Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
CHEMBL525577 213877 0 None -9 3 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at recombinant neuromedin B receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant neuromedin B receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O 10.1016/j.bmcl.2008.09.033
CHEMBL403317 210783 21 None -169 4 Human 6.9 pEC50 = 6.9 Functional
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assayEffective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CN)[C@@H](C)O)C(N)=O 10.1021/jm0210921
44333515 4677 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphateAgonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
CHEMBL103756 4677 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphateAgonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
90663970 106308 0 None -12 3 Human 4.8 pEC50 = 4.8 Functional
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assayEffective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
ChEMBL 553 14 5 4 2.5 NC(=O)CC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1021/jm0210921
CHEMBL3144503 106308 0 None -12 3 Human 4.8 pEC50 = 4.8 Functional
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assayEffective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
ChEMBL 553 14 5 4 2.5 NC(=O)CC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1021/jm0210921
44333515 4677 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphateAgonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
CHEMBL103756 4677 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphateAgonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
90663965 106303 0 None -13 3 Human 4.7 pEC50 = 4.7 Functional
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assayEffective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
ChEMBL 587 14 5 4 3.2 NC(=O)CC[C@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1021/jm0210921
CHEMBL3144498 106303 0 None -13 3 Human 4.7 pEC50 = 4.7 Functional
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assayEffective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
ChEMBL 587 14 5 4 3.2 NC(=O)CC[C@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1021/jm0210921
44333515 4677 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphateAgonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
CHEMBL103756 4677 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphateAgonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
44300286 96111 0 None -3 3 Human 6.5 pEC50 = 6.5 Functional
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assayEffective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
ChEMBL 1106 31 11 12 2.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)O 10.1021/jm0210921
CHEMBL262992 96111 0 None -3 3 Human 6.5 pEC50 = 6.5 Functional
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assayEffective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
ChEMBL 1106 31 11 12 2.1 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)O 10.1021/jm0210921
CHEMBL438926 212063 15 None -93 3 Human 5.5 pEC50 = 5.5 Functional
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assayEffective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(C)C)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm0210921
44334117 107009 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphateAgonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
ChEMBL 605 8 4 3 7.9 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL318548 107009 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphateAgonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
ChEMBL 605 8 4 3 7.9 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
3622597 193744 11 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human neuromedin B receptor transfected in HEK293 cells assessed as inhibition of 1 nM neuromedin B-induced myo-[3H]inositol phosphate accumulation after 60 mins by scintillation proximity assayAntagonist activity at human neuromedin B receptor transfected in HEK293 cells assessed as inhibition of 1 nM neuromedin B-induced myo-[3H]inositol phosphate accumulation after 60 mins by scintillation proximity assay
ChEMBL 384 1 2 3 6.0 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL552189 193744 11 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human neuromedin B receptor transfected in HEK293 cells assessed as inhibition of 1 nM neuromedin B-induced myo-[3H]inositol phosphate accumulation after 60 mins by scintillation proximity assayAntagonist activity at human neuromedin B receptor transfected in HEK293 cells assessed as inhibition of 1 nM neuromedin B-induced myo-[3H]inositol phosphate accumulation after 60 mins by scintillation proximity assay
ChEMBL 384 1 2 3 6.0 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
44250209 194812 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human neuromedin B receptor transfected in HEK293 cells assessed as inhibition of 1 nM neuromedin B-induced myo-[3H]inositol phosphate accumulation after 60 mins by scintillation proximity assayAntagonist activity at human neuromedin B receptor transfected in HEK293 cells assessed as inhibition of 1 nM neuromedin B-induced myo-[3H]inositol phosphate accumulation after 60 mins by scintillation proximity assay
ChEMBL 426 1 2 3 6.8 Cc1ccc2c(c1)NC(c1ccccc1C(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL563374 194812 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human neuromedin B receptor transfected in HEK293 cells assessed as inhibition of 1 nM neuromedin B-induced myo-[3H]inositol phosphate accumulation after 60 mins by scintillation proximity assayAntagonist activity at human neuromedin B receptor transfected in HEK293 cells assessed as inhibition of 1 nM neuromedin B-induced myo-[3H]inositol phosphate accumulation after 60 mins by scintillation proximity assay
ChEMBL 426 1 2 3 6.8 Cc1ccc2c(c1)NC(c1ccccc1C(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL403317 210783 21 None -169 4 Human 10.2 pKi = 10.2 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CN)[C@@H](C)O)C(N)=O 10.1016/s0960-894x(98)00462-4
621 2986 24 None 117 3 Human 9.8 pKi = 9.8 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 10.1016/s0960-894x(98)00462-4
9937534 2986 24 None 117 3 Human 9.8 pKi = 9.8 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 10.1016/s0960-894x(98)00462-4
CHEMBL329650 2986 24 None 117 3 Human 9.8 pKi = 9.8 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 10.1016/s0960-894x(98)00462-4
626 2987 35 None 125 2 Human 9.8 pKi = 9.8 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 584 10 4 6 5.6 COc1ccc(nc1)C1(CCCCC1)CNC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)Nc1ccc(cc1)[N+](=O)[O-])C 10.1016/s0960-894x(98)00462-4
9829828 2987 35 None 125 2 Human 9.8 pKi = 9.8 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 584 10 4 6 5.6 COc1ccc(nc1)C1(CCCCC1)CNC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)Nc1ccc(cc1)[N+](=O)[O-])C 10.1016/s0960-894x(98)00462-4
CHEMBL405908 2987 35 None 125 2 Human 9.8 pKi = 9.8 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 584 10 4 6 5.6 COc1ccc(nc1)C1(CCCCC1)CNC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)Nc1ccc(cc1)[N+](=O)[O-])C 10.1016/s0960-894x(98)00462-4
44321212 110940 0 None - 0 Human 9.5 pKi = 9.5 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 598 10 4 6 6.1 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)NCC1(c2ccc([N+](=O)[O-])cc2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL327388 110940 0 None - 0 Human 9.5 pKi = 9.5 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 598 10 4 6 6.1 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)NCC1(c2ccc([N+](=O)[O-])cc2)CCCCC1 10.1016/s0960-894x(98)00462-4
44321034 111025 0 None - 0 Human 9.5 pKi = 9.5 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 534 8 4 4 5.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(C#N)cc1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL327840 111025 0 None - 0 Human 9.5 pKi = 9.5 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 534 8 4 4 5.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(C#N)cc1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
44321211 204459 0 None - 0 Human 9.4 pKi = 9.4 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 553 9 4 4 6.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)NCC1(c2ccccc2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL86370 204459 0 None - 0 Human 9.4 pKi = 9.4 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 553 9 4 4 6.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)NCC1(c2ccccc2)CCCCC1 10.1016/s0960-894x(98)00462-4
44321244 204341 0 None - 0 Human 9.4 pKi = 9.4 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 613 11 4 6 6.2 COc1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1OC 10.1016/s0960-894x(98)00462-4
CHEMBL85400 204341 0 None - 0 Human 9.4 pKi = 9.4 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 613 11 4 6 6.2 COc1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1OC 10.1016/s0960-894x(98)00462-4
44321006 105471 0 None - 0 Human 9.3 pKi = 9.3 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 583 10 4 5 6.2 COc1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
CHEMBL312926 105471 0 None - 0 Human 9.3 pKi = 9.3 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 583 10 4 5 6.2 COc1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
44321039 167600 0 None - 0 Human 9.3 pKi = 9.3 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 596 10 4 5 6.3 CN(C)c1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
CHEMBL433143 167600 0 None - 0 Human 9.3 pKi = 9.3 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 596 10 4 5 6.3 CN(C)c1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
44321245 204332 0 None - 0 Human 9.2 pKi = 9.2 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 597 11 4 5 6.6 CCOc1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
CHEMBL85291 204332 0 None - 0 Human 9.2 pKi = 9.2 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 597 11 4 5 6.6 CCOc1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
44321158 204689 0 None - 0 Human 9.2 pKi = 9.2 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 569 9 5 5 5.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)NCC1(c2ccc(O)cc2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL87846 204689 0 None - 0 Human 9.2 pKi = 9.2 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 569 9 5 5 5.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)NCC1(c2ccc(O)cc2)CCCCC1 10.1016/s0960-894x(98)00462-4
44321246 105586 0 None - 0 Human 9.0 pKi = 9.0 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 554 9 4 5 5.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1cccc([N+](=O)[O-])c1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL313346 105586 0 None - 0 Human 9.0 pKi = 9.0 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 554 9 4 5 5.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1cccc([N+](=O)[O-])c1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
44321117 105492 0 None - 0 Human 8.8 pKi = 8.8 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 595 10 4 4 7.3 CC(C)c1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
CHEMBL313030 105492 0 None - 0 Human 8.8 pKi = 8.8 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 595 10 4 4 7.3 CC(C)c1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
44321035 204988 0 None - 0 Human 6.7 pKi = 6.7 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 554 9 4 5 5.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL89813 204988 0 None - 0 Human 6.7 pKi = 6.7 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 554 9 4 5 5.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
101835328 696 35 None -6 3 Human 8.7 pKi = 8.7 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00462-4
16133800 696 35 None -6 3 Human 8.7 pKi = 8.7 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00462-4
16201612 696 35 None -6 3 Human 8.7 pKi = 8.7 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00462-4
616 696 35 None -6 3 Human 8.7 pKi = 8.7 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00462-4
91898967 696 35 None -6 3 Human 8.7 pKi = 8.7 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00462-4
CHEMBL437027 696 35 None -6 3 Human 8.7 pKi = 8.7 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00462-4
DB11724 696 35 None -6 3 Human 8.7 pKi = 8.7 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00462-4
44321083 110990 0 None - 0 Human 8.7 pKi = 8.7 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 577 8 4 3 7.0 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(Cl)c(Cl)c1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL327678 110990 0 None - 0 Human 8.7 pKi = 8.7 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 577 8 4 3 7.0 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(Cl)c(Cl)c1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL314375 209434 0 None - 0 Human 8.7 pKi = 8.7 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(C)C)C(N)=O 10.1016/s0960-894x(98)00462-4
44321084 106641 0 None - 0 Human 8.6 pKi = 8.6 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 543 8 4 3 6.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(Cl)cc1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL316085 106641 0 None - 0 Human 8.6 pKi = 8.6 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 543 8 4 3 6.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(Cl)cc1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
44321037 205126 0 None - 0 Human 8.5 pKi = 8.5 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 577 8 4 3 6.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(C(F)(F)F)cc1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL90614 205126 0 None - 0 Human 8.5 pKi = 8.5 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 577 8 4 3 6.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(C(F)(F)F)cc1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
44321085 204580 0 None - 0 Human 7.6 pKi = 7.6 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 509 8 4 3 5.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccccc1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL87079 204580 0 None - 0 Human 7.6 pKi = 7.6 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 509 8 4 3 5.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccccc1)C(=O)NCC1(c2ccccn2)CCCCC1 10.1016/s0960-894x(98)00462-4
44321036 204979 0 None - 0 Human 8.5 pKi = 8.5 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 583 10 4 5 6.2 COc1ccccc1C1(CNC(=O)[C@](C)(Cc2c[nH]c3ccccc23)NC(=O)Nc2ccc([N+](=O)[O-])cc2)CCCCC1 10.1016/s0960-894x(98)00462-4
CHEMBL89734 204979 0 None - 0 Human 8.5 pKi = 8.5 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 583 10 4 5 6.2 COc1ccccc1C1(CNC(=O)[C@](C)(Cc2c[nH]c3ccccc23)NC(=O)Nc2ccc([N+](=O)[O-])cc2)CCCCC1 10.1016/s0960-894x(98)00462-4
5311352 2984 5 None -2 2 Human 8.2 pKi = 8.2 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/s0960-894x(98)00462-4
620 2984 5 None -2 2 Human 8.2 pKi = 8.2 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/s0960-894x(98)00462-4
CHEMBL86828 2984 5 None -2 2 Human 8.2 pKi = 8.2 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/s0960-894x(98)00462-4
612 1745 0 None - 1 Human 8.0 pKi = 8.0 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00462-4
CHEMBL413196 1745 0 None - 1 Human 8.0 pKi = 8.0 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL None None None None 10.1016/s0960-894x(98)00462-4
44321157 204714 0 None - 0 Human 8.0 pKi = 8.0 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 551 9 4 3 6.8 CC(C)c1ccc(NC(=O)N[C@@](C)(Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
CHEMBL88010 204714 0 None - 0 Human 8.0 pKi = 8.0 Functional
Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsAntagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells
ChEMBL 551 9 4 3 6.8 CC(C)c1ccc(NC(=O)N[C@@](C)(Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/s0960-894x(98)00462-4
6176 567 0 None -3388 5 Human 5.2 pIC50 = 5.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 895 23 7 8 4.8 CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C 20096642
6176 567 0 None -3388 5 Human 5.2 pIC50 = 5.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 895 23 7 8 4.8 CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C 23892571
73755180 567 0 None -3388 5 Human 5.2 pIC50 = 5.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 895 23 7 8 4.8 CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C 20096642
73755180 567 0 None -3388 5 Human 5.2 pIC50 = 5.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 895 23 7 8 4.8 CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C 23892571
3889 2100 0 None -3311 2 Rat 5.8 pIC50 = 5.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11463790
635 1422 0 None -2 4 Rat 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7901752
6172 1423 0 None 10 2 Human 6.3 pIC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19463875
635 1422 0 None 2 4 Human 6.4 pIC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19463875
155817490 2275 0 None -2 4 Human 6.5 pIC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None None
6168 2275 0 None -2 4 Human 6.5 pIC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None None
155817491 1748 0 None -1288 3 Rat 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
6175 1748 0 None -1288 3 Rat 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
155817490 2275 0 None -1 4 Rat 6.8 pIC50 = 6.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
6168 2275 0 None -1 4 Rat 6.8 pIC50 = 6.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
155817491 1748 0 None -758 3 Human 6.9 pIC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
6175 1748 0 None -758 3 Human 6.9 pIC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
621 2986 24 None -117 3 Rat 7.4 pIC50 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 10454496
9937534 2986 24 None -117 3 Rat 7.4 pIC50 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 10454496
CHEMBL329650 2986 24 None -117 3 Rat 7.4 pIC50 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 10454496
155817489 3066 0 None -8 4 Rat 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
6166 3066 0 None -8 4 Rat 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
22146595 3238 0 None -2 3 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
618 3238 0 None -2 3 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
101835328 696 35 None -6 3 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
16133800 696 35 None -6 3 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
16201612 696 35 None -6 3 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
616 696 35 None -6 3 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
91898967 696 35 None -6 3 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
CHEMBL437027 696 35 None -6 3 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
DB11724 696 35 None -6 3 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
155817489 3066 0 None 8 4 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
6166 3066 0 None 8 4 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
155817488 3275 0 None -4 4 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
57340152 3275 0 None -4 4 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
6165 3275 0 None -4 4 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
621 2986 24 None 117 3 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 19463875
9937534 2986 24 None 117 3 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 19463875
CHEMBL329650 2986 24 None 117 3 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 554 9 4 5 5.6 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] 19463875
626 2987 35 None 125 2 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 584 10 4 6 5.6 COc1ccc(nc1)C1(CCCCC1)CNC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)Nc1ccc(cc1)[N+](=O)[O-])C 19463875
9829828 2987 35 None 125 2 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 584 10 4 6 5.6 COc1ccc(nc1)C1(CCCCC1)CNC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)Nc1ccc(cc1)[N+](=O)[O-])C 19463875
CHEMBL405908 2987 35 None 125 2 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 584 10 4 6 5.6 COc1ccc(nc1)C1(CCCCC1)CNC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)Nc1ccc(cc1)[N+](=O)[O-])C 19463875
632 1450 0 None -4 2 Human 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
6163 2728 0 None 67 2 Human 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
155817488 3275 0 None 4 4 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
57340152 3275 0 None 4 4 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
6165 3275 0 None 4 4 Human 9.7 pIC50 = 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
3840 1453 0 None -7762 2 Human 5.0 pIC50 > 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19463875
624 2099 0 None -7943 2 Rat 5.0 pIC50 > 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11463790
49871766 2520 32 None -6165 5 Human 5.0 pIC50 > 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 444 6 2 4 4.5 FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F 21036912
49871766 2520 32 None -6165 5 Human 5.0 pIC50 > 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 444 6 2 4 4.5 FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F 23892571
6170 2520 32 None -6165 5 Human 5.0 pIC50 > 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 444 6 2 4 4.5 FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F 21036912
6170 2520 32 None -6165 5 Human 5.0 pIC50 > 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 444 6 2 4 4.5 FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F 23892571
CHEMBL1672354 2520 32 None -6165 5 Human 5.0 pIC50 > 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 444 6 2 4 4.5 FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F 21036912
CHEMBL1672354 2520 32 None -6165 5 Human 5.0 pIC50 > 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 444 6 2 4 4.5 FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F 23892571


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
117745230 142000 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1523 40 17 21 -3.0 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)O)C(N)=O nan
CHEMBL3890803 142000 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1523 40 17 21 -3.0 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)O)C(N)=O nan
CHEMBL3944194 210727 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(N)=O nan
134145000 149755 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1501 43 16 22 -3.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NCc1ccc(C(=O)C(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
CHEMBL3952732 149755 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1501 43 16 22 -3.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NCc1ccc(C(=O)C(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
134156977 153446 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1604 43 17 21 -2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CC[C@H](CNC(=O)[C@H]2CC[C@H](CNC(=O)CN3CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC3)CC2)CC1)C(C)C)C(N)=O nan
CHEMBL3983862 153446 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1604 43 17 21 -2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CC[C@H](CNC(=O)[C@H]2CC[C@H](CNC(=O)CN3CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC3)CC2)CC1)C(C)C)C(N)=O nan
626 2987 35 None 5 2 Human 9.2 pIC50 = 9.2 Binding
Antagonistic activity against labelled Bombesin receptor bb1 binding sites in rat olfactory bulb by using [125I]- [Tyr] bombesin in presence of [D-Phe-6] bombesin(6-13)ethyl ester; 0.31-1.3Antagonistic activity against labelled Bombesin receptor bb1 binding sites in rat olfactory bulb by using [125I]- [Tyr] bombesin in presence of [D-Phe-6] bombesin(6-13)ethyl ester; 0.31-1.3
ChEMBL 584 10 4 6 5.6 COc1ccc(nc1)C1(CCCCC1)CNC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)Nc1ccc(cc1)[N+](=O)[O-])C 10.1016/s0960-894x(98)00462-4
9829828 2987 35 None 5 2 Human 9.2 pIC50 = 9.2 Binding
Antagonistic activity against labelled Bombesin receptor bb1 binding sites in rat olfactory bulb by using [125I]- [Tyr] bombesin in presence of [D-Phe-6] bombesin(6-13)ethyl ester; 0.31-1.3Antagonistic activity against labelled Bombesin receptor bb1 binding sites in rat olfactory bulb by using [125I]- [Tyr] bombesin in presence of [D-Phe-6] bombesin(6-13)ethyl ester; 0.31-1.3
ChEMBL 584 10 4 6 5.6 COc1ccc(nc1)C1(CCCCC1)CNC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)Nc1ccc(cc1)[N+](=O)[O-])C 10.1016/s0960-894x(98)00462-4
CHEMBL405908 2987 35 None 5 2 Human 9.2 pIC50 = 9.2 Binding
Antagonistic activity against labelled Bombesin receptor bb1 binding sites in rat olfactory bulb by using [125I]- [Tyr] bombesin in presence of [D-Phe-6] bombesin(6-13)ethyl ester; 0.31-1.3Antagonistic activity against labelled Bombesin receptor bb1 binding sites in rat olfactory bulb by using [125I]- [Tyr] bombesin in presence of [D-Phe-6] bombesin(6-13)ethyl ester; 0.31-1.3
ChEMBL 584 10 4 6 5.6 COc1ccc(nc1)C1(CCCCC1)CNC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)Nc1ccc(cc1)[N+](=O)[O-])C 10.1016/s0960-894x(98)00462-4
CHEMBL403317 210783 21 None - 2 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CN)[C@@H](C)O)C(N)=O nan
117745218 149592 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1536 41 17 21 -3.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)c(Cl)c1)C(C)C)C(N)=O nan
CHEMBL3951222 149592 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1536 41 17 21 -3.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)c(Cl)c1)C(C)C)C(N)=O nan
117745209 152368 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1516 42 17 21 -4.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(C(=O)NCCNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
CHEMBL3974709 152368 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1516 42 17 21 -4.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(C(=O)NCCNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
11389266 161256 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of tachykinin receptor 3 expressed in human ileal carcinoid cellsInhibition of tachykinin receptor 3 expressed in human ileal carcinoid cells
ChEMBL 1303 44 17 18 -2.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCC(=O)Nc1ccc(CC(CNCCN)CNCCN)cc1)C(C)C)C(N)=O 10.1021/jm049437y
CHEMBL414307 161256 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of tachykinin receptor 3 expressed in human ileal carcinoid cellsInhibition of tachykinin receptor 3 expressed in human ileal carcinoid cells
ChEMBL 1303 44 17 18 -2.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCC(=O)Nc1ccc(CC(CNCCN)CNCCN)cc1)C(C)C)C(N)=O 10.1021/jm049437y
CHEMBL413893 211351 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of tachykinin receptor 3 expressed in human ileal carcinoid cellsInhibition of tachykinin receptor 3 expressed in human ileal carcinoid cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(N)=O 10.1021/jm049437y
117745205 149897 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1502 41 17 21 -3.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)c1ccc(NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
CHEMBL3953912 149897 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1502 41 17 21 -3.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)c1ccc(NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
87217693 150741 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1489 41 16 21 -3.2 COc1cc(C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)ccc1CNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 nan
CHEMBL3960359 150741 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1489 41 16 21 -3.2 COc1cc(C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)ccc1CNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 nan
134153902 152023 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1592 42 17 21 -1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(-c2ccc(NC(=O)CNC(=O)CN3CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC3)cc2C)cc1)C(C)C)C(N)=O nan
CHEMBL3971676 152023 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1592 42 17 21 -1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(-c2ccc(NC(=O)CNC(=O)CN3CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC3)cc2C)cc1)C(C)C)C(N)=O nan
87217854 143714 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1516 41 16 21 -3.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(N(C)C(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
CHEMBL3904706 143714 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1516 41 16 21 -3.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(N(C)C(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
16154477 149841 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1502 41 17 21 -3.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
CHEMBL3953323 149841 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1502 41 17 21 -3.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
87217796 148415 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1502 41 17 21 -3.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1cccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)c1)C(C)C)C(N)=O nan
CHEMBL3941990 148415 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1502 41 17 21 -3.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1cccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)c1)C(C)C)C(N)=O nan
CHEMBL2371725 208373 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of tachykinin receptor 3 expressed in human ileal carcinoid cellsInhibition of tachykinin receptor 3 expressed in human ileal carcinoid cells
ChEMBL None None None CSCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C(CNCCN)CNCCN)C(C)C)C(N)=O 10.1021/jm049437y
134131431 141843 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1583 40 15 23 -3.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)Cn1c(=O)n(C2CCN(C(=O)CN3CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC3)CC2)c2ccccc21)C(C)C)C(N)=O nan
CHEMBL3889538 141843 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1583 40 15 23 -3.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)Cn1c(=O)n(C2CCN(C(=O)CN3CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC3)CC2)c2ccccc21)C(C)C)C(N)=O nan
87217644 143185 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1489 42 16 21 -3.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(OCCNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
CHEMBL3900523 143185 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1489 42 16 21 -3.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(OCCNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
134154031 152324 0 None - 0 Rat 8.0 pIC50 = 8.0 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1517 48 21 23 -8.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
CHEMBL3974250 152324 0 None - 0 Rat 8.0 pIC50 = 8.0 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1517 48 21 23 -8.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
44333639 4659 0 None - 0 Human 5.0 pIC50 = 5 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 526 7 4 5 4.6 CC(C)(CNC(=O)C1(NC(=O)Nc2ccc([N+](=O)[O-])cc2)CCc2[nH]c3ccccc3c2C1)c1ccccn1 10.1016/j.bmcl.2004.04.045
CHEMBL103594 4659 0 None - 0 Human 5.0 pIC50 = 5 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 526 7 4 5 4.6 CC(C)(CNC(=O)C1(NC(=O)Nc2ccc([N+](=O)[O-])cc2)CCc2[nH]c3ccccc3c2C1)c1ccccn1 10.1016/j.bmcl.2004.04.045
45271538 193642 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 398 1 1 3 6.0 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2C 10.1016/j.bmcl.2009.05.124
CHEMBL551511 193642 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 398 1 1 3 6.0 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2C 10.1016/j.bmcl.2009.05.124
45273304 194231 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 386 1 3 4 5.4 CC1(C)CC(=O)C2=C(C1)Nc1ccc(O)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
CHEMBL559093 194231 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 386 1 3 4 5.4 CC1(C)CC(=O)C2=C(C1)Nc1ccc(O)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
45273305 194803 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 413 2 3 4 4.8 CC1(C)CC(=O)C2=C(C1)Nc1ccc(C(N)=O)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
CHEMBL563295 194803 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 413 2 3 4 4.8 CC1(C)CC(=O)C2=C(C1)Nc1ccc(C(N)=O)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
45272454 194840 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 342 1 2 3 5.0 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CCC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL563540 194840 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 342 1 2 3 5.0 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CCC1=O)N2 10.1016/j.bmcl.2009.05.124
45267289 194853 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 414 2 3 4 5.4 CC1(C)CC(=O)C2=C(C1)Nc1ccc(C(=O)O)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
CHEMBL563633 194853 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 414 2 3 4 5.4 CC1(C)CC(=O)C2=C(C1)Nc1ccc(C(=O)O)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
44333866 163748 0 None - 0 Human 6.0 pIC50 = 6 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 641 8 4 3 8.5 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3cc(F)ccc3c2C1F 10.1016/j.bmcl.2004.04.045
CHEMBL421216 163748 0 None - 0 Human 6.0 pIC50 = 6 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 641 8 4 3 8.5 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3cc(F)ccc3c2C1F 10.1016/j.bmcl.2004.04.045
CHEMBL2371724 208372 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibition of tachykinin receptor 3 expressed in human ileal carcinoid cellsInhibition of tachykinin receptor 3 expressed in human ileal carcinoid cells
ChEMBL None None None CCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)C(CNCCN)CNCCN)C(C)C)C(N)=O 10.1021/jm049437y
45267292 194315 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 362 2 2 4 5.2 COc1ccccc1C1Nc2cc(C)ccc2NC2=C1C(=O)CC(C)(C)C2 10.1016/j.bmcl.2009.05.124
CHEMBL559859 194315 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 362 2 2 4 5.2 COc1ccccc1C1Nc2cc(C)ccc2NC2=C1C(=O)CC(C)(C)C2 10.1016/j.bmcl.2009.05.124
44334408 4943 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 589 6 4 3 6.6 O=C(Nc1ccc(C(F)(F)F)cc1)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL105068 4943 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 589 6 4 3 6.6 O=C(Nc1ccc(C(F)(F)F)cc1)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
134157223 153045 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1495 42 16 22 -5.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CN1CCN(CCNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)CC1)C(C)C)C(N)=O nan
CHEMBL3980433 153045 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1495 42 16 22 -5.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CN1CCN(CCNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)CC1)C(C)C)C(N)=O nan
134147546 149102 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1614 52 18 24 -6.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCCOCCNC(=O)CN1CCN(C(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)CC1)C(C)C)C(N)=O nan
CHEMBL3947283 149102 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1614 52 18 24 -6.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCCOCCNC(=O)CN1CCN(C(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)CC1)C(C)C)C(N)=O nan
134135762 143968 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1599 50 20 24 -7.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CN1CCN(CCNC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)CC1)C(C)C)C(N)=O nan
CHEMBL3906914 143968 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1599 50 20 24 -7.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CN1CCN(CCNC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)CC1)C(C)C)C(N)=O nan
4604199 193396 18 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 350 1 2 3 5.4 Cc1ccc2c(c1)NC(c1ccccc1F)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL549567 193396 18 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 350 1 2 3 5.4 Cc1ccc2c(c1)NC(c1ccccc1F)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
45269876 193745 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 454 2 2 4 6.6 CC1(C)CC(=O)C2=C(C1)Nc1ccc(OC(F)(F)F)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
CHEMBL552191 193745 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 454 2 2 4 6.6 CC1(C)CC(=O)C2=C(C1)Nc1ccc(OC(F)(F)F)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
45271526 194718 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 395 1 2 4 5.6 CC1(C)CC(=O)C2=C(C1)Nc1ccc(C#N)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
CHEMBL562708 194718 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 395 1 2 4 5.6 CC1(C)CC(=O)C2=C(C1)Nc1ccc(C#N)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
134149621 148098 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1449 45 16 19 -2.2 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CCCCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
CHEMBL3939368 148098 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1449 45 16 19 -2.2 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CCCCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
45273323 194026 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 356 1 2 3 5.4 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CCCC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL556898 194026 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 356 1 2 3 5.4 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CCCC1=O)N2 10.1016/j.bmcl.2009.05.124
134151148 151049 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1535 41 16 20 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1cccc(-c2ccc(CNC(=O)CN3CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC3)cc2)c1)C(C)C)C(N)=O nan
CHEMBL3963362 151049 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1535 41 16 20 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1cccc(-c2ccc(CNC(=O)CN3CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC3)cc2)c1)C(C)C)C(N)=O nan
5311352 2984 5 None - 1 Rat 6.8 pIC50 = 6.8 Binding
Binding affinity against NMB receptor in rat olfactory bulb was determined using [125I]-[Tyr4] bombesin.Binding affinity against NMB receptor in rat olfactory bulb was determined using [125I]-[Tyr4] bombesin.
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/0960-894X(96)00481-7
620 2984 5 None - 1 Rat 6.8 pIC50 = 6.8 Binding
Binding affinity against NMB receptor in rat olfactory bulb was determined using [125I]-[Tyr4] bombesin.Binding affinity against NMB receptor in rat olfactory bulb was determined using [125I]-[Tyr4] bombesin.
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/0960-894X(96)00481-7
CHEMBL86828 2984 5 None - 1 Rat 6.8 pIC50 = 6.8 Binding
Binding affinity against NMB receptor in rat olfactory bulb was determined using [125I]-[Tyr4] bombesin.Binding affinity against NMB receptor in rat olfactory bulb was determined using [125I]-[Tyr4] bombesin.
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/0960-894X(96)00481-7
45267295 194316 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 440 4 1 3 7.2 CCCCN1c2cc(C)ccc2NC2=C(C(=O)CC(C)(C)C2)C1c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
CHEMBL559860 194316 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 440 4 1 3 7.2 CCCCN1c2cc(C)ccc2NC2=C(C(=O)CC(C)(C)C2)C1c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
134152521 151005 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1360 37 15 19 -3.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
CHEMBL3963000 151005 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1360 37 15 19 -3.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
45270715 194844 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 398 1 1 3 6.0 Cc1ccc2c(c1)N(C)C(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL563564 194844 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 398 1 1 3 6.0 Cc1ccc2c(c1)N(C)C(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
134151766 152625 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1397 40 16 20 -4.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
CHEMBL3976771 152625 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1397 40 16 20 -4.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
45270716 193104 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 412 2 1 3 6.4 CCN1c2cc(C)ccc2NC2=C(C(=O)CC(C)(C)C2)C1c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
CHEMBL538178 193104 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 412 2 1 3 6.4 CCN1c2cc(C)ccc2NC2=C(C(=O)CC(C)(C)C2)C1c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
44334409 4944 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 665 10 4 7 6.0 CCOC(=O)c1cc(NC(=O)NC2(C(=O)NCC3(c4ccccn4)CCCCC3)CCc3[nH]c4ccccc4c3C2)cc(C(=O)OCC)c1 10.1016/j.bmcl.2004.04.045
CHEMBL105069 4944 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 665 10 4 7 6.0 CCOC(=O)c1cc(NC(=O)NC2(C(=O)NCC3(c4ccccn4)CCCCC3)CCc3[nH]c4ccccc4c3C2)cc(C(=O)OCC)c1 10.1016/j.bmcl.2004.04.045
44333537 111089 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 689 9 4 4 8.8 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3cccc(OC(F)(F)F)c3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL328166 111089 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 689 9 4 4 8.8 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3cccc(OC(F)(F)F)c3c2C1 10.1016/j.bmcl.2004.04.045
134133036 144007 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1586 51 23 23 -7.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
CHEMBL3907272 144007 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1586 51 23 23 -7.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
11434815 96488 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of tachykinin receptor 3 expressed in human ileal carcinoid cellsInhibition of tachykinin receptor 3 expressed in human ileal carcinoid cells
ChEMBL 1285 44 17 17 -2.2 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCC(=O)Nc1ccc(CC(CNCCN)CNCCN)cc1)C(C)C)C(N)=O 10.1021/jm049437y
CHEMBL266079 96488 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of tachykinin receptor 3 expressed in human ileal carcinoid cellsInhibition of tachykinin receptor 3 expressed in human ileal carcinoid cells
ChEMBL 1285 44 17 17 -2.2 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCC(=O)Nc1ccc(CC(CNCCN)CNCCN)cc1)C(C)C)C(N)=O 10.1021/jm049437y
134135229 143690 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1558 51 21 23 -7.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
CHEMBL3904512 143690 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1558 51 21 23 -7.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
87217489 144423 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1516 41 17 21 -3.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)c(C)c1)C(C)C)C(N)=O nan
CHEMBL3910471 144423 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1516 41 17 21 -3.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)c(C)c1)C(C)C)C(N)=O nan
87217658 152790 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1754 44 17 22 -0.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](NC(=O)CNC(=O)CN5CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC5)CC[C@]4(C)[C@H]3CC(=O)[C@@]21C)C(C)C)C(N)=O nan
CHEMBL3978233 152790 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1754 44 17 22 -0.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](NC(=O)CNC(=O)CN5CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC5)CC[C@]4(C)[C@H]3CC(=O)[C@@]21C)C(C)C)C(N)=O nan
87217674 147503 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1465 40 16 20 -3.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CC[C@H](CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)CC1)C(C)C)C(N)=O nan
CHEMBL3934601 147503 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1465 40 16 20 -3.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CC[C@H](CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)CC1)C(C)C)C(N)=O nan
117745216 142483 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1517 42 18 22 -4.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NNC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
CHEMBL3894747 142483 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1517 42 18 22 -4.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NNC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
134153217 151900 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1457 46 19 21 -6.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
CHEMBL3970735 151900 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1457 46 19 21 -6.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
45269883 193868 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 378 2 2 4 5.9 CSc1ccccc1C1Nc2cc(C)ccc2NC2=C1C(=O)CC(C)(C)C2 10.1016/j.bmcl.2009.05.124
CHEMBL554477 193868 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 378 2 2 4 5.9 CSc1ccccc1C1Nc2cc(C)ccc2NC2=C1C(=O)CC(C)(C)C2 10.1016/j.bmcl.2009.05.124
45270721 193754 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 462 3 2 4 6.8 COc1ccc(C2CC(=O)C3=C(C2)Nc2ccc(C)cc2NC3c2c(F)cccc2Cl)cc1 10.1016/j.bmcl.2009.05.124
CHEMBL552257 193754 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 462 3 2 4 6.8 COc1ccc(C2CC(=O)C3=C(C2)Nc2ccc(C)cc2NC3c2c(F)cccc2Cl)cc1 10.1016/j.bmcl.2009.05.124
CHEMBL3894546 210678 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
44333806 4520 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 683 8 4 3 8.6 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3cc(Br)ccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL102647 4520 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 683 8 4 3 8.6 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3cc(Br)ccc3c2C1 10.1016/j.bmcl.2004.04.045
45269877 194198 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 400 2 2 4 5.7 COc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL558803 194198 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 400 2 2 4 5.7 COc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
44334154 5023 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 563 7 4 4 5.8 CC(=O)c1cccc(NC(=O)NC2(C(=O)NCC3(c4ccccn4)CCCCC3)CCc3[nH]c4ccccc4c3C2)c1 10.1016/j.bmcl.2004.04.045
CHEMBL105543 5023 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 563 7 4 4 5.8 CC(=O)c1cccc(NC(=O)NC2(C(=O)NCC3(c4ccccn4)CCCCC3)CCc3[nH]c4ccccc4c3C2)c1 10.1016/j.bmcl.2004.04.045
134147351 149044 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1558 51 21 23 -7.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
CHEMBL3946856 149044 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1558 51 21 23 -7.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
45269049 194734 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 392 1 2 3 6.4 Cc1ccc2c(c1)NC(c1ccccc1Cl)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL562834 194734 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 392 1 2 3 6.4 Cc1ccc2c(c1)NC(c1ccccc1Cl)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
44333515 4677 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
CHEMBL103756 4677 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
45267305 194405 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 404 2 2 4 6.5 CSc1ccccc1C1Nc2cc(C)ccc2NC2=C1C(=O)CC1(CCCC1)C2 10.1016/j.bmcl.2009.05.124
CHEMBL560655 194405 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 404 2 2 4 6.5 CSc1ccccc1C1Nc2cc(C)ccc2NC2=C1C(=O)CC1(CCCC1)C2 10.1016/j.bmcl.2009.05.124
45269034 194838 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 400 1 2 3 6.2 Cc1ccc2c(c1)NC(c1ccccc1C(F)(F)F)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL563531 194838 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 400 1 2 3 6.2 Cc1ccc2c(c1)NC(c1ccccc1C(F)(F)F)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
45272445 193493 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 368 1 2 3 5.5 Cc1ccc2c(c1)NC(c1c(F)cccc1F)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL550367 193493 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 368 1 2 3 5.5 Cc1ccc2c(c1)NC(c1c(F)cccc1F)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
45269043 194658 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 410 1 2 3 6.5 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL562376 194658 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 410 1 2 3 6.5 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
2876782 194938 13 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 366 1 2 3 5.9 Cc1ccc2c(c1)NC(c1ccccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL564151 194938 13 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 366 1 2 3 5.9 Cc1ccc2c(c1)NC(c1ccccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
44333515 4677 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
CHEMBL103756 4677 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 635 9 4 4 7.9 COc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
10124999 152897 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1467 45 16 20 -2.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CCCCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
CHEMBL3979188 152897 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1467 45 16 20 -2.7 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CCCCCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
87237371 148404 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1772 44 19 23 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@H](NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)C[C@H]1C[C@H]3O)C(C)C)C(N)=O nan
CHEMBL3941920 148404 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1772 44 19 23 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@H](NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)C[C@H]1C[C@H]3O)C(C)C)C(N)=O nan
CHEMBL3967904 210752 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H]1CCCN1)C(C)C)C(N)=O nan
117745207 143536 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1494 40 16 21 -4.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)C1CCN(C(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)CC1)C(C)C)C(N)=O nan
CHEMBL3903246 143536 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1494 40 16 21 -4.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)C1CCN(C(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)CC1)C(C)C)C(N)=O nan
87217686 150949 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1756 44 18 22 -0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](NC(=O)CNC(=O)CN5CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC5)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C)C(C)C)C(N)=O nan
CHEMBL3962308 150949 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1756 44 18 22 -0.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](NC(=O)CNC(=O)CN5CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC5)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C)C(C)C)C(N)=O nan
44250209 194812 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 426 1 2 3 6.8 Cc1ccc2c(c1)NC(c1ccccc1C(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL563374 194812 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 426 1 2 3 6.8 Cc1ccc2c(c1)NC(c1ccccc1C(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
3622597 193744 11 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 384 1 2 3 6.0 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL552189 193744 11 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 384 1 2 3 6.0 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
45273328 194725 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 422 2 2 4 6.4 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(c3ccco3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL562770 194725 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 422 2 2 4 6.4 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(c3ccco3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
44334155 5119 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 605 7 4 4 6.5 O=C(Nc1ccc(OC(F)(F)F)cc1)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL106065 5119 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 605 7 4 4 6.5 O=C(Nc1ccc(OC(F)(F)F)cc1)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
44334117 107009 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 605 8 4 3 7.9 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL318548 107009 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 605 8 4 3 7.9 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
134143221 144952 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1603 54 20 24 -7.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCCOCCNC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
CHEMBL3914573 144952 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1603 54 20 24 -7.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCCOCCNC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
44333815 158681 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 563 8 4 3 6.7 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL409885 158681 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 563 8 4 3 6.7 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
5311352 2984 5 None - 1 Human 6.5 pIC50 = 6.5 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/j.bmcl.2004.04.045
620 2984 5 None - 1 Human 6.5 pIC50 = 6.5 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/j.bmcl.2004.04.045
CHEMBL86828 2984 5 None - 1 Human 6.5 pIC50 = 6.5 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/j.bmcl.2004.04.045
44333512 4627 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 673 8 4 3 8.9 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3cccc(C(F)(F)F)c3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL103430 4627 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 673 8 4 3 8.9 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3cccc(C(F)(F)F)c3c2C1 10.1016/j.bmcl.2004.04.045
45273296 194955 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 438 1 2 3 6.7 CC1(C)CC(=O)C2=C(C1)Nc1ccc(C(F)(F)F)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
CHEMBL564278 194955 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 438 1 2 3 6.7 CC1(C)CC(=O)C2=C(C1)Nc1ccc(C(F)(F)F)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
44334136 4961 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 527 6 4 3 5.4 O=C(NC1CCCCC1)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL105154 4961 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 527 6 4 3 5.4 O=C(NC1CCCCC1)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
44317781 203994 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 565 8 4 3 7.0 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC(C)(C)c2ccccn2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL82410 203994 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 565 8 4 3 7.0 CC(C)c1cccc(C(C)C)c1NC(=O)NC1(C(=O)NCC(C)(C)c2ccccn2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
45272451 193520 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 370 1 2 3 5.6 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL550558 193520 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 370 1 2 3 5.6 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
134137917 147238 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1411 41 16 20 -4.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
CHEMBL3932563 147238 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1411 41 16 20 -4.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
45272456 193523 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 444 1 2 3 6.9 Cc1ccc2c(c1)NC(c1c(F)cccc1C(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL550567 193523 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 444 1 2 3 6.9 Cc1ccc2c(c1)NC(c1c(F)cccc1C(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
45271543 193702 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 475 3 2 4 6.8 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(c3ccc(N(C)C)cc3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL551917 193702 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 475 3 2 4 6.8 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(c3ccc(N(C)C)cc3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
44334156 107759 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 549 6 4 3 6.2 Cc1cccc(C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL319705 107759 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 549 6 4 3 6.2 Cc1cccc(C)c1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
45269039 194603 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 377 2 2 5 5.1 Cc1ccc2c(c1)NC(c1ccccc1[N+](=O)[O-])C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL561979 194603 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 377 2 2 5 5.1 Cc1ccc2c(c1)NC(c1ccccc1[N+](=O)[O-])C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
134139924 146060 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1599 54 21 23 -5.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
CHEMBL3923123 146060 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1599 54 21 23 -5.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
87217835 149643 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1459 40 16 20 -3.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
CHEMBL3951758 149643 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1459 40 16 20 -3.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)cc1)C(C)C)C(N)=O nan
134146430 148702 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1600 53 21 23 -6.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
CHEMBL3944228 148702 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1600 53 21 23 -6.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
44334387 4629 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 580 7 4 5 5.8 Cc1cc([N+](=O)[O-])ccc1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL103439 4629 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 580 7 4 5 5.8 Cc1cc([N+](=O)[O-])ccc1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
45273329 194099 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 458 2 2 4 7.4 Cc1ccc2c(c1)NC(c1ccccc1SC(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL557707 194099 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 458 2 2 4 7.4 Cc1ccc2c(c1)NC(c1ccccc1SC(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL3982672 210774 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CC1CCCCC1)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
44333532 4276 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 619 8 4 3 8.2 Cc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
CHEMBL101026 4276 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 619 8 4 3 8.2 Cc1cccc2[nH]c3c(c12)CC(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
2883854 194537 9 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 332 1 2 3 5.2 Cc1ccc2c(c1)NC(c1ccccc1)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL561518 194537 9 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 332 1 2 3 5.2 Cc1ccc2c(c1)NC(c1ccccc1)C1=C(CC(C)(C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
134157363 153339 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1400 44 18 20 -6.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
CHEMBL3982939 153339 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1400 44 18 20 -6.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CO)NC(=O)CN(C)C)C(C)C)C(N)=O nan
44333533 4108 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 633 8 4 3 8.7 Cc1ccc2[nH]c3c(c2c1)C(C)C(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
CHEMBL100065 4108 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 633 8 4 3 8.7 Cc1ccc2[nH]c3c(c2c1)C(C)C(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
25025860 563 26 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human NMB-R expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human NMB-R expressed in NFAT-CHO cells after 2 hrs by scintillation counting
ChEMBL 333 7 1 2 5.2 CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C 10.1016/j.bmcl.2010.02.076
6188 563 26 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human NMB-R expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human NMB-R expressed in NFAT-CHO cells after 2 hrs by scintillation counting
ChEMBL 333 7 1 2 5.2 CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C 10.1016/j.bmcl.2010.02.076
CHEMBL1091720 563 26 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human NMB-R expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human NMB-R expressed in NFAT-CHO cells after 2 hrs by scintillation counting
ChEMBL 333 7 1 2 5.2 CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C 10.1016/j.bmcl.2010.02.076
CHEMBL3901298 210692 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCC(N)=O)C(C)C)C(N)=O nan
CHEMBL3929807 210714 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC1CCCCC1)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
44333533 4108 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 633 8 4 3 8.7 Cc1ccc2[nH]c3c(c2c1)C(C)C(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
CHEMBL100065 4108 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 633 8 4 3 8.7 Cc1ccc2[nH]c3c(c2c1)C(C)C(NC(=O)Nc1c(C(C)C)cccc1C(C)C)(C(=O)NCC1(c2ccccn2)CCCCC1)CC3 10.1016/j.bmcl.2004.04.045
44334388 4630 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 566 7 4 5 5.5 O=C(Nc1ccc([N+](=O)[O-])cc1)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL103440 4630 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 566 7 4 5 5.5 O=C(Nc1ccc([N+](=O)[O-])cc1)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
45273322 194874 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 398 2 2 3 6.3 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C(C)C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL563752 194874 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 398 2 2 3 6.3 Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C(C)C)CC1=O)N2 10.1016/j.bmcl.2009.05.124
4078100 194945 10 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 404 1 2 3 6.4 CC1(C)CC(=O)C2=C(C1)Nc1ccc(Cl)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
CHEMBL564193 194945 10 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 404 1 2 3 6.4 CC1(C)CC(=O)C2=C(C1)Nc1ccc(Cl)cc1NC2c1c(F)cccc1Cl 10.1016/j.bmcl.2009.05.124
44333754 5045 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 551 7 4 4 5.6 COc1ccccc1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
CHEMBL105627 5045 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cellsAffinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
ChEMBL 551 7 4 4 5.6 COc1ccccc1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 10.1016/j.bmcl.2004.04.045
134144355 149959 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1774 47 17 22 -0.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)C(Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
CHEMBL3954412 149959 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1774 47 17 22 -0.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)C(Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(C)C)C(N)=O nan
134137019 142141 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1518 41 18 22 -4.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)c(O)c1)C(C)C)C(N)=O nan
CHEMBL3891981 142141 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Displacement of [125I]-NMB from NMB receptor in rat C6 cellsDisplacement of [125I]-NMB from NMB receptor in rat C6 cells
ChEMBL 1518 41 18 22 -4.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)c1ccc(NC(=O)CNC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)c(O)c1)C(C)C)C(N)=O nan
44250209 194812 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 426 1 2 3 6.8 Cc1ccc2c(c1)NC(c1ccccc1C(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
CHEMBL563374 194812 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cellsDisplacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
ChEMBL 426 1 2 3 6.8 Cc1ccc2c(c1)NC(c1ccccc1C(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 10.1016/j.bmcl.2009.05.124
44301562 197819 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 494 10 4 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL59187 197819 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 494 10 4 3 4.9 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
44322391 106577 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 502 9 4 2 6.8 CC(C)c1cccc(C(C)C)c1NC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC1CCCCC1 10.1016/0960-894X(96)00481-7
CHEMBL315660 106577 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 502 9 4 2 6.8 CC(C)c1cccc(C(C)C)c1NC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC1CCCCC1 10.1016/0960-894X(96)00481-7
21255272 204901 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 4 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NCC1CCCCC1 10.1016/0960-894X(96)00481-7
CHEMBL89153 204901 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 4 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NCC1CCCCC1 10.1016/0960-894X(96)00481-7
57402754 67416 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 550 8 4 2 7.7 CC(C)c1cccc(C(C)C)c1NC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCCc2ccccc21 10.1016/0960-894X(96)00481-7
CHEMBL1907865 67416 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 550 8 4 2 7.7 CC(C)c1cccc(C(C)C)c1NC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCCc2ccccc21 10.1016/0960-894X(96)00481-7
101835328 696 35 None -7 5 Human 8.7 pKi = 8.7 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL None None None None 10.1016/0960-894X(96)00481-7
16133800 696 35 None -7 5 Human 8.7 pKi = 8.7 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL None None None None 10.1016/0960-894X(96)00481-7
16201612 696 35 None -7 5 Human 8.7 pKi = 8.7 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL None None None None 10.1016/0960-894X(96)00481-7
616 696 35 None -7 5 Human 8.7 pKi = 8.7 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL None None None None 10.1016/0960-894X(96)00481-7
91898967 696 35 None -7 5 Human 8.7 pKi = 8.7 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL None None None None 10.1016/0960-894X(96)00481-7
CHEMBL437027 696 35 None -7 5 Human 8.7 pKi = 8.7 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL None None None None 10.1016/0960-894X(96)00481-7
DB11724 696 35 None -7 5 Human 8.7 pKi = 8.7 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL None None None None 10.1016/0960-894X(96)00481-7
CHEMBL269432 209043 0 None -2 2 Human 8.7 pKi = 8.7 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL None None None CC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)O)C(C)C 10.1016/0960-894X(96)00481-7
44322247 204747 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 3 2 6.9 CC(C)c1cccc(C(C)C)c1N(C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC1CCCCC1 10.1016/0960-894X(96)00481-7
CHEMBL88174 204747 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 3 2 6.9 CC(C)c1cccc(C(C)C)c1N(C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC1CCCCC1 10.1016/0960-894X(96)00481-7
10432902 100156 0 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 431 9 4 4 3.1 O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
CHEMBL291924 100156 0 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 431 9 4 4 3.1 O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
44301871 100280 4 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 441 9 3 3 4.4 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
CHEMBL292766 100280 4 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 441 9 3 3 4.4 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
44301546 100157 0 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 431 9 4 4 3.1 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
CHEMBL291925 100157 0 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 431 9 4 4 3.1 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
44301784 199172 0 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 460 10 4 3 4.7 CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL60125 199172 0 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 460 10 4 3 4.7 CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
40875375 198366 1 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 480 9 4 3 4.8 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
CHEMBL59561 198366 1 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 480 9 4 3 4.8 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
21255275 204581 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 502 8 4 2 7.0 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCCCC1 10.1016/0960-894X(96)00481-7
CHEMBL87090 204581 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 502 8 4 2 7.0 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCCCC1 10.1016/0960-894X(96)00481-7
44322304 204984 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 550 8 4 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCc2ccccc2C1 10.1016/0960-894X(96)00481-7
CHEMBL89795 204984 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 550 8 4 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCc2ccccc2C1 10.1016/0960-894X(96)00481-7
44301769 197642 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 446 9 4 3 4.3 CC(C)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL59055 197642 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 446 9 4 3 4.3 CC(C)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
10484081 100175 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 625 12 3 5 6.8 CC(C)CNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1 10.1016/S0960-894X(97)00346-6
CHEMBL292119 100175 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 625 12 3 5 6.8 CC(C)CNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1 10.1016/S0960-894X(97)00346-6
44322245 105504 0 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 434 7 4 2 5.3 CNC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)Nc1c(C(C)C)cccc1C(C)C 10.1016/0960-894X(96)00481-7
CHEMBL313114 105504 0 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 434 7 4 2 5.3 CNC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)Nc1c(C(C)C)cccc1C(C)C 10.1016/0960-894X(96)00481-7
44301371 100493 0 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 470 9 5 4 3.6 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
CHEMBL294165 100493 0 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 470 9 5 4 3.6 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
44301825 100349 0 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 397 9 4 4 2.9 CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
CHEMBL293240 100349 0 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 397 9 4 4 2.9 CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
10000877 101136 0 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 397 9 4 4 2.9 CC(C)CCNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
CHEMBL298816 101136 0 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 397 9 4 4 2.9 CC(C)CCNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OCc1c[nH]cn1 10.1016/S0960-894X(97)00346-6
44322461 155328 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 610 9 4 4 7.5 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1COC(C)(C)OC1c1ccccc1 10.1016/0960-894X(96)00481-7
CHEMBL406037 155328 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 610 9 4 4 7.5 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1COC(C)(C)OC1c1ccccc1 10.1016/0960-894X(96)00481-7
44301870 201002 0 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 407 9 3 3 3.8 CC(C)COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00346-6
CHEMBL61615 201002 0 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 407 9 3 3 3.8 CC(C)COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00346-6
44322341 105457 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 4 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(C)C1CCCCC1 10.1016/0960-894X(96)00481-7
CHEMBL312851 105457 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 4 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(C)C1CCCCC1 10.1016/0960-894X(96)00481-7
44322126 105710 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 524 10 4 2 6.9 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1016/0960-894X(96)00481-7
CHEMBL313829 105710 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 524 10 4 2 6.9 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1016/0960-894X(96)00481-7
44302017 197651 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 446 9 4 3 4.3 CC(C)COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL59060 197651 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 446 9 4 3 4.3 CC(C)COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
21255273 111100 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 3 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N(C)CC1CCCCC1 10.1016/0960-894X(96)00481-7
CHEMBL328230 111100 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 3 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N(C)CC1CCCCC1 10.1016/0960-894X(96)00481-7
44301554 200742 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 484 10 5 4 3.6 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]cn1)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL61098 200742 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 484 10 5 4 3.6 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]cn1)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
5311352 2984 5 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/0960-894X(96)00481-7
620 2984 5 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/0960-894X(96)00481-7
CHEMBL86828 2984 5 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/0960-894X(96)00481-7
5311352 2984 5 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against human NMB receptor was determinedBinding affinity against human NMB receptor was determined
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/0960-894X(96)00481-7
620 2984 5 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against human NMB receptor was determinedBinding affinity against human NMB receptor was determined
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/0960-894X(96)00481-7
CHEMBL86828 2984 5 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity against human NMB receptor was determinedBinding affinity against human NMB receptor was determined
ChEMBL 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C 10.1016/0960-894X(96)00481-7
40652201 197413 0 None - 1 Human 5.2 pKi = 5.2 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 407 9 3 3 4.2 CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
CHEMBL58852 197413 0 None - 1 Human 5.2 pKi = 5.2 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 407 9 3 3 4.2 CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
44322460 205420 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 534 8 4 4 5.8 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NC1COC(C)(C)OC1 10.1016/0960-894X(96)00481-7
CHEMBL92274 205420 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 534 8 4 4 5.8 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NC1COC(C)(C)OC1 10.1016/0960-894X(96)00481-7
44322303 111885 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 592 10 4 2 8.6 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CCCCC1 10.1016/0960-894X(96)00481-7
CHEMBL329561 111885 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 592 10 4 2 8.6 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CCCCC1 10.1016/0960-894X(96)00481-7
21255282 106601 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 550 8 4 2 7.7 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCCc2ccccc21 10.1016/0960-894X(96)00481-7
CHEMBL315859 106601 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 550 8 4 2 7.7 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCCc2ccccc21 10.1016/0960-894X(96)00481-7
57391433 67350 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 578 9 4 2 8.4 CC(C)c1cccc(C(C)C)c1NC(=O)N[C@@](C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCCCC1c1ccccc1 10.1016/0960-894X(96)00481-7
CHEMBL1907682 67350 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 578 9 4 2 8.4 CC(C)c1cccc(C(C)C)c1NC(=O)N[C@@](C)(Cc1c[nH]c2ccccc12)C(=O)NC1CCCCC1c1ccccc1 10.1016/0960-894X(96)00481-7
21255267 111158 0 None 1 2 Human 6.1 pKi = 6.1 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 3 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)N(C)C(Cc1c[nH]c2ccccc12)C(=O)NCC1CCCCC1 10.1016/0960-894X(96)00481-7
CHEMBL328591 111158 0 None 1 2 Human 6.1 pKi = 6.1 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 516 9 3 2 7.2 CC(C)c1cccc(C(C)C)c1NC(=O)N(C)C(Cc1c[nH]c2ccccc12)C(=O)NCC1CCCCC1 10.1016/0960-894X(96)00481-7
44301939 199259 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 475 12 5 4 3.8 NCCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL60176 199259 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 475 12 5 4 3.8 NCCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL525577 213877 0 None -24 3 Human 8.1 pKi = 8.1 Binding
Binding affinity to neuromedin B receptorBinding affinity to neuromedin B receptor
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O 10.1016/j.bmcl.2008.09.033
44301811 101533 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 461 11 5 4 3.4 NCCCCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL301636 101533 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 461 11 5 4 3.4 NCCCCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
44322273 204892 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 610 9 4 4 7.5 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H]1COC(C)(C)OC1c1ccccc1 10.1016/0960-894X(96)00481-7
CHEMBL89075 204892 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cellsBinding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
ChEMBL 610 9 4 4 7.5 CC(C)c1cccc(C(C)C)c1NC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H]1COC(C)(C)OC1c1ccccc1 10.1016/0960-894X(96)00481-7
44301807 162657 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 533 10 5 3 5.4 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
CHEMBL418299 162657 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cellsBinding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
ChEMBL 533 10 5 3 5.4 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1c[nH]c2ccccc12)OCCc1c[nH]c2ccccc12 10.1016/S0960-894X(97)00346-6
5311352 2984 5 None - 1 Human 8.2 pKd = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C None
620 2984 5 None - 1 Human 8.2 pKd = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C None
CHEMBL86828 2984 5 None - 1 Human 8.2 pKd = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 593 10 4 3 8.0 O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1c(cccc1C(C)C)C(C)C None
5281668 2172 0 None - 1 Rat 5.2 pKi = 5.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 760 9 8 11 8.8 CC(=CCc1c(O)ccc(c1O)C(=O)[C@H]1[C@@H](CC(=C[C@@H]1c1c(O)cc(c2c1oc(c1ccc(cc1O)O)c(c2=O)CC=C(C)C)O)C)c1ccc(cc1O)O)C 7646517
622 2172 0 None - 1 Rat 5.2 pKi = 5.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 760 9 8 11 8.8 CC(=CCc1c(O)ccc(c1O)C(=O)[C@H]1[C@@H](CC(=C[C@@H]1c1c(O)cc(c2c1oc(c1ccc(cc1O)O)c(c2=O)CC=C(C)C)O)C)c1ccc(cc1O)O)C 7646517
CHEMBL506234 2172 0 None - 1 Rat 5.2 pKi = 5.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 760 9 8 11 8.8 CC(=CCc1c(O)ccc(c1O)C(=O)[C@H]1[C@@H](CC(=C[C@@H]1c1c(O)cc(c2c1oc(c1ccc(cc1O)O)c(c2=O)CC=C(C)C)O)C)c1ccc(cc1O)O)C 7646517
155817488 3275 0 None -14 2 Rat 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
155817488 3275 0 None -14 2 Rat 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
57340152 3275 0 None -14 2 Rat 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
57340152 3275 0 None -14 2 Rat 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
6165 3275 0 None -14 2 Rat 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
6165 3275 0 None -14 2 Rat 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
612 1745 0 None -288 5 Rat 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
612 1745 0 None -288 5 Rat 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
612 1745 0 None -288 5 Rat 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
612 1745 0 None -288 5 Rat 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
CHEMBL413196 1745 0 None -288 5 Rat 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
CHEMBL413196 1745 0 None -288 5 Rat 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
CHEMBL413196 1745 0 None -288 5 Rat 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
CHEMBL413196 1745 0 None -288 5 Rat 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
635 1422 0 None 1 3 Rat 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
155817489 3066 0 None 5 2 Rat 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
155817489 3066 0 None 5 2 Rat 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
6166 3066 0 None 5 2 Rat 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
6166 3066 0 None 5 2 Rat 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
615 3053 0 None -58 3 Rat 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
615 3053 0 None -58 3 Rat 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
615 3053 0 None -58 3 Rat 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
101835328 696 35 None -7 5 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
101835328 696 35 None -7 5 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
16133800 696 35 None -7 5 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
16133800 696 35 None -7 5 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
16201612 696 35 None -7 5 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
16201612 696 35 None -7 5 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
616 696 35 None -7 5 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
616 696 35 None -7 5 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
91898967 696 35 None -7 5 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
91898967 696 35 None -7 5 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
CHEMBL437027 696 35 None -7 5 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
CHEMBL437027 696 35 None -7 5 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
DB11724 696 35 None -7 5 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
DB11724 696 35 None -7 5 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
101835328 696 35 None -24 5 Rat 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
101835328 696 35 None -24 5 Rat 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
16133800 696 35 None -24 5 Rat 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
16133800 696 35 None -24 5 Rat 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
16201612 696 35 None -24 5 Rat 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
16201612 696 35 None -24 5 Rat 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
616 696 35 None -24 5 Rat 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
616 696 35 None -24 5 Rat 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
91898967 696 35 None -24 5 Rat 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
91898967 696 35 None -24 5 Rat 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
CHEMBL437027 696 35 None -24 5 Rat 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
CHEMBL437027 696 35 None -24 5 Rat 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
DB11724 696 35 None -24 5 Rat 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
DB11724 696 35 None -24 5 Rat 7.6 pKi = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7838118
22146595 3238 0 None -6 3 Rat 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
22146595 3238 0 None -6 3 Rat 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
618 3238 0 None -6 3 Rat 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
618 3238 0 None -6 3 Rat 7.9 pKi = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
14235547 2298 0 None -1 2 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
14235547 2298 0 None -1 2 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
617 2298 0 None -1 2 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
617 2298 0 None -1 2 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
632 1450 0 None -1 5 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10454496
632 1450 0 None -1 5 Human 8.8 pKi = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
4345957 2727 0 None 89 4 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18055507
4345957 2727 0 None 89 4 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
4345957 2727 0 None 89 4 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 25976083
613 2727 0 None 89 4 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18055507
613 2727 0 None 89 4 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21729729
613 2727 0 None 89 4 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 25976083
155817490 2275 0 None -23 2 Rat 5.0 pKi > 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
155817490 2275 0 None -23 2 Rat 5.0 pKi > 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344
6168 2275 0 None -23 2 Rat 5.0 pKi > 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10353842
6168 2275 0 None -23 2 Rat 5.0 pKi > 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9325344