GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

Get vendors

Show entries

Search:

Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	72943279	185533	None	0	Human	Functional	pEC50	=	10.9	10.9	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	425	3	2	4	5.5	Cc1cc(C)cc(-c2cncc(-c3nc4cc(C)cc(C)c4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	CHEMBL4861425	185533	None	0	Human	Functional	pEC50	=	10.9	10.9	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	425	3	2	4	5.5	Cc1cc(C)cc(-c2cncc(-c3nc4cc(C)cc(C)c4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	164624123	185861	None	0	Human	Functional	pEC50	=	10.9	10.9	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	415	3	2	4	5.0	Cc1cc(C)cc(-c2cncc(-c3nc4cc(F)ccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	CHEMBL4866325	185861	None	0	Human	Functional	pEC50	=	10.9	10.9	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	415	3	2	4	5.0	Cc1cc(C)cc(-c2cncc(-c3nc4cc(F)ccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	164623072	186281	None	0	Human	Functional	pEC50	=	10.9	10.9	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	411	3	2	4	5.1	Cc1cc(C)cc(-c2cncc(-c3nc4cc(C)ccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	CHEMBL4872591	186281	None	0	Human	Functional	pEC50	=	10.9	10.9	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	411	3	2	4	5.1	Cc1cc(C)cc(-c2cncc(-c3nc4cc(C)ccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	164610567	184779	None	0	Human	Functional	pEC50	=	10.9	10.9	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	465	3	2	4	5.9	Cc1cc(C)cc(-c2cncc(-c3nc4cc(C(F)(F)F)ccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	CHEMBL4849848	184779	None	0	Human	Functional	pEC50	=	10.9	10.9	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	465	3	2	4	5.9	Cc1cc(C)cc(-c2cncc(-c3nc4cc(C(F)(F)F)ccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	164614320	185492	None	0	Human	Functional	pEC50	=	10.8	10.8	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	431	3	2	4	5.5	Cc1cc(C)cc(-c2cncc(-c3nc4cc(Cl)ccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	CHEMBL4860633	185492	None	0	Human	Functional	pEC50	=	10.8	10.8	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	431	3	2	4	5.5	Cc1cc(C)cc(-c2cncc(-c3nc4cc(Cl)ccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	118057812	186326	None	0	Human	Functional	pEC50	=	10.8	10.8	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	431	4	2	5	4.7	COc1cc(F)cc(-c2cncc(-c3nc4cc(C)ccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	CHEMBL4873269	186326	None	0	Human	Functional	pEC50	=	10.8	10.8	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	431	4	2	5	4.7	COc1cc(F)cc(-c2cncc(-c3nc4cc(C)ccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	118057816	185018	None	0	Human	Functional	pEC50	=	10.7	10.7	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	419	3	2	4	4.8	Cc1cc(F)cc(-c2cncc(-c3nc4cc(F)ccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	CHEMBL4853282	185018	None	0	Human	Functional	pEC50	=	10.7	10.7	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	419	3	2	4	4.8	Cc1cc(F)cc(-c2cncc(-c3nc4cc(F)ccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	164615920	185381	None	0	Human	Functional	pEC50	=	10.6	10.6	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	422	3	2	5	4.7	Cc1cc(C)cc(-c2cncc(-c3nc4cc(C#N)ccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	CHEMBL4858892	185381	None	0	Human	Functional	pEC50	=	10.6	10.6	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	422	3	2	5	4.7	Cc1cc(C)cc(-c2cncc(-c3nc4cc(C#N)ccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	2055	2907	None	39	Human	Functional	pEC50	=	10.5	10.5	8	5	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL		None	None	None		None	10.1016/j.bmc.2021.116424
	383414	2907	None	39	Human	Functional	pEC50	=	10.5	10.5	8	5	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL		None	None	None		None	10.1016/j.bmc.2021.116424
	448601	2907	None	39	Human	Functional	pEC50	=	10.5	10.5	8	5	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL		None	None	None		None	10.1016/j.bmc.2021.116424
	448601.0	2907	None	39	Human	Functional	pEC50	=	10.5	10.5	8	5	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL		None	None	None		None	10.1016/j.bmc.2021.116424
	90488715	2907	None	39	Human	Functional	pEC50	=	10.5	10.5	8	5	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL		None	None	None		None	10.1016/j.bmc.2021.116424
	CHEMBL1680	2907	None	39	Human	Functional	pEC50	=	10.5	10.5	8	5	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL		None	None	None		None	10.1016/j.bmc.2021.116424
	CHEMBL262746	2907	None	39	Human	Functional	pEC50	=	10.5	10.5	8	5	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL		None	None	None		None	10.1016/j.bmc.2021.116424
	DB00104	2907	None	39	Human	Functional	pEC50	=	10.5	10.5	8	5	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL		None	None	None		None	10.1016/j.bmc.2021.116424
	72943278	185710	None	0	Human	Functional	pEC50	=	10.5	10.5	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	428	4	2	4	5.2	Cc1cc(C)cc(NC(=O)c2cncc(-c3cc(C)cc(C)c3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	CHEMBL4863880	185710	None	0	Human	Functional	pEC50	=	10.5	10.5	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	428	4	2	4	5.2	Cc1cc(C)cc(NC(=O)c2cncc(-c3cc(C)cc(C)c3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	118057665	184507	None	0	Human	Functional	pEC50	=	10.4	10.4	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	428	4	2	4	5.2	Cc1cc(C)cc(C(=O)Nc2cncc(-c3cc(C)cc(C)c3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	CHEMBL4845867	184507	None	0	Human	Functional	pEC50	=	10.4	10.4	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	428	4	2	4	5.2	Cc1cc(C)cc(C(=O)Nc2cncc(-c3cc(C)cc(C)c3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	164624692	186152	None	0	Human	Functional	pEC50	=	10.4	10.4	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	458	4	2	6	4.3	Cc1cc(C(=O)Nc2cncc(-c3cc(Cl)cc(Cl)c3)c2N2CCC(N)CC2)n(C)n1	10.1016/j.bmc.2021.116424
	CHEMBL4870834	186152	None	0	Human	Functional	pEC50	=	10.4	10.4	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	458	4	2	6	4.3	Cc1cc(C(=O)Nc2cncc(-c3cc(Cl)cc(Cl)c3)c2N2CCC(N)CC2)n(C)n1	10.1016/j.bmc.2021.116424
	164622117	185590	None	0	Human	Functional	pEC50	=	10.3	10.3	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	443	5	2	6	4.5	COc1cc(OC)cc(-c2cncc(-c3nc4cc(C)ccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	CHEMBL4862195	185590	None	0	Human	Functional	pEC50	=	10.3	10.3	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	443	5	2	6	4.5	COc1cc(OC)cc(-c2cncc(-c3nc4cc(C)ccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	118057675	186534	None	0	Human	Functional	pEC50	=	10.1	10.1	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	435	4	2	5	4.5	COc1cc(F)cc(-c2cncc(-c3nc4cc(F)ccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	CHEMBL4876263	186534	None	0	Human	Functional	pEC50	=	10.1	10.1	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	435	4	2	5	4.5	COc1cc(F)cc(-c2cncc(-c3nc4cc(F)ccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	118057538	184932	None	0	Human	Functional	pEC50	=	10.1	10.1	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	397	3	2	4	4.8	Cc1cc(C)cc(-c2cncc(-c3nc4ccccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	CHEMBL4851978	184932	None	0	Human	Functional	pEC50	=	10.1	10.1	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	397	3	2	4	4.8	Cc1cc(C)cc(-c2cncc(-c3nc4ccccc4[nH]3)c2N2CCC(N)CC2)c1	10.1016/j.bmc.2021.116424
	164627529	186713	None	0	Human	Functional	pEC50	=	10.1	10.1	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	439	3	2	4	5.2	NC1CCN(c2c(-c3cc(F)cc(Cl)c3)cncc2-c2nc3cc(F)ccc3[nH]2)CC1	10.1016/j.bmc.2021.116424
	CHEMBL4878917	186713	None	0	Human	Functional	pEC50	=	10.1	10.1	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	439	3	2	4	5.2	NC1CCN(c2c(-c3cc(F)cc(Cl)c3)cncc2-c2nc3cc(F)ccc3[nH]2)CC1	10.1016/j.bmc.2021.116424
	164614581	185107	None	0	Human	Functional	pEC50	=	10	10.0	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	512	4	2	6	5.0	Cn1ncc(C(=O)Nc2cncc(-c3cc(Cl)cc(Cl)c3)c2N2CCC(N)CC2)c1C(F)(F)F	10.1016/j.bmc.2021.116424
	CHEMBL4854548	185107	None	0	Human	Functional	pEC50	=	10	10.0	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	512	4	2	6	5.0	Cn1ncc(C(=O)Nc2cncc(-c3cc(Cl)cc(Cl)c3)c2N2CCC(N)CC2)c1C(F)(F)F	10.1016/j.bmc.2021.116424
	16129706	211490	None	36	Human	Functional	pEC50	=	10	10.0	-4	12	Inhibition of forskolin-induced cAMP accumulation in CHO-K1 cells expressing human sst2 receptorInhibition of forskolin-induced cAMP accumulation in CHO-K1 cells expressing human sst2 receptor	ChEMBL		None	None	None		C[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O	10.1016/j.bmcl.2005.05.061
	CHEMBL1823872	211490	None	36	Human	Functional	pEC50	=	10	10.0	-4	12	Inhibition of forskolin-induced cAMP accumulation in CHO-K1 cells expressing human sst2 receptorInhibition of forskolin-induced cAMP accumulation in CHO-K1 cells expressing human sst2 receptor	ChEMBL		None	None	None		C[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O	10.1016/j.bmcl.2005.05.061
	162666722	182352	None	0	Human	Functional	pEC50	=	10.0	10.0	-2	2	Agonist activity at human SST2 expressed in CHO-K1 cells assessed as reduction in NKH477-induced intracellular cAMP accumulationAgonist activity at human SST2 expressed in CHO-K1 cells assessed as reduction in NKH477-induced intracellular cAMP accumulation	ChEMBL	520	5	2	5	5.9	Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cccc(F)c4O)cc3C2C(=O)N(C)CC2CCCN2)c1	10.1016/j.bmcl.2020.127391
	CHEMBL4783565	182352	None	0	Human	Functional	pEC50	=	10.0	10.0	-2	2	Agonist activity at human SST2 expressed in CHO-K1 cells assessed as reduction in NKH477-induced intracellular cAMP accumulationAgonist activity at human SST2 expressed in CHO-K1 cells assessed as reduction in NKH477-induced intracellular cAMP accumulation	ChEMBL	520	5	2	5	5.9	Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cccc(F)c4O)cc3C2C(=O)N(C)CC2CCCN2)c1	10.1016/j.bmcl.2020.127391
	140762567	180383	None	0	Human	Functional	pEC50	=	9.9	9.9	64	3	Agonist activity at human SST2 expressed in CHO-K1 cells assessed as reduction in NKH477-induced intracellular cAMP accumulationAgonist activity at human SST2 expressed in CHO-K1 cells assessed as reduction in NKH477-induced intracellular cAMP accumulation	ChEMBL	520	5	2	5	5.9	Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(O)cc(F)c4)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1	10.1016/j.bmcl.2020.127391
	CHEMBL4750691	180383	None	0	Human	Functional	pEC50	=	9.9	9.9	64	3	Agonist activity at human SST2 expressed in CHO-K1 cells assessed as reduction in NKH477-induced intracellular cAMP accumulationAgonist activity at human SST2 expressed in CHO-K1 cells assessed as reduction in NKH477-induced intracellular cAMP accumulation	ChEMBL	520	5	2	5	5.9	Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(O)cc(F)c4)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1	10.1016/j.bmcl.2020.127391
	164624443	185611	None	0	Human	Functional	pEC50	=	9.9	9.9	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	458	4	2	6	4.3	Cc1nn(C)cc1C(=O)Nc1cncc(-c2cc(Cl)cc(Cl)c2)c1N1CCC(N)CC1	10.1016/j.bmc.2021.116424
	CHEMBL4862497	185611	None	0	Human	Functional	pEC50	=	9.9	9.9	-	1	Agonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP AssayAgonist activity at human SSTR2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by GloSensor cAMP Assay	ChEMBL	458	4	2	6	4.3	Cc1nn(C)cc1C(=O)Nc1cncc(-c2cc(Cl)cc(Cl)c2)c1N1CCC(N)CC1	10.1016/j.bmc.2021.116424
	140762567	180383	None	0	Human	Functional	pEC50	=	9.9	9.9	64	3	Agonist activity at human SST2 expressed in CHO-K1 cells assessed as reduction in NKH477-induced intracellular cAMP accumulationAgonist activity at human SST2 expressed in CHO-K1 cells assessed as reduction in NKH477-induced intracellular cAMP accumulation	ChEMBL	520	5	2	5	5.9	Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(O)cc(F)c4)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1	10.1016/j.bmcl.2020.127391
	CHEMBL4750691	180383	None	0	Human	Functional	pEC50	=	9.9	9.9	64	3	Agonist activity at human SST2 expressed in CHO-K1 cells assessed as reduction in NKH477-induced intracellular cAMP accumulationAgonist activity at human SST2 expressed in CHO-K1 cells assessed as reduction in NKH477-induced intracellular cAMP accumulation	ChEMBL	520	5	2	5	5.9	Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(O)cc(F)c4)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1	10.1016/j.bmcl.2020.127391

Showing 1 to 50 of 452 entries

Previous1 2 3 4 5…10Next

Get vendors

Show entries

Search:

Ligands (move mouse cursor over ligand name to see structure)					Receptor		Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found		Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found

Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name No matches found	GPCRdb ID No matches found	Reference ligand No matches found	Vendors	Species No matches found	Assay Type No matches found	Activity Type No matches found	Activity Relation No matches found	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description No matches found	Source No matches found	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles No matches found	DOI No matches found
	171347244	194435	None	0	Human	Binding	pEC50	=	9.9	9.9	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	468	4	2	6	5.2	COc1cc(F)cc(-c2cnc3ccc(-c4cccc(C#N)c4O)cc3c2N2CCC(N)CC2)c1	10.1021/acsmedchemlett.2c00431
	CHEMBL5286005	194435	None	0	Human	Binding	pEC50	=	9.9	9.9	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	468	4	2	6	5.2	COc1cc(F)cc(-c2cnc3ccc(-c4cccc(C#N)c4O)cc3c2N2CCC(N)CC2)c1	10.1021/acsmedchemlett.2c00431
	140762567	180383	None	0	Human	Binding	pEC50	=	9.9	9.9	-	0	Agonist activity at SST2 (unknown origin)Agonist activity at SST2 (unknown origin)	ChEMBL	520	5	2	5	5.9	Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(O)cc(F)c4)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1	10.1016/j.bmcl.2020.127391
	CHEMBL4750691	180383	None	0	Human	Binding	pEC50	=	9.9	9.9	-	0	Agonist activity at SST2 (unknown origin)Agonist activity at SST2 (unknown origin)	ChEMBL	520	5	2	5	5.9	Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(O)cc(F)c4)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1	10.1016/j.bmcl.2020.127391
	171347244	194435	None	0	Human	Binding	pEC50	=	9.9	9.9	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	468	4	2	6	5.2	COc1cc(F)cc(-c2cnc3ccc(-c4cccc(C#N)c4O)cc3c2N2CCC(N)CC2)c1	10.1021/acsmedchemlett.2c00431
	CHEMBL5286005	194435	None	0	Human	Binding	pEC50	=	9.9	9.9	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	468	4	2	6	5.2	COc1cc(F)cc(-c2cnc3ccc(-c4cccc(C#N)c4O)cc3c2N2CCC(N)CC2)c1	10.1021/acsmedchemlett.2c00431
	171352686	194129	None	0	Human	Binding	pEC50	=	9.9	9.9	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	458	4	2	4	4.9	NC(=O)c1cccc(-c2ccc3ncc(-c4cc(F)cc(F)c4)c(N4CCC(N)CC4)c3c2)c1	10.1021/acsmedchemlett.2c00431
	CHEMBL5279239	194129	None	0	Human	Binding	pEC50	=	9.9	9.9	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	458	4	2	4	4.9	NC(=O)c1cccc(-c2ccc3ncc(-c4cc(F)cc(F)c4)c(N4CCC(N)CC4)c3c2)c1	10.1021/acsmedchemlett.2c00431
	140762568	181370	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at SST2 (unknown origin)Agonist activity at SST2 (unknown origin)	ChEMBL	547	6	2	5	5.3	Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(F)cc(C(N)=O)c4)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1	10.1016/j.bmcl.2020.127391
	CHEMBL4761949	181370	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at SST2 (unknown origin)Agonist activity at SST2 (unknown origin)	ChEMBL	547	6	2	5	5.3	Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(F)cc(C(N)=O)c4)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1	10.1016/j.bmcl.2020.127391
	171352686	194129	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	458	4	2	4	4.9	NC(=O)c1cccc(-c2ccc3ncc(-c4cc(F)cc(F)c4)c(N4CCC(N)CC4)c3c2)c1	10.1021/acsmedchemlett.2c00431
	CHEMBL5279239	194129	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	458	4	2	4	4.9	NC(=O)c1cccc(-c2ccc3ncc(-c4cc(F)cc(F)c4)c(N4CCC(N)CC4)c3c2)c1	10.1021/acsmedchemlett.2c00431
	171357026	194155	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	449	3	2	4	5.6	NC1CCN(c2c(-c3cc(F)cc(F)c3)cnc3ccc(-c4cccc(F)c4O)cc23)CC1	10.1021/acsmedchemlett.2c00431
	CHEMBL5279994	194155	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	449	3	2	4	5.6	NC1CCN(c2c(-c3cc(F)cc(F)c3)cnc3ccc(-c4cccc(F)c4O)cc23)CC1	10.1021/acsmedchemlett.2c00431
	171349150	194317	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	431	3	2	4	5.5	NC1CCN(c2c(-c3cc(F)cc(F)c3)cnc3ccc(-c4cccc(O)c4)cc23)CC1	10.1021/acsmedchemlett.2c00431
	CHEMBL5283444	194317	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	431	3	2	4	5.5	NC1CCN(c2c(-c3cc(F)cc(F)c3)cnc3ccc(-c4cccc(O)c4)cc23)CC1	10.1021/acsmedchemlett.2c00431
	140837181	194468	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	452	3	2	5	5.5	Cc1cc(F)cc(-c2cnc3ccc(-c4cccc(C#N)c4O)cc3c2N2CCC(N)CC2)c1	10.1021/acsmedchemlett.2c00431
	CHEMBL5286879	194468	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	452	3	2	5	5.5	Cc1cc(F)cc(-c2cnc3ccc(-c4cccc(C#N)c4O)cc3c2N2CCC(N)CC2)c1	10.1021/acsmedchemlett.2c00431
	171349150	194317	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	431	3	2	4	5.5	NC1CCN(c2c(-c3cc(F)cc(F)c3)cnc3ccc(-c4cccc(O)c4)cc23)CC1	10.1021/acsmedchemlett.2c00431
	CHEMBL5283444	194317	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	431	3	2	4	5.5	NC1CCN(c2c(-c3cc(F)cc(F)c3)cnc3ccc(-c4cccc(O)c4)cc23)CC1	10.1021/acsmedchemlett.2c00431
	171357026	194155	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	449	3	2	4	5.6	NC1CCN(c2c(-c3cc(F)cc(F)c3)cnc3ccc(-c4cccc(F)c4O)cc23)CC1	10.1021/acsmedchemlett.2c00431
	CHEMBL5279994	194155	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	449	3	2	4	5.6	NC1CCN(c2c(-c3cc(F)cc(F)c3)cnc3ccc(-c4cccc(F)c4O)cc23)CC1	10.1021/acsmedchemlett.2c00431
	140837181	194468	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	452	3	2	5	5.5	Cc1cc(F)cc(-c2cnc3ccc(-c4cccc(C#N)c4O)cc3c2N2CCC(N)CC2)c1	10.1021/acsmedchemlett.2c00431
	CHEMBL5286879	194468	None	0	Human	Binding	pEC50	=	9.8	9.8	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	452	3	2	5	5.5	Cc1cc(F)cc(-c2cnc3ccc(-c4cccc(C#N)c4O)cc3c2N2CCC(N)CC2)c1	10.1021/acsmedchemlett.2c00431
	140762573	182483	None	0	Human	Binding	pEC50	=	9.7	9.7	-	0	Agonist activity at SST2 (unknown origin)Agonist activity at SST2 (unknown origin)	ChEMBL	520	5	2	5	5.9	Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(O)ccc4F)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1	10.1016/j.bmcl.2020.127391
	CHEMBL4785112	182483	None	0	Human	Binding	pEC50	=	9.7	9.7	-	0	Agonist activity at SST2 (unknown origin)Agonist activity at SST2 (unknown origin)	ChEMBL	520	5	2	5	5.9	Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(O)ccc4F)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1	10.1016/j.bmcl.2020.127391
	134168328	193648	None	22	Human	Binding	pEC50	=	9.6	9.6	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	456	3	2	5	5.4	N#Cc1cccc(-c2ccc3ncc(-c4cc(F)cc(F)c4)c(N4CCC(N)CC4)c3c2)c1O	10.1021/acsmedchemlett.2c00431
	134168328.0	193648	None	22	Human	Binding	pEC50	=	9.6	9.6	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	456	3	2	5	5.4	N#Cc1cccc(-c2ccc3ncc(-c4cc(F)cc(F)c4)c(N4CCC(N)CC4)c3c2)c1O	10.1021/acsmedchemlett.2c00431
	CHEMBL4594359	193648	None	22	Human	Binding	pEC50	=	9.6	9.6	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	456	3	2	5	5.4	N#Cc1cccc(-c2ccc3ncc(-c4cc(F)cc(F)c4)c(N4CCC(N)CC4)c3c2)c1O	10.1021/acsmedchemlett.2c00431
	CHEMBL5267842	193648	None	22	Human	Binding	pEC50	=	9.6	9.6	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	456	3	2	5	5.4	N#Cc1cccc(-c2ccc3ncc(-c4cc(F)cc(F)c4)c(N4CCC(N)CC4)c3c2)c1O	10.1021/acsmedchemlett.2c00431
	134168328	193648	None	22	Human	Binding	pEC50	=	9.6	9.6	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	456	3	2	5	5.4	N#Cc1cccc(-c2ccc3ncc(-c4cc(F)cc(F)c4)c(N4CCC(N)CC4)c3c2)c1O	10.1021/acsmedchemlett.2c00431
	134168328.0	193648	None	22	Human	Binding	pEC50	=	9.6	9.6	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	456	3	2	5	5.4	N#Cc1cccc(-c2ccc3ncc(-c4cc(F)cc(F)c4)c(N4CCC(N)CC4)c3c2)c1O	10.1021/acsmedchemlett.2c00431
	CHEMBL4594359	193648	None	22	Human	Binding	pEC50	=	9.6	9.6	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	456	3	2	5	5.4	N#Cc1cccc(-c2ccc3ncc(-c4cc(F)cc(F)c4)c(N4CCC(N)CC4)c3c2)c1O	10.1021/acsmedchemlett.2c00431
	CHEMBL5267842	193648	None	22	Human	Binding	pEC50	=	9.6	9.6	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	456	3	2	5	5.4	N#Cc1cccc(-c2ccc3ncc(-c4cc(F)cc(F)c4)c(N4CCC(N)CC4)c3c2)c1O	10.1021/acsmedchemlett.2c00431
	166992296	193855	None	0	Human	Binding	pEC50	=	9.5	9.5	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	438	3	2	5	5.2	N#Cc1cccc(-c2ccc3ncc(-c4cccc(F)c4)c(N4CCC(N)CC4)c3c2)c1O	10.1021/acsmedchemlett.2c00431
	CHEMBL5273084	193855	None	0	Human	Binding	pEC50	=	9.5	9.5	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	438	3	2	5	5.2	N#Cc1cccc(-c2ccc3ncc(-c4cccc(F)c4)c(N4CCC(N)CC4)c3c2)c1O	10.1021/acsmedchemlett.2c00431
	166992296	193855	None	0	Human	Binding	pEC50	=	9.5	9.5	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	438	3	2	5	5.2	N#Cc1cccc(-c2ccc3ncc(-c4cccc(F)c4)c(N4CCC(N)CC4)c3c2)c1O	10.1021/acsmedchemlett.2c00431
	CHEMBL5273084	193855	None	0	Human	Binding	pEC50	=	9.5	9.5	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	438	3	2	5	5.2	N#Cc1cccc(-c2ccc3ncc(-c4cccc(F)c4)c(N4CCC(N)CC4)c3c2)c1O	10.1021/acsmedchemlett.2c00431
	140836905	194015	None	0	Human	Binding	pEC50	=	9.5	9.5	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	474	3	2	5	5.5	N#Cc1cc(F)cc(-c2ccc3ncc(-c4cc(F)cc(F)c4)c(N4CCC(N)CC4)c3c2)c1O	10.1021/acsmedchemlett.2c00431
	CHEMBL5276605	194015	None	0	Human	Binding	pEC50	=	9.5	9.5	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	474	3	2	5	5.5	N#Cc1cc(F)cc(-c2ccc3ncc(-c4cc(F)cc(F)c4)c(N4CCC(N)CC4)c3c2)c1O	10.1021/acsmedchemlett.2c00431
	140836905	194015	None	0	Human	Binding	pEC50	=	9.5	9.5	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	474	3	2	5	5.5	N#Cc1cc(F)cc(-c2ccc3ncc(-c4cc(F)cc(F)c4)c(N4CCC(N)CC4)c3c2)c1O	10.1021/acsmedchemlett.2c00431
	CHEMBL5276605	194015	None	0	Human	Binding	pEC50	=	9.5	9.5	-	0	Agonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST2 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay	ChEMBL	474	3	2	5	5.5	N#Cc1cc(F)cc(-c2ccc3ncc(-c4cc(F)cc(F)c4)c(N4CCC(N)CC4)c3c2)c1O	10.1021/acsmedchemlett.2c00431
	162666722	182352	None	0	Rat	Binding	pEC50	=	9.3	9.3	-	0	Agonist activity at rat SST2Agonist activity at rat SST2	ChEMBL	520	5	2	5	5.9	Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cccc(F)c4O)cc3C2C(=O)N(C)CC2CCCN2)c1	10.1016/j.bmcl.2020.127391
	CHEMBL4783565	182352	None	0	Rat	Binding	pEC50	=	9.3	9.3	-	0	Agonist activity at rat SST2Agonist activity at rat SST2	ChEMBL	520	5	2	5	5.9	Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cccc(F)c4O)cc3C2C(=O)N(C)CC2CCCN2)c1	10.1016/j.bmcl.2020.127391
	162648021	180079	None	0	Human	Binding	pEC50	=	9.1	9.1	-	0	Agonist activity at SST2 (unknown origin)Agonist activity at SST2 (unknown origin)	ChEMBL	520	5	2	5	5.9	Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cccc(F)c4O)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1	10.1016/j.bmcl.2020.127391
	CHEMBL4746816	180079	None	0	Human	Binding	pEC50	=	9.1	9.1	-	0	Agonist activity at SST2 (unknown origin)Agonist activity at SST2 (unknown origin)	ChEMBL	520	5	2	5	5.9	Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cccc(F)c4O)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1	10.1016/j.bmcl.2020.127391
	155544425	173486	None	0	Human	Binding	pEC50	=	9	9.0	436	5	Binding affinity to human SSTR2 expressed in CHO-K1 cells assessed as induction of SSTR2 internalization after 4 hrs by chemiluminescent assayBinding affinity to human SSTR2 expressed in CHO-K1 cells assessed as induction of SSTR2 internalization after 4 hrs by chemiluminescent assay	ChEMBL	1785	27	15	26	3.3	COc1cc2cc(c1Cl)N(C)C(=O)C[C@H](OC(=O)[C@H](C)N(C)C(=O)CCSSC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](N)Cc3ccccc3)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(N)=O)[C@@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C/C=C(\C)C2	10.1021/acs.jmedchem.8b02036
	CHEMBL4527856	173486	None	0	Human	Binding	pEC50	=	9	9.0	436	5	Binding affinity to human SSTR2 expressed in CHO-K1 cells assessed as induction of SSTR2 internalization after 4 hrs by chemiluminescent assayBinding affinity to human SSTR2 expressed in CHO-K1 cells assessed as induction of SSTR2 internalization after 4 hrs by chemiluminescent assay	ChEMBL	1785	27	15	26	3.3	COc1cc2cc(c1Cl)N(C)C(=O)C[C@H](OC(=O)[C@H](C)N(C)C(=O)CCSSC[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](N)Cc3ccccc3)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(N)=O)[C@@]1(C)O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@H](OC)/C=C/C=C(\C)C2	10.1021/acs.jmedchem.8b02036
	118753685	120683	None	0	Human	Binding	pEC50	=	9	9.0	-	0	Relative effective concentration against human somatostatin receptor type 2 expressed in CHO cells; (n=3)Relative effective concentration against human somatostatin receptor type 2 expressed in CHO cells; (n=3)	ChEMBL	1160	17	14	15	-0.5	C[C@@H](O)[C@H](CO)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2ccc(O)c(I)c2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1	10.1021/jm040794i
	CHEMBL3144288	120683	None	0	Human	Binding	pEC50	=	9	9.0	-	0	Relative effective concentration against human somatostatin receptor type 2 expressed in CHO cells; (n=3)Relative effective concentration against human somatostatin receptor type 2 expressed in CHO cells; (n=3)	ChEMBL	1160	17	14	15	-0.5	C[C@@H](O)[C@H](CO)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2ccc(O)c(I)c2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1	10.1021/jm040794i

Showing 1 to 50 of 2,448 entries

Previous1 2 3 4 5…49Next

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)