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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

CHEMBL1090796	8023	None	0	Human	Binding	IC50	=	13.10	7.88	-	4	Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting	ChEMBL	482.2	10	4	5	3.93	C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(C(=O)CCc2ccc(-c3ccccc3)cc2)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.02.098
CHEMBL1090829	8033	None	0	Human	Binding	IC50	=	6.50	8.19	-	3	Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting	ChEMBL	561.2	10	4	5	5.67	C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCc3ccc(-c4ccccc4)cc3)c(C(F)(F)F)c2)c[nH]1	https://dx.doi.org/10.1016/j.bmcl.2010.02.098
CHEMBL1093429	8413	None	0	Human	Binding	IC50	=	3.40	8.47	-	4	Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting	ChEMBL	538.1	10	4	5	4.76	C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)c(C(F)(F)F)c1	https://dx.doi.org/10.1016/j.bmcl.2010.02.098
CHEMBL1093823	8466	None	0	Human	Binding	IC50	=	4.40	8.36	-	4	Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting	ChEMBL	547.1	9	4	5	5.63	C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)c(C(F)(F)F)c2)c[nH]1	https://dx.doi.org/10.1016/j.bmcl.2010.02.098
CHEMBL1095833	8719	None	24	Human	Binding	IC50	=	1956.00	5.71	-	4	Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting	ChEMBL	460.1	8	2	6	4.27	CCC/N=C1\S/C(=C\c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C	https://dx.doi.org/10.1021/jm100181s
CHEMBL112655	9627	None	0	Human	Binding	IC50	=	140.00	6.85	-	4	Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes	ChEMBL	371.2	13	4	3	3.39	CCCCCCCCc1ccc(CCC(N)C(O)CP(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2004.02.106
CHEMBL113344	9736	None	0	Human	Binding	IC50	=	23.00	7.64	-	4	Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes	ChEMBL	371.2	13	4	3	3.74	CCCCCCCCc1ccc(CCC(N)CC(O)P(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2004.02.106
CHEMBL114584	9939	None	2	Human	Binding	IC50	=	210.00	6.68	-	4	Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes	ChEMBL	385.2	14	4	3	3.78	CCCCCCCCc1ccc(CCC(N)(CO)CCP(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2004.02.106
CHEMBL114976	10016	None	0	Human	Binding	IC50	=	500.00	6.30	-	4	Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes	ChEMBL	371.2	13	4	3	3.74	CCCCCCCCc1ccc(CC[C@H](N)C[C@@H](O)P(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2004.02.106
CHEMBL115554	10108	None	0	Human	Binding	IC50	=	16.00	7.80	-	4	Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes	ChEMBL	371.2	13	4	3	3.74	CCCCCCCCc1ccc(CC[C@@H](N)C[C@@H](O)P(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2004.02.106
CHEMBL115713	10138	None	2	Human	Binding	IC50	=	16.00	7.80	-	4	Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand	ChEMBL	371.2	13	4	3	3.74	CCCCCCCCc1ccc(CC[C@@H](N)C[C@H](O)P(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2004.04.069
CHEMBL115713	10138	None	2	Human	Binding	IC50	=	280.00	6.55	-	4	Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes	ChEMBL	371.2	13	4	3	3.74	CCCCCCCCc1ccc(CC[C@@H](N)C[C@H](O)P(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2004.02.106
CHEMBL115714	10139	None	0	Human	Binding	IC50	=	880.00	6.06	-	4	Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes	ChEMBL	371.2	13	4	3	3.74	CCCCCCCCc1ccc(CC[C@H](N)C[C@H](O)P(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2004.02.106
CHEMBL115738	10144	None	0	Human	Binding	IC50	=	800.00	6.10	-	4	Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand	ChEMBL	363.3	19	3	2	5.63	CCCCCCCCCCCCCCCCNCCCP(=O)(O)O	https://dx.doi.org/10.1016/j.bmcl.2004.04.069
CHEMBL1160958	10248	None	0	Human	Binding	IC50	=	900.00	6.05	-	4	Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand	ChEMBL	339.2	14	3	3	4.76	CCCCCCCCCc1ccc(CNCCCP(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2004.04.069
CHEMBL116140	10273	None	0	Human	Binding	IC50	=	1400.00	5.85	-	4	Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand	ChEMBL	335.2	14	3	3	3.90	CCCCCCCCCc1ccc(CNCC(O)CC(=O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2004.04.069
CHEMBL1161691	10294	None	0	Human	Binding	IC50	=	15.00	7.82	-	5	Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes	ChEMBL	389.2	14	5	6	2.62	CCCCCCCCc1ccc(CCC(N)(CO)CO[PH](O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2004.07.049
CHEMBL117031	10646	None	0	Human	Binding	IC50	=	94.00	7.03	-	4	Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand	ChEMBL	355.2	14	3	2	4.63	NC(CCCCCCCCCCc1ccccc1)CCP(=O)(O)O	https://dx.doi.org/10.1016/j.bmcl.2004.04.069
CHEMBL117130	10754	None	0	Human	Binding	IC50	=	15.00	7.82	-	4	Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand	ChEMBL	373.2	13	4	4	3.28	CCCCCCCCc1ccc(CCC(N)(CO)OP(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2004.04.069
CHEMBL117723	11057	None	0	Human	Binding	IC50	=	80.00	7.10	-	6	Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells	ChEMBL	465.1	15	3	4	4.85	CCCCCCCCOc1c(Br)cc(CNCCCP(=O)(O)O)cc1OC	https://dx.doi.org/10.1021/jm0492507

Showing 1 to 20 of 220 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

(S)-FTY720-phosphate	3596	None	37	Human	Functional	EC50	=	0.60	9.22	-26	6	Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand	ChEMBL	387.2	14	4	4	3.32	CCCCCCCCc1ccc(CC[C@](N)(CO)COP(=O)(O)O)cc1	https://dx.doi.org/10.1021/jm050242f
(S)-FTY720-phosphate	3596	None	37	Human	Functional	EC50	=	1.60	8.80	-26	6	Agonist activity at human recombinant S1P4 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay	ChEMBL	387.2	14	4	4	3.32	CCCCCCCCc1ccc(CC[C@](N)(CO)COP(=O)(O)O)cc1	https://dx.doi.org/10.1021/acs.jmedchem.8b01695
(S)-FTY720-phosphate	3596	None	37	Human	Functional	EC50	=	22.00	7.66	-26	6	Agonist activity at recombinant human S1P4 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assay	ChEMBL	387.2	14	4	4	3.32	CCCCCCCCc1ccc(CC[C@](N)(CO)COP(=O)(O)O)cc1	https://dx.doi.org/10.1021/acsmedchemlett.0c00631
(S)-FTY720-phosphate	3596	None	37	Human	Functional	IC50	=	2.20	8.66	-26	6	Agonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay	ChEMBL	387.2	14	4	4	3.32	CCCCCCCCc1ccc(CC[C@](N)(CO)COP(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.10.088
(S)-FTY720-phosphate	3596	None	37	Human	Functional	EC50	=	199.53	6.70	-26	6	Agonist activity at human S1P4 expressed in CHO-K1 aequorin cells assessed as calcium accumulation of by luminescence assay in presence of cofactor coelenterazine	ChEMBL	387.2	14	4	4	3.32	CCCCCCCCc1ccc(CC[C@](N)(CO)COP(=O)(O)O)cc1	https://dx.doi.org/10.1021/jm200609t
(S)-FTY720-phosphate	3596	None	37	Human	Functional	EC50	=	22.16	7.65	-26	6	Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay	ChEMBL	387.2	14	4	4	3.32	CCCCCCCCc1ccc(CC[C@](N)(CO)COP(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.02.006
9,10-PHENANTHRENEQUINONE	191556	None	60	Human	Functional	IC50	=	2029.00	5.69	1	3	PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)]	ChEMBL	208.1	0	0	2	2.73	O=C1C(=O)c2ccccc2-c2ccccc21	-
AFD(R)	303	None	0	Human	Functional	EC50	=	1.26	8.90	-1	4	Binding potency at human S1P4 receptor by [35S]GTP-gamma-S binding assay	ChEMBL	373.2	13	3	4	3.79	CCCCCCCOc1ccc(CC[C@@](C)(N)COP(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2005.09.038
AFD(R)	303	None	0	Human	Functional	pEC50	=	-	8.35	-1	4	Unclassified	Guide to Pharmacology	373.2	13	3	4	3.79	CCCCCCCOc1ccc(CC[C@@](C)(N)COP(=O)(O)O)cc1	https://pubmed.ncbi.nlm.nih.gov/11967257
AFD(R)	303	None	0	Human	Functional	pEC50	=	-	8.35	-1	4	Unclassified	Guide to Pharmacology	373.2	13	3	4	3.79	CCCCCCCOc1ccc(CC[C@@](C)(N)COP(=O)(O)O)cc1	https://pubmed.ncbi.nlm.nih.gov/14732717
ASP4058	502	None	23	Human	Functional	pEC50	=	-	5.64	-301	4	In a GTPγS binding assay.	Guide to Pharmacology	442.1	4	1	5	5.63	C[C@H](Oc1ccc(-c2nc(-c3ccc4[nH]cnc4c3)no2)cc1C(F)(F)F)C(F)(F)F	https://pubmed.ncbi.nlm.nih.gov/25347187
AUY954	524	None	19	Mouse	Functional	pEC50	None	-	5.50	-3548	7	Unclassified	Guide to Pharmacology	455.1	7	2	3	6.82	O=C(O)CCNCc1ccc2sc(-c3ccc(-c4ccccc4)c(C(F)(F)F)c3)cc2c1	https://pubmed.ncbi.nlm.nih.gov/17114004
CHEMBL1077288	5603	None	0	Human	Functional	EC50	=	800.00	6.10	-3	3	Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding	ChEMBL	335.2	13	2	3	4.55	CCCCCCCOc1ccc(CC[C@](C)(N)CCC(=O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.01.118
CHEMBL1083841	6768	None	0	Human	Functional	EC50	=	1700.00	5.77	-3	4	Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding	ChEMBL	425.2	13	2	5	2.75	CCCCCCCOc1ccc(CC[C@](C)(N)CCN2CC(=O)NS2(=O)=O)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.01.118
CHEMBL1084929	7060	None	0	Human	Functional	EC50	=	5.70	8.24	-6	4	Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding	ChEMBL	373.2	13	3	4	3.79	CCCCCCCOc1ccc(CC[C@](C)(N)COP(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.01.118
CHEMBL1085191	7107	None	0	Human	Functional	EC50	=	670.00	6.17	1	4	Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding	ChEMBL	359.3	13	2	5	3.83	CCCCCCCOc1ccc(CC[C@](C)(N)CCc2nnn[nH]2)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.01.118
CHEMBL1086170	7332	None	0	Human	Functional	EC50	=	19.00	7.72	1	4	Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding	ChEMBL	371.2	13	3	3	4.25	CCCCCCCOc1ccc(CC[C@](C)(N)CCP(=O)(O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.01.118
CHEMBL1086171	7333	None	0	Human	Functional	EC50	=	140.00	6.85	-3	3	Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding	ChEMBL	307.2	11	2	3	3.77	CCCCCCCOc1ccc(CC[C@](C)(N)C(=O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.01.118
CHEMBL1086172	7334	None	0	Human	Functional	EC50	=	120.00	6.92	-6	4	Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding	ChEMBL	321.2	12	2	3	4.16	CCCCCCCOc1ccc(CC[C@](C)(N)CC(=O)O)cc1	https://dx.doi.org/10.1016/j.bmcl.2010.01.118
CHEMBL1091103	8061	None	0	Human	Functional	EC50	=	41.45	7.38	-9	4	Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay	ChEMBL	413.2	12	4	4	3.49	CCCCCCCCc1ccc2c(c1)CC[C@@H](C(N)(CO)COP(=O)(O)O)C2	https://dx.doi.org/10.1016/j.bmcl.2010.02.006

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Ligand source activities (1 row/activity)