GPCRdb

Ligand source activities (1 row/activity)

Potency
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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	122653602	184244	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	8	2	6	3.7	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NC5CCN(CCO)CC5)cccc43)c2)cc1F	nan
	CHEMBL4852000	184244	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	8	2	6	3.7	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NC5CCN(CCO)CC5)cccc43)c2)cc1F	nan
	122653721	183816	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	CHEMBL4845846	183816	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	122653713	183851	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4846330	183851	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1	nan
	122653650	183852	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1cc(Cl)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4846333	183852	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1cc(Cl)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653704	183856	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	409	6	2	4	3.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	CHEMBL4846416	183856	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	409	6	2	4	3.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	122653665	183870	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	510	7	2	5	4.0	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4846586	183870	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	510	7	2	5	4.0	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653719	183880	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccnc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4846775	183880	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccnc(C(F)(F)F)c2)ccn1	nan
	122653649	183886	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cccc(Cc2cccc(C(F)(F)F)c2)n1	nan
	CHEMBL4846914	183886	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cccc(Cc2cccc(C(F)(F)F)c2)n1	nan
	122653642	183894	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4846977	183894	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653806	183939	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	486	7	1	4	4.8	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4847685	183939	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	486	7	1	4	4.8	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653408	183941	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	475	7	3	5	3.0	O=C(NC[C@@H](O)CO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4847708	183941	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	475	7	3	5	3.0	O=C(NC[C@@H](O)CO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653470	183945	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NC[C@@H](O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4847735	183945	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NC[C@@H](O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653679	183977	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	5	2.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(Cl)nc2)ccn1	nan
	CHEMBL4848378	183977	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	5	2.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(Cl)nc2)ccn1	nan
	122653688	183978	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4848379	183978	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653654	183997	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	436	5	1	4	4.6	N#CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4848606	183997	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	436	5	1	4	4.6	N#CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653571	184006	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	CHEMBL4848812	184006	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	122653464	184029	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	2	4	4.2	O=C(NCC(O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4849056	184029	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	2	4	4.2	O=C(NCC(O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653683	184042	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	465	9	2	6	3.3	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(OC)c(F)c2)ccn1	nan
	CHEMBL4849398	184042	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	465	9	2	6	3.3	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(OC)c(F)c2)ccn1	nan
	122653417	184067	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4849645	184067	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653491	184072	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	368	4	2	3	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc3[nH]ccc23)ccn1	nan
	CHEMBL4849698	184072	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	368	4	2	3	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc3[nH]ccc23)ccn1	nan
	122653696	184091	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	5	1	4	4.5	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1C(F)(F)F	nan
	CHEMBL4849904	184091	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	5	1	4	4.5	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1C(F)(F)F	nan
	122653579	184096	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4849970	184096	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653601	184105	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(C(F)(F)F)c2)ccn1	nan
	CHEMBL4850054	184105	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(C(F)(F)F)c2)ccn1	nan
	122653613	184143	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	6	2	4	4.4	Cc1c(Cc2cccc(C(F)(F)F)c2)ccnc1N1CCc2c(C(=O)NCCO)cccc21	nan
	CHEMBL4850541	184143	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	6	2	4	4.4	Cc1c(Cc2cccc(C(F)(F)F)c2)ccnc1N1CCc2c(C(=O)NCCO)cccc21	nan
	122653676	184162	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4850812	184162	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1	nan
	122653686	184173	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	6	2	4	3.5	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4850965	184173	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	6	2	4	3.5	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653731	184180	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	460	6	2	5	3.1	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)N[C@H]5CCNC5=O)cccc43)c2)cc1F	nan
	CHEMBL4851069	184180	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	460	6	2	5	3.1	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)N[C@H]5CCNC5=O)cccc43)c2)cc1F	nan
	122653592	184199	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	379	4	1	3	4.0	CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	CHEMBL4851368	184199	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	379	4	1	3	4.0	CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	122653436	184200	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	9	2	5	3.5	O=C(NCCOCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4851394	184200	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	9	2	5	3.5	O=C(NCCOCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653690	184206	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	369	4	1	4	4.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4851533	184206	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	369	4	1	4	4.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653558	184207	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4851577	184207	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653573	184226	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	394	5	1	5	3.5	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1Cl	nan
	CHEMBL4851800	184226	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	394	5	1	5	3.5	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1Cl	nan
	122653608	184236	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	7	2	5	3.3	CC(=O)c1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ccn2)c1	nan
	CHEMBL4851936	184236	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	7	2	5	3.3	CC(=O)c1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ccn2)c1	nan
	122653448	184258	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(Cl)c2)ccn1	nan
	CHEMBL4852273	184258	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(Cl)c2)ccn1	nan
	122653452	184264	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	4	1	4	3.4	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	CHEMBL4852339	184264	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	4	1	4	3.4	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	122653453	184271	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@H](O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4852404	184271	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@H](O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653427	184297	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	373	4	1	5	3.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)OCO3)ccn1	nan
	CHEMBL4852734	184297	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	373	4	1	5	3.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)OCO3)ccn1	nan
	122653420	184322	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	5	3.8	O=C(N[C@H]1CCOC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4853193	184322	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	5	3.8	O=C(N[C@H]1CCOC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122654155	184340	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	429	6	1	3	4.5	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4853351	184340	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	429	6	1	3	4.5	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653581	184353	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4853555	184353	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653658	184354	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	483	7	2	5	3.5	O=C(NCC1(CO)COC1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4853557	184354	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	483	7	2	5	3.5	O=C(NCC1(CO)COC1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653641	184362	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	348	4	1	5	3.1	Cc1noc(C)c1Cc1ccnc(N2CCc3c(C(N)=O)cccc32)c1	nan
	CHEMBL4853689	184362	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	348	4	1	5	3.1	Cc1noc(C)c1Cc1ccnc(N2CCc3c(C(N)=O)cccc32)c1	nan
	122653547	184372	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	391	6	1	4	4.0	CCOc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4853824	184372	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	391	6	1	4	4.0	CCOc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653619	184379	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	429	6	1	3	4.5	O=C(NCCF)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4853939	184379	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	429	6	1	3	4.5	O=C(NCCF)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653645	184391	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4854092	184391	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653725	184393	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4854146	184393	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653537	184396	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	494	5	1	4	5.2	CN1CCC(NC(=O)c2cccc3c2CCN3c2cc(Cc3cccc(C(F)(F)F)c3)ccn2)CC1	nan
	CHEMBL4854218	184396	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	494	5	1	4	5.2	CN1CCC(NC(=O)c2cccc3c2CCN3c2cc(Cc3cccc(C(F)(F)F)c3)ccn2)CC1	nan
	122653488	184423	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@H](O)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4854701	184423	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@H](O)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653599	184429	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	319	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccoc2)ccn1	nan
	CHEMBL4854849	184429	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	319	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccoc2)ccn1	nan
	122653722	184445	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4855055	184445	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653455	184449	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NCC(O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4855110	184449	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NCC(O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653627	184459	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	452	7	1	4	4.5	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4855290	184459	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	452	7	1	4	4.5	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653632	184475	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	494	7	1	4	4.1	O=C(NCCN1CCCC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4855414	184475	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	494	7	1	4	4.1	O=C(NCCN1CCCC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653486	184486	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4855646	184486	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653810	184496	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	4	1	3	5.1	CNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)cc(C)n1	nan
	CHEMBL4855829	184496	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	4	1	3	5.1	CNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)cc(C)n1	nan
	122653618	184506	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	6	1	4	4.8	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4856011	184506	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	6	1	4	4.8	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	164609725	184514	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	447	7	1	4	5.2	O=C(NCC(F)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4856051	184514	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	447	7	1	4	5.2	O=C(NCC(F)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	164609750	184540	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	536	8	2	5	4.7	O=C(NCC(O)Cc1cccnc1)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4856315	184540	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	536	8	2	5	4.7	O=C(NCC(O)Cc1cccnc1)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	164614108	184548	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	8	1	5	4.8	COC[C@@H](F)CNC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4856557	184548	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	8	1	5	4.8	COC[C@@H](F)CNC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	164614116	184553	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	524	8	1	5	4.8	O=C(NCCCN1CCOCC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4856676	184553	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	524	8	1	5	4.8	O=C(NCCCN1CCOCC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653723	184560	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	359	5	1	4	3.5	COc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4856786	184560	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	359	5	1	4	3.5	COc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653607	184565	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4856937	184565	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653609	184648	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4858042	184648	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653629	184649	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	361	5	1	6	2.3	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	CHEMBL4858047	184649	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	361	5	1	6	2.3	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	122653504	184656	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	483	5	1	4	4.1	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)c[n+]([O-])c1	nan
	CHEMBL4858187	184656	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	483	5	1	4	4.1	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)c[n+]([O-])c1	nan
	122653540	184663	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4858311	184663	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653412	184672	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	7	2	4	4.5	O=C(NCCc1cnc[nH]1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4858448	184672	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	7	2	4	4.5	O=C(NCCc1cnc[nH]1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653473	184680	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	486	7	2	4	3.8	CC(=O)NCCNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4858574	184680	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	486	7	2	4	3.8	CC(=O)NCCNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653489	184744	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	378	5	1	5	3.0	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4859593	184744	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	378	5	1	5	3.0	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653708	184764	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	383	4	1	3	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4860064	184764	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	383	4	1	3	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653667	184777	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	6	2	5	3.8	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4860274	184777	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	6	2	5	3.8	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653407	184780	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4860294	184780	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653481	184833	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	516	8	2	6	3.9	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(=O)NC5CCN(CCO)CC5)cccc43)c2)ccc1F	nan
	CHEMBL4861199	184833	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	516	8	2	6	3.9	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(=O)NC5CCN(CCO)CC5)cccc43)c2)ccc1F	nan
	122653808	184852	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	498	7	2	6	3.5	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	CHEMBL4861454	184852	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	498	7	2	6	3.5	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	122653426	184881	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	480	5	2	4	3.8	O=C1CCC(NC(=O)c2cccc3c2CCN3c2cc(Cc3cc(F)c(F)c(F)c3)ccn2)CN1	nan
	CHEMBL4861879	184881	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	480	5	2	4	3.8	O=C1CCC(NC(=O)c2cccc3c2CCN3c2cc(Cc3cc(F)c(F)c(F)c3)ccn2)CN1	nan
	122653405	184887	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4861950	184887	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653749	184924	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	475	7	3	5	3.0	O=C(NC(CO)CO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4862500	184924	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	475	7	3	5	3.0	O=C(NC(CO)CO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653745	184929	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	8	2	6	3.3	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCC5(CO)COC5)cccc43)c2)cc1F	nan
	CHEMBL4862529	184929	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	8	2	6	3.3	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCC5(CO)COC5)cccc43)c2)cc1F	nan
	122653500	184966	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	8	2	5	3.7	COC[C@@H](O)CNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4863091	184966	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	8	2	5	3.7	COC[C@@H](O)CNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653416	184971	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	7	2	4	4.5	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4863198	184971	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	7	2	4	4.5	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653669	184991	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	417	4	1	4	4.8	NC(=O)c1cccc2c1CCN2c1cc(Oc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4863386	184991	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	417	4	1	4	4.8	NC(=O)c1cccc2c1CCN2c1cc(Oc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653624	184996	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	364	4	1	4	3.5	NC(=O)c1cccc2c1CCN2c1cc(Cc2cncc(Cl)c2)ccn1	nan
	CHEMBL4863447	184996	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	364	4	1	4	3.5	NC(=O)c1cccc2c1CCN2c1cc(Cc2cncc(Cl)c2)ccn1	nan
	122653435	185002	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	439	7	2	5	3.4	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCO)c2)cc1F	nan
	CHEMBL4863562	185002	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	439	7	2	5	3.4	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCO)c2)cc1F	nan
	122653567	185003	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4863576	185003	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653804	185005	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	464	5	2	4	3.8	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4863613	185005	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	464	5	2	4	3.8	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653543	185010	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	452	5	2	5	3.7	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4863658	185010	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	452	5	2	5	3.7	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653554	185023	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	9	2	6	3.9	O=C(NCCOCCO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4863892	185023	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	9	2	6	3.9	O=C(NCCOCCO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653694	185033	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4864049	185033	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653480	185055	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4864397	185055	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653747	185061	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)n2)ccn1	nan
	CHEMBL4864476	185061	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)n2)ccn1	nan
	122653506	185088	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4864933	185088	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653610	185095	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4865057	185095	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653750	185100	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1Cl	nan
	CHEMBL4865124	185100	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1Cl	nan
	122653520	185101	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	508	7	2	5	4.3	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4865128	185101	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	508	7	2	5	4.3	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653728	185130	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4865653	185130	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653434	185141	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4865786	185141	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653569	185146	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2ccc(F)c(C(F)(F)F)c2)c1	nan
	CHEMBL4865910	185146	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2ccc(F)c(C(F)(F)F)c2)c1	nan
	122653712	185151	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(Cl)c(F)c2)ccn1	nan
	CHEMBL4865996	185151	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(Cl)c(F)c2)ccn1	nan
	122653803	185161	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4866193	185161	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653465	185183	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	319	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccco2)ccn1	nan
	CHEMBL4866434	185183	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	319	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccco2)ccn1	nan
	122653620	185186	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	6	2	4	4.5	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4866463	185186	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	6	2	4	4.5	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653724	185193	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@@H](O)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4866543	185193	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@@H](O)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653706	185200	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	2	4	4.2	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4866626	185200	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	2	4	4.2	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122660774	185207	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2cc(N3CCc4c(C(=O)NC[C@@H](O)CF)cccc43)ccn2)cc1F	nan
	CHEMBL4866746	185207	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2cc(N3CCc4c(C(=O)NC[C@@H](O)CF)cccc43)ccn2)cc1F	nan
	122653748	185214	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.3	C[C@H](O)[C@@H](CO)NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4866874	185214	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.3	C[C@H](O)[C@@H](CO)NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653717	185228	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)n2)ccn1	nan
	CHEMBL4867044	185228	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)n2)ccn1	nan
	122653680	185267	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	524	7	2	5	4.6	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4867659	185267	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	524	7	2	5	4.6	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653626	185268	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COCC(O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4867681	185268	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COCC(O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653477	185296	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1cc(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4868214	185296	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1cc(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653697	185314	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	373	5	1	4	3.8	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1C	nan
	CHEMBL4868562	185314	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	373	5	1	4	3.8	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1C	nan
	122653462	185319	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4868643	185319	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653545	185327	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	380	4	1	4	4.0	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc3ncccc23)ccn1	nan
	CHEMBL4868799	185327	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	380	4	1	4	4.0	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc3ncccc23)ccn1	nan
	122653419	185335	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	7	1	4	4.4	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCF)c2)cc1F	nan
	CHEMBL4868949	185335	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	7	1	4	4.4	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCF)c2)cc1F	nan
	122653460	185336	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	6	2	5	3.0	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	CHEMBL4869015	185336	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	6	2	5	3.0	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	122653519	185339	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4869072	185339	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653693	185344	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	7	2	4	3.9	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4869130	185344	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	7	2	4	3.9	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653518	185345	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4869139	185345	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653692	185354	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	389	5	1	4	3.8	CC(=O)c1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4869262	185354	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	389	5	1	4	3.8	CC(=O)c1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653691	185356	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	5	2	4	3.5	O=C(N[C@@H]1CCNC1=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4869305	185356	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	5	2	4	3.5	O=C(N[C@@H]1CCNC1=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653630	185367	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	8	2	5	3.7	COC[C@H](O)CNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4869524	185367	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	8	2	5	3.7	COC[C@H](O)CNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653483	185400	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4869851	185400	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653648	185404	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	395	5	1	4	3.8	COc1c(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4870024	185404	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	395	5	1	4	3.8	COc1c(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653406	185405	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	2	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(CO)c(F)c2)ccn1	nan
	CHEMBL4870029	185405	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	2	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(CO)c(F)c2)ccn1	nan
	122653709	185458	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	355	4	1	5	2.7	N#Cc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	CHEMBL4870751	185458	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	355	4	1	5	2.7	N#Cc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	122653458	185465	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4870894	185465	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653638	185467	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	2	4	3.7	CC(=O)NCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4870900	185467	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	2	4	3.7	CC(=O)NCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653428	185478	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	5	4.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4871052	185478	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	5	4.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ccn1	nan
	122653751	185492	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(F)c2)ccn1	nan
	CHEMBL4871344	185492	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(F)c2)ccn1	nan
	122653586	185550	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	7	1	5	4.4	O=C(NCCn1ccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4871971	185550	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	7	1	5	4.4	O=C(NCCn1ccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653589	185556	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(Cl)c2)ccn1	nan
	CHEMBL4872112	185556	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(Cl)c2)ccn1	nan
	122653461	185562	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4872227	185562	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653597	185572	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	542	7	2	5	4.7	O=C(NC1CCN(CCO)CC1)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4872358	185572	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	542	7	2	5	4.7	O=C(NC1CCN(CCO)CC1)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122660773	185676	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2cc(N3CCc4c(C(=O)NC[C@H](O)CF)cccc43)ccn2)cc1F	nan
	CHEMBL4873801	185676	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2cc(N3CCc4c(C(=O)NC[C@H](O)CF)cccc43)ccn2)cc1F	nan
	122653482	185677	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4873808	185677	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653628	185692	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4874029	185692	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653590	185731	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4874627	185731	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653603	185767	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	458	5	1	4	5.8	O=C(Nc1ccncc1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4875102	185767	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	458	5	1	4	5.8	O=C(Nc1ccncc1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653521	185770	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1ccccn1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4875163	185770	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1ccccn1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	164629075	185778	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	508	8	1	4	5.6	O=C(NCCCN1CCCC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4875342	185778	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	508	8	1	4	5.6	O=C(NCCCN1CCCC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653698	185784	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	435	5	1	4	4.2	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	CHEMBL4875443	185784	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	435	5	1	4	4.2	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	122653514	185797	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	5	2	4	3.5	O=C(N[C@H]1CCNC1=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4875637	185797	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	5	2	4	3.5	O=C(N[C@H]1CCNC1=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122654150	185832	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	363	4	2	4	3.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(O)c2)ccn1	nan
	CHEMBL4876057	185832	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	363	4	2	4	3.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(O)c2)ccn1	nan
	122653705	185835	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	360	5	1	5	2.9	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	CHEMBL4876095	185835	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	360	5	1	5	2.9	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	122653595	185849	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	382	4	1	4	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(F)c(Cl)c2)ccn1	nan
	CHEMBL4876282	185849	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	382	4	1	4	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(F)c(Cl)c2)ccn1	nan
	122653585	185866	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	1	4	4.7	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4876504	185866	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	1	4	4.7	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653634	185894	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@H](F)CO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4876839	185894	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@H](F)CO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653720	185916	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	421	7	2	5	3.2	COc1cc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)ccc1F	nan
	CHEMBL4877278	185916	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	421	7	2	5	3.2	COc1cc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)ccc1F	nan
	122653695	185917	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1ccncc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4877331	185917	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1ccncc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653677	185927	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(C(F)(F)F)c2)ccn1	nan
	CHEMBL4877494	185927	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(C(F)(F)F)c2)ccn1	nan
	122653672	185930	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1Cl	nan
	CHEMBL4877524	185930	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1Cl	nan
	122653640	185947	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1cc(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4877713	185947	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1cc(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653538	185959	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)n1	nan
	CHEMBL4877909	185959	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)n1	nan
	122653534	185975	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)c[n+]([O-])c1	nan
	CHEMBL4878069	185975	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)c[n+]([O-])c1	nan
	122653451	185978	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4878142	185978	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653510	185984	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	389	5	1	4	3.8	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	CHEMBL4878221	185984	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	389	5	1	4	3.8	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	122653549	186004	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NC[C@@H](F)CO)cccc43)c2)cc1F	nan
	CHEMBL4878529	186004	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NC[C@@H](F)CO)cccc43)c2)cc1F	nan
	122653729	186013	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4878629	186013	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653583	186040	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NCC(O)CF)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4879330	186040	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NCC(O)CF)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653714	185320	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4868685	185320	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653423	184958	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	433	7	2	5	3.4	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)ccc1F	nan
	CHEMBL4862971	184958	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	433	7	2	5	3.4	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)ccc1F	nan
	122653512	185569	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	480	8	2	5	3.5	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCNC(C)=O)c2)cc1F	nan
	CHEMBL4872333	185569	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	480	8	2	5	3.5	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCNC(C)=O)c2)cc1F	nan
	162676039	182881	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	456	6	2	6	3.1	O=C(c1cccc(C(F)(F)F)c1)c1cc(N2CCc3c(C(=O)NCCO)cccc32)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4799062	182881	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	456	6	2	6	3.1	O=C(c1cccc(C(F)(F)F)c1)c1cc(N2CCc3c(C(=O)NCCO)cccc32)ncn1	10.1021/acs.jmedchem.0c01498
	162662654	181311	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4779158	181311	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	122653659	183963	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cccc(Cc2cccc(C(F)(F)F)c2)n1	nan
	CHEMBL4848041	183963	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cccc(Cc2cccc(C(F)(F)F)c2)n1	nan
	162659079	180701	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	392	6	2	5	2.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4762205	180701	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	392	6	2	5	2.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162663893	181424	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(C(F)(F)F)cc2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4780640	181424	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(C(F)(F)F)cc2)ncn1	10.1021/acs.jmedchem.0c01498
	54670455	155258	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	408	4	1	3	5.3	Cc1cc(-c2sc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4059658	155258	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	408	4	1	3	5.3	Cc1cc(-c2sc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653588	184602	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	5	1	4	3.7	CC(=O)c1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4857429	184602	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	5	1	4	3.7	CC(=O)c1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653600	185105	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	CHEMBL4865212	185105	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	137640725	156489	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	444	4	1	3	5.8	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(C(F)(F)F)c1	10.1016/j.bmc.2017.03.064
	CHEMBL4073584	156489	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	444	4	1	3	5.8	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(C(F)(F)F)c1	10.1016/j.bmc.2017.03.064
	162644528	178810	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	443	6	3	6	3.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Nc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4739868	178810	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	443	6	3	6	3.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Nc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162655320	180132	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	410	6	2	5	2.8	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4755625	180132	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	410	6	2	5	2.8	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	122653730	179601	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4749272	179601	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	10.1021/acs.jmedchem.0c01498
	122653687	184953	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4862838	184953	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653670	184933	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4862614	184933	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653730	179601	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4749272	179601	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653499	185484	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)cc(Cl)c2)c1	nan
	CHEMBL4871179	185484	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)cc(Cl)c2)c1	nan
	137654783	158332	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3cccc(Cl)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4095110	158332	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3cccc(Cl)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	162655975	180203	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	458	7	2	6	3.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(OC(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4756386	180203	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	458	7	2	6	3.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(OC(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	155977949	181427	13	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4780654	181427	13	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	137659986	158669	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	390	4	1	3	5.1	Cc1cc(C(N)=O)ccc1-c1sc(Cc2cccc(C(F)(F)F)c2)nc1C	10.1016/j.bmc.2017.03.064
	CHEMBL4098770	158669	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	390	4	1	3	5.1	Cc1cc(C(N)=O)ccc1-c1sc(Cc2cccc(C(F)(F)F)c2)nc1C	10.1016/j.bmc.2017.03.064
	122653605	185929	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	5	3.8	O=C(N[C@@H]1CCOC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4877497	185929	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	5	3.8	O=C(N[C@@H]1CCOC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	69921128	164518	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	Cc1c(C(=O)NCCO)c(CO)nn1-c1cccc2cc(Cc3cccc(C(F)(F)F)c3)sc12	10.1016/j.bmc.2018.02.005
	CHEMBL4226751	164518	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	Cc1c(C(=O)NCCO)c(CO)nn1-c1cccc2cc(Cc3cccc(C(F)(F)F)c3)sc12	10.1016/j.bmc.2018.02.005
	69921041	164667	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	6	2	5	5.0	Cc1nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c(C)c1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	CHEMBL4229063	164667	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	6	2	5	5.0	Cc1nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c(C)c1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	162660100	180646	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)cnn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4761453	180646	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)cnn1	10.1021/acs.jmedchem.0c01498
	162660762	180675	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	6	3.3	O=C(c1cc(F)cc(C(F)(F)F)c1)c1ccnc(N2CCc3c(C(=O)NCCO)cccc32)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4761816	180675	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	6	3.3	O=C(c1cc(F)cc(C(F)(F)F)c1)c1ccnc(N2CCc3c(C(=O)NCCO)cccc32)n1	10.1021/acs.jmedchem.0c01498
	122653655	185794	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	5	1	4	3.7	CC(=O)c1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1	nan
	CHEMBL4875581	185794	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	5	1	4	3.7	CC(=O)c1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1	nan
	137647647	157110	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	352	5	1	4	4.1	COc1cccc(Cc2nc(C)c(-c3ccc(C(N)=O)c(C)c3)s2)c1	10.1016/j.bmc.2017.03.064
	CHEMBL4081439	157110	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	352	5	1	4	4.1	COc1cccc(Cc2nc(C)c(-c3ccc(C(N)=O)c(C)c3)s2)c1	10.1016/j.bmc.2017.03.064
	162652816	179796	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	6	3.3	O=C(c1cc(F)cc(C(F)(F)F)c1)c1cc(N2CCc3c(C(=O)NCCO)cccc32)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4751676	179796	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	6	3.3	O=C(c1cc(F)cc(C(F)(F)F)c1)c1cc(N2CCc3c(C(=O)NCCO)cccc32)ncn1	10.1021/acs.jmedchem.0c01498
	70922254	164513	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	487	7	1	5	5.7	COCCNC(=O)c1c(C)nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1C	10.1016/j.bmc.2018.02.005
	CHEMBL4226695	164513	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	487	7	1	5	5.7	COCCNC(=O)c1c(C)nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1C	10.1016/j.bmc.2018.02.005
	122653422	185373	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	362	4	1	4	3.3	Cc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cnc1F	nan
	CHEMBL4869553	185373	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	362	4	1	4	3.3	Cc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cnc1F	nan
	137635271	155483	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	406	5	1	4	4.8	COc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4062229	155483	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	406	5	1	4	4.8	COc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653459	183828	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	2	4	3.7	CNC(=O)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4846042	183828	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	2	4	3.7	CNC(=O)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653726	185032	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.7	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NC[C@@H](F)CO)c2)cc1F	nan
	CHEMBL4864048	185032	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.7	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NC[C@@H](F)CO)c2)cc1F	nan
	122653449	183966	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	495	7	2	4	3.5	O=C(NCCN1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4848165	183966	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	495	7	2	4	3.5	O=C(NCCN1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	162656501	180313	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1nccc(Cc2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4757616	180313	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1nccc(Cc2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	59193825	111923	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	441	6	2	3	4.6	O=C(NCCO)c1cccc(-c2cccc3c2OC(Cc2cccc(C(F)(F)F)c2)C3)c1	10.1021/jm5002919
	CHEMBL3297807	111923	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	441	6	2	3	4.6	O=C(NCCO)c1cccc(-c2cccc3c2OC(Cc2cccc(C(F)(F)F)c2)C3)c1	10.1021/jm5002919
	69921479	1344	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	10.1016/j.bmc.2018.02.005
	9804	1344	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	10.1016/j.bmc.2018.02.005
	CHEMBL4228912	1344	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	10.1016/j.bmc.2018.02.005
	122653611	184590	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	387	5	1	5	3.4	CC(=O)Oc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4857269	184590	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	387	5	1	5	3.4	CC(=O)Oc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122654148	184510	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4856037	184510	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	137637645	155681	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3ccc(Cl)cc3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4064577	155681	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3ccc(Cl)cc3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653689	184935	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	401	4	1	5	3.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)OCCCO3)ccn1	nan
	CHEMBL4862638	184935	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	401	4	1	5	3.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)OCCCO3)ccn1	nan
	137644761	157945	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	376	4	1	3	4.8	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)cc1	10.1016/j.bmc.2017.03.064
	CHEMBL4091030	157945	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	376	4	1	3	4.8	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)cc1	10.1016/j.bmc.2017.03.064
	122653437	184097	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	404	5	2	4	3.0	CNC(=O)c1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	CHEMBL4849975	184097	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	404	5	2	4	3.0	CNC(=O)c1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	56651044	157601	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	391	4	1	3	4.2	Cc1cc(-c2cc(Cc3cc(F)cc(C(F)(F)F)c3)nn2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4087237	157601	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	391	4	1	3	4.2	Cc1cc(-c2cc(Cc3cc(F)cc(C(F)(F)F)c3)nn2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653604	185499	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	5	1	4	4.4	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(OC(F)(F)F)c2)ccn1	nan
	CHEMBL4871459	185499	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	5	1	4	4.4	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(OC(F)(F)F)c2)ccn1	nan
	122653668	184797	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	463	5	1	5	4.8	Cn1cc(NC(=O)c2cccc3c2CCN3c2cc(Cc3cc(F)c(F)c(F)c3)ccn2)cn1	nan
	CHEMBL4860543	184797	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	463	5	1	5	4.8	Cn1cc(NC(=O)c2cccc3c2CCN3c2cc(Cc3cc(F)c(F)c(F)c3)ccn2)cn1	nan
	162662725	181312	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	444	6	2	6	3.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Oc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4779168	181312	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	444	6	2	6	3.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Oc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	137649487	156659	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	374	4	1	3	4.9	Cc1cc(-c2sc(Cc3cc(F)cc(Cl)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4075971	156659	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	374	4	1	3	4.9	Cc1cc(-c2sc(Cc3cc(F)cc(Cl)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	137639427	156241	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	340	4	1	3	4.3	Cc1cc(-c2sc(Cc3cccc(F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4070849	156241	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	340	4	1	3	4.3	Cc1cc(-c2sc(Cc3cccc(F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	162644756	178862	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	7	2	5	4.0	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4740473	178862	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	7	2	5	4.0	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	44623954	1114	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	10.1021/jm5002919
	8840	1114	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	10.1021/jm5002919
	CHEMBL3299119	1114	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	10.1021/jm5002919
	59193920	111953	5	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	453	7	1	3	6.3	COCCNC(=O)c1cccc(-c2cccc3cc(Cc4cc(F)cc(Cl)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3298233	111953	5	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	453	7	1	3	6.3	COCCNC(=O)c1cccc(-c2cccc3cc(Cc4cc(F)cc(Cl)c4)sc23)c1	10.1021/jm5002919
	122653478	183927	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	495	6	2	4	4.4	O=C(NC[C@H](O)C(F)(F)F)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4847442	183927	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	495	6	2	4	4.4	O=C(NC[C@H](O)C(F)(F)F)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	162665315	181665	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	374	6	2	5	2.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccccc2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4783576	181665	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	374	6	2	5	2.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccccc2)ncn1	10.1021/acs.jmedchem.0c01498
	122653639	184044	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	421	7	2	5	3.2	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)cc1F	nan
	CHEMBL4849417	184044	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	421	7	2	5	3.2	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)cc1F	nan
	122653746	185909	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	6	2	4	3.6	O=C(NCCO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4877187	185909	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	6	2	4	3.6	O=C(NCCO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653653	184150	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	485	9	1	5	4.2	COCC(COC)NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4850677	184150	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	485	9	1	5	4.2	COCC(COC)NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653556	185622	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	469	8	2	5	3.9	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4873066	185622	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	469	8	2	5	3.9	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	162654687	180018	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	478	6	2	5	4.1	O=C(NCCO)c1cccc2c1CCN2c1nccc(C(F)c2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4754435	180018	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	478	6	2	5	4.1	O=C(NCCO)c1cccc2c1CCN2c1nccc(C(F)c2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	162675088	182735	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	478	6	2	5	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(C(F)c2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4797286	182735	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	478	6	2	5	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(C(F)c2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162674993	182789	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	476	6	3	6	3.1	O=C(NCCO)c1cccc2c1CCN2c1cc(C(O)c2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4797830	182789	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	476	6	3	6	3.1	O=C(NCCO)c1cccc2c1CCN2c1cc(C(O)c2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	59193747	112046	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	O=C(NCCO)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)oc23)c1	10.1021/jm5002919
	CHEMBL3299120	112046	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	O=C(NCCO)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)oc23)c1	10.1021/jm5002919
	162655237	180127	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	490	7	3	6	3.0	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4755614	180127	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	490	7	3	6	3.0	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	122653637	185479	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	363	4	2	4	3.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(O)c(F)c2)ccn1	nan
	CHEMBL4871096	185479	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	363	4	2	4	3.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(O)c(F)c2)ccn1	nan
	162672139	182333	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	404	7	2	6	2.5	COc1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	CHEMBL4792434	182333	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	404	7	2	6	2.5	COc1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	122653507	185636	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	450	6	1	4	5.0	N#CCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4873264	185636	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	450	6	1	4	5.0	N#CCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653498	185247	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	2	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(CO)c2)ccn1	nan
	CHEMBL4867455	185247	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	2	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(CO)c2)ccn1	nan
	122653457	184487	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NC[C@H](O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4855685	184487	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NC[C@H](O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	59194084	112048	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	455	6	2	3	5.9	O=C(NCCO)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3299122	112048	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	455	6	2	3	5.9	O=C(NCCO)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	137639301	156413	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	418	5	1	3	6.0	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(C(C)C)c1	10.1016/j.bmc.2017.03.064
	CHEMBL4072782	156413	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	418	5	1	3	6.0	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(C(C)C)c1	10.1016/j.bmc.2017.03.064
	162652119	179763	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	6	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4751311	179763	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	6	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162677433	182929	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4799772	182929	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	122653552	185286	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	386	6	1	4	3.5	CN(C)Cc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4868031	185286	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	386	6	1	4	3.5	CN(C)Cc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	59193882	112047	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	455	6	2	3	5.9	O=C(NCCO)c1cccc(-c2cccc3sc(Cc4cccc(C(F)(F)F)c4)cc23)c1	10.1021/jm5002919
	CHEMBL3299121	112047	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	455	6	2	3	5.9	O=C(NCCO)c1cccc(-c2cccc3sc(Cc4cccc(C(F)(F)F)c4)cc23)c1	10.1021/jm5002919
	122653447	185871	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	369	4	1	4	4.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc3ccccc3o2)ccn1	nan
	CHEMBL4876570	185871	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	369	4	1	4	4.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc3ccccc3o2)ccn1	nan
	59193828	112049	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	4	4.5	O=C(NCCO)c1cccc(-c2cccc3nn(Cc4cccc(C(F)(F)F)c4)cc23)c1	10.1021/jm5002919
	CHEMBL3299123	112049	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	4	4.5	O=C(NCCO)c1cccc(-c2cccc3nn(Cc4cccc(C(F)(F)F)c4)cc23)c1	10.1021/jm5002919
	137648436	157336	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	394	4	1	3	5.0	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(F)c1	10.1016/j.bmc.2017.03.064
	CHEMBL4083957	157336	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	394	4	1	3	5.0	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(F)c1	10.1016/j.bmc.2017.03.064
	137648989	156567	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3ccccc3Cl)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4074656	156567	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3ccccc3Cl)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	162654874	180006	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	488	8	2	5	4.4	O=C(NCCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4754346	180006	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	488	8	2	5	4.4	O=C(NCCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162655610	180155	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	476	6	3	6	3.1	O=C(NCCO)c1cccc2c1CCN2c1nccc(C(O)c2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4755935	180155	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	476	6	3	6	3.1	O=C(NCCO)c1cccc2c1CCN2c1nccc(C(O)c2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	137659770	158736	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	377	4	1	4	4.2	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)cn1	10.1016/j.bmc.2017.03.064
	CHEMBL4099457	158736	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	377	4	1	4	4.2	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)cn1	10.1016/j.bmc.2017.03.064
	67185105	111926	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	469	7	1	3	6.6	COCCNC(=O)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3297811	111926	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	469	7	1	3	6.6	COCCNC(=O)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	122653539	184571	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	4	5.0	NC(=O)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4857044	184571	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	4	5.0	NC(=O)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ccn1	nan
	162647123	178947	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	462	6	1	4	4.6	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4741318	178947	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	462	6	1	4	4.6	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	69921111	164642	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	6	2	5	4.6	Cn1nc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)cc1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	CHEMBL4228734	164642	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	6	2	5	4.6	Cn1nc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)cc1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	162649639	179501	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	7	1	5	4.3	COCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4748048	179501	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	7	1	5	4.3	COCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	69921074	164490	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	6	2	5	4.7	Cc1nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)cc1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	CHEMBL4226295	164490	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	6	2	5	4.7	Cc1nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)cc1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	122653454	183960	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4847995	183960	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653710	184873	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	423	7	1	4	4.2	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCF)cccc43)c2)cc1F	nan
	CHEMBL4861734	184873	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	423	7	1	4	4.2	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCF)cccc43)c2)cc1F	nan
	122653718	184895	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4862064	184895	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	59193981	111925	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	468	6	2	3	5.4	NC(=O)CNC(=O)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3297810	111925	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	468	6	2	3	5.4	NC(=O)CNC(=O)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	122653716	185546	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	501	7	2	5	3.7	O=C(NCC1(CO)COC1)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4871931	185546	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	501	7	2	5	3.7	O=C(NCC1(CO)COC1)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	162668388	182172	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	4.0	O=C(NCCO)c1cccc2c1CCN2c1cc(C(F)c2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4790115	182172	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	4.0	O=C(NCCO)c1cccc2c1CCN2c1cc(C(F)c2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162665062	181496	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	458	6	3	6	3.0	O=C(NCCO)c1cccc2c1CCN2c1cc(C(O)c2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4781520	181496	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	458	6	3	6	3.0	O=C(NCCO)c1cccc2c1CCN2c1cc(C(O)c2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162656735	180268	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	494	6	2	5	4.3	O=C(NCCO)c1cccc2c1CCN2c1nncc(Cc2cc(F)cc(C(F)(F)F)c2)c1Cl	10.1021/acs.jmedchem.0c01498
	CHEMBL4757171	180268	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	494	6	2	5	4.3	O=C(NCCO)c1cccc2c1CCN2c1nncc(Cc2cc(F)cc(C(F)(F)F)c2)c1Cl	10.1021/acs.jmedchem.0c01498
	137661708	158922	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	391	4	1	3	4.3	Cc1cc(-n2cc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4101517	158922	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	391	4	1	3	4.3	Cc1cc(-n2cc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653471	185051	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	8	2	5	3.4	CN(C)CC(O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4864354	185051	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	8	2	5	3.4	CN(C)CC(O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653560	185232	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)n1	nan
	CHEMBL4867123	185232	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)n1	nan
	122653474	185827	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	380	4	1	4	4.0	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc3ccccc3c2)ccn1	nan
	CHEMBL4876029	185827	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	380	4	1	4	4.0	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc3ccccc3c2)ccn1	nan
	122653651	184517	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	366	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(F)c(F)c2)ccn1	nan
	CHEMBL4856067	184517	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	366	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(F)c(F)c2)ccn1	nan
	70922218	164487	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	7	1	5	5.1	COCCNC(=O)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1016/j.bmc.2018.02.005
	CHEMBL4226253	164487	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	7	1	5	5.1	COCCNC(=O)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1016/j.bmc.2018.02.005
	69921013	164517	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	7	1	5	5.4	COCCNC(=O)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1C	10.1016/j.bmc.2018.02.005
	CHEMBL4226750	164517	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	7	1	5	5.4	COCCNC(=O)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1C	10.1016/j.bmc.2018.02.005
	59193856	112050	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	4	4.5	O=C(NCCO)c1cccc(-c2cccc3cn(Cc4cccc(C(F)(F)F)c4)nc23)c1	10.1021/jm5002919
	CHEMBL3299124	112050	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	4	4.5	O=C(NCCO)c1cccc(-c2cccc3cn(Cc4cccc(C(F)(F)F)c4)nc23)c1	10.1021/jm5002919
	59193730	112051	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	441	6	2	3	4.6	O=C(NCCO)c1cccc(-c2cccc3c2CC(Cc2cccc(C(F)(F)F)c2)O3)c1	10.1021/jm5002919
	CHEMBL3299125	112051	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	441	6	2	3	4.6	O=C(NCCO)c1cccc(-c2cccc3c2CC(Cc2cccc(C(F)(F)F)c2)O3)c1	10.1021/jm5002919
	162659255	180650	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	504	8	2	6	3.3	O=C(c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1)N(CCO)CCO	10.1021/acs.jmedchem.0c01498
	CHEMBL4761550	180650	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	504	8	2	6	3.3	O=C(c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1)N(CCO)CCO	10.1021/acs.jmedchem.0c01498
	137653669	158019	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	365	5	1	4	4.2	Cc1cc(-c2sc(Cc3cccc(N(C)C)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4091718	158019	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	365	5	1	4	4.2	Cc1cc(-c2sc(Cc3cccc(N(C)C)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653555	185525	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	411	4	1	3	4.7	CNC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4871721	185525	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	411	4	1	3	4.7	CNC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	162662957	181337	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccccc2C(F)(F)F)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4779620	181337	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccccc2C(F)(F)F)ncn1	10.1021/acs.jmedchem.0c01498
	122653438	184940	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4862739	184940	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	54670452	157044	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	390	4	1	3	5.1	Cc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4080724	157044	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	390	4	1	3	5.1	Cc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	56649300	157229	26	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4082756	157229	26	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	162670049	182124	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	5	4.0	Cc1c(Cc2cc(F)cc(C(F)(F)F)c2)cnnc1N1CCc2c(C(=O)NCCO)cccc21	10.1021/acs.jmedchem.0c01498
	CHEMBL4789517	182124	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	5	4.0	Cc1c(Cc2cc(F)cc(C(F)(F)F)c2)cnnc1N1CCc2c(C(=O)NCCO)cccc21	10.1021/acs.jmedchem.0c01498
	162668520	182051	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	472	4	1	5	3.7	O=C(c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1)N1CC(O)C1	10.1021/acs.jmedchem.0c01498
	CHEMBL4788591	182051	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	472	4	1	5	3.7	O=C(c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1)N1CC(O)C1	10.1021/acs.jmedchem.0c01498
	122653533	185364	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	465	10	2	6	3.3	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCOCCO)cccc43)c2)cc1F	nan
	CHEMBL4869490	185364	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	465	10	2	6	3.3	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCOCCO)cccc43)c2)cc1F	nan
	118798887	185666	17	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	6	2	4	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4873666	185666	17	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	6	2	4	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653606	183928	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	411	4	1	3	4.8	Cc1cc(Cc2cccc(C(F)(F)F)c2)cc(N2CCc3c(C(N)=O)cccc32)n1	nan
	CHEMBL4847476	183928	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	411	4	1	3	4.8	Cc1cc(Cc2cccc(C(F)(F)F)c2)cc(N2CCc3c(C(N)=O)cccc32)n1	nan
	59193906	111924	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	453	6	2	3	5.7	Cc1c(Cc2cccc(C(F)(F)F)c2)oc2c(-c3cccc(C(=O)NCCO)c3)cccc12	10.1021/jm5002919
	CHEMBL3297809	111924	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	453	6	2	3	5.7	Cc1c(Cc2cccc(C(F)(F)F)c2)oc2c(-c3cccc(C(=O)NCCO)c3)cccc12	10.1021/jm5002919
	137660928	158753	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	404	5	1	3	5.4	CCc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4099668	158753	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	404	5	1	3	5.4	CCc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	44816186	111954	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	486	6	2	3	5.5	NC(=O)CNC(=O)c1cccc(-c2ccc(F)c3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3298234	111954	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	486	6	2	3	5.5	NC(=O)CNC(=O)c1cccc(-c2ccc(F)c3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	162647487	179365	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	434	8	2	7	2.5	COc1cc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)cc(OC)c1	10.1021/acs.jmedchem.0c01498
	CHEMBL4746394	179365	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	434	8	2	7	2.5	COc1cc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)cc(OC)c1	10.1021/acs.jmedchem.0c01498
	70922568	164485	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	445	6	2	5	4.4	O=C(NCCO)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1016/j.bmc.2018.02.005
	CHEMBL4226225	164485	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	445	6	2	5	4.4	O=C(NCCO)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1016/j.bmc.2018.02.005
	69921357	164673	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	7	1	5	5.4	COCCNC(=O)c1cn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)nc1C	10.1016/j.bmc.2018.02.005
	CHEMBL4229128	164673	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	7	1	5	5.4	COCCNC(=O)c1cn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)nc1C	10.1016/j.bmc.2018.02.005
	122653711	184834	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	493	7	2	6	4.2	O=C(Nc1cnn(CCO)c1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4861218	184834	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	493	7	2	6	4.2	O=C(Nc1cnn(CCO)c1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653542	185332	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4868910	185332	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	162659193	180640	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	388	6	2	5	2.8	Cc1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	CHEMBL4761381	180640	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	388	6	2	5	2.8	Cc1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	56649300	157229	26	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Affinity Phenotypic Cellular interaction (Alphascreen (cAMP increase in human GPR52 expressed CHO cell line)) EUB0000317b GPR52Affinity Phenotypic Cellular interaction (Alphascreen (cAMP increase in human GPR52 expressed CHO cell line)) EUB0000317b GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	nan
	CHEMBL4082756	157229	26	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Affinity Phenotypic Cellular interaction (Alphascreen (cAMP increase in human GPR52 expressed CHO cell line)) EUB0000317b GPR52Affinity Phenotypic Cellular interaction (Alphascreen (cAMP increase in human GPR52 expressed CHO cell line)) EUB0000317b GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	nan
	162645603	178930	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	402	6	2	5	3.1	Cc1cc(C)cc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	CHEMBL4741200	178930	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	402	6	2	5	3.1	Cc1cc(C)cc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	122653404	185697	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	461	6	2	5	4.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Oc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4874102	185697	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	461	6	2	5	4.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Oc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	162671742	182223	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1cccnc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4790746	182223	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1cccnc1	10.1021/acs.jmedchem.0c01133
	162664350	181587	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	240	5	0	3	2.8	Cn1nccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4782590	181587	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	240	5	0	3	2.8	Cn1nccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162646497	178938	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1ccccc1-c1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4741257	178938	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1ccccc1-c1ccccc1	10.1021/acs.jmedchem.0c01133
	162676088	182741	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1cccc(C(=O)/C=C/CCc2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4797370	182741	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1cccc(C(=O)/C=C/CCc2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	162669764	181986	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	226	5	0	2	3.7	O=C(/C=C/CCc1ccccc1)c1ccoc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4787771	181986	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	226	5	0	2	3.7	O=C(/C=C/CCc1ccccc1)c1ccoc1	10.1021/acs.jmedchem.0c01133
	162648761	179373	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	314	5	0	1	4.8	O=C(/C=C/CCc1ccccc1Br)c1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4746541	179373	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	314	5	0	1	4.8	O=C(/C=C/CCc1ccccc1Br)c1ccccc1	10.1021/acs.jmedchem.0c01133
	162670773	182399	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1ccccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4793323	182399	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1ccccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162673688	182574	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	254	5	0	1	4.2	O=C(/C=C/CCc1ccccc1)c1ccccc1F	10.1021/acs.jmedchem.0c01133
	CHEMBL4795327	182574	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	254	5	0	1	4.2	O=C(/C=C/CCc1ccccc1)c1ccccc1F	10.1021/acs.jmedchem.0c01133
	162659243	180624	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	314	5	0	1	4.8	O=C(/C=C/CCc1ccc(Br)cc1)c1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4761208	180624	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	314	5	0	1	4.8	O=C(/C=C/CCc1ccc(Br)cc1)c1ccccc1	10.1021/acs.jmedchem.0c01133
	162672248	182288	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1ccncc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4791780	182288	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1ccncc1	10.1021/acs.jmedchem.0c01133
	162649157	179260	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1ccccn1	10.1021/acs.jmedchem.0c01133
	CHEMBL4745132	179260	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1ccccn1	10.1021/acs.jmedchem.0c01133
	162664011	181623	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	254	5	0	1	4.2	O=C(/C=C/CCc1ccccc1)c1cccc(F)c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4783011	181623	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	254	5	0	1	4.2	O=C(/C=C/CCc1ccccc1)c1cccc(F)c1	10.1021/acs.jmedchem.0c01133
	162659388	180608	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1cccc(C(=O)/C=C/CCc2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4761078	180608	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1cccc(C(=O)/C=C/CCc2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	162648653	179328	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1ccccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4746014	179328	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1ccccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162661330	180818	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	264	5	0	1	4.7	Cc1cccc(C)c1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4763588	180818	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	264	5	0	1	4.7	Cc1cccc(C)c1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162644983	178880	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1ccc(C(=O)/C=C/CCc2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4740701	178880	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1ccc(C(=O)/C=C/CCc2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	162650192	179562	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	286	5	0	1	5.2	O=C(/C=C/CCc1ccccc1)c1cccc2ccccc12	10.1021/acs.jmedchem.0c01133
	CHEMBL4748854	179562	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	286	5	0	1	5.2	O=C(/C=C/CCc1ccccc1)c1cccc2ccccc12	10.1021/acs.jmedchem.0c01133
	58517179	181193	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	286	5	0	1	5.2	O=C(/C=C/CCc1ccccc1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4777734	181193	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	286	5	0	1	5.2	O=C(/C=C/CCc1ccccc1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.0c01133
	162660152	180754	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1ccc(C(=O)/C=C/CCc2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4762863	180754	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1ccc(C(=O)/C=C/CCc2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	5316932	91113	23	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	264	7	0	1	4.4	O=C(/C=C/CCc1ccccc1)CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL240484	91113	23	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	264	7	0	1	4.4	O=C(/C=C/CCc1ccccc1)CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162662933	181432	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	226	5	0	2	3.7	O=C(/C=C/CCc1ccccc1)c1ccco1	10.1021/acs.jmedchem.0c01133
	CHEMBL4780703	181432	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	226	5	0	2	3.7	O=C(/C=C/CCc1ccccc1)c1ccco1	10.1021/acs.jmedchem.0c01133
	10879121	89193	16	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	236	5	0	1	4.1	O=C(/C=C/CCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL2375494	89193	16	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	236	5	0	1	4.1	O=C(/C=C/CCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01133
	162675641	182814	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4798117	182814	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	162656078	180105	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4755423	180105	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	156588927	181566	13	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1cccs1	10.1021/acs.jmedchem.0c01133
	CHEMBL4782344	181566	13	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1cccs1	10.1021/acs.jmedchem.0c01133
	162675368	182711	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1ccsc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4796964	182711	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1ccsc1	10.1021/acs.jmedchem.0c01133
	44623954	1114	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	24884590
	8840	1114	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	24884590
	CHEMBL3299119	1114	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	24884590
	69921479	1344	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	29478803
	9804	1344	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	29478803
	CHEMBL4228912	1344	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	29478803

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	90645439	112045	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin)	ChEMBL	414	8	2	4	3.9	O=C(NCCO)c1cccc(-c2cccc(OCCc3cc(F)cc(Cl)c3)n2)c1	10.1021/jm5002919
	CHEMBL3299118	112045	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin)	ChEMBL	414	8	2	4	3.9	O=C(NCCO)c1cccc(-c2cccc(OCCc3cc(F)cc(Cl)c3)n2)c1	10.1021/jm5002919
	44206579	112044	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin)	ChEMBL	430	8	2	4	4.1	O=C(NCCO)c1cccc(-c2cccc(OCCc3cccc(C(F)(F)F)c3)n2)c1	10.1021/jm5002919
	CHEMBL3299117	112044	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin)	ChEMBL	430	8	2	4	4.1	O=C(NCCO)c1cccc(-c2cccc(OCCc3cccc(C(F)(F)F)c3)n2)c1	10.1021/jm5002919
	56649300	157229	26	None	-	0	Mouse	7.2	pEC50	=	7.2	Binding	Agonist activity at mouse GPR52Agonist activity at mouse GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4082756	157229	26	None	-	0	Mouse	7.2	pEC50	=	7.2	Binding	Agonist activity at mouse GPR52Agonist activity at mouse GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	56649300	157229	26	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	nan
	CHEMBL4082756	157229	26	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	nan

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Main reference

Ligand source activities (1 row/activity)