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Ligand source activities (1 row/activity)

Affinity
Potency

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

[D-Phe⁶,β-Ala¹¹,Phe¹³,Nle¹⁴]bombesin-(6-14)	1478	None	0	Human	Binding	pKi	=	-	8.75	-1	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10454496
[D-Phe⁶,β-Ala¹¹,Phe¹³,Nle¹⁴]bombesin-(6-14)	1478	None	0	Human	Binding	pKi	=	-	8.75	-1	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/21729729
[Leu⁸]-phyllolitorin	2307	None	0	Rat	Binding	pKi	>	-	5.00	-23	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9325344
[Leu⁸]-phyllolitorin	2307	None	0	Rat	Binding	pKi	>	-	5.00	-23	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10353842
[Phe¹³]bombesin	3102	None	0	Rat	Binding	pKi	=	-	7.34	-58	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10454496
[Phe¹³]bombesin	3102	None	0	Rat	Binding	pKi	=	-	7.34	-58	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9325344
[Phe¹³]bombesin	3102	None	0	Rat	Binding	pKi	=	-	7.34	-58	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10353842
bag-1	569	None	23	Human	Binding	IC50	=	7000.00	5.16	-	5	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human NMB-R expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	333.2	7	1	2	5.24	CCC(C)(C)Cc1cnc(CCc2ccc(-c3ccccn3)cc2)[nH]1	https://dx.doi.org/10.1016/j.bmcl.2010.02.076
bombesin	704	None	34	Human	Binding	pKi	=	-	7.48	-7	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10454496
bombesin	704	None	34	Human	Binding	pKi	=	-	7.48	-7	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/7838118
bombesin	704	None	34	Human	Binding	Ki	=	2.00	8.70	-7	6	Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1016/0960-894X(96)00481-7
bombesin	704	None	34	Rat	Binding	pKi	=	-	7.57	-24	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10454496
bombesin	704	None	34	Rat	Binding	pKi	=	-	7.57	-24	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/7838118
CHEMBL100065	4172	None	0	Human	Binding	IC50	=	790.00	6.10	-	1	Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells	ChEMBL	633.4	8	4	3	8.75	Cc1ccc2[nH]c3c(c2c1)C(C)C(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3	https://dx.doi.org/10.1016/j.bmcl.2004.04.045
CHEMBL100065	4172	None	0	Human	Binding	IC50	=	700.00	6.16	-	1	Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells	ChEMBL	633.4	8	4	3	8.75	Cc1ccc2[nH]c3c(c2c1)C(C)C(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3	https://dx.doi.org/10.1016/j.bmcl.2004.04.045
CHEMBL101026	4343	None	0	Human	Binding	IC50	=	660.00	6.18	-	1	Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells	ChEMBL	619.4	8	4	3	8.19	Cc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3	https://dx.doi.org/10.1016/j.bmcl.2004.04.045
CHEMBL102647	4590	None	0	Human	Binding	IC50	=	2140.00	5.67	-	1	Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells	ChEMBL	683.3	8	4	3	8.64	CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3cc(Br)ccc3c2C1	https://dx.doi.org/10.1016/j.bmcl.2004.04.045
CHEMBL103430	4697	None	0	Human	Binding	IC50	=	3660.00	5.44	-	1	Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells	ChEMBL	673.4	8	4	3	8.90	CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3cccc(C(F)(F)F)c3c2C1	https://dx.doi.org/10.1016/j.bmcl.2004.04.045
CHEMBL103439	4699	None	0	Human	Binding	IC50	=	620.00	6.21	-	1	Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells	ChEMBL	580.3	7	4	5	5.85	Cc1cc([N+](=O)[O-])ccc1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1	https://dx.doi.org/10.1016/j.bmcl.2004.04.045
CHEMBL103440	4700	None	0	Human	Binding	IC50	=	800.00	6.10	-	1	Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells	ChEMBL	566.3	7	4	5	5.54	O=C(Nc1ccc([N+](=O)[O-])cc1)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1	https://dx.doi.org/10.1016/j.bmcl.2004.04.045

Showing 1 to 20 of 183 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

[D-Phe⁶, Leu¹³, Cpa¹⁴,ψ13-14]bombesin-(6-14)	1481	None	0	Human	Functional	pIC50	>	-	5.00	-7762	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/19463875
[D-Phe⁶,β-Ala¹¹,Phe¹³,Nle¹⁴]bombesin-(6-14)	1478	None	0	Human	Functional	pIC50	=	-	9.59	-4	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/21729729
[Leu⁸]-phyllolitorin	2307	None	0	Human	Functional	pIC50	=	-	6.52	-2	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	-
[Leu⁸]-phyllolitorin	2307	None	0	Rat	Functional	pIC50	=	-	6.84	-1	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/21729729
bantag-1	573	None	0	Human	Functional	pIC50	=	-	5.24	-3388	5	Unclassified	Guide to Pharmacology	894.6	23	7	8	4.76	CC(C)C[C@H](NC(=O)C[C@H](O)[C@H](CC1CCCCC1)NC(O)[C@H](Cc1c[nH]c[nH+]1)N(C)C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C(=O)NCC1=CCCC(C[N+](C)(C)C)=C1	https://pubmed.ncbi.nlm.nih.gov/20096642
bantag-1	573	None	0	Human	Functional	pIC50	=	-	5.24	-3388	5	Unclassified	Guide to Pharmacology	894.6	23	7	8	4.76	CC(C)C[C@H](NC(=O)C[C@H](O)[C@H](CC1CCCCC1)NC(O)[C@H](Cc1c[nH]c[nH+]1)N(C)C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C(=O)NCC1=CCCC(C[N+](C)(C)C)=C1	https://pubmed.ncbi.nlm.nih.gov/23892571
bombesin	704	None	34	Human	Functional	Ki	=	2.00	8.70	-6	6	Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1016/s0960-894x(98)00462-4
bombesin	704	None	34	Human	Functional	pIC50	=	-	8.59	-6	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/21729729
CHEMBL103756	4747	None	0	Human	Functional	EC50	=	1970.00	5.71	-	1	Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate	ChEMBL	635.4	9	4	4	7.89	COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3	https://dx.doi.org/10.1016/j.bmcl.2004.04.045
CHEMBL103756	4747	None	0	Human	Functional	EC50	=	132.00	6.88	-	1	Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate	ChEMBL	635.4	9	4	4	7.89	COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3	https://dx.doi.org/10.1016/j.bmcl.2004.04.045
CHEMBL103756	4747	None	0	Human	Functional	EC50	=	17.70	7.75	-	1	Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate	ChEMBL	635.4	9	4	4	7.89	COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3	https://dx.doi.org/10.1016/j.bmcl.2004.04.045
CHEMBL262992	96612	None	0	Human	Functional	EC50	=	310.00	6.51	-3	3	Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay	ChEMBL	1105.6	31	11	12	2.10	CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)O	https://dx.doi.org/10.1021/jm0210921
CHEMBL312926	106007	None	0	Human	Functional	Ki	=	0.46	9.34	-	2	Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells	ChEMBL	583.3	10	4	5	6.23	COc1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1	https://dx.doi.org/10.1016/s0960-894x(98)00462-4
CHEMBL313030	106028	None	0	Human	Functional	Ki	=	1.50	8.82	-	2	Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells	ChEMBL	595.3	10	4	4	7.34	CC(C)c1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1	https://dx.doi.org/10.1016/s0960-894x(98)00462-4
CHEMBL313346	106122	None	0	Human	Functional	Ki	=	0.97	9.01	-	2	Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells	ChEMBL	554.3	9	4	5	5.61	C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1cccc([N+](=O)[O-])c1)C(=O)NCC1(c2ccccn2)CCCCC1	https://dx.doi.org/10.1016/s0960-894x(98)00462-4
CHEMBL314375	213639	None	0	Human	Functional	Ki	=	2.10	8.68	-	2	Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells	ChEMBL	-	-	-	-	-	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(C)C)C(N)=O	https://dx.doi.org/10.1016/s0960-894x(98)00462-4
CHEMBL3144498	106842	None	0	Human	Functional	EC50	=	18500.00	4.73	-13	3	Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay	ChEMBL	587.2	14	5	4	3.20	NC(=O)CC[C@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	https://dx.doi.org/10.1021/jm0210921
CHEMBL3144503	106847	None	0	Human	Functional	EC50	=	15000.00	4.82	-12	3	Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay	ChEMBL	553.3	14	5	4	2.55	NC(=O)CC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	https://dx.doi.org/10.1021/jm0210921
CHEMBL316085	107181	None	0	Human	Functional	Ki	=	2.80	8.55	-	2	Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells	ChEMBL	543.2	8	4	3	6.36	C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(Cl)cc1)C(=O)NCC1(c2ccccn2)CCCCC1	https://dx.doi.org/10.1016/s0960-894x(98)00462-4
CHEMBL318548	107551	None	0	Human	Functional	EC50	=	603.00	6.22	-	1	Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate	ChEMBL	605.4	8	4	3	7.88	CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1	https://dx.doi.org/10.1016/j.bmcl.2004.04.045

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Ligand source activities (1 row/activity)