Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 2924 | 1640 | None | 38 | Human | Functional | pEC50 | = | 10.1 | 10.1 | -6 | 7 | Agonist activity at human S1P4 receptor by GTPgammaS binding assayAgonist activity at human S1P4 receptor by GTPgammaS binding assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acsmedchemlett.5b00448 | ||
| 44398069 | 1640 | None | 38 | Human | Functional | pEC50 | = | 10.1 | 10.1 | -6 | 7 | Agonist activity at human S1P4 receptor by GTPgammaS binding assayAgonist activity at human S1P4 receptor by GTPgammaS binding assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acsmedchemlett.5b00448 | ||
| 9908268 | 1640 | None | 38 | Human | Functional | pEC50 | = | 10.1 | 10.1 | -6 | 7 | Agonist activity at human S1P4 receptor by GTPgammaS binding assayAgonist activity at human S1P4 receptor by GTPgammaS binding assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acsmedchemlett.5b00448 | ||
| CHEMBL114606 | 1640 | None | 38 | Human | Functional | pEC50 | = | 10.1 | 10.1 | -6 | 7 | Agonist activity at human S1P4 receptor by GTPgammaS binding assayAgonist activity at human S1P4 receptor by GTPgammaS binding assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acsmedchemlett.5b00448 | ||
| 11452022 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -26 | 6 | Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/jm050242f | ||
| 6996 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -26 | 6 | Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/jm050242f | ||
| CHEMBL366208 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -26 | 6 | Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/jm050242f | ||
| 11222939 | 67596 | None | 8 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -12 | 4 | Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2010.01.118 | ||
| 44438254 | 67596 | None | 8 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -12 | 4 | Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2010.01.118 | ||
| CHEMBL190006 | 67596 | None | 8 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -12 | 4 | Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2010.01.118 | ||
| 10904818 | 303 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -1 | 4 | Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay |
ChEMBL | 373 | 13 | 3 | 4 | 3.8 | CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C | 10.1016/j.bmcl.2005.09.038 | ||
| 2937 | 303 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -1 | 4 | Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay |
ChEMBL | 373 | 13 | 3 | 4 | 3.8 | CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C | 10.1016/j.bmcl.2005.09.038 | ||
| CHEMBL382739 | 303 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -1 | 4 | Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay |
ChEMBL | 373 | 13 | 3 | 4 | 3.8 | CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C | 10.1016/j.bmcl.2005.09.038 | ||
| 44406004 | 72740 | None | 10 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -7 | 4 | Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay |
ChEMBL | 337 | 14 | 4 | 4 | 2.9 | CCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(=O)(O)O | 10.1016/j.bmcl.2005.09.038 | ||
| CHEMBL199791 | 72740 | None | 10 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -7 | 4 | Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assayBinding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay |
ChEMBL | 337 | 14 | 4 | 4 | 2.9 | CCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(=O)(O)O | 10.1016/j.bmcl.2005.09.038 | ||
| 11452022 | 3596 | None | 37 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -26 | 6 | Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.8b01695 | ||
| 6996 | 3596 | None | 37 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -26 | 6 | Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.8b01695 | ||
| CHEMBL366208 | 3596 | None | 37 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -26 | 6 | Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.8b01695 | ||
| 2924 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -6 | 7 | Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.0c01109 | ||
| 44398069 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -6 | 7 | Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.0c01109 | ||
| 9908268 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -6 | 7 | Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.0c01109 | ||
| CHEMBL114606 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -6 | 7 | Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.0c01109 | ||
| 11177439 | 67914 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 239 | 2 | Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay |
ChEMBL | 413 | 7 | 4 | 3 | 3.6 | N[C@H](CNC(=O)c1cc2c(-c3ccccc3Cc3ccccc3)cccc2[nH]1)C(=O)O | 10.1016/j.bmcl.2011.09.049 | ||
| CHEMBL1910654 | 67914 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | 239 | 2 | Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay |
ChEMBL | 413 | 7 | 4 | 3 | 3.6 | N[C@H](CNC(=O)c1cc2c(-c3ccccc3Cc3ccccc3)cccc2[nH]1)C(=O)O | 10.1016/j.bmcl.2011.09.049 | ||
| 118877584 | 182559 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | -15 | 3 | Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 411 | 9 | 3 | 4 | 3.7 | CCOCCC[C@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acs.jmedchem.0c01109 | ||
| CHEMBL4786296 | 182559 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | -15 | 3 | Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 411 | 9 | 3 | 4 | 3.7 | CCOCCC[C@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acs.jmedchem.0c01109 | ||
| 78321974 | 140401 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -21 | 3 | Agonist activity at human S1P4 receptor by GTPgammaS binding assayAgonist activity at human S1P4 receptor by GTPgammaS binding assay |
ChEMBL | 409 | 9 | 3 | 3 | 4.8 | CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acsmedchemlett.5b00448 | ||
| CHEMBL3806205 | 140401 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -21 | 3 | Agonist activity at human S1P4 receptor by GTPgammaS binding assayAgonist activity at human S1P4 receptor by GTPgammaS binding assay |
ChEMBL | 409 | 9 | 3 | 3 | 4.8 | CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acsmedchemlett.5b00448 | ||
| 78321974 | 140401 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -21 | 3 | Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay |
ChEMBL | 409 | 9 | 3 | 3 | 4.8 | CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acs.jmedchem.8b01695 | ||
| CHEMBL3806205 | 140401 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -21 | 3 | Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay |
ChEMBL | 409 | 9 | 3 | 3 | 4.8 | CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acs.jmedchem.8b01695 | ||
| 78321974 | 140401 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -21 | 3 | Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 409 | 9 | 3 | 3 | 4.8 | CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acs.jmedchem.0c01109 | ||
| CHEMBL3806205 | 140401 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -21 | 3 | Agonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 409 | 9 | 3 | 3 | 4.8 | CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acs.jmedchem.0c01109 | ||
| 46224767 | 201754 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -14 | 4 | Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay |
ChEMBL | 293 | 2 | 0 | 4 | 3.2 | Cc1nn(C(=O)/C=C/c2ccncc2)c2c1[C@H]1[C@@H](C2)C1(C)C | 10.1016/j.bmcl.2009.11.045 | ||
| CHEMBL590383 | 201754 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -14 | 4 | Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay |
ChEMBL | 293 | 2 | 0 | 4 | 3.2 | Cc1nn(C(=O)/C=C/c2ccncc2)c2c1[C@H]1[C@@H](C2)C1(C)C | 10.1016/j.bmcl.2009.11.045 | ||
| 46224768 | 201755 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -5 | 3 | Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay |
ChEMBL | 293 | 2 | 0 | 4 | 3.2 | Cc1nn(C(=O)/C=C/c2cccnc2)c2c1[C@H]1[C@@H](C2)C1(C)C | 10.1016/j.bmcl.2009.11.045 | ||
| CHEMBL590384 | 201755 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | -5 | 3 | Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay |
ChEMBL | 293 | 2 | 0 | 4 | 3.2 | Cc1nn(C(=O)/C=C/c2cccnc2)c2c1[C@H]1[C@@H](C2)C1(C)C | 10.1016/j.bmcl.2009.11.045 | ||
| 136042187 | 67941 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay |
ChEMBL | 347 | 2 | 1 | 4 | 3.6 | C/N=C1/NC(=O)/C(=C/c2cc(C)n(-c3ccc(F)cc3F)c2C)S1 | 10.1016/j.bmcl.2011.09.049 | ||
| CHEMBL1910799 | 67941 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay |
ChEMBL | 347 | 2 | 1 | 4 | 3.6 | C/N=C1/NC(=O)/C(=C/c2cc(C)n(-c3ccc(F)cc3F)c2C)S1 | 10.1016/j.bmcl.2011.09.049 | ||
| 57395471 | 67942 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 7 | 3 | Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay |
ChEMBL | 389 | 4 | 0 | 4 | 4.7 | CC/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3F)c2C)C(=O)N1CC | 10.1016/j.bmcl.2011.09.049 | ||
| CHEMBL1910800 | 67942 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | 7 | 3 | Agonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assayAgonist activity at S1P4 receptor in human U2OS cells expressing VP16-GAL4 transcriptional factor and beta-arrestin/TEV protease fusion protein assessed as migration of VP16-GAL4 into nucleus by FRET based beta lactamase reporter gene assay |
ChEMBL | 389 | 4 | 0 | 4 | 4.7 | CC/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3F)c2C)C(=O)N1CC | 10.1016/j.bmcl.2011.09.049 | ||
| 45377662 | 84151 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -354 | 4 | Agonist activity at S1P4 receptorAgonist activity at S1P4 receptor |
ChEMBL | 468 | 9 | 1 | 6 | 4.3 | CCCCN(C(=O)c1ccccc1F)c1nnc(-c2ccc(CN3CC(C(=O)O)C3)cc2)s1 | 10.1016/j.bmcl.2012.09.110 | ||
| CHEMBL2207778 | 84151 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -354 | 4 | Agonist activity at S1P4 receptorAgonist activity at S1P4 receptor |
ChEMBL | 468 | 9 | 1 | 6 | 4.3 | CCCCN(C(=O)c1ccccc1F)c1nnc(-c2ccc(CN3CC(C(=O)O)C3)cc2)s1 | 10.1016/j.bmcl.2012.09.110 | ||
| 11224984 | 8719 | None | 24 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -218 | 4 | Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assayAgonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay |
ChEMBL | 460 | 8 | 2 | 6 | 4.3 | CCC/N=C1\S/C(=C\c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C | 10.1021/jm100181s | ||
| CHEMBL1095833 | 8719 | None | 24 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -218 | 4 | Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assayAgonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay |
ChEMBL | 460 | 8 | 2 | 6 | 4.3 | CCC/N=C1\S/C(=C\c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C | 10.1021/jm100181s | ||
| 4097071 | 35906 | None | 9 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -1 | 2 | PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)] |
ChEMBL | 400 | 5 | 0 | 5 | 5.1 | COc1cccc(C2CN(c3ccc(F)cc3F)N=C2c2cccs2)c1OC | nan | ||
| CHEMBL1442207 | 35906 | None | 9 | Human | Functional | pEC50 | = | 5.0 | 5.0 | -1 | 2 | PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)] |
ChEMBL | 400 | 5 | 0 | 5 | 5.1 | COc1cccc(C2CN(c3ccc(F)cc3F)N=C2c2cccs2)c1OC | nan | ||
| 46224715 | 201714 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -10 | 4 | Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay |
ChEMBL | 371 | 3 | 1 | 5 | 2.5 | Cc1nn(C(=O)/C=C/c2cccc(S(N)(=O)=O)c2)c2c1[C@H]1[C@@H](C2)C1(C)C | 10.1016/j.bmcl.2009.11.045 | ||
| CHEMBL590135 | 201714 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -10 | 4 | Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assayAgonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay |
ChEMBL | 371 | 3 | 1 | 5 | 2.5 | Cc1nn(C(=O)/C=C/c2cccc(S(N)(=O)=O)c2)c2c1[C@H]1[C@@H](C2)C1(C)C | 10.1016/j.bmcl.2009.11.045 | ||
| 135656247 | 72631 | None | 5 | Human | Functional | pEC50 | = | 4.9 | 4.9 | 7 | 2 | PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)] |
ChEMBL | 277 | 2 | 3 | 5 | 1.1 | C/C(=N/NC(N)=S)c1cc2ccc(O)cc2oc1=O | nan | ||
| CHEMBL1993778 | 72631 | None | 5 | Human | Functional | pEC50 | = | 4.9 | 4.9 | 7 | 2 | PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)]PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1509 (Primary screen.), 1523 (Confirmation screen in triplicates.)] |
ChEMBL | 277 | 2 | 3 | 5 | 1.1 | C/C(=N/NC(N)=S)c1cc2ccc(O)cc2oc1=O | nan | ||
Showing 1 to 50 of 963 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 107970 | 1639 | None | 56 | Human | Binding | pEC50 | = | 9.5 | 9.5 | - | 0 | Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin) |
ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2013.09.058 | ||
| 107970.0 | 1639 | None | 56 | Human | Binding | pEC50 | = | 9.5 | 9.5 | - | 0 | Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin) |
ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2013.09.058 | ||
| 2407 | 1639 | None | 56 | Human | Binding | pEC50 | = | 9.5 | 9.5 | - | 0 | Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin) |
ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2013.09.058 | ||
| 4167 | 1639 | None | 56 | Human | Binding | pEC50 | = | 9.5 | 9.5 | - | 0 | Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin) |
ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2013.09.058 | ||
| CHEMBL314854 | 1639 | None | 56 | Human | Binding | pEC50 | = | 9.5 | 9.5 | - | 0 | Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin) |
ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2013.09.058 | ||
| DB08868 | 1639 | None | 56 | Human | Binding | pEC50 | = | 9.5 | 9.5 | - | 0 | Agonist activity at S1P4 receptor (unknown origin)Agonist activity at S1P4 receptor (unknown origin) |
ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2013.09.058 | ||
| 49868651 | 171251 | None | 1 | Human | Binding | pEC50 | = | 9.3 | 9.3 | - | 0 | Agonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayAgonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assay |
ChEMBL | 542 | 8 | 2 | 8 | 5.3 | O=C(O)C[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 | 10.1021/acs.jmedchem.6b00373 | ||
| CHEMBL4458575 | 171251 | None | 1 | Human | Binding | pEC50 | = | 9.3 | 9.3 | - | 0 | Agonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayAgonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assay |
ChEMBL | 542 | 8 | 2 | 8 | 5.3 | O=C(O)C[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 | 10.1021/acs.jmedchem.6b00373 | ||
| 50925337 | 170555 | None | 14 | Human | Binding | pEC50 | = | 9.0 | 9.0 | - | 0 | Agonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayAgonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assay |
ChEMBL | 528 | 7 | 2 | 8 | 4.9 | O=C(O)[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 | 10.1021/acs.jmedchem.6b00373 | ||
| CHEMBL4448752 | 170555 | None | 14 | Human | Binding | pEC50 | = | 9.0 | 9.0 | - | 0 | Agonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayAgonist activity at S1P4 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assay |
ChEMBL | 528 | 7 | 2 | 8 | 4.9 | O=C(O)[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 | 10.1021/acs.jmedchem.6b00373 | ||
| 134131598 | 142357 | None | 0 | Human | Binding | pEC50 | = | 6 | 6.0 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 373 | 4 | 1 | 3 | 5.2 | O=C(O)C1CN(Cc2cc3c(-c4ccc5ccccc5c4)cccc3s2)C1 | 10.1016/j.bmcl.2016.11.050 | ||
| CHEMBL3884966 | 142357 | None | 0 | Human | Binding | pEC50 | = | 6 | 6.0 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 373 | 4 | 1 | 3 | 5.2 | O=C(O)C1CN(Cc2cc3c(-c4ccc5ccccc5c4)cccc3s2)C1 | 10.1016/j.bmcl.2016.11.050 | ||
| 134130192 | 142291 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 375 | 6 | 2 | 3 | 5.5 | CC(CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1)C(=O)O | 10.1016/j.bmcl.2016.11.050 | ||
| CHEMBL3884134 | 142291 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 375 | 6 | 2 | 3 | 5.5 | CC(CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1)C(=O)O | 10.1016/j.bmcl.2016.11.050 | ||
| 134131497 | 142234 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 353 | 7 | 2 | 3 | 4.9 | CCc1ccccc1-c1cccc2sc(CNCC(C)C(=O)O)cc12 | 10.1016/j.bmcl.2016.11.050 | ||
| CHEMBL3883549 | 142234 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 353 | 7 | 2 | 3 | 4.9 | CCc1ccccc1-c1cccc2sc(CNCC(C)C(=O)O)cc12 | 10.1016/j.bmcl.2016.11.050 | ||
| 134130884 | 142237 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 389 | 8 | 2 | 3 | 6.1 | O=C(O)CCCCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 | 10.1016/j.bmcl.2016.11.050 | ||
| CHEMBL3883572 | 142237 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 389 | 8 | 2 | 3 | 6.1 | O=C(O)CCCCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 | 10.1016/j.bmcl.2016.11.050 | ||
| 134130150 | 142226 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 376 | 6 | 3 | 4 | 4.2 | NC(CNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1)C(=O)O | 10.1016/j.bmcl.2016.11.050 | ||
| CHEMBL3883471 | 142226 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 376 | 6 | 3 | 4 | 4.2 | NC(CNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1)C(=O)O | 10.1016/j.bmcl.2016.11.050 | ||
| 134131253 | 142380 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 367 | 9 | 2 | 3 | 5.5 | CCc1ccccc1-c1cccc2sc(CNCCCCC(=O)O)cc12 | 10.1016/j.bmcl.2016.11.050 | ||
| CHEMBL3885187 | 142380 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 367 | 9 | 2 | 3 | 5.5 | CCc1ccccc1-c1cccc2sc(CNCCCCC(=O)O)cc12 | 10.1016/j.bmcl.2016.11.050 | ||
| 134130662 | 142361 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 375 | 6 | 2 | 3 | 5.5 | CC(CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1)C(=O)O | 10.1016/j.bmcl.2016.11.050 | ||
| CHEMBL3884995 | 142361 | None | 0 | Human | Binding | pEC50 | = | 6.9 | 6.9 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 375 | 6 | 2 | 3 | 5.5 | CC(CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1)C(=O)O | 10.1016/j.bmcl.2016.11.050 | ||
| 134131209 | 142405 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 401 | 7 | 2 | 3 | 6.4 | CCc1ccccc1-c1cccc2cc(CNc3cccc(CC(=O)O)c3)sc12 | 10.1016/j.bmcl.2016.11.050 | ||
| CHEMBL3885415 | 142405 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 401 | 7 | 2 | 3 | 6.4 | CCc1ccccc1-c1cccc2cc(CNc3cccc(CC(=O)O)c3)sc12 | 10.1016/j.bmcl.2016.11.050 | ||
| 44394289 | 12413 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand |
ChEMBL | 383 | 11 | 4 | 4 | 3.7 | CCCCCCCCc1ccc2[nH]c(C(C)(N)COP(=O)(O)O)nc2c1 | 10.1016/j.bmcl.2004.07.030 | ||
| CHEMBL1185803 | 12413 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand |
ChEMBL | 383 | 11 | 4 | 4 | 3.7 | CCCCCCCCc1ccc2[nH]c(C(C)(N)COP(=O)(O)O)nc2c1 | 10.1016/j.bmcl.2004.07.030 | ||
| CHEMBL433593 | 12413 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand |
ChEMBL | 383 | 11 | 4 | 4 | 3.7 | CCCCCCCCc1ccc2[nH]c(C(C)(N)COP(=O)(O)O)nc2c1 | 10.1016/j.bmcl.2004.07.030 | ||
| 134131399 | 142402 | None | 0 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 339 | 7 | 2 | 3 | 4.8 | Cc1ccccc1-c1cccc2cc(CNCCCC(=O)O)sc12 | 10.1016/j.bmcl.2016.11.050 | ||
| CHEMBL3885401 | 142402 | None | 0 | Human | Binding | pEC50 | = | 4.9 | 4.9 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 339 | 7 | 2 | 3 | 4.8 | Cc1ccccc1-c1cccc2cc(CNCCCC(=O)O)sc12 | 10.1016/j.bmcl.2016.11.050 | ||
| 44342331 | 11420 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 428 | 16 | 4 | 4 | 4.5 | CCCCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | ||
| CHEMBL116953 | 11420 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 428 | 16 | 4 | 4 | 4.5 | CCCCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | ||
| CHEMBL1180214 | 11420 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 428 | 16 | 4 | 4 | 4.5 | CCCCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | ||
| 134131067 | 142272 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 423 | 6 | 2 | 3 | 7.0 | O=C(O)Cc1ccc(NCc2cc3cccc(-c4ccc5ccccc5c4)c3s2)cc1 | 10.1016/j.bmcl.2016.11.050 | ||
| CHEMBL3883991 | 142272 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 423 | 6 | 2 | 3 | 7.0 | O=C(O)Cc1ccc(NCc2cc3cccc(-c4ccc5ccccc5c4)c3s2)cc1 | 10.1016/j.bmcl.2016.11.050 | ||
| 44623998 | 1596 | None | 39 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay |
ChEMBL | 457 | 6 | 2 | 2 | 6.9 | OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 | 10.1021/ml500389m | ||
| 44623998.0 | 1596 | None | 39 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay |
ChEMBL | 457 | 6 | 2 | 2 | 6.9 | OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 | 10.1021/ml500389m | ||
| 9331 | 1596 | None | 39 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay |
ChEMBL | 457 | 6 | 2 | 2 | 6.9 | OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 | 10.1021/ml500389m | ||
| CHEMBL3358920 | 1596 | None | 39 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay |
ChEMBL | 457 | 6 | 2 | 2 | 6.9 | OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 | 10.1021/ml500389m | ||
| DB14766 | 1596 | None | 39 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human S1P4 receptor by beta-arrestin recruitment assayAgonist activity at human S1P4 receptor by beta-arrestin recruitment assay |
ChEMBL | 457 | 6 | 2 | 2 | 6.9 | OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 | 10.1021/ml500389m | ||
| 134130111 | 142390 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 347 | 5 | 2 | 3 | 4.9 | O=C(O)CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 | 10.1016/j.bmcl.2016.11.050 | ||
| CHEMBL3885275 | 142390 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR4 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 347 | 5 | 2 | 3 | 4.9 | O=C(O)CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 | 10.1016/j.bmcl.2016.11.050 | ||
| 11682677 | 11786 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay |
ChEMBL | 395 | 12 | 4 | 4 | 4.1 | CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | ||
| CHEMBL1181748 | 11786 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay |
ChEMBL | 395 | 12 | 4 | 4 | 4.1 | CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | ||
| CHEMBL190865 | 11786 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay |
ChEMBL | 395 | 12 | 4 | 4 | 4.1 | CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | ||
| 44342339 | 11410 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 344 | 10 | 4 | 4 | 2.2 | CCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | ||
| CHEMBL114031 | 11410 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 344 | 10 | 4 | 4 | 2.2 | CCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | ||
| CHEMBL1180115 | 11410 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 344 | 10 | 4 | 4 | 2.2 | CCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | ||
| 44398076 | 12905 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay |
ChEMBL | 425 | 13 | 5 | 5 | 3.2 | CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | ||
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