Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| CHEMBL1802413 | 211412 | None | 2 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetryAgonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetry |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm300507d | ||||
| CHEMBL1802413 | 211412 | None | 2 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm200418c | ||||
| 53363725 | 63849 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | 933 | 27 | 11 | 10 | -0.5 | CCN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN | 10.1021/jm200418c | ||
| CHEMBL1802479 | 63849 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | 933 | 27 | 11 | 10 | -0.5 | CCN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN | 10.1021/jm200418c | ||
| 71458840 | 82210 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetryAgonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetry |
ChEMBL | 844 | 26 | 12 | 11 | -3.2 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CN(CCO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm300507d | ||
| CHEMBL2170392 | 82210 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetryAgonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetry |
ChEMBL | 844 | 26 | 12 | 11 | -3.2 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CN(CCO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm300507d | ||
| 71462362 | 82212 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetryAgonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetry |
ChEMBL | 814 | 24 | 11 | 10 | -2.6 | CN(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN | 10.1021/jm300507d | ||
| CHEMBL2170397 | 82212 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetryAgonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetry |
ChEMBL | 814 | 24 | 11 | 10 | -2.6 | CN(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN | 10.1021/jm300507d | ||
| CHEMBL1802371 | 211407 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm200418c | ||||
| 56683368 | 63848 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | 982 | 26 | 11 | 12 | -0.9 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(N1CCCCC1)N1CCCCC1 | 10.1021/jm200418c | ||
| CHEMBL1802478 | 63848 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | 982 | 26 | 11 | 12 | -0.9 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(N1CCCCC1)N1CCCCC1 | 10.1021/jm200418c | ||
| CHEMBL1802412 | 211411 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | None | None | None | C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm200418c | ||||
| CHEMBL1802433 | 211427 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | None | None | None | C[C@H](NC(=O)CNC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm200418c | ||||
| 71456973 | 82208 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetryAgonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetry |
ChEMBL | 830 | 25 | 13 | 11 | -3.5 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm300507d | ||
| CHEMBL2170390 | 82208 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetryAgonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetry |
ChEMBL | 830 | 25 | 13 | 11 | -3.5 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm300507d | ||
| 71462363 | 82215 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetryAgonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetry |
ChEMBL | 897 | 26 | 11 | 10 | -0.6 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CN(CC1CCCCC1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm300507d | ||
| CHEMBL2170400 | 82215 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetryAgonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetry |
ChEMBL | 897 | 26 | 11 | 10 | -0.6 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CN(CC1CCCCC1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm300507d | ||
| 145991598 | 167087 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometeryAgonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometery |
ChEMBL | 843 | 25 | 12 | 10 | -2.4 | CCNC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01332 | ||
| CHEMBL4287860 | 167087 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometeryAgonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometery |
ChEMBL | 843 | 25 | 12 | 10 | -2.4 | CCNC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01332 | ||
| CHEMBL1802416 | 211415 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm200418c | ||||
| CHEMBL2170249 | 211809 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetryAgonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetry |
ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm300507d | ||||
| 145979256 | 166744 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometeryAgonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometery |
ChEMBL | 857 | 26 | 12 | 10 | -2.0 | CCCNC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01332 | ||
| CHEMBL4281383 | 166744 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometeryAgonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometery |
ChEMBL | 857 | 26 | 12 | 10 | -2.0 | CCCNC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01332 | ||
| CHEMBL1802484 | 211429 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | None | None | None | CC(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm200418c | ||||
| CHEMBL1802364 | 211400 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm200418c | ||||
| 145980372 | 166722 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | Agonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometeryAgonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometery |
ChEMBL | 871 | 26 | 12 | 10 | -1.8 | CC(C)CNC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01332 | ||
| CHEMBL4280889 | 166722 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | Agonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometeryAgonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometery |
ChEMBL | 871 | 26 | 12 | 10 | -1.8 | CC(C)CNC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01332 | ||
| CHEMBL1802368 | 211404 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | None | None | None | CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm200418c | ||||
| 71456975 | 82217 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetryAgonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetry |
ChEMBL | 854 | 25 | 10 | 10 | -0.9 | CCCN(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CN1CCNCC1 | 10.1021/jm300507d | ||
| CHEMBL2170402 | 82217 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetryAgonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetry |
ChEMBL | 854 | 25 | 10 | 10 | -0.9 | CCCN(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CN1CCNCC1 | 10.1021/jm300507d | ||
| CHEMBL1802425 | 211424 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | Agonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometeryAgonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometery |
ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01332 | ||||
| 53363629 | 63840 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | 3011 | 98 | 42 | 40 | -11.2 | CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(Cc1ccccc1)Cc1ccccc1 | 10.1021/jm200418c | ||
| 91932313 | 63840 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | 3011 | 98 | 42 | 40 | -11.2 | CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(Cc1ccccc1)Cc1ccccc1 | 10.1021/jm200418c | ||
| CHEMBL1802373 | 63840 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | 3011 | 98 | 42 | 40 | -11.2 | CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(Cc1ccccc1)Cc1ccccc1 | 10.1021/jm200418c | ||
| CHEMBL1802424 | 211423 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm200418c | ||||
| CHEMBL1802367 | 211403 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | None | None | None | CC(C)(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm200418c | ||||
| CHEMBL1802417 | 211416 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm200418c | ||||
| 145981604 | 166552 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | Agonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometeryAgonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometery |
ChEMBL | 829 | 25 | 12 | 10 | -2.7 | N=C(N)NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01332 | ||
| CHEMBL4277962 | 166552 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | - | 1 | Agonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometeryAgonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometery |
ChEMBL | 829 | 25 | 12 | 10 | -2.7 | N=C(N)NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01332 | ||
| CHEMBL1802369 | 211405 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | None | None | None | CCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm200418c | ||||
| CHEMBL1802423 | 211422 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm200418c | ||||
| 71451641 | 82209 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetryAgonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetry |
ChEMBL | 830 | 25 | 12 | 11 | -3.2 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)CN(Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm300507d | ||
| CHEMBL2170391 | 82209 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | Agonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetryAgonist activity at human GPR103 expressed in CHO cells co-expressing Galpha16 assessed as increase in intracellular calcium level measured for 2 mins by fluorimetry |
ChEMBL | 830 | 25 | 12 | 11 | -3.2 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)CN(Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm300507d | ||
| CHEMBL1802421 | 211420 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | None | None | None | N=C(N)NCCC[C@H](NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm200418c | ||||
| 56662955 | 63841 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | 899 | 25 | 12 | 10 | -1.8 | CC(C)(C)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm200418c | ||
| CHEMBL1802374 | 63841 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | 899 | 25 | 12 | 10 | -1.8 | CC(C)(C)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm200418c | ||
| 145990522 | 167131 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | Agonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometeryAgonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometery |
ChEMBL | 885 | 27 | 12 | 10 | -1.4 | CC(C)CNC(=N)NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01332 | ||
| CHEMBL4288785 | 167131 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | - | 1 | Agonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometeryAgonist activity at human QRFPR expressed in CHO cells co-expressing Galpha16 assessed as increase Ca2+ mobilization after 3 mins by Fluo-4 AM-based scanning fluorometery |
ChEMBL | 885 | 27 | 12 | 10 | -1.4 | CC(C)CNC(=N)NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/acs.jmedchem.8b01332 | ||
| 56683367 | 63847 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | 2997 | 96 | 42 | 42 | -12.8 | CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(N1CCCCC1)N1CCCCC1 | 10.1021/jm200418c | ||
| 91932314 | 63847 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | Agonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysisAgonist activity at DYKDDDDK-flagged human GPR103 receptor expressed in CHO-K1 cells co-expressing G-protein alpha16 assessed as stimulation of calcium mobilization after 2 mins by fluorometric analysis |
ChEMBL | 2997 | 96 | 42 | 42 | -12.8 | CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(N1CCCCC1)N1CCCCC1 | 10.1021/jm200418c | ||
Showing 1 to 50 of 177 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| CHEMBL1802413 | 211412 | None | 2 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | Displacement of [125I]26RFa from human GPR103 expressed in HEK293 cells incubated for 1 h by gamma counter based methodDisplacement of [125I]26RFa from human GPR103 expressed in HEK293 cells incubated for 1 h by gamma counter based method |
ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm300507d | ||||
| 90644575 | 111965 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 360 | 6 | 2 | 4 | 5.7 | COc1ccc(NC(=N)c2cc(C)cs2)cc1CSC1CCCC1 | 10.1021/ml400519h | ||
| CHEMBL3287811 | 111965 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 360 | 6 | 2 | 4 | 5.7 | COc1ccc(NC(=N)c2cc(C)cs2)cc1CSC1CCCC1 | 10.1021/ml400519h | ||
| 90644566 | 111978 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 330 | 5 | 2 | 3 | 5.7 | Cc1ccc(NC(=N)c2cccs2)cc1CSC1CCCC1 | 10.1021/ml400519h | ||
| CHEMBL3287826 | 111978 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 330 | 5 | 2 | 3 | 5.7 | Cc1ccc(NC(=N)c2cccs2)cc1CSC1CCCC1 | 10.1021/ml400519h | ||
| 90644569 | 111983 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 330 | 6 | 2 | 4 | 4.7 | COc1ccc(NC(=N)c2cccs2)cc1COC1CCCC1 | 10.1021/ml400519h | ||
| CHEMBL3287832 | 111983 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 330 | 6 | 2 | 4 | 4.7 | COc1ccc(NC(=N)c2cccs2)cc1COC1CCCC1 | 10.1021/ml400519h | ||
| 78210300 | 1047 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | Inhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assayInhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assay |
ChEMBL | 440 | 3 | 0 | 4 | 4.2 | CN(Cc1ccc2c(c1)C(C)CN(C2)C(=O)c1cc2c(n1C)cnc(c2)Br)C | 10.1021/jm401951t | ||
| 9443 | 1047 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | Inhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assayInhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assay |
ChEMBL | 440 | 3 | 0 | 4 | 4.2 | CN(Cc1ccc2c(c1)C(C)CN(C2)C(=O)c1cc2c(n1C)cnc(c2)Br)C | 10.1021/jm401951t | ||
| CHEMBL3314358 | 1047 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | Inhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assayInhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assay |
ChEMBL | 440 | 3 | 0 | 4 | 4.2 | CN(Cc1ccc2c(c1)C(C)CN(C2)C(=O)c1cc2c(n1C)cnc(c2)Br)C | 10.1021/jm401951t | ||
| 90644574 | 111872 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 346 | 6 | 2 | 4 | 5.4 | COc1ccc(NC(=N)c2ccsc2)cc1CSC1CCCC1 | 10.1021/ml400519h | ||
| CHEMBL3287586 | 111872 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 346 | 6 | 2 | 4 | 5.4 | COc1ccc(NC(=N)c2ccsc2)cc1CSC1CCCC1 | 10.1021/ml400519h | ||
| 90644577 | 111967 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 424 | 6 | 2 | 4 | 6.1 | COc1ccc(NC(=N)c2ccc(Br)s2)cc1CSC1CCCC1 | 10.1021/ml400519h | ||
| CHEMBL3287813 | 111967 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 424 | 6 | 2 | 4 | 6.1 | COc1ccc(NC(=N)c2ccc(Br)s2)cc1CSC1CCCC1 | 10.1021/ml400519h | ||
| 90644567 | 111979 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 334 | 5 | 2 | 3 | 5.5 | N=C(Nc1ccc(F)c(CSC2CCCC2)c1)c1cccs1 | 10.1021/ml400519h | ||
| CHEMBL3287827 | 111979 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 334 | 5 | 2 | 3 | 5.5 | N=C(Nc1ccc(F)c(CSC2CCCC2)c1)c1cccs1 | 10.1021/ml400519h | ||
| 118707555 | 113234 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Inhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assayInhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assay |
ChEMBL | 474 | 3 | 0 | 4 | 3.4 | CN(C)Cc1ccc2c(c1)CCN(C(=O)c1cc3cc(I)ncc3n1C)C2 | 10.1021/jm401951t | ||
| CHEMBL3314354 | 113234 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Inhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assayInhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assay |
ChEMBL | 474 | 3 | 0 | 4 | 3.4 | CN(C)Cc1ccc2c(c1)CCN(C(=O)c1cc3cc(I)ncc3n1C)C2 | 10.1021/jm401951t | ||
| 90644573 | 111870 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 346 | 6 | 2 | 4 | 5.4 | COc1ccc(NC(=N)c2cccs2)cc1CSC1CCCC1 | 10.1021/ml400519h | ||
| CHEMBL3287584 | 111870 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 346 | 6 | 2 | 4 | 5.4 | COc1ccc(NC(=N)c2cccs2)cc1CSC1CCCC1 | 10.1021/ml400519h | ||
| 118707554 | 113233 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | Inhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assayInhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assay |
ChEMBL | 362 | 3 | 0 | 4 | 3.1 | Cc1cc2cc(C(=O)N3CCc4cc(CN(C)C)ccc4C3)n(C)c2cn1 | 10.1021/jm401951t | ||
| CHEMBL3314353 | 113233 | None | 0 | Human | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | Inhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assayInhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assay |
ChEMBL | 362 | 3 | 0 | 4 | 3.1 | Cc1cc2cc(C(=O)N3CCc4cc(CN(C)C)ccc4C3)n(C)c2cn1 | 10.1021/jm401951t | ||
| 90644570 | 111984 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 322 | 6 | 2 | 2 | 5.3 | COc1ccc(NC(=N)c2ccccc2)cc1CCC1CCCC1 | 10.1021/ml400519h | ||
| CHEMBL3287833 | 111984 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 322 | 6 | 2 | 2 | 5.3 | COc1ccc(NC(=N)c2ccccc2)cc1CCC1CCCC1 | 10.1021/ml400519h | ||
| 71458843 | 82218 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Displacement of [125I]26RFa from human GPR103 expressed in HEK293 cells incubated for 1 h by gamma counter based methodDisplacement of [125I]26RFa from human GPR103 expressed in HEK293 cells incubated for 1 h by gamma counter based method |
ChEMBL | 886 | 26 | 12 | 12 | -3.0 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CN(CC(O)CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm300507d | ||
| CHEMBL2170403 | 82218 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | Displacement of [125I]26RFa from human GPR103 expressed in HEK293 cells incubated for 1 h by gamma counter based methodDisplacement of [125I]26RFa from human GPR103 expressed in HEK293 cells incubated for 1 h by gamma counter based method |
ChEMBL | 886 | 26 | 12 | 12 | -3.0 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CN(CC(O)CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CN1CCNCC1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm300507d | ||
| 118707553 | 113232 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Inhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assayInhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assay |
ChEMBL | 426 | 3 | 0 | 4 | 3.6 | CN(C)Cc1ccc2c(c1)CCN(C(=O)c1cc3cc(Br)ncc3n1C)C2 | 10.1021/jm401951t | ||
| CHEMBL3314352 | 113232 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Inhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assayInhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assay |
ChEMBL | 426 | 3 | 0 | 4 | 3.6 | CN(C)Cc1ccc2c(c1)CCN(C(=O)c1cc3cc(Br)ncc3n1C)C2 | 10.1021/jm401951t | ||
| 86302643 | 111964 | None | 1 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 340 | 6 | 2 | 3 | 5.3 | COc1ccc(NC(=N)c2ccccc2)cc1CSC1CCCC1 | 10.1021/ml400519h | ||
| CHEMBL3287810 | 111964 | None | 1 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 340 | 6 | 2 | 3 | 5.3 | COc1ccc(NC(=N)c2ccccc2)cc1CSC1CCCC1 | 10.1021/ml400519h | ||
| 90644565 | 111977 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 316 | 5 | 2 | 3 | 5.4 | N=C(Nc1cccc(CSC2CCCC2)c1)c1cccs1 | 10.1021/ml400519h | ||
| CHEMBL3287825 | 111977 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 316 | 5 | 2 | 3 | 5.4 | N=C(Nc1cccc(CSC2CCCC2)c1)c1cccs1 | 10.1021/ml400519h | ||
| 90644581 | 111970 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 347 | 6 | 2 | 5 | 4.8 | COc1ccc(NC(=N)c2nccs2)cc1CSC1CCCC1 | 10.1021/ml400519h | ||
| CHEMBL3287817 | 111970 | None | 0 | Human | Binding | pIC50 | = | 4.6 | 4.6 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 347 | 6 | 2 | 5 | 4.8 | COc1ccc(NC(=N)c2nccs2)cc1CSC1CCCC1 | 10.1021/ml400519h | ||
| 118707553 | 113232 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Displacement of [125I]QRFP43 from human GPR103 receptor expressed in HEK cells after 90 mins incubation by scintillation countingDisplacement of [125I]QRFP43 from human GPR103 receptor expressed in HEK cells after 90 mins incubation by scintillation counting |
ChEMBL | 426 | 3 | 0 | 4 | 3.6 | CN(C)Cc1ccc2c(c1)CCN(C(=O)c1cc3cc(Br)ncc3n1C)C2 | 10.1021/jm401951t | ||
| CHEMBL3314352 | 113232 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | Displacement of [125I]QRFP43 from human GPR103 receptor expressed in HEK cells after 90 mins incubation by scintillation countingDisplacement of [125I]QRFP43 from human GPR103 receptor expressed in HEK cells after 90 mins incubation by scintillation counting |
ChEMBL | 426 | 3 | 0 | 4 | 3.6 | CN(C)Cc1ccc2c(c1)CCN(C(=O)c1cc3cc(Br)ncc3n1C)C2 | 10.1021/jm401951t | ||
| 118707552 | 113231 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | Inhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assayInhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assay |
ChEMBL | 348 | 3 | 0 | 4 | 2.8 | CN(C)Cc1ccc2c(c1)CCN(C(=O)c1cc3ccncc3n1C)C2 | 10.1021/jm401951t | ||
| CHEMBL3314351 | 113231 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | Inhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assayInhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assay |
ChEMBL | 348 | 3 | 0 | 4 | 2.8 | CN(C)Cc1ccc2c(c1)CCN(C(=O)c1cc3ccncc3n1C)C2 | 10.1021/jm401951t | ||
| 71456973 | 82208 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | Displacement of [125I]26RFa from human GPR103 expressed in HEK293 cells incubated for 1 h by gamma counter based methodDisplacement of [125I]26RFa from human GPR103 expressed in HEK293 cells incubated for 1 h by gamma counter based method |
ChEMBL | 830 | 25 | 13 | 11 | -3.5 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm300507d | ||
| CHEMBL2170390 | 82208 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | Displacement of [125I]26RFa from human GPR103 expressed in HEK293 cells incubated for 1 h by gamma counter based methodDisplacement of [125I]26RFa from human GPR103 expressed in HEK293 cells incubated for 1 h by gamma counter based method |
ChEMBL | 830 | 25 | 13 | 11 | -3.5 | N=C(N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNNC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm300507d | ||
| 118707557 | 113236 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | Inhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assayInhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assay |
ChEMBL | 416 | 3 | 0 | 4 | 3.9 | CN(C)Cc1ccc2c(c1)CCN(C(=O)c1cc3cc(C(F)(F)F)ncc3n1C)C2 | 10.1021/jm401951t | ||
| CHEMBL3314356 | 113236 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | Inhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assayInhibition of human GPR103 receptor expressed in CHOK1 cells by IP-1 assay |
ChEMBL | 416 | 3 | 0 | 4 | 3.9 | CN(C)Cc1ccc2c(c1)CCN(C(=O)c1cc3cc(C(F)(F)F)ncc3n1C)C2 | 10.1021/jm401951t | ||
| 90644578 | 111968 | None | 1 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 374 | 6 | 2 | 3 | 6.0 | COc1ccc(NC(=N)c2ccc(Cl)cc2)cc1CSC1CCCC1 | 10.1021/ml400519h | ||
| CHEMBL3287814 | 111968 | None | 1 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 374 | 6 | 2 | 3 | 6.0 | COc1ccc(NC(=N)c2ccc(Cl)cc2)cc1CSC1CCCC1 | 10.1021/ml400519h | ||
| 90644564 | 111976 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 340 | 6 | 2 | 3 | 5.3 | COc1ccc(C(=N)Nc2ccccc2)cc1CSC1CCCC1 | 10.1021/ml400519h | ||
| CHEMBL3287824 | 111976 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 340 | 6 | 2 | 3 | 5.3 | COc1ccc(C(=N)Nc2ccccc2)cc1CSC1CCCC1 | 10.1021/ml400519h | ||
| 90644568 | 111980 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 350 | 5 | 2 | 3 | 6.0 | N=C(Nc1ccc(Cl)c(CSC2CCCC2)c1)c1cccs1 | 10.1021/ml400519h | ||
| CHEMBL3287828 | 111980 | None | 0 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation countingDisplacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting |
ChEMBL | 350 | 5 | 2 | 3 | 6.0 | N=C(Nc1ccc(Cl)c(CSC2CCCC2)c1)c1cccs1 | 10.1021/ml400519h | ||
| 118707562 | 113240 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | Displacement of [125I]QRFP43 from human GPR103 receptor expressed in HEK cells after 90 mins incubation by scintillation countingDisplacement of [125I]QRFP43 from human GPR103 receptor expressed in HEK cells after 90 mins incubation by scintillation counting |
ChEMBL | 395 | 3 | 0 | 3 | 4.4 | Cc1cc2c(cc1CN(C)C)CCN(C(=O)c1cc3cc(Cl)ccc3n1C)C2 | 10.1021/jm401951t | ||
| CHEMBL3314362 | 113240 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | Displacement of [125I]QRFP43 from human GPR103 receptor expressed in HEK cells after 90 mins incubation by scintillation countingDisplacement of [125I]QRFP43 from human GPR103 receptor expressed in HEK cells after 90 mins incubation by scintillation counting |
ChEMBL | 395 | 3 | 0 | 3 | 4.4 | Cc1cc2c(cc1CN(C)C)CCN(C(=O)c1cc3cc(Cl)ccc3n1C)C2 | 10.1021/jm401951t | ||
Showing 1 to 50 of 82 entries