Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
2924 8421 43 None -6 7 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human S1P4 receptor by GTPgammaS binding assayAgonist activity at human S1P4 receptor by GTPgammaS binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/acsmedchemlett.5b00448
44398069 8421 43 None -6 7 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human S1P4 receptor by GTPgammaS binding assayAgonist activity at human S1P4 receptor by GTPgammaS binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/acsmedchemlett.5b00448
9908268 8421 43 None -6 7 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human S1P4 receptor by GTPgammaS binding assayAgonist activity at human S1P4 receptor by GTPgammaS binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/acsmedchemlett.5b00448
CHEMBL114606 8421 43 None -6 7 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human S1P4 receptor by GTPgammaS binding assayAgonist activity at human S1P4 receptor by GTPgammaS binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/acsmedchemlett.5b00448
11452022 10368 39 None -26 6 Human 9.2 pEC50 = 9.2 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/jm050242f
6996 10368 39 None -26 6 Human 9.2 pEC50 = 9.2 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/jm050242f
CHEMBL366208 10368 39 None -26 6 Human 9.2 pEC50 = 9.2 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/jm050242f
11222939 74349 9 None -12 4 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1016/j.bmcl.2010.01.118
44438254 74349 9 None -12 4 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1016/j.bmcl.2010.01.118
CHEMBL190006 74349 9 None -12 4 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1016/j.bmcl.2010.01.118
10904818 7091 0 None -1 4 Human 8.9 pEC50 = 8.9 Functional
Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 373 13 3 4 3.8 CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C 10.1016/j.bmcl.2005.09.038
2937 7091 0 None -1 4 Human 8.9 pEC50 = 8.9 Functional
Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 373 13 3 4 3.8 CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C 10.1016/j.bmcl.2005.09.038
CHEMBL382739 7091 0 None -1 4 Human 8.9 pEC50 = 8.9 Functional
Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 373 13 3 4 3.8 CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C 10.1016/j.bmcl.2005.09.038
44406004 79490 10 None -7 4 Human 8.9 pEC50 = 8.9 Functional
Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 337 14 4 4 2.9 CCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(=O)(O)O 10.1016/j.bmcl.2005.09.038
CHEMBL199791 79490 10 None -7 4 Human 8.9 pEC50 = 8.9 Functional
Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 337 14 4 4 2.9 CCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(=O)(O)O 10.1016/j.bmcl.2005.09.038
11452022 10368 39 None -26 6 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/acs.jmedchem.8b01695
6996 10368 39 None -26 6 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/acs.jmedchem.8b01695
CHEMBL366208 10368 39 None -26 6 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/acs.jmedchem.8b01695
2924 8421 43 None -6 7 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/acs.jmedchem.0c01109
44398069 8421 43 None -6 7 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/acs.jmedchem.0c01109
9908268 8421 43 None -6 7 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/acs.jmedchem.0c01109
CHEMBL114606 8421 43 None -6 7 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/acs.jmedchem.0c01109
11177439 74667 0 None 239 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 413 7 4 3 3.6 N[C@H](CNC(=O)c1cc2c(-c3ccccc3Cc3ccccc3)cccc2[nH]1)C(=O)O 10.1016/j.bmcl.2011.09.049
CHEMBL1910654 74667 0 None 239 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 413 7 4 3 3.6 N[C@H](CNC(=O)c1cc2c(-c3ccccc3Cc3ccccc3)cccc2[nH]1)C(=O)O 10.1016/j.bmcl.2011.09.049
118877584 189232 0 None -15 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 411 9 3 4 3.7 CCOCCC[C@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.0c01109
CHEMBL4786296 189232 0 None -15 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 411 9 3 4 3.7 CCOCCC[C@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.0c01109
78321974 147092 0 None -21 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human S1P4 receptor by GTPgammaS binding assayAgonist activity at human S1P4 receptor by GTPgammaS binding assay
ChEMBL 409 9 3 3 4.8 CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acsmedchemlett.5b00448
CHEMBL3806205 147092 0 None -21 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human S1P4 receptor by GTPgammaS binding assayAgonist activity at human S1P4 receptor by GTPgammaS binding assay
ChEMBL 409 9 3 3 4.8 CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acsmedchemlett.5b00448
78321974 147092 0 None -21 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay
ChEMBL 409 9 3 3 4.8 CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.8b01695
CHEMBL3806205 147092 0 None -21 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay
ChEMBL 409 9 3 3 4.8 CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.8b01695
78321974 147092 0 None -21 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 409 9 3 3 4.8 CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.0c01109
CHEMBL3806205 147092 0 None -21 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 409 9 3 3 4.8 CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.0c01109
46224767 206077 0 None -14 4 Human 7.0 pEC50 = 7 Functional
Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay
ChEMBL 293 2 0 4 3.2 Cc1nn(C(=O)/C=C/c2ccncc2)c2c1[C@H]1[C@@H](C2)C1(C)C 10.1016/j.bmcl.2009.11.045
CHEMBL590383 206077 0 None -14 4 Human 7.0 pEC50 = 7 Functional
Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay
ChEMBL 293 2 0 4 3.2 Cc1nn(C(=O)/C=C/c2ccncc2)c2c1[C@H]1[C@@H](C2)C1(C)C 10.1016/j.bmcl.2009.11.045
46224768 206078 0 None -5 3 Human 7.0 pEC50 = 7 Functional
Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay
ChEMBL 293 2 0 4 3.2 Cc1nn(C(=O)/C=C/c2cccnc2)c2c1[C@H]1[C@@H](C2)C1(C)C 10.1016/j.bmcl.2009.11.045
CHEMBL590384 206078 0 None -5 3 Human 7.0 pEC50 = 7 Functional
Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay
ChEMBL 293 2 0 4 3.2 Cc1nn(C(=O)/C=C/c2cccnc2)c2c1[C@H]1[C@@H](C2)C1(C)C 10.1016/j.bmcl.2009.11.045
136042187 74694 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 347 2 1 4 3.6 C/N=C1/NC(=O)/C(=C/c2cc(C)n(-c3ccc(F)cc3F)c2C)S1 10.1016/j.bmcl.2011.09.049
CHEMBL1910799 74694 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 347 2 1 4 3.6 C/N=C1/NC(=O)/C(=C/c2cc(C)n(-c3ccc(F)cc3F)c2C)S1 10.1016/j.bmcl.2011.09.049
57395471 74695 0 None 7 3 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 389 4 0 4 4.7 CC/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3F)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
CHEMBL1910800 74695 0 None 7 3 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 389 4 0 4 4.7 CC/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3F)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
45377662 90892 0 None -354 4 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at S1P4 receptorAgonist activity at S1P4 receptor
ChEMBL 468 9 1 6 4.3 CCCCN(C(=O)c1ccccc1F)c1nnc(-c2ccc(CN3CC(C(=O)O)C3)cc2)s1 10.1016/j.bmcl.2012.09.110
CHEMBL2207778 90892 0 None -354 4 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at S1P4 receptorAgonist activity at S1P4 receptor
ChEMBL 468 9 1 6 4.3 CCCCN(C(=O)c1ccccc1F)c1nnc(-c2ccc(CN3CC(C(=O)O)C3)cc2)s1 10.1016/j.bmcl.2012.09.110
11224984 15489 23 None -218 4 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assayAgonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay
ChEMBL 460 8 2 6 4.3 CCC/N=C1\S/C(=C\c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C 10.1021/jm100181s
CHEMBL1095833 15489 23 None -218 4 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assayAgonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay
ChEMBL 460 8 2 6 4.3 CCC/N=C1\S/C(=C\c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C 10.1021/jm100181s
4097071 42671 10 None -1 2 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 400 5 0 5 5.1 COc1cccc(C2CN(c3ccc(F)cc3F)N=C2c2cccs2)c1OC nan
CHEMBL1442207 42671 10 None -1 2 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 400 5 0 5 5.1 COc1cccc(C2CN(c3ccc(F)cc3F)N=C2c2cccs2)c1OC nan
46224715 206037 0 None -10 4 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay
ChEMBL 371 3 1 5 2.5 Cc1nn(C(=O)/C=C/c2cccc(S(N)(=O)=O)c2)c2c1[C@H]1[C@@H](C2)C1(C)C 10.1016/j.bmcl.2009.11.045
CHEMBL590135 206037 0 None -10 4 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay
ChEMBL 371 3 1 5 2.5 Cc1nn(C(=O)/C=C/c2cccc(S(N)(=O)=O)c2)c2c1[C@H]1[C@@H](C2)C1(C)C 10.1016/j.bmcl.2009.11.045
135656247 79381 6 None 7 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 277 2 3 5 1.1 C/C(=N/NC(N)=S)c1cc2ccc(O)cc2oc1=O nan
CHEMBL1993778 79381 6 None 7 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 277 2 3 5 1.1 C/C(=N/NC(N)=S)c1cc2ccc(O)cc2oc1=O nan
71450073 89364 0 None -354 4 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human S1P4R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayAgonist activity at human S1P4R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assay
ChEMBL 585 10 2 5 5.5 Cc1cc(S(=O)(=O)Nc2cccc(-c3cc(C)c(C(=O)N(C)[C@@H](CCN(C)C)C(=O)O)c(C)c3)c2)c(C)cc1Cl 10.1021/jm3009508
CHEMBL2178814 89364 0 None -354 4 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human S1P4R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayAgonist activity at human S1P4R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assay
ChEMBL 585 10 2 5 5.5 Cc1cc(S(=O)(=O)Nc2cccc(-c3cc(C)c(C(=O)N(C)[C@@H](CCN(C)C)C(=O)O)c(C)c3)c2)c(C)cc1Cl 10.1021/jm3009508
44342175 92295 0 None -4 4 Human 6.9 pEC50 = 6.9 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
CHEMBL227371 92295 0 None -4 4 Human 6.9 pEC50 = 6.9 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
CHEMBL422074 92295 0 None -4 4 Human 6.9 pEC50 = 6.9 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
46866185 14104 0 None -6 4 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 321 12 2 3 4.2 CCCCCCCOc1ccc(CC[C@](C)(N)CC(=O)O)cc1 10.1016/j.bmcl.2010.01.118
CHEMBL1086172 14104 0 None -6 4 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 321 12 2 3 4.2 CCCCCCCOc1ccc(CC[C@](C)(N)CC(=O)O)cc1 10.1016/j.bmcl.2010.01.118
44620893 66419 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 361 7 0 4 4.6 COCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 nan
CHEMBL1720965 66419 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 361 7 0 4 4.6 COCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 nan
67194420 149790 0 None -23988 4 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 468 8 2 8 3.0 CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NS(=O)(=O)CCO)no2)cc1C#N nan
CHEMBL3894716 149790 0 None -23988 4 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 468 8 2 8 3.0 CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NS(=O)(=O)CCO)no2)cc1C#N nan
3122786 35220 19 None -4 4 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 334 4 0 4 5.1 COc1ccc(C2CC(c3cccs3)=NN2c2ccccc2)cc1 nan
CHEMBL1375375 35220 19 None -4 4 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 334 4 0 4 5.1 COc1ccc(C2CC(c3cccs3)=NN2c2ccccc2)cc1 nan
10883396 10421 45 None -21 15 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/ml400194r
5283560 10421 45 None -21 15 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/ml400194r
911 10421 45 None -21 15 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/ml400194r
CHEMBL225155 10421 45 None -21 15 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/ml400194r
57398735 76543 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 341 6 0 4 4.7 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c([N+](=O)[O-])c1 10.1016/j.bmcl.2011.10.096
CHEMBL1935689 76543 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 341 6 0 4 4.7 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c([N+](=O)[O-])c1 10.1016/j.bmcl.2011.10.096
57396983 76548 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 361 5 0 3 4.6 Clc1ccc(OCCOc2cccnc2Br)c(Cl)c1 10.1016/j.bmcl.2011.10.096
CHEMBL1935698 76548 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 361 5 0 3 4.6 Clc1ccc(OCCOc2cccnc2Br)c(Cl)c1 10.1016/j.bmcl.2011.10.096
44517795 75076 0 None -1318 5 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human S1P4 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assayAgonist activity at recombinant human S1P4 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assay
ChEMBL 472 6 1 7 3.9 N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4c(c3)CCN4C(=O)CCC(=O)O)no2)c1 10.1016/j.bmcl.2011.05.110
CHEMBL1916399 75076 0 None -1318 5 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human S1P4 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assayAgonist activity at recombinant human S1P4 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assay
ChEMBL 472 6 1 7 3.9 N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4c(c3)CCN4C(=O)CCC(=O)O)no2)c1 10.1016/j.bmcl.2011.05.110
11222939 74349 9 None -12 4 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1016/j.bmcl.2010.02.006
44438254 74349 9 None -12 4 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1016/j.bmcl.2010.02.006
CHEMBL190006 74349 9 None -12 4 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1016/j.bmcl.2010.02.006
46866186 14103 0 None -3 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 307 11 2 3 3.8 CCCCCCCOc1ccc(CC[C@](C)(N)C(=O)O)cc1 10.1016/j.bmcl.2010.01.118
CHEMBL1086171 14103 0 None -3 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 307 11 2 3 3.8 CCCCCCCOc1ccc(CC[C@](C)(N)C(=O)O)cc1 10.1016/j.bmcl.2010.01.118
16196418 58062 1 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 448 10 3 5 3.2 CC(C)C[C@H](NC(=O)c1[nH]cnc1C(=O)NCc1ccccc1)C(=O)OCc1ccccc1 nan
CHEMBL1580856 58062 1 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 448 10 3 5 3.2 CC(C)C[C@H](NC(=O)c1[nH]cnc1C(=O)NCc1ccccc1)C(=O)OCc1ccccc1 nan
44422605 92350 0 None -4 3 Human 6.8 pEC50 = 6.8 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 329 11 3 3 3.1 CCCCCCc1ccc(OC[C@@H](N)CCP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
CHEMBL228103 92350 0 None -4 3 Human 6.8 pEC50 = 6.8 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 329 11 3 3 3.1 CCCCCCc1ccc(OC[C@@H](N)CCP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
57398998 74687 0 None -3 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 375 3 0 4 4.0 C/N=C1\S/C(=C\c2cc(C)n(Cc3ccc(F)cc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910691 74687 0 None -3 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 375 3 0 4 4.0 C/N=C1\S/C(=C\c2cc(C)n(Cc3ccc(F)cc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
46884020 15212 0 None -89 4 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 397 11 3 3 4.5 CCCCCCCCc1ccc2c(c1)CC[C@H]([C@@](C)(N)COP(=O)(O)O)C2 10.1016/j.bmcl.2010.02.006
CHEMBL1093686 15212 0 None -89 4 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 397 11 3 3 4.5 CCCCCCCCc1ccc2c(c1)CC[C@H]([C@@](C)(N)COP(=O)(O)O)C2 10.1016/j.bmcl.2010.02.006
44422606 92348 0 None -3 5 Human 6.8 pEC50 = 6.8 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 329 11 3 3 3.1 CCCCCCc1ccc(OC[C@H](N)CCP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
CHEMBL228049 92348 0 None -3 5 Human 6.8 pEC50 = 6.8 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 329 11 3 3 3.1 CCCCCCc1ccc(OC[C@H](N)CCP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
57402269 76194 3 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 347 6 1 4 4.0 OCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1933157 76194 3 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 347 6 1 4 4.0 OCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 10.1016/j.bmcl.2011.10.096
3536865 53811 5 None - 1 Human 5.8 pEC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 426 6 2 6 2.9 CCNC(=O)NC(=O)C(C)OC(=O)c1c(C)nn(Cc2ccccc2Cl)c1Cl nan
CHEMBL1541924 53811 5 None - 1 Human 5.8 pEC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 426 6 2 6 2.9 CCNC(=O)NC(=O)C(C)OC(=O)c1c(C)nn(Cc2ccccc2Cl)c1Cl nan
124221654 7907 1 None 2 2 Human 6.8 pEC50 = 6.8 Functional
Activation of human S1PR4 expressed in CHO cells assessed as suppression of forskolin-induced intracellular cAMP level measured after 15 mins by ELISAActivation of human S1PR4 expressed in CHO cells assessed as suppression of forskolin-induced intracellular cAMP level measured after 15 mins by ELISA
ChEMBL 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 10.1016/j.bmcl.2016.11.050
9495 7907 1 None 2 2 Human 6.8 pEC50 = 6.8 Functional
Activation of human S1PR4 expressed in CHO cells assessed as suppression of forskolin-induced intracellular cAMP level measured after 15 mins by ELISAActivation of human S1PR4 expressed in CHO cells assessed as suppression of forskolin-induced intracellular cAMP level measured after 15 mins by ELISA
ChEMBL 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 10.1016/j.bmcl.2016.11.050
CHEMBL3884038 7907 1 None 2 2 Human 6.8 pEC50 = 6.8 Functional
Activation of human S1PR4 expressed in CHO cells assessed as suppression of forskolin-induced intracellular cAMP level measured after 15 mins by ELISAActivation of human S1PR4 expressed in CHO cells assessed as suppression of forskolin-induced intracellular cAMP level measured after 15 mins by ELISA
ChEMBL 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 10.1016/j.bmcl.2016.11.050
44438259 100602 0 None -2 2 Human 7.8 pEC50 = 7.8 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@@H]2C[C@@H](COP(=O)(O)O)N[C@H]2CO)cc1 10.1016/j.bmcl.2006.10.014
44438260 100602 0 None -2 2 Human 7.8 pEC50 = 7.8 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@@H]2C[C@@H](COP(=O)(O)O)N[C@H]2CO)cc1 10.1016/j.bmcl.2006.10.014
CHEMBL247699 100602 0 None -2 2 Human 7.8 pEC50 = 7.8 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@@H]2C[C@@H](COP(=O)(O)O)N[C@H]2CO)cc1 10.1016/j.bmcl.2006.10.014
44547414 75118 0 None -123 6 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant human S1P4 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assayAgonist activity at recombinant human S1P4 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assay
ChEMBL 499 5 1 5 5.2 O=C(O)CCC(=O)N1CCc2cc(-c3noc(-c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)ccc21 10.1016/j.bmcl.2011.05.110
CHEMBL1916559 75118 0 None -123 6 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant human S1P4 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assayAgonist activity at recombinant human S1P4 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assay
ChEMBL 499 5 1 5 5.2 O=C(O)CCC(=O)N1CCc2cc(-c3noc(-c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)ccc21 10.1016/j.bmcl.2011.05.110
57398995 74674 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 343 2 0 4 3.8 C/N=C1\S/C(=C\c2cc(C)n(-c3cccc(F)c3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910673 74674 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 343 2 0 4 3.8 C/N=C1\S/C(=C\c2cc(C)n(-c3cccc(F)c3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
58344526 156907 4 None -10232 5 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 404 7 2 7 3.6 CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NCCO)no2)cc1C#N nan
CHEMBL3951270 156907 4 None -10232 5 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 404 7 2 7 3.6 CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NCCO)no2)cc1C#N nan
4780551 32154 7 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 342 6 0 5 4.1 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1349615 32154 7 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 342 6 0 5 4.1 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
4780551 32154 7 None - 1 Human 6.8 pEC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 342 6 0 5 4.1 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 nan
CHEMBL1349615 32154 7 None - 1 Human 6.8 pEC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 342 6 0 5 4.1 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 nan
10883396 10421 45 None -21 15 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assayAgonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm100181s
5283560 10421 45 None -21 15 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assayAgonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm100181s
911 10421 45 None -21 15 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assayAgonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm100181s
CHEMBL225155 10421 45 None -21 15 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assayAgonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm100181s
44422604 92223 0 None -81 5 Human 6.8 pEC50 = 6.8 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 432 15 4 4 4.4 CCCCCCCCCCc1ccc(NC(=O)[C@H](N)CC(F)OP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
CHEMBL226612 92223 0 None -81 5 Human 6.8 pEC50 = 6.8 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 432 15 4 4 4.4 CCCCCCCCCCc1ccc(NC(=O)[C@H](N)CC(F)OP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
49835990 74691 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 405 5 0 5 3.9 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3F)c2C)C(=O)N1CCOC 10.1016/j.bmcl.2011.09.049
CHEMBL1910791 74691 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 405 5 0 5 3.9 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3F)c2C)C(=O)N1CCOC 10.1016/j.bmcl.2011.09.049
46881912 13538 0 None -3 4 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 425 13 2 5 2.8 CCCCCCCOc1ccc(CC[C@](C)(N)CCN2CC(=O)NS2(=O)=O)cc1 10.1016/j.bmcl.2010.01.118
CHEMBL1083841 13538 0 None -3 4 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 425 13 2 5 2.8 CCCCCCCOc1ccc(CC[C@](C)(N)CCN2CC(=O)NS2(=O)=O)cc1 10.1016/j.bmcl.2010.01.118
11222939 74349 9 None -12 4 Human 7.7 pEC50 = 7.7 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1016/j.bmcl.2006.10.014
44438254 74349 9 None -12 4 Human 7.7 pEC50 = 7.7 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1016/j.bmcl.2006.10.014
CHEMBL190006 74349 9 None -12 4 Human 7.7 pEC50 = 7.7 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1016/j.bmcl.2006.10.014
57397318 74680 1 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 326 2 0 5 3.0 C/N=C1\S/C(=C\c2cc(C)n(-c3ccccn3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910682 74680 1 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 326 2 0 5 3.0 C/N=C1\S/C(=C\c2cc(C)n(-c3ccccn3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
57393539 76195 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 345 6 0 4 4.3 O=Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1933158 76195 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 345 6 0 4 4.3 O=Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 10.1016/j.bmcl.2011.10.096
5398663 52616 20 None 1 3 Human 5.7 pEC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 285 3 2 5 2.0 O=C(NCc1ccco1)c1cc2ccc(O)cc2oc1=O nan
CHEMBL1531320 52616 20 None 1 3 Human 5.7 pEC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 285 3 2 5 2.0 O=C(NCc1ccco1)c1cc2ccc(O)cc2oc1=O nan
5392139 52539 67 None 2 2 Human 5.7 pEC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 204 1 1 4 1.7 CC(=O)c1cc2ccc(O)cc2oc1=O nan
CHEMBL153064 52539 67 None 2 2 Human 5.7 pEC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 204 1 1 4 1.7 CC(=O)c1cc2ccc(O)cc2oc1=O nan
46881875 14102 0 None 1 4 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 371 13 3 3 4.3 CCCCCCCOc1ccc(CC[C@](C)(N)CCP(=O)(O)O)cc1 10.1016/j.bmcl.2010.01.118
CHEMBL1086170 14102 0 None 1 4 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 371 13 3 3 4.3 CCCCCCCOc1ccc(CC[C@](C)(N)CCP(=O)(O)O)cc1 10.1016/j.bmcl.2010.01.118
44406749 81811 0 None -1 3 Human 7.7 pEC50 = 7.7 Functional
Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 565 18 4 10 4.7 C[C@@](N)(CCc1ccc(OCCCCCCCCNc2ccc([N+](=O)[O-])c3nonc23)cc1)COP(=O)(O)O 10.1016/j.bmcl.2005.09.038
CHEMBL203475 81811 0 None -1 3 Human 7.7 pEC50 = 7.7 Functional
Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 565 18 4 10 4.7 C[C@@](N)(CCc1ccc(OCCCCCCCCNc2ccc([N+](=O)[O-])c3nonc23)cc1)COP(=O)(O)O 10.1016/j.bmcl.2005.09.038
11452022 10368 39 None -26 6 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human S1P4 expressed in CHO-K1 aequorin cells assessed as calcium accumulation of by luminescence assay in presence of cofactor coelenterazineAgonist activity at human S1P4 expressed in CHO-K1 aequorin cells assessed as calcium accumulation of by luminescence assay in presence of cofactor coelenterazine
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/jm200609t
6996 10368 39 None -26 6 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human S1P4 expressed in CHO-K1 aequorin cells assessed as calcium accumulation of by luminescence assay in presence of cofactor coelenterazineAgonist activity at human S1P4 expressed in CHO-K1 aequorin cells assessed as calcium accumulation of by luminescence assay in presence of cofactor coelenterazine
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/jm200609t
CHEMBL366208 10368 39 None -26 6 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human S1P4 expressed in CHO-K1 aequorin cells assessed as calcium accumulation of by luminescence assay in presence of cofactor coelenterazineAgonist activity at human S1P4 expressed in CHO-K1 aequorin cells assessed as calcium accumulation of by luminescence assay in presence of cofactor coelenterazine
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/jm200609t
2924 8421 43 None -6 7 Human 8.6 pEC50 = 8.6 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/jm050242f
44398069 8421 43 None -6 7 Human 8.6 pEC50 = 8.6 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/jm050242f
9908268 8421 43 None -6 7 Human 8.6 pEC50 = 8.6 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/jm050242f
CHEMBL114606 8421 43 None -6 7 Human 8.6 pEC50 = 8.6 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/jm050242f
1776080 74668 7 None 3 3 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 343 2 0 4 3.8 C/N=C1\S/C(=C\c2cc(C)n(-c3ccccc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910655 74668 7 None 3 3 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 343 2 0 4 3.8 C/N=C1\S/C(=C\c2cc(C)n(-c3ccccc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
3879894 54039 6 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 352 6 0 5 3.5 Cc1ccc(OCCOc2ccc(Br)cc2)c([N+](=O)[O-])n1 nan
CHEMBL1543937 54039 6 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 352 6 0 5 3.5 Cc1ccc(OCCOc2ccc(Br)cc2)c([N+](=O)[O-])n1 nan
57393538 76189 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 379 5 0 3 4.7 Fc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Br)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1933150 76189 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 379 5 0 3 4.7 Fc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Br)n1 10.1016/j.bmcl.2011.10.096
57392027 74677 0 None 21 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 361 2 0 4 3.9 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910678 74677 0 None 21 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 361 2 0 4 3.9 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
136042189 74671 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 392 3 1 5 4.5 Cc1cc(/C=C2\S/C(=N\c3ccccn3)NC2=O)c(C)n1-c1ccccc1F 10.1016/j.bmcl.2011.09.049
CHEMBL1910660 74671 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 392 3 1 5 4.5 Cc1cc(/C=C2\S/C(=N\c3ccccn3)NC2=O)c(C)n1-c1ccccc1F 10.1016/j.bmcl.2011.09.049
57398795 76193 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 437 6 0 4 4.3 O=Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(I)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1933156 76193 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 437 6 0 4 4.3 O=Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(I)n1 10.1016/j.bmcl.2011.10.096
44620887 66263 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 326 5 0 4 4.2 Cc1ccc(OCCc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 nan
CHEMBL1714368 66263 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 326 5 0 4 4.2 Cc1ccc(OCCc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 nan
11452022 10368 39 None -26 6 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human S1P4 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assayAgonist activity at recombinant human S1P4 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/acsmedchemlett.0c00631
6996 10368 39 None -26 6 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human S1P4 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assayAgonist activity at recombinant human S1P4 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/acsmedchemlett.0c00631
CHEMBL366208 10368 39 None -26 6 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human S1P4 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assayAgonist activity at recombinant human S1P4 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1021/acsmedchemlett.0c00631
11452022 10368 39 None -26 6 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2010.02.006
6996 10368 39 None -26 6 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2010.02.006
CHEMBL366208 10368 39 None -26 6 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2010.02.006
57403951 76535 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 386 6 0 5 4.2 Cc1ccc(OCCOc2ccc(Br)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1935674 76535 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 386 6 0 5 4.2 Cc1ccc(OCCOc2ccc(Br)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
44422601 92356 0 None -63 5 Human 6.6 pEC50 = 6.6 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 398 14 4 3 4.2 CCCCCCCCCCc1ccc(NC(=O)[C@H](N)CCP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
CHEMBL228139 92356 0 None -63 5 Human 6.6 pEC50 = 6.6 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 398 14 4 3 4.2 CCCCCCCCCCc1ccc(NC(=O)[C@H](N)CCP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
44422573 92331 0 None -85 4 Human 5.6 pEC50 = 5.6 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 370 12 4 3 3.4 CCCCCCCCc1ccc(NC(=O)[C@H](N)CCP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
CHEMBL227851 92331 0 None -85 4 Human 5.6 pEC50 = 5.6 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 370 12 4 3 3.4 CCCCCCCCc1ccc(NC(=O)[C@H](N)CCP(=O)(O)O)cc1 10.1016/j.bmc.2006.10.060
33291425 76534 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 386 6 0 5 4.2 Cc1ccc(OCCOc2ccc(Cl)cc2Br)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1935673 76534 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 386 6 0 5 4.2 Cc1ccc(OCCOc2ccc(Cl)cc2Br)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
3879894 54039 6 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 352 6 0 5 3.5 Cc1ccc(OCCOc2ccc(Br)cc2)c([N+](=O)[O-])n1 nan
CHEMBL1543937 54039 6 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 352 6 0 5 3.5 Cc1ccc(OCCOc2ccc(Br)cc2)c([N+](=O)[O-])n1 nan
42630194 82552 0 None -208 5 Human 6.6 pEC50 = 6.6 Functional
Agonist activity against human S1P4 by beta arrestin recruitment assayAgonist activity against human S1P4 by beta arrestin recruitment assay
ChEMBL 468 5 2 6 5.2 N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4[nH]c5c(c4c3)CCC5CC(=O)O)no2)c1 10.1016/j.bmcl.2012.04.129
CHEMBL2048287 82552 0 None -208 5 Human 6.6 pEC50 = 6.6 Functional
Agonist activity against human S1P4 by beta arrestin recruitment assayAgonist activity against human S1P4 by beta arrestin recruitment assay
ChEMBL 468 5 2 6 5.2 N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4[nH]c5c(c4c3)CCC5CC(=O)O)no2)c1 10.1016/j.bmcl.2012.04.129
49835930 74672 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 371 4 0 4 4.5 CC/N=C1\S/C(=C\c2cc(C)n(-c3ccccc3F)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
CHEMBL1910662 74672 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 371 4 0 4 4.5 CC/N=C1\S/C(=C\c2cc(C)n(-c3ccccc3F)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
3536865 53811 5 None - 1 Human 5.6 pEC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 426 6 2 6 2.9 CCNC(=O)NC(=O)C(C)OC(=O)c1c(C)nn(Cc2ccccc2Cl)c1Cl nan
CHEMBL1541924 53811 5 None - 1 Human 5.6 pEC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 426 6 2 6 2.9 CCNC(=O)NC(=O)C(C)OC(=O)c1c(C)nn(Cc2ccccc2Cl)c1Cl nan
9550812 31289 9 None 2 3 Human 5.6 pEC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 328 1 0 6 2.2 Cc1ccccc1-n1c(=O)c(C#N)cc2c(=O)n3ccccc3nc21 nan
CHEMBL1342332 31289 9 None 2 3 Human 5.6 pEC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 328 1 0 6 2.2 Cc1ccccc1-n1c(=O)c(C#N)cc2c(=O)n3ccccc3nc21 nan
57403952 76538 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 326 6 0 5 3.5 Cc1ccc(OCCOc2ccc(F)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1935678 76538 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 326 6 0 5 3.5 Cc1ccc(OCCOc2ccc(F)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
57393480 76546 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 311 5 0 3 4.5 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(C)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1935696 76546 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 311 5 0 3 4.5 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(C)n1 10.1016/j.bmcl.2011.10.096
57390239 74683 0 None -1 4 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 339 3 0 4 3.7 C/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910687 74683 0 None -1 4 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 339 3 0 4 3.7 C/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
57400709 74670 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 405 3 0 4 5.5 Cc1cc(/C=C2\S/C(=N\c3ccccc3)N(C)C2=O)c(C)n1-c1ccccc1F 10.1016/j.bmcl.2011.09.049
CHEMBL1910658 74670 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 405 3 0 4 5.5 Cc1cc(/C=C2\S/C(=N\c3ccccc3)N(C)C2=O)c(C)n1-c1ccccc1F 10.1016/j.bmcl.2011.09.049
57395199 76539 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 337 7 0 7 2.8 Cc1ccc(OCCOc2ccc([N+](=O)[O-])cc2F)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1935680 76539 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 337 7 0 7 2.8 Cc1ccc(OCCOc2ccc([N+](=O)[O-])cc2F)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
57395254 76192 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 439 6 1 4 3.9 OCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(I)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1933155 76192 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 439 6 1 4 3.9 OCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(I)n1 10.1016/j.bmcl.2011.10.096
16193872 35248 9 None 3 2 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 348 1 0 6 2.5 N#Cc1cc2c(=O)n3ccccc3nc2n(-c2ccccc2Cl)c1=O nan
CHEMBL1375597 35248 9 None 3 2 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 348 1 0 6 2.5 N#Cc1cc2c(=O)n3ccccc3nc2n(-c2ccccc2Cl)c1=O nan
44620883 66605 2 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 328 6 0 5 3.8 O=[N+]([O-])c1ncccc1OCCOc1ccc(Cl)cc1Cl 10.1016/j.bmcl.2011.10.096
CHEMBL1728130 66605 2 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 328 6 0 5 3.8 O=[N+]([O-])c1ncccc1OCCOc1ccc(Cl)cc1Cl 10.1016/j.bmcl.2011.10.096
44620883 66605 2 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 328 6 0 5 3.8 O=[N+]([O-])c1ncccc1OCCOc1ccc(Cl)cc1Cl nan
CHEMBL1728130 66605 2 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 328 6 0 5 3.8 O=[N+]([O-])c1ncccc1OCCOc1ccc(Cl)cc1Cl nan
118877433 184119 0 None -14 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay
ChEMBL 459 8 3 4 4.5 COc1ccccc1CC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.8b01695
CHEMBL4637401 184119 0 None -14 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay
ChEMBL 459 8 3 4 4.5 COc1ccccc1CC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.8b01695
59384375 111167 0 None -8 3 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting
ChEMBL 510 13 3 6 5.9 CCCCCCCCOc1ccc(-c2cnc([C@@](C)(N)COP(=O)(O)O)s2)cc1C(F)(F)F 10.1021/ml400194r
CHEMBL3102903 111167 0 None -8 3 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting
ChEMBL 510 13 3 6 5.9 CCCCCCCCOc1ccc(-c2cnc([C@@](C)(N)COP(=O)(O)O)s2)cc1C(F)(F)F 10.1021/ml400194r
57400397 76544 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 362 6 0 5 4.4 O=[N+]([O-])c1nc(Cl)ccc1OCCOc1ccc(Cl)cc1Cl 10.1016/j.bmcl.2011.10.096
CHEMBL1935690 76544 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 362 6 0 5 4.4 O=[N+]([O-])c1nc(Cl)ccc1OCCOc1ccc(Cl)cc1Cl 10.1016/j.bmcl.2011.10.096
57397316 74673 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 373 4 1 5 3.1 Cc1cc(/C=C2\S/C(=N\CCO)N(C)C2=O)c(C)n1-c1ccccc1F 10.1016/j.bmcl.2011.09.049
CHEMBL1910663 74673 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 373 4 1 5 3.1 Cc1cc(/C=C2\S/C(=N\CCO)N(C)C2=O)c(C)n1-c1ccccc1F 10.1016/j.bmcl.2011.09.049
57392028 74681 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 344 2 0 5 3.2 C/N=C1\S/C(=C\c2cc(C)n(-c3ncccc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910685 74681 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 344 2 0 5 3.2 C/N=C1\S/C(=C\c2cc(C)n(-c3ncccc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
57395198 76537 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 326 6 0 5 3.5 Cc1ccc(OCCOc2ccc(Cl)cc2F)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1935677 76537 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 326 6 0 5 3.5 Cc1ccc(OCCOc2ccc(Cl)cc2F)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
57397321 74686 0 None -17 3 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 403 5 0 4 4.7 CC/N=C1\S/C(=C\c2cc(C)n(Cc3c(F)cccc3F)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
CHEMBL1910690 74686 0 None -17 3 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 403 5 0 4 4.7 CC/N=C1\S/C(=C\c2cc(C)n(Cc3c(F)cccc3F)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
57400712 74676 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 368 2 0 5 3.6 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)c(C#N)c3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910675 74676 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 368 2 0 5 3.6 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)c(C#N)c3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
2063413 32416 30 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 256 2 0 4 3.1 N#Cc1c(-n2cccc2C=O)sc2c1CCCC2 nan
CHEMBL1351890 32416 30 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 256 2 0 4 3.1 N#Cc1c(-n2cccc2C=O)sc2c1CCCC2 nan
25110406 8079 53 None -1698 4 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 409 9 2 7 3.8 OCCNC1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)OCC)OCC nan
2928 8079 53 None -1698 4 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 409 9 2 7 3.8 OCCNC1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)OCC)OCC nan
CHEMBL3922179 8079 53 None -1698 4 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 409 9 2 7 3.8 OCCNC1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)OCC)OCC nan
44438261 100635 0 None -1 2 Human 7.5 pEC50 = 7.5 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@@H]2C[C@@H](CO)N[C@H]2COP(=O)(O)O)cc1 10.1016/j.bmcl.2006.10.014
44438262 100635 0 None -1 2 Human 7.5 pEC50 = 7.5 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@@H]2C[C@@H](CO)N[C@H]2COP(=O)(O)O)cc1 10.1016/j.bmcl.2006.10.014
CHEMBL247901 100635 0 None -1 2 Human 7.5 pEC50 = 7.5 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@@H]2C[C@@H](CO)N[C@H]2COP(=O)(O)O)cc1 10.1016/j.bmcl.2006.10.014
2864688 43208 9 None -3 5 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 473 4 1 4 4.6 NS(=O)(=O)c1ccc(N2N=C(c3ccc(Br)cc3)CC2c2ccc(F)cc2)cc1 nan
CHEMBL1447076 43208 9 None -3 5 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 473 4 1 4 4.6 NS(=O)(=O)c1ccc(N2N=C(c3ccc(Br)cc3)CC2c2ccc(F)cc2)cc1 nan
44422579 92355 0 None -11 3 Human 6.5 pEC50 = 6.5 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 356 13 4 3 3.9 CCCCCCCCc1cccc(NC[C@H](N)CCP(=O)(O)O)c1 10.1016/j.bmc.2006.10.060
CHEMBL228138 92355 0 None -11 3 Human 6.5 pEC50 = 6.5 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 356 13 4 3 3.9 CCCCCCCCc1cccc(NC[C@H](N)CCP(=O)(O)O)c1 10.1016/j.bmc.2006.10.060
44438257 100601 0 None -2 2 Human 6.5 pEC50 = 6.5 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@H]2C[C@H](CO)N[C@@H]2COP(=O)(O)O)cc1 10.1016/j.bmcl.2006.10.014
44438258 100601 0 None -2 2 Human 6.5 pEC50 = 6.5 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@H]2C[C@H](CO)N[C@@H]2COP(=O)(O)O)cc1 10.1016/j.bmcl.2006.10.014
CHEMBL247698 100601 0 None -2 2 Human 6.5 pEC50 = 6.5 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@H]2C[C@H](CO)N[C@@H]2COP(=O)(O)O)cc1 10.1016/j.bmcl.2006.10.014
57391736 76540 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 353 7 0 7 3.3 Cc1ccc(OCCOc2cc(Cl)cc([N+](=O)[O-])c2)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1935681 76540 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 353 7 0 7 3.3 Cc1ccc(OCCOc2cc(Cl)cc([N+](=O)[O-])c2)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
136212602 18525 8 None -4 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 369 11 4 4 3.6 CCCCCCCCc1ccc2nc([C@@H](N)COP(=O)(O)O)[nH]c2c1 10.1016/j.bmcl.2011.09.049
44394498 18525 8 None -4 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 369 11 4 4 3.6 CCCCCCCCc1ccc2nc([C@@H](N)COP(=O)(O)O)[nH]c2c1 10.1016/j.bmcl.2011.09.049
CHEMBL1181619 18525 8 None -4 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 369 11 4 4 3.6 CCCCCCCCc1ccc2nc([C@@H](N)COP(=O)(O)O)[nH]c2c1 10.1016/j.bmcl.2011.09.049
CHEMBL1910653 18525 8 None -4 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 369 11 4 4 3.6 CCCCCCCCc1ccc2nc([C@@H](N)COP(=O)(O)O)[nH]c2c1 10.1016/j.bmcl.2011.09.049
136042188 74669 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 329 2 1 4 3.4 C/N=C1/NC(=O)/C(=C/c2cc(C)n(-c3ccccc3F)c2C)S1 10.1016/j.bmcl.2011.09.049
CHEMBL1910656 74669 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 329 2 1 4 3.4 C/N=C1/NC(=O)/C(=C/c2cc(C)n(-c3ccccc3F)c2C)S1 10.1016/j.bmcl.2011.09.049
3418421 66059 6 None - 1 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 355 5 1 5 3.6 Cc1ccc(OCC(=O)Nc2cc(Cl)cc(Cl)c2)c([N+](=O)[O-])n1 nan
CHEMBL1704790 66059 6 None - 1 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]PUBCHEM_BIOASSAY: Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801]
ChEMBL 355 5 1 5 3.6 Cc1ccc(OCC(=O)Nc2cc(Cl)cc(Cl)c2)c([N+](=O)[O-])n1 nan
3093171 52852 13 None -1 4 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 423 8 2 6 1.9 O=S(=O)(c1ccc(N2CCC(c3ccc(Cl)cc3)=N2)cc1)N(CCO)CCO nan
CHEMBL1533401 52852 13 None -1 4 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 423 8 2 6 1.9 O=S(=O)(c1ccc(N2CCC(c3ccc(Cl)cc3)=N2)cc1)N(CCO)CCO nan
1522831 44329 18 None -1 2 Human 4.4 pEC50 = 4.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 376 2 0 6 4.3 Cn1c(-c2cc3ccc(OC(=O)C(C)(C)C)cc3oc2=O)nc2ccccc21 nan
CHEMBL1456255 44329 18 None -1 2 Human 4.4 pEC50 = 4.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 376 2 0 6 4.3 Cn1c(-c2cc3ccc(OC(=O)C(C)(C)C)cc3oc2=O)nc2ccccc21 nan
665934 49515 11 None 2 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 335 1 0 8 1.6 Cc1ccc2nc3c(cc(C#N)c(=O)n3-c3nccs3)c(=O)n2c1 nan
CHEMBL1501839 49515 11 None 2 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 335 1 0 8 1.6 Cc1ccc2nc3c(cc(C#N)c(=O)n3-c3nccs3)c(=O)n2c1 nan
136042186 74693 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 316 2 1 5 2.5 C/N=C1/NC(=O)/C(=C/c2cnn(-c3ccc(F)cc3)c2C)S1 10.1016/j.bmcl.2011.09.049
CHEMBL1910794 74693 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 316 2 1 5 2.5 C/N=C1/NC(=O)/C(=C/c2cnn(-c3ccc(F)cc3)c2C)S1 10.1016/j.bmcl.2011.09.049
44620884 66475 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 338 7 0 6 3.4 COc1ccc(OCCOc2ccc(C)nc2[N+](=O)[O-])c(Cl)c1 10.1016/j.bmcl.2011.10.096
CHEMBL1723135 66475 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 338 7 0 6 3.4 COc1ccc(OCCOc2ccc(C)nc2[N+](=O)[O-])c(Cl)c1 10.1016/j.bmcl.2011.10.096
44620884 66475 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 338 7 0 6 3.4 COc1ccc(OCCOc2ccc(C)nc2[N+](=O)[O-])c(Cl)c1 nan
CHEMBL1723135 66475 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 338 7 0 6 3.4 COc1ccc(OCCOc2ccc(C)nc2[N+](=O)[O-])c(Cl)c1 nan
57390242 74696 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 369 5 1 5 3.0 Cc1cc(/C=C2\S/C(=N\CCO)N(C)C2=O)c(C)n1Cc1ccccc1 10.1016/j.bmcl.2011.09.049
CHEMBL1910801 74696 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 369 5 1 5 3.0 Cc1cc(/C=C2\S/C(=N\CCO)N(C)C2=O)c(C)n1Cc1ccccc1 10.1016/j.bmcl.2011.09.049
2924 8421 43 None -6 7 Human 8.4 pEC50 = 8.4 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmc.2006.10.060
44398069 8421 43 None -6 7 Human 8.4 pEC50 = 8.4 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmc.2006.10.060
9908268 8421 43 None -6 7 Human 8.4 pEC50 = 8.4 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmc.2006.10.060
CHEMBL114606 8421 43 None -6 7 Human 8.4 pEC50 = 8.4 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmc.2006.10.060
59384310 111168 0 None -17 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting
ChEMBL 511 13 3 7 5.2 CCCCCCCCOc1ccc(-c2nnc([C@@](C)(N)COP(=O)(O)O)s2)cc1C(F)(F)F 10.1021/ml400194r
CHEMBL3102904 111168 0 None -17 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P4R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting
ChEMBL 511 13 3 7 5.2 CCCCCCCCOc1ccc(-c2nnc([C@@](C)(N)COP(=O)(O)O)s2)cc1C(F)(F)F 10.1021/ml400194r
9550767 31151 9 None 2 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 328 1 0 6 2.2 Cc1cccc(-n2c(=O)c(C#N)cc3c(=O)n4ccccc4nc32)c1 nan
CHEMBL1341200 31151 9 None 2 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 328 1 0 6 2.2 Cc1cccc(-n2c(=O)c(C#N)cc3c(=O)n4ccccc4nc32)c1 nan
25192001 14831 0 None -9 4 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 413 12 4 4 3.5 CCCCCCCCc1ccc2c(c1)CC[C@@H](C(N)(CO)COP(=O)(O)O)C2 10.1016/j.bmcl.2010.02.006
CHEMBL1091103 14831 0 None -9 4 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 413 12 4 4 3.5 CCCCCCCCc1ccc2c(c1)CC[C@@H](C(N)(CO)COP(=O)(O)O)C2 10.1016/j.bmcl.2010.02.006
52938427 9758 55 None -1174 5 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C nan
5383 9758 55 None -1174 5 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C nan
8709 9758 55 None -1174 5 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C nan
CHEMBL3707247 9758 55 None -1174 5 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C nan
DB12612 9758 55 None -1174 5 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C nan
57398996 74675 1 None 1 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 343 2 0 4 3.8 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910674 74675 1 None 1 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 343 2 0 4 3.8 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
1132552 53266 6 None -3 2 Human 4.4 pEC50 = 4.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 357 3 1 5 4.0 COc1ccc(-c2c(C#N)c(N)nc3c2CCc2ccccc2-3)cc1OC nan
CHEMBL1537481 53266 6 None -3 2 Human 4.4 pEC50 = 4.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 357 3 1 5 4.0 COc1ccc(-c2c(C#N)c(N)nc3c2CCc2ccccc2-3)cc1OC nan
57390238 74678 0 None 6 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 377 2 0 4 4.4 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(Cl)cc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910680 74678 0 None 6 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 377 2 0 4 4.4 C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(Cl)cc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
5296049 57623 12 None -1 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 304 2 1 1 5.5 Clc1ccc(/C=C\c2[nH]ccc3c4ccccc4nc2-3)cc1 nan
CHEMBL1577139 57623 12 None -1 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 304 2 1 1 5.5 Clc1ccc(/C=C\c2[nH]ccc3c4ccccc4nc2-3)cc1 nan
665938 33497 11 None 2 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 319 1 0 8 1.2 Cc1cc(-n2c(=O)c(C#N)cc3c(=O)n4ccccc4nc32)no1 nan
CHEMBL1362307 33497 11 None 2 2 Human 5.4 pEC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 319 1 0 8 1.2 Cc1cc(-n2c(=O)c(C#N)cc3c(=O)n4ccccc4nc32)no1 nan
44620894 66406 27 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 349 6 0 3 5.0 FCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1720563 66406 27 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 349 6 0 3 5.0 FCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 10.1016/j.bmcl.2011.10.096
44620894 66406 27 None - 1 Human 7.3 pEC50 = 7.3 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 349 6 0 3 5.0 FCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 nan
CHEMBL1720563 66406 27 None - 1 Human 7.3 pEC50 = 7.3 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 349 6 0 3 5.0 FCc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 nan
44620892 66725 28 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 439 5 0 3 5.4 Clc1ccc(OCCOc2ccc(Br)nc2Br)c(Cl)c1 10.1016/j.bmcl.2011.10.096
CHEMBL1732549 66725 28 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 439 5 0 3 5.4 Clc1ccc(OCCOc2ccc(Br)nc2Br)c(Cl)c1 10.1016/j.bmcl.2011.10.096
44620892 66725 28 None - 1 Human 7.3 pEC50 = 7.3 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 439 5 0 3 5.4 Clc1ccc(OCCOc2ccc(Br)nc2Br)c(Cl)c1 nan
CHEMBL1732549 66725 28 None - 1 Human 7.3 pEC50 = 7.3 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 439 5 0 3 5.4 Clc1ccc(OCCOc2ccc(Br)nc2Br)c(Cl)c1 nan
42630194 82552 0 None -208 5 Human 6.3 pEC50 = 6.3 Functional
Agonist activity against human S1P4 by beta arrestin recruitment assayAgonist activity against human S1P4 by beta arrestin recruitment assay
ChEMBL 468 5 2 6 5.2 N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4[nH]c5c(c4c3)CCC5CC(=O)O)no2)c1 10.1016/j.bmcl.2012.04.129
CHEMBL2048287 82552 0 None -208 5 Human 6.3 pEC50 = 6.3 Functional
Agonist activity against human S1P4 by beta arrestin recruitment assayAgonist activity against human S1P4 by beta arrestin recruitment assay
ChEMBL 468 5 2 6 5.2 N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4[nH]c5c(c4c3)CCC5CC(=O)O)no2)c1 10.1016/j.bmcl.2012.04.129
57402197 76545 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 355 6 0 5 3.9 COC(=O)c1nc(C)ccc1OCCOc1ccc(Cl)cc1Cl 10.1016/j.bmcl.2011.10.096
CHEMBL1935691 76545 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 355 6 0 5 3.9 COC(=O)c1nc(C)ccc1OCCOc1ccc(Cl)cc1Cl 10.1016/j.bmcl.2011.10.096
4300117 33662 6 None - 1 Human 4.3 pEC50 = 4.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 392 6 2 6 2.3 CCNC(=O)NC(=O)C(C)OC(=O)c1c(C)nn(Cc2ccccc2)c1Cl nan
CHEMBL1363676 33662 6 None - 1 Human 4.3 pEC50 = 4.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 392 6 2 6 2.3 CCNC(=O)NC(=O)C(C)OC(=O)c1c(C)nn(Cc2ccccc2)c1Cl nan
25192001 14831 0 None -9 4 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 413 12 4 4 3.5 CCCCCCCCc1ccc2c(c1)CC[C@@H](C(N)(CO)COP(=O)(O)O)C2 10.1016/j.bmcl.2010.02.006
CHEMBL1091103 14831 0 None -9 4 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
ChEMBL 413 12 4 4 3.5 CCCCCCCCc1ccc2c(c1)CC[C@@H](C(N)(CO)COP(=O)(O)O)C2 10.1016/j.bmcl.2010.02.006
118877603 187208 0 None -6 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 425 10 3 4 4.1 COCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.0c01109
CHEMBL4752394 187208 0 None -6 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method
ChEMBL 425 10 3 4 4.1 COCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 10.1021/acs.jmedchem.0c01109
46881847 13830 0 None -6 4 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 373 13 3 4 3.8 CCCCCCCOc1ccc(CC[C@](C)(N)COP(=O)(O)O)cc1 10.1016/j.bmcl.2010.01.118
CHEMBL1084929 13830 0 None -6 4 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 373 13 3 4 3.8 CCCCCCCOc1ccc(CC[C@](C)(N)COP(=O)(O)O)cc1 10.1016/j.bmcl.2010.01.118
11588811 10784 45 None -9 4 Human 6.3 pEC50 = 6.3 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1cccc(c1)NC(=O)[C@@H](COP(=O)(O)O)N 10.1016/j.bmc.2006.10.060
136212600 10784 45 None -9 4 Human 6.3 pEC50 = 6.3 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1cccc(c1)NC(=O)[C@@H](COP(=O)(O)O)N 10.1016/j.bmc.2006.10.060
3324 10784 45 None -9 4 Human 6.3 pEC50 = 6.3 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1cccc(c1)NC(=O)[C@@H](COP(=O)(O)O)N 10.1016/j.bmc.2006.10.060
CHEMBL228102 10784 45 None -9 4 Human 6.3 pEC50 = 6.3 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1cccc(c1)NC(=O)[C@@H](COP(=O)(O)O)N 10.1016/j.bmc.2006.10.060
44620895 66446 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 375 5 0 3 4.9 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Br)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1722064 66446 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 375 5 0 3 4.9 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Br)n1 10.1016/j.bmcl.2011.10.096
44620895 66446 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 375 5 0 3 4.9 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Br)n1 nan
CHEMBL1722064 66446 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 375 5 0 3 4.9 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Br)n1 nan
16196388 60588 0 None 4 2 Human 5.3 pEC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 372 8 3 5 1.7 CNC(=O)c1[nH]cnc1C(=O)N[C@@H](CC(C)C)C(=O)OCc1ccccc1 nan
CHEMBL1604216 60588 0 None 4 2 Human 5.3 pEC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 372 8 3 5 1.7 CNC(=O)c1[nH]cnc1C(=O)N[C@@H](CC(C)C)C(=O)OCc1ccccc1 nan
4780551 32154 7 None - 1 Human 6.3 pEC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 342 6 0 5 4.1 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 nan
CHEMBL1349615 32154 7 None - 1 Human 6.3 pEC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 342 6 0 5 4.1 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 nan
56835136 76190 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 423 5 0 3 4.8 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(I)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1933151 76190 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 423 5 0 3 4.8 Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(I)n1 10.1016/j.bmcl.2011.10.096
57397319 74682 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 372 4 0 5 3.9 CC/N=C1\S/C(=C\c2cc(C)n(-c3ncccc3F)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
CHEMBL1910686 74682 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 372 4 0 5 3.9 CC/N=C1\S/C(=C\c2cc(C)n(-c3ncccc3F)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
57402195 76536 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 338 7 0 6 3.4 COc1cc(Cl)ccc1OCCOc1ccc(C)nc1[N+](=O)[O-] 10.1016/j.bmcl.2011.10.096
CHEMBL1935675 76536 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 338 7 0 6 3.4 COc1cc(Cl)ccc1OCCOc1ccc(C)nc1[N+](=O)[O-] 10.1016/j.bmcl.2011.10.096
25110382 152887 0 None -34673 5 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 366 6 1 6 4.2 CCOc1ccc(-c2nc(-c3cccc4c3CCC4O)no2)cc1OCC nan
CHEMBL3919445 152887 0 None -34673 5 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 366 6 1 6 4.2 CCOc1ccc(-c2nc(-c3cccc4c3CCC4O)no2)cc1OCC nan
10311 8076 37 None 37 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 405 5 0 5 3.9 COCCN=C1S/C(=C\c2cc(n(c2C)c2ccc(cc2F)F)C)/C(=O)N1C 10.1016/j.bmcl.2011.09.049
49835928 8076 37 None 37 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 405 5 0 5 3.9 COCCN=C1S/C(=C\c2cc(n(c2C)c2ccc(cc2F)F)C)/C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910803 8076 37 None 37 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 405 5 0 5 3.9 COCCN=C1S/C(=C\c2cc(n(c2C)c2ccc(cc2F)F)C)/C(=O)N1C 10.1016/j.bmcl.2011.09.049
46224769 207621 0 None -281 4 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay
ChEMBL 331 2 1 3 4.3 Cc1nn(C(=O)/C=C/c2cccc3[nH]ccc23)c2c1[C@H]1[C@@H](C2)C1(C)C 10.1016/j.bmcl.2009.11.045
CHEMBL601062 207621 0 None -281 4 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay
ChEMBL 331 2 1 3 4.3 Cc1nn(C(=O)/C=C/c2cccc3[nH]ccc23)c2c1[C@H]1[C@@H](C2)C1(C)C 10.1016/j.bmcl.2009.11.045
44620882 66479 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 376 6 0 5 4.7 Cc1ccc(OCCOc2c(Cl)cc(Cl)cc2Cl)c([N+](=O)[O-])n1 nan
CHEMBL1723233 66479 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 376 6 0 5 4.7 Cc1ccc(OCCOc2c(Cl)cc(Cl)cc2Cl)c([N+](=O)[O-])n1 nan
44620882 66479 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 376 6 0 5 4.7 Cc1ccc(OCCOc2c(Cl)cc(Cl)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1723233 66479 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 376 6 0 5 4.7 Cc1ccc(OCCOc2c(Cl)cc(Cl)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
647592 40204 17 None -1 4 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 401 5 2 6 2.7 CC(C)n1c(=N)c(C(=O)NCCc2ccccc2)cc2c(=O)n3ccccc3nc21 nan
CHEMBL1419836 40204 17 None -1 4 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 401 5 2 6 2.7 CC(C)n1c(=N)c(C(=O)NCCc2ccccc2)cc2c(=O)n3ccccc3nc21 nan
11977938 77685 30 None -38 4 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human S1P4 receptorAgonist activity at human S1P4 receptor
ChEMBL 461 8 1 7 5.3 CCc1cc(CN2CC(C(=O)O)C2)sc1-c1noc(-c2ccc(Oc3ccccc3)cc2)n1 10.1016/j.ejmech.2012.02.022
CHEMBL1951304 77685 30 None -38 4 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human S1P4 receptorAgonist activity at human S1P4 receptor
ChEMBL 461 8 1 7 5.3 CCc1cc(CN2CC(C(=O)O)C2)sc1-c1noc(-c2ccc(Oc3ccccc3)cc2)n1 10.1016/j.ejmech.2012.02.022
57398794 76191 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 437 6 0 3 6.3 Clc1ccc(OCCOc2ccc(-c3ccccc3)nc2Br)c(Cl)c1 10.1016/j.bmcl.2011.10.096
CHEMBL1933153 76191 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 437 6 0 3 6.3 Clc1ccc(OCCOc2ccc(-c3ccccc3)nc2Br)c(Cl)c1 10.1016/j.bmcl.2011.10.096
57396981 76541 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 420 6 0 5 4.5 Cc1ccc(OCCOc2ccc(Br)cc2C(F)(F)F)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1935682 76541 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 420 6 0 5 4.5 Cc1ccc(OCCOc2ccc(Br)cc2C(F)(F)F)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
49835989 74679 1 None -8 3 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 353 4 0 4 4.4 CC/N=C1\S/C(=C\c2cc(C)n(-c3ccccc3)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
CHEMBL1910681 74679 1 None -8 3 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 353 4 0 4 4.4 CC/N=C1\S/C(=C\c2cc(C)n(-c3ccccc3)c2C)C(=O)N1CC 10.1016/j.bmcl.2011.09.049
11545181 10787 6 None -229 3 Human 5.2 pEC50 = 5.2 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 370 12 4 3 3.4 CCCCCCCCc1cccc(c1)NC(=O)[C@@H](CCP(=O)(O)O)N 10.1016/j.bmc.2006.10.060
2930 10787 6 None -229 3 Human 5.2 pEC50 = 5.2 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 370 12 4 3 3.4 CCCCCCCCc1cccc(c1)NC(=O)[C@@H](CCP(=O)(O)O)N 10.1016/j.bmc.2006.10.060
CHEMBL389033 10787 6 None -229 3 Human 5.2 pEC50 = 5.2 Functional
Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assayActivity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay
ChEMBL 370 12 4 3 3.4 CCCCCCCCc1cccc(c1)NC(=O)[C@@H](CCP(=O)(O)O)N 10.1016/j.bmc.2006.10.060
3239161 26439 11 None 3 3 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 278 2 0 6 1.1 C=CCn1c(=O)c(C#N)cc2c(=O)n3ccccc3nc21 nan
CHEMBL1300662 26439 11 None 3 3 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 278 2 0 6 1.1 C=CCn1c(=O)c(C#N)cc2c(=O)n3ccccc3nc21 nan
44406009 79484 0 None -12 4 Human 7.2 pEC50 = 7.2 Functional
Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 515 18 5 10 3.4 N[C@@H](COP(=O)(O)O)[C@H](O)/C=C/CCCCCCCCCCNc1ccc([N+](=O)[O-])c2nonc12 10.1016/j.bmcl.2005.09.038
CHEMBL199754 79484 0 None -12 4 Human 7.2 pEC50 = 7.2 Functional
Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay
ChEMBL 515 18 5 10 3.4 N[C@@H](COP(=O)(O)O)[C@H](O)/C=C/CCCCCCCCCCNc1ccc([N+](=O)[O-])c2nonc12 10.1016/j.bmcl.2005.09.038
57400467 76196 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 343 6 0 3 5.1 C=Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 10.1016/j.bmcl.2011.10.096
CHEMBL1933159 76196 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 343 6 0 3 5.1 C=Cc1ccc(OCCOc2ccc(Cl)cc2Cl)c(Cl)n1 10.1016/j.bmcl.2011.10.096
57398999 74688 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 353 4 0 4 3.9 C/N=C1\S/C(=C\c2cc(C)n(CCc3ccccc3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910692 74688 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 353 4 0 4 3.9 C/N=C1\S/C(=C\c2cc(C)n(CCc3ccccc3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
46881877 13877 0 None 1 4 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 359 13 2 5 3.8 CCCCCCCOc1ccc(CC[C@](C)(N)CCc2nnn[nH]2)cc1 10.1016/j.bmcl.2010.01.118
CHEMBL1085191 13877 0 None 1 4 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 359 13 2 5 3.8 CCCCCCCOc1ccc(CC[C@](C)(N)CCc2nnn[nH]2)cc1 10.1016/j.bmcl.2010.01.118
57390243 74697 0 None 2 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 383 6 0 5 3.7 COCC/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910802 74697 0 None 2 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 383 6 0 5 3.7 COCC/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
16215109 154286 0 None 1 2 Human 8.1 pEC50 = 8.1 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@H]2C[C@H](COP(=O)(O)O)N[C@@H]2CO)cc1 10.1016/j.bmcl.2006.10.014
44438256 154286 0 None 1 2 Human 8.1 pEC50 = 8.1 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@H]2C[C@H](COP(=O)(O)O)N[C@@H]2CO)cc1 10.1016/j.bmcl.2006.10.014
CHEMBL393055 154286 0 None 1 2 Human 8.1 pEC50 = 8.1 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@H]2C[C@H](COP(=O)(O)O)N[C@@H]2CO)cc1 10.1016/j.bmcl.2006.10.014
16215109 154286 0 None 1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@H]2C[C@H](COP(=O)(O)O)N[C@@H]2CO)cc1 10.1016/j.bmcl.2011.09.049
44438256 154286 0 None 1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@H]2C[C@H](COP(=O)(O)O)N[C@@H]2CO)cc1 10.1016/j.bmcl.2011.09.049
CHEMBL393055 154286 0 None 1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 399 12 4 4 3.5 CCCCCCCCc1ccc([C@H]2C[C@H](COP(=O)(O)O)N[C@@H]2CO)cc1 10.1016/j.bmcl.2011.09.049
10883396 10421 45 None -21 15 Human 8.1 pEC50 = 8.1 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2006.10.014
5283560 10421 45 None -21 15 Human 8.1 pEC50 = 8.1 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2006.10.014
911 10421 45 None -21 15 Human 8.1 pEC50 = 8.1 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2006.10.014
CHEMBL225155 10421 45 None -21 15 Human 8.1 pEC50 = 8.1 Functional
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2006.10.014
57397320 74684 0 None -1 3 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 357 3 0 4 3.8 C/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910688 74684 0 None -1 3 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 357 3 0 4 3.8 C/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
44620886 66189 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 302 6 0 5 3.4 Cc1ccc(OCCOc2ccc(C)nc2[N+](=O)[O-])c(C)c1 10.1016/j.bmcl.2011.10.096
CHEMBL1710229 66189 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 302 6 0 5 3.4 Cc1ccc(OCCOc2ccc(C)nc2[N+](=O)[O-])c(C)c1 10.1016/j.bmcl.2011.10.096
44620886 66189 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 302 6 0 5 3.4 Cc1ccc(OCCOc2ccc(C)nc2[N+](=O)[O-])c(C)c1 nan
CHEMBL1710229 66189 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 302 6 0 5 3.4 Cc1ccc(OCCOc2ccc(C)nc2[N+](=O)[O-])c(C)c1 nan
57393481 76547 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 325 6 0 3 4.7 CCc1nc(C)ccc1OCCOc1ccc(Cl)cc1Cl 10.1016/j.bmcl.2011.10.096
CHEMBL1935697 76547 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 325 6 0 3 4.7 CCc1nc(C)ccc1OCCOc1ccc(Cl)cc1Cl 10.1016/j.bmcl.2011.10.096
58344692 151700 0 None -7413 3 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 459 5 2 7 3.4 CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NC(=O)N3CC(O)C3)no2)cc1C#N nan
CHEMBL3910269 151700 0 None -7413 3 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 459 5 2 7 3.4 CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NC(=O)N3CC(O)C3)no2)cc1C#N nan
44599207 10381 43 None -257 5 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 10.1016/j.bmcl.2013.09.058
5326 10381 43 None -257 5 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 10.1016/j.bmcl.2013.09.058
9289 10381 43 None -257 5 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 10.1016/j.bmcl.2013.09.058
CHEMBL2336071 10381 43 None -257 5 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 10.1016/j.bmcl.2013.09.058
DB12371 10381 43 None -257 5 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assayAgonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
ChEMBL 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 10.1016/j.bmcl.2013.09.058
135502886 128454 24 None -1 4 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 221 1 2 4 1.1 NC(=S)c1cc2ccc(O)cc2oc1=O nan
CHEMBL358644 128454 24 None -1 4 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 221 1 2 4 1.1 NC(=S)c1cc2ccc(O)cc2oc1=O nan
733831 39016 10 None 2 3 Human 6.1 pEC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 328 4 0 7 2.8 CCOC(=O)c1cc2ccc(OC(=O)c3ccco3)cc2oc1=O nan
CHEMBL1409828 39016 10 None 2 3 Human 6.1 pEC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 328 4 0 7 2.8 CCOC(=O)c1cc2ccc(OC(=O)c3ccco3)cc2oc1=O nan
52938426 10149 12 None -34673 5 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 360 4 1 6 4.0 N#Cc1cc(ccc1OC(C)C)c1onc(n1)c1cccc2c1CC[C@@H]2N nan
9889 10149 12 None -34673 5 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 360 4 1 6 4.0 N#Cc1cc(ccc1OC(C)C)c1onc(n1)c1cccc2c1CC[C@@H]2N nan
CHEMBL3899384 10149 12 None -34673 5 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 360 4 1 6 4.0 N#Cc1cc(ccc1OC(C)C)c1onc(n1)c1cccc2c1CC[C@@H]2N nan
11222939 74349 9 None -12 4 Human 7.1 pEC50 = 7.1 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1021/jm050242f
44438254 74349 9 None -12 4 Human 7.1 pEC50 = 7.1 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1021/jm050242f
CHEMBL190006 74349 9 None -12 4 Human 7.1 pEC50 = 7.1 Functional
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 10.1021/jm050242f
46881876 12373 0 None -3 3 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 335 13 2 3 4.6 CCCCCCCOc1ccc(CC[C@](C)(N)CCC(=O)O)cc1 10.1016/j.bmcl.2010.01.118
CHEMBL1077288 12373 0 None -3 3 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
ChEMBL 335 13 2 3 4.6 CCCCCCCOc1ccc(CC[C@](C)(N)CCC(=O)O)cc1 10.1016/j.bmcl.2010.01.118
1776080 114911 7 None 1 3 Human 6.1 pEC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 343 2 0 4 3.8 C/N=C1/S/C(=C\c2cc(C)n(-c3ccccc3F)c2C)C(=O)N1C nan
CHEMBL3195883 114911 7 None 1 3 Human 6.1 pEC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 343 2 0 4 3.8 C/N=C1/S/C(=C\c2cc(C)n(-c3ccccc3F)c2C)C(=O)N1C nan
2891826 60727 12 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 362 5 0 5 4.9 COc1ccc(C2CC(c3cccs3)=NN2c2ccc(C=O)cc2)cc1 nan
CHEMBL1605463 60727 12 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 362 5 0 5 4.9 COc1ccc(C2CC(c3cccs3)=NN2c2ccc(C=O)cc2)cc1 nan
90660718 66758 0 None 1 3 Human 7.1 pEC50 = 7.1 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 391 4 0 5 3.9 C/N=C1\S/C(=C/c2cc(C)n(Cc3c(F)cccc3F)c2C)C(=O)N1OC nan
CHEMBL1734070 66758 0 None 1 3 Human 7.1 pEC50 = 7.1 Functional
PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]PUBCHEM_BIOASSAY: Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1509, AID1523, AID1563, AID1686, AID1701, AID1801, AID463118, AID463119, AID463122, AID463123, AID463129, AID463225, AID504400]
ChEMBL 391 4 0 5 3.9 C/N=C1\S/C(=C/c2cc(C)n(Cc3c(F)cccc3F)c2C)C(=O)N1OC nan
16196416 36294 1 None - 1 Human 4.0 pEC50 = 4.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 482 10 3 5 3.4 O=C(NCc1ccccc1)c1nc[nH]c1C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 nan
CHEMBL1384911 36294 1 None - 1 Human 4.0 pEC50 = 4.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 482 10 3 5 3.4 O=C(NCc1ccccc1)c1nc[nH]c1C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1 nan
58344778 161316 0 None -53703 5 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 360 4 1 6 4.0 CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4N)no2)cc1C#N nan
CHEMBL3902160 161316 0 None -53703 5 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 360 4 1 6 4.0 CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4N)no2)cc1C#N nan
CHEMBL3990889 161316 0 None -53703 5 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
ChEMBL 360 4 1 6 4.0 CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4N)no2)cc1C#N nan
57400714 74685 0 None -2 3 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 375 3 0 4 4.0 C/N=C1\S/C(=C\c2cc(C)n(Cc3c(F)cccc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
CHEMBL1910689 74685 0 None -2 3 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay
ChEMBL 375 3 0 4 4.0 C/N=C1\S/C(=C\c2cc(C)n(Cc3c(F)cccc3F)c2C)C(=O)N1C 10.1016/j.bmcl.2011.09.049
57400396 76542 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 340 6 0 4 4.6 Cc1ccc(OCCCc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
CHEMBL1935683 76542 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assayAgonist activity at human S1P4R expressed in human U2OS cells containing EDG6 gene co-expressing GAL4-VP16 and beta-arrestin/TEV protease assessed as migration of VP16-GAL4 into nucleus by FERT based beta-lactamase reporter gene assay
ChEMBL 340 6 0 4 4.6 Cc1ccc(OCCCc2ccc(Cl)cc2Cl)c([N+](=O)[O-])n1 10.1016/j.bmcl.2011.10.096
2842931 53326 14 None -3 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 328 3 0 4 5.4 Clc1ccc(N2N=C(c3cccs3)CC2c2ccco2)cc1 nan
CHEMBL1537907 53326 14 None -3 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 328 3 0 4 5.4 Clc1ccc(N2N=C(c3cccs3)CC2c2ccco2)cc1 nan
664390 38212 11 None 2 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 447 5 2 7 2.4 N=c1c(C(=O)NCc2ccc(F)cc2)cc2c(=O)n3ccccc3nc2n1CC1CCCO1 nan
CHEMBL1402796 38212 11 None 2 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 447 5 2 7 2.4 N=c1c(C(=O)NCc2ccc(F)cc2)cc2c(=O)n3ccccc3nc2n1CC1CCCO1 nan
67001 55979 23 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 321 5 1 5 2.4 CCN(c1ccccc1)S(=O)(=O)c1cc([N+](=O)[O-])ccc1N nan
CHEMBL1562579 55979 23 None - 1 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]
ChEMBL 321 5 1 5 2.4 CCN(c1ccccc1)S(=O)(=O)c1cc([N+](=O)[O-])ccc1N nan
998879 40932 10 None 18 2 Human 6.0 pIC50 = 6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 371 4 1 7 3.6 Cc1ccc(-c2nc(NC(=O)c3nn(C)cc3[N+](=O)[O-])sc2C)cc1C nan
CHEMBL1425921 40932 10 None 18 2 Human 6.0 pIC50 = 6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 371 4 1 7 3.6 Cc1ccc(-c2nc(NC(=O)c3nn(C)cc3[N+](=O)[O-])sc2C)cc1C nan
2767048 30246 12 None 6 2 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 379 4 1 6 3.3 O=C(Nc1ccccc1)c1nnsc1S(=O)(=O)c1ccc(Cl)cc1 nan
CHEMBL1333510 30246 12 None 6 2 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 379 4 1 6 3.3 O=C(Nc1ccccc1)c1nnsc1S(=O)(=O)c1ccc(Cl)cc1 nan
2330223 52367 6 None 5 4 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 391 3 1 5 2.1 Cc1ccc(NC(=O)C2=C(c3ccccc3)S(=O)(=O)CCS2(=O)=O)cc1 nan
CHEMBL1529115 52367 6 None 5 4 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 391 3 1 5 2.1 Cc1ccc(NC(=O)C2=C(c3ccccc3)S(=O)(=O)CCS2(=O)=O)cc1 nan
44607577 50667 0 None 120 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 415 5 1 2 7.8 CC(C)c1cccc(C(C)C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1511839 50667 0 None 120 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 415 5 1 2 7.8 CC(C)c1cccc(C(C)C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
44607577 50667 0 None 120 2 Human 7.0 pIC50 = 7.0 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 415 5 1 2 7.8 CC(C)c1cccc(C(C)C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
CHEMBL1511839 50667 0 None 120 2 Human 7.0 pIC50 = 7.0 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 415 5 1 2 7.8 CC(C)c1cccc(C(C)C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
998685 40798 14 None 7 3 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 357 4 1 7 3.3 Cc1ccc(-c2nc(NC(=O)c3nn(C)cc3[N+](=O)[O-])sc2C)cc1 nan
CHEMBL1424697 40798 14 None 7 3 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 357 4 1 7 3.3 Cc1ccc(-c2nc(NC(=O)c3nn(C)cc3[N+](=O)[O-])sc2C)cc1 nan
3838273 53963 15 None 1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 370 3 0 5 4.3 O=S(=O)(c1ccc(Cl)c(Cl)c1)c1snnc1-c1ccccc1 nan
CHEMBL1543295 53963 15 None 1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 370 3 0 5 4.3 O=S(=O)(c1ccc(Cl)c(Cl)c1)c1snnc1-c1ccccc1 nan
4576185 48607 13 None 7 4 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 413 7 1 9 3.3 COc1ccc(Oc2cc(NC(=O)c3nn(C)cc3[N+](=O)[O-])cc([N+](=O)[O-])c2)cc1 nan
CHEMBL1493442 48607 13 None 7 4 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 413 7 1 9 3.3 COc1ccc(Oc2cc(NC(=O)c3nn(C)cc3[N+](=O)[O-])cc([N+](=O)[O-])c2)cc1 nan
3236803 48517 11 None 3 4 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 302 2 0 4 2.6 CS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
CHEMBL1492648 48517 11 None 3 4 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 302 2 0 4 2.6 CS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
655335 39150 5 None 9 3 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 491 7 1 9 4.0 CC(C)c1nnc(NC(=O)CCS(=O)(=O)c2nc(-c3cccs3)cc(C(F)(F)F)n2)s1 nan
CHEMBL1410897 39150 5 None 9 3 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 491 7 1 9 4.0 CC(C)c1nnc(NC(=O)CCS(=O)(=O)c2nc(-c3cccs3)cc(C(F)(F)F)n2)s1 nan
2767048 30246 12 None 6 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 379 4 1 6 3.3 O=C(Nc1ccccc1)c1nnsc1S(=O)(=O)c1ccc(Cl)cc1 nan
CHEMBL1333510 30246 12 None 6 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 379 4 1 6 3.3 O=C(Nc1ccccc1)c1nnsc1S(=O)(=O)c1ccc(Cl)cc1 nan
1486982 40778 16 None 3 2 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 363 4 1 5 3.6 O=C(Nc1ccccc1)c1nnsc1[S+]([O-])c1ccc(Cl)cc1 nan
CHEMBL1424562 40778 16 None 3 2 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 363 4 1 5 3.6 O=C(Nc1ccccc1)c1nnsc1[S+]([O-])c1ccc(Cl)cc1 nan
2801235 42357 37 None 7 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 328 4 0 6 2.5 COc1ccc([N+](=O)[O-])c(S(=O)(=O)c2ccc(Cl)cc2)n1 nan
CHEMBL1439384 42357 37 None 7 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 328 4 0 6 2.5 COc1ccc([N+](=O)[O-])c(S(=O)(=O)c2ccc(Cl)cc2)n1 nan
54581611 69242 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 435 4 1 2 7.8 Cc1cc(-c2ccccc2)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779904 69242 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 435 4 1 2 7.8 Cc1cc(-c2ccccc2)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
54586463 69249 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 297 3 1 3 4.9 Cc1cccc(C)c1NC(=O)c1ccc(-c2cccs2)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779914 69249 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 297 3 1 3 4.9 Cc1cccc(C)c1NC(=O)c1ccc(-c2cccs2)o1 10.1016/j.bmcl.2011.04.097
883460 61100 5 None 13 4 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 254 4 0 3 3.7 CN(c1ccccc1)c1ccc(/C=C/[N+](=O)[O-])cc1 nan
CHEMBL1608392 61100 5 None 13 4 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 254 4 0 3 3.7 CN(c1ccccc1)c1ccc(/C=C/[N+](=O)[O-])cc1 nan
663900 31247 8 None 5 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 423 7 1 7 4.0 Cc1ccccc1CS(=O)(=O)c1nnc([C@H](CC(C)C)NC(=O)OC(C)(C)C)o1 nan
CHEMBL1341981 31247 8 None 5 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 423 7 1 7 4.0 Cc1ccccc1CS(=O)(=O)c1nnc([C@H](CC(C)C)NC(=O)OC(C)(C)C)o1 nan
1486982 40778 16 None 3 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 363 4 1 5 3.6 O=C(Nc1ccccc1)c1nnsc1[S+]([O-])c1ccc(Cl)cc1 nan
CHEMBL1424562 40778 16 None 3 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 363 4 1 5 3.6 O=C(Nc1ccccc1)c1nnsc1[S+]([O-])c1ccc(Cl)cc1 nan
2221997 34078 14 None 7 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 254 3 0 7 0.1 COc1cccc(-n2nnnc2S(C)(=O)=O)c1 nan
CHEMBL1367316 34078 14 None 7 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 254 3 0 7 0.1 COc1cccc(-n2nnnc2S(C)(=O)=O)c1 nan
1474465 31429 24 None 2 5 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 312 3 0 5 2.7 Cc1ccc(C(=O)OCn2ncc(Cl)c(Cl)c2=O)cc1 nan
CHEMBL1343392 31429 24 None 2 5 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 312 3 0 5 2.7 Cc1ccc(C(=O)OCn2ncc(Cl)c(Cl)c2=O)cc1 nan
5286934 56075 8 None 2 5 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 294 9 0 4 2.4 CCCCS(=O)(=O)/C=C\C=C/S(=O)(=O)CCCC nan
CHEMBL1563483 56075 8 None 2 5 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 294 9 0 4 2.4 CCCCS(=O)(=O)/C=C\C=C/S(=O)(=O)CCCC nan
1336753 36937 14 None 7 4 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 403 4 1 6 3.9 O=[N+]([O-])c1cc(S(=O)(=O)C(F)(F)F)ccc1Sc1nc2ccccc2[nH]1 nan
CHEMBL1390139 36937 14 None 7 4 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 403 4 1 6 3.9 O=[N+]([O-])c1cc(S(=O)(=O)C(F)(F)F)ccc1Sc1nc2ccccc2[nH]1 nan
54584551 69252 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 295 3 0 3 4.4 Cc1cccc(C)c1N(C)C(=O)c1ccc(-c2ccco2)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779917 69252 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 295 3 0 3 4.4 Cc1cccc(C)c1N(C)C(=O)c1ccc(-c2ccco2)o1 10.1016/j.bmcl.2011.04.097
900031 49336 11 None 11 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 340 3 0 3 4.5 CC(=O)n1cc(N(C(=O)CCl)c2ccc(C)cc2)c2ccccc21 nan
CHEMBL1500227 49336 11 None 11 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 340 3 0 3 4.5 CC(=O)n1cc(N(C(=O)CCl)c2ccc(C)cc2)c2ccccc21 nan
305322 30165 13 None 2 2 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 326 3 0 5 2.5 O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1CC1CCCO1 nan
CHEMBL1332881 30165 13 None 2 2 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 326 3 0 5 2.5 O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1CC1CCCO1 nan
4252324 61683 9 None 3 2 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 320 7 3 6 1.2 O=C(CCl)Nc1cc(SCC(O)CO)cc([N+](=O)[O-])c1 nan
CHEMBL1613578 61683 9 None 3 2 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 320 7 3 6 1.2 O=C(CCl)Nc1cc(SCC(O)CO)cc([N+](=O)[O-])c1 nan
2320547 53064 1 None 3 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 391 3 0 6 3.0 CN1/C(=C/C(=O)c2nc(S(C)(=O)=O)ncc2Cl)C(C)(C)c2ccccc21 nan
CHEMBL1535546 53064 1 None 3 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 391 3 0 6 3.0 CN1/C(=C/C(=O)c2nc(S(C)(=O)=O)ncc2Cl)C(C)(C)c2ccccc21 nan
4019447 26306 6 None 1 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 386 5 1 7 2.4 COc1cc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)c(C)cc1[N+](=O)[O-] nan
CHEMBL1299526 26306 6 None 1 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 386 5 1 7 2.4 COc1cc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)c(C)cc1[N+](=O)[O-] nan
2035866 34545 10 None 4 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 374 5 0 6 2.5 COC(=O)CCS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
CHEMBL1370681 34545 10 None 4 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 374 5 0 6 2.5 COC(=O)CCS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
2801236 86963 7 None 7 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 294 4 0 6 1.8 COc1ccc([N+](=O)[O-])c(S(=O)(=O)c2ccccc2)n1 nan
CHEMBL213580 86963 7 None 7 3 Human 5.9 pIC50 = 5.9 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 294 4 0 6 1.8 COc1ccc([N+](=O)[O-])c(S(=O)(=O)c2ccccc2)n1 nan
977927 54113 8 None 6 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 283 3 1 3 3.5 CCc1ccc2c(c1)/C(=C/C(=O)c1cccs1)C(=O)N2 nan
CHEMBL1544423 54113 8 None 6 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 283 3 1 3 3.5 CCc1ccc2c(c1)/C(=C/C(=O)c1cccs1)C(=O)N2 nan
2585205 60789 7 None 6 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 369 5 1 6 2.4 CCOC(=O)c1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1 nan
CHEMBL1605956 60789 7 None 6 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 369 5 1 6 2.4 CCOC(=O)c1ccc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)cc1 nan
9660957 79531 12 None 1 5 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 330 4 0 5 2.3 CCn1c(Cl)c(C=O)s/c1=N\S(=O)(=O)c1ccccc1 nan
CHEMBL1999049 79531 12 None 1 5 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 330 4 0 5 2.3 CCn1c(Cl)c(C=O)s/c1=N\S(=O)(=O)c1ccccc1 nan
2585042 53619 6 None 3 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 480 4 0 6 2.2 O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1 nan
CHEMBL1540377 53619 6 None 3 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 480 4 0 6 2.2 O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1 nan
1475337 27503 12 None -1 4 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 414 6 1 5 3.6 COc1ccc(NC(=O)/C(Cl)=C(/Cl)S(=O)(=O)Cc2ccc(C)cc2)cn1 nan
CHEMBL1309232 27503 12 None -1 4 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 414 6 1 5 3.6 COc1ccc(NC(=O)/C(Cl)=C(/Cl)S(=O)(=O)Cc2ccc(C)cc2)cn1 nan
704848 40215 14 None 2 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 333 2 0 5 3.3 Cc1ccnc(N2C(=O)c3cccc4c([N+](=O)[O-])ccc(c34)C2=O)c1 nan
CHEMBL1419909 40215 14 None 2 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 333 2 0 5 3.3 Cc1ccnc(N2C(=O)c3cccc4c([N+](=O)[O-])ccc(c34)C2=O)c1 nan
1916369 48884 8 None 9 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 352 5 1 6 2.4 COC(CNC(=O)c1ccc2c3c(onc13)-c1ccccc1C2=O)OC nan
CHEMBL1496231 48884 8 None 9 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 352 5 1 6 2.4 COC(CNC(=O)c1ccc2c3c(onc13)-c1ccccc1C2=O)OC nan
44607575 59321 0 None 29 5 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 4 1 3 5.8 COc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1592119 59321 0 None 29 5 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 4 1 3 5.8 COc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
44607575 59321 0 None 29 5 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 375 4 1 3 5.8 COc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
CHEMBL1592119 59321 0 None 29 5 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 375 4 1 3 5.8 COc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
2430298 30708 7 None 2 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 323 2 0 4 2.1 O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCc2ccccc21 nan
CHEMBL1337227 30708 7 None 2 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 323 2 0 4 2.1 O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCc2ccccc21 nan
2980954 36021 8 None 3 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 420 5 1 6 3.4 O=C(Nc1ccc(N2CCN(C(=O)c3ccccc3)CC2)cc1)c1ccc([N+](=O)[O-])o1 nan
CHEMBL1382558 36021 8 None 3 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 420 5 1 6 3.4 O=C(Nc1ccc(N2CCN(C(=O)c3ccccc3)CC2)cc1)c1ccc([N+](=O)[O-])o1 nan
5680788 79568 2 None 2 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 410 4 2 6 3.8 O=C1C(Nc2ccc(O)cc2)=C/C(=N/S(=O)(=O)c2cccs2)c2ccccc21 nan
CHEMBL2000517 79568 2 None 2 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 410 4 2 6 3.8 O=C1C(Nc2ccc(O)cc2)=C/C(=N/S(=O)(=O)c2cccs2)c2ccccc21 nan
1114196 46343 6 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 359 3 1 2 6.1 Cc1ccc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1473443 46343 6 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 359 3 1 2 6.1 Cc1ccc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c1 10.1016/j.bmcl.2011.04.097
1114196 46343 6 None - 1 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 359 3 1 2 6.1 Cc1ccc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c1 nan
CHEMBL1473443 46343 6 None - 1 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 359 3 1 2 6.1 Cc1ccc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c1 nan
1474489 47529 15 None 1 6 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 404 3 0 5 2.7 O=C(OCn1ncc(Br)c(Br)c1=O)c1ccc(F)cc1 nan
CHEMBL1485010 47529 15 None 1 6 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 404 3 0 5 2.7 O=C(OCn1ncc(Br)c(Br)c1=O)c1ccc(F)cc1 nan
6217704 39357 3 None -7 6 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 490 7 0 8 5.2 CCOC(=O)/C(=C\c1ccc(OC(F)F)cc1)C1=Nn2c(nnc2-c2ccc(Cl)cc2)SC1 nan
CHEMBL1412583 39357 3 None -7 6 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 490 7 0 8 5.2 CCOC(=O)/C(=C\c1ccc(OC(F)F)cc1)C1=Nn2c(nnc2-c2ccc(Cl)cc2)SC1 nan
44607579 50666 1 None 56 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 379 3 1 2 6.5 Cc1cccc(Cl)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1511831 50666 1 None 56 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 379 3 1 2 6.5 Cc1cccc(Cl)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
44607579 50666 1 None 56 2 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 379 3 1 2 6.5 Cc1cccc(Cl)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
CHEMBL1511831 50666 1 None 56 2 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 379 3 1 2 6.5 Cc1cccc(Cl)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
9551645 43544 5 None 4 2 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 457 7 1 7 4.2 Cc1ccccc1CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 nan
CHEMBL1449794 43544 5 None 4 2 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 457 7 1 7 4.2 Cc1ccccc1CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 nan
135415440 205829 11 None 4 5 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 295 3 2 6 3.0 Cc1ccc(Nc2cc(C)nn2-c2nc(C)cc(O)n2)cc1 nan
CHEMBL586135 205829 11 None 4 5 Human 6.8 pIC50 = 6.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 295 3 2 6 3.0 Cc1ccc(Nc2cc(C)nn2-c2nc(C)cc(O)n2)cc1 nan
5290862 54493 10 None 14 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 352 7 1 2 4.4 O=C(/C=C/c1ccccc1)CC(O)(c1ccccc1)C(F)(F)C(F)F nan
CHEMBL1547643 54493 10 None 14 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 352 7 1 2 4.4 O=C(/C=C/c1ccccc1)CC(O)(c1ccccc1)C(F)(F)C(F)F nan
100520 39499 6 None 4 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 240 3 0 7 2.0 O=[N+]([O-])c1cnc(Sc2ccncn2)s1 nan
CHEMBL1413680 39499 6 None 4 4 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 240 3 0 7 2.0 O=[N+]([O-])c1cnc(Sc2ccncn2)s1 nan
56682428 71932 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 333 3 1 2 5.7 Cc1ccc(C)c(-c2cc(C)c(C(=O)Nc3c(C)cccc3C)o2)c1 10.1016/j.bmcl.2011.06.132
CHEMBL1824257 71932 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 333 3 1 2 5.7 Cc1ccc(C)c(-c2cc(C)c(C(=O)Nc3c(C)cccc3C)o2)c1 10.1016/j.bmcl.2011.06.132
1474487 26838 16 None 1 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 420 3 0 5 3.2 O=C(OCn1ncc(Br)c(Br)c1=O)c1ccccc1Cl nan
CHEMBL1303810 26838 16 None 1 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 420 3 0 5 3.2 O=C(OCn1ncc(Br)c(Br)c1=O)c1ccccc1Cl nan
9631442 78946 6 None 3 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 303 3 2 4 3.8 Cc1c(/C=N/Nc2nc3ccccc3[nH]2)c2ccccc2n1C nan
CHEMBL1979747 78946 6 None 3 3 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 303 3 2 4 3.8 Cc1c(/C=N/Nc2nc3ccccc3[nH]2)c2ccccc2n1C nan
2295300 43192 10 None 3 5 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 356 8 1 5 3.7 CCOc1cc(/C=C\[N+](=O)[O-])ccc1OCC(=O)Nc1ccccc1C nan
CHEMBL1446971 43192 10 None 3 5 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 356 8 1 5 3.7 CCOc1cc(/C=C\[N+](=O)[O-])ccc1OCC(=O)Nc1ccccc1C nan
1007755 32796 12 None - 1 Human 6.7 pIC50 = 6.7 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 359 3 1 2 6.1 Cc1ccc(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 nan
CHEMBL1354895 32796 12 None - 1 Human 6.7 pIC50 = 6.7 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 359 3 1 2 6.1 Cc1ccc(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 nan
5311103 53267 14 None 3 4 Human 6.7 pIC50 = 6.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 466 2 2 6 4.4 CN[C@H]1C[C@H]2O[C@@](C)([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 nan
CHEMBL1537489 53267 14 None 3 4 Human 6.7 pIC50 = 6.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 466 2 2 6 4.4 CN[C@H]1C[C@H]2O[C@@](C)([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 nan
72813 209069 97 None 4 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 240 1 0 3 2.5 O=c1c(Cl)c(Cl)cnn1-c1ccccc1 nan
CHEMBL610198 209069 97 None 4 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 240 1 0 3 2.5 O=c1c(Cl)c(Cl)cnn1-c1ccccc1 nan
3143422 52377 6 None 6 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 355 5 2 6 3.6 Cc1cc(NC(=O)c2ccc([N+](=O)[O-])o2)ccc1NC(=O)c1ccco1 nan
CHEMBL1529188 52377 6 None 6 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 355 5 2 6 3.6 Cc1cc(NC(=O)c2ccc([N+](=O)[O-])o2)ccc1NC(=O)c1ccco1 nan
2766929 57084 26 None 2 4 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 287 1 0 4 3.1 CC(C)(C)c1ccc(-n2nc(C#N)c(Cl)cc2=O)cc1 nan
CHEMBL1572001 57084 26 None 2 4 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 287 1 0 4 3.1 CC(C)(C)c1ccc(-n2nc(C#N)c(Cl)cc2=O)cc1 nan
1484340 52840 22 None 1 4 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 298 3 1 3 3.1 O=C1C=C(c2ccc(Cl)cc2)C(=O)N1Nc1ccccc1 nan
CHEMBL1533279 52840 22 None 1 4 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 298 3 1 3 3.1 O=C1C=C(c2ccc(Cl)cc2)C(=O)N1Nc1ccccc1 nan
5290861 61381 15 None 6 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 320 5 1 2 4.1 O=C(/C=C/c1ccccc1)CC(O)(c1ccccc1)C(F)(F)F nan
CHEMBL1610831 61381 15 None 6 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 320 5 1 2 4.1 O=C(/C=C/c1ccccc1)CC(O)(c1ccccc1)C(F)(F)F nan
6258408 43229 11 None 3 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 328 3 1 4 3.4 CC1=NNC(=O)/C1=C\c1cn(-c2ccccc2)nc1-c1ccccc1 nan
CHEMBL1447306 43229 11 None 3 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 328 3 1 4 3.4 CC1=NNC(=O)/C1=C\c1cn(-c2ccccc2)nc1-c1ccccc1 nan
11452022 10368 39 None -26 6 Human 8.7 pIC50 = 8.7 Functional
Agonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2011.10.088
6996 10368 39 None -26 6 Human 8.7 pIC50 = 8.7 Functional
Agonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2011.10.088
CHEMBL366208 10368 39 None -26 6 Human 8.7 pIC50 = 8.7 Functional
Agonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assayAgonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2011.10.088
1363299 39717 10 None 37 5 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccc(Cl)cc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1415555 39717 10 None 37 5 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccc(Cl)cc2Cl)o1 10.1016/j.bmcl.2011.04.097
5761997 41051 5 None 4 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 369 5 0 6 4.2 COc1ccc(C(=O)/C(=C\c2ccco2)N2C=CC=CC2=C(C#N)C#N)cc1 nan
CHEMBL1426792 41051 5 None 4 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 369 5 0 6 4.2 COc1ccc(C(=O)/C(=C\c2ccco2)N2C=CC=CC2=C(C#N)C#N)cc1 nan
375895 27637 8 None 3 4 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 286 2 0 4 2.8 COc1ccc(OC)c2c1C(=O)C(Cl)=C(Cl)C2=O nan
CHEMBL131037 27637 8 None 3 4 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 286 2 0 4 2.8 COc1ccc(OC)c2c1C(=O)C(Cl)=C(Cl)C2=O nan
6763 198226 104 None 1 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 208 0 0 2 2.7 O=C1C(=O)c2ccccc2-c2ccccc21 nan
CHEMBL51931 198226 104 None 1 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 208 0 0 2 2.7 O=C1C(=O)c2ccccc2-c2ccccc21 nan
282594 52121 17 None 2 5 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 331 2 0 3 3.7 CC(=O)N(C1=C(Cl)C(=O)c2ccccc2C1=O)C1CCCCC1 nan
CHEMBL1526855 52121 17 None 2 5 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 331 2 0 3 3.7 CC(=O)N(C1=C(Cl)C(=O)c2ccccc2C1=O)C1CCCCC1 nan
991251 46946 16 None 4 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 361 3 1 5 2.9 CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc3ccccc3c2)n1 nan
CHEMBL1480031 46946 16 None 4 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 361 3 1 5 2.9 CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc3ccccc3c2)n1 nan
2769258 50166 22 None 10 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 270 2 0 4 2.5 COc1ccc(-n2ncc(Cl)c(Cl)c2=O)cc1 nan
CHEMBL1507537 50166 22 None 10 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 270 2 0 4 2.5 COc1ccc(-n2ncc(Cl)c(Cl)c2=O)cc1 nan
51000470 69228 0 None 144 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 389 4 2 3 5.6 Cc1cc(CO)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779890 69228 0 None 144 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 389 4 2 3 5.6 Cc1cc(CO)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
56662043 71931 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 319 3 1 2 5.4 Cc1ccc(C)c(-c2coc(C(=O)Nc3c(C)cccc3C)c2)c1 10.1016/j.bmcl.2011.06.132
CHEMBL1824256 71931 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 319 3 1 2 5.4 Cc1ccc(C)c(-c2coc(C(=O)Nc3c(C)cccc3C)c2)c1 10.1016/j.bmcl.2011.06.132
2585250 35130 6 None 5 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 396 6 1 5 2.2 CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O nan
CHEMBL1374788 35130 6 None 5 3 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 396 6 1 5 2.2 CCc1ccccc1NC(=O)CN(C)C(=O)Cn1ncc(Cl)c(Cl)c1=O nan
900971 45849 31 None 3 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 316 3 0 4 3.1 O=C(Cn1ncc(Cl)c(Cl)c1=O)c1ccc(Cl)cc1 nan
CHEMBL1468847 45849 31 None 3 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 316 3 0 4 3.1 O=C(Cn1ncc(Cl)c(Cl)c1=O)c1ccc(Cl)cc1 nan
78545 33808 24 None 15 3 Human 6.7 pIC50 = 6.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 204 1 0 3 1.7 Cc1cc([N+](=O)[O-])c2ccccc2[n+]1[O-] nan
CHEMBL1364999 33808 24 None 15 3 Human 6.7 pIC50 = 6.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 204 1 0 3 1.7 Cc1cc([N+](=O)[O-])c2ccccc2[n+]1[O-] nan
5187118 58636 6 None 2 4 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 338 3 1 3 4.8 Oc1c(C(c2ccccc2Cl)N2CCCC2)ccc2cccnc12 nan
CHEMBL1585527 58636 6 None 2 4 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 338 3 1 3 4.8 Oc1c(C(c2ccccc2Cl)N2CCCC2)ccc2cccnc12 nan
1363299 39717 10 None 37 5 Human 6.7 pIC50 = 6.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccc(Cl)cc2Cl)o1 nan
CHEMBL1415555 39717 10 None 37 5 Human 6.7 pIC50 = 6.7 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccc(Cl)cc2Cl)o1 nan
56675824 71930 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 319 3 1 2 5.4 Cc1ccc(C)c(-c2cc(C(=O)Nc3c(C)cccc3C)co2)c1 10.1016/j.bmcl.2011.06.132
CHEMBL1824255 71930 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 319 3 1 2 5.4 Cc1ccc(C)c(-c2cc(C(=O)Nc3c(C)cccc3C)co2)c1 10.1016/j.bmcl.2011.06.132
2402478 56489 6 None 4 2 Human 5.6 pIC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 429 8 0 7 3.0 CN(CCC#N)C(=O)COC(=O)c1ccccc1C(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
CHEMBL1566808 56489 6 None 4 2 Human 5.6 pIC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 429 8 0 7 3.0 CN(CCC#N)C(=O)COC(=O)c1ccccc1C(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
56672438 71935 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 343 3 1 1 6.1 Cc1ccc(C)c(-c2cc(C(=O)Nc3c(C)cccc3C)ccc2C)c1 10.1016/j.bmcl.2011.06.132
CHEMBL1824260 71935 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 343 3 1 1 6.1 Cc1ccc(C)c(-c2cc(C(=O)Nc3c(C)cccc3C)ccc2C)c1 10.1016/j.bmcl.2011.06.132
3270222 43622 6 None - 1 Human 5.6 pIC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 312 4 0 6 1.6 CCCC(=O)N(C1CC(C)C(C#N)(C#N)C1(C#N)C#N)N(C)C nan
CHEMBL1450393 43622 6 None - 1 Human 5.6 pIC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 312 4 0 6 1.6 CCCC(=O)N(C1CC(C)C(C#N)(C#N)C1(C#N)C#N)N(C)C nan
10312 8077 27 None 154 4 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 388 4 2 3 5.6 NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl 10.1016/j.bmcl.2011.04.097
53358422 8077 27 None 154 4 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 388 4 2 3 5.6 NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl 10.1016/j.bmcl.2011.04.097
CHEMBL1779732 8077 27 None 154 4 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 388 4 2 3 5.6 NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl 10.1016/j.bmcl.2011.04.097
44607574 46275 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 395 3 1 2 7.0 Cc1ccc2ccccc2c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1472539 46275 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 395 3 1 2 7.0 Cc1ccc2ccccc2c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
37839 197528 25 None 19 3 Human 6.6 pIC50 = 6.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 232 2 0 2 2.8 CC1(C)C[C@H]2[C@H](C=C(C=O)[C@]3(C=O)C[C@]23C)C1 nan
CHEMBL518292 197528 25 None 19 3 Human 6.6 pIC50 = 6.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 232 2 0 2 2.8 CC1(C)C[C@H]2[C@H](C=C(C=O)[C@]3(C=O)C[C@]23C)C1 nan
44607574 46275 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 395 3 1 2 7.0 Cc1ccc2ccccc2c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
CHEMBL1472539 46275 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 395 3 1 2 7.0 Cc1ccc2ccccc2c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
2328694 60502 3 None 8 5 Human 6.6 pIC50 = 6.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 408 6 2 3 5.2 O=C(Nc1ccccc1)Nc1cc(OCC(F)(F)F)cc(OCC(F)(F)F)c1 nan
CHEMBL1603615 60502 3 None 8 5 Human 6.6 pIC50 = 6.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 408 6 2 3 5.2 O=C(Nc1ccccc1)Nc1cc(OCC(F)(F)F)cc(OCC(F)(F)F)c1 nan
665480 33900 4 None 4 2 Human 5.6 pIC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 423 7 1 7 4.0 CCC(C)[C@@H](NC(=O)OC(C)(C)C)c1nnc(S(=O)(=O)Cc2cccc(C)c2)o1 nan
CHEMBL1365696 33900 4 None 4 2 Human 5.6 pIC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 423 7 1 7 4.0 CCC(C)[C@@H](NC(=O)OC(C)(C)C)c1nnc(S(=O)(=O)Cc2cccc(C)c2)o1 nan
2743870 40671 5 None 4 3 Human 5.6 pIC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 285 5 1 9 1.7 C=CCn1c(O)nnc1Sc1ncc([N+](=O)[O-])s1 nan
CHEMBL1423626 40671 5 None 4 3 Human 5.6 pIC50 = 5.6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 285 5 1 9 1.7 C=CCn1c(O)nnc1Sc1ncc([N+](=O)[O-])s1 nan
54584549 69244 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 339 3 0 2 5.5 Cc1cccc(C)c1N(C)C(=O)c1ccc(-c2ccccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779906 69244 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 339 3 0 2 5.5 Cc1cccc(C)c1N(C)C(=O)c1ccc(-c2ccccc2Cl)o1 10.1016/j.bmcl.2011.04.097
7275219 55061 8 None - 1 Human 6.6 pIC50 = 6.6 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 339 4 1 2 5.7 CCc1cccc(C)c1NC(=O)c1ccc(-c2ccccc2Cl)o1 nan
CHEMBL1553396 55061 8 None - 1 Human 6.6 pIC50 = 6.6 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 339 4 1 2 5.7 CCc1cccc(C)c1NC(=O)c1ccc(-c2ccccc2Cl)o1 nan
44607581 37387 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 311 3 1 3 5.2 Cc1cscc1-c1ccc(C(=O)Nc2c(C)cccc2C)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1393993 37387 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 311 3 1 3 5.2 Cc1cscc1-c1ccc(C(=O)Nc2c(C)cccc2C)o1 10.1016/j.bmcl.2011.04.097
44607581 37387 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 311 3 1 3 5.2 Cc1cscc1-c1ccc(C(=O)Nc2c(C)cccc2C)o1 nan
CHEMBL1393993 37387 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 311 3 1 3 5.2 Cc1cscc1-c1ccc(C(=O)Nc2c(C)cccc2C)o1 nan
663900 31247 8 None 5 3 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 423 7 1 7 4.0 Cc1ccccc1CS(=O)(=O)c1nnc([C@H](CC(C)C)NC(=O)OC(C)(C)C)o1 nan
CHEMBL1341981 31247 8 None 5 3 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 423 7 1 7 4.0 Cc1ccccc1CS(=O)(=O)c1nnc([C@H](CC(C)C)NC(=O)OC(C)(C)C)o1 nan
2452801 31090 6 None 3 3 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 310 3 0 4 3.1 Cc1ccc(C)c(C(=O)Cn2ncc(Cl)c(Cl)c2=O)c1 nan
CHEMBL1340619 31090 6 None 3 3 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 310 3 0 4 3.1 Cc1ccc(C)c(C(=O)Cn2ncc(Cl)c(Cl)c2=O)c1 nan
44607582 42041 0 None 45 3 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 437 4 1 4 5.5 Cc1ccc(S(C)(=O)=O)c(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1436066 42041 0 None 45 3 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 437 4 1 4 5.5 Cc1ccc(S(C)(=O)=O)c(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
44607582 42041 0 None 45 3 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 437 4 1 4 5.5 Cc1ccc(S(C)(=O)=O)c(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
CHEMBL1436066 42041 0 None 45 3 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 437 4 1 4 5.5 Cc1ccc(S(C)(=O)=O)c(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
44607573 50871 0 None 54 2 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 327 3 1 2 5.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(F)ccc2F)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1514981 50871 0 None 54 2 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 327 3 1 2 5.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(F)ccc2F)o1 10.1016/j.bmcl.2011.04.097
44607573 50871 0 None 54 2 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 327 3 1 2 5.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(F)ccc2F)o1 nan
CHEMBL1514981 50871 0 None 54 2 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 327 3 1 2 5.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(F)ccc2F)o1 nan
3609942 53656 1 None 4 4 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 415 2 0 5 4.6 COC(=O)C1CN(C#N)N(c2ccc(Cl)cc2)C12c1ccccc1-c1ccccc12 nan
CHEMBL1540682 53656 1 None 4 4 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 415 2 0 5 4.6 COC(=O)C1CN(C#N)N(c2ccc(Cl)cc2)C12c1ccccc1-c1ccccc12 nan
4879810 47692 8 None 4 2 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 352 2 1 5 1.5 O=C1CN(C(=O)Cn2ncc(Cl)c(Cl)c2=O)c2ccccc2N1 nan
CHEMBL1486546 47692 8 None 4 2 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 352 2 1 5 1.5 O=C1CN(C(=O)Cn2ncc(Cl)c(Cl)c2=O)c2ccccc2N1 nan
706322 29930 9 None - 1 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 295 4 2 2 4.5 Cc1cc(NC(=O)/C=C/c2ccccc2)c(C(C)C)cc1O nan
CHEMBL1331049 29930 9 None - 1 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 295 4 2 2 4.5 Cc1cc(NC(=O)/C=C/c2ccccc2)c(C(C)C)cc1O nan
54585466 69173 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 431 5 1 4 6.2 CC(=O)OCc1cc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1779733 69173 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 431 5 1 4 6.2 CC(=O)OCc1cc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
53358423 69254 4 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 341 4 2 4 4.7 Cc1ccsc1-c1ccc(C(=O)Nc2c(C)cc(CO)cc2C)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779919 69254 4 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 341 4 2 4 4.7 Cc1ccsc1-c1ccc(C(=O)Nc2c(C)cc(CO)cc2C)o1 10.1016/j.bmcl.2011.04.097
6552076 26502 1 None 9 3 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 487 4 0 7 4.5 COC(=O)C[C@]1(C(=O)OC)CN(C#N)N(c2ccc(Cl)cc2)C12c1ccccc1-c1ccccc12 nan
CHEMBL1301125 26502 1 None 9 3 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 487 4 0 7 4.5 COC(=O)C[C@]1(C(=O)OC)CN(C#N)N(c2ccc(Cl)cc2)C12c1ccccc1-c1ccccc12 nan
6217704 39357 3 None -7 6 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 490 7 0 8 5.2 CCOC(=O)/C(=C\c1ccc(OC(F)F)cc1)C1=Nn2c(nnc2-c2ccc(Cl)cc2)SC1 nan
CHEMBL1412583 39357 3 None -7 6 Human 6.5 pIC50 = 6.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 490 7 0 8 5.2 CCOC(=O)/C(=C\c1ccc(OC(F)F)cc1)C1=Nn2c(nnc2-c2ccc(Cl)cc2)SC1 nan
2035866 34545 10 None 4 3 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 374 5 0 6 2.5 COC(=O)CCS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
CHEMBL1370681 34545 10 None 4 3 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 374 5 0 6 2.5 COC(=O)CCS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
54584548 69241 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 416 5 1 3 6.2 Cc1cc(CN(C)C)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779903 69241 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 416 5 1 3 6.2 Cc1cc(CN(C)C)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
9551645 43544 5 None 4 2 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 457 7 1 7 4.2 Cc1ccccc1CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 nan
CHEMBL1449794 43544 5 None 4 2 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 457 7 1 7 4.2 Cc1ccccc1CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 nan
2418645 55477 6 None 2 2 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 380 4 0 5 1.9 O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCN(Cc2ccccc2)CC1 nan
CHEMBL1558021 55477 6 None 2 2 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 380 4 0 5 1.9 O=C(Cn1ncc(Cl)c(Cl)c1=O)N1CCN(Cc2ccccc2)CC1 nan
2219262 41420 11 None 4 3 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 388 6 0 6 2.9 CCOC(=O)CCS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
CHEMBL1429929 41420 11 None 4 3 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 388 6 0 6 2.9 CCOC(=O)CCS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
3247230 56829 3 None 1 4 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 405 4 0 4 3.1 C=C1C(=O)C=C2CN(C(=O)c3ccccc3)[C@@](Cc3ccc(F)cc3)(C(=O)OC)[C@@H]12 nan
CHEMBL1569585 56829 3 None 1 4 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 405 4 0 4 3.1 C=C1C(=O)C=C2CN(C(=O)c3ccccc3)[C@@](Cc3ccc(F)cc3)(C(=O)OC)[C@@H]12 nan
6526694 34378 3 None 7 5 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 364 4 1 3 5.7 O=C(/C(=C/c1ccc(Cl)cc1)c1nc2ccccc2[nH]1)c1cccs1 nan
CHEMBL1369594 34378 3 None 7 5 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 364 4 1 3 5.7 O=C(/C(=C/c1ccc(Cl)cc1)c1nc2ccccc2[nH]1)c1cccs1 nan
2330223 52367 6 None 5 4 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 391 3 1 5 2.1 Cc1ccc(NC(=O)C2=C(c3ccccc3)S(=O)(=O)CCS2(=O)=O)cc1 nan
CHEMBL1529115 52367 6 None 5 4 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 391 3 1 5 2.1 Cc1ccc(NC(=O)C2=C(c3ccccc3)S(=O)(=O)CCS2(=O)=O)cc1 nan
1363299 39717 10 None 37 5 Human 7.4 pIC50 = 7.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccc(Cl)cc2Cl)o1 nan
CHEMBL1415555 39717 10 None 37 5 Human 7.4 pIC50 = 7.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccc(Cl)cc2Cl)o1 nan
2801235 42357 37 None 7 3 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 328 4 0 6 2.5 COc1ccc([N+](=O)[O-])c(S(=O)(=O)c2ccc(Cl)cc2)n1 nan
CHEMBL1439384 42357 37 None 7 3 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 328 4 0 6 2.5 COc1ccc([N+](=O)[O-])c(S(=O)(=O)c2ccc(Cl)cc2)n1 nan
779010 59372 13 None - 1 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 345 3 1 2 5.8 Cc1ccccc1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
CHEMBL1592813 59372 13 None - 1 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 345 3 1 2 5.8 Cc1ccccc1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
460749 30321 8 None 1 6 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 303 1 0 7 0.7 Cn1nc(-c2ccc(Cl)cc2)nc2c(=O)n(C)c(=O)nc1-2 nan
CHEMBL1334062 30321 8 None 1 6 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 303 1 0 7 0.7 Cn1nc(-c2ccc(Cl)cc2)nc2c(=O)n(C)c(=O)nc1-2 nan
1472225 31516 11 None 2 7 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 398 6 1 4 3.9 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 nan
CHEMBL1344225 31516 11 None 2 7 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 398 6 1 4 3.9 COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 nan
4469648 69239 2 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 373 4 1 2 6.4 CCc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779901 69239 2 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 373 4 1 2 6.4 CCc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
44607578 59121 0 None 45 2 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 379 7 1 4 5.5 CCOc1ccc(OC)cc1-c1ccc(C(=O)Nc2c(C)cccc2CC)o1 nan
CHEMBL1589684 59121 0 None 45 2 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 379 7 1 4 5.5 CCOc1ccc(OC)cc1-c1ccc(C(=O)Nc2c(C)cccc2CC)o1 nan
44607576 54882 0 None 25 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 391 5 1 4 5.5 COc1cccc(OC)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1550998 54882 0 None 25 3 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 391 5 1 4 5.5 COc1cccc(OC)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
44607576 54882 0 None 25 3 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 391 5 1 4 5.5 COc1cccc(OC)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
CHEMBL1550998 54882 0 None 25 3 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 391 5 1 4 5.5 COc1cccc(OC)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
367432 33522 12 None 15 3 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 326 5 0 4 3.0 CCOC(=O)C(=Cc1ccc(Br)cc1)C(=O)OCC nan
CHEMBL1362503 33522 12 None 15 3 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 326 5 0 4 3.0 CCOC(=O)C(=Cc1ccc(Br)cc1)C(=O)OCC nan
3006170 66322 7 None 2 3 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 325 3 5 9 -1.7 NC(=S)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(N)c12 nan
CHEMBL171699 66322 7 None 2 3 Human 6.4 pIC50 = 6.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 325 3 5 9 -1.7 NC(=S)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(N)c12 nan
1479791 42277 24 None 3 2 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 308 2 0 4 1.4 CC(=O)Cn1ncc(Br)c(Br)c1=O nan
CHEMBL1438636 42277 24 None 3 2 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 308 2 0 4 1.4 CC(=O)Cn1ncc(Br)c(Br)c1=O nan
54587490 69243 0 None 54 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 419 6 2 4 5.5 Cc1cc(OCCO)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779905 69243 0 None 54 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 419 6 2 4 5.5 Cc1cc(OCCO)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
54580604 69248 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 297 3 1 3 4.9 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccsc2)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779913 69248 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 297 3 1 3 4.9 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccsc2)o1 10.1016/j.bmcl.2011.04.097
2215161 47732 5 None 4 3 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 282 5 0 7 0.9 CCCS(=O)(=O)c1nnnn1-c1cccc(OC)c1 nan
CHEMBL1486934 47732 5 None 4 3 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 282 5 0 7 0.9 CCCS(=O)(=O)c1nnnn1-c1cccc(OC)c1 nan
238775 49581 2 None 2 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 288 4 0 3 3.0 O=C(C=C=Nc1ccccc1)C(=O)N=C=Cc1ccccc1 nan
CHEMBL1502358 49581 2 None 2 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 288 4 0 3 3.0 O=C(C=C=Nc1ccccc1)C(=O)N=C=Cc1ccccc1 nan
54580605 69253 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 327 3 2 4 4.9 Cc1ccsc1-c1ccc(C(=O)Nc2c(C)cc(O)cc2C)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779918 69253 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 327 3 2 4 4.9 Cc1ccsc1-c1ccc(C(=O)Nc2c(C)cc(O)cc2C)o1 10.1016/j.bmcl.2011.04.097
3247230 56829 3 None 1 4 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 405 4 0 4 3.1 C=C1C(=O)C=C2CN(C(=O)c3ccccc3)[C@@](Cc3ccc(F)cc3)(C(=O)OC)[C@@H]12 nan
CHEMBL1569585 56829 3 None 1 4 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 405 4 0 4 3.1 C=C1C(=O)C=C2CN(C(=O)c3ccccc3)[C@@](Cc3ccc(F)cc3)(C(=O)OC)[C@@H]12 nan
701067 34575 11 None 20 3 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 331 2 0 5 4.2 O=S1(=O)C=C(Sc2nc3ccccc3s2)c2ccccc21 nan
CHEMBL1370884 34575 11 None 20 3 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 331 2 0 5 4.2 O=S1(=O)C=C(Sc2nc3ccccc3s2)c2ccccc21 nan
878124 32716 8 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 325 3 1 2 5.5 Cc1cccc(C)c1NC(=O)c1ccc(-c2cccc(Cl)c2)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1354080 32716 8 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 325 3 1 2 5.5 Cc1cccc(C)c1NC(=O)c1ccc(-c2cccc(Cl)c2)o1 10.1016/j.bmcl.2011.04.097
878124 32716 8 None - 1 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 325 3 1 2 5.5 Cc1cccc(C)c1NC(=O)c1ccc(-c2cccc(Cl)c2)o1 nan
CHEMBL1354080 32716 8 None - 1 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 325 3 1 2 5.5 Cc1cccc(C)c1NC(=O)c1ccc(-c2cccc(Cl)c2)o1 nan
54585494 69246 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 365 5 0 4 4.9 COc1ccc(OC)c(-c2ccc(C(=O)N(C)c3c(C)cccc3C)o2)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1779910 69246 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 365 5 0 4 4.9 COc1ccc(OC)c(-c2ccc(C(=O)N(C)c3c(C)cccc3C)o2)c1 10.1016/j.bmcl.2011.04.097
44607572 37380 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 365 6 1 4 5.1 CCc1cccc(C)c1NC(=O)c1ccc(-c2cc(OC)ccc2OC)o1 nan
CHEMBL1393906 37380 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 365 6 1 4 5.1 CCc1cccc(C)c1NC(=O)c1ccc(-c2cc(OC)ccc2OC)o1 nan
54585495 69250 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 331 3 1 3 5.5 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccc(Cl)s2)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779915 69250 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 331 3 1 3 5.5 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccc(Cl)s2)o1 10.1016/j.bmcl.2011.04.097
54582605 69229 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 432 6 2 4 5.0 Cc1cc(OCC(N)=O)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779891 69229 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 432 6 2 4 5.0 Cc1cc(OCC(N)=O)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
3838273 53963 15 None 1 3 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 370 3 0 5 4.3 O=S(=O)(c1ccc(Cl)c(Cl)c1)c1snnc1-c1ccccc1 nan
CHEMBL1543295 53963 15 None 1 3 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 370 3 0 5 4.3 O=S(=O)(c1ccc(Cl)c(Cl)c1)c1snnc1-c1ccccc1 nan
1472218 34386 13 None -1 4 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 400 6 1 5 3.3 COc1ccc(NC(=O)/C(Cl)=C(/Cl)S(=O)(=O)Cc2ccccc2)cn1 nan
CHEMBL1369655 34386 13 None -1 4 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 400 6 1 5 3.3 COc1ccc(NC(=O)/C(Cl)=C(/Cl)S(=O)(=O)Cc2ccccc2)cn1 nan
1473969 42467 12 None 14 3 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 373 4 1 2 4.7 O=C(Nc1ccccc1Cl)/C(Cl)=C(\Cl)[S+]([O-])c1ccccc1 nan
CHEMBL1440300 42467 12 None 14 3 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 373 4 1 2 4.7 O=C(Nc1ccccc1Cl)/C(Cl)=C(\Cl)[S+]([O-])c1ccccc1 nan
82533 47818 70 None 2 5 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 298 3 1 3 3.3 Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)cc1 nan
CHEMBL1487635 47818 70 None 2 5 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 298 3 1 3 3.3 Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)cc1 nan
1475337 27503 12 None -1 4 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 414 6 1 5 3.6 COc1ccc(NC(=O)/C(Cl)=C(/Cl)S(=O)(=O)Cc2ccc(C)cc2)cn1 nan
CHEMBL1309232 27503 12 None -1 4 Human 6.3 pIC50 = 6.3 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 414 6 1 5 3.6 COc1ccc(NC(=O)/C(Cl)=C(/Cl)S(=O)(=O)Cc2ccc(C)cc2)cn1 nan
54585493 69238 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 4 2 3 5.3 Cc1cccc(CO)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779900 69238 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 4 2 3 5.3 Cc1cccc(CO)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
54582609 69245 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 291 3 1 2 4.8 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccccc2)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779907 69245 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 291 3 1 2 4.8 Cc1cccc(C)c1NC(=O)c1ccc(-c2ccccc2)o1 10.1016/j.bmcl.2011.04.097
54582607 69233 0 None 48 5 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 3 2 3 5.8 Cc1cc(O)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779895 69233 0 None 48 5 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 3 2 3 5.8 Cc1cc(O)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
2142309 205438 14 None 3 3 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 346 3 1 5 2.7 Cc1oc2c(c1C(=O)NCc1cccnc1)C(=O)c1ccccc1C2=O nan
CHEMBL579318 205438 14 None 3 3 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 346 3 1 5 2.7 Cc1oc2c(c1C(=O)NCc1cccnc1)C(=O)c1ccccc1C2=O nan
54581610 69234 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 4 1 3 5.8 COc1ccc(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1779896 69234 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 4 1 3 5.8 COc1ccc(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
53388307 71929 0 None 18 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 335 3 1 2 5.9 Cc1ccc(C)c(-c2ccc(C(=O)Nc3c(C)cccc3C)s2)c1 10.1016/j.bmcl.2011.06.132
CHEMBL1824254 71929 0 None 18 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 335 3 1 2 5.9 Cc1ccc(C)c(-c2ccc(C(=O)Nc3c(C)cccc3C)s2)c1 10.1016/j.bmcl.2011.06.132
2082098 47538 7 None 1 3 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 304 3 1 4 3.4 Cc1ccc(S(=O)(=O)Nc2cccc3ncccc23)s1 nan
CHEMBL1485168 47538 7 None 1 3 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 304 3 1 4 3.4 Cc1ccc(S(=O)(=O)Nc2cccc3ncccc23)s1 nan
51057916 69231 2 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 373 3 1 2 6.4 Cc1cc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1779893 69231 2 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 373 3 1 2 6.4 Cc1cc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
82533 47818 70 None 2 5 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 298 3 1 3 3.3 Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)cc1 nan
CHEMBL1487635 47818 70 None 2 5 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 298 3 1 3 3.3 Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)cc1 nan
56682427 71928 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 332 3 1 2 5.2 Cc1ccc(C)c(-c2ccc(C(=O)Nc3c(C)cccc3C)n2C)c1 10.1016/j.bmcl.2011.06.132
CHEMBL1824253 71928 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 332 3 1 2 5.2 Cc1ccc(C)c(-c2ccc(C(=O)Nc3c(C)cccc3C)n2C)c1 10.1016/j.bmcl.2011.06.132
54580603 69247 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 319 3 1 2 5.4 Cc1ccc(C)c(-c2ccc(C(=O)Nc3c(C)cccc3C)o2)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1779911 69247 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 319 3 1 2 5.4 Cc1ccc(C)c(-c2ccc(C(=O)Nc3c(C)cccc3C)o2)c1 10.1016/j.bmcl.2011.04.097
54580603 69247 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 319 3 1 2 5.4 Cc1ccc(C)c(-c2ccc(C(=O)Nc3c(C)cccc3C)o2)c1 10.1016/j.bmcl.2011.06.132
CHEMBL1779911 69247 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 319 3 1 2 5.4 Cc1ccc(C)c(-c2ccc(C(=O)Nc3c(C)cccc3C)o2)c1 10.1016/j.bmcl.2011.06.132
54580601 69236 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 367 3 1 2 5.8 O=C(Nc1c(F)cccc1F)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779898 69236 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 367 3 1 2 5.8 O=C(Nc1c(F)cccc1F)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
14286542 78995 3 None 4 4 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 401 2 3 4 2.9 CC1=CC2/C=C(\C)CCC(O)C(O)/C=C/C(=O)C23C(=O)NC(CC(C)C)C3C1C nan
CHEMBL1981103 78995 3 None 4 4 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 401 2 3 4 2.9 CC1=CC2/C=C(\C)CCC(O)C(O)/C=C/C(=O)C23C(=O)NC(CC(C)C)C3C1C nan
4019447 26306 6 None 1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 386 5 1 7 2.4 COc1cc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)c(C)cc1[N+](=O)[O-] nan
CHEMBL1299526 26306 6 None 1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 386 5 1 7 2.4 COc1cc(NC(=O)Cn2ncc(Cl)c(Cl)c2=O)c(C)cc1[N+](=O)[O-] nan
2017227 36383 8 None 10 3 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 360 3 0 3 4.9 CC(=O)n1cc(N(C(=O)CCl)c2ccc(Cl)cc2)c2ccccc21 nan
CHEMBL1385784 36383 8 None 10 3 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 360 3 0 3 4.9 CC(=O)n1cc(N(C(=O)CCl)c2ccc(Cl)cc2)c2ccccc21 nan
11957208 62974 3 None 5 4 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 336 3 1 3 3.9 COC(=O)c1ccc2c(c1)C(C)(C)C(/C=C/c1ccc(O)cc1)=[N+]2C nan
CHEMBL1340713 62974 3 None 5 4 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 336 3 1 3 3.9 COC(=O)c1ccc2c(c1)C(C)(C)C(/C=C/c1ccc(O)cc1)=[N+]2C nan
CHEMBL1626334 62974 3 None 5 4 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 336 3 1 3 3.9 COC(=O)c1ccc2c(c1)C(C)(C)C(/C=C/c1ccc(O)cc1)=[N+]2C nan
2801236 86963 7 None 7 3 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 294 4 0 6 1.8 COc1ccc([N+](=O)[O-])c(S(=O)(=O)c2ccccc2)n1 nan
CHEMBL213580 86963 7 None 7 3 Human 6.2 pIC50 = 6.2 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 294 4 0 6 1.8 COc1ccc([N+](=O)[O-])c(S(=O)(=O)c2ccccc2)n1 nan
12005127 51580 4 None 3 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 333 6 0 4 4.6 COc1cc(/C=C(/C)[N+](=O)[O-])ccc1OCc1ccccc1Cl nan
CHEMBL1521989 51580 4 None 3 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 333 6 0 4 4.6 COc1cc(/C=C(/C)[N+](=O)[O-])ccc1OCc1ccccc1Cl nan
6526694 34378 3 None 7 5 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 364 4 1 3 5.7 O=C(/C(=C/c1ccc(Cl)cc1)c1nc2ccccc2[nH]1)c1cccs1 nan
CHEMBL1369594 34378 3 None 7 5 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 364 4 1 3 5.7 O=C(/C(=C/c1ccc(Cl)cc1)c1nc2ccccc2[nH]1)c1cccs1 nan
53388308 71934 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 329 3 1 1 5.8 Cc1ccc(C)c(-c2cccc(C(=O)Nc3c(C)cccc3C)c2)c1 10.1016/j.bmcl.2011.06.132
CHEMBL1824259 71934 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 329 3 1 1 5.8 Cc1ccc(C)c(-c2cccc(C(=O)Nc3c(C)cccc3C)c2)c1 10.1016/j.bmcl.2011.06.132
1218173 59578 8 None 3 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 319 2 0 5 2.9 O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1c1ccccn1 nan
CHEMBL1595015 59578 8 None 3 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 319 2 0 5 2.9 O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1c1ccccn1 nan
5759185 45451 5 None 4 5 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 300 4 0 6 2.8 CC(C)(C)C(=O)/C(=C\c1cccc([N+](=O)[O-])c1)n1cncn1 nan
CHEMBL1465592 45451 5 None 4 5 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 300 4 0 6 2.8 CC(C)(C)C(=O)/C(=C\c1cccc([N+](=O)[O-])c1)n1cncn1 nan
1336753 36937 14 None 7 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 403 4 1 6 3.9 O=[N+]([O-])c1cc(S(=O)(=O)C(F)(F)F)ccc1Sc1nc2ccccc2[nH]1 nan
CHEMBL1390139 36937 14 None 7 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 403 4 1 6 3.9 O=[N+]([O-])c1cc(S(=O)(=O)C(F)(F)F)ccc1Sc1nc2ccccc2[nH]1 nan
4492589 37681 6 None 102 4 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1397874 37681 6 None 102 4 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
4492589 37681 6 None 102 4 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.06.132
CHEMBL1397874 37681 6 None 102 4 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 359 3 1 2 6.1 Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.06.132
11957215 62531 3 None 3 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 336 3 1 3 3.9 COC(=O)c1ccc2c(c1)C(C)(C)C(/C=C/c1ccccc1O)=[N+]2C nan
CHEMBL1503962 62531 3 None 3 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 336 3 1 3 3.9 COC(=O)c1ccc2c(c1)C(C)(C)C(/C=C/c1ccccc1O)=[N+]2C nan
CHEMBL1622468 62531 3 None 3 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 336 3 1 3 3.9 COC(=O)c1ccc2c(c1)C(C)(C)C(/C=C/c1ccccc1O)=[N+]2C nan
54582606 69232 0 None 35 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 389 4 1 3 6.1 COc1cc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1779894 69232 0 None 35 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 389 4 1 3 6.1 COc1cc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
54586461 69230 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 387 3 0 2 6.5 Cc1cc(C)c(N(C)C(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1779892 69230 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 387 3 0 2 6.5 Cc1cc(C)c(N(C)C(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
2328694 60502 3 None 8 5 Human 7.1 pIC50 = 7.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 408 6 2 3 5.2 O=C(Nc1ccccc1)Nc1cc(OCC(F)(F)F)cc(OCC(F)(F)F)c1 nan
CHEMBL1603615 60502 3 None 8 5 Human 7.1 pIC50 = 7.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 408 6 2 3 5.2 O=C(Nc1ccccc1)Nc1cc(OCC(F)(F)F)cc(OCC(F)(F)F)c1 nan
1472218 34386 13 None -1 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 400 6 1 5 3.3 COc1ccc(NC(=O)/C(Cl)=C(/Cl)S(=O)(=O)Cc2ccccc2)cn1 nan
CHEMBL1369655 34386 13 None -1 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 400 6 1 5 3.3 COc1ccc(NC(=O)/C(Cl)=C(/Cl)S(=O)(=O)Cc2ccccc2)cn1 nan
2219262 41420 11 None 4 3 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 388 6 0 6 2.9 CCOC(=O)CCS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
CHEMBL1429929 41420 11 None 4 3 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 388 6 0 6 2.9 CCOC(=O)CCS(=O)(=O)c1nc(-c2ccccc2)cc(C(F)(F)F)n1 nan
706322 29930 9 None - 1 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 295 4 2 2 4.5 Cc1cc(NC(=O)/C=C/c2ccccc2)c(C(C)C)cc1O nan
CHEMBL1331049 29930 9 None - 1 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 295 4 2 2 4.5 Cc1cc(NC(=O)/C=C/c2ccccc2)c(C(C)C)cc1O nan
1475343 41695 14 None 2 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 430 7 1 6 3.3 COc1ccc(CS(=O)(=O)/C(Cl)=C(/Cl)C(=O)Nc2ccc(OC)nc2)cc1 nan
CHEMBL1432251 41695 14 None 2 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 430 7 1 6 3.3 COc1ccc(CS(=O)(=O)/C(Cl)=C(/Cl)C(=O)Nc2ccc(OC)nc2)cc1 nan
100520 39499 6 None 4 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 240 3 0 7 2.0 O=[N+]([O-])c1cnc(Sc2ccncn2)s1 nan
CHEMBL1413680 39499 6 None 4 4 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 240 3 0 7 2.0 O=[N+]([O-])c1cnc(Sc2ccncn2)s1 nan
367432 33522 12 None 15 3 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 326 5 0 4 3.0 CCOC(=O)C(=Cc1ccc(Br)cc1)C(=O)OCC nan
CHEMBL1362503 33522 12 None 15 3 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 326 5 0 4 3.0 CCOC(=O)C(=Cc1ccc(Br)cc1)C(=O)OCC nan
1474490 30433 16 None -3 3 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 422 3 0 5 2.9 O=C(OCn1ncc(Br)c(Br)c1=O)c1c(F)cccc1F nan
CHEMBL1334984 30433 16 None -3 3 Human 6.1 pIC50 = 6.1 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 422 3 0 5 2.9 O=C(OCn1ncc(Br)c(Br)c1=O)c1c(F)cccc1F nan
1474490 30433 16 None -3 3 Human 4.1 pIC50 = 4.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 422 3 0 5 2.9 O=C(OCn1ncc(Br)c(Br)c1=O)c1c(F)cccc1F nan
CHEMBL1334984 30433 16 None -3 3 Human 4.1 pIC50 = 4.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 422 3 0 5 2.9 O=C(OCn1ncc(Br)c(Br)c1=O)c1c(F)cccc1F nan
44607580 28303 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 387 5 1 2 6.6 CCc1cccc(CC)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1316334 28303 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 387 5 1 2 6.6 CCc1cccc(CC)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 10.1016/j.bmcl.2011.04.097
44607580 28303 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 387 5 1 2 6.6 CCc1cccc(CC)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
CHEMBL1316334 28303 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues. (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 2332 (Dose response screen (S1P4 antagonists)), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 387 5 1 2 6.6 CCc1cccc(CC)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 nan
56679130 71933 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 333 3 1 2 5.7 Cc1ccc(C)c(-c2oc(C(=O)Nc3c(C)cccc3C)cc2C)c1 10.1016/j.bmcl.2011.06.132
CHEMBL1824258 71933 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assayAntagonist activity at human S1P4 receptor expressed in EDG6-bla U2OS cells coexpressing human endothelial differentiation gene 6 linked to GAL4-VP16 assessed as beta-lactamase expression by FRET assay
ChEMBL 333 3 1 2 5.7 Cc1ccc(C)c(-c2oc(C(=O)Nc3c(C)cccc3C)cc2C)c1 10.1016/j.bmcl.2011.06.132
2295300 43192 10 None 3 5 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 356 8 1 5 3.7 CCOc1cc(/C=C\[N+](=O)[O-])ccc1OCC(=O)Nc1ccccc1C nan
CHEMBL1446971 43192 10 None 3 5 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 356 8 1 5 3.7 CCOc1cc(/C=C\[N+](=O)[O-])ccc1OCC(=O)Nc1ccccc1C nan
54583567 69251 0 None 28 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 311 3 1 3 5.2 Cc1ccsc1-c1ccc(C(=O)Nc2c(C)cccc2C)o1 10.1016/j.bmcl.2011.04.097
CHEMBL1779916 69251 0 None 28 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 311 3 1 3 5.2 Cc1ccsc1-c1ccc(C(=O)Nc2c(C)cccc2C)o1 10.1016/j.bmcl.2011.04.097
54584547 69235 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 4 1 3 5.8 COc1ccc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1779897 69235 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 375 4 1 3 5.8 COc1ccc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c1 10.1016/j.bmcl.2011.04.097
54580602 69240 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 430 5 2 3 5.8 CC(=O)NCc1cc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
CHEMBL1779902 69240 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assayAntagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TEV protease fusion protein and beta-lactamase reporter gene assessed as beta-lactamase expression by FRET assay
ChEMBL 430 5 2 3 5.8 CC(=O)NCc1cc(C)c(NC(=O)c2ccc(-c3cc(Cl)ccc3Cl)o2)c(C)c1 10.1016/j.bmcl.2011.04.097
2215161 47732 5 None 4 3 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 282 5 0 7 0.9 CCCS(=O)(=O)c1nnnn1-c1cccc(OC)c1 nan
CHEMBL1486934 47732 5 None 4 3 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 282 5 0 7 0.9 CCCS(=O)(=O)c1nnnn1-c1cccc(OC)c1 nan
5286552 33441 8 None 3 3 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 251 6 0 5 1.9 CCOC(=O)COc1ccccc1/C=C\[N+](=O)[O-] nan
CHEMBL1361821 33441 8 None 3 3 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 251 6 0 5 1.9 CCOC(=O)COc1ccccc1/C=C\[N+](=O)[O-] nan
5516000 43744 8 None 1 4 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 512 7 1 5 5.8 O=C(NCc1cccnc1)/C(=C\c1ccc(-c2ccc(Cl)c(Cl)c2)o1)S(=O)(=O)c1ccccc1 nan
CHEMBL1451470 43744 8 None 1 4 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 512 7 1 5 5.8 O=C(NCc1cccnc1)/C(=C\c1ccc(-c2ccc(Cl)c(Cl)c2)o1)S(=O)(=O)c1ccccc1 nan
3270222 43622 6 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 312 4 0 6 1.6 CCCC(=O)N(C1CC(C)C(C#N)(C#N)C1(C#N)C#N)N(C)C nan
CHEMBL1450393 43622 6 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)]
ChEMBL 312 4 0 6 1.6 CCCC(=O)N(C1CC(C)C(C#N)(C#N)C1(C#N)C#N)N(C)C nan
238775 49581 2 None 2 2 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 288 4 0 3 3.0 O=C(C=C=Nc1ccccc1)C(=O)N=C=Cc1ccccc1 nan
CHEMBL1502358 49581 2 None 2 2 Human 6.0 pIC50 = 6.0 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 288 4 0 3 3.0 O=C(C=C=Nc1ccccc1)C(=O)N=C=Cc1ccccc1 nan
3245258 41552 1 None 3 3 Human 6.0 pIC50 = 6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 308 2 0 5 2.6 CS(=O)(=O)c1nc(-c2cccs2)cc(C(F)(F)F)n1 nan
CHEMBL1430895 41552 1 None 3 3 Human 6.0 pIC50 = 6 Functional
PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]
ChEMBL 308 2 0 5 2.6 CS(=O)(=O)c1nc(-c2cccs2)cc(C(F)(F)F)n1 nan
49848557 7884 0 None -15848 5 Human 4.4 pEC50 < 4.4 Functional
In an aequorin calcium accumulation assay.In an aequorin calcium accumulation assay.
Guide to Pharmacology 461 7 1 8 4.0 OC(=O)CCN1CCc2c(C1)c(C)n(n2)c1nnc(s1)c1ccc(c(c1)Cl)OC(C)C 26751273
9492 7884 0 None -15848 5 Human 4.4 pEC50 < 4.4 Functional
In an aequorin calcium accumulation assay.In an aequorin calcium accumulation assay.
Guide to Pharmacology 461 7 1 8 4.0 OC(=O)CCN1CCc2c(C1)c(C)n(n2)c1nnc(s1)c1ccc(c(c1)Cl)OC(C)C 26751273
CHEMBL3769933 7884 0 None -15848 5 Human 4.4 pEC50 < 4.4 Functional
In an aequorin calcium accumulation assay.In an aequorin calcium accumulation assay.
Guide to Pharmacology 461 7 1 8 4.0 OC(=O)CCN1CCc2c(C1)c(C)n(n2)c1nnc(s1)c1ccc(c(c1)Cl)OC(C)C 26751273
52938427 9758 55 None -1174 5 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
Drug Central 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C None
5383 9758 55 None -1174 5 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
Drug Central 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C None
8709 9758 55 None -1174 5 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
Drug Central 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C None
CHEMBL3707247 9758 55 None -1174 5 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
Drug Central 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C None
DB12612 9758 55 None -1174 5 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrsAgonist activity at human S1P4 expressed in bla TANGO U2OS cells assessed as inhibition of cAMP formation preincubated for 4 hrs followed by FRET-based beta-lactamase fluorescent substrate addition measured after 2 hrs
Drug Central 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C None
11363176 9923 47 None -11 4 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 460 8 2 6 4.3 CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C None
5446 9923 47 None -11 4 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 460 8 2 6 4.3 CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C None
9320 9923 47 None -11 4 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 460 8 2 6 4.3 CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C None
CHEMBL1096146 9923 47 None -11 4 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 460 8 2 6 4.3 CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C None
DB12016 9923 47 None -11 4 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 460 8 2 6 4.3 CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C None
44599207 10381 43 None -257 5 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C None
5326 10381 43 None -257 5 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C None
9289 10381 43 None -257 5 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C None
CHEMBL2336071 10381 43 None -257 5 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C None
DB12371 10381 43 None -257 5 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C None
107970 8420 83 None 23 4 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
Drug Central 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N None
2407 8420 83 None 23 4 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
Drug Central 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N None
4167 8420 83 None 23 4 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
Drug Central 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N None
CHEMBL314854 8420 83 None 23 4 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
Drug Central 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N None
DB08868 8420 83 None 23 4 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
Drug Central 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N None
44623998 8377 38 None -457 8 Human 6.8 pEC50 = 6.8 Functional
In a &beta;-arrestin recruitment assay.In a &beta;-arrestin recruitment assay.
Guide to Pharmacology 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 12110609
44623998 8377 38 None -457 8 Human 6.8 pEC50 = 6.8 Functional
In a &beta;-arrestin recruitment assay.In a &beta;-arrestin recruitment assay.
Guide to Pharmacology 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 25516790
9331 8377 38 None -457 8 Human 6.8 pEC50 = 6.8 Functional
In a &beta;-arrestin recruitment assay.In a &beta;-arrestin recruitment assay.
Guide to Pharmacology 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 12110609
9331 8377 38 None -457 8 Human 6.8 pEC50 = 6.8 Functional
In a &beta;-arrestin recruitment assay.In a &beta;-arrestin recruitment assay.
Guide to Pharmacology 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 25516790
CHEMBL3358920 8377 38 None -457 8 Human 6.8 pEC50 = 6.8 Functional
In a &beta;-arrestin recruitment assay.In a &beta;-arrestin recruitment assay.
Guide to Pharmacology 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 12110609
CHEMBL3358920 8377 38 None -457 8 Human 6.8 pEC50 = 6.8 Functional
In a &beta;-arrestin recruitment assay.In a &beta;-arrestin recruitment assay.
Guide to Pharmacology 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 25516790
DB14766 8377 38 None -457 8 Human 6.8 pEC50 = 6.8 Functional
In a &beta;-arrestin recruitment assay.In a &beta;-arrestin recruitment assay.
Guide to Pharmacology 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 12110609
DB14766 8377 38 None -457 8 Human 6.8 pEC50 = 6.8 Functional
In a &beta;-arrestin recruitment assay.In a &beta;-arrestin recruitment assay.
Guide to Pharmacology 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 25516790
44599207 10381 43 None -257 5 Human 6.1 pEC50 = 6.1 Functional
In a GTP&gamma;S binding assayIn a GTP&gamma;S binding assay
Guide to Pharmacology 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 24125884
5326 10381 43 None -257 5 Human 6.1 pEC50 = 6.1 Functional
In a GTP&gamma;S binding assayIn a GTP&gamma;S binding assay
Guide to Pharmacology 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 24125884
9289 10381 43 None -257 5 Human 6.1 pEC50 = 6.1 Functional
In a GTP&gamma;S binding assayIn a GTP&gamma;S binding assay
Guide to Pharmacology 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 24125884
CHEMBL2336071 10381 43 None -257 5 Human 6.1 pEC50 = 6.1 Functional
In a GTP&gamma;S binding assayIn a GTP&gamma;S binding assay
Guide to Pharmacology 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 24125884
DB12371 10381 43 None -257 5 Human 6.1 pEC50 = 6.1 Functional
In a GTP&gamma;S binding assayIn a GTP&gamma;S binding assay
Guide to Pharmacology 516 9 1 4 6.8 CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C 24125884
16755143 7290 0 None -309 4 Human 5.6 pEC50 = 5.6 Functional
In a GTP&gamma;S binding assay.In a GTP&gamma;S binding assay.
Guide to Pharmacology 442 4 1 5 5.6 C[C@@H](C(F)(F)F)Oc1ccc(cc1C(F)(F)F)c1onc(n1)c1ccc2c(c1)nc[nH]2 25347187
9569 7290 0 None -309 4 Human 5.6 pEC50 = 5.6 Functional
In a GTP&gamma;S binding assay.In a GTP&gamma;S binding assay.
Guide to Pharmacology 442 4 1 5 5.6 C[C@@H](C(F)(F)F)Oc1ccc(cc1C(F)(F)F)c1onc(n1)c1ccc2c(c1)nc[nH]2 25347187
CHEMBL4297350 7290 0 None -309 4 Human 5.6 pEC50 = 5.6 Functional
In a GTP&gamma;S binding assay.In a GTP&gamma;S binding assay.
Guide to Pharmacology 442 4 1 5 5.6 C[C@@H](C(F)(F)F)Oc1ccc(cc1C(F)(F)F)c1onc(n1)c1ccc2c(c1)nc[nH]2 25347187
DB11819 7290 0 None -309 4 Human 5.6 pEC50 = 5.6 Functional
In a GTP&gamma;S binding assay.In a GTP&gamma;S binding assay.
Guide to Pharmacology 442 4 1 5 5.6 C[C@@H](C(F)(F)F)Oc1ccc(cc1C(F)(F)F)c1onc(n1)c1ccc2c(c1)nc[nH]2 25347187
124221654 7907 1 None 2 2 Human 6.7 pEC50 = 6.7 Functional
In a GTP&gamma;S binding assay.In a GTP&gamma;S binding assay.
Guide to Pharmacology 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 27894870
9495 7907 1 None 2 2 Human 6.7 pEC50 = 6.7 Functional
In a GTP&gamma;S binding assay.In a GTP&gamma;S binding assay.
Guide to Pharmacology 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 27894870
CHEMBL3884038 7907 1 None 2 2 Human 6.7 pEC50 = 6.7 Functional
In a GTP&gamma;S binding assay.In a GTP&gamma;S binding assay.
Guide to Pharmacology 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 27894870
124221654 7907 1 None 2 2 Human 6.8 pEC50 = 6.8 Functional
In a cAMP assay.In a cAMP assay.
Guide to Pharmacology 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 27894870
9495 7907 1 None 2 2 Human 6.8 pEC50 = 6.8 Functional
In a cAMP assay.In a cAMP assay.
Guide to Pharmacology 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 27894870
CHEMBL3884038 7907 1 None 2 2 Human 6.8 pEC50 = 6.8 Functional
In a cAMP assay.In a cAMP assay.
Guide to Pharmacology 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 27894870
10883396 10421 45 None -69 15 Mouse 7.1 pEC50 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 14732717
5283560 10421 45 None -69 15 Mouse 7.1 pEC50 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 14732717
911 10421 45 None -69 15 Mouse 7.1 pEC50 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 14732717
CHEMBL225155 10421 45 None -69 15 Mouse 7.1 pEC50 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 14732717
2924 8421 43 None -128 7 Mouse 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 11967257
2924 8421 43 None -128 7 Mouse 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 17898319
44398069 8421 43 None -128 7 Mouse 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 11967257
44398069 8421 43 None -128 7 Mouse 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 17898319
9908268 8421 43 None -128 7 Mouse 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 11967257
9908268 8421 43 None -128 7 Mouse 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 17898319
CHEMBL114606 8421 43 None -128 7 Mouse 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 11967257
CHEMBL114606 8421 43 None -128 7 Mouse 7.2 pEC50 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 17898319
10311 8076 37 None 37 2 Human 7.3 pEC50 = 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 405 5 0 5 3.9 COCCN=C1S/C(=C\c2cc(n(c2C)c2ccc(cc2F)F)C)/C(=O)N1C 21982495
49835928 8076 37 None 37 2 Human 7.3 pEC50 = 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 405 5 0 5 3.9 COCCN=C1S/C(=C\c2cc(n(c2C)c2ccc(cc2F)F)C)/C(=O)N1C 21982495
CHEMBL1910803 8076 37 None 37 2 Human 7.3 pEC50 = 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 405 5 0 5 3.9 COCCN=C1S/C(=C\c2cc(n(c2C)c2ccc(cc2F)F)C)/C(=O)N1C 21982495
10883396 10421 45 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 12270137
10883396 10421 45 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 14732717
10883396 10421 45 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 17114004
5283560 10421 45 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 12270137
5283560 10421 45 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 14732717
5283560 10421 45 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 17114004
911 10421 45 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 12270137
911 10421 45 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 14732717
911 10421 45 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 17114004
CHEMBL225155 10421 45 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 12270137
CHEMBL225155 10421 45 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 14732717
CHEMBL225155 10421 45 None -21 15 Human 7.6 pEC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 17114004
6992 10781 0 None -7 2 Human 7.8 pEC50 = 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 369 11 3 3 4.3 CCCCCCCCc1cccc(c1)C1CC(C1)(N)COP(=O)(O)O 21632869
73755254 10781 0 None -7 2 Human 7.8 pEC50 = 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 369 11 3 3 4.3 CCCCCCCCc1cccc(c1)C1CC(C1)(N)COP(=O)(O)O 21632869
2924 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 11967257
2924 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 14732717
2924 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 14747617
2924 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 17114004
2924 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 25347187
44398069 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 11967257
44398069 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 14732717
44398069 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 14747617
44398069 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 17114004
44398069 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 25347187
9908268 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 11967257
9908268 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 14732717
9908268 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 14747617
9908268 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 17114004
9908268 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 25347187
CHEMBL114606 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 11967257
CHEMBL114606 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 14732717
CHEMBL114606 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 14747617
CHEMBL114606 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 17114004
CHEMBL114606 8421 43 None -6 7 Human 7.9 pEC50 = 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 25347187
10904818 7091 0 None -1 4 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 373 13 3 4 3.8 CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C 11967257
10904818 7091 0 None -1 4 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 373 13 3 4 3.8 CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C 14732717
2937 7091 0 None -1 4 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 373 13 3 4 3.8 CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C 11967257
2937 7091 0 None -1 4 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 373 13 3 4 3.8 CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C 14732717
CHEMBL382739 7091 0 None -1 4 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 373 13 3 4 3.8 CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C 11967257
CHEMBL382739 7091 0 None -1 4 Human 8.4 pEC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 373 13 3 4 3.8 CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C 14732717
52938427 9758 55 None -1174 5 Human 5.1 pEC50 > 5.1 Functional
In a &beta;-arrestin assay.In a &beta;-arrestin assay.
Guide to Pharmacology 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C 26990079
5383 9758 55 None -1174 5 Human 5.1 pEC50 > 5.1 Functional
In a &beta;-arrestin assay.In a &beta;-arrestin assay.
Guide to Pharmacology 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C 26990079
8709 9758 55 None -1174 5 Human 5.1 pEC50 > 5.1 Functional
In a &beta;-arrestin assay.In a &beta;-arrestin assay.
Guide to Pharmacology 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C 26990079
CHEMBL3707247 9758 55 None -1174 5 Human 5.1 pEC50 > 5.1 Functional
In a &beta;-arrestin assay.In a &beta;-arrestin assay.
Guide to Pharmacology 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C 26990079
DB12612 9758 55 None -1174 5 Human 5.1 pEC50 > 5.1 Functional
In a &beta;-arrestin assay.In a &beta;-arrestin assay.
Guide to Pharmacology 404 7 2 7 3.6 OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C 26990079
11259583 7312 17 None -3548 7 Mouse 5.5 pEC50 None 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 455 7 2 3 6.8 OC(=O)CCNCc1ccc2c(c1)cc(s2)c1ccc(c(c1)C(F)(F)F)c1ccccc1 17114004
2925 7312 17 None -3548 7 Mouse 5.5 pEC50 None 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 455 7 2 3 6.8 OC(=O)CCNCc1ccc2c(c1)cc(s2)c1ccc(c(c1)C(F)(F)F)c1ccccc1 17114004
CHEMBL4579553 7312 17 None -3548 7 Mouse 5.5 pEC50 None 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 455 7 2 3 6.8 OC(=O)CCNCc1ccc2c(c1)cc(s2)c1ccc(c(c1)C(F)(F)F)c1ccccc1 17114004
2923 9366 0 None -11 3 Mouse 8.0 pEC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 509 11 4 6 5.0 OCC(COP(=O)(O)O)(CCc1ccc(cc1Cl)Sc1cccc(c1)Oc1ccccc1)N 17898319
56947075 9366 0 None -11 3 Mouse 8.0 pEC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 509 11 4 6 5.0 OCC(COP(=O)(O)O)(CCc1ccc(cc1Cl)Sc1cccc(c1)Oc1ccccc1)N 17898319
67468687 9366 0 None -11 3 Mouse 8.0 pEC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 509 11 4 6 5.0 OCC(COP(=O)(O)O)(CCc1ccc(cc1Cl)Sc1cccc(c1)Oc1ccccc1)N 17898319
10312 8077 27 None 154 4 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 4 2 3 5.6 NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl 21570287
10312 8077 27 None 154 4 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 4 2 3 5.6 NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl 23913862
53358422 8077 27 None 154 4 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 4 2 3 5.6 NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl 21570287
53358422 8077 27 None 154 4 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 4 2 3 5.6 NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl 23913862
CHEMBL1779732 8077 27 None 154 4 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 4 2 3 5.6 NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl 21570287
CHEMBL1779732 8077 27 None 154 4 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 4 2 3 5.6 NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl 23913862
10883396 10421 45 None -21 15 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 11967257
10883396 10421 45 None -21 15 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 12270137
5283560 10421 45 None -21 15 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 11967257
5283560 10421 45 None -21 15 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 12270137
911 10421 45 None -21 15 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 11967257
911 10421 45 None -21 15 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 12270137
CHEMBL225155 10421 45 None -21 15 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 11967257
CHEMBL225155 10421 45 None -21 15 Human 6.6 pIC50 None 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 12270137
10430549 7834 39 None -114 4 Human 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 391 7 1 5 4.1 CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C 16190743
2929 7834 39 None -114 4 Human 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 391 7 1 5 4.1 CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C 16190743
CHEMBL194419 7834 39 None -114 4 Human 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 391 7 1 5 4.1 CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C 16190743
2921 8204 0 None 67 2 Human 8.0 pIC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 381 18 4 4 4.3 CCCCCCCCCCCCCCC[C@H]([C@H](COP(=O)(O)O)N)O 12270137
44317142 8204 0 None 67 2 Human 8.0 pIC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 381 18 4 4 4.3 CCCCCCCCCCCCCCC[C@H]([C@H](COP(=O)(O)O)N)O 12270137
644260 8204 0 None 67 2 Human 8.0 pIC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 381 18 4 4 4.3 CCCCCCCCCCCCCCC[C@H]([C@H](COP(=O)(O)O)N)O 12270137
CHEMBL78494 8204 0 None 67 2 Human 8.0 pIC50 None 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 381 18 4 4 4.3 CCCCCCCCCCCCCCC[C@H]([C@H](COP(=O)(O)O)N)O 12270137
10883829 9892 0 None - 1 Human 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 397 18 5 5 3.2 CCCCCCCCCCCCCC[C@H]([C@H]([C@H](COP(=O)(O)O)N)O)O 12270137
2922 9892 0 None - 1 Human 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 397 18 5 5 3.2 CCCCCCCCCCCCCC[C@H]([C@H]([C@H](COP(=O)(O)O)N)O)O 12270137
46891723 9892 0 None - 1 Human 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 397 18 5 5 3.2 CCCCCCCCCCCCCC[C@H]([C@H]([C@H](COP(=O)(O)O)N)O)O 12270137


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
107970 8420 83 None - 0 Human 9.5 pEC50 = 9.5 Binding
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
ChEMBL 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N 10.1016/j.bmcl.2013.09.058
2407 8420 83 None - 0 Human 9.5 pEC50 = 9.5 Binding
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
ChEMBL 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N 10.1016/j.bmcl.2013.09.058
4167 8420 83 None - 0 Human 9.5 pEC50 = 9.5 Binding
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
ChEMBL 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N 10.1016/j.bmcl.2013.09.058
CHEMBL314854 8420 83 None - 0 Human 9.5 pEC50 = 9.5 Binding
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
ChEMBL 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N 10.1016/j.bmcl.2013.09.058
DB08868 8420 83 None - 0 Human 9.5 pEC50 = 9.5 Binding
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
ChEMBL 307 12 3 3 3.2 CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N 10.1016/j.bmcl.2013.09.058
49868651 177927 1 None - 0 Human 9.3 pEC50 = 9.3 Binding
Agonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayAgonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assay
ChEMBL 542 8 2 8 5.3 O=C(O)C[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 10.1021/acs.jmedchem.6b00373
CHEMBL4458575 177927 1 None - 0 Human 9.3 pEC50 = 9.3 Binding
Agonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayAgonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assay
ChEMBL 542 8 2 8 5.3 O=C(O)C[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 10.1021/acs.jmedchem.6b00373
50925337 177231 10 None - 0 Human 9.0 pEC50 = 9.0 Binding
Agonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayAgonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assay
ChEMBL 528 7 2 8 4.9 O=C(O)[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 10.1021/acs.jmedchem.6b00373
CHEMBL4448752 177231 10 None - 0 Human 9.0 pEC50 = 9.0 Binding
Agonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayAgonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assay
ChEMBL 528 7 2 8 4.9 O=C(O)[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 10.1021/acs.jmedchem.6b00373
134131598 149048 0 None - 0 Human 6.0 pEC50 = 6 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 373 4 1 3 5.2 O=C(O)C1CN(Cc2cc3c(-c4ccc5ccccc5c4)cccc3s2)C1 10.1016/j.bmcl.2016.11.050
CHEMBL3884966 149048 0 None - 0 Human 6.0 pEC50 = 6 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 373 4 1 3 5.2 O=C(O)C1CN(Cc2cc3c(-c4ccc5ccccc5c4)cccc3s2)C1 10.1016/j.bmcl.2016.11.050
134130192 148982 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 6 2 3 5.5 CC(CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
CHEMBL3884134 148982 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 6 2 3 5.5 CC(CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
134131497 148925 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 353 7 2 3 4.9 CCc1ccccc1-c1cccc2sc(CNCC(C)C(=O)O)cc12 10.1016/j.bmcl.2016.11.050
CHEMBL3883549 148925 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 353 7 2 3 4.9 CCc1ccccc1-c1cccc2sc(CNCC(C)C(=O)O)cc12 10.1016/j.bmcl.2016.11.050
134130884 148928 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 389 8 2 3 6.1 O=C(O)CCCCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3883572 148928 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 389 8 2 3 6.1 O=C(O)CCCCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 10.1016/j.bmcl.2016.11.050
134130150 148917 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 376 6 3 4 4.2 NC(CNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
CHEMBL3883471 148917 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 376 6 3 4 4.2 NC(CNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
134131253 149071 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 367 9 2 3 5.5 CCc1ccccc1-c1cccc2sc(CNCCCCC(=O)O)cc12 10.1016/j.bmcl.2016.11.050
CHEMBL3885187 149071 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 367 9 2 3 5.5 CCc1ccccc1-c1cccc2sc(CNCCCCC(=O)O)cc12 10.1016/j.bmcl.2016.11.050
134130662 149052 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 6 2 3 5.5 CC(CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
CHEMBL3884995 149052 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 6 2 3 5.5 CC(CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
134131209 149096 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 7 2 3 6.4 CCc1ccccc1-c1cccc2cc(CNc3cccc(CC(=O)O)c3)sc12 10.1016/j.bmcl.2016.11.050
CHEMBL3885415 149096 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 7 2 3 6.4 CCc1ccccc1-c1cccc2cc(CNc3cccc(CC(=O)O)c3)sc12 10.1016/j.bmcl.2016.11.050
44394289 19181 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 383 11 4 4 3.7 CCCCCCCCc1ccc2[nH]c(C(C)(N)COP(=O)(O)O)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL1185803 19181 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 383 11 4 4 3.7 CCCCCCCCc1ccc2[nH]c(C(C)(N)COP(=O)(O)O)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL433593 19181 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 383 11 4 4 3.7 CCCCCCCCc1ccc2[nH]c(C(C)(N)COP(=O)(O)O)nc2c1 10.1016/j.bmcl.2004.07.030
134131399 149093 0 None - 0 Human 4.9 pEC50 = 4.9 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 339 7 2 3 4.8 Cc1ccccc1-c1cccc2cc(CNCCCC(=O)O)sc12 10.1016/j.bmcl.2016.11.050
CHEMBL3885401 149093 0 None - 0 Human 4.9 pEC50 = 4.9 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 339 7 2 3 4.8 Cc1ccccc1-c1cccc2cc(CNCCCC(=O)O)sc12 10.1016/j.bmcl.2016.11.050
44342331 18188 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 428 16 4 4 4.5 CCCCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL116953 18188 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 428 16 4 4 4.5 CCCCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL1180214 18188 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 428 16 4 4 4.5 CCCCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
134131067 148963 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 423 6 2 3 7.0 O=C(O)Cc1ccc(NCc2cc3cccc(-c4ccc5ccccc5c4)c3s2)cc1 10.1016/j.bmcl.2016.11.050
CHEMBL3883991 148963 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 423 6 2 3 7.0 O=C(O)Cc1ccc(NCc2cc3cccc(-c4ccc5ccccc5c4)c3s2)cc1 10.1016/j.bmcl.2016.11.050
44623998 8377 38 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 10.1021/ml500389m
9331 8377 38 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 10.1021/ml500389m
CHEMBL3358920 8377 38 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 10.1021/ml500389m
DB14766 8377 38 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 457 6 2 2 6.9 OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 10.1021/ml500389m
134130111 149081 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 347 5 2 3 4.9 O=C(O)CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3885275 149081 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 347 5 2 3 4.9 O=C(O)CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 10.1016/j.bmcl.2016.11.050
11682677 18554 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 395 12 4 4 4.1 CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL1181748 18554 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 395 12 4 4 4.1 CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL190865 18554 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 395 12 4 4 4.1 CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
44342339 18178 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 344 10 4 4 2.2 CCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL114031 18178 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 344 10 4 4 2.2 CCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL1180115 18178 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 344 10 4 4 2.2 CCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
44398076 19672 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 425 13 5 5 3.2 CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL1188968 19672 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 425 13 5 5 3.2 CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL537849 19672 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 425 13 5 5 3.2 CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
44394521 18533 1 None - 0 Human 5.8 pEC50 = 5.8 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 289 9 3 3 3.5 CCCCCCCCc1ccc2[nH]c([C@H](N)CO)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL1181640 18533 1 None - 0 Human 5.8 pEC50 = 5.8 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 289 9 3 3 3.5 CCCCCCCCc1ccc2[nH]c([C@H](N)CO)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL186815 18533 1 None - 0 Human 5.8 pEC50 = 5.8 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 289 9 3 3 3.5 CCCCCCCCc1ccc2[nH]c([C@H](N)CO)nc2c1 10.1016/j.bmcl.2004.07.030
134131071 148899 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 7 2 3 5.7 O=C(O)CCCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3883377 148899 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 7 2 3 5.7 O=C(O)CCCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 10.1016/j.bmcl.2016.11.050
44398012 19036 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 425 12 4 4 4.4 CCCCCCCCc1ccc(-c2c[nH]c(C(C)(N)COP(O)(O)=S)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL1184707 19036 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 425 12 4 4 4.4 CCCCCCCCc1ccc(-c2c[nH]c(C(C)(N)COP(O)(O)=S)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL364950 19036 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 425 12 4 4 4.4 CCCCCCCCc1ccc(-c2c[nH]c(C(C)(N)COP(O)(O)=S)n2)cc1 10.1016/j.bmcl.2005.05.097
134131075 148908 0 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 353 8 2 3 5.1 CCc1ccccc1-c1cccc2sc(CNCCCC(=O)O)cc12 10.1016/j.bmcl.2016.11.050
CHEMBL3883420 148908 0 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 353 8 2 3 5.1 CCc1ccccc1-c1cccc2sc(CNCCCC(=O)O)cc12 10.1016/j.bmcl.2016.11.050
134131081 148916 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 361 6 2 3 5.3 O=C(O)CCNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3883456 148916 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 361 6 2 3 5.3 O=C(O)CCNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 10.1016/j.bmcl.2016.11.050
44398170 18544 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 411 12 4 4 4.2 CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(O)(O)=S)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL1181688 18544 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 411 12 4 4 4.2 CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(O)(O)=S)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL188826 18544 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 411 12 4 4 4.2 CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(O)(O)=S)n2)cc1 10.1016/j.bmcl.2005.05.097
134131363 149028 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 393 7 2 3 5.5 O=C(O)CCCNCc1cc2cccc(-c3ccc(C(F)(F)F)cc3)c2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3884795 149028 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 393 7 2 3 5.5 O=C(O)CCCNCc1cc2cccc(-c3ccc(C(F)(F)F)cc3)c2s1 10.1016/j.bmcl.2016.11.050
134130292 149089 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 405 8 2 4 5.7 COc1ccc2cc(-c3cccc4cc(CNCCCC(=O)O)sc34)ccc2c1 10.1016/j.bmcl.2016.11.050
CHEMBL3885357 149089 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 405 8 2 4 5.7 COc1ccc2cc(-c3cccc4cc(CNCCCC(=O)O)sc34)ccc2c1 10.1016/j.bmcl.2016.11.050
134130114 149049 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 7 2 3 5.7 O=C(O)CCCNCc1cc2cccc(-c3cccc4ccccc34)c2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3884986 149049 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 7 2 3 5.7 O=C(O)CCCNCc1cc2cccc(-c3cccc4ccccc34)c2s1 10.1016/j.bmcl.2016.11.050
134130375 148980 0 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 339 7 2 3 4.8 Cc1ccc(-c2cccc3cc(CNCCCC(=O)O)sc23)cc1 10.1016/j.bmcl.2016.11.050
CHEMBL3884099 148980 0 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 339 7 2 3 4.8 Cc1ccc(-c2cccc3cc(CNCCCC(=O)O)sc23)cc1 10.1016/j.bmcl.2016.11.050
124221654 7907 1 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 10.1016/j.bmcl.2016.11.050
9495 7907 1 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 10.1016/j.bmcl.2016.11.050
CHEMBL3884038 7907 1 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 7 2 3 5.7 OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 10.1016/j.bmcl.2016.11.050
134130947 149007 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 8 2 3 6.2 O=C(O)CCCNCc1cc2cccc(-c3ccc(-c4ccccc4)cc3)c2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3884580 149007 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 8 2 3 6.2 O=C(O)CCCNCc1cc2cccc(-c3ccc(-c4ccccc4)cc3)c2s1 10.1016/j.bmcl.2016.11.050
134131381 149087 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 7 2 3 5.7 O=C(O)CCCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3885331 149087 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 375 7 2 3 5.7 O=C(O)CCCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 10.1016/j.bmcl.2016.11.050
59393720 9595 29 None - 1 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
ChEMBL 464 7 3 3 6.3 OC(=O)[C@@H](NC(=O)c1c(C)cc(cc1C)c1cccc(c1)N[C@@H](c1ccc(c(c1)C)Cl)C)C 10.1016/j.bmcl.2013.09.058
6997 9595 29 None - 1 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
ChEMBL 464 7 3 3 6.3 OC(=O)[C@@H](NC(=O)c1c(C)cc(cc1C)c1cccc(c1)N[C@@H](c1ccc(c(c1)C)Cl)C)C 10.1016/j.bmcl.2013.09.058
CHEMBL3086703 9595 29 None - 1 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin)
ChEMBL 464 7 3 3 6.3 OC(=O)[C@@H](NC(=O)c1c(C)cc(cc1C)c1cccc(c1)N[C@@H](c1ccc(c(c1)C)Cl)C)C 10.1016/j.bmcl.2013.09.058
134131475 148965 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 7 2 3 6.4 CCc1ccccc1-c1cccc2sc(CNc3ccc(CC(=O)O)cc3)cc12 10.1016/j.bmcl.2016.11.050
CHEMBL3883998 148965 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 7 2 3 6.4 CCc1ccccc1-c1cccc2sc(CNc3ccc(CC(=O)O)cc3)cc12 10.1016/j.bmcl.2016.11.050
49839234 124729 1 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 472 6 3 3 6.1 O=C(O)CC1NCCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)cc21 10.1016/j.bmcl.2014.11.089
CHEMBL3403619 124729 1 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 472 6 3 3 6.1 O=C(O)CC1NCCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)cc21 10.1016/j.bmcl.2014.11.089
10883396 10421 45 None - 4 Human 6.6 pEC50 = 6.6 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2005.05.097
5283560 10421 45 None - 4 Human 6.6 pEC50 = 6.6 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2005.05.097
911 10421 45 None - 4 Human 6.6 pEC50 = 6.6 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2005.05.097
CHEMBL225155 10421 45 None - 4 Human 6.6 pEC50 = 6.6 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2005.05.097
10883396 10421 45 None - 4 Human 6.6 pEC50 = 6.6 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/s0960-894x(03)00812-6
5283560 10421 45 None - 4 Human 6.6 pEC50 = 6.6 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/s0960-894x(03)00812-6
911 10421 45 None - 4 Human 6.6 pEC50 = 6.6 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/s0960-894x(03)00812-6
CHEMBL225155 10421 45 None - 4 Human 6.6 pEC50 = 6.6 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand (Experiment 2)
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/s0960-894x(03)00812-6
134131188 149076 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 354 7 3 4 3.6 CCc1ccccc1-c1cccc2cc(CNCC(N)C(=O)O)sc12 10.1016/j.bmcl.2016.11.050
CHEMBL3885229 149076 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 354 7 3 4 3.6 CCc1ccccc1-c1cccc2cc(CNCC(N)C(=O)O)sc12 10.1016/j.bmcl.2016.11.050
44394539 18523 0 None - 0 Human 4.5 pEC50 = 4.5 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 303 9 3 3 3.8 CCCCCCCCc1ccc2[nH]c([C@@H](N)[C@@H](C)O)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL1181600 18523 0 None - 0 Human 4.5 pEC50 = 4.5 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 303 9 3 3 3.8 CCCCCCCCc1ccc2[nH]c([C@@H](N)[C@@H](C)O)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL183888 18523 0 None - 0 Human 4.5 pEC50 = 4.5 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 303 9 3 3 3.8 CCCCCCCCc1ccc2[nH]c([C@@H](N)[C@@H](C)O)nc2c1 10.1016/j.bmcl.2004.07.030
134130066 149031 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 8 2 3 6.2 O=C(O)CCCNCc1cc2cccc(-c3cccc(-c4ccccc4)c3)c2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3884809 149031 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 8 2 3 6.2 O=C(O)CCCNCc1cc2cccc(-c3cccc(-c4ccccc4)c3)c2s1 10.1016/j.bmcl.2016.11.050
134131470 149073 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 7 2 3 6.4 CCc1ccccc1-c1cccc2cc(CNc3ccc(CC(=O)O)cc3)sc12 10.1016/j.bmcl.2016.11.050
CHEMBL3885195 149073 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 7 2 3 6.4 CCc1ccccc1-c1cccc2cc(CNc3ccc(CC(=O)O)cc3)sc12 10.1016/j.bmcl.2016.11.050
134130316 149100 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 347 5 2 3 4.9 O=C(O)CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3885468 149100 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 347 5 2 3 4.9 O=C(O)CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 10.1016/j.bmcl.2016.11.050
44394459 130415 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 497 11 4 6 4.3 CCCCCCCCc1ccc2[nH]c([C@H](N)COP(=O)(O)O)nc2c1.COC(=O)C(F)(F)F 10.1016/j.bmcl.2004.07.030
CHEMBL361915 130415 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 497 11 4 6 4.3 CCCCCCCCc1ccc2[nH]c([C@H](N)COP(=O)(O)O)nc2c1.COC(=O)C(F)(F)F 10.1016/j.bmcl.2004.07.030
10883396 10421 45 None - 4 Human 7.4 pEC50 = 7.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2004.07.030
5283560 10421 45 None - 4 Human 7.4 pEC50 = 7.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2004.07.030
911 10421 45 None - 4 Human 7.4 pEC50 = 7.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2004.07.030
CHEMBL225155 10421 45 None - 4 Human 7.4 pEC50 = 7.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2004.07.030
134130519 148959 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 361 6 2 3 5.3 O=C(O)CCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3883972 148959 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 361 6 2 3 5.3 O=C(O)CCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 10.1016/j.bmcl.2016.11.050
134131256 148955 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 369 7 2 5 4.3 O=C(O)CCCNCc1cc2cccc(-c3ccc4c(c3)OCO4)c2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3883947 148955 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 369 7 2 5 4.3 O=C(O)CCCNCc1cc2cccc(-c3ccc4c(c3)OCO4)c2s1 10.1016/j.bmcl.2016.11.050
44398058 18538 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 395 12 4 4 4.1 CCCCCCCCc1ccc(-c2c[nH]c([C@H](N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL1181660 18538 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 395 12 4 4 4.1 CCCCCCCCc1ccc(-c2c[nH]c([C@H](N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL187712 18538 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 395 12 4 4 4.1 CCCCCCCCc1ccc(-c2c[nH]c([C@H](N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
2924 8421 43 None - 0 Human 7.4 pEC50 = 7.4 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2005.05.097
44398069 8421 43 None - 0 Human 7.4 pEC50 = 7.4 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2005.05.097
9908268 8421 43 None - 0 Human 7.4 pEC50 = 7.4 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2005.05.097
CHEMBL114606 8421 43 None - 0 Human 7.4 pEC50 = 7.4 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2005.05.097
134129983 148926 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 389 8 2 3 6.1 O=C(O)CCCCNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3883555 148926 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 389 8 2 3 6.1 O=C(O)CCCCNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 10.1016/j.bmcl.2016.11.050
46174905 123066 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 457 6 1 3 6.9 O=C(O)CC1CCn2c1cc1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc12 10.1021/ml500422m
CHEMBL3358955 123066 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 457 6 1 3 6.9 O=C(O)CC1CCn2c1cc1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc12 10.1021/ml500422m
44394564 19030 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 289 9 3 3 3.5 CCCCCCCCc1ccc2[nH]c([C@@H](N)CO)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL1184660 19030 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 289 9 3 3 3.5 CCCCCCCCc1ccc2[nH]c([C@@H](N)CO)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL363076 19030 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 289 9 3 3 3.5 CCCCCCCCc1ccc2[nH]c([C@@H](N)CO)nc2c1 10.1016/j.bmcl.2004.07.030
134130546 148947 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 361 6 2 3 5.3 O=C(O)CCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3883812 148947 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 361 6 2 3 5.3 O=C(O)CCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 10.1016/j.bmcl.2016.11.050
10023913 18905 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 400 14 4 4 3.7 CCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL1184130 18905 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 400 14 4 4 3.7 CCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL334038 18905 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 400 14 4 4 3.7 CCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
134130145 148902 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 7 2 3 6.4 CCc1ccccc1-c1cccc2sc(CNc3cccc(CC(=O)O)c3)cc12 10.1016/j.bmcl.2016.11.050
CHEMBL3883399 148902 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 401 7 2 3 6.4 CCc1ccccc1-c1cccc2sc(CNc3cccc(CC(=O)O)c3)cc12 10.1016/j.bmcl.2016.11.050
44394497 73468 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 497 11 4 6 4.3 CCCCCCCCc1ccc2[nH]c([C@@H](N)COP(=O)(O)O)nc2c1.COC(=O)C(F)(F)F 10.1016/j.bmcl.2004.07.030
CHEMBL185491 73468 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 497 11 4 6 4.3 CCCCCCCCc1ccc2[nH]c([C@@H](N)COP(=O)(O)O)nc2c1.COC(=O)C(F)(F)F 10.1016/j.bmcl.2004.07.030
44342175 92295 0 None - 2 Human 6.3 pEC50 = 6.3 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL227371 92295 0 None - 2 Human 6.3 pEC50 = 6.3 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL422074 92295 0 None - 2 Human 6.3 pEC50 = 6.3 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
134131169 149041 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 381 7 2 3 5.8 CC(C)(C)c1ccc(-c2cccc3cc(CNCCCC(=O)O)sc23)cc1 10.1016/j.bmcl.2016.11.050
CHEMBL3884888 149041 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 381 7 2 3 5.8 CC(C)(C)c1ccc(-c2cccc3cc(CNCCCC(=O)O)sc23)cc1 10.1016/j.bmcl.2016.11.050
134130023 148989 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 376 6 3 4 4.2 NC(CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
CHEMBL3884173 148989 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 376 6 3 4 4.2 NC(CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
46174905 123066 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 457 6 1 3 6.9 O=C(O)CC1CCn2c1cc1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc12 10.1021/ml500422m
CHEMBL3358955 123066 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 457 6 1 3 6.9 O=C(O)CC1CCn2c1cc1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc12 10.1021/ml500422m
134130071 149036 0 None - 0 Human 4.2 pEC50 = 4.2 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 354 7 3 4 3.6 CCc1ccccc1-c1cccc2sc(CNCC(N)C(=O)O)cc12 10.1016/j.bmcl.2016.11.050
CHEMBL3884862 149036 0 None - 0 Human 4.2 pEC50 = 4.2 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 354 7 3 4 3.6 CCc1ccccc1-c1cccc2sc(CNCC(N)C(=O)O)cc12 10.1016/j.bmcl.2016.11.050
134130695 148914 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 347 5 2 3 4.9 O=C(O)CNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3883447 148914 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 347 5 2 3 4.9 O=C(O)CNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 10.1016/j.bmcl.2016.11.050
44398074 19658 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 345 11 4 4 3.1 CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)CO)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL1188885 19658 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 345 11 4 4 3.1 CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)CO)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL537632 19658 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 345 11 4 4 3.1 CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)CO)n2)cc1 10.1016/j.bmcl.2005.05.097
134130732 148972 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 393 7 2 3 5.5 O=C(O)CCCNCc1cc2cccc(-c3cccc(C(F)(F)F)c3)c2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3884056 148972 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 393 7 2 3 5.5 O=C(O)CCCNCc1cc2cccc(-c3cccc(C(F)(F)F)c3)c2s1 10.1016/j.bmcl.2016.11.050
134129958 149058 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 376 6 3 4 4.2 NC(CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
CHEMBL3885074 149058 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 376 6 3 4 4.2 NC(CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1)C(=O)O 10.1016/j.bmcl.2016.11.050
134131297 148935 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 389 8 2 3 6.1 O=C(O)CCCCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 10.1016/j.bmcl.2016.11.050
CHEMBL3883621 148935 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 389 8 2 3 6.1 O=C(O)CCCCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 10.1016/j.bmcl.2016.11.050
44398172 18551 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 315 10 3 3 4.0 CCCCCCCCc1ccc(-c2c[nH]c([C@H](N)CO)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL1181739 18551 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 315 10 3 3 4.0 CCCCCCCCc1ccc(-c2c[nH]c([C@H](N)CO)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL190529 18551 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 315 10 3 3 4.0 CCCCCCCCc1ccc(-c2c[nH]c([C@H](N)CO)n2)cc1 10.1016/j.bmcl.2005.05.097
134130571 148995 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 423 6 2 3 7.0 O=C(O)Cc1cccc(NCc2cc3cccc(-c4ccc5ccccc5c4)c3s2)c1 10.1016/j.bmcl.2016.11.050
CHEMBL3884292 148995 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 423 6 2 3 7.0 O=C(O)Cc1cccc(NCc2cc3cccc(-c4ccc5ccccc5c4)c3s2)c1 10.1016/j.bmcl.2016.11.050
53362086 123133 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 481 7 1 4 6.6 CC(C)Oc1ccc(COc2ccc3c(c2)c(Cl)c2n3CC[C@@H]2CC(=O)O)cc1C(F)(F)F 10.1021/ml500422m
CHEMBL3359523 123133 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 481 7 1 4 6.6 CC(C)Oc1ccc(COc2ccc3c(c2)c(Cl)c2n3CC[C@@H]2CC(=O)O)cc1C(F)(F)F 10.1021/ml500422m
67250226 123132 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 438 7 1 5 5.5 CC(C)Oc1ccc(COc2ccc3c(c2)c(Cl)c2n3CC[C@@H]2CC(=O)O)cc1C#N 10.1021/ml500422m
CHEMBL3359522 123132 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay
ChEMBL 438 7 1 5 5.5 CC(C)Oc1ccc(COc2ccc3c(c2)c(Cl)c2n3CC[C@@H]2CC(=O)O)cc1C#N 10.1021/ml500422m
44342219 18183 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 344 10 4 4 2.2 CCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL115344 18183 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 344 10 4 4 2.2 CCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL1180152 18183 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 344 10 4 4 2.2 CCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
44398049 19950 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 441 13 5 5 3.4 CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(O)(O)=S)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL1190950 19950 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 441 13 5 5 3.4 CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(O)(O)=S)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL541890 19950 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 441 13 5 5 3.4 CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(O)(O)=S)n2)cc1 10.1016/j.bmcl.2005.05.097
11675907 18548 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 409 12 4 4 4.3 CCCCCCCCc1ccc(-c2c[nH]c(C(C)(N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL1181694 18548 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 409 12 4 4 4.3 CCCCCCCCc1ccc(-c2c[nH]c(C(C)(N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
CHEMBL188881 18548 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
ChEMBL 409 12 4 4 4.3 CCCCCCCCc1ccc(-c2c[nH]c(C(C)(N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2005.05.097
44342468 18890 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL1184089 18890 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
CHEMBL332050 18890 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand
ChEMBL 372 12 4 4 3.0 CCCCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 10.1016/s0960-894x(03)00812-6
134130131 149065 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 339 7 2 3 4.8 Cc1cccc(-c2cccc3cc(CNCCCC(=O)O)sc23)c1 10.1016/j.bmcl.2016.11.050
CHEMBL3885151 149065 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method
ChEMBL 339 7 2 3 4.8 Cc1cccc(-c2cccc3cc(CNCCCC(=O)O)sc23)c1 10.1016/j.bmcl.2016.11.050
44394327 18524 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 383 11 4 4 4.0 CCCCCCCCc1ccc2[nH]c([C@@H](N)[C@@H](C)OP(=O)(O)O)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL1181601 18524 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 383 11 4 4 4.0 CCCCCCCCc1ccc2[nH]c([C@@H](N)[C@@H](C)OP(=O)(O)O)nc2c1 10.1016/j.bmcl.2004.07.030
CHEMBL183894 18524 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand
ChEMBL 383 11 4 4 4.0 CCCCCCCCc1ccc2[nH]c([C@@H](N)[C@@H](C)OP(=O)(O)O)nc2c1 10.1016/j.bmcl.2004.07.030
10883396 10421 45 None - 4 Human 9.0 pIC50 = 9.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2010.02.098
5283560 10421 45 None - 4 Human 9.0 pIC50 = 9.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2010.02.098
911 10421 45 None - 4 Human 9.0 pIC50 = 9.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2010.02.098
CHEMBL225155 10421 45 None - 4 Human 9.0 pIC50 = 9.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2010.02.098
44591265 186760 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 425 13 4 5 4.1 CCCCCCCCOc1ccc(-c2c[nH]c([C@@](C)(N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2008.11.072
CHEMBL474689 186760 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 425 13 4 5 4.1 CCCCCCCCOc1ccc(-c2c[nH]c([C@@](C)(N)COP(=O)(O)O)n2)cc1 10.1016/j.bmcl.2008.11.072
44565739 185739 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 459 12 4 5 4.2 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCCCCc3ccccc3)cc2)c[nH]1 10.1016/j.bmcl.2009.02.073
CHEMBL470511 185739 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 459 12 4 5 4.2 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCCCCc3ccccc3)cc2)c[nH]1 10.1016/j.bmcl.2009.02.073
10150171 174788 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 357 13 3 3 4.0 CCCCCCCCc1ccc(CCC(N)COP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL432067 174788 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 357 13 3 3 4.0 CCCCCCCCc1ccc(CCC(N)COP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
44591264 186758 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 420 13 4 5 3.3 CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)c(F)c1 10.1016/j.bmcl.2008.11.072
CHEMBL474688 186758 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 420 13 4 5 3.3 CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)c(F)c1 10.1016/j.bmcl.2008.11.072
44591266 186079 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 443 13 4 5 4.2 CCCCCCCCOc1ccc(-c2c[nH]c([C@@](C)(N)COP(=O)(O)O)n2)cc1F 10.1016/j.bmcl.2008.11.072
CHEMBL473269 186079 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 443 13 4 5 4.2 CCCCCCCCOc1ccc(-c2c[nH]c([C@@](C)(N)COP(=O)(O)O)n2)cc1F 10.1016/j.bmcl.2008.11.072
44565596 196325 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 422 11 4 5 2.9 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCc2ccccc2)cc1 10.1016/j.bmcl.2009.02.073
CHEMBL514302 196325 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 422 11 4 5 2.9 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCc2ccccc2)cc1 10.1016/j.bmcl.2009.02.073
11540052 187346 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 470 10 4 5 3.7 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2010.02.098
CHEMBL475405 187346 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 470 10 4 5 3.7 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2010.02.098
44412221 83885 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 391 6 2 5 4.5 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4CC[C@@H](C(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
CHEMBL207580 83885 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 391 6 2 5 4.5 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4CC[C@@H](C(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
44412233 84912 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 405 7 2 5 4.9 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4CC[C@@H](CC(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
CHEMBL210352 84912 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 405 7 2 5 4.9 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4CC[C@@H](CC(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
10174255 91992 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 485 6 1 6 5.7 O=C(O)C1CN(Cc2ccc(-c3noc(-c4cc(-c5ccccc5)c(C(F)(F)F)s4)n3)cc2)C1 10.1021/jm0492507
CHEMBL225575 91992 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 485 6 1 6 5.7 O=C(O)C1CN(Cc2ccc(-c3noc(-c4cc(-c5ccccc5)c(C(F)(F)F)s4)n3)cc2)C1 10.1021/jm0492507
44565738 196532 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 445 11 4 5 3.8 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCCCc3ccccc3)cc2)c[nH]1 10.1016/j.bmcl.2009.02.073
CHEMBL515917 196532 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 445 11 4 5 3.8 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCCCc3ccccc3)cc2)c[nH]1 10.1016/j.bmcl.2009.02.073
44413365 84157 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 467 6 2 5 5.8 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(C5CCC(F)(F)CC5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
CHEMBL208648 84157 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 467 6 2 5 5.8 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(C5CCC(F)(F)CC5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
44413447 145461 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 431 6 2 5 5.6 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
CHEMBL377828 145461 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 431 6 2 5 5.6 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
44413446 85125 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 417 6 2 5 5.2 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(C5CCCC5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
CHEMBL211006 85125 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 417 6 2 5 5.2 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(C5CCCC5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
11408903 91901 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 475 7 1 4 6.1 Cc1cc(CN2CC(C(=O)O)C2)cc(C)c1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 10.1021/jm0492507
CHEMBL224853 91901 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 475 7 1 4 6.1 Cc1cc(CN2CC(C(=O)O)C2)cc(C)c1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 10.1021/jm0492507
44394279 73924 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 375 16 3 2 5.8 CCCCCCCCCCCCCC[C@H]1CC[C@H](CCP(=O)(O)O)N1 10.1016/j.bmcl.2004.07.049
CHEMBL187588 73924 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 375 16 3 2 5.8 CCCCCCCCCCCCCC[C@H]1CC[C@H](CCP(=O)(O)O)N1 10.1016/j.bmcl.2004.07.049
10125862 18397 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 335 14 3 3 3.9 CCCCCCCCCc1ccc(CNCCC(O)C(=O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL118068 18397 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 335 14 3 3 3.9 CCCCCCCCCc1ccc(CNCCC(O)C(=O)O)cc1 10.1016/j.bmcl.2004.04.069
11690779 196494 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 442 8 4 5 3.9 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(Oc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
CHEMBL515603 196494 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 442 8 4 5 3.9 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(Oc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
11503967 14793 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 482 10 4 5 3.9 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(C(=O)CCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2010.02.098
CHEMBL1090796 14793 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 482 10 4 5 3.9 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(C(=O)CCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2010.02.098
10217498 91861 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 481 7 1 4 6.2 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(Cl)c2)C1 10.1021/jm0492507
CHEMBL224571 91861 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 481 7 1 4 6.2 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(Cl)c2)C1 10.1021/jm0492507
44344390 20269 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 15 3 2 4.5 O=P(O)(O)CCCNCCCCCCCCCCc1ccccc1 10.1016/j.bmcl.2004.04.069
CHEMBL119349 20269 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 15 3 2 4.5 O=P(O)(O)CCCNCCCCCCCCCCc1ccccc1 10.1016/j.bmcl.2004.04.069
10215138 20853 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 321 15 3 2 4.6 CCCCCCCCCCCCCC(N)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL119760 20853 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 321 15 3 2 4.6 CCCCCCCCCCCCCC(N)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
44344193 121690 5 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 335 17 3 2 4.8 CCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL334213 121690 5 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 335 17 3 2 4.8 CCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
44344193 121690 5 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 335 17 3 2 4.8 CCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1021/jm0492507
CHEMBL334213 121690 5 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 335 17 3 2 4.8 CCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1021/jm0492507
10172545 16397 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.4 CCCCCCCCc1ccc(CCC(N)C(O)CP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL112655 16397 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.4 CCCCCCCCc1ccc(CCC(N)C(O)CP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
44344193 121690 5 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 335 17 3 2 4.8 CCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.07.049
CHEMBL334213 121690 5 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 335 17 3 2 4.8 CCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.07.049
44341399 213746 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 724 25 7 5 7.9 CCCCCCCCc1ccc(CCC(N)/C=C/P(=O)(O)O)cc1.CCCCCCCCc1ccc(CCC(N)C(O)CP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL91283 213746 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 724 25 7 5 7.9 CCCCCCCCc1ccc(CCC(N)/C=C/P(=O)(O)O)cc1.CCCCCCCCc1ccc(CCC(N)C(O)CP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
10308738 17043 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 335 14 3 3 3.9 CCCCCCCCCc1ccc(CNCC(O)CC(=O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL116140 17043 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 335 14 3 3 3.9 CCCCCCCCCc1ccc(CNCC(O)CC(=O)O)cc1 10.1016/j.bmcl.2004.04.069
44344446 121599 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 349 17 3 2 5.4 CCCCCCCCCCCCCCCC(N)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL334144 121599 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 349 17 3 2 5.4 CCCCCCCCCCCCCCCC(N)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
44412428 85068 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 435 6 2 5 5.5 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc(C5CCCC5)cc4F)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
CHEMBL210782 85068 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 435 6 2 5 5.5 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc(C5CCCC5)cc4F)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
24812110 17522 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 373 13 4 4 3.3 CCCCCCCCc1ccc(CCC(N)(CO)OP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL117130 17522 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 373 13 4 4 3.3 CCCCCCCCc1ccc(CCC(N)(CO)OP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
2924 8421 43 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/jm0492507
44398069 8421 43 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/jm0492507
9908268 8421 43 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/jm0492507
CHEMBL114606 8421 43 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1021/jm0492507
2924 8421 43 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2004.02.106
44398069 8421 43 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2004.02.106
9908268 8421 43 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2004.02.106
CHEMBL114606 8421 43 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 387 14 4 4 3.3 CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N 10.1016/j.bmcl.2004.02.106
46905530 17064 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 389 14 5 6 2.6 CCCCCCCCc1ccc(CCC(N)(CO)CO[PH](O)(O)O)cc1 10.1016/j.bmcl.2004.07.049
CHEMBL1161691 17064 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 389 14 5 6 2.6 CCCCCCCCc1ccc(CCC(N)(CO)CO[PH](O)(O)O)cc1 10.1016/j.bmcl.2004.07.049
10317453 77193 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 377 7 1 5 3.9 CCCc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
CHEMBL194578 77193 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 377 7 1 5 3.9 CCCc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
11495139 145682 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 405 7 2 5 4.7 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4C[C@H](CC(=O)O)CN4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.090
CHEMBL378300 145682 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 405 7 2 5 4.7 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4C[C@H](CC(=O)O)CN4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.090
44394149 130805 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 377 15 3 3 4.5 CCCCCCCCCCCCCCN1CCC(C(O)P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
CHEMBL363008 130805 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 377 15 3 3 4.5 CCCCCCCCCCCCCCN1CCC(C(O)P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
44412165 84536 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 453 6 2 5 5.6 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
CHEMBL209076 84536 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 453 6 2 5 5.6 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
10288527 91804 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 461 7 1 4 5.8 Cc1cc(CN2CC(C(=O)O)C2)ccc1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 10.1021/jm0492507
CHEMBL224005 91804 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 461 7 1 4 5.8 Cc1cc(CN2CC(C(=O)O)C2)ccc1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 10.1021/jm0492507
10883396 10421 45 None - 4 Human 6.8 pIC50 = 6.8 Binding
Displacement of [32P]S1P from human recombinant S1PR4 incubated for 60 mins by competitive binding assay based scintillation counterDisplacement of [32P]S1P from human recombinant S1PR4 incubated for 60 mins by competitive binding assay based scintillation counter
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1039/d1md00357g
5283560 10421 45 None - 4 Human 6.8 pIC50 = 6.8 Binding
Displacement of [32P]S1P from human recombinant S1PR4 incubated for 60 mins by competitive binding assay based scintillation counterDisplacement of [32P]S1P from human recombinant S1PR4 incubated for 60 mins by competitive binding assay based scintillation counter
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1039/d1md00357g
911 10421 45 None - 4 Human 6.8 pIC50 = 6.8 Binding
Displacement of [32P]S1P from human recombinant S1PR4 incubated for 60 mins by competitive binding assay based scintillation counterDisplacement of [32P]S1P from human recombinant S1PR4 incubated for 60 mins by competitive binding assay based scintillation counter
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1039/d1md00357g
CHEMBL225155 10421 45 None - 4 Human 6.8 pIC50 = 6.8 Binding
Displacement of [32P]S1P from human recombinant S1PR4 incubated for 60 mins by competitive binding assay based scintillation counterDisplacement of [32P]S1P from human recombinant S1PR4 incubated for 60 mins by competitive binding assay based scintillation counter
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1039/d1md00357g
10883396 10421 45 None - 4 Human 6.8 pIC50 = 6.8 Binding
Displacement of [32P]S1P from recombinant human S1PR4 expressed in cell membranes pretreated for 30 mins followed by [32P]S1P addition measured after 60 mins by scintillation counting methodDisplacement of [32P]S1P from recombinant human S1PR4 expressed in cell membranes pretreated for 30 mins followed by [32P]S1P addition measured after 60 mins by scintillation counting method
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2017.12.010
5283560 10421 45 None - 4 Human 6.8 pIC50 = 6.8 Binding
Displacement of [32P]S1P from recombinant human S1PR4 expressed in cell membranes pretreated for 30 mins followed by [32P]S1P addition measured after 60 mins by scintillation counting methodDisplacement of [32P]S1P from recombinant human S1PR4 expressed in cell membranes pretreated for 30 mins followed by [32P]S1P addition measured after 60 mins by scintillation counting method
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2017.12.010
911 10421 45 None - 4 Human 6.8 pIC50 = 6.8 Binding
Displacement of [32P]S1P from recombinant human S1PR4 expressed in cell membranes pretreated for 30 mins followed by [32P]S1P addition measured after 60 mins by scintillation counting methodDisplacement of [32P]S1P from recombinant human S1PR4 expressed in cell membranes pretreated for 30 mins followed by [32P]S1P addition measured after 60 mins by scintillation counting method
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2017.12.010
CHEMBL225155 10421 45 None - 4 Human 6.8 pIC50 = 6.8 Binding
Displacement of [32P]S1P from recombinant human S1PR4 expressed in cell membranes pretreated for 30 mins followed by [32P]S1P addition measured after 60 mins by scintillation counting methodDisplacement of [32P]S1P from recombinant human S1PR4 expressed in cell membranes pretreated for 30 mins followed by [32P]S1P addition measured after 60 mins by scintillation counting method
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2017.12.010
10384596 16908 2 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@@H](N)C[C@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL115713 16908 2 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@@H](N)C[C@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
44341276 16878 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@@H](N)C[C@@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL115554 16878 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@@H](N)C[C@@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
44413430 145547 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 405 7 2 5 4.7 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4C[C@@H](CC(=O)O)CN4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.090
CHEMBL378061 145547 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 405 7 2 5 4.7 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4C[C@@H](CC(=O)O)CN4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.090
10127475 172808 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 447 7 1 4 5.5 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1016/j.bmcl.2006.03.090
CHEMBL425563 172808 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 447 7 1 4 5.5 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1016/j.bmcl.2006.03.090
10127475 172808 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 447 7 1 4 5.5 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1021/jm0492507
CHEMBL425563 172808 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 447 7 1 4 5.5 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1021/jm0492507
44394212 73944 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 373 15 2 2 6.5 CCCCCCCCCCCCCC1CCCC(CCP(C)(=O)O)N1 10.1016/j.bmcl.2004.07.049
CHEMBL187692 73944 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 373 15 2 2 6.5 CCCCCCCCCCCCCC1CCCC(CCP(C)(=O)O)N1 10.1016/j.bmcl.2004.07.049
11224984 15489 23 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting
ChEMBL 460 8 2 6 4.3 CCC/N=C1\S/C(=C\c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C 10.1021/jm100181s
CHEMBL1095833 15489 23 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting
ChEMBL 460 8 2 6 4.3 CCC/N=C1\S/C(=C\c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C 10.1021/jm100181s
10883396 10421 45 None - 4 Human 8.6 pIC50 = 8.6 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2008.11.072
5283560 10421 45 None - 4 Human 8.6 pIC50 = 8.6 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2008.11.072
911 10421 45 None - 4 Human 8.6 pIC50 = 8.6 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2008.11.072
CHEMBL225155 10421 45 None - 4 Human 8.6 pIC50 = 8.6 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2008.11.072
10883396 10421 45 None - 4 Human 8.5 pIC50 = 8.5 Binding
Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm100181s
5283560 10421 45 None - 4 Human 8.5 pIC50 = 8.5 Binding
Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm100181s
911 10421 45 None - 4 Human 8.5 pIC50 = 8.5 Binding
Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm100181s
CHEMBL225155 10421 45 None - 4 Human 8.5 pIC50 = 8.5 Binding
Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm100181s
44344194 18688 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 321 16 3 2 4.5 CCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL118265 18688 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 321 16 3 2 4.5 CCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
44394220 73777 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 375 15 3 2 5.8 CCCCCCCCCCCCCCNC1CCCC(P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
CHEMBL186921 73777 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 375 15 3 2 5.8 CCCCCCCCCCCCCCNC1CCCC(P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
10271422 16709 1 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 385 14 4 3 3.8 CCCCCCCCc1ccc(CCC(N)(CO)CCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL114584 16709 1 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 385 14 4 3 3.8 CCCCCCCCc1ccc(CCC(N)(CO)CCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
44412353 173007 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 435 6 2 5 5.5 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc(C5CCCC5)c(F)c4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
CHEMBL426688 173007 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 435 6 2 5 5.5 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc(C5CCCC5)c(F)c4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
10883396 10421 45 None - 4 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2004.02.106
5283560 10421 45 None - 4 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2004.02.106
911 10421 45 None - 4 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2004.02.106
CHEMBL225155 10421 45 None - 4 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1016/j.bmcl.2004.02.106
9885762 16506 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CCC(N)CC(O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL113344 16506 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CCC(N)CC(O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
44344404 18133 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 349 18 3 2 5.2 CCCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL117973 18133 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 349 18 3 2 5.2 CCCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
44413482 172817 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 445 7 2 5 5.0 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(CCC(F)(F)F)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
CHEMBL425602 172817 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 445 7 2 5 5.0 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(CCC(F)(F)F)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
44344413 117322 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.3 CCCCCCCCc1ccc(CCNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL325193 117322 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.3 CCCCCCCCc1ccc(CCNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
44565715 187222 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 498 12 4 5 4.5 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
CHEMBL475253 187222 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 498 12 4 5 4.5 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
10172338 117324 3 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 13 3 2 4.4 CCCCCCCCc1ccc(CCC(N)CCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL325198 117324 3 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 13 3 2 4.4 CCCCCCCCc1ccc(CCC(N)CCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
10251062 77412 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 411 6 1 5 4.6 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(-c5ccccc5)cc4)n3)cc2)C1 10.1021/jm0503244
CHEMBL195025 77412 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 411 6 1 5 4.6 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(-c5ccccc5)cc4)n3)cc2)C1 10.1021/jm0503244
10172338 117324 3 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 355 13 3 2 4.4 CCCCCCCCc1ccc(CCC(N)CCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL325198 117324 3 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 355 13 3 2 4.4 CCCCCCCCc1ccc(CCC(N)CCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
11466640 91865 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 525 7 1 4 6.3 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(Br)c2)C1 10.1021/jm0492507
CHEMBL224599 91865 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 525 7 1 4 6.3 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(Br)c2)C1 10.1021/jm0492507
9796603 171100 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 307 14 3 2 4.2 CCCCCCCCCCCCC(N)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL421234 171100 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 307 14 3 2 4.2 CCCCCCCCCCCCC(N)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
10215259 91882 5 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 331 11 1 2 4.9 CCCCCCCCCc1ccc(CN2CCC(C(=O)O)C2)cc1 10.1021/jm0492507
CHEMBL224703 91882 5 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 331 11 1 2 4.9 CCCCCCCCCc1ccc(CN2CCC(C(=O)O)C2)cc1 10.1021/jm0492507
11725751 19619 5 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.6 CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL118860 19619 5 None - 0 Human 7.6 pIC50 = 7.6 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.6 CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
44565716 186522 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 493 10 4 5 4.6 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 10.1016/j.bmcl.2009.02.073
CHEMBL474418 186522 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 493 10 4 5 4.6 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 10.1016/j.bmcl.2009.02.073
11725751 19619 5 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 355 14 3 2 4.6 CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.07.049
CHEMBL118860 19619 5 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 355 14 3 2 4.6 CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.07.049
44413274 145489 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 447 6 2 4 5.7 O=C(O)C1CNC(c2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1016/j.bmcl.2006.03.090
CHEMBL377968 145489 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 447 6 2 4 5.7 O=C(O)C1CNC(c2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1016/j.bmcl.2006.03.090
11248292 150284 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 465 7 1 4 5.7 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(F)c2)C1 10.1021/jm0492507
CHEMBL389880 150284 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 465 7 1 4 5.7 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(F)c2)C1 10.1021/jm0492507
10384596 16908 2 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@@H](N)C[C@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL115713 16908 2 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@@H](N)C[C@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
10310952 91896 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 477 8 1 5 5.5 COc1cc(CN2CC(C(=O)O)C2)ccc1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 10.1021/jm0492507
CHEMBL224800 91896 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 477 8 1 5 5.5 COc1cc(CN2CC(C(=O)O)C2)ccc1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 10.1021/jm0492507
46885796 15183 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 538 10 4 5 4.8 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)c(C(F)(F)F)c1 10.1016/j.bmcl.2010.02.098
CHEMBL1093429 15183 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 538 10 4 5 4.8 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)c(C(F)(F)F)c1 10.1016/j.bmcl.2010.02.098
44591250 196533 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 420 13 4 5 3.3 CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)cc1F 10.1016/j.bmcl.2008.11.072
CHEMBL515921 196533 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 420 13 4 5 3.3 CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)cc1F 10.1016/j.bmcl.2008.11.072
44565597 186066 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 436 12 4 5 3.2 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCCc2ccccc2)cc1 10.1016/j.bmcl.2009.02.073
CHEMBL473156 186066 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 436 12 4 5 3.2 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCCc2ccccc2)cc1 10.1016/j.bmcl.2009.02.073
44412232 173099 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 391 6 2 5 4.5 CC(C)Cc1ccc(-c2nc(-c3ccc([C@@H]4CC[C@@H](C(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
CHEMBL427221 173099 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 391 6 2 5 4.5 CC(C)Cc1ccc(-c2nc(-c3ccc([C@@H]4CC[C@@H](C(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
44394191 73083 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 381 12 3 2 5.3 CCCCCCCCCc1ccc(C2CCC(CCP(=O)(O)O)N2)cc1 10.1016/j.bmcl.2004.07.049
CHEMBL184879 73083 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 381 12 3 2 5.3 CCCCCCCCCc1ccc(C2CCC(CCP(=O)(O)O)N2)cc1 10.1016/j.bmcl.2004.07.049
44394212 73944 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 373 15 2 2 6.5 CCCCCCCCCCCCCC1CCCC(CCP(C)(=O)O)N1 10.1016/j.bmcl.2004.07.049
CHEMBL187692 73944 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 373 15 2 2 6.5 CCCCCCCCCCCCCC1CCCC(CCP(C)(=O)O)N1 10.1016/j.bmcl.2004.07.049
44413349 84414 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 453 6 2 5 5.4 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
CHEMBL208838 84414 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 453 6 2 5 5.4 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
44394273 71352 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 395 12 3 2 5.6 CCCCCCCCCc1ccc(CN[C@H]2CCC[C@H](P(=O)(O)O)C2)cc1 10.1016/j.bmcl.2004.07.049
CHEMBL181597 71352 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 395 12 3 2 5.6 CCCCCCCCCc1ccc(CN[C@H]2CCC[C@H](P(=O)(O)O)C2)cc1 10.1016/j.bmcl.2004.07.049
10174181 18041 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity towards human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 479 16 3 4 5.2 CCCCCCCCCOc1c(Br)cc(CNCCCP(=O)(O)O)cc1OC 10.1016/j.bmcl.2004.04.070
CHEMBL117910 18041 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity towards human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 479 16 3 4 5.2 CCCCCCCCCOc1c(Br)cc(CNCCCP(=O)(O)O)cc1OC 10.1016/j.bmcl.2004.04.070
10883396 10421 45 None - 4 Human 7.5 pIC50 = 7.5 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm0492507
5283560 10421 45 None - 4 Human 7.5 pIC50 = 7.5 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm0492507
911 10421 45 None - 4 Human 7.5 pIC50 = 7.5 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm0492507
CHEMBL225155 10421 45 None - 4 Human 7.5 pIC50 = 7.5 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 379 17 4 4 4.0 CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O 10.1021/jm0492507
11168252 91859 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 515 7 1 4 6.5 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(C(F)(F)F)c2)C1 10.1021/jm0492507
CHEMBL224549 91859 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 515 7 1 4 6.5 O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(C(F)(F)F)c2)C1 10.1021/jm0492507
44412416 84972 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 431 6 2 5 5.7 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
CHEMBL210520 84972 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 431 6 2 5 5.7 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
10249887 77703 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 5 1 5 4.2 CC(C)(C)c1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
CHEMBL195141 77703 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 5 1 5 4.2 CC(C)(C)c1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
10249979 78421 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 393 7 1 6 3.7 CC(C)Oc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
CHEMBL196357 78421 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 393 7 1 6 3.7 CC(C)Oc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
44413415 145468 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 461 7 2 4 6.1 O=C(O)CC1CNC(c2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1016/j.bmcl.2006.03.090
CHEMBL377855 145468 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 461 7 2 4 6.1 O=C(O)CC1CNC(c2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1016/j.bmcl.2006.03.090
44591249 187415 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 402 13 4 5 3.2 CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)cc1 10.1016/j.bmcl.2008.11.072
CHEMBL475495 187415 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 402 13 4 5 3.2 CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)cc1 10.1016/j.bmcl.2008.11.072
11540052 187346 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 470 10 4 5 3.7 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
CHEMBL475405 187346 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 470 10 4 5 3.7 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
25008420 15236 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 547 9 4 5 5.6 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)c(C(F)(F)F)c2)c[nH]1 10.1016/j.bmcl.2010.02.098
CHEMBL1093823 15236 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 547 9 4 5 5.6 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)c(C(F)(F)F)c2)c[nH]1 10.1016/j.bmcl.2010.02.098
44565717 196309 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 479 9 4 5 4.6 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 10.1016/j.bmcl.2010.02.098
CHEMBL514170 196309 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 479 9 4 5 4.6 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 10.1016/j.bmcl.2010.02.098
44565717 196309 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 479 9 4 5 4.6 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 10.1016/j.bmcl.2009.02.073
CHEMBL514170 196309 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 479 9 4 5 4.6 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 10.1016/j.bmcl.2009.02.073
11725751 19619 5 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.6 CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL118860 19619 5 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.6 CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
9979368 78481 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 417 6 1 5 5.0 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)C1 10.1021/jm0503244
CHEMBL196534 78481 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 417 6 1 5 5.0 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)C1 10.1021/jm0503244
10193676 20511 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 2 2 5.2 CCCCCCCCCc1ccc(CNCCC(F)(F)C(=O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL119516 20511 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 2 2 5.2 CCCCCCCCCc1ccc(CNCCC(F)(F)C(=O)O)cc1 10.1016/j.bmcl.2004.04.069
11743459 147569 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 431 7 1 5 4.4 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(CCC(F)(F)F)cc4)n3)cc2)C1 10.1021/jm0503244
CHEMBL381872 147569 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 431 7 1 5 4.4 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(CCC(F)(F)F)cc4)n3)cc2)C1 10.1021/jm0503244
11502026 78229 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 5 1 5 4.2 CC(C)(C)c1ccc(-c2nnc(-c3ccc(CN4CC(C(=O)O)C4)cc3)o2)cc1 10.1021/jm0503244
CHEMBL196149 78229 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 5 1 5 4.2 CC(C)(C)c1ccc(-c2nnc(-c3ccc(CN4CC(C(=O)O)C4)cc3)o2)cc1 10.1021/jm0503244
10287034 72957 3 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 367 11 2 2 4.7 CCCCCCCCCc1ccc(CN2CCC(P(=O)(O)O)C2)cc1 10.1021/jm0492507
CHEMBL184349 72957 3 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 367 11 2 2 4.7 CCCCCCCCCc1ccc(CN2CCC(P(=O)(O)O)C2)cc1 10.1021/jm0492507
10408874 79265 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 403 6 1 5 4.6 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCCC5)cc4)n3)cc2)C1 10.1021/jm0503244
CHEMBL198976 79265 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 403 6 1 5 4.6 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCCC5)cc4)n3)cc2)C1 10.1021/jm0503244
44565714 186076 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 484 11 4 5 4.1 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
CHEMBL473238 186076 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 484 11 4 5 4.1 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
44341466 16786 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@H](N)C[C@@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL114976 16786 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@H](N)C[C@@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
11653967 77349 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 389 6 1 5 4.2 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCC5)cc4)n3)cc2)C1 10.1021/jm0503244
CHEMBL194898 77349 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 389 6 1 5 4.2 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCC5)cc4)n3)cc2)C1 10.1021/jm0503244
44412294 145427 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 419 8 2 5 5.3 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4CC[C@@H](CCC(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
CHEMBL377637 145427 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 419 8 2 5 5.3 CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4CC[C@@H](CCC(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
10149721 91872 5 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 317 11 1 2 4.5 CCCCCCCCCc1ccc(CN2CC(C(=O)O)C2)cc1 10.1021/jm0492507
CHEMBL224623 91872 5 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 317 11 1 2 4.5 CCCCCCCCCc1ccc(CN2CC(C(=O)O)C2)cc1 10.1021/jm0492507
44412165 84536 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 453 6 2 5 5.6 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
CHEMBL209076 84536 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 453 6 2 5 5.6 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
10286857 174883 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 353 14 2 2 5.4 CCCCCCCCCc1ccc(CNCCCP(C)(=O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL432809 174883 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 353 14 2 2 5.4 CCCCCCCCCc1ccc(CNCCCP(C)(=O)O)cc1 10.1016/j.bmcl.2004.04.069
11683935 186120 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 456 9 4 5 3.7 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
CHEMBL473563 186120 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 456 9 4 5 3.7 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCc2ccc(-c3ccccc3)cc2)cc1 10.1016/j.bmcl.2009.02.073
46885798 14803 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 561 10 4 5 5.7 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCc3ccc(-c4ccccc4)cc3)c(C(F)(F)F)c2)c[nH]1 10.1016/j.bmcl.2010.02.098
CHEMBL1090829 14803 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
ChEMBL 561 10 4 5 5.7 C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCc3ccc(-c4ccccc4)cc3)c(C(F)(F)F)c2)c[nH]1 10.1016/j.bmcl.2010.02.098
10125882 172363 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 337 14 2 2 4.9 CCCCCCCCCc1ccc(CNCC(F)CC(=O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL424254 172363 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 337 14 2 2 4.9 CCCCCCCCCc1ccc(CNCC(F)CC(=O)O)cc1 10.1016/j.bmcl.2004.04.069
44412415 84953 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 419 8 2 5 5.3 CC(C)Cc1ccc(-c2nc(-c3ccc([C@@H]4CC[C@@H](CCC(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
CHEMBL210468 84953 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 419 8 2 5 5.3 CC(C)Cc1ccc(-c2nc(-c3ccc([C@@H]4CC[C@@H](CCC(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
44394248 73023 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 361 15 3 2 5.4 CCCCCCCCCCCCCCNC1CCC(P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
CHEMBL184591 73023 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 361 15 3 2 5.4 CCCCCCCCCCCCCCNC1CCC(P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
11696807 132735 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 5 1 5 4.2 CC(C)(C)c1ccc(-c2noc(-c3ccc(CN4CC(C(=O)O)C4)cc3)n2)cc1 10.1021/jm0503244
CHEMBL364899 132735 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 5 1 5 4.2 CC(C)(C)c1ccc(-c2noc(-c3ccc(CN4CC(C(=O)O)C4)cc3)n2)cc1 10.1021/jm0503244
11752659 172923 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 515 7 1 4 6.8 O=C(O)C1CN(Cc2cc(Cl)c(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(Cl)c2)C1 10.1021/jm0492507
CHEMBL426191 172923 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 515 7 1 4 6.8 O=C(O)C1CN(Cc2cc(Cl)c(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(Cl)c2)C1 10.1021/jm0492507
44344210 20579 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 307 15 3 2 4.1 CCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL119562 20579 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 307 15 3 2 4.1 CCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
11604577 79100 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 439 6 1 5 4.8 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc([C@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 10.1021/jm0503244
CHEMBL198415 79100 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 439 6 1 5 4.8 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc([C@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 10.1021/jm0503244
10430549 7834 39 None - 0 Human 7.2 pIC50 = 7.2 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 7 1 5 4.1 CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C 10.1021/jm0503244
2929 7834 39 None - 0 Human 7.2 pIC50 = 7.2 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 7 1 5 4.1 CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C 10.1021/jm0503244
CHEMBL194419 7834 39 None - 0 Human 7.2 pIC50 = 7.2 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 7 1 5 4.1 CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C 10.1021/jm0503244
10045980 76615 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 8 1 5 4.3 CCCCc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
CHEMBL193789 76615 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 391 8 1 5 4.3 CCCCc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
10430549 7834 39 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 391 7 1 5 4.1 CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C 10.1016/j.bmcl.2006.03.090
2929 7834 39 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 391 7 1 5 4.1 CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C 10.1016/j.bmcl.2006.03.090
CHEMBL194419 7834 39 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 391 7 1 5 4.1 CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C 10.1016/j.bmcl.2006.03.090
44412282 85071 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 405 7 2 5 4.9 CC(C)Cc1ccc(-c2nc(-c3ccc([C@@H]4CC[C@@H](CC(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
CHEMBL210785 85071 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 405 7 2 5 4.9 CC(C)Cc1ccc(-c2nc(-c3ccc([C@@H]4CC[C@@H](CC(=O)O)N4)cc3)no2)cc1 10.1016/j.bmcl.2006.03.038
44412165 84536 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 453 6 2 5 5.6 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
CHEMBL209076 84536 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 453 6 2 5 5.6 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
44412364 84878 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 453 6 2 5 5.6 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
CHEMBL210257 84878 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [33P]S1P from S1P4 expressed in CHO cellsDisplacement of [33P]S1P from S1P4 expressed in CHO cells
ChEMBL 453 6 2 5 5.6 O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 10.1016/j.bmcl.2006.03.038
10363915 141971 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 405 7 1 5 4.6 CCC(C)(C)c1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
CHEMBL372066 141971 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 405 7 1 5 4.6 CCC(C)(C)c1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
10125861 19972 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 335 16 3 2 5.0 CCCCCCCCCCCCCCC(N)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL119110 19972 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 335 16 3 2 5.0 CCCCCCCCCCCCCCC(N)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
44394220 73777 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 375 15 3 2 5.8 CCCCCCCCCCCCCCNC1CCCC(P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
CHEMBL186921 73777 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 375 15 3 2 5.8 CCCCCCCCCCCCCCNC1CCCC(P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
10195325 91895 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 461 7 1 4 5.9 O=C(O)C1CCN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1021/jm0492507
CHEMBL224799 91895 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 461 7 1 4 5.9 O=C(O)C1CCN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 10.1021/jm0492507
44565622 186119 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 428 11 4 5 3.6 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCC2CCCCC2)cc1 10.1016/j.bmcl.2009.02.073
CHEMBL473562 186119 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorDisplacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
ChEMBL 428 11 4 5 3.6 C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCC2CCCCC2)cc1 10.1016/j.bmcl.2009.02.073
44394191 73083 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 381 12 3 2 5.3 CCCCCCCCCc1ccc(C2CCC(CCP(=O)(O)O)N2)cc1 10.1016/j.bmcl.2004.07.049
CHEMBL184879 73083 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 381 12 3 2 5.3 CCCCCCCCCc1ccc(C2CCC(CCP(=O)(O)O)N2)cc1 10.1016/j.bmcl.2004.07.049
10127776 17825 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 465 15 3 4 4.9 CCCCCCCCOc1c(Br)cc(CNCCCP(=O)(O)O)cc1OC 10.1021/jm0492507
CHEMBL117723 17825 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
ChEMBL 465 15 3 4 4.9 CCCCCCCCOc1c(Br)cc(CNCCCP(=O)(O)O)cc1OC 10.1021/jm0492507
21455530 16914 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 363 19 3 2 5.6 CCCCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL115738 16914 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 363 19 3 2 5.6 CCCCCCCCCCCCCCCCNCCCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
44413349 84414 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 453 6 2 5 5.4 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
CHEMBL208838 84414 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [33P]S1P from human S1P4 receptor expressed in CHO cellsDisplacement of [33P]S1P from human S1P4 receptor expressed in CHO cells
ChEMBL 453 6 2 5 5.4 O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 10.1016/j.bmcl.2006.03.090
44344412 20126 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.3 CCCCCCCc1ccc(CCCNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL119233 20126 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.3 CCCCCCCc1ccc(CCCNCCCP(=O)(O)O)cc1 10.1016/j.bmcl.2004.04.069
10287034 72957 3 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 367 11 2 2 4.7 CCCCCCCCCc1ccc(CN2CCC(P(=O)(O)O)C2)cc1 10.1016/j.bmcl.2004.07.049
CHEMBL184349 72957 3 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 367 11 2 2 4.7 CCCCCCCCCc1ccc(CN2CCC(P(=O)(O)O)C2)cc1 10.1016/j.bmcl.2004.07.049
44394169 73457 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 375 16 2 2 5.7 CCCCCCCCCCCCCCN1CCCC1CCP(=O)(O)O 10.1016/j.bmcl.2004.07.049
CHEMBL185447 73457 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 375 16 2 2 5.7 CCCCCCCCCCCCCCN1CCCC1CCP(=O)(O)O 10.1016/j.bmcl.2004.07.049
44341291 16909 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@H](N)C[C@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
CHEMBL115714 16909 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 371 13 4 3 3.7 CCCCCCCCc1ccc(CC[C@H](N)C[C@H](O)P(=O)(O)O)cc1 10.1016/j.bmcl.2004.02.106
11575787 77407 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 439 6 1 5 4.8 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 10.1021/jm0503244
CHEMBL195014 77407 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 439 6 1 5 4.8 O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 10.1021/jm0503244
10476387 134293 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 405 6 1 5 4.5 CC(C)(C)Cc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
CHEMBL366181 134293 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cellsConcentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 4 expressed in CHO cells
ChEMBL 405 6 1 5 4.5 CC(C)(C)Cc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 10.1021/jm0503244
44344360 17018 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 339 14 3 3 4.8 CCCCCCCCCc1ccc(CNCCCP(O)O)cc1 10.1016/j.bmcl.2004.04.069
CHEMBL1160958 17018 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 339 14 3 3 4.8 CCCCCCCCCc1ccc(CNCCCP(O)O)cc1 10.1016/j.bmcl.2004.04.069
44394153 72930 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 363 14 3 3 4.3 CCCCCCCCCCCCCCN1CCC(O)(P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
CHEMBL184237 72930 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesInhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
ChEMBL 363 14 3 3 4.3 CCCCCCCCCCCCCCN1CCC(O)(P(=O)(O)O)C1 10.1016/j.bmcl.2004.07.049
44344456 17415 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.6 NC(CCCCCCCCCCc1ccccc1)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
CHEMBL117031 17415 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandBinding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
ChEMBL 355 14 3 2 4.6 NC(CCCCCCCCCCc1ccccc1)CCP(=O)(O)O 10.1016/j.bmcl.2004.04.069
11502996 165506 42 None -50 4 Human 7.5 pKi = 7.5 Binding
Displacement of [33P]-S1P from human S1P4 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodDisplacement of [33P]-S1P from human S1P4 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting method
ChEMBL 435 9 1 4 5.0 CCCc1ccc(COc2ccc3c(c2)CCC(CN2CC(C(=O)O)C2)=C3C)c(OC)c1 10.1021/acs.jmedchem.7b00785
CHEMBL4093489 165506 42 None -50 4 Human 7.5 pKi = 7.5 Binding
Displacement of [33P]-S1P from human S1P4 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodDisplacement of [33P]-S1P from human S1P4 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting method
ChEMBL 435 9 1 4 5.0 CCCc1ccc(COc2ccc3c(c2)CCC(CN2CC(C(=O)O)C2)=C3C)c(OC)c1 10.1021/acs.jmedchem.7b00785
11363176 9923 47 None - 0 Human 5.7 pIC50 = 5.7 Binding
In a radioligand binding assay using membranes from CHO cells expressing human S1P<sub>4</sub>In a radioligand binding assay using membranes from CHO cells expressing human S1P<sub>4</sub>
Guide to Pharmacology 460 8 2 6 4.3 CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C 20446681
5446 9923 47 None - 0 Human 5.7 pIC50 = 5.7 Binding
In a radioligand binding assay using membranes from CHO cells expressing human S1P<sub>4</sub>In a radioligand binding assay using membranes from CHO cells expressing human S1P<sub>4</sub>
Guide to Pharmacology 460 8 2 6 4.3 CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C 20446681
9320 9923 47 None - 0 Human 5.7 pIC50 = 5.7 Binding
In a radioligand binding assay using membranes from CHO cells expressing human S1P<sub>4</sub>In a radioligand binding assay using membranes from CHO cells expressing human S1P<sub>4</sub>
Guide to Pharmacology 460 8 2 6 4.3 CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C 20446681
CHEMBL1096146 9923 47 None - 0 Human 5.7 pIC50 = 5.7 Binding
In a radioligand binding assay using membranes from CHO cells expressing human S1P<sub>4</sub>In a radioligand binding assay using membranes from CHO cells expressing human S1P<sub>4</sub>
Guide to Pharmacology 460 8 2 6 4.3 CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C 20446681
DB12016 9923 47 None - 0 Human 5.7 pIC50 = 5.7 Binding
In a radioligand binding assay using membranes from CHO cells expressing human S1P<sub>4</sub>In a radioligand binding assay using membranes from CHO cells expressing human S1P<sub>4</sub>
Guide to Pharmacology 460 8 2 6 4.3 CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C 20446681
6992 10781 0 None -7 5 Human 7.8 pKd = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 369 11 3 3 4.3 CCCCCCCCc1cccc(c1)C1CC(C1)(N)COP(=O)(O)O 21632869
73755254 10781 0 None -7 5 Human 7.8 pKd = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 369 11 3 3 4.3 CCCCCCCCc1cccc(c1)C1CC(C1)(N)COP(=O)(O)O 21632869