 8 1 3 5.9 CCCCCCc1c(C(=O)c2ccc(C(=O)O)cc2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4090987 165267 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 397 8 1 3 5.9 CCCCCCc1c(C(=O)c2ccc(C(=O)O)cc2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49800561 112095 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 287 7 1 3 3.9 CCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115794 112095 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 287 7 1 3 3.9 CCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
66644017 112086 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2cc(Cl)ccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115785 112086 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2cc(Cl)ccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
49804576 94114 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm400480j
CHEMBL2332567 94114 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm400480j
66644128 112078 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL3115775 112078 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49800843 112081 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 341 9 1 3 5.0 CCCCCCc1cc2ccccc2n1C(=O)CC1(CC(=O)O)CC1 10.1021/jm401292m
CHEMBL3115780 112081 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 341 9 1 3 5.0 CCCCCCc1cc2ccccc2n1C(=O)CC1(CC(=O)O)CC1 10.1021/jm401292m
49802029 112077 5 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/acs.jmedchem.8b00154
CHEMBL3115774 112077 5 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/acs.jmedchem.8b00154
66644128 112078 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/acs.jmedchem.8b00154
CHEMBL3115775 112078 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/acs.jmedchem.8b00154
49800564 94109 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1ccc2c(ccn2C(=O)CCCC(=O)O)c1 10.1021/jm400480j
CHEMBL2332558 94109 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1ccc2c(ccn2C(=O)CCCC(=O)O)c1 10.1021/jm400480j
49802029 112077 5 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometryAntagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1016/j.bmcl.2014.05.090
CHEMBL3115774 112077 5 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometryAntagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1016/j.bmcl.2014.05.090
145986668 173967 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 411 9 1 3 6.0 CC(CC(=O)O)CC(=O)n1c(CCCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
CHEMBL4291346 173967 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 411 9 1 3 6.0 CC(CC(=O)O)CC(=O)n1c(CCCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
49800839 94110 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1ccc2ccn(C(=O)CCCC(=O)O)c2c1 10.1021/jm400480j
CHEMBL2332559 94110 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1ccc2ccn(C(=O)CCCC(=O)O)c2c1 10.1021/jm400480j
118707104 119789 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometryAntagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry
ChEMBL 361 8 1 3 5.6 CCCC/C=C/c1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1016/j.bmcl.2014.05.090
CHEMBL3311229 119789 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometryAntagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry
ChEMBL 361 8 1 3 5.6 CCCC/C=C/c1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1016/j.bmcl.2014.05.090
145979967 173472 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 425 10 1 3 6.4 CC(CC(=O)O)CC(=O)n1c(CCCCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
CHEMBL4282356 173472 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 425 10 1 3 6.4 CC(CC(=O)O)CC(=O)n1c(CCCCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
49802316 121673 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)C[C@H](C)CC(=O)O 10.1021/ml500161v
CHEMBL3341973 121673 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)C[C@H](C)CC(=O)O 10.1021/ml500161v
49802026 121671 2 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/ml500161v
CHEMBL3341971 121671 2 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/ml500161v
1051 8237 63 None 14 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O 10.1021/jm401292m
4289 8237 63 None 14 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O 10.1021/jm401292m
445580 8237 63 None 14 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O 10.1021/jm401292m
57417355 8237 63 None 14 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O 10.1021/jm401292m
CHEMBL367149 8237 63 None 14 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O 10.1021/jm401292m
DB03756 8237 63 None 14 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O 10.1021/jm401292m
3174 8351 67 None 234 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1021/jm401292m
3362 8351 67 None 234 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1021/jm401292m
446284 8351 67 None 234 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1021/jm401292m
CHEMBL460026 8351 67 None 234 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1021/jm401292m
DB00159 8351 67 None 234 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O 10.1021/jm401292m
5312529 180669 31 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 306 15 1 1 6.4 CC/C=C\C/C=C\C/C=C\CCCCCCCCCC(=O)O 10.1021/jm401292m
CHEMBL453991 180669 31 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 306 15 1 1 6.4 CC/C=C\C/C=C\C/C=C\CCCCCCCCCC(=O)O 10.1021/jm401292m
5280581 185135 44 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 306 15 1 1 6.4 CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(=O)O 10.1021/jm401292m
CHEMBL465183 185135 44 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
ChEMBL 306 15 1 1 6.4 CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(=O)O 10.1021/jm401292m
49804582 94108 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cn(C(=O)CCCC(=O)O)c2ccccc12 10.1021/jm400480j
CHEMBL2332557 94108 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 315 9 1 3 4.7 CCCCCCc1cn(C(=O)CCCC(=O)O)c2ccccc12 10.1021/jm400480j
145979016 173395 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 397 8 1 3 5.6 CC(CC(=O)O)CC(=O)n1c(CCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
CHEMBL4280693 173395 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 397 8 1 3 5.6 CC(CC(=O)O)CC(=O)n1c(CCCc2ccccc2)cc2ccc(Cl)cc21 10.1021/acs.jmedchem.8b00154
49800284 112096 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 301 8 1 3 4.3 CCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115795 112096 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 301 8 1 3 4.3 CCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
49802029 112077 5 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115774 112077 5 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
122588268 173749 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 411 9 1 3 5.7 CC(CC(=O)O)CC(=O)c1c(CCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4287509 173749 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 411 9 1 3 5.7 CC(CC(=O)O)CC(=O)c1c(CCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
137647550 164753 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 447 15 1 3 7.6 CCCCCCCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4084871 164753 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 447 15 1 3 7.6 CCCCCCCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
122600362 173976 3 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 453 12 1 3 6.9 C[C@@H](CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4291464 173976 3 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 453 12 1 3 6.9 C[C@@H](CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
10544716 112079 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysisAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysis
ChEMBL 334 14 2 3 4.4 CCCCC/C=C\C[C@H](O)/C=C/C=C/C=C/C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115777 112079 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysisAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysis
ChEMBL 334 14 2 3 4.4 CCCCC/C=C\C[C@H](O)/C=C/C=C/C=C/C(=O)CCCC(=O)O 10.1021/jm401292m
76317856 112094 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 421 10 1 3 5.7 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Br)ccc2n1C 10.1021/jm401292m
CHEMBL3115793 112094 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 421 10 1 3 5.7 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Br)ccc2n1C 10.1021/jm401292m
145993055 173617 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@H](CC(=O)O)CC(=O)c1c([C@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4285167 173617 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@H](CC(=O)O)CC(=O)c1c([C@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
66644128 112078 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
CHEMBL3115775 112078 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
49802029 112077 5 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115774 112077 5 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
66644128 112078 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
CHEMBL3115775 112078 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
3391 6943 21 None - 1 Human 8.5 pIC50 = 8.5 Functional
Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationDesensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.02.021
3416 6943 21 None - 1 Human 8.5 pIC50 = 8.5 Functional
Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationDesensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.02.021
5283159 6943 21 None - 1 Human 8.5 pIC50 = 8.5 Functional
Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationDesensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.02.021
CHEMBL18028 6943 21 None - 1 Human 8.5 pIC50 = 8.5 Functional
Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationDesensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization
ChEMBL 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 10.1016/j.bmcl.2011.02.021
76328737 112087 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 407 9 1 3 5.7 CCCCCCc1cc2ccc(Br)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115786 112087 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 407 9 1 3 5.7 CCCCCCc1cc2ccc(Br)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
49804581 112092 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 10 1 3 5.0 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2ccccc2n1C 10.1021/jm401292m
CHEMBL3115791 112092 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 10 1 3 5.0 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2ccccc2n1C 10.1021/jm401292m
76332419 112088 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 359 10 1 4 4.9 CCCCCCc1cc2ccc(OC)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115787 112088 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 359 10 1 4 4.9 CCCCCCc1cc2ccc(OC)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
145982307 173290 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 431 10 1 3 6.2 CC(CC(=O)O)CC(=O)c1c(CCCCCC(F)(F)F)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4278772 173290 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 431 10 1 3 6.2 CC(CC(=O)O)CC(=O)c1c(CCCCCC(F)(F)F)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
122600340 173335 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 425 10 1 3 6.1 CC(CC(=O)O)CC(=O)c1c(CCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4279605 173335 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 425 10 1 3 6.1 CC(CC(=O)O)CC(=O)c1c(CCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
71720638 94113 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 265 4 1 3 3.2 O=C(O)CCCC(=O)n1ccc2ccc(Cl)cc21 10.1021/jm400480j
CHEMBL2332562 94113 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis
ChEMBL 265 4 1 3 3.2 O=C(O)CCCC(=O)n1ccc2ccc(Cl)cc21 10.1021/jm400480j
66644266 112097 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 313 8 1 3 4.7 CCCC/C=C/c1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115796 112097 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 313 8 1 3 4.7 CCCC/C=C/c1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
137660364 165832 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 391 10 1 3 6.0 CCCCCCc1c(C(=O)CCC(C)(C)C(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4096962 165832 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 391 10 1 3 6.0 CCCCCCc1c(C(=O)CCC(C)(C)C(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
118707105 119790 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometryAntagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry
ChEMBL 361 8 1 3 5.6 CCCC/C=C\c1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1016/j.bmcl.2014.05.090
CHEMBL3311230 119790 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometryAntagonist activity at 5-oxo-ETE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition by indo-1 staining-based spectrofluorometry
ChEMBL 361 8 1 3 5.6 CCCC/C=C\c1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1016/j.bmcl.2014.05.090
10568747 6939 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysisAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysis
ChEMBL 334 14 2 3 4.4 CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O 10.1021/jm401292m
6171 6939 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysisAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysis
ChEMBL 334 14 2 3 4.4 CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O 10.1021/jm401292m
CHEMBL3115778 6939 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysisAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric analysis
ChEMBL 334 14 2 3 4.4 CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O 10.1021/jm401292m
3404 6801 29 None -1778 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assay
ChEMBL 320 14 2 2 5.2 CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 10.1021/acs.jmedchem.8b00154
5283155 6801 29 None -1778 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assay
ChEMBL 320 14 2 2 5.2 CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 10.1021/acs.jmedchem.8b00154
5508 6801 29 None -1778 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assay
ChEMBL 320 14 2 2 5.2 CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 10.1021/acs.jmedchem.8b00154
CHEMBL1526258 6801 29 None -1778 3 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition by fluorescence assay
ChEMBL 320 14 2 2 5.2 CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 10.1021/acs.jmedchem.8b00154
68036050 112101 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 383 13 1 3 6.7 CCCCCCCCC/C=C\c1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115800 112101 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 383 13 1 3 6.7 CCCCCCCCC/C=C\c1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
137655720 165762 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 365 10 1 4 4.2 CCCCCCc1c(C(=O)COCC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4096265 165762 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 365 10 1 4 4.2 CCCCCCc1c(C(=O)COCC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49801419 112091 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 10 1 3 5.4 CCCCCCc1c(C(=O)CCCC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
CHEMBL3115790 112091 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 10 1 3 5.4 CCCCCCc1c(C(=O)CCCC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
49800560 112099 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 11 1 3 5.4 CCCCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115798 112099 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 343 11 1 3 5.4 CCCCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
137645745 164426 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 389 10 1 3 5.8 CCCCCCc1c(C(=O)CC2(CC(=O)O)CC2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4081391 164426 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 389 10 1 3 5.8 CCCCCCc1c(C(=O)CC2(CC(=O)O)CC2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
66644128 112078 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
CHEMBL3115775 112078 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
49778909 121672 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49778909 121672 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/acs.jmedchem.8b00154
CHEMBL3341972 121672 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL3341972 121672 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/acs.jmedchem.8b00154
49778909 121672 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/ml500161v
CHEMBL3341972 121672 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)C[C@H](C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/ml500161v
49804580 112090 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 329 10 1 3 4.7 CCCCCCc1c(C(=O)CCCC(=O)O)c2ccccc2n1C 10.1021/jm401292m
CHEMBL3115789 112090 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 329 10 1 3 4.7 CCCCCCc1c(C(=O)CCCC(=O)O)c2ccccc2n1C 10.1021/jm401292m
76336046 112085 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 407 9 1 3 5.7 CCCCCCc1cc2cc(Br)ccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115784 112085 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 407 9 1 3 5.7 CCCCCCc1cc2cc(Br)ccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
49802029 112077 5 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115774 112077 5 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
49802029 112077 5 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/ml500161v
CHEMBL3115774 112077 5 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of calcium mobilization by fluorescence assay
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/ml500161v
53248990 67454 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationDesensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization
ChEMBL 372 14 1 2 5.9 O=C(O)CCCC(=O)/C=C/C=C\C/C=C\C/C=C\CCCCC(F)(F)F 10.1016/j.bmcl.2011.02.021
CHEMBL1760545 67454 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Desensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilizationDesensitization of 5-oxo-ETE receptor in indo-1-labeled human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization
ChEMBL 372 14 1 2 5.9 O=C(O)CCCC(=O)/C=C/C=C\C/C=C\C/C=C\CCCCC(F)(F)F 10.1016/j.bmcl.2011.02.021
49800558 112100 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 385 14 1 3 6.6 CCCCCCCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115799 112100 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 385 14 1 3 6.6 CCCCCCCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
137655326 165340 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 403 10 1 3 6.2 CCCCCCc1c(C(=O)CC2(CC(=O)O)CCC2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4091674 165340 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 403 10 1 3 6.2 CCCCCCc1c(C(=O)CC2(CC(=O)O)CCC2)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49800841 112098 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 329 10 1 3 5.0 CCCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115797 112098 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 329 10 1 3 5.0 CCCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O 10.1021/jm401292m
145989845 174016 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@@H](CC(=O)O)CC(=O)c1c([C@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
CHEMBL4292357 174016 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 469 12 2 4 6.4 C[C@@H](CC(=O)O)CC(=O)c1c([C@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 10.1021/acs.jmedchem.8b00154
49802589 112093 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2ccc(Cl)cc2n1C 10.1021/jm401292m
CHEMBL3115792 112093 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2ccc(Cl)cc2n1C 10.1021/jm401292m
137638887 163464 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 391 10 1 3 6.0 CCCCCCc1c(C(=O)C(C)(C)CCC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
CHEMBL4069768 163464 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay
ChEMBL 391 10 1 3 6.0 CCCCCCc1c(C(=O)C(C)(C)CCC(=O)O)c2cc(Cl)ccc2n1C 10.1016/j.bmcl.2017.08.034
49804577 112083 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 329 9 1 3 4.9 CCCCCCc1cc2ccccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115782 112083 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 329 9 1 3 4.9 CCCCCCc1cc2ccccc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
66644000 112089 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 315 10 2 2 4.7 CCCCCCc1[nH]c2ccccc2c1C(=O)CCCC(=O)O 10.1021/jm401292m
CHEMBL3115788 112089 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis
ChEMBL 315 10 2 2 4.7 CCCCCCc1[nH]c2ccccc2c1C(=O)CCCC(=O)O 10.1021/jm401292m
6169 6941 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 15 2 3 4.4 OCCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 8598482
73755178 6941 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 15 2 3 4.4 OCCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 8598482
3390 6946 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 16039985
3390 6946 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 7803484
3390 6946 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 8387490
5280733 6946 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 16039985
5280733 6946 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 7803484
5280733 6946 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 8387490
CHEMBL164813 6946 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 16039985
CHEMBL164813 6946 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 7803484
CHEMBL164813 6946 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O 8387490
2483 6947 0 None - 1 Human 7.0 pEC50 = 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 15 2 3 5.7 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)OO 16039985
5280778 6947 0 None - 1 Human 7.0 pEC50 = 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 15 2 3 5.7 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)OO 16039985
CHEMBL1743204 6947 0 None - 1 Human 7.0 pEC50 = 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 15 2 3 5.7 CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)OO 16039985
6167 6940 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 7797484
6167 6940 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 7803484
6167 6940 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 8387490
6167 6940 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 8598482
6438757 6940 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 7797484
6438757 6940 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 7803484
6438757 6940 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 8387490
6438757 6940 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 8598482
CHEMBL1682258 6940 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 7797484
CHEMBL1682258 6940 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 7803484
CHEMBL1682258 6940 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 8387490
CHEMBL1682258 6940 8 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O 8598482
3392 6942 0 None - 1 Human 8.0 pEC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 15 1 2 5.6 CCCCCCCC/C=C\C/C=C\C=C/C(=O)CCCC(=O)O 18292294
56947094 6942 0 None - 1 Human 8.0 pEC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 15 1 2 5.6 CCCCCCCC/C=C\C/C=C\C=C/C(=O)CCCC(=O)O 18292294
6164 6944 0 None - 1 Human 8.0 pEC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 294 14 1 2 5.1 CCCCCCCCC/C=C\C=C\C(=O)CCCC(=O)O 18287092
71751402 6944 0 None - 1 Human 8.0 pEC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 294 14 1 2 5.1 CCCCCCCCC/C=C\C=C\C(=O)CCCC(=O)O 18287092
3391 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 1326548
3391 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 18292294
3391 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 19450703
3391 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 7797484
3391 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
3416 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 1326548
3416 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 18292294
3416 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 19450703
3416 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 7797484
3416 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
5283159 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 1326548
5283159 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 18292294
5283159 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 19450703
5283159 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 7797484
5283159 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
CHEMBL18028 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 1326548
CHEMBL18028 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 18292294
CHEMBL18028 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 19450703
CHEMBL18028 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 7797484
CHEMBL18028 6943 21 None - 1 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
11073 8866 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Inhibition of 5‐oxo‐ETE‐induced calcium mobilization in human neutrophils.Inhibition of 5‐oxo‐ETE‐induced calcium mobilization in human neutrophils.
Guide to Pharmacology 487 12 1 3 7.5 C[C@@H](CC(=O)c1c(CCCCCCc2cccc(c2)Cl)n(c2c1cc(Cl)cc2)C)CC(=O)O 31655025
122588231 8866 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Inhibition of 5‐oxo‐ETE‐induced calcium mobilization in human neutrophils.Inhibition of 5‐oxo‐ETE‐induced calcium mobilization in human neutrophils.
Guide to Pharmacology 487 12 1 3 7.5 C[C@@H](CC(=O)c1c(CCCCCCc2cccc(c2)Cl)n(c2c1cc(Cl)cc2)C)CC(=O)O 31655025
10568747 6939 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O 9920859
6171 6939 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O 9920859
CHEMBL3115778 6939 1 None - 1 Human 6.3 pIC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 334 14 2 3 4.4 CCCCC/C=C\C[C@@H](/C=C/C=C\C=C\C(=O)CCCC(=O)O)O 9920859
6174 6915 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 349 9 1 3 5.3 CCCCCCc1cc2c(n1C(=O)CCCC(=O)O)cc(cc2)Cl 23581530
71655222 6915 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 349 9 1 3 5.3 CCCCCCc1cc2c(n1C(=O)CCCC(=O)O)cc(cc2)Cl 23581530
5066134 8673 0 None - 1 Human 6.0 pIC50 ~ 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 447 5 1 6 6.4 CSc1nc2c(s1)c1sc(nc1cc2)NC(=O)C(c1ccccc1)c1ccccc1 22634634
6173 8673 0 None - 1 Human 6.0 pIC50 ~ 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 447 5 1 6 6.4 CSc1nc2c(s1)c1sc(nc1cc2)NC(=O)C(c1ccccc1)c1ccccc1 22634634
CHEMBL4303495 8673 0 None - 1 Human 6.0 pIC50 ~ 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 447 5 1 6 6.4 CSc1nc2c(s1)c1sc(nc1cc2)NC(=O)C(c1ccccc1)c1ccccc1 22634634


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
49802029 112077 5 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115774 112077 5 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
66644128 112078 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
CHEMBL3115775 112078 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
49802029 112077 5 None - 0 Human 6.4 pIC50 = 6.4 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysisAntagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
CHEMBL3115774 112077 5 None - 0 Human 6.4 pIC50 = 6.4 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysisAntagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysis
ChEMBL 363 9 1 3 5.6 CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O 10.1021/jm401292m
66644128 112078 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysisAntagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
CHEMBL3115775 112078 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysisAntagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysis
ChEMBL 377 10 1 3 5.6 CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C 10.1021/jm401292m
1051 8237 63 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O None
4289 8237 63 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O None
445580 8237 63 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O None
57417355 8237 63 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O None
CHEMBL367149 8237 63 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O None
DB03756 8237 63 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 328 14 1 1 6.5 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O None
3174 8351 67 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O None
3362 8351 67 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O None
446284 8351 67 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O None
CHEMBL460026 8351 67 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O None
DB00159 8351 67 None - 0 Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis
Drug Central 302 13 1 1 6.0 CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O None
3391 6943 21 None - 1 Human 8.4 pKd = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
3416 6943 21 None - 1 Human 8.4 pKd = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
5283159 6943 21 None - 1 Human 8.4 pKd = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988
CHEMBL18028 6943 21 None - 1 Human 8.4 pKd = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 318 14 1 2 5.4 CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O 9829988