Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 44378315 | 57482 | None | 11 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay |
ChEMBL | 332 | 14 | 0 | 3 | 5.5 | CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)OC | 10.1016/j.bmc.2018.05.036 | ||
| CHEMBL165682 | 57482 | None | 11 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay |
ChEMBL | 332 | 14 | 0 | 3 | 5.5 | CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)OC | 10.1016/j.bmc.2018.05.036 | ||
| 145962053 | 161727 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay |
ChEMBL | 330 | 13 | 0 | 3 | 5.3 | CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)OC | 10.1016/j.bmc.2018.05.036 | ||
| CHEMBL4130040 | 161727 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay |
ChEMBL | 330 | 13 | 0 | 3 | 5.3 | CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)OC | 10.1016/j.bmc.2018.05.036 | ||
| 3391 | 155 | None | 17 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay |
ChEMBL | 318 | 14 | 1 | 2 | 5.4 | CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O | 10.1016/j.bmc.2018.05.036 | ||
| 3416 | 155 | None | 17 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay |
ChEMBL | 318 | 14 | 1 | 2 | 5.4 | CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O | 10.1016/j.bmc.2018.05.036 | ||
| 5283159 | 155 | None | 17 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay |
ChEMBL | 318 | 14 | 1 | 2 | 5.4 | CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O | 10.1016/j.bmc.2018.05.036 | ||
| CHEMBL18028 | 155 | None | 17 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay |
ChEMBL | 318 | 14 | 1 | 2 | 5.4 | CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O | 10.1016/j.bmc.2018.05.036 | ||
| 102164179 | 161529 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay |
ChEMBL | 316 | 13 | 1 | 2 | 5.2 | CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O | 10.1016/j.bmc.2018.05.036 | ||
| CHEMBL4127146 | 161529 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | Agonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assayAgonist activity at human PK-tagged OXER1 expressed in CHOK1 cells assessed as EA-tagged beta-arrestin recruitment by beta-galactosidase enzyme fragment complementation assay |
ChEMBL | 316 | 13 | 1 | 2 | 5.2 | CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O | 10.1016/j.bmc.2018.05.036 | ||
| 6167 | 152 | None | 5 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization |
ChEMBL | 334 | 14 | 2 | 3 | 4.4 | CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O | 10.1016/j.bmcl.2011.01.032 | ||
| 6438757 | 152 | None | 5 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization |
ChEMBL | 334 | 14 | 2 | 3 | 4.4 | CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O | 10.1016/j.bmcl.2011.01.032 | ||
| CHEMBL1682258 | 152 | None | 5 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization |
ChEMBL | 334 | 14 | 2 | 3 | 4.4 | CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O)O | 10.1016/j.bmcl.2011.01.032 | ||
| 3391 | 155 | None | 17 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | Agonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assayAgonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assay |
ChEMBL | 318 | 14 | 1 | 2 | 5.4 | CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O | 10.1039/C1MD00231G | ||
| 3416 | 155 | None | 17 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | Agonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assayAgonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assay |
ChEMBL | 318 | 14 | 1 | 2 | 5.4 | CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O | 10.1039/C1MD00231G | ||
| 5283159 | 155 | None | 17 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | Agonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assayAgonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assay |
ChEMBL | 318 | 14 | 1 | 2 | 5.4 | CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O | 10.1039/C1MD00231G | ||
| CHEMBL18028 | 155 | None | 17 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | Agonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assayAgonist activity at OXE receptor (unknown origin) expressed in HEK293 cells co-expressing Galpha subunit G16 assessed as calcium mobilization using Oregon Green 488 BAPTA-1/AM by fluorescence assay |
ChEMBL | 318 | 14 | 1 | 2 | 5.4 | CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O | 10.1039/C1MD00231G | ||
| 3391 | 155 | None | 17 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization |
ChEMBL | 318 | 14 | 1 | 2 | 5.4 | CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O | 10.1016/j.bmcl.2011.01.032 | ||
| 3416 | 155 | None | 17 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization |
ChEMBL | 318 | 14 | 1 | 2 | 5.4 | CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O | 10.1016/j.bmcl.2011.01.032 | ||
| 5283159 | 155 | None | 17 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization |
ChEMBL | 318 | 14 | 1 | 2 | 5.4 | CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O | 10.1016/j.bmcl.2011.01.032 | ||
| CHEMBL18028 | 155 | None | 17 | Human | Functional | pEC50 | = | 8.2 | 8.2 | - | 1 | Agonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilizationAgonist activity at 5-oxo-ETE receptor in human neutrophils assessed as stimulation of ca2+ mobilization |
ChEMBL | 318 | 14 | 1 | 2 | 5.4 | CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O | 10.1016/j.bmcl.2011.01.032 | ||
| 122588275 | 166854 | None | 0 | Human | Functional | pIC50 | = | 9.9 | 9.9 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay |
ChEMBL | 453 | 12 | 1 | 3 | 6.9 | C[C@H](CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 | 10.1021/acs.jmedchem.8b00154 | ||
| CHEMBL4283608 | 166854 | None | 0 | Human | Functional | pIC50 | = | 9.9 | 9.9 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay |
ChEMBL | 453 | 12 | 1 | 3 | 6.9 | C[C@H](CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 | 10.1021/acs.jmedchem.8b00154 | ||
| 122588230 | 167089 | None | 0 | Human | Functional | pIC50 | = | 9.6 | 9.6 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay |
ChEMBL | 453 | 12 | 1 | 3 | 6.9 | CC(CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 | 10.1021/acs.jmedchem.8b00154 | ||
| CHEMBL4287941 | 167089 | None | 0 | Human | Functional | pIC50 | = | 9.6 | 9.6 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay |
ChEMBL | 453 | 12 | 1 | 3 | 6.9 | CC(CC(=O)O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 | 10.1021/acs.jmedchem.8b00154 | ||
| 145980814 | 166733 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay |
ChEMBL | 469 | 12 | 2 | 4 | 6.4 | C[C@H](CC(=O)O)CC(=O)c1c([C@@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 | 10.1021/acs.jmedchem.8b00154 | ||
| CHEMBL4281149 | 166733 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay |
ChEMBL | 469 | 12 | 2 | 4 | 6.4 | C[C@H](CC(=O)O)CC(=O)c1c([C@@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 | 10.1021/acs.jmedchem.8b00154 | ||
| 122588209 | 166910 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay |
ChEMBL | 439 | 11 | 1 | 3 | 6.5 | CC(CC(=O)O)CC(=O)c1c(CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 | 10.1021/acs.jmedchem.8b00154 | ||
| CHEMBL4284672 | 166910 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay |
ChEMBL | 439 | 11 | 1 | 3 | 6.5 | CC(CC(=O)O)CC(=O)c1c(CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 | 10.1021/acs.jmedchem.8b00154 | ||
| 49800286 | 105361 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis |
ChEMBL | 343 | 9 | 1 | 3 | 5.3 | CCCCCCc1cc2ccccc2n1C(=O)CC(C)(C)CC(=O)O | 10.1021/jm401292m | ||
| CHEMBL3115781 | 105361 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis |
ChEMBL | 343 | 9 | 1 | 3 | 5.3 | CCCCCCc1cc2ccccc2n1C(=O)CC(C)(C)CC(=O)O | 10.1021/jm401292m | ||
| 49802318 | 156794 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay |
ChEMBL | 397 | 8 | 1 | 3 | 5.9 | CCCCCCc1c(C(=O)c2cccc(C(=O)O)c2)c2cc(Cl)ccc2n1C | 10.1016/j.bmcl.2017.08.034 | ||
| CHEMBL4070005 | 156794 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay |
ChEMBL | 397 | 8 | 1 | 3 | 5.9 | CCCCCCc1c(C(=O)c2cccc(C(=O)O)c2)c2cc(Cl)ccc2n1C | 10.1016/j.bmcl.2017.08.034 | ||
| 49804576 | 87373 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis |
ChEMBL | 315 | 9 | 1 | 3 | 4.7 | CCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O | 10.1021/jm401292m | ||
| CHEMBL2332567 | 87373 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis |
ChEMBL | 315 | 9 | 1 | 3 | 4.7 | CCCCCCc1cc2ccccc2n1C(=O)CCCC(=O)O | 10.1021/jm401292m | ||
| 71717596 | 87371 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis |
ChEMBL | 265 | 4 | 1 | 3 | 3.2 | O=C(O)CCCC(=O)n1ccc2cc(Cl)ccc21 | 10.1021/jm400480j | ||
| CHEMBL2332561 | 87371 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis |
ChEMBL | 265 | 4 | 1 | 3 | 3.2 | O=C(O)CCCC(=O)n1ccc2cc(Cl)ccc21 | 10.1021/jm400480j | ||
| 49800562 | 87370 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis |
ChEMBL | 315 | 9 | 1 | 3 | 4.7 | CCCCCCc1cccc2ccn(C(=O)CCCC(=O)O)c12 | 10.1021/jm400480j | ||
| CHEMBL2332560 | 87370 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysisAntagonist activity at OXE receptor in human neutrophils assessed as 5-oxo-ETE-induced Ca2+ mobilization incubated for 2 mins prior to 5-oxo-ETE addition measured after 1 min by spectrofluorimetric analysis |
ChEMBL | 315 | 9 | 1 | 3 | 4.7 | CCCCCCc1cccc2ccn(C(=O)CCCC(=O)O)c12 | 10.1021/jm400480j | ||
| 145984927 | 166522 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay |
ChEMBL | 439 | 11 | 1 | 3 | 6.8 | CC(CC(=O)O)CC(=O)n1c(CCCCCCc2ccccc2)cc2ccc(Cl)cc21 | 10.1021/acs.jmedchem.8b00154 | ||
| CHEMBL4277299 | 166522 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay |
ChEMBL | 439 | 11 | 1 | 3 | 6.8 | CC(CC(=O)O)CC(=O)n1c(CCCCCCc2ccccc2)cc2ccc(Cl)cc21 | 10.1021/acs.jmedchem.8b00154 | ||
| 145984923 | 166517 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay |
ChEMBL | 469 | 12 | 2 | 4 | 6.4 | C[C@@H](CC(=O)O)CC(=O)c1c([C@@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 | 10.1021/acs.jmedchem.8b00154 | ||
| CHEMBL4277207 | 166517 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay |
ChEMBL | 469 | 12 | 2 | 4 | 6.4 | C[C@@H](CC(=O)O)CC(=O)c1c([C@@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 | 10.1021/acs.jmedchem.8b00154 | ||
| 137638047 | 156869 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay |
ChEMBL | 391 | 10 | 1 | 3 | 6.0 | CCCCCCc1c(C(=O)CC(C)(C)CC(=O)O)c2cc(Cl)ccc2n1C | 10.1016/j.bmcl.2017.08.034 | ||
| CHEMBL4070795 | 156869 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay |
ChEMBL | 391 | 10 | 1 | 3 | 6.0 | CCCCCCc1c(C(=O)CC(C)(C)CC(=O)O)c2cc(Cl)ccc2n1C | 10.1016/j.bmcl.2017.08.034 | ||
| 76336045 | 105363 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis |
ChEMBL | 343 | 9 | 1 | 3 | 5.2 | CCCCCCc1c(C)c2ccccc2n1C(=O)CC(C)CC(=O)O | 10.1021/jm401292m | ||
| CHEMBL3115783 | 105363 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis |
ChEMBL | 343 | 9 | 1 | 3 | 5.2 | CCCCCCc1c(C)c2ccccc2n1C(=O)CC(C)CC(=O)O | 10.1021/jm401292m | ||
| 137644937 | 158580 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay |
ChEMBL | 397 | 8 | 1 | 3 | 5.9 | CCCCCCc1c(C(=O)c2ccc(C(=O)O)cc2)c2cc(Cl)ccc2n1C | 10.1016/j.bmcl.2017.08.034 | ||
| CHEMBL4090987 | 158580 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | - | 1 | Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assayAntagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins followed by 5-oxo-ETE addition measured after 1 min by fluorescence assay |
ChEMBL | 397 | 8 | 1 | 3 | 5.9 | CCCCCCc1c(C(=O)c2ccc(C(=O)O)cc2)c2cc(Cl)ccc2n1C | 10.1016/j.bmcl.2017.08.034 | ||
| 49800561 | 105374 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | - | 1 | Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins prior to 5-oxo-ETE induction by spectrofluorometric analysis |
ChEMBL | 287 | 7 | 1 | 3 | 3.9 | CCCCc1cc2ccccc2n1C(=O)CCCC(=O)O | 10.1021/jm401292m | ||
Showing 1 to 50 of 253 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 49802029 | 105356 | None | 5 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysis |
ChEMBL | 363 | 9 | 1 | 3 | 5.6 | CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O | 10.1021/jm401292m | ||
| CHEMBL3115774 | 105356 | None | 5 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysis |
ChEMBL | 363 | 9 | 1 | 3 | 5.6 | CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O | 10.1021/jm401292m | ||
| 66644128 | 105357 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysis |
ChEMBL | 377 | 10 | 1 | 3 | 5.6 | CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C | 10.1021/jm401292m | ||
| CHEMBL3115775 | 105357 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysisAntagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin polymerization preincubated for 5 mins followed by 5-oxo-ETE induction measured after 20 secs by flow cytometric analysis |
ChEMBL | 377 | 10 | 1 | 3 | 5.6 | CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C | 10.1021/jm401292m | ||
| 49802029 | 105356 | None | 5 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysisAntagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysis |
ChEMBL | 363 | 9 | 1 | 3 | 5.6 | CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O | 10.1021/jm401292m | ||
| CHEMBL3115774 | 105356 | None | 5 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysisAntagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysis |
ChEMBL | 363 | 9 | 1 | 3 | 5.6 | CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(=O)O | 10.1021/jm401292m | ||
| 66644128 | 105357 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysisAntagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysis |
ChEMBL | 377 | 10 | 1 | 3 | 5.6 | CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C | 10.1021/jm401292m | ||
| CHEMBL3115775 | 105357 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysisAntagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs by hematoxylin/chromotrope 2R staining-based microscopic analysis |
ChEMBL | 377 | 10 | 1 | 3 | 5.6 | CCCCCCc1c(C(=O)CC(C)CC(=O)O)c2cc(Cl)ccc2n1C | 10.1021/jm401292m | ||
| 1051 | 1455 | None | 44 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis |
Drug Central | 328 | 14 | 1 | 1 | 6.5 | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O | None | ||
| 4289 | 1455 | None | 44 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis |
Drug Central | 328 | 14 | 1 | 1 | 6.5 | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O | None | ||
| 445580 | 1455 | None | 44 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis |
Drug Central | 328 | 14 | 1 | 1 | 6.5 | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O | None | ||
| 57417355 | 1455 | None | 44 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis |
Drug Central | 328 | 14 | 1 | 1 | 6.5 | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O | None | ||
| CHEMBL367149 | 1455 | None | 44 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis |
Drug Central | 328 | 14 | 1 | 1 | 6.5 | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O | None | ||
| DB03756 | 1455 | None | 44 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis |
Drug Central | 328 | 14 | 1 | 1 | 6.5 | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O | None | ||
| 3174 | 1570 | None | 51 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis |
Drug Central | 302 | 13 | 1 | 1 | 6.0 | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O | None | ||
| 3362 | 1570 | None | 51 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis |
Drug Central | 302 | 13 | 1 | 1 | 6.0 | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O | None | ||
| 446284 | 1570 | None | 51 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis |
Drug Central | 302 | 13 | 1 | 1 | 6.0 | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O | None | ||
| CHEMBL460026 | 1570 | None | 51 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis |
Drug Central | 302 | 13 | 1 | 1 | 6.0 | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O | None | ||
| DB00159 | 1570 | None | 51 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysisAntagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid scintillation counting analysis |
Drug Central | 302 | 13 | 1 | 1 | 6.0 | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O | None | ||
| 3391 | 155 | None | 17 | Human | Binding | pKd | = | 8.4 | 8.4 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 318 | 14 | 1 | 2 | 5.4 | CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O | 9829988 | ||
| 3416 | 155 | None | 17 | Human | Binding | pKd | = | 8.4 | 8.4 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 318 | 14 | 1 | 2 | 5.4 | CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O | 9829988 | ||
| 5283159 | 155 | None | 17 | Human | Binding | pKd | = | 8.4 | 8.4 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 318 | 14 | 1 | 2 | 5.4 | CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O | 9829988 | ||
| CHEMBL18028 | 155 | None | 17 | Human | Binding | pKd | = | 8.4 | 8.4 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 318 | 14 | 1 | 2 | 5.4 | CCCCC/C=C\C/C=C\C/C=C\C=C\C(=O)CCCC(=O)O | 9829988 | ||
Showing 1 to 23 of 23 entries